                               SEQUENCE LISTING

<110> LIFE TECHNOLOGIES CORPORATION
 
<120> METHODS AND COMPOSITIONS FOR DETECTING OR MEASURING CASPASES OR 
      APOPTOSIS

<130> LT01158PCT

<140>
<141>

<150> 62/353,892
<151> 2016-06-23

<160> 24    

<170> PatentIn version 3.5

<210> 1
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 3/7"

<400> 1
Asp Glu Val Asp 
1               


<210> 2
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 9"

<400> 2
Leu Glu His Asp 
1               


<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 3/7"

<400> 3
Asp Glu Val Asp Gly 
1               5   


<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 3/7"

<400> 4
Gly Asp Glu Val Asp Gly Ile Lys 
1               5               


<210> 5
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="Tyr" or "Ile" or "Leu" or "Asp" or "Val"

<220>
<221> MOD_RES
<222> (3)..(3)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (1)..(4)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 5
Trp Glu Xaa Asp 
1               


<210> 6
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence"


<220>
<221> VARIANT
<222> (1)..(1)
<223> /replace="Leu"

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 6
Val Asp Glu Xaa Asp 
1               5   


<210> 7
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence"


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<400> 7
Asp Xaa Val Asp 
1               


<210> 8
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="Tyr" or "Ile" or "Leu" or "Val"

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 8
Asp Trp Glu Xaa Asp 
1               5   


<210> 9
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 1/5"

<400> 9
Trp Glu His Asp 
1               


<210> 10
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 1"

<400> 10
Tyr Val Ala Asp 
1               


<210> 11
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 1"

<400> 11
Tyr Val His Asp 
1               


<210> 12
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 2"

<400> 12
Val Asp Val Ala Asp 
1               5   


<210> 13
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 8"

<400> 13
Ile Glu Thr Asp 
1               


<210> 14
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 6"

<400> 14
Val Glu Ile Asp 
1               


<210> 15
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 4/9"

<400> 15
Leu Glu Val Asp 
1               


<210> 16
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 10"

<400> 16
Ala Glu Val Asp 
1               


<210> 17
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 8"

<400> 17
Asp Ile Glu Thr Asp 
1               5   


<210> 18
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 9"

<400> 18
Asp Leu Glu His Asp 
1               5   


<210> 19
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence, 
      e.g., for Caspase 1"

<400> 19
Asp Tyr Val Ala Asp 
1               5   


<210> 20
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="Tyr" or "Ile" or "Leu" or "Val"

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 20
Asp Trp Val Xaa Asp 
1               5   


<210> 21
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence"


<220>
<221> MOD_RES
<222> (1)..(100)
<223> Any amino acid or not present

<220>
<221> MOD_RES
<222> (106)..(205)
<223> Any amino acid or not present

<400> 21
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Asp Glu Val Asp Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205 


<210> 22
<211> 104
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      cleaved peptide fragment after treatment with caspase"


<220>
<221> MOD_RES
<222> (1)..(100)
<223> Any amino acid or not present

<400> 22
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Asp Glu Val Asp 
            100                 


<210> 23
<211> 101
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      cleaved peptide fragment after treatment with caspase"


<220>
<221> MOD_RES
<222> (2)..(101)
<223> Any amino acid or not present

<400> 23
Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa 
            100     


<210> 24
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide with caspase recognition/cleavage sequence"


<220>
<221> VARIANT
<222> (2)..(2)
<223> /replace="Tyr" or "Ile" or "Leu" or "Val" or "Asp"

<220>
<221> VARIANT
<222> (3)..(3)
<223> /replace="Val"

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<220>
<221> MISC_FEATURE
<222> (1)..(5)
<223> /note="Variant residues given in the sequence have no 
      preference with respect to those in the annotations
      for variant positions"

<400> 24
Asp Trp Glu Xaa Asp 
1               5   


