                         SEQUENCE LISTING

<110>  Jablons, David M
       Bhairavi, Tolani
       He, Biao
       Giroux-Leprieur, Etienne
 
<120>  ANTIBODIES SPECIFIC TO SONIC HEDGEHOG AND METHODS OF USE THEREOF

<130>  UCSF-542WO

<150>  62/356,276
<151>  2016-06-29

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  462
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  1

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Gly Pro Gly Arg Gly Phe Gly Lys 
            20                  25                  30          


Arg Arg His Pro Lys Lys Leu Thr Pro Leu Ala Tyr Lys Gln Phe Ile 
        35                  40                  45              


Pro Asn Val Ala Glu Lys Thr Leu Gly Ala Ser Gly Arg Tyr Glu Gly 
    50                  55                  60                  


Lys Ile Ser Arg Asn Ser Glu Arg Phe Lys Glu Leu Thr Pro Asn Tyr 
65                  70                  75                  80  


Asn Pro Asp Ile Ile Phe Lys Asp Glu Glu Asn Thr Gly Ala Asp Arg 
                85                  90                  95      


Leu Met Thr Gln Arg Cys Lys Asp Lys Leu Asn Ala Leu Ala Ile Ser 
            100                 105                 110         


Val Met Asn Gln Trp Pro Gly Val Lys Leu Arg Val Thr Glu Gly Trp 
        115                 120                 125             


Asp Glu Asp Gly His His Ser Glu Glu Ser Leu His Tyr Glu Gly Arg 
    130                 135                 140                 


Ala Val Asp Ile Thr Thr Ser Asp Arg Asp Arg Ser Lys Tyr Gly Met 
145                 150                 155                 160 


Leu Ala Arg Leu Ala Val Glu Ala Gly Phe Asp Trp Val Tyr Tyr Glu 
                165                 170                 175     


Ser Lys Ala His Ile His Cys Ser Val Lys Ala Glu Asn Ser Val Ala 
            180                 185                 190         


Ala Lys Ser Gly Gly Cys Phe Pro Gly Ser Ala Thr Val His Leu Glu 
        195                 200                 205             


Gln Gly Gly Thr Lys Leu Val Lys Asp Leu Ser Pro Gly Asp Arg Val 
    210                 215                 220                 


Leu Ala Ala Asp Asp Gln Gly Arg Leu Leu Tyr Ser Asp Phe Leu Thr 
225                 230                 235                 240 


Phe Leu Asp Arg Asp Asp Gly Ala Lys Lys Val Phe Tyr Val Ile Glu 
                245                 250                 255     


Thr Arg Glu Pro Arg Glu Arg Leu Leu Leu Thr Ala Ala His Leu Leu 
            260                 265                 270         


Phe Val Ala Pro His Asn Asp Ser Ala Thr Gly Glu Pro Glu Ala Ser 
        275                 280                 285             


Ser Gly Ser Gly Pro Pro Ser Gly Gly Ala Leu Gly Pro Arg Ala Leu 
    290                 295                 300                 


Phe Ala Ser Arg Val Arg Pro Gly Gln Arg Val Tyr Val Val Ala Glu 
305                 310                 315                 320 


Arg Asp Gly Asp Arg Arg Leu Leu Pro Ala Ala Val His Ser Val Thr 
                325                 330                 335     


Leu Ser Glu Glu Ala Ala Gly Ala Tyr Ala Pro Leu Thr Ala Gln Gly 
            340                 345                 350         


Thr Ile Leu Ile Asn Arg Val Leu Ala Ser Cys Tyr Ala Val Ile Glu 
        355                 360                 365             


Glu His Ser Trp Ala His Arg Ala Phe Ala Pro Phe Arg Leu Ala His 
    370                 375                 380                 


Ala Leu Leu Ala Ala Leu Ala Pro Ala Arg Thr Asp Arg Gly Gly Asp 
385                 390                 395                 400 


Ser Gly Gly Gly Asp Arg Gly Gly Gly Gly Gly Arg Val Ala Leu Thr 
                405                 410                 415     


Ala Pro Gly Ala Ala Asp Ala Pro Gly Ala Gly Ala Thr Ala Gly Ile 
            420                 425                 430         


His Trp Tyr Ser Gln Leu Leu Tyr Gln Ile Gly Thr Trp Leu Leu Asp 
        435                 440                 445             


Ser Glu Ala Leu His Pro Leu Gly Met Ala Val Lys Ser Ser 
    450                 455                 460         


<210>  2
<211>  1383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  2

Ala Thr Gly Ala Ala Cys Thr Thr Cys Gly Gly Gly Cys Thr Cys Ala 
1               5                   10                  15      


Gly Cys Thr Thr Gly Ala Thr Thr Thr Thr Cys Cys Thr Thr Gly Thr 
            20                  25                  30          


Cys Cys Thr Thr Gly Thr Thr Thr Thr Ala Ala Ala Ala Gly Gly Thr 
        35                  40                  45              


Gly Thr Cys Cys Ala Gly Thr Gly Thr Gly Ala Ala Gly Thr Gly Ala 
    50                  55                  60                  


Ala Gly Cys Thr Gly Gly Thr Gly Gly Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Ala Gly Gly Cys Thr Thr Ala Gly Thr Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Ala Gly Gly Gly Thr Cys Cys Cys Thr Gly Ala 
            100                 105                 110         


Ala Ala Cys Thr Cys Thr Cys Cys Thr Gly Thr Gly Cys Ala Gly Cys 
        115                 120                 125             


Cys Thr Cys Thr Gly Gly Ala Thr Thr Cys Ala Cys Thr Thr Thr Cys 
    130                 135                 140                 


Ala Gly Thr Ala Gly Cys Thr Ala Thr Ala Cys Cys Ala Thr Gly Thr 
145                 150                 155                 160 


Cys Thr Thr Gly Gly Gly Thr Thr Cys Gly Cys Cys Ala Gly Ala Cys 
                165                 170                 175     


