                         SEQUENCE LISTING

<110>  University of Massachusetts
       Massachusetts Eye and Ear Infirmary
 
<120>  AAV2-MEDIATED GENE DELIVERY OF SFASL AS A NEUROPROTECTIVE THERAPY
        IN GLAUCOMA

<130>  U0120.70085WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 62/511,629
<151>  2017-05-26

<150>  US 62/358,541
<151>  2016-07-05

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  735
<212>  PRT
<213>  adeno-associated virus 2

<400>  1

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  2
<211>  465
<212>  DNA
<213>  Homo Sapiens

<400>  2
gagaagcaaa taggccaccc cagtccaccc cctgaaaaaa aggagctgag gaaagtggcc       60

catttaacag gcaagtccaa ctcaaggtcc atgcctctgg aatgggaaga cacctatgga      120

attgtcctgc tttctggagt gaagtataag aagggtggcc ttgtgatcaa tgaaactggg      180

ctgtactttg tatattccaa agtatacttc cggggtcaat cttgcaacaa cctgcccctg      240

agccacaagg tctacatgag gaactctaag tatccccagg atctggtgat gatggagggg      300

aagatgatga gctactgcac tactgggcag atgtgggccc gcagcagcta cctgggggca      360

gtgttcaatc ttaccagtgc tgatcattta tatgtcaacg tatctgagct ctctctggtc      420

aattttgagg aatctcagac gtttttcggc ttatataagc tctaa                      465


<210>  3
<211>  154
<212>  PRT
<213>  Homo Sapiens

<400>  3

Glu Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu 
1               5                   10                  15      


Arg Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro 
            20                  25                  30          


Leu Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys 
        35                  40                  45              


Tyr Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val 
    50                  55                  60                  


Tyr Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu 
65                  70                  75                  80  


Ser His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val 
                85                  90                  95      


Met Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp 
            100                 105                 110         


Ala Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp 
        115                 120                 125             


His Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu 
    130                 135                 140                 


Ser Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
145                 150                 


<210>  4
<211>  359
<212>  DNA
<213>  Simian virus 40

<400>  4
tctccccccc ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag       60

cgatgggggc gggggggggg gggggggggg cgcgcgccag gcggggcggg gcggggcgag      120

gggcggggcg gggcgaggcg gagaggtgcg gcggcagcca atcagagcgg cgcgctccga      180

aagtttcctt ttatggcgag gcggcggcgg cggcggccct ataaaaagcg aagcgcgcgg      240

cgggcgggag cgggatcagc caccgcggtg gcggccctag agtcgatcga ggaactgaaa      300

aaccagaaag ttaactggta agtttagtct ttttgtcttt tatttcaggt cccggatcc       359


<210>  5
<211>  9276
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  5
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gacgcgcgag cgagcgagtg      120

