                         SEQUENCE LISTING

<110>  Brandeis University
 
<120>  COMPOSITIONS AND METHODS FOR IDENTIFYING RNA BINDING POLYPEPTIDE 
       TARGETS

<130>  167703.011101

<140>  PCT/US2016/054525
<141>  2016-09-29

<150>  62/364,170
<151>  2016-07-19

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  334
<212>  PRT
<213>  Drosophila melanogaster

<400>  1

Met Asn Gly Tyr Asn Arg Lys Leu Pro Gln Lys Arg Gly Tyr Glu Met 
1               5                   10                  15      


Pro Lys Tyr Ser Asp Pro Lys Lys Lys Met Cys Lys Glu Arg Ile Pro 
            20                  25                  30          


Gln Pro Lys Asn Thr Val Ala Met Leu Asn Glu Leu Arg His Gly Leu 
        35                  40                  45              


Ile Tyr Lys Leu Glu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe 
    50                  55                  60                  


Thr Ile Ser Val Glu Val Asp Gly Gln Lys Tyr Leu Gly Gln Gly Arg 
65                  70                  75                  80  


Ser Lys Lys Val Ala Arg Ile Glu Ala Ala Ala Thr Ala Leu Arg Ser 
                85                  90                  95      


Phe Ile Gln Phe Lys Asp Gly Ala Val Leu Ser Pro Leu Lys Pro Ala 
            100                 105                 110         


Gly Asn Leu Asp Phe Thr Ser Asp Glu His Leu Glu Asn Asp Val Ser 
        115                 120                 125             


Lys Ser Ala Ile Thr Val Asp Gly Gln Lys Lys Val Pro Asp Lys Gly 
    130                 135                 140                 


Pro Val Met Leu Leu Tyr Glu Leu Phe Asn Asp Val Asn Phe Glu Cys 
145                 150                 155                 160 


Ile Asn Ile Asp Gly Ala Gln Asn Asn Cys Arg Phe Lys Met Thr Val 
                165                 170                 175     


Thr Ile Asn Glu Lys Lys Phe Asp Gly Thr Gly Pro Ser Lys Lys Thr 
            180                 185                 190         


Ala Lys Asn Ala Ala Ala Lys Ala Ala Leu Ala Ser Leu Cys Asn Ile 
        195                 200                 205             


Ser Tyr Ser Pro Met Val Val Pro Gln Lys Asn Val Pro Leu Pro Ile 
    210                 215                 220                 


Asp Asp Lys Ser Ser Ser Met Glu Leu Pro Gln Ile His Ala Asp Thr 
225                 230                 235                 240 


Ile Gly Arg Leu Val Leu Glu Lys Phe Met Glu Val Ile Lys Gly Gln 
                245                 250                 255     


Glu Ala Tyr Ser Arg Arg Lys Val Leu Ala Gly Ile Val Met Thr Glu 
            260                 265                 270         


Asn Met Asn Phe Cys Glu Ala Lys Val Ile Ser Val Ser Thr Gly Thr 
        275                 280                 285             


Lys Cys Val Ser Gly Glu His Met Ser Val Asn Gly Ala Val Leu Asn 
    290                 295                 300                 


Asp Ser His Ala Glu Ile Val Ser Arg Arg Cys Leu Leu Lys Tyr Leu 
305                 310                 315                 320 


Tyr Ala Gln Leu Asp Leu Gln Cys Asn Gln Gly Ile Val Val 
                325                 330                 


<210>  2
<211>  1851
<212>  DNA
<213>  Drosophila melanogaster

<400>  2
tattgtgata actgctcaca tcgctagatt ccgagcaaca aaaaagcgac gaagggtcat       60