Thr Cys Cys Gly Gly Cys Gly Ala Ala Gly Ala Gly Gly Cys Thr Gly 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Gly Thr Cys Gly Cys Ala Ala Cys Cys Ala 
        195                 200                 205             


Thr Thr Ala Gly Thr Ala Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly 
    210                 215                 220                 


Thr Ala Ala Cys Ala Cys Cys Thr Ala Cys Thr Ala Thr Cys Cys Ala 
225                 230                 235                 240 


Gly Ala Cys Ala Gly Thr Gly Thr Gly Ala Ala Gly Gly Gly Cys Cys 
                245                 250                 255     


Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys Cys Ala Gly 
            260                 265                 270         


Ala Gly Ala Cys Ala Ala Thr Gly Cys Cys Ala Gly Gly Ala Ala Cys 
        275                 280                 285             


Ala Cys Cys Cys Thr Gly Thr Ala Cys Cys Thr Gly Cys Ala Ala Ala 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Thr Cys Thr Gly Ala Gly Gly Thr Cys 
305                 310                 315                 320 


Thr Gly Ala Gly Gly Ala Cys Ala Cys Gly Gly Cys Cys Ala Thr Gly 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Ala Ala Gly Ala Gly 
            340                 345                 350         


Ala Cys Thr Ala Thr Ala Gly Gly Thr Cys Cys Cys Thr Gly Thr Thr 
        355                 360                 365             


Thr Gly Cys Thr Thr Ala Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala 
    370                 375                 380                 


Gly Gly Gly Ala Cys Thr Cys Thr Gly Gly Thr Cys Ala Cys Thr Gly 
385                 390                 395                 400 


Thr Cys Thr Cys Thr Gly Cys Ala Gly Cys Cys Ala Ala Ala Ala Cys 
                405                 410                 415     


Gly Ala Cys Ala Cys Cys Cys Cys Cys Ala Thr Cys Thr Gly Thr Cys 
            420                 425                 430         


Thr Ala Thr Cys Cys Ala Cys Thr Gly Gly Cys Cys Cys Cys Thr Gly 
        435                 440                 445             


Gly Ala Thr Cys Thr Gly Cys Thr Gly Cys Cys Cys Ala Ala Ala Cys 
    450                 455                 460                 


Thr Ala Ala Cys Thr Cys Cys Ala Thr Gly Gly Thr Gly Ala Cys Cys 
465                 470                 475                 480 


Cys Thr Gly Gly Gly Ala Thr Gly Cys Cys Thr Gly Gly Thr Cys Ala 
                485                 490                 495     


Ala Gly Gly Gly Cys Thr Ala Thr Thr Thr Cys Cys Cys Thr Gly Ala 
            500                 505                 510         


Gly Cys Cys Ala Gly Thr Gly Ala Cys Ala Gly Thr Gly Ala Cys Cys 
        515                 520                 525             


Thr Gly Gly Ala Ala Cys Thr Cys Thr Gly Gly Ala Thr Cys Cys Cys 
    530                 535                 540                 


Thr Gly Thr Cys Cys Ala Gly Cys Gly Gly Thr Gly Thr Gly Cys Ala 
545                 550                 555                 560 


Cys Ala Cys Cys Thr Thr Cys Cys Cys Ala Gly Cys Thr Gly Thr Cys 
                565                 570                 575     


Cys Thr Gly Cys Ala Gly Thr Cys Thr Gly Ala Cys Cys Thr Cys Thr 
            580                 585                 590         


Ala Cys Ala Cys Thr Cys Thr Gly Ala Gly Cys Ala Gly Cys Thr Cys 
        595                 600                 605             


Ala Gly Thr Gly Ala Cys Thr Gly Thr Cys Cys Cys Cys Thr Cys Cys 
    610                 615                 620                 


Ala Gly Cys Ala Cys Cys Thr Gly Gly Cys Cys Cys Ala Gly Cys Gly 
625                 630                 635                 640 


Ala Gly Ala Cys Cys Gly Thr Cys Ala Cys Cys Thr Gly Cys Ala Ala 
                645                 650                 655     


Cys Gly Thr Thr Gly Cys Cys Cys Ala Cys Cys Cys Gly Gly Cys Cys 
            660                 665                 670         


Ala Gly Cys Ala Gly Cys Ala Cys Cys Ala Ala Gly Gly Thr Gly Gly 
        675                 680                 685             


Ala Cys Ala Ala Gly Ala Ala Ala Ala Thr Thr Gly Thr Gly Cys Cys 
    690                 695                 700                 


Cys Ala Gly Gly Gly Ala Thr Thr Gly Thr Gly Gly Thr Thr Gly Thr 
705                 710                 715                 720 


Ala Ala Gly Cys Cys Thr Thr Gly Cys Ala Thr Ala Thr Gly Thr Ala 
                725                 730                 735     


Cys Ala Gly Thr Cys Cys Cys Ala Gly Ala Ala Gly Thr Ala Thr Cys 
            740                 745                 750         


Ala Thr Cys Thr Gly Thr Cys Thr Thr Cys Ala Thr Cys Thr Thr Cys 
        755                 760                 765             


Cys Cys Cys Cys Cys Ala Ala Ala Gly Cys Cys Cys Ala Ala Gly Gly 
    770                 775                 780                 


Ala Thr Gly Thr Gly Cys Thr Cys Ala Cys Cys Ala Thr Thr Ala Cys 
785                 790                 795                 800 


Thr Cys Thr Gly Ala Cys Thr Cys Cys Thr Ala Ala Gly Gly Thr Cys 
                805                 810                 815     


Ala Cys Gly Thr Gly Thr Gly Thr Thr Gly Thr Gly Gly Thr Ala Gly 
            820                 825                 830         


Ala Cys Ala Thr Cys Ala Gly Cys Ala Ala Gly Gly Ala Thr Gly Ala 
        835                 840                 845             


