                         SEQUENCE LISTING

<110>  Woods, Elliot C
       Xiao, Han
       Bertozzi, Carolyn R
       Gray, Melissa
 
<120>  CONJUGATES FOR TARGETED CELL SURFACE EDITING

<130>  STAN-1302WO

<150>  62357645
<151>  2016-07-01

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  1

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  2
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  3
<211>  381
<212>  PRT
<213>  Salmonella typhimurium sialidase

<400>  3

Thr Val Glu Lys Ser Val Val Phe Lys Ala Glu Gly Glu His Phe Thr 
1               5                   10                  15      


Asp Gln Lys Gly Asn Thr Ile Val Gly Ser Gly Ser Gly Gly Thr Thr 
            20                  25                  30          


Lys Tyr Phe Arg Ile Pro Ala Met Cys Thr Thr Ser Lys Gly Thr Ile 
        35                  40                  45              


Val Val Phe Ala Asp Ala Arg His Asn Thr Ala Ser Asp Gln Ser Phe 
    50                  55                  60                  


Ile Asp Thr Ala Ala Ala Arg Ser Thr Asp Gly Gly Lys Thr Trp Asn 
65                  70                  75                  80  


Lys Lys Ile Ala Ile Tyr Asn Asp Arg Val Asn Ser Lys Leu Ser Arg 
                85                  90                  95      


Val Met Asp Pro Thr Cys Ile Val Ala Asn Ile Gln Gly Arg Glu Thr 
            100                 105                 110         


Ile Leu Val Met Val Gly Lys Trp Asn Asn Asn Asp Lys Thr Trp Gly 
        115                 120                 125             


Ala Tyr Arg Asp Lys Ala Pro Asp Thr Asp Trp Asp Leu Val Leu Tyr 
    130                 135                 140                 


Lys Ser Thr Asp Asp Gly Val Thr Phe Ser Lys Val Glu Thr Asn Ile 
145                 150                 155                 160 


His Asp Ile Val Thr Lys Asn Gly Thr Ile Ser Ala Met Leu Gly Gly 
                165                 170                 175     


Val Gly Ser Gly Leu Gln Leu Asn Asp Gly Lys Leu Val Phe Pro Val 
            180                 185                 190         


Gln Met Val Arg Thr Lys Asn Ile Thr Thr Val Leu Asn Thr Ser Phe 
        195                 200                 205             


Ile Tyr Ser Thr Asp Gly Ile Thr Trp Ser Leu Pro Ser Gly Tyr Cys 
    210                 215                 220                 


Glu Gly Phe Gly Ser Glu Asn Asn Ile Ile Glu Phe Asn Ala Ser Leu 
225                 230                 235                 240 


Val Asn Asn Ile Arg Asn Ser Gly Leu Arg Arg Ser Phe Glu Thr Lys 
                245                 250                 255     


Asp Phe Gly Lys Thr Trp Thr Glu Phe Pro Pro Met Asp Lys Lys Val 
            260                 265                 270         


Asp Asn Arg Asn His Gly Val Gln Gly Ser Thr Ile Thr Ile Pro Ser 
        275                 280                 285             


Gly Asn Lys Leu Val Ala Ala His Ser Ser Ala Gln Asn Lys Asn Asn 
    290                 295                 300                 


Asp Tyr Thr Arg Ser Asp Ile Ser Leu Tyr Ala His Asn Leu Tyr Ser 
305                 310                 315                 320 


Gly Glu Val Lys Leu Ile Asp Asp Phe Tyr Pro Lys Val Gly Asn Ala 
                325                 330                 335     


Ser Gly Ala Gly Tyr Ser Cys Leu Ser Tyr Arg Lys Asn Val Asp Lys 
            340                 345                 350         


Glu Thr Leu Tyr Val Val Tyr Glu Ala Asn Gly Ser Ile Glu Phe Gln 
        355                 360                 365             


Asp Leu Ser Arg His Leu Pro Val Ile Lys Ser Tyr Asn 
    370                 375                 380     


<210>  4
<211>  757
<212>  PRT
<213>  Vibrio cholerae sialidase

<400>  4

Ala Leu Phe Asp Tyr Asn Ala Thr Gly Asp Thr Glu Phe Asp Ser Pro 
1               5                   10                  15      


Ala Lys Gln Gly Trp Met Gln Asp Asn Thr Asn Asn Gly Ser Gly Val 
            20                  25                  30          


Leu Thr Asn Ala Asp Gly Met Pro Ala Trp Leu Val Gln Gly Ile Gly 
        35                  40                  45              


Gly Arg Ala Gln Trp Thr Tyr Ser Leu Ser Thr Asn Gln His Ala Gln 
    50                  55                  60                  


Ala Ser Ser Phe Gly Trp Arg Met Thr Thr Glu Met Lys Val Leu Ser 
65                  70                  75                  80  


Gly Gly Met Ile Thr Asn Tyr Tyr Ala Asn Gly Thr Gln Arg Val Leu 
                85                  90                  95      


Pro Ile Ile Ser Leu Asp Ser Ser Gly Asn Leu Val Val Glu Phe Glu 
            100                 105                 110         


Gly Gln Thr Gly Arg Thr Val Leu Ala Thr Gly Thr Ala Ala Thr Glu 
        115                 120                 125             


Tyr His Lys Phe Glu Leu Val Phe Leu Pro Gly Ser Asn Pro Ser Ala 
    130                 135                 140                 


Ser Phe Tyr Phe Asp Gly Lys Leu Ile Arg Asp Asn Ile Gln Pro Thr 
145                 150                 155                 160 