tgttattttt tctaatgcaa tgtaatgcag caaatgtgca gatttgaaca agtgtaacgc      120

gatttatgtt taatccgcat cgaggaacca aatcgaagta aacgcgcggc cagagaaaag      180

agcagcaccg caccgaagat aaaacaaaca agcattgatt tgtttgtccg gccatgtcag      240

tgtgtgtgtc acaagggctt gcaagtgtgt gcgtgtgtcc gtgcgtgtac gtgggtgctt      300

ttttttttct cccgagtgcc gccaagtgaa atatgcaatt gcacgccact gcagttgcag      360

ccacacaaat cctatcctaa tcgacgaaac agcgaagcga ggaggctaga atcggctgcc      420

caacgaagag agcagaaccg ttaacaaatg acactctgcc gatacagcga agtaaaaatc      480

aataattaga gcaaaaagcc ggtgagtgca ccatccgata tcaacatgaa tggctataac      540

cgaaaattgc cacaaaaacg tggctatgag atgccaaaat actctgatcc aaaaaagaaa      600

atgtgcaagg agcgcattcc ccagccgaag aacacggtgg ccatgctgaa tgagctaaga      660

catggactga tttacaaatt ggagtcacag actggtccgg tacacgcacc tctattcacg      720

atatccgtgg aggtcgatgg acagaaatac ttgggccagg gccgtagtaa aaaagttgca      780

cgcatcgaag cagcagcaac tgcactgcgc agctttatac agtttaagga tggagcagtt      840

ctgtcgcctc tgaagccggc gggcaacttg gactttacca gcgatgaaca tcttgaaaat      900

gatgtcagca aaagtgctat tactgttgac ggtcagaaga aggttccaga taagggtcct      960

gtcatgctcc tctacgaatt atttaatgac gttaatttcg aatgcattaa tattgacggc     1020

gcccagaaca attgtcgctt caaaatgacc gtcacaatca acgaaaagaa gttcgatgga     1080

acaggtcctt ccaaaaagac ggcgaaaaat gcggcagcta aggcggcact tgcttcgtta     1140

tgcaatattt cctacagtcc aatggtggtg ccacagaaga acgtacccct gccaatcgac     1200

gacaagtcgt catcgatgga gttgcctcag atacacgcgg atacgattgg tcggttggtc     1260

ttagaaaagt tcatggaagt aatcaagggc caggaggctt actcgcgtcg aaaggtatta     1320

gcgggcattg taatgactga aaacatgaat ttttgtgaag ccaaagttat ttcagtttcg     1380

acgggcacca agtgtgtcag cggtgagcat atgagtgtga acggagctgt cctaaatgat     1440

tcccatgctg aaatagtctc caggcgttgt cttctcaaat atttatatgc acagctggac     1500

cttcagtgca atcagggtat agttgtttga tgtatatgct aagttcagtt tacgtatact     1560

aataatacca tagaacttaa atctaagagt aatgcataat ctagttgtta aatgttgata     1620

tcgaaaatgt acgctttacc agcaagaatt gcctacatag aagctaaagt tccgatttgt     1680

gctcattaac cgtatacgag cacaaacttt tattttttct ttcttttaca cattataaac     1740

aagcacttta agctaactta tgttttcccc gtctgatcgt tttagaaggt gtttatacaa     1800

aattaaattt taagggcaaa ccatcttaaa aataaacaat ttgtaaacat t              1851


<210>  3
<211>  905
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Glu Ile Lys Glu Lys Ile Cys Asp Tyr Leu Phe Asn Val Ser 
1               5                   10                  15      


Asp Ser Ser Ala Leu Asn Leu Ala Lys Asn Ile Gly Leu Thr Lys Ala 
            20                  25                  30          


Arg Asp Ile Asn Ala Val Leu Ile Asp Met Glu Arg Gln Gly Asp Val 
        35                  40                  45              


Tyr Arg Gln Gly Thr Thr Pro Pro Ile Trp His Leu Thr Asp Lys Lys 
    50                  55                  60                  


Arg Glu Arg Met Gln Ile Lys Arg Asn Thr Asn Ser Val Pro Glu Thr 
65                  70                  75                  80  


Ala Pro Ala Ala Ile Pro Glu Thr Lys Arg Asn Ala Glu Phe Leu Thr 
                85                  90                  95      


Cys Asn Ile Pro Thr Ser Asn Ala Ser Asn Asn Met Val Thr Thr Glu 
            100                 105                 110         


Lys Val Glu Asn Gly Gln Glu Pro Val Ile Lys Leu Glu Asn Arg Gln 
        115                 120                 125             


Glu Ala Arg Pro Glu Pro Ala Arg Leu Lys Pro Pro Val His Tyr Asn 
    130                 135                 140                 


Gly Pro Ser Lys Ala Gly Tyr Val Asp Phe Glu Asn Gly Gln Trp Ala 
145                 150                 155                 160 


Thr Asp Asp Ile Pro Asp Asp Leu Asn Ser Ile Arg Ala Ala Pro Gly 
                165                 170                 175     


Glu Phe Arg Ala Ile Met Glu Met Pro Ser Phe Tyr Ser His Gly Leu 
            180                 185                 190         


Pro Arg Cys Ser Pro Tyr Lys Lys Leu Thr Glu Cys Gln Leu Lys Asn 
        195                 200                 205             


Pro Ile Ser Gly Leu Leu Glu Tyr Ala Gln Phe Ala Ser Gln Thr Cys 
    210                 215                 220                 


Glu Phe Asn Met Ile Glu Gln Ser Gly Pro Pro His Glu Pro Arg Phe 
225                 230                 235                 240 


Lys Phe Gln Val Val Ile Asn Gly Arg Glu Phe Pro Pro Ala Glu Ala 
                245                 250                 255     


Gly Ser Lys Lys Val Ala Lys Gln Asp Ala Ala Met Lys Ala Met Thr 
            260                 265                 270         


Ile Leu Leu Glu Glu Ala Lys Ala Lys Asp Ser Gly Lys Ser Glu Glu 
        275                 280                 285             


Ser Ser His Tyr Ser Thr Glu Lys Glu Ser Glu Lys Thr Ala Glu Ser 
    290                 295                 300                 


Gln Thr Pro Thr Pro Ser Ala Thr Ser Phe Phe Ser Gly Lys Ser Pro 
305                 310                 315                 320 


Val Thr Thr Leu Leu Glu Cys Met His Lys Leu Gly Asn Ser Cys Glu 
                325                 330                 335     


Phe Arg Leu Leu Ser Lys Glu Gly Pro Ala His Glu Pro Lys Phe Gln 
            340                 345                 350         


Tyr Cys Val Ala Val Gly Ala Gln Thr Phe Pro Ser Val Ser Ala Pro 
        355                 360                 365             


Ser Lys Lys Val Ala Lys Gln Met Ala Ala Glu Glu Ala Met Lys Ala 
    370                 375                 380                 


Leu His Gly Glu Ala Thr Asn Ser Met Ala Ser Asp Asn Gln Pro Glu 
385                 390                 395                 400 


Gly Met Ile Ser Glu Ser Leu Asp Asn Leu Glu Ser Met Met Pro Asn 
                405                 410                 415     


Lys Val Arg Lys Ile Gly Glu Leu Val Arg Tyr Leu Asn Thr Asn Pro 
            420                 425                 430         


Val Gly Gly Leu Leu Glu Tyr Ala Arg Ser His Gly Phe Ala Ala Glu 
        435                 440                 445             


Phe Lys Leu Val Asp Gln Ser Gly Pro Pro His Glu Pro Lys Phe Val 
    450                 455                 460                 


Tyr Gln Ala Lys Val Gly Gly Arg Trp Phe Pro Ala Val Cys Ala His 
465                 470                 475                 480 


Ser Lys Lys Gln Gly Lys Gln Glu Ala Ala Asp Ala Ala Leu Arg Val 
                485                 490                 495     