Thr Cys Cys Cys Gly Ala Gly Gly Thr Cys Cys Ala Gly Thr Thr Cys 
    850                 855                 860                 


Ala Gly Cys Thr Gly Gly Thr Thr Thr Gly Thr Ala Gly Ala Thr Gly 
865                 870                 875                 880 


Ala Thr Gly Thr Gly Gly Ala Gly Gly Thr Gly Cys Ala Cys Ala Cys 
                885                 890                 895     


Ala Gly Cys Thr Cys Ala Gly Ala Cys Gly Cys Ala Ala Cys Cys Cys 
            900                 905                 910         


Cys Gly Gly Gly Ala Gly Gly Ala Gly Cys Ala Gly Thr Thr Cys Ala 
        915                 920                 925             


Ala Cys Ala Gly Cys Ala Cys Thr Thr Thr Cys Cys Gly Cys Thr Cys 
    930                 935                 940                 


Ala Gly Thr Cys Ala Gly Thr Gly Ala Ala Cys Thr Thr Cys Cys Cys 
945                 950                 955                 960 


Ala Thr Cys Ala Thr Gly Cys Ala Cys Cys Ala Gly Gly Ala Cys Thr 
                965                 970                 975     


Gly Gly Cys Thr Cys Ala Ala Thr Gly Gly Cys Ala Ala Gly Gly Ala 
            980                 985                 990         


Gly Thr Thr Cys Ala Ala Ala Thr  Gly Cys Ala Gly Gly  Gly Thr Cys 
        995                 1000                 1005             


Ala Ala  Cys Ala Gly Thr Gly  Cys Ala Gly Cys Thr  Thr Thr Cys 
    1010                 1015                 1020             


Cys Cys  Thr Gly Cys Cys Cys  Cys Cys Ala Thr Cys  Gly Ala Gly 
    1025                 1030                 1035             


Ala Ala  Ala Ala Cys Cys Ala  Thr Cys Thr Cys Cys  Ala Ala Ala 
    1040                 1045                 1050             


Ala Cys  Cys Ala Ala Ala Gly  Gly Cys Ala Gly Ala  Cys Cys Gly 
    1055                 1060                 1065             


Ala Ala  Gly Gly Cys Thr Cys  Cys Ala Cys Ala Gly  Gly Thr Gly 
    1070                 1075                 1080             


Thr Ala  Cys Ala Cys Cys Ala  Thr Thr Cys Cys Ala  Cys Cys Thr 
    1085                 1090                 1095             


Cys Cys  Cys Ala Ala Gly Gly  Ala Gly Cys Ala Gly  Ala Thr Gly 
    1100                 1105                 1110             


Gly Cys  Cys Ala Ala Gly Gly  Ala Thr Ala Ala Ala  Gly Thr Cys 
    1115                 1120                 1125             


Ala Gly  Thr Cys Thr Gly Ala  Cys Cys Thr Gly Cys  Ala Thr Gly 
    1130                 1135                 1140             


Ala Thr  Ala Ala Cys Ala Gly  Ala Cys Thr Thr Cys  Thr Thr Cys 
    1145                 1150                 1155             


Cys Cys  Thr Gly Ala Ala Gly  Ala Cys Ala Thr Thr  Ala Cys Thr 
    1160                 1165                 1170             


Gly Thr  Gly Gly Ala Gly Thr  Gly Gly Cys Ala Gly  Thr Gly Gly 
    1175                 1180                 1185             


Ala Ala  Thr Gly Gly Gly Cys  Ala Gly Cys Cys Ala  Gly Cys Gly 
    1190                 1195                 1200             


Gly Ala  Gly Ala Ala Cys Thr  Ala Cys Ala Ala Gly  Ala Ala Cys 
    1205                 1210                 1215             


Ala Cys  Thr Cys Ala Gly Cys  Cys Cys Ala Thr Cys  Ala Thr Gly 
    1220                 1225                 1230             


Gly Ala  Cys Ala Cys Ala Gly  Ala Thr Gly Gly Cys  Thr Cys Thr 
    1235                 1240                 1245             


Thr Ala  Cys Thr Thr Cys Ala  Thr Cys Thr Ala Cys  Ala Gly Cys 
    1250                 1255                 1260             


Ala Ala  Gly Cys Thr Cys Ala  Ala Thr Gly Thr Gly  Cys Ala Gly 
    1265                 1270                 1275             


Ala Ala  Gly Ala Gly Cys Ala  Ala Cys Thr Gly Gly  Gly Ala Gly 
    1280                 1285                 1290             


Gly Cys  Ala Gly Gly Ala Ala  Ala Thr Ala Cys Thr  Thr Thr Cys 
    1295                 1300                 1305             


Ala Cys  Cys Thr Gly Cys Thr  Cys Thr Gly Thr Gly  Thr Thr Ala 
    1310                 1315                 1320             


Cys Ala  Thr Gly Ala Gly Gly  Gly Cys Cys Thr Gly  Cys Ala Cys 
    1325                 1330                 1335             


Ala Ala  Cys Cys Ala Cys Cys  Ala Thr Ala Cys Thr  Gly Ala Gly 
    1340                 1345                 1350             


Ala Ala  Gly Ala Gly Cys Cys  Thr Cys Thr Cys Cys  Cys Ala Cys 
    1355                 1360                 1365             


Thr Cys  Thr Cys Cys Thr Gly  Gly Thr Ala Ala Ala  Thr Gly Ala 
    1370                 1375                 1380             


<210>  3
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  3

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Thr Met Ser Trp Val Arg Gln Thr Pro Ala Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Gly Asn Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Tyr Arg Ser Leu Phe Ala Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
                165                 170                 175     


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
        195                 200                 205             


Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
    210                 215                 220                 


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys 
225                 230                 235                 240 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
305                 310                 315                 320 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
                325                 330                 335     


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            340                 345                 350         


