                         SEQUENCE LISTING

<110>  Universitt Ulm
 
<120>  Complement Inhibitors and Uses thereof

<130>  UU14017PC

<150>  EP16176739.7
<151>  2016-06-28

<160>  18    

<170>  PatentIn version 3.3

<210>  1
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Gln Leu 
1               5                   10                  15      


Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu Cys 
            20                  25                  30          


Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys Asn 
        35                  40                  45              


Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys Arg 
    50                  55                  60                  


Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly Ile 
65                  70                  75                  80  


Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg Leu 
                85                  90                  95      


Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val Ile 
            100                 105                 110         


Trp Asp Gln Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu Pro 
        115                 120                 125             


Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe 
    130                 135                 140                 


His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly 
145                 150                 155                 160 


Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser 
                165                 170                 175     


Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile 
            180                 185                 190         


Ile 
    


<210>  2
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu Glu 
1               5                   10                  15      


Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys Cys Glu 
            20                  25                  30          


Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile Cys Leu 
        35                  40                  45              


Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Gln Arg Ser Cys 
    50                  55                  60                  


Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr Ile 
65                  70                  75                  80  


Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu Cys Arg 
                85                  90                  95      


Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr Cys Leu 
            100                 105                 110         


Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys Lys Ser 
        115                 120                 125             


Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro Gly 
    130                 135                 140                 


Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly Tyr 
145                 150                 155                 160 


Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser 
                165                 170                 175     


Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro 
            180                 185                 190         


Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp His 
        195                 200                 205             


Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe Thr 
    210                 215                 220                 


Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly 
225                 230                 235                 240 


Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg 
                245                 250 


<210>  3
<211>  194
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr 
1               5                   10                  15      


Gln Thr Gln Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu 
            20                  25                  30          


Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp 
        35                  40                  45              


Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys 
    50                  55                  60                  


Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp 
65                  70                  75                  80  


Ile Gln Val Gly Ser Arg Ile Gln Tyr Ser Cys Thr Thr Gly His Arg 
                85                  90                  95      


Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr Ala 
            100                 105                 110         


His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu 
        115                 120                 125             


Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn 
    130                 135                 140                 


Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu Gly Ser Arg 
145                 150                 155                 160 


Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr 
                165                 170                 175     


Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys 
            180                 185                 190         


Ile Ile 
        


<210>  4
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  4

Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe 
1               5                   10                  15      


Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln 
            20                  25                  30          


Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly 
        35                  40                  45              


Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg 
    50                  55                  60                  


Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln 
65                  70                  75                  80  


Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg 
                85                  90                  95      


Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp 
            100                 105                 110         


Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala 
        115                 120         


<210>  5
<211>  529
<212>  PRT
<213>  Artificial

<220>
<223>  artificial multi-domain polypeptide, CR1-derived first CCP domain

<400>  5

Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Gln Leu 
1               5                   10                  15      


Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu Cys 
            20                  25                  30          


Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys Asn 
        35                  40                  45              


Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys Arg 
    50                  55                  60                  


Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly Ile 
65                  70                  75                  80  


Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg Leu 
                85                  90                  95      


Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val Ile 
            100                 105                 110         


Trp Asp Gln Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu Pro 
        115                 120                 125             


Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe 
    130                 135                 140                 


His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly 
145                 150                 155                 160 


Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser 
                165                 170                 175     


Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile 
            180                 185                 190         


Ile Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Lys 
        195                 200                 205             


Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro 
    210                 215                 220                 


Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
225                 230                 235                 240 


Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
                245                 250                 255     


Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
            260                 265                 270         


Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
        275                 280                 285             


Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
    290                 295                 300                 


Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
305                 310                 315                 320 


Gly Lys Leu Glu Tyr Pro Thr Cys Ala Gly Gly Gly Gly Gly Gly Gly 
                325                 330                 335     


His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln 
            340                 345                 350         


Thr Gln Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys 
        355                 360                 365             


Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn 
    370                 375                 380                 


Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys 
385                 390                 395                 400 


Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp Ile 
                405                 410                 415     


Gln Val Gly Ser Arg Ile Gln Tyr Ser Cys Thr Thr Gly His Arg Leu 
            420                 425                 430         


Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr Ala His 
        435                 440                 445             


Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro 
    450                 455                 460                 


Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe 
465                 470                 475                 480 


His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu Gly Ser Arg Gly 
                485                 490                 495     


Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser 
            500                 505                 510         


Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile 
        515                 520                 525             


Ile 
    


<210>  6
<211>  587
<212>  PRT
<213>  Artificial

<220>
<223>  artificial multi-domain polypeptide, DAF-derived first CCP domain

<400>  6

Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu Glu 
1               5                   10                  15      


Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys Cys Glu 
            20                  25                  30          


Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile Cys Leu 
        35                  40                  45              


Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Gln Arg Ser Cys 
    50                  55                  60                  


Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr Ile 
65                  70                  75                  80  


Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu Cys Arg 
                85                  90                  95      


Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr Cys Leu 
            100                 105                 110         


Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys Lys Ser 
        115                 120                 125             


Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro Gly 
    130                 135                 140                 


Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly Tyr 
145                 150                 155                 160 


Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser 
                165                 170                 175     


Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro 
            180                 185                 190         


Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp His 
        195                 200                 205             


Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe Thr 
    210                 215                 220                 


Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly 
225                 230                 235                 240 


Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Lys Cys Gly Pro Pro Pro Pro 
            260                 265                 270         


Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro 
        275                 280                 285             


Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly 
    290                 295                 300                 


Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys 
305                 310                 315                 320 


Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn 
                325                 330                 335     


Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly 
            340                 345                 350         


Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg 
        355                 360                 365             


Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro 
    370                 375                 380                 


Thr Cys Ala Gly Gly Gly Gly Gly Gly Gly His Cys Gln Ala Pro Asp 
385                 390                 395                 400 


His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Gln Ala Ser Asp Phe 
                405                 410                 415     


Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly 
            420                 425                 430         


Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser Pro 
        435                 440                 445             


Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro Val 
    450                 455                 460                 


Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg Ile 
465                 470                 475                 480 


Gln Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser Ala 
                485                 490                 495     


Glu Cys Ile Leu Ser Gly Asn Thr Ala His Trp Ser Thr Lys Pro Pro 
            500                 505                 510         


Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn Gly 
        515                 520                 525             


Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val 
    530                 535                 540                 


Thr Tyr Arg Cys Asn Leu Gly Ser Arg Gly Arg Lys Val Phe Glu Leu 
545                 550                 555                 560 


Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly 
                565                 570                 575     


Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile 
            580                 585         


<210>  7
<211>  1587
<212>  DNA
<213>  Artificial

<220>
<223>  artificial multi-domain polypeptide encoding sequence, 
       CR1-derived first CCP domain

<400>  7
cagtgcaacg cgccggaatg gctgccgttt gcgcgcccga cccagctgac cgatgaattt     60