Leu Ile Gly Glu Asn Glu Lys Ala Glu Arg Met Gly Phe Thr Glu Leu 
            500                 505                 510         


Pro Leu Thr Gly Ser Thr Phe His Asp Gln Ile Ala Met Leu Ser His 
        515                 520                 525             


Arg Cys Phe Asn Thr Leu Thr Asn Ser Phe Gln Pro Ser Leu Leu Gly 
    530                 535                 540                 


Arg Lys Ile Leu Ala Ala Ile Ile Met Lys Lys Asp Ser Glu Asp Met 
545                 550                 555                 560 


Gly Val Val Val Ser Leu Gly Thr Gly Asn Arg Cys Val Lys Gly Asp 
                565                 570                 575     


Ser Leu Ser Leu Lys Gly Glu Thr Val Asn Asp Cys His Ala Glu Ile 
            580                 585                 590         


Ile Ser Arg Arg Gly Phe Ile Arg Phe Leu Tyr Ser Glu Leu Met Lys 
        595                 600                 605             


Tyr Asn Ser Gln Thr Ala Lys Asp Ser Ile Phe Glu Pro Ala Lys Gly 
    610                 615                 620                 


Gly Glu Lys Leu Gln Ile Lys Lys Thr Val Ser Phe His Leu Tyr Ile 
625                 630                 635                 640 


Ser Thr Ala Pro Cys Gly Asp Gly Ala Leu Phe Asp Lys Ser Cys Ser 
                645                 650                 655     


Asp Arg Ala Met Glu Ser Thr Glu Ser Arg His Tyr Pro Val Phe Glu 
            660                 665                 670         


Asn Pro Lys Gln Gly Lys Leu Arg Thr Lys Val Glu Asn Gly Glu Gly 
        675                 680                 685             


Thr Ile Pro Val Glu Ser Ser Asp Ile Val Pro Thr Trp Asp Gly Ile 
    690                 695                 700                 


Arg Leu Gly Glu Arg Leu Arg Thr Met Ser Cys Ser Asp Lys Ile Leu 
705                 710                 715                 720 


Arg Trp Asn Val Leu Gly Leu Gln Gly Ala Leu Leu Thr His Phe Leu 
                725                 730                 735     


Gln Pro Ile Tyr Leu Lys Ser Val Thr Leu Gly Tyr Leu Phe Ser Gln 
            740                 745                 750         


Gly His Leu Thr Arg Ala Ile Cys Cys Arg Val Thr Arg Asp Gly Ser 
        755                 760                 765             


Ala Phe Glu Asp Gly Leu Arg His Pro Phe Ile Val Asn His Pro Lys 
    770                 775                 780                 


Val Gly Arg Val Ser Ile Tyr Asp Ser Lys Arg Gln Ser Gly Lys Thr 
785                 790                 795                 800 


Lys Glu Thr Ser Val Asn Trp Cys Leu Ala Asp Gly Tyr Asp Leu Glu 
                805                 810                 815     


Ile Leu Asp Gly Thr Arg Gly Thr Val Asp Gly Pro Arg Asn Glu Leu 
            820                 825                 830         


Ser Arg Val Ser Lys Lys Asn Ile Phe Leu Leu Phe Lys Lys Leu Cys 
        835                 840                 845             


Ser Phe Arg Tyr Arg Arg Asp Leu Leu Arg Leu Ser Tyr Gly Glu Ala 
    850                 855                 860                 


Lys Lys Ala Ala Arg Asp Tyr Glu Thr Ala Lys Asn Tyr Phe Lys Lys 
865                 870                 875                 880 


Gly Leu Lys Asp Met Gly Tyr Gly Asn Trp Ile Ser Lys Pro Gln Glu 
                885                 890                 895     


Glu Lys Asn Phe Tyr Leu Cys Pro Val 
            900                 905 


<210>  4
<211>  674
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Ile Glu Asp Glu Glu Asn Met Ser Ser Ser Ser Thr Asp Val 
1               5                   10                  15      


Lys Glu Asn Arg Asn Leu Asp Asn Val Ser Pro Lys Asp Gly Ser Thr 
            20                  25                  30          


Pro Gly Pro Gly Glu Gly Ser Gln Leu Ser Asn Gly Gly Gly Gly Gly 
        35                  40                  45              


Pro Gly Arg Lys Arg Pro Leu Glu Glu Gly Ser Asn Gly His Ser Lys 
    50                  55                  60                  


Tyr Arg Leu Lys Lys Arg Arg Lys Thr Pro Gly Pro Val Leu Pro Lys 
65                  70                  75                  80  


Asn Ala Leu Met Gln Leu Asn Glu Ile Lys Pro Gly Leu Gln Tyr Thr 
                85                  90                  95      


Leu Leu Ser Gln Thr Gly Pro Val His Ala Pro Leu Phe Val Met Ser 
            100                 105                 110         


Val Glu Val Asn Gly Gln Val Phe Glu Gly Ser Gly Pro Thr Lys Lys 
        115                 120                 125             


Lys Ala Lys Leu His Ala Ala Glu Lys Ala Leu Arg Ser Phe Val Gln 
    130                 135                 140                 


Phe Pro Asn Ala Ser Glu Ala His Leu Ala Met Gly Arg Thr Leu Ser 
145                 150                 155                 160 


Val Asn Thr Asp Phe Thr Ser Asp Gln Ala Asp Phe Pro Asp Thr Leu 
                165                 170                 175     


Phe Asn Gly Phe Glu Thr Pro Asp Lys Ala Glu Pro Pro Phe Tyr Val 
            180                 185                 190         


Gly Ser Asn Gly Asp Asp Ser Phe Ser Ser Ser Gly Asp Leu Ser Leu 
        195                 200                 205             