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
        355                 360                 365             


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
    370                 375                 380                 


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
385                 390                 395                 400 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
                405                 410                 415     


Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
            420                 425                 430         


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
        435                 440                 445             


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460 


<210>  4
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  4

Ala Thr Gly Cys Ala Thr Thr Thr Thr Cys Ala Ala Gly Thr Gly Cys 
1               5                   10                  15      


Ala Gly Ala Thr Thr Thr Thr Cys Ala Gly Cys Thr Thr Cys Cys Thr 
            20                  25                  30          


Gly Cys Thr Ala Ala Thr Cys Ala Gly Thr Gly Cys Cys Thr Cys Ala 
        35                  40                  45              


Gly Thr Cys Ala Thr Ala Ala Thr Gly Thr Cys Cys Ala Gly Ala Gly 
    50                  55                  60                  


Gly Ala Cys Ala Ala Ala Thr Thr Gly Thr Thr Cys Thr Cys Ala Cys 
65                  70                  75                  80  


Cys Cys Ala Gly Thr Cys Thr Cys Cys Ala Gly Cys Ala Ala Thr Cys 
                85                  90                  95      


Ala Thr Gly Thr Cys Thr Gly Cys Ala Thr Cys Thr Cys Cys Ala Gly 
            100                 105                 110         


Gly Gly Gly Ala Gly Ala Ala Gly Gly Thr Cys Ala Cys Cys Ala Thr 
        115                 120                 125             


Ala Ala Cys Cys Thr Gly Cys Ala Gly Thr Gly Cys Cys Ala Gly Cys 
    130                 135                 140                 


Thr Cys Ala Ala Gly Thr Gly Thr Ala Ala Gly Thr Thr Ala Cys Ala 
145                 150                 155                 160 


Thr Gly Cys Ala Cys Thr Gly Gly Thr Thr Cys Cys Ala Gly Cys Ala 
                165                 170                 175     


Gly Ala Ala Gly Cys Cys Ala Gly Gly Cys Ala Cys Thr Thr Cys Thr 
            180                 185                 190         


Cys Cys Cys Ala Ala Ala Cys Thr Cys Thr Gly Gly Ala Thr Thr Thr 
        195                 200                 205             


Ala Thr Ala Gly Cys Ala Cys Ala Thr Cys Cys Ala Ala Cys Cys Thr 
    210                 215                 220                 


Gly Gly Cys Thr Thr Cys Thr Gly Gly Ala Gly Thr Cys Cys Cys Thr 
225                 230                 235                 240 


Gly Cys Thr Cys Gly Cys Thr Thr Cys Ala Gly Thr Gly Gly Cys Ala 
                245                 250                 255     


Gly Thr Gly Gly Ala Thr Cys Thr Gly Gly Gly Ala Cys Cys Thr Cys 
            260                 265                 270         


Thr Thr Ala Cys Thr Cys Thr Cys Thr Cys Ala Cys Ala Ala Thr Cys 
        275                 280                 285             


Ala Gly Cys Cys Gly Ala Ala Thr Gly Gly Ala Gly Gly Cys Thr Gly 
    290                 295                 300                 


Ala Ala Gly Ala Thr Gly Cys Thr Gly Cys Cys Ala Cys Thr Thr Ala 
305                 310                 315                 320 


Thr Thr Ala Cys Thr Gly Cys Cys Ala Gly Cys Ala Ala Ala Gly Gly 
                325                 330                 335     


Ala Gly Thr Ala Gly Thr Thr Ala Cys Cys Cys Ala Thr Thr Cys Ala 
            340                 345                 350         


Cys Gly Thr Thr Cys Gly Gly Cys Thr Cys Gly Gly Gly Gly Ala Cys 
        355                 360                 365             


Ala Ala Ala Gly Thr Thr Gly Gly Ala Ala Ala Thr Ala Ala Ala Ala 
    370                 375                 380                 


Cys Gly Gly Gly Cys Thr Gly Ala Thr Gly Cys Thr Gly Cys Ala Cys 
385                 390                 395                 400 


Cys Ala Ala Cys Thr Gly Thr Ala Thr Cys Cys Ala Thr Cys Thr Thr 
                405                 410                 415     


Cys Cys Cys Ala Cys Cys Ala Thr Cys Cys Ala Gly Thr Gly Ala Gly 
            420                 425                 430         


Cys Ala Gly Thr Thr Ala Ala Cys Ala Thr Cys Thr Gly Gly Ala Gly 
        435                 440                 445             


Gly Thr Gly Cys Cys Thr Cys Ala Gly Thr Cys Gly Thr Gly Thr Gly 
    450                 455                 460                 


Cys Thr Thr Cys Thr Thr Gly Ala Ala Cys Ala Ala Cys Thr Thr Cys 
465                 470                 475                 480 


Thr Ala Cys Cys Cys Cys Ala Ala Ala Gly Ala Cys Ala Thr Cys Ala 
                485                 490                 495     


Ala Thr Gly Thr Cys Ala Ala Gly Thr Gly Gly Ala Ala Gly Ala Thr 
            500                 505                 510         


Thr Gly Ala Thr Gly Gly Cys Ala Gly Thr Gly Ala Ala Cys Gly Ala 
        515                 520                 525             


Cys Ala Ala Ala Ala Thr Gly Gly Cys Gly Thr Cys Cys Thr Gly Ala 
    530                 535                 540                 


Ala Cys Ala Gly Thr Thr Gly Gly Ala Cys Thr Gly Ala Thr Cys Ala 
545                 550                 555                 560 


Gly Gly Ala Cys Ala Gly Cys Ala Ala Ala Gly Ala Cys Ala Gly Cys 
                565                 570                 575     


Ala Cys Cys Thr Ala Cys Ala Gly Cys Ala Thr Gly Ala Gly Cys Ala 
            580                 585                 590         