gaatttccga ttggcaccta tctgaactat gaatgccgcc cgggctatag cggccgcccg    120

tttagcatta tttgcctgaa aaacagcgtg tggaccggcg cgaaagatcg ctgccgccgc    180

aaaagctgcc gcaacccgcc ggatccggtg aacggcatgg tgcatgtgat taaaggcatt    240

cagtttggca gccagattaa atatagctgc accaaaggct atcgcctgat tggcagcagc    300

agcgcgacct gcattattag cggcgatacc gtgatttggg atcaggaaac cccgatttgc    360

gatcgcattc cgtgcggcct gccgccgacc attaccaacg gcgattttat tagcaccaac    420

cgcgaaaact ttcattatgg cagcgtggtg acctatcgct gcaacccggg cagcggcggc    480

cgcaaagtgt ttgaactggt gggcgaaccg agcatttatt gcaccagcaa cgatgatcag    540

gtgggcattt ggagcggccc ggcgccgcag tgcattattg gcggcggcgg cggcggcggc    600

ggcggcggcg gcggcggcgg caaatgcggc ccgccgccgc cgattgataa cggcgatatt    660

accagctttc cgctgagcgt gtatgcgccg gcgagcagcg tggaatatca gtgccagaac    720

ctgtatcagc tggaaggcaa caaacgcatt acctgccgca acggccagtg gagcgaaccg    780

ccgaaatgcc tgcatccgtg cgtgattagc cgcgaaatta tggaaaacta taacattgcg    840

ctgcgctgga ccgcgaaaca gaaactgtat agccgcaccg gcgaaagcgt ggaatttgtg    900

tgcaaacgcg gctatcgcct gagcagccgc agccataccc tgcgcaccac ctgctgggat    960

ggcaaactgg aatatccgac ctgcgcgggc ggcggcggcg gcggcggcca ttgccaggcg   1020

ccggatcatt ttctgtttgc gaaactgaaa acccagaccc aggcgagcga ttttccgatt   1080

ggcaccagcc tgaaatatga atgccgcccg gaatattatg gccgcccgtt tagcattacc   1140

tgcctggata acctggtgtg gagcagcccg aaagatgtgt gcaaacgcaa aagctgcaaa   1200

accccgccgg atccggtgaa cggcatggtg catgtgatta ccgatattca ggtgggcagc   1260

cgcattcagt atagctgcac caccggccat cgcctgattg gccatagcag cgcggaatgc   1320

attctgagcg gcaacaccgc gcattggagc accaaaccgc cgatttgcca gcgcattccg   1380

tgcggcctgc cgccgaccat tgcgaacggc gattttatta gcaccaaccg cgaaaacttt   1440

cattatggca gcgtggtgac ctatcgctgc aacctgggca gccgcggccg caaagtgttt   1500

gaactggtgg gcgaaccgag catttattgc accagcaacg atgatcaggt gggcatttgg   1560

agcggcccgg cgccgcagtg cattatt                                       1587


<210>  8
<211>  1761
<212>  DNA
<213>  Artificial

<220>
<223>  artificial multi-domain polypeptide encoding sequence, 
       DAF-derived first CCP domain

<400>  8
gattgcggcc tgccgccgga tgtgccgaac gcgcagccgg cgctggaagg ccgcaccagc     60