Ser Ala Ser Pro Val Pro Ala Ser Leu Ala Gln Pro Pro Leu Pro Val 
    210                 215                 220                 


Leu Pro Pro Phe Pro Pro Pro Ser Gly Lys Asn Pro Val Met Ile Leu 
225                 230                 235                 240 


Asn Glu Leu Arg Pro Gly Leu Lys Tyr Asp Phe Leu Ser Glu Ser Gly 
                245                 250                 255     


Glu Ser His Ala Lys Ser Phe Val Met Ser Val Val Val Asp Gly Gln 
            260                 265                 270         


Phe Phe Glu Gly Ser Gly Arg Asn Lys Lys Leu Ala Lys Ala Arg Ala 
        275                 280                 285             


Ala Gln Ser Ala Leu Ala Ala Ile Phe Asn Leu His Leu Asp Gln Thr 
    290                 295                 300                 


Pro Ser Arg Gln Pro Ile Pro Ser Glu Gly Leu Gln Leu His Leu Pro 
305                 310                 315                 320 


Gln Val Leu Ala Asp Ala Val Ser Arg Leu Val Leu Gly Lys Phe Gly 
                325                 330                 335     


Asp Leu Thr Asp Asn Phe Ser Ser Pro His Ala Arg Arg Lys Val Leu 
            340                 345                 350         


Ala Gly Val Val Met Thr Thr Gly Thr Asp Val Lys Asp Ala Lys Val 
        355                 360                 365             


Ile Ser Val Ser Thr Gly Thr Lys Cys Ile Asn Gly Glu Tyr Met Ser 
    370                 375                 380                 


Asp Arg Gly Leu Ala Leu Asn Asp Cys His Ala Glu Ile Ile Ser Arg 
385                 390                 395                 400 


Arg Ser Leu Leu Arg Phe Leu Tyr Thr Gln Leu Glu Leu Tyr Leu Asn 
                405                 410                 415     


Asn Lys Asp Asp Gln Lys Arg Ser Ile Phe Gln Lys Ser Glu Arg Gly 
            420                 425                 430         


Gly Phe Arg Leu Lys Glu Asn Val Gln Phe His Leu Tyr Ile Ser Thr 
        435                 440                 445             


Ser Pro Cys Gly Asp Ala Arg Ile Phe Ser Pro His Glu Pro Ile Leu 
    450                 455                 460                 


Glu Glu Pro Ala Asp Arg His Pro Asn Arg Lys Ala Arg Gly Gln Leu 
465                 470                 475                 480 


Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro Val Arg Ser Asn 
                485                 490                 495     


Ala Ser Ile Gln Thr Trp Asp Gly Val Leu Gln Gly Glu Arg Leu Leu 
            500                 505                 510         


Thr Met Ser Cys Ser Asp Lys Ile Ala Arg Trp Asn Val Val Gly Ile 
        515                 520                 525             


Gln Gly Ser Leu Leu Ser Ile Phe Val Glu Pro Ile Tyr Phe Ser Ser 
    530                 535                 540                 


Ile Ile Leu Gly Ser Leu Tyr His Gly Asp His Leu Ser Arg Ala Met 
545                 550                 555                 560 


Tyr Gln Arg Ile Ser Asn Ile Glu Asp Leu Pro Pro Leu Tyr Thr Leu 
                565                 570                 575     


Asn Lys Pro Leu Leu Ser Gly Ile Ser Asn Ala Glu Ala Arg Gln Pro 
            580                 585                 590         


Gly Lys Ala Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Ser Ala 
        595                 600                 605             


Ile Glu Val Ile Asn Ala Thr Thr Gly Lys Asp Glu Leu Gly Arg Ala 
    610                 615                 620                 


Ser Arg Leu Cys Lys His Ala Leu Tyr Cys Arg Trp Met Arg Val His 
625                 630                 635                 640 


Gly Lys Val Pro Ser His Leu Leu Arg Ser Lys Ile Thr Lys Pro Asn 
                645                 650                 655     


Val Tyr His Glu Ser Lys Leu Ala Ala Lys Glu Tyr Gln Ala Ala Lys 
            660                 665                 670         


Val His 
        


<210>  5
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Gly Gly Ser Ser Cys Ser Gln Thr Pro Ser Arg Ala Ile Pro 
1               5                   10                  15      


Ala Thr Arg Arg Val Val Leu Gly Asp Gly Val Gln Leu Pro Pro Gly 
            20                  25                  30          


Asp Tyr Ser Thr Thr Pro Gly Gly Thr Leu Phe Ser Thr Thr Pro Gly 
        35                  40                  45              


Gly Thr Arg Ile Ile Tyr Asp Arg Lys Phe Leu Met Glu Cys Arg Asn 
    50                  55                  60                  


Ser Pro Val Thr Lys Thr Pro Pro Arg Asp Leu Pro Thr Ile Pro Gly 
65                  70                  75                  80  


Val Thr Ser Pro Ser Ser Asp Glu Pro Pro Met Glu Ala Ser Gln Ser 
                85                  90                  95      


His Leu Arg Asn Ser Pro Glu Asp Lys Arg Ala Gly Gly Glu Glu Ser 
            100                 105                 110         