Gly Cys Ala Cys Cys Cys Thr Cys Ala Cys Gly Thr Thr Gly Ala Cys 
        595                 600                 605             


Cys Ala Ala Gly Gly Ala Cys Gly Ala Gly Thr Ala Thr Gly Ala Ala 
    610                 615                 620                 


Cys Gly Ala Cys Ala Thr Ala Ala Cys Ala Gly Cys Thr Ala Thr Ala 
625                 630                 635                 640 


Cys Cys Thr Gly Thr Gly Ala Gly Gly Cys Cys Ala Cys Thr Cys Ala 
                645                 650                 655     


Cys Ala Ala Gly Ala Cys Ala Thr Cys Ala Ala Cys Thr Thr Cys Ala 
            660                 665                 670         


Cys Cys Cys Ala Thr Thr Gly Thr Cys Ala Ala Gly Ala Gly Cys Thr 
        675                 680                 685             


Thr Cys Ala Ala Cys Ala Gly Gly Ala Ala Thr Gly Ala Gly Thr Gly 
    690                 695                 700                 


Thr Thr Gly 
705         


<210>  5
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  5

Met His Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser 
    50                  55                  60                  


Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg 
            100                 105                 110         


Ser Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
                165                 170                 175     


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
        195                 200                 205             


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
    210                 215                 220                 


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235 


<210>  6
<211>  1383
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  6

Ala Thr Gly Ala Ala Cys Thr Thr Cys Gly Gly Gly Cys Thr Cys Ala 
1               5                   10                  15      


Gly Cys Thr Thr Gly Ala Thr Thr Thr Thr Cys Cys Thr Thr Gly Thr 
            20                  25                  30          


Cys Cys Thr Thr Gly Thr Thr Thr Thr Ala Ala Ala Ala Gly Gly Thr 
        35                  40                  45              


Gly Thr Cys Cys Ala Gly Thr Gly Thr Gly Ala Ala Gly Thr Gly Ala 
    50                  55                  60                  


Ala Gly Cys Thr Gly Gly Thr Gly Gly Ala Gly Thr Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Ala Gly Gly Cys Thr Thr Ala Gly Thr Gly Ala Ala Gly 
                85                  90                  95      


Cys Cys Thr Gly Gly Ala Gly Gly Gly Thr Cys Cys Cys Thr Gly Ala 
            100                 105                 110         


Ala Ala Cys Thr Cys Thr Cys Cys Thr Gly Thr Gly Cys Ala Gly Cys 
        115                 120                 125             


Cys Thr Cys Thr Gly Gly Ala Thr Thr Cys Ala Cys Thr Thr Thr Cys 
    130                 135                 140                 


Ala Gly Thr Ala Gly Cys Thr Ala Thr Ala Cys Cys Ala Thr Gly Thr 
145                 150                 155                 160 


Cys Thr Thr Gly Gly Gly Thr Thr Cys Gly Cys Cys Ala Gly Ala Cys 
                165                 170                 175     


Thr Cys Cys Gly Gly Cys Gly Ala Ala Gly Ala Gly Gly Cys Thr Gly 
            180                 185                 190         


Gly Ala Gly Thr Gly Gly Gly Thr Cys Gly Cys Ala Ala Cys Cys Ala 
        195                 200                 205             


Thr Thr Ala Gly Thr Ala Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly 
    210                 215                 220                 


Thr Ala Ala Cys Ala Cys Cys Thr Ala Cys Thr Ala Thr Cys Cys Ala 
225                 230                 235                 240 


Gly Ala Cys Ala Gly Thr Gly Thr Gly Ala Ala Gly Gly Gly Cys Cys 
                245                 250                 255     


Gly Ala Thr Thr Cys Ala Cys Cys Ala Thr Cys Thr Cys Cys Ala Gly 
            260                 265                 270         


Ala Gly Ala Cys Ala Ala Thr Gly Cys Cys Ala Gly Gly Ala Ala Cys 
        275                 280                 285             


Ala Cys Cys Cys Thr Gly Thr Ala Cys Cys Thr Gly Cys Ala Ala Ala 
    290                 295                 300                 


Thr Gly Ala Gly Cys Ala Gly Thr Cys Thr Gly Ala Gly Gly Thr Cys 
305                 310                 315                 320 


Thr Gly Ala Gly Gly Ala Cys Ala Cys Gly Gly Cys Cys Ala Thr Gly 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Gly Cys Ala Ala Gly Ala Gly 
            340                 345                 350         


Ala Cys Thr Ala Thr Ala Gly Gly Thr Cys Cys Cys Thr Gly Thr Thr 
        355                 360                 365             


Thr Gly Cys Thr Thr Ala Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala 
    370                 375                 380                 


Gly Gly Gly Ala Cys Thr Cys Thr Gly Gly Thr Cys Ala Cys Thr Gly 
385                 390                 395                 400 


Thr Cys Thr Cys Thr Gly Cys Ala Gly Cys Cys Ala Ala Ala Ala Cys 
                405                 410                 415     


Gly Ala Cys Ala Cys Cys Cys Cys Cys Ala Thr Cys Thr Gly Thr Cys 
            420                 425                 430         


Thr Ala Thr Cys Cys Ala Cys Thr Gly Gly Cys Cys Cys Cys Thr Gly 
        435                 440                 445             


Gly Ala Thr Cys Thr Gly Cys Thr Gly Cys Cys Cys Ala Ala Ala Cys 
    450                 455                 460                 


Thr Ala Ala Cys Thr Cys Cys Ala Thr Gly Gly Thr Gly Ala Cys Cys 
465                 470                 475                 480 


Cys Thr Gly Gly Gly Ala Thr Gly Cys Cys Thr Gly Gly Thr Cys Ala 
                485                 490                 495     


Ala Gly Gly Gly Cys Thr Ala Thr Thr Thr Cys Cys Cys Thr Gly Ala 
            500                 505                 510         