tttccggaag ataccgtgat tacctataaa tgcgaagaaa gctttgtgaa aattccgggc    120

gaaaaagata gcgtgatttg cctgaaaggc agccagtgga gcgatattga agaattttgc    180

cagcgcagct gcgaagtgcc gacccgcctg aacagcgcga gcctgaaaca gccgtatatt    240

acccagaact attttccggt gggcaccgtg gtggaatatg aatgccgccc gggctatcgc    300

cgcgaaccga gcctgagccc gaaactgacc tgcctgcaga acctgaaatg gagcaccgcg    360

gtggaatttt gcaaaaaaaa aagctgcccg aacccgggcg aaattcgcaa cggccagatt    420

gatgtgccgg gcggcattct gtttggcgcg accattagct ttagctgcaa caccggctat    480

aaactgtttg gcagcaccag cagcttttgc ctgattagcg gcagcagcgt gcagtggagc    540

gatccgctgc cggaatgccg cgaaatttat tgcccggcgc cgccgcagat tgataacggc    600

attattcagg gcgaacgcga tcattatggc tatcgccaga gcgtgaccta tgcgtgcaac    660

aaaggcttta ccatgattgg cgaacatagc atttattgca ccgtgaacaa cgatgaaggc    720

gaatggagcg gcccgccgcc ggaatgccgc ggcggcggcg gcggcggcgg cggcggcggc    780

ggcggcggcg gcggcaaatg cggcccgccg ccgccgattg ataacggcga tattaccagc    840

tttccgctga gcgtgtatgc gccggcgagc agcgtggaat atcagtgcca gaacctgtat    900

cagctggaag gcaacaaacg cattacctgc cgcaacggcc agtggagcga accgccgaaa    960

tgcctgcatc cgtgcgtgat tagccgcgaa attatggaaa actataacat tgcgctgcgc   1020

tggaccgcga aacagaaact gtatagccgc accggcgaaa gcgtggaatt tgtgtgcaaa   1080

cgcggctatc gcctgagcag ccgcagccat accctgcgca ccacctgctg ggatggcaaa   1140

ctggaatatc cgacctgcgc gggcggcggc ggcggcggcg gccattgcca ggcgccggat   1200

cattttctgt ttgcgaaact gaaaacccag acccaggcga gcgattttcc gattggcacc   1260

agcctgaaat atgaatgccg cccggaatat tatggccgcc cgtttagcat tacctgcctg   1320

gataacctgg tgtggagcag cccgaaagat gtgtgcaaac gcaaaagctg caaaaccccg   1380

ccggatccgg tgaacggcat ggtgcatgtg attaccgata ttcaggtggg cagccgcatt   1440

cagtatagct gcaccaccgg ccatcgcctg attggccata gcagcgcgga atgcattctg   1500

agcggcaaca ccgcgcattg gagcaccaaa ccgccgattt gccagcgcat tccgtgcggc   1560

ctgccgccga ccattgcgaa cggcgatttt attagcacca accgcgaaaa ctttcattat   1620

ggcagcgtgg tgacctatcg ctgcaacctg ggcagccgcg gccgcaaagt gtttgaactg   1680

gtgggcgaac cgagcattta ttgcaccagc aacgatgatc aggtgggcat ttggagcggc   1740

ccggcgccgc agtgcattat t                                             1761


<210>  9
<211>  329
<212>  PRT
<213>  Artificial

<220>
<223>  CR1(1-3)FH(19-20) long linker polypeptide

<400>  9

Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Gln Leu 
1               5                   10                  15      


Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu Cys 
            20                  25                  30          


Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys Asn 
        35                  40                  45              


Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys Arg 
    50                  55                  60                  


Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly Ile 
65                  70                  75                  80  


Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg Leu 
                85                  90                  95      


Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val Ile 
            100                 105                 110         


Trp Asp Gln Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu Pro 
        115                 120                 125             


Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe 
    130                 135                 140                 


His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly 
145                 150                 155                 160 


Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser 
                165                 170                 175     


Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile 
            180                 185                 190         


Ile Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Lys 
        195                 200                 205             


Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro 
    210                 215                 220                 


Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
225                 230                 235                 240 


Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
                245                 250                 255     


Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
            260                 265                 270         


Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
        275                 280                 285             


Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
    290                 295                 300                 


Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
305                 310                 315                 320 


Gly Lys Leu Glu Tyr Pro Thr Cys Ala 
                325                 


<210>  10
<211>  321
<212>  PRT
<213>  Artificial

<220>
<223>  CR1(1-3)FH(19-20)short linker polypeptide

<400>  10

Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Gln Leu 
1               5                   10                  15      


Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu Cys 
            20                  25                  30          


Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys Asn 
        35                  40                  45              


Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys Arg 
    50                  55                  60                  


Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly Ile 
65                  70                  75                  80  


Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg Leu 
                85                  90                  95      


Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val Ile 
            100                 105                 110         


Trp Asp Gln Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu Pro 
        115                 120                 125             


Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe 
    130                 135                 140                 


His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly 
145                 150                 155                 160 


Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser 
                165                 170                 175     


Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile 
            180                 185                 190         


Ile Gly Pro Gly Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly 
        195                 200                 205             


Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val 
    210                 215                 220                 


Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile 
225                 230                 235                 240 


Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro 
                245                 250                 255     


Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg 
            260                 265                 270         


Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu 
        275                 280                 285             


Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu 
    290                 295                 300                 


Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys 
305                 310                 315                 320 


Arg 
    


<210>  11
<211>  387
<212>  PRT
<213>  Artificial

<220>
<223>  DAF(1-4)FH(19-20) long linker polypeptide

<400>  11

Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu Glu 
1               5                   10                  15      


Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys Cys Glu 
            20                  25                  30          


Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile Cys Leu 
        35                  40                  45              


Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Gln Arg Ser Cys 
    50                  55                  60                  


Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr Ile 
65                  70                  75                  80  


Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu Cys Arg 
                85                  90                  95      


Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr Cys Leu 
            100                 105                 110         


Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys Lys Ser 
        115                 120                 125             


Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro Gly 
    130                 135                 140                 


Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly Tyr 
145                 150                 155                 160 


Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser 
                165                 170                 175     


Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro 
            180                 185                 190         


Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp His 
        195                 200                 205             


Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe Thr 
    210                 215                 220                 


Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly 
225                 230                 235                 240 


Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Lys Cys Gly Pro Pro Pro Pro 
            260                 265                 270         


Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro 
        275                 280                 285             


Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly 
    290                 295                 300                 


Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys 
305                 310                 315                 320 


Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn 
                325                 330                 335     


Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly 
            340                 345                 350         


Glu Ser Val Glu Phe Val Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg 
        355                 360                 365             


Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro 
    370                 375                 380                 


Thr Cys Ala 
385         


<210>  12
<211>  379
<212>  PRT
<213>  Artificial

<220>
<223>  DAF(1-4)FH(19-20) short linker polypeptide

<400>  12

Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu Glu 
1               5                   10                  15      


Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys Cys Glu 
            20                  25                  30          


Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile Cys Leu 
        35                  40                  45              


Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg Ser Cys 
    50                  55                  60                  


Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr Ile 
65                  70                  75                  80  


Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu Cys Arg 
                85                  90                  95      


Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr Cys Leu 
            100                 105                 110         


Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys Lys Ser 
        115                 120                 125             


Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro Gly 
    130                 135                 140                 


Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly Tyr 
145                 150                 155                 160 


Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser 
                165                 170                 175     


Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro 
            180                 185                 190         


Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp His 
        195                 200                 205             


Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe Thr 
    210                 215                 220                 


Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly 
225                 230                 235                 240 


Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Pro Gly Gly Gly Lys 
                245                 250                 255     


Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro 
            260                 265                 270         


Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn 
        275                 280                 285             


Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln 
    290                 295                 300                 


Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu 
305                 310                 315                 320 


Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 
                325                 330                 335     


Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg Gly 
            340                 345                 350         


Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp 
        355                 360                 365             


Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
    370                 375                 


<210>  13
<211>  1781
<212>  DNA
<213>  Artificial

<220>
<223>  DAF 1-4_FH19-20_CR1_15-17 encoding Pichia optimized

<400>  13
ctgcaggaga ttgcggttta ccaccagatg ttccaaacgc tcaaccagct ttggagggta     60

gaacttcatt cccagaggac accgttatca cctacaagtg tgaagagtcc ttcgtcaaga    120

tcccaggtga aaaggactcc gtcatctgtt tgaagggttc tcagtggtcc gacatcgaag    180

agttctgtca aagatcctgt gaggtcccaa ccagattgaa ctctgcttcc ttgaagcagc    240

cttacatcac ccagaactac ttcccagttg gtactgttgt tgagtacgag tgcagaccag    300

gttacagaag agaaccatct ttgtccccaa agctgacctg cttgcaaaac ttgaagtggt    360

ccactgccgt tgagttctgc aagaagaagt cttgtccaaa cccaggtgag atcagaaacg    420

gtcagattga tgttccaggt ggtatcttgt tcggtgctac tatctccttc tcctgcaaca    480

ccggttacaa gttgttcggt tctacctcct ccttctgctt gatttctggt tcctctgttc    540

aatggtccga cccattgcca gaatgcagag aaatctactg tccagctcca ccacagatcg    600

acaacggtat tattcagggt gagagagatc actacggtta cagacagtcc gttacctacg    660

cttgcaacaa gggtttcact atgattggtg agcactccat ctactgcacc gttaacaacg    720

atgaaggtga atggtctggt ccaccaccag aatgtagagg tggtggagga ggaggcggtg    780

gaggtggagg tggtggtgga ggaaaatgtg gaccaccacc accaattgac aacggtgaca    840

ttacttcctt cccattgtcc gtttacgctc cagcttcttc cgttgagtac cagtgtcaaa    900

acctgtacca gttggagggt aacaagagaa tcacctgtag aaacggtcaa tggtctgagc    960

caccaaagtg cttgcaccca tgtgttatct ccagagaaat catggaaaac tacaacattg   1020

ccctgagatg gaccgccaag caaaagttgt actccagaac tggtgagtcc gttgagttcg   1080

tctgtaagag aggttacaga ctgtcctcca gatcccacac tttgagaact acttgttggg   1140

acggaaagtt ggagtaccct acttgtgccg gaggtggagg aggaggagga cattgtcaag   1200

ctccagatca cttcttgttc gccaagctta agactcagac tcaggcttcc gatttcccaa   1260

tcggtacttc cttgaagtac gaatgtagac cagagtacta cggtagaccc ttctccatca   1320

cttgcttgga caacttggtt tggtcctctc caaaggacgt ctgcaagaga aagtcctgta   1380

agactccacc agacccagtt aacggtatgg ttcacgttat caccgacatc caggttggtt   1440

ccagaatcca gtactcctgt actaccggtc acagattgat tggtcactct tccgctgagt   1500

gtatcttgtc cggtaacact gctcactggt ctactaagcc accaatctgt cagagaatcc   1560

catgtggttt gccaccaact attgctaacg gtgacttcat ctccaccaac agagagaact   1620

tccactacgg ttccgttgtc acctacagat gtaacttggg ttccagaggt agaaaggtgt   1680

tcgagttggt tggtgaacca tccatctact gtacttccaa cgacgaccag gttggtattt   1740

ggtctggtcc tgctccacag tgcatcatct aatagtctag a                       1781


<210>  14
<211>  1607
<212>  DNA
<213>  Artificial

<220>
<223>  CR1-1-3_FH19-20_CR1-15-17 encoding Pichia optimized

<400>  14
ctgcaggaca atgtaacgct ccagaatggt tgccattcgc tagaccaact caattgactg     60