actccggcgg gcccgtttcg ggcccgcagc ccgctggaaa ccagcgggcc ggagtcactc      180

gctcgctcgc gcgtctctcc gagtgtagcc atgctctagg aagatcaatt cggtacaatt      240

cacgcgtcga cattgattat tgactctggt cgttacataa cttacggtaa atggcccgcc      300

ctcacatcgg tacgagatcc ttctagttaa gccatgttaa gtgcgcagct gtaactaata      360

actgagacca gcaatgtatt gaatgccatt taccgggcgg tggctgaccg cccaacgacc      420

ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag ggactttcca      480

ttgacgtcaa tgggtggagt accgactggc gggttgctgg ggcgggtaac tgcagttatt      540

actgcataca agggtatcat tgcggttatc cctgaaaggt aactgcagtt acccacctat      600

ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct      660

attgacgtca atgacggtaa atggcccgcc tggcattata aatgccattt gacgggtgaa      720

ccgtcatgta gttcacatag tatacggttc atgcggggga taactgcagt tactgccatt      780

taccgggcgg accgtaattg cccagtacat gaccttatgg gactttccta cttggcagta      840

catctactcg aggccacgtt ctgcttcact ctccccatct cccccccctc cccaccccac      900

gggtcatgta ctggaatacc ctgaaaggat gaaccgtcat gtagatgagc tccggtgcaa      960

gacgaagtga gaggggtaga ggggggggag gggtggggca attttgtatt tatttatttt     1020

ttaattattt tgtgcagcga tgggggcggg gggggggggg gggggggcgc gcgccaggcg     1080

gggcggggcg gggcgagggt taaaacataa ataaataaaa aattaataaa acacgtcgct     1140

acccccgccc cccccccccc cccccccgcg cgcggtccgc cccgccccgc cccgctccgg     1200

cggggcgggg cgaggcggag aggtgcggcg gcagccaatc agagcggcgc gctccgaaag     1260

tttcctttta tggcgaggcg gcggcggcgg cggccctacc gccccgcccc gctccgcctc     1320

tccacgccgc cgtcggttag tctcgccgcg cgaggctttc aaaggaaaat accgctccgc     1380

cgccgccgcc gccgggatta aaaagcgaag cgcgcggcgg gcgggagcgg gatcagccac     1440

cgcggtggcg gccctagagt cgatcgagga actgaaaaac cagaaagtta actggtaaat     1500

ttttcgcttc gcgcgccgcc cgccctcgcc ctagtcggtg gcgccaccgc cgggatctca     1560

gctagctcct tgactttttg gtctttcaat tgaccattgt ttagtctttt tgtcttttat     1620

ttcaggtccc cggatccatg gctcaacttt ctgcccagag gcgcatgaag ctaatggccc     1680

tgcagctgct gctgtggcca aatcagaaaa acagaaaata aagtccaggg gcctaggtac     1740

cgagttgaaa gacgggtctc cgcgtacttc gattaccggg acgtcgacga cgacaccgaa     1800

agtgcactat ggtcaggacg agaggccgtt cccctggtca ctgtcagcgc tctggaattc     1860

gaaaagcaaa tagccaaccc cagtacaccc tctgaaaatt tcacgtgata ccagtcctgc     1920

tctccggcaa ggggaccagt gacagtcgcg agaccttaag cttttcgttt atcggttggg     1980

gtcatgtggg agacttttaa aagagccgag gagtgtggcc catttaacag ggaaccccca     2040

ctcaaggtcc atccctctgg aatgggaaga cacatatgga accgctctga tctctggatt     2100

ttctcggctc ctcacaccgg gtaaattgtc ccttgggggt gagttccagg tagggagacc     2160

ttacccttct gtgtatacct tggcgagact agagacctgt gaagtataag aaaggtggcc     2220

ttgtgatcaa cgaaactggg ttgtacttcg tgtattccaa agtatacttc cggggtcagt     2280

cctgcaacaa ccagccccca cttcatattc tttccaccgg aacactagtt gctttgaccc     2340

aacatgaagc acataaggtt tcatatgaag gccccagtca ggacgttgtt ggtcggggta     2400

aaccacaagg tctatatgag gaactctaag tatcctgagg atctggtgct aatggaggag     2460

aagaggttga actactgcac tactggacag atatgggcat ttggtgttcc agatatactc     2520

cttgagattc ataggactcc tagaccacga ttacctcctc ttctccaact tgatgacgtg     2580