Gly Cys Cys Ala Gly Thr Gly Ala Cys Ala Gly Thr Gly Ala Cys Cys 
        515                 520                 525             


Thr Gly Gly Ala Ala Cys Thr Cys Thr Gly Gly Ala Thr Cys Cys Cys 
    530                 535                 540                 


Thr Gly Thr Cys Cys Ala Gly Cys Gly Gly Thr Gly Thr Gly Cys Ala 
545                 550                 555                 560 


Cys Ala Cys Cys Thr Thr Cys Cys Cys Ala Gly Cys Thr Gly Thr Cys 
                565                 570                 575     


Cys Thr Gly Cys Ala Gly Thr Cys Thr Gly Ala Cys Cys Thr Cys Thr 
            580                 585                 590         


Ala Cys Ala Cys Thr Cys Thr Gly Ala Gly Cys Ala Gly Cys Thr Cys 
        595                 600                 605             


Ala Gly Thr Gly Ala Cys Thr Gly Thr Cys Cys Cys Cys Thr Cys Cys 
    610                 615                 620                 


Ala Gly Cys Ala Cys Cys Thr Gly Gly Cys Cys Cys Ala Gly Cys Gly 
625                 630                 635                 640 


Ala Gly Ala Cys Cys Gly Thr Cys Ala Cys Cys Thr Gly Cys Ala Ala 
                645                 650                 655     


Cys Gly Thr Thr Gly Cys Cys Cys Ala Cys Cys Cys Gly Gly Cys Cys 
            660                 665                 670         


Ala Gly Cys Ala Gly Cys Ala Cys Cys Ala Ala Gly Gly Thr Gly Gly 
        675                 680                 685             


Ala Cys Ala Ala Gly Ala Ala Ala Ala Thr Thr Gly Thr Gly Cys Cys 
    690                 695                 700                 


Cys Ala Gly Gly Gly Ala Thr Thr Gly Thr Gly Gly Thr Thr Gly Thr 
705                 710                 715                 720 


Ala Ala Gly Cys Cys Thr Thr Gly Cys Ala Thr Ala Thr Gly Thr Ala 
                725                 730                 735     


Cys Ala Gly Thr Cys Cys Cys Ala Gly Ala Ala Gly Thr Ala Thr Cys 
            740                 745                 750         


Ala Thr Cys Thr Gly Thr Cys Thr Thr Cys Ala Thr Cys Thr Thr Cys 
        755                 760                 765             


Cys Cys Cys Cys Cys Ala Ala Ala Gly Cys Cys Cys Ala Ala Gly Gly 
    770                 775                 780                 


Ala Thr Gly Thr Gly Cys Thr Cys Ala Cys Cys Ala Thr Thr Ala Cys 
785                 790                 795                 800 


Thr Cys Thr Gly Ala Cys Thr Cys Cys Thr Ala Ala Gly Gly Thr Cys 
                805                 810                 815     


Ala Cys Gly Thr Gly Thr Gly Thr Thr Gly Thr Gly Gly Thr Ala Gly 
            820                 825                 830         


Ala Cys Ala Thr Cys Ala Gly Cys Ala Ala Gly Gly Ala Thr Gly Ala 
        835                 840                 845             


Thr Cys Cys Cys Gly Ala Gly Gly Thr Cys Cys Ala Gly Thr Thr Cys 
    850                 855                 860                 


Ala Gly Cys Thr Gly Gly Thr Thr Thr Gly Thr Ala Gly Ala Thr Gly 
865                 870                 875                 880 


Ala Thr Gly Thr Gly Gly Ala Gly Gly Thr Gly Cys Ala Cys Ala Cys 
                885                 890                 895     


Ala Gly Cys Thr Cys Ala Gly Ala Cys Gly Cys Ala Ala Cys Cys Cys 
            900                 905                 910         


Cys Gly Gly Gly Ala Gly Gly Ala Gly Cys Ala Gly Thr Thr Cys Ala 
        915                 920                 925             


Ala Cys Ala Gly Cys Ala Cys Thr Thr Thr Cys Cys Gly Cys Thr Cys 
    930                 935                 940                 


Ala Gly Thr Cys Ala Gly Thr Gly Ala Ala Cys Thr Thr Cys Cys Cys 
945                 950                 955                 960 


Ala Thr Cys Ala Thr Gly Cys Ala Cys Cys Ala Gly Gly Ala Cys Thr 
                965                 970                 975     


Gly Gly Cys Thr Cys Ala Ala Thr Gly Gly Cys Ala Ala Gly Gly Ala 
            980                 985                 990         


Gly Thr Thr Cys Ala Ala Ala Thr  Gly Cys Ala Gly Gly  Gly Thr Cys 
        995                 1000                 1005             


Ala Ala  Cys Ala Gly Thr Gly  Cys Ala Gly Cys Thr  Thr Thr Cys 
    1010                 1015                 1020             


Cys Cys  Thr Gly Cys Cys Cys  Cys Cys Ala Thr Cys  Gly Ala Gly 
    1025                 1030                 1035             


Ala Ala  Ala Ala Cys Cys Ala  Thr Cys Thr Cys Cys  Ala Ala Ala 
    1040                 1045                 1050             


Ala Cys  Cys Ala Ala Ala Gly  Gly Cys Ala Gly Ala  Cys Cys Gly 
    1055                 1060                 1065             


Ala Ala  Gly Gly Cys Thr Cys  Cys Ala Cys Ala Gly  Gly Thr Gly 
    1070                 1075                 1080             


Thr Ala  Cys Ala Cys Cys Ala  Thr Thr Cys Cys Ala  Cys Cys Thr 
    1085                 1090                 1095             


Cys Cys  Cys Ala Ala Gly Gly  Ala Gly Cys Ala Gly  Ala Thr Gly 
    1100                 1105                 1110             


Gly Cys  Cys Ala Ala Gly Gly  Ala Thr Ala Ala Ala  Gly Thr Cys 
    1115                 1120                 1125             