Gln Phe Glu Met Asp Ile 
        115             


<210>  6
<211>  877
<212>  DNA
<213>  Homo sapiens

<400>  6
ggggcgaggc ggagcgaggc tggaggcgcg ggagggcagc gagaggttcg cgggtgcagc       60

gcacaggaga ccatgtccgg gggcagcagc tgcagccaga ccccaagccg ggccatcccc      120

gccactcgcc gggtggtgct cggcgacggc gtgcagctcc cgcccgggga ctacagcacg      180

acccccggcg gcacgctctt cagcaccacc ccgggaggta ccaggatcat ctatgaccgg      240

aaattcctga tggagtgtcg gaactcacct gtgaccaaaa cacccccaag ggatctgccc      300

accattccgg gggtcaccag cccttccagt gatgagcccc ccatggaagc cagccagagc      360

cacctgcgca atagcccaga agataagcgg gcgggcggtg aagagtcaca gtttgagatg      420

gacatttaaa gcaccagcca tcgtgtggag cactaccaag gggcccctca gggccttcct      480

gggaggagtc ccaccagcca ggccttatga aagtgatcat actgggcagg cgttggcgtg      540

gggtcggaca ccccagccct ttctccctca ctcagggcac ctgccccctc ctcttcgtga      600

acaccagcag atacctcctt gtgcctccac tgatgcagga gctgccaccc caaggggagt      660

gacccctgcc agcacaccct gcagccaagg gccaggaagt ggacaagaac gaacccttcc      720

ttccgaatga tcagcagttc cagcccctcg ctgctggggg cgcaaccacc ccttccttag      780

gttgatgtgc ttgggaaagc tccctccccc tccttcccca agagaggaaa taaaagccac      840

cttcgcccta gggccaagaa aaaaaaaaaa aaaaaaa                               877


<210>  7
<211>  632
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Glu Leu Val Val Glu Val Arg Gly Ser Asn Gly Ala Phe Tyr 
1               5                   10                  15      


Lys Ala Phe Val Lys Asp Val His Glu Asp Ser Ile Thr Val Ala Phe 
            20                  25                  30          


Glu Asn Asn Trp Gln Pro Asp Arg Gln Ile Pro Phe His Asp Val Arg 
        35                  40                  45              


Phe Pro Pro Pro Val Gly Tyr Asn Lys Asp Ile Asn Glu Ser Asp Glu 
    50                  55                  60                  


Val Glu Val Tyr Ser Arg Ala Asn Glu Lys Glu Pro Cys Cys Trp Trp 
65                  70                  75                  80  


Leu Ala Lys Val Arg Met Ile Lys Gly Glu Phe Tyr Val Ile Glu Tyr 
                85                  90                  95      


Ala Ala Cys Asp Ala Thr Tyr Asn Glu Ile Val Thr Ile Glu Arg Leu 
            100                 105                 110         


Arg Ser Val Asn Pro Asn Lys Pro Ala Thr Lys Asp Thr Phe His Lys 
        115                 120                 125             


Ile Lys Leu Asp Val Pro Glu Asp Leu Arg Gln Met Cys Ala Lys Glu 
    130                 135                 140                 


Ala Ala His Lys Asp Phe Lys Lys Ala Val Gly Ala Phe Ser Val Thr 
145                 150                 155                 160 


Tyr Asp Pro Glu Asn Tyr Gln Leu Val Ile Leu Ser Ile Asn Glu Val 
                165                 170                 175     


Thr Ser Lys Arg Ala His Met Leu Ile Asp Met His Phe Arg Ser Leu 
            180                 185                 190         


Arg Thr Lys Leu Ser Leu Ile Met Arg Asn Glu Glu Ala Ser Lys Gln 
        195                 200                 205             


Leu Glu Ser Ser Arg Gln Leu Ala Ser Arg Phe His Glu Gln Phe Ile 
    210                 215                 220                 


Val Arg Glu Asp Leu Met Gly Leu Ala Ile Gly Thr His Gly Ala Asn 
225                 230                 235                 240 


Ile Gln Gln Ala Arg Lys Val Pro Gly Val Thr Ala Ile Asp Leu Asp 
                245                 250                 255     


Glu Asp Thr Cys Thr Phe His Ile Tyr Gly Glu Asp Gln Asp Ala Val 
            260                 265                 270         


Lys Lys Ala Arg Ser Phe Leu Glu Phe Ala Glu Asp Val Ile Gln Val 
        275                 280                 285             


Pro Arg Asn Leu Val Gly Lys Val Ile Gly Lys Asn Gly Lys Leu Ile 
    290                 295                 300                 


Gln Glu Ile Val Asp Lys Ser Gly Val Val Arg Val Arg Ile Glu Ala 
305                 310                 315                 320 


Glu Asn Glu Lys Asn Val Pro Gln Glu Glu Glu Ile Met Pro Pro Asn 
                325                 330                 335     


Ser Leu Pro Ser Asn Asn Ser Arg Val Gly Pro Asn Ala Pro Glu Glu 
            340                 345                 350         


Lys Lys His Leu Asp Ile Lys Glu Asn Ser Thr His Phe Ser Gln Pro 
        355                 360                 365             


Asn Ser Thr Lys Val Gln Arg Val Leu Val Ala Ser Ser Val Val Ala 
    370                 375                 380                 


Gly Glu Ser Gln Lys Pro Glu Leu Lys Ala Trp Gln Gly Met Val Pro 
385                 390                 395                 400 


Phe Val Phe Val Gly Thr Lys Asp Ser Ile Ala Asn Ala Thr Val Leu 
                405                 410                 415     


Leu Asp Tyr His Leu Asn Tyr Leu Lys Glu Val Asp Gln Leu Arg Leu 
            420                 425                 430         


Glu Arg Leu Gln Ile Asp Glu Gln Leu Arg Gln Ile Gly Ala Ser Ser 
        435                 440                 445             


Arg Pro Pro Pro Asn Arg Thr Asp Lys Glu Lys Ser Tyr Val Thr Asp 
    450                 455                 460                 


Asp Gly Gln Gly Met Gly Arg Gly Ser Arg Pro Tyr Arg Asn Arg Gly 
465                 470                 475                 480 


His Gly Arg Arg Gly Pro Gly Tyr Thr Ser Gly Thr Asn Ser Glu Ala 
                485                 490                 495     


Ser Asn Ala Ser Glu Thr Glu Ser Asp His Arg Asp Glu Leu Ser Asp 
            500                 505                 510         