atgacctgtc tatacccgcc acagcagcta cctgggggca gtattcaatc ttaccagtgc     2640

tgaccattta tatgtcaaca tatctcaact ctctctgatc aattttgagg aatctaaggg     2700

tgtcgtcgat ggacccccgt cataagttag aatggtcacg actggtaaat atacagttgt     2760

atagagttga gagagactag ttaaaactcc ttagattcac ctttttcggc ttatataagc     2820

ttatcgatac cgtcgactag agctcgctga tcagcctcga ctgtgccttc tagttgccag     2880

ccatctgttg tttgcccctg gaaaaagccg aatatattcg aatagctatg gcagctgatc     2940

tcgagcgact agtcggagct gacacggaag atcaacggtc ggtagacaac aaacggggtc     3000

ccccgtgcct tccttgaccc tggaaggtgc cactcccact gtcctttcct aataaaatga     3060

ggaaattgca tcgcattgtc tgagtaggtg tcattctaag ggggcacgga aggaactggg     3120

accttccacg gtgagggtga caggaaagga ttattttact cctttaacgt agcgtaacag     3180

actcatccac agtaagattt ctggggggtg gggtggggca ggacagcaag ggggaggatt     3240

gggaagacaa ttaggtagat aagtagcatg gcgggttaat cattaactac aaggaaccaa     3300

gaccccccac cccaccccgt cctgtcgttc cccctcctaa cccttctgtt aatccatcta     3360

ttcatcgtac cgcccaatta gtaattgatg ttccttggcc tagtgatgga gttggccact     3420

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     3480

ggctttgccc gggcggccgg atcactacct caaccggtga gggagagacg cgcgagcgag     3540

cgagtgactc cggcccgctg gtttccagcg ggctgcgggc ccgaaacggg cccgccggtc     3600

agtgagcgag cgagcgcgca gccttaatta acctaattca ctggccgtcg ttttacaacg     3660

tcgtgactgg gaaaaccctg gcgttaccca acttaatcag tcactcgctc gctcgcgcgt     3720

cggaattaat tggattaagt gaccggcagc aaaatgttgc agcactgacc cttttgggac     3780

cgcaatgggt tgaattaggc cttgcagcac atcccccttt cgccagctgg cgtaatagcg     3840

aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg     3900

gaacgtcgtg tagggggaaa gcggtcgacc gcattatcgc ttctccgggc gtggctagcg     3960

ggaagggttg tcaacgcgtc ggacttaccg cttaccctcg cgccctgtag cggcgcatta     4020

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     4080

cccgctcctt tcgctttcgc gcgggacatc gccgcgtaat tcgcgccgcc cacaccacca     4140

atgcgcgtcg cactggcgat gtgaacggtc gcgggatcgc gggcgaggaa agcgaaagtt     4200

cccttccttt ctcgccacgt tcgccggctt tccccgtcaa gctctaaatc gggggctccc     4260

tttagggttc cgatttagtg ctttacggca cctcgaccaa gggaaggaaa gagcggtgca     4320

agcggccgaa aggggcagtt cgagatttag cccccgaggg aaatcccaag gctaaatcac     4380

gaaatgccgt ggagctggcc aaaaaacttg attagggtga tggttcacgt agtgggccat     4440

cgccctgata gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtgggg     4500

ttttttgaac taatcccact accaagtgca tcacccggta gcgggactat ctgccaaaaa     4560

gcgggaaact gcaacctcag gtgcaagaaa ttatcaccac tcttgttcca aactggaaca     4620

acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc     4680

tattggttaa aaaatgagtg agaacaaggt ttgaccttgt tgtgagttgg gatagagcca     4740

gataagaaaa ctaaatattc cctaaaacgg ctaaagccgg ataaccaatt ttttactcct     4800

gatttaacaa aaatttaacg cgaattttaa caaaatatta acgcttacaa tttaggtggc     4860

acttttcggg gaaatgtgcg cggaacccct atttgtttga ctaaattgtt tttaaattgc     4920

gcttaaaatt gttttataat tgcgaatgtt aaatccaccg tgaaaagccc ctttacacgc     4980

gccttgggga taaacaaaat ttttctaaat acattcaaat atgtatccgc tcatgagaca     5040

ataaccctga taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacatta     5100

