                         SEQUENCE LISTING

<110>  SUNY Upstate Medical University
 
<120>  COMPOSITIONS AND METHODS FOR MODIFYING ACTIVITY OF EXTRACELLULAR 
       MMP-2

<130>  075098.00031

<150>  62/356,797
<151>  2016-06-30

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  220
<212>  PRT
<213>  human

<400>  1

Met Gly Ala Ala Ala Arg Thr Leu Arg Leu Ala Leu Gly Leu Leu Leu 
1               5                   10                  15      


Leu Ala Thr Leu Leu Arg Pro Ala Asp Ala Cys Ser Cys Ser Pro Val 
            20                  25                  30          


His Pro Gln Gln Ala Phe Cys Asn Ala Asp Val Val Ile Arg Ala Lys 
        35                  40                  45              


Ala Val Ser Glu Lys Glu Val Asp Ser Gly Asn Asp Ile Tyr Gly Asn 
    50                  55                  60                  


Pro Ile Lys Arg Ile Gln Tyr Glu Ile Lys Gln Ile Lys Met Phe Lys 
65                  70                  75                  80  


Gly Pro Glu Lys Asp Ile Glu Phe Ile Tyr Thr Ala Pro Ser Ser Ala 
                85                  90                  95      


Val Cys Gly Val Ser Leu Asp Val Gly Gly Lys Lys Glu Tyr Leu Ile 
            100                 105                 110         


Ala Gly Lys Ala Glu Gly Asp Gly Lys Met His Ile Thr Leu Cys Asp 
        115                 120                 125             


Phe Ile Val Pro Trp Asp Thr Leu Ser Thr Thr Gln Lys Lys Ser Leu 
    130                 135                 140                 


Asn His Arg Tyr Gln Met Gly Cys Glu Cys Lys Ile Thr Arg Cys Pro 
145                 150                 155                 160 


Met Ile Pro Cys Tyr Ile Ser Ser Pro Asp Glu Cys Leu Trp Met Asp 
                165                 170                 175     


Trp Val Thr Glu Lys Asn Ile Asn Gly His Gln Ala Lys Phe Phe Ala 
            180                 185                 190         


Cys Ile Lys Arg Ser Asp Gly Ser Cys Ala Trp Tyr Arg Gly Ala Ala 
        195                 200                 205             


Pro Pro Lys Gln Glu Phe Leu Asp Ile Glu Asp Pro 
    210                 215                 220 


<210>  2
<211>  207
<212>  PRT
<213>  human

<400>  2

Met Ala Pro Phe Glu Pro Leu Ala Ser Gly Ile Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ile Ala Pro Ser Arg Ala Cys Thr Cys Val Pro Pro His Pro Gln 
            20                  25                  30          


Thr Ala Phe Cys Asn Ser Asp Leu Val Ile Arg Ala Lys Phe Val Gly 
        35                  40                  45              


Thr Pro Glu Val Asn Gln Thr Thr Leu Tyr Gln Arg Tyr Glu Ile Lys 
    50                  55                  60                  


Met Thr Lys Met Tyr Lys Gly Phe Gln Ala Leu Gly Asp Ala Ala Asp 
65                  70                  75                  80  


Ile Arg Phe Val Tyr Thr Pro Ala Met Glu Ser Val Cys Gly Tyr Phe 
                85                  90                  95      


His Arg Ser His Asn Arg Ser Glu Glu Phe Leu Ile Ala Gly Lys Leu 
            100                 105                 110         


Gln Asp Gly Leu Leu His Ile Thr Thr Cys Ser Phe Val Ala Pro Trp 
        115                 120                 125             


Asn Ser Leu Ser Leu Ala Gln Arg Arg Gly Phe Thr Lys Thr Tyr Thr 
    130                 135                 140                 


Val Gly Cys Glu Glu Cys Thr Val Phe Pro Cys Leu Ser Ile Pro Cys 
145                 150                 155                 160 


Lys Leu Gln Ser Gly Thr His Cys Leu Trp Thr Asp Gln Leu Leu Gln 
                165                 170                 175     


Gly Ser Glu Lys Gly Phe Gln Ser Arg His Leu Ala Cys Leu Pro Arg 
            180                 185                 190         


Glu Pro Gly Leu Cys Thr Trp Gln Ser Leu Arg Ser Gln Ile Ala 
        195                 200                 205         


<210>  3
<211>  211
<212>  PRT
<213>  human

<400>  3

Met Thr Pro Trp Leu Gly Leu Ile Val Leu Leu Gly Ser Trp Ser Leu 
1               5                   10                  15      


Gly Asp Trp Gly Ala Glu Ala Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210>  4
<211>  224
<212>  PRT
<213>  human

<400>  4

Met Pro Gly Ser Pro Arg Pro Ala Pro Ser Trp Val Leu Leu Leu Arg 
1               5                   10                  15      


Leu Leu Ala Leu Leu Arg Pro Pro Gly Leu Gly Glu Ala Cys Ser Cys 
            20                  25                  30          


Ala Pro Ala His Pro Gln Gln His Ile Cys His Ser Ala Leu Val Ile 
        35                  40                  45              


Arg Ala Lys Ile Ser Ser Glu Lys Val Val Pro Ala Ser Ala Asp Pro 
    50                  55                  60                  


Ala Asp Thr Glu Lys Met Leu Arg Tyr Glu Ile Lys Gln Ile Lys Met 
65                  70                  75                  80  


Phe Lys Gly Phe Glu Lys Val Lys Asp Val Gln Tyr Ile Tyr Thr Pro 
                85                  90                  95      


Phe Asp Ser Ser Leu Cys Gly Val Lys Leu Glu Ala Asn Ser Gln Lys 
            100                 105                 110         


Gln Tyr Leu Leu Thr Gly Gln Val Leu Ser Asp Gly Lys Val Phe Ile 
        115                 120                 125             


His Leu Cys Asn Tyr Ile Glu Pro Trp Glu Asp Leu Ser Leu Val Gln 
    130                 135                 140                 


Arg Glu Ser Leu Asn His His Tyr His Leu Asn Cys Gly Cys Gln Ile 
145                 150                 155                 160 


Thr Thr Cys Tyr Thr Val Pro Cys Thr Ile Ser Ala Pro Asn Glu Cys 
                165                 170                 175     


Leu Trp Thr Asp Trp Leu Leu Glu Arg Lys Leu Tyr Gly Tyr Gln Ala 
            180                 185                 190         


Gln His Tyr Val Cys Met Lys His Val Asp Gly Thr Cys Ser Trp Tyr 
        195                 200                 205             


Arg Gly His Leu Pro Leu Arg Lys Glu Phe Val Asp Ile Val Gln Pro 
    210                 215                 220                 


<210>  5
<211>  27
<212>  PRT
<213>  human

<400>  5

Gly Gly Val Thr Thr Phe Val Ala Leu Tyr Asp Tyr Glu Ser Arg Thr 
1               5                   10                  15      


Glu Thr Asp Leu Ser Phe Lys Lys Gly Glu Arg 
            20                  25          