Ala Ser Lys Gln Asn Met Ile Val Trp Gly Asn Gly Ser Ser Asn Thr 
                165                 170                 175     


Asp Gly Val Ala Ala Tyr Arg Asp Ile Lys Phe Glu Ile Gln Gly Asp 
            180                 185                 190         


Val Ile Phe Arg Gly Pro Asp Arg Ile Pro Ser Ile Val Ala Ser Ser 
        195                 200                 205             


Val Thr Pro Gly Val Val Thr Ala Phe Ala Glu Lys Arg Val Gly Gly 
    210                 215                 220                 


Gly Asp Pro Gly Ala Leu Ser Asn Thr Asn Asp Ile Ile Thr Arg Thr 
225                 230                 235                 240 


Ser Arg Asp Gly Gly Ile Thr Trp Asp Thr Glu Leu Asn Leu Thr Glu 
                245                 250                 255     


Gln Ile Asn Val Ser Asp Glu Phe Asp Phe Ser Asp Pro Arg Pro Ile 
            260                 265                 270         


Tyr Asp Pro Ser Ser Asn Thr Val Leu Val Ser Tyr Ala Arg Trp Pro 
        275                 280                 285             


Thr Asp Ala Ala Gln Asn Gly Asp Arg Ile Lys Pro Trp Met Pro Asn 
    290                 295                 300                 


Gly Ile Phe Tyr Ser Val Tyr Asp Val Ala Ser Gly Asn Trp Gln Ala 
305                 310                 315                 320 


Pro Ile Asp Val Thr Asp Gln Val Lys Glu Arg Ser Phe Gln Ile Ala 
                325                 330                 335     


Gly Trp Gly Gly Ser Glu Leu Tyr Arg Arg Asn Thr Ser Leu Asn Ser 
            340                 345                 350         


Gln Gln Asp Trp Gln Ser Asn Ala Lys Ile Arg Ile Val Asp Gly Ala 
        355                 360                 365             


Ala Asn Gln Ile Gln Val Ala Asp Gly Ser Arg Lys Tyr Val Val Thr 
    370                 375                 380                 


Leu Ser Ile Asp Glu Ser Gly Gly Leu Val Ala Asn Leu Asn Gly Val 
385                 390                 395                 400 


Ser Ala Pro Ile Ile Leu Gln Ser Glu His Ala Lys Val His Ser Phe 
                405                 410                 415     


His Asp Tyr Glu Leu Gln Tyr Ser Ala Leu Asn His Thr Thr Thr Leu 
            420                 425                 430         


Phe Val Asp Gly Gln Gln Ile Thr Thr Trp Ala Gly Glu Val Ser Gln 
        435                 440                 445             


Glu Asn Asn Ile Gln Phe Gly Asn Ala Asp Ala Gln Ile Asp Gly Arg 
    450                 455                 460                 


Leu His Val Gln Lys Ile Val Leu Thr Gln Gln Gly His Asn Leu Val 
465                 470                 475                 480 


Glu Phe Asp Ala Phe Tyr Leu Ala Gln Gln Thr Pro Glu Val Glu Lys 
                485                 490                 495     


Asp Leu Glu Lys Leu Gly Trp Thr Lys Ile Lys Thr Gly Asn Thr Met 
            500                 505                 510         


Ser Leu Tyr Gly Asn Ala Ser Val Asn Pro Gly Pro Gly His Gly Ile 
        515                 520                 525             


Thr Leu Thr Arg Gln Gln Asn Ile Ser Gly Ser Gln Asn Gly Arg Leu 
    530                 535                 540                 


Ile Tyr Pro Ala Ile Val Leu Asp Arg Phe Phe Leu Asn Val Met Ser 
545                 550                 555                 560 


Ile Tyr Ser Asp Asp Gly Gly Ser Asn Trp Gln Thr Gly Ser Thr Leu 
                565                 570                 575     


Pro Ile Pro Phe Arg Trp Lys Ser Ser Ser Ile Leu Glu Thr Leu Glu 
            580                 585                 590         


Pro Ser Glu Ala Asp Met Val Glu Leu Gln Asn Gly Asp Leu Leu Leu 
        595                 600                 605             


Thr Ala Arg Leu Asp Phe Asn Gln Ile Val Asn Gly Val Asn Tyr Ser 
    610                 615                 620                 


Pro Arg Gln Gln Phe Leu Ser Lys Asp Gly Gly Ile Thr Trp Ser Leu 
625                 630                 635                 640 


Leu Glu Ala Asn Asn Ala Asn Val Phe Ser Asn Ile Ser Thr Gly Thr 
                645                 650                 655     


Val Asp Ala Ser Ile Thr Arg Phe Glu Gln Ser Asp Gly Ser His Phe 
            660                 665                 670         


Leu Leu Phe Thr Asn Pro Gln Gly Asn Pro Ala Gly Thr Asn Gly Arg 
        675                 680                 685             


Gln Asn Leu Gly Leu Trp Phe Ser Phe Asp Glu Gly Val Thr Trp Lys 
    690                 695                 700                 


Gly Pro Ile Gln Leu Val Asn Gly Ala Ser Ala Tyr Ser Asp Ile Tyr 
705                 710                 715                 720 


Gln Leu Asp Ser Glu Asn Ala Ile Val Ile Val Glu Thr Asp Asn Ser 
                725                 730                 735     


Asn Met Arg Ile Leu Arg Met Pro Ile Thr Leu Leu Lys Gln Lys Leu 
            740                 745                 750         


Thr Leu Ser Gln Asn 
        755         