Trp Ser Leu Ala Pro Thr Glu Glu Glu Arg Glu Ser Phe Leu Arg Arg 
        515                 520                 525             


Gly Asp Gly Arg Arg Arg Gly Gly Gly Gly Arg Gly Gln Gly Gly Arg 
    530                 535                 540                 


Gly Arg Gly Gly Gly Phe Lys Gly Asn Asp Asp His Ser Arg Thr Asp 
545                 550                 555                 560 


Asn Arg Pro Arg Asn Pro Arg Glu Ala Lys Gly Arg Thr Thr Asp Gly 
                565                 570                 575     


Ser Leu Gln Ile Arg Val Asp Cys Asn Asn Glu Arg Ser Val His Thr 
            580                 585                 590         


Lys Thr Leu Gln Asn Thr Ser Ser Glu Gly Ser Arg Leu Arg Thr Gly 
        595                 600                 605             


Lys Asp Arg Asn Gln Lys Lys Glu Lys Pro Asp Ser Val Asp Gly Gln 
    610                 615                 620                 


Gln Pro Leu Val Asn Gly Val Pro 
625                 630         


<210>  8
<211>  4828
<212>  DNA
<213>  Homo sapiens

<400>  8
actttgaagt ggtcatcaaa gagatcagtt agaagaactg atctgcagtg tgtgacagac       60