Ala Gly  Thr Cys Thr Gly Ala  Cys Cys Thr Gly Cys  Ala Thr Gly 
    1130                 1135                 1140             


Ala Thr  Ala Ala Cys Ala Gly  Ala Cys Thr Thr Cys  Thr Thr Cys 
    1145                 1150                 1155             


Cys Cys  Thr Gly Ala Ala Gly  Ala Cys Ala Thr Thr  Ala Cys Thr 
    1160                 1165                 1170             


Gly Thr  Gly Gly Ala Gly Thr  Gly Gly Cys Ala Gly  Thr Gly Gly 
    1175                 1180                 1185             


Ala Ala  Thr Gly Gly Gly Cys  Ala Gly Cys Cys Ala  Gly Cys Gly 
    1190                 1195                 1200             


Gly Ala  Gly Ala Ala Cys Thr  Ala Cys Ala Ala Gly  Ala Ala Cys 
    1205                 1210                 1215             


Ala Cys  Thr Cys Ala Gly Cys  Cys Cys Ala Thr Cys  Ala Thr Gly 
    1220                 1225                 1230             


Gly Ala  Cys Ala Cys Ala Gly  Ala Thr Gly Gly Cys  Thr Cys Thr 
    1235                 1240                 1245             


Thr Ala  Cys Thr Thr Cys Ala  Thr Cys Thr Ala Cys  Ala Gly Cys 
    1250                 1255                 1260             


Ala Ala  Gly Cys Thr Cys Ala  Ala Thr Gly Thr Gly  Cys Ala Gly 
    1265                 1270                 1275             


Ala Ala  Gly Ala Gly Cys Ala  Ala Cys Thr Gly Gly  Gly Ala Gly 
    1280                 1285                 1290             


Gly Cys  Ala Gly Gly Ala Ala  Ala Thr Ala Cys Thr  Thr Thr Cys 
    1295                 1300                 1305             


Ala Cys  Cys Thr Gly Cys Thr  Cys Thr Gly Thr Gly  Thr Thr Ala 
    1310                 1315                 1320             


Cys Ala  Thr Gly Ala Gly Gly  Gly Cys Cys Thr Gly  Cys Ala Cys 
    1325                 1330                 1335             


Ala Ala  Cys Cys Ala Cys Cys  Ala Thr Ala Cys Thr  Gly Ala Gly 
    1340                 1345                 1350             


Ala Ala  Gly Ala Gly Cys Cys  Thr Cys Thr Cys Cys  Cys Ala Cys 
    1355                 1360                 1365             


Thr Cys  Thr Cys Cys Thr Gly  Gly Thr Ala Ala Ala  Thr Gly Ala 
    1370                 1375                 1380             


<210>  7
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  7

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Thr Met Ser Trp Val Arg Gln Thr Pro Ala Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Gly Asn Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Tyr Arg Ser Leu Phe Ala Tyr Trp Gly Gln 
        115                 120                 125             


Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val 
    130                 135                 140                 


Tyr Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr 
145                 150                 155                 160 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr 
                165                 170                 175     


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val 
            180                 185                 190         


Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser 
        195                 200                 205             


Ser Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala 
    210                 215                 220                 


Ser Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys 
225                 230                 235                 240 


Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro 
305                 310                 315                 320 


Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val 
                325                 330                 335     


Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            340                 345                 350         


Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys 
        355                 360                 365             


Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp 
    370                 375                 380                 


Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro 
385                 390                 395                 400 


Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser 
                405                 410                 415     


Tyr Phe Ile Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala 
            420                 425                 430         


Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His 
        435                 440                 445             


His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455                 460 


<210>  8
<211>  707
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  8

Ala Thr Gly Cys Ala Thr Thr Thr Thr Cys Ala Ala Gly Thr Gly Cys 
1               5                   10                  15      


Ala Gly Ala Thr Thr Thr Thr Cys Ala Gly Cys Thr Thr Cys Cys Thr 
            20                  25                  30          


Gly Cys Thr Ala Ala Thr Cys Ala Gly Thr Gly Cys Cys Thr Cys Ala 
        35                  40                  45              


Gly Thr Cys Ala Thr Ala Ala Thr Gly Thr Cys Cys Ala Gly Ala Gly 
    50                  55                  60                  


Gly Ala Cys Ala Ala Ala Thr Thr Gly Thr Thr Cys Thr Cys Ala Cys 
65                  70                  75                  80  


Cys Cys Ala Gly Thr Cys Thr Cys Cys Ala Gly Cys Ala Ala Thr Cys 
                85                  90                  95      


Ala Thr Gly Thr Cys Thr Gly Cys Ala Thr Cys Thr Cys Cys Ala Gly 
            100                 105                 110         


Gly Gly Gly Ala Gly Ala Ala Gly Gly Thr Cys Ala Cys Cys Ala Thr 
        115                 120                 125             


Ala Ala Cys Cys Thr Gly Cys Ala Gly Thr Gly Cys Cys Ala Gly Cys 
    130                 135                 140                 


Thr Cys Ala Ala Gly Thr Gly Thr Ala Ala Gly Thr Thr Ala Cys Ala 
145                 150                 155                 160 


Thr Gly Cys Ala Cys Thr Gly Gly Thr Thr Cys Cys Ala Gly Cys Ala 
                165                 170                 175     


Gly Ala Ala Gly Cys Cys Ala Gly Gly Cys Ala Cys Thr Thr Cys Thr 
            180                 185                 190         


Cys Cys Cys Ala Ala Ala Cys Thr Cys Thr Gly Gly Ala Thr Thr Thr 
        195                 200                 205             


Ala Thr Ala Gly Cys Ala Cys Ala Thr Cys Cys Ala Ala Cys Cys Thr 
    210                 215                 220                 


Gly Gly Cys Thr Thr Cys Thr Gly Gly Ala Gly Thr Cys Cys Cys Thr 
225                 230                 235                 240 