aaaagattta tgtaagttta tacataggcg agtactctgt tattgggact atttacgaag     5160

ttattataac tttttccttc tcatactcat aagttgtatt ccgtgtcgcc cttattccct     5220

tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg aaagtaaaag     5280

atgctgaaga tcagttggaa ggcacagcgg gaataaggga aaaaacgccg taaaacggaa     5340

ggacaaaaac gagtgggtct ttgcgaccac tttcattttc tacgacttct agtcaaccgt     5400

gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc     5460

cccgaagaac gttttccaat gatgagcact tttaaagtca cgtgctcacc caatgtagct     5520

tgacctagag ttgtcgccat tctaggaact ctcaaaagcg gggcttcttg caaaaggtta     5580

ctactcgtga aaatttcatc tgctatgtgg cgcggtatta tcccgtattg acgccgggca     5640

agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccaag     5700

acgatacacc gcgccataat agggcataac tgcggcccgt tctcgttgag ccagcggcgt     5760

atgtgataag agtcttactg aaccaactca tgagtggtgt cacagaaaag catcttacgg     5820

atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat aacactgcgg     5880

ccaacttact tctgacaaca gtgtcttttc gtagaatgcc taccgtactg tcattctctt     5940

aatacgtcac gacggtattg gtactcacta ttgtgacgcc ggttgaatga agactgttcg     6000

atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc     6060

cttgatcgtt gggaaccgga gctgaatgaa gccataccgc tagcctcctg gcttcctcga     6120

ttggcgaaaa aacgtgttgt accccctagt acattgagcg gaactagcaa cccttggcct     6180

cgacttactt cggtatggaa acgacgagcg tgacaccacg atgcctgtag caatggcaac     6240

aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc aacaattatt     6300

tgctgctcgc actgtggtgc tacggacatc gttaccgttg ttgcaacgcg tttgataatt     6360

gaccgcttga tgaatgagat cgaagggccg ttgttaatat agactggatg gaggcggata     6420

aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt gctgataaat     6480

ctggagccgg tgagcgtgta tctgacctac ctccgcctat ttcaacgtcc tggtgaagac     6540

gcgagccggg aaggccgacc gaccaaataa cgactattta gacctcggcc actcgcacgg     6600

tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc     6660

tacacgacgg ggagtcaggc aactatggat gaacgaaacc agagcgccat agtaacgtcg     6720

tgaccccggt ctaccattcg ggagggcata gcatcaatag atgtgctgcc cctcagtccg     6780

ttgataccta cttgctttta gacagatcgc tgagataggt gcctcactga ttaagcattg     6840

gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac ttcattttat     6900

ctgtctagcg actctatcca cggagtgact aattcgtaac cattgacagt ctggttcaaa     6960

tgagtatata tgaaatctaa ctaaattttg aagtaaaata atttaaaagg atctaggtga     7020

agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag     7080

cgtcagaccc cgtagaaaat taaattttcc tagatccact tctaggaaaa actattagag     7140

tactggtttt agggaattgc actcaaaagc aaggtgactc gcagtctggg gcatctttag     7200

atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa     7260

aaaccaccgc taccagcggt ggtttgtttg ccggatcatc tagtttccta gaagaactct     7320

aggaaaaaaa gacgcgcatt agacgacgaa cgtttgtttt tttggtggcg atggtcgcca     7380

ccaaacaaac ggcctagtag agctaccaac tctttttccg aaggtaactg gcttcagcag     7440

agcgcagata ccaaatactg ttcttctagt gtagccgtag ttaggccacc acttcaagtc     7500

tcgatggttg agaaaaaggc ttccattgac cgaagtcgtc tcgcgtctat ggtttatgac     7560

aagaagatca catcggcatc aatccggtgg tgaagttcaa ctctgtagca ccgcctacat     7620

acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta     7680

ccgggttgga ctcaagactt gagacatcgt ggcggatgta tggagcgaga cgattaggac     7740

aatggtcacc gacgacggtc accgctattc agcacagaat ggcccaacct gagttctgga     7800

tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc     7860

ttggagcgaa cgacctacac cgaactgaga tacctacact atcaatggcc tattccgcgt     7920

cgccagcccg acttgccccc caagcacgtg tgtcgggtcg aacctcgctt gctggatgtg     7980

gcttgactct atggatgtgc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa     8040

ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcg     8100

cactcgatac tctttcgcgg tgcgaagggc ttccctcttt ccgcctgtcc ataggccatt     8160

cgccgtccca gccttgtcct ctcgcgtgct ccctcgaacc agggggaaac gcctggtatc     8220

tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg tgatgctcgt     8280

caggggggcg gagcctatgg tccccctttg cggaccatag aaatatcagg acagcccaaa     8340

gcggtggaga ctgaactcgc agctaaaaac actacgagca gtccccccgc ctcggatagg     8400

aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac     8460

atgttctttc ctgcgttatc ccctgattct gtggataacc tttttgcggt cgttgcgccg     8520

gaaaaatgcc aaggaccgga aaacgaccgg aaaacgagtg tacaagaaag gacgcaatag     8580

gggactaaga cacctattcc gtattaccgc ctttgagtga gctgataccg ctcgccgcag     8640

ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc caatacgcgg     8700

cataatggcg gaaactcact cgactatggc gagcggcgtc ggcttgctgg ctcgcgtcgc     8760

tcagtcactc gctccttcgc cttctcgcgg gttatgcgaa accgcctctc cccgcgcgtt     8820

ggccgattca ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc     8880

gcaacgcaat taatgtgatt tggcggagag gggcgcgcaa ccggctaagt aattacgtcg     8940

accgtgctgt ccaaagggct gacctttcgc ccgtcactcg cgttgcgtta attacacttc     9000

attaggcacc ccaggcttta cactttatgc ttccggctcg tatgttgtgt ggaattgtga     9060

gcggataaca atttcacaca ggaaacagca atcgagtgag taatccgtgg ggtccgaaat     9120

gtgaaatacg aaggccgagc atacaacaca ccttaacact cgcctattgt taaagtgtgt     9180

cctttgtcct atgaccatga ttacgccaga tttaattaag gccttaatta gggatactgg     9240

tactaatgcg gtctaaatta attccggaat taatcc                               9276


<210>  6
<211>  281
<212>  PRT
<213>  Homo Sapiens

<400>  6

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210>  7
<211>  846
<212>  DNA
<213>  Homo Sapiens

<400>  7
atgcagcagc ccttcaatta cccatatccc cagatctact gggtggacag cagtgccagc       60

tctccctggg cccctccagg cacagttctt ccctgtccaa cctctgtgcc cagaaggcct      120

ggtcaaagga ggccaccacc accaccgcca ccgccaccac taccacctcc gccgccgccg      180

ccaccactgc ctccactacc gctgccaccc ctgaagaaga gagggaacca cagcacaggc      240

ctgtgtctcc ttgtgatgtt tttcatggtt ctggttgcct tggtaggatt gggcctgggg      300

atgtttcagc tcttccacct acagaaggag ctggcagaac tccgagagtc taccagccag      360

atgcacacag catcatcttt ggagaagcaa ataggccacc ccagtccacc ccctgaaaaa      420

aaggagctga ggaaagtggc ccatttaaca ggcaagtcca actcaaggtc catgcctctg      480

gaatgggaag acacctatgg aattgtcctg ctttctggag tgaagtataa gaagggtggc      540

cttgtgatca atgaaactgg gctgtacttt gtatattcca aagtatactt ccggggtcaa      600

tcttgcaaca acctgcccct gagccacaag gtctacatga ggaactctaa gtatccccag      660

gatctggtga tgatggaggg gaagatgatg agctactgca ctactgggca gatgtgggcc      720

cgcagcagct acctgggggc agtgttcaat cttaccagtg ctgatcattt atatgtcaac      780

gtatctgagc tctctctggt caattttgag gaatctcaga cgtttttcgg cttatataag      840

ctctaa                                                                 846


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
gggacagtga cctggactgt                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  9
ctccctttgc agaactcagg                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
tgttaccaac tgggacgaca                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  11
cttttcacgg ttggccttag                                                   20


<210>  12
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
ttctgatata gggtcctgc                                                    19


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  13
tcaccagatc caagaaactc                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  14
caagctgagt gtaactgaag                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  15
ttaaaaggca tcagcaagag                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  16
ggcgctcaat gctggcttca                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  17
tctgcctcca gcctcaggtt                                                   20


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  18
agggtttcat ccaggatcga gcag                                              24


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  19
atcttccaga tggtgagcga g                                                 21


<210>  20
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  20
ttgtggcctt ctttgagttc ggtg                                              24


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  21
ggtgccggtt caggtactca gtca                                              24


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  22
gaagttcccg gtttcctctc                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  23
gagggcagga tctctcagtg                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  24
tgtcagccaa gttcaagctg                                                   20


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  25
atcttccgaa ctttctccag gg                                                22


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  26
tgggtagaca gcagtgccac                                                   20


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  27
gcccacaaga tggacaggg                                                    19


<210>  28
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  28
gtcctgcctc tggtgcttgc tg                                                22


<210>  29
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  29
caggttggca tggttga                                                      17