acgagttcga gttcccaatc ggaacatact tgaactacga gtgcagacca ggttactccg    120

gtagaccatt ctccatcatc tgcttgaaga actccgtttg gactggtgcc aaggacagat    180

gtagaagaaa gtcctgtaga aacccaccag acccagttaa cggtatggtt cacgttatca    240

agggtatcca gttcggttcc cagatcaagt actcctgtac caagggttac agactgattg    300

gttcttcctc cgccacttgt attatctccg gtgacactgt tatctgggac caagagactc    360

caatctgcga cagaattcca tgtggtttgc caccaactat caccaacggt gacttcatct    420

ccaccaacag agagaacttc cactacggtt ccgttgtcac ctacagatgt aacccaggtt    480

ctggtggtag aaaggttttc gagttggttg gtgagccatc catctactgt acttccaacg    540

atgaccaggt tggtatttgg tctggtccag ctccacagtg tattattggt ggtggaggag    600

gtggtggagg tggaggcggt ggtggtggaa aatgtggtcc acctcctcct attgacaacg    660

gtgacattac ttccttccca ttgtccgttt acgctccagc ttcttccgtt gagtaccagt    720

gtcaaaacct gtaccagttg gagggtaaca agagaatcac ctgtagaaac ggtcaatggt    780

ccgaaccacc aaagtgcttg cacccatgtg ttatctccag agaaatcatg gaaaactaca    840

acattgccct gagatggacc gccaagcaaa agttgtactc cagaactggt gagtccgttg    900

agttcgtctg taagagaggt tacagattgt cctccagatc ccacactttg agaactactt    960

gttgggacgg aaagttggag taccctactt gtgccggagg tggaggagga ggaggacatt   1020

gtcaagctcc agatcacttc ttgttcgcca agcttaagac tcagactcag gcttccgatt   1080

tccctattgg tacttccctg aagtacgaat gtagacctga gtactatggt agacccttct   1140

ctatcacctg tctggacaac ttggtttggt cctctccaaa ggacgtctgc aagagaaagt   1200

cttgtaagac tccacctgac cccgtcaatg gaatggtcca tgttattacc gacatccagg   1260

tcggatccag aattcagtac tcttgtacta ccggtcacag actgatcggt cactcttctg   1320

ctgagtgtat cttgtccggt aacactgctc actggtctac taagccacca atctgtcaga   1380

gaatcccttg tggattgcca cctaccattg ctaacggtga tttcattagt accaacaggg   1440

aaaattttca ttacggatct gtcgtgacct acagatgcaa cttgggttcc agaggtagaa   1500

aagtctttga actggtcgga gaaccttcca tctactgcac atctaacgac gatcaagtcg   1560

gaatctggtc tggacctgca cctcaatgta tcatctagta atctaga                 1607


<210>  15
<211>  1465
<212>  DNA
<213>  Artificial

<220>
<223>  DAF 1-4_FH19-20_short-linker encoding Pichia optimized

<400>  15
aagatgaaac ggcacaaatt ccggctgaag ctgtcatcgg ttactcagat ttagaagggg     60