Gly Cys Thr Cys Gly Cys Thr Thr Cys Ala Gly Thr Gly Gly Cys Ala 
                245                 250                 255     


Gly Thr Gly Gly Ala Thr Cys Thr Gly Gly Gly Ala Cys Cys Thr Cys 
            260                 265                 270         


Thr Thr Ala Cys Thr Cys Thr Cys Thr Cys Ala Cys Ala Ala Thr Cys 
        275                 280                 285             


Ala Gly Cys Cys Gly Ala Ala Thr Gly Gly Ala Gly Gly Cys Thr Gly 
    290                 295                 300                 


Ala Ala Gly Ala Thr Gly Cys Thr Gly Cys Cys Ala Cys Thr Thr Ala 
305                 310                 315                 320 


Thr Thr Ala Cys Thr Gly Cys Cys Ala Gly Cys Ala Ala Ala Gly Gly 
                325                 330                 335     


Ala Gly Thr Ala Gly Thr Thr Ala Cys Cys Cys Ala Thr Thr Cys Ala 
            340                 345                 350         


Cys Gly Thr Thr Cys Gly Gly Cys Thr Cys Gly Gly Gly Gly Ala Cys 
        355                 360                 365             


Ala Ala Ala Gly Thr Thr Gly Gly Ala Ala Ala Thr Ala Ala Ala Ala 
    370                 375                 380                 


Cys Gly Gly Gly Cys Thr Gly Ala Thr Gly Cys Thr Gly Cys Ala Cys 
385                 390                 395                 400 


Cys Ala Ala Cys Thr Gly Thr Ala Thr Cys Cys Ala Thr Cys Thr Thr 
                405                 410                 415     


Cys Cys Cys Ala Cys Cys Ala Thr Cys Cys Ala Gly Thr Gly Ala Gly 
            420                 425                 430         


Cys Ala Gly Thr Thr Ala Ala Cys Ala Thr Cys Thr Gly Gly Ala Gly 
        435                 440                 445             


Gly Thr Gly Cys Cys Thr Cys Ala Gly Thr Cys Gly Thr Gly Thr Gly 
    450                 455                 460                 


Cys Thr Thr Cys Thr Thr Gly Ala Ala Cys Ala Ala Cys Thr Thr Cys 
465                 470                 475                 480 


Thr Ala Cys Cys Cys Cys Ala Ala Ala Gly Ala Cys Ala Thr Cys Ala 
                485                 490                 495     


Ala Thr Gly Thr Cys Ala Ala Gly Thr Gly Gly Ala Ala Gly Ala Thr 
            500                 505                 510         


Thr Gly Ala Thr Gly Gly Cys Ala Gly Thr Gly Ala Ala Cys Gly Ala 
        515                 520                 525             


Cys Ala Ala Ala Ala Thr Gly Gly Cys Gly Thr Cys Cys Thr Gly Ala 
    530                 535                 540                 


Ala Cys Ala Gly Thr Thr Gly Gly Ala Cys Thr Gly Ala Thr Cys Ala 
545                 550                 555                 560 


Gly Gly Ala Cys Ala Gly Cys Ala Ala Ala Gly Ala Cys Ala Gly Cys 
                565                 570                 575     


Ala Cys Cys Thr Ala Cys Ala Gly Cys Ala Thr Gly Ala Gly Cys Ala 
            580                 585                 590         


Gly Cys Ala Cys Cys Cys Thr Cys Ala Cys Gly Thr Thr Gly Ala Cys 
        595                 600                 605             


Cys Ala Ala Gly Gly Ala Cys Gly Ala Gly Thr Ala Thr Gly Ala Ala 
    610                 615                 620                 


Cys Gly Ala Cys Ala Thr Ala Ala Cys Ala Gly Cys Thr Ala Thr Ala 
625                 630                 635                 640 


Cys Cys Thr Gly Thr Gly Ala Gly Gly Cys Cys Ala Cys Thr Cys Ala 
                645                 650                 655     


Cys Ala Ala Gly Ala Cys Ala Thr Cys Ala Ala Cys Thr Thr Cys Ala 
            660                 665                 670         


Cys Cys Cys Ala Thr Thr Gly Thr Cys Ala Ala Gly Ala Gly Cys Thr 
        675                 680                 685             


Thr Cys Ala Ala Cys Ala Gly Gly Ala Ala Thr Gly Ala Gly Thr Gly 
    690                 695                 700                 


Thr Thr Gly 
705         


<210>  9
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  9

Met His Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile 
            20                  25                  30          


Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys Ser Ala Ser 
        35                  40                  45              


Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro Gly Thr Ser 
    50                  55                  60                  


Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg 
            100                 105                 110         


Ser Ser Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
    130                 135                 140                 


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
                165                 170                 175     


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
        195                 200                 205             


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
    210                 215                 220                 


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235 


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  10

Ser Tyr Thr Met Ser 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  11

Thr Ile Ser Ser Gly Gly Gly Asn Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  12

Asp Tyr Arg Ser Leu Phe Ala Tyr 
1               5               


<210>  13
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  13

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  14

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  15

Gln Gln Arg Ser Ser Tyr Pro Phe Thr 
1               5                   


<210>  16
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  16

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met Ser Trp Val Arg Gln Thr Pro Ala Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Ser Gly Gly Gly Asn Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Arg Ser Leu Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  17
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  17

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Phe Gln Gln Lys Pro Gly Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Ser Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  18
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  18

Gly Ala Lys Lys Val Phe Tyr Val Ile Glu Thr Arg Glu Pro Arg Glu 
1               5                   10                  15      


Arg Leu 
        


<210>  19
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  19

Asp Ser Glu Ala Leu His Pro Leu Gly Met Ala Val Lys Ser Ser 
1               5                   10                  15  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  20

Asp Ser Glu Ala Leu His Pro Leu Gly Met Ala Val Lys Ser Ser 
1               5                   10                  15  