caggaaagtg atatccagag gattgccacc atgaagttgt catttttagt ggagaggaag      120

caggagacca gaaagtgacc aaggatctgt ccatttagtt ccaggagata tgactgccag      180

agtggtatcc ttagtgggct gaatgttcag tggtcttact ttagtgacca agcaacaaga      240

cagtagggca tggtcagtaa ctttcagtca atttttgctt actaggataa agcaaaaata      300

agcttataca tttttagata cattttttgt aacttgctga gtacccaagg aaagtgtgct      360

tgtatttatg ggcgtctatt ttcagagcac taattattgc tgaattagaa cagaaatata      420

ggaaaactga tttttacaag gagcttcaaa gcaatctcag gtagtttctg attatgtatc      480

tctgcctacc tcggggtaca tagacagggt tacaatttgg ttgaggatat atgacatgtg      540

gtttttaaag acacctaggg gcattttaag aaaatttcct cgatatctga aaatctgtag      600

atttcaaaat tatgttaatc atgaaatatt ctgtgttgta atttttgtgt aggtgtattc      660

cagagcaaat gaaaaagagc cttgctgttg gtggttagct aaagtgagga tgataaaggg      720

tgaggtagga aaatgcctat ttaaattttt ttcttatatt gtttcctttt tttaaaccca      780

ggttgtacat tcccgtgtgg atttctattt tgaagtaata tctaattttg agtaatttaa      840

ttaaaatgtt ttcactatgt gttcagtatg tttctgttgg tcataaattt tttcacatag      900

attatttatt ttaaaataac tgaataggga gaacttctta ttcttacttt aaaaattgtg      960

attagaagtg acttttattt atttctcagt tttatgtgat agaatatgca gcatgtgatg     1020

caacttacaa tgaaattgtc acaattgaac gtctaagatc tgttaatccc aacaaacctg     1080

ccacaaaaga tactttccat aagatcaagc tggatgtgcc agaagactta cggcaaatgt     1140

gtgccaaaga ggcggcacat aaggatttta aaaaggcagt tggtgccttt tctgtaactt     1200

atgatccaga aaattatcag cttgtcattt tgtccatcaa tgaagtcacc tcaaagcgag     1260

cacatatgct gattgacatg cactttcgga gtctgcgcac taagttgtct ctgataatga     1320

gaaatgaaga agctagtaag cagctggaga gttcaaggca gcttgcctcg agatttcatg     1380

aacagtttat cgtaagagaa gatctgatgg gtctagctat tggtactcat ggtgctaata     1440

ttcagcaagc tagaaaagta cctggggtca ctgctattga tctagatgaa gatacctgca     1500

catttcatat ttatggagag gatcaggatg cagtgaaaaa agctagaagc tttctcgaat     1560

ttgctgaaga tgtaatacaa gttccaagga acttagtagg caaagtaata ggaaaaaatg     1620

gaaagctgat tcaggagatt gtggacaagt caggagttgt gagggtgagg attgaggctg     1680

aaaatgagaa aaatgttcca caagaagagg aaattatgcc accaaattcc cttccttcca     1740

ataattcaag ggttggacct aatgccccag aagaaaaaaa acatttagat ataaaggaaa     1800

acagcaccca tttttctcaa cctaacagta caaaagtcca gaggggtatg gtaccatttg     1860

tttttgtggg aacaaaggac agcatcgcta atgccactgt tcttttggat tatcacctga     1920

actatttaaa ggaagtagac cagttgcgtt tggagagatt acaaattgat gagcagttgc     1980

gacagattgg agctagttct agaccaccac caaatcgtac agataaggaa aaaagctatg     2040

tgactgatga tggtcaagga atgggtcgag gtagtagacc ttacagaaat agggggcacg     2100

gcagacgcgg tcctggatat acttcaggaa ctaattctga agcatcaaat gcttctgaaa     2160

cagaatctga ccacagagac gaactcagtg attggtcatt agctccaaca gaggaagaga     2220

gggagagctt cctgcgcaga ggagacggac ggcggcgtgg agggggagga agaggacaag     2280

gaggaagagg acgtggagga ggcttcaaag gaaacgacga tcactcccga acagataatc     2340

gtccacgtaa tccaagagag gctaaaggaa gaacaacaga tggatccctt cagatcagag     2400

ttgactgcaa taatgaaagg agtgtccaca ctaaaacatt acagaatacc tccagtgaag     2460

gtagtcggct gcgcacgggt aaagatcgta accagaagaa agagaagcca gacagcgtgg     2520

atggtcagca accactcgtg aatggagtac cctaaactgc ataattctga agttatattt     2580

cctataccat ttccgtaatt cttattccat attagaaaac tttgttaggc caaagacaaa     2640

tagtaggcaa gatggcacag ggcatgaaat gaacacaaat tatgctaaga attttttatt     2700

ttttggtatt ggccataagc aacaattttc agatttgcac aaaaagatac cttaaaattt     2760

gaaacattgc ttttaaaact acttagcact tcagggcaga ttttagtttt attttctaaa     2820

gtactgagca gtgatattct ttgttaattt ggaccatttt cctgcattgg gtgatcattc     2880

accagtacat tctcagtttt tcttaatata tagcatttat ggtaatcata ttagacttct     2940

gttttcaatc tcgtatagaa gtcttcatga aatgctatgt catttcatgt cctgtgtcag     3000

tttatgtttt ggtccacttt tccagtattt tagtggaccc tgaaatgtgt gtgatgtgac     3060

atttgtcatt ttcattagca aaaaaagttg tatgatctgt gcctttttta tatcttggca     3120

ggtaggaata ttatatttgg atgcagagtt cagggaagat aagttggaaa cactaaatgt     3180

taaagatgta gcaaaccctg tcaaacatta gtactttata gaagaatgca tgctttccat     3240

atttttttcc ttacataaac atcaggttag gcagtataaa gaataggact tgtttttgtt     3300

tttgttttgt tgcactgaag tttgataaat agtgttattg agagagatgt gtaatttttc     3360

tgtatagaca ggagaagaaa gaactatctt catctgagag aggctaaaat gttttcagct     3420

aggaacaaat cttcctggtc gaaagttagt aggatatgcc tgctctttgg cctgatgacc     3480

aattttaact tagagctttt tttttttaat tttgtctgcc ccaagttttg tgaaattttt     3540

catattttaa tttcaagctt attttggaga gataggaagg tcatttccat gtatgcataa     3600

taatcctgca aagtacaggt actttgtcta agaaacattg gaagcaggtt aaatgttttg     3660

taaactttga aatatatggt ctaatgttta agcagaattg gaaaagacta agatcggtta     3720

acaaataaca actttttttt ctttttttct tttgtttttt gaagtgttgg ggtttggttt     3780

tgttttttga gtcttttttt ttaagtgaaa tttattgagg aaaaatatgt gaaggacctt     3840

cactctaaga tgttatattt ttcttaaaaa gtaactccta gtaggggtac cactgaatct     3900

gtacagagcc gtaaaaactg aagttctgcc tctgatgtat tttgtgagtt tgtttctttg     3960

aattttcatt ttacagttac ttttccttgc atacaaacaa gcatataaaa tggcaacaaa     4020

ctgcacatga tttcacaaat attaaaaagt cttttaaaaa gtattgccaa acattaatgt     4080

tgatttctag ttatttattc tgggaatgta tagtattgaa aacagaaatt ggtaccttgc     4140

acacatcatc tgtaagctgt ttggttttaa aatactgtag ataattaacc aaggtagaat     4200

gaccttgtaa tgtaactgct cttgggcaat attctctgta catattagcg acaacagatt     4260

ggattttatg ttgacatttg tttggttata gtgcaatata ttttgtatgc aagcagtttc     4320

aataaagttt gatcttcctc tgctaaattg atgttgatgc aatccttaca aatgattgct     4380

tttaaaattt taagctagga aaagaaatct atagaaagtg ttctgttaca aaatgtaact     4440

gttaccattg gaaatttcac gtcataggaa gttagccttt atctaccaac tttcaagaac     4500

ttgtttaata aagcgaaaaa ctcaaccaaa tggtacaaaa ccacagtgta ccattaaaat     4560

atgcactaag tctctttttt acaaaggctg tattcagcaa ggcgctaact tgcttaaatg     4620

tgaattacta acttctaaaa ctgtactttg attcacatgt tttcaaatgg agttggagtt     4680

cattcatatt acaatatttg tgtgctaaac gtgtatgttt ttcagttcaa agtcatgatg     4740

tttttaaaat cttattaaag tttcaaaaat ctgaagattg tttatctaga tgtaaatttt     4800

tattaaaaag ttgcacttat gaaaaagc                                        4828


<210>  9
<211>  526
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ser Asn Asp Tyr Thr Gln Gln Ala Thr Gln Ser Tyr Gly Ala 
1               5                   10                  15      


Tyr Pro Thr Gln Pro Gly Gln Gly Tyr Ser Gln Gln Ser Ser Gln Pro 
            20                  25                  30          


Tyr Gly Gln Gln Ser Tyr Ser Gly Tyr Ser Gln Ser Thr Asp Thr Ser 
        35                  40                  45              


Gly Tyr Gly Gln Ser Ser Tyr Ser Ser Tyr Gly Gln Ser Gln Asn Thr 
    50                  55                  60                  


Gly Tyr Gly Thr Gln Ser Thr Pro Gln Gly Tyr Gly Ser Thr Gly Gly 
65                  70                  75                  80  


Tyr Gly Ser Ser Gln Ser Ser Gln Ser Ser Tyr Gly Gln Gln Ser Ser 
                85                  90                  95      


Tyr Pro Gly Tyr Gly Gln Gln Pro Ala Pro Ser Ser Thr Ser Gly Ser 
            100                 105                 110         


Tyr Gly Ser Ser Ser Gln Ser Ser Ser Tyr Gly Gln Pro Gln Ser Gly 
        115                 120                 125             


Ser Tyr Ser Gln Gln Pro Ser Tyr Gly Gly Gln Gln Gln Ser Tyr Gly 
    130                 135                 140                 