atttcgatgt tgctgttttg ccattttcca acagcacaaa taacgggtta ttgtttataa    120

atactactat tgccagcatt gctgctaaag aagaaggggt atctctcgag aaaagagagg    180

ctgaagctgc aggtgattgt ggtttgccac cagatgttcc aaacgctcaa ccagctttgg    240

agggtagaac ttcattccca gaggacactg ttatcactta caagtgtgaa gagtccttcg    300

ttaagatccc aggtgagaag gactccgtta tctgtttgaa gggttctcag tggtccgaca    360

tcgaagagtt ctgtaacaga tcctgtgagg ttccaactag attgaactcc gcttccttga    420

agcagcctta catcactcag aactacttcc cagttggtac tgttgttgag tacgagtgta    480

gaccaggtta cagaagagaa ccatccttgt ccccaaagtt gacttgtttg cagaacttga    540

agtggtccac tgctgttgag ttctgtaaga agaagtcctg tccaaaccca ggtgagatca    600

gaaacggtca gattgatgtt ccaggtggta tcttgttcgg tgctactatc tccttctcct    660

gtaacactgg ttacaagttg ttcggttcca cttcctcatt ctgtttgatc tccggttcct    720

ccgttcaatg gtctgatcca ttgccagagt gtagagagat ctactgtcca gctccaccac    780

agattgacaa cggtattatt cagggtgaga gagatcacta cggttacaga cagtccgtta    840

cttacgcttg taacaagggt ttcactatga tcggtgagca ctccatctac tgtactgtta    900

acaacgacga aggtgagtgg tctggtccac caccagaatg tagaggtccc gggggtggta    960

aatgtggtcc cccaccacca attgacaacg gtgacattac ttccttccca ttgtccgttt   1020

acgctccagc ttcttccgtt gagtaccagt gtcagaactt gtaccagttg gagggtaaca   1080

agagaatcac ttgtagaaac ggtcagtggt ccgagccacc aaaatgtctg cacccatgtg   1140

ttatctccag agaaatcatg gaaaactaca acattgcttt gagatggact gctaagcaga   1200

agttgtactc cagaactggt gagtccgttg agttcgtctg taagagaggt tacagattgt   1260

cctccagatc ccacactttg agaactactt gttgggacgg aaagcttgag tacccaactt   1320

gtgctaagag ataataatct agaacaaaaa ctcatctcag aagaggatct gaatagcgcc   1380

gtcgaccatc atcatcatca tcattgagtt tgtagcctta gacatgactg ttcctcagtt   1440

caagttgggc actacgagaa gcccg                                         1465


<210>  16
<211>  1193
<212>  DNA
<213>  Artificial

<220>
<223>  DAF_FH19-20_long-linker  encoding Pichia optimized

<400>  16
attatactgc aggagattgc ggtttaccac cagatgttcc aaacgctcaa ccagctttgg     60

agggtagaac ttcattccca gaggacaccg ttatcaccta caagtgtgaa gagtccttcg    120

tcaagatccc aggtgaaaag gactccgtca tctgtttgaa gggttctcag tggtccgaca    180

tcgaagagtt ctgtcaaaga tcctgtgagg tcccaaccag attgaactct gcttccttga    240

agcagcctta catcacccag aactacttcc cagttggtac tgttgttgag tacgagtgca    300

gaccaggtta cagaagagaa ccatctttgt ccccaaagct gacctgcttg caaaacttga    360

agtggtccac tgccgttgag ttctgcaaga agaagtcttg tccaaaccca ggtgagatca    420

gaaacggtca gattgatgtt ccaggtggta tcttgttcgg tgctactatc tccttctcct    480

gcaacaccgg ttacaagttg ttcggttcta cctcctcctt ctgcttgatt tctggttcct    540

ctgttcaatg gtccgaccca ttgccagaat gcagagaaat ctactgtcca gctccaccac    600

agatcgacaa cggtattatt cagggtgaga gagatcacta cggttacaga cagtccgtta    660

cctacgcttg caacaagggt ttcactatga ttggtgagca ctccatctac tgcaccgtta    720

acaacgatga aggtgaatgg tctggtccac caccagaatg tagaggtggt ggaggaggag    780

gcggtggagg tggaggtggt ggtggaggaa aatgtggacc accaccacca attgacaacg    840

gtgacattac ttccttccca ttgtccgttt acgctccagc ttcttccgtt gagtaccagt    900

gtcaaaacct gtaccagttg gagggtaaca agagaatcac ctgtagaaac ggtcaatggt    960

ctgagccacc aaagtgcttg cacccatgtg ttatctccag agaaatcatg gaaaactaca   1020

acattgccct gagatggacc gccaagcaaa agttgtactc cagaactggt gagtccgttg   1080

agttcgtctg taagagaggt tacagactgt cctccagatc ccacactttg agaactactt   1140

gttgggacgg aaagttggag taccctactt gtgcctaata gtctagaata tta          1193


<210>  17
<211>  1404
<212>  DNA
<213>  Artificial

<220>
<223>  CR1-1-3_FH19-20_short-linker encoding Pichia optimized

<400>  17
gagagatcaa aaaacaacta attattcgaa acgatgagat ttccttcaat ttttactgct     60

gttttattcg cagcatcctc cgcattagct gctccagtca acactacaac agaagatgaa    120

acggcacaaa ttccggctga agctgtcatc ggttactcag atttagaagg ggatttcgat    180

gttgctgttt tgccattttc caacagcaca aataacgggt tattgtttat aaatactact    240

attgccagca ttgctgctaa agaagaaggg gtatctctcg agaaaagaga ggctgaagct    300

gcaggacaat gtaacgctcc agagtggttg ccatttgcta gaccaactca gttgactgac    360

gagttcgagt tcccaatcgg tacttacttg aactacgagt gcagacctgg ttattctggt    420

agaccattct ccatcatctg cctgaagaac tctgtttgga ctggtgctaa ggacagatgc    480

agaagaaagt cctgtagaaa cccaccagat ccagttaacg gaatggtcca cgtcattaag    540

ggtattcagt tcggttccca gatcaagtac tcctgtacca agggttacag attgattggt    600

tcctcctccg ctacttgtat tatctccggt gacaccgtta tttgggacca agagactcca    660

atctgcgaca gaattccatg tggattgcca ccaactattg ccaacggtga cttcatctcc    720

actaacagag agaacttcca ctacggttcc gttgttacct acagatgtaa cccaggttct    780

ggtggtagaa aggttttcga gctggttggt gaaccatcca tctactgtac ttccaacgac    840

gaccaagttg gtatttggag tggtccagct ccacaatgca tcatccccgg gggtggtaaa    900

tgtggtcccc caccaccaat tgacaacggt gacattactt ccttcccatt gtccgtttac    960

gctccagctt cttccgttga gtaccagtgt cagaacttgt accagttgga gggtaacaag   1020

agaatcactt gtagaaacgg tcagtggtcc gagccaccaa aatgtctgca cccatgtgtt   1080

atctccagag aaatcatgga aaactacaac attgctttga gatggactgc taagcagaag   1140

ttgtactcca gaactggtga gtccgttgag ttcgtctgta agagaggtta cagattgtcc   1200

tccagatccc acactttgag aactacttgt tgggacggaa agcttgagta cccaacttgt   1260

gctaagagat aataatctag aacaaaaact catctcagaa gaggatctga atagcgccgt   1320

cgaccatcat catcatcatc attgagtttg tagccttaga catgactgtt cctcagttca   1380

agttgggcac ttacgagaag accg                                          1404


<210>  18
<211>  1019
<212>  DNA
<213>  Artificial

<220>
<223>  CR1-1-3_FH19-20_long-linker encoding Pichia optimized

<400>  18
atattactgc aggacaatgt aacgctccag aatggttgcc attcgctaga ccaactcaat     60

tgactgacga gttcgagttc ccaatcggaa catacttgaa ctacgagtgc agaccaggtt    120

actccggtag accattctcc atcatctgct tgaagaactc cgtttggact ggtgccaagg    180

acagatgtag aagaaagtcc tgtagaaacc caccagaccc agttaacggt atggttcacg    240

ttatcaaggg tatccagttc ggttcccaga tcaagtactc ctgtaccaag ggttacagac    300

tgattggttc ttcctccgcc acttgtatta tctccggtga cactgttatc tgggaccaag    360

agactccaat ctgcgacaga attccatgtg gtttgccacc aactatcacc aacggtgact    420

tcatctccac caacagagag aacttccact acggttccgt tgtcacctac agatgtaacc    480

caggttctgg tggtagaaag gttttcgagt tggttggtga gccatccatc tactgtactt    540

ccaacgatga ccaggttggt atttggtctg gtccagctcc acagtgtatt attggtggtg    600

gaggaggtgg tggaggtgga ggcggtggtg gtggaaaatg tggtccacct cctcctattg    660

acaacggtga cattacttcc ttcccattgt ccgtttacgc tccagcttct tccgttgagt    720

accagtgtca aaacctgtac cagttggagg gtaacaagag aatcacctgt agaaacggtc    780

aatggtccga accaccaaag tgcttgcacc catgtgttat ctccagagaa atcatggaaa    840

actacaacat tgccctgaga tggaccgcca agcaaaagtt gtactccaga actggtgagt    900

ccgttgagtt cgtctgtaag agaggttaca gattgtcctc cagatcccac actttgagaa    960

ctacttgttg ggacggaaag ttggagtacc ctacttgtgc ctaatagtct agaatatta    1019