Gln Gln Gln Ser Tyr Asn Pro Pro Gln Gly Tyr Gly Gln Gln Asn Gln 
145                 150                 155                 160 


Tyr Asn Ser Ser Ser Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Asn 
                165                 170                 175     


Tyr Gly Gln Asp Gln Ser Ser Met Ser Ser Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Tyr Gly Asn Gln Asp Gln Ser Gly Gly Gly Gly Ser Gly Gly Tyr 
        195                 200                 205             


Gly Gln Gln Asp Arg Gly Gly Arg Gly Arg Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Tyr Asn Arg Ser Ser Gly Gly Tyr Glu 
225                 230                 235                 240 


Pro Arg Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Gly Met Gly Gly 
                245                 250                 255     


Ser Asp Arg Gly Gly Phe Asn Lys Phe Gly Gly Pro Arg Asp Gln Gly 
            260                 265                 270         


Ser Arg His Asp Ser Glu Gln Asp Asn Ser Asp Asn Asn Thr Ile Phe 
        275                 280                 285             


Val Gln Gly Leu Gly Glu Asn Val Thr Ile Glu Ser Val Ala Asp Tyr 
    290                 295                 300                 


Phe Lys Gln Ile Gly Ile Ile Lys Thr Asn Lys Lys Thr Gly Gln Pro 
305                 310                 315                 320 


Met Ile Asn Leu Tyr Thr Asp Arg Glu Thr Gly Lys Leu Lys Gly Glu 
                325                 330                 335     


Ala Thr Val Ser Phe Asp Asp Pro Pro Ser Ala Lys Ala Ala Ile Asp 
            340                 345                 350         


Trp Phe Asp Gly Lys Glu Phe Ser Gly Asn Pro Ile Lys Val Ser Phe 
        355                 360                 365             


Ala Thr Arg Arg Ala Asp Phe Asn Arg Gly Gly Gly Asn Gly Arg Gly 
    370                 375                 380                 


Gly Arg Gly Arg Gly Gly Pro Met Gly Arg Gly Gly Tyr Gly Gly Gly 
385                 390                 395                 400 


Gly Ser Gly Gly Gly Gly Arg Gly Gly Phe Pro Ser Gly Gly Gly Gly 
                405                 410                 415     


Gly Gly Gly Gln Gln Arg Ala Gly Asp Trp Lys Cys Pro Asn Pro Thr 
            420                 425                 430         


Cys Glu Asn Met Asn Phe Ser Trp Arg Asn Glu Cys Asn Gln Cys Lys 
        435                 440                 445             


Ala Pro Lys Pro Asp Gly Pro Gly Gly Gly Pro Gly Gly Ser His Met 
    450                 455                 460                 


Gly Gly Asn Tyr Gly Asp Asp Arg Arg Gly Gly Arg Gly Gly Tyr Asp 
465                 470                 475                 480 


Arg Gly Gly Tyr Arg Gly Arg Gly Gly Asp Arg Gly Gly Phe Arg Gly 
                485                 490                 495     


Gly Arg Gly Gly Gly Asp Arg Gly Gly Phe Gly Pro Gly Lys Met Asp 
            500                 505                 510         


Ser Arg Gly Glu His Arg Gln Asp Arg Arg Glu Arg Pro Tyr 
        515                 520                 525     


<210>  10
<211>  5119
<212>  DNA
<213>  Homo sapiens

<400>  10
acttaagctt cgacgcagga ggcggggctg ctcagtcctc caggcgtcgg tactcagcgg       60

tgttggaact tcgttgcttg cttgcctgtg cgcgcgtgcg cggacatggc ctcaaacgat      120

tatacccaac aagcaaccca aagctatggg gcctacccca cccagcccgg gcagggctat      180

tcccagcaga gcagtcagcc ctacggacag cagagttaca gtggttatag ccagtccacg      240

gacacttcag gctatggcca gagcagctat tcttcttatg gccagagcca gaacacaggc      300

tatggaactc agtcaactcc ccagggatat ggctcgactg gcggctatgg cagtagccag      360

agctcccaat cgtcttacgg gcagcagtcc tcctaccctg gctatggcca gcagccagct      420

cccagcagca cctcgggaag ttacggtagc agttctcaga gcagcagcta tgggcagccc      480

cagagtggga gctacagcca gcagcctagc tatggtggac agcagcaaag ctatggacag      540

cagcaaagct ataatccccc tcagggctat ggacagcaga accagtacaa cagcagcagt      600

ggtggtggag gtggaggtgg aggtggaggt aactatggcc aagatcaatc ctccatgagt      660

agtggtggtg gcagtggtgg cggttatggc aatcaagacc agagtggtgg aggtggcagc      720

ggtggctatg gacagcagga ccgtggaggc cgcggcaggg gtggcagtgg tggcggcggc      780

ggcggcggcg gtggtggtta caaccgcagc agtggtggct atgaacccag aggtcgtgga      840

ggtggccgtg gaggcagagg tggcatgggc ggaagtgacc gtggtggctt caataaattt      900

ggtggccctc gggaccaagg atcacgtcat gactccgaac aggataattc agacaacaac      960

accatctttg tgcaaggcct gggtgagaat gttacaattg agtctgtggc tgattacttc     1020

aagcagattg gtattattaa gacaaacaag aaaacgggac agcccatgat taatttgtac     1080

acagacaggg aaactggcaa gctgaaggga gaggcaacgg tctcttttga tgacccacct     1140

tcagctaaag cagctattga ctggtttgat ggtaaagaat tctccggaaa tcctatcaag     1200

gtctcatttg ctactcgccg ggcagacttt aatcggggtg gtggcaatgg tcgtggaggc     1260

cgagggcgag gaggacccat gggccgtgga ggctatggag gtggtggcag tggtggtggt     1320

ggccgaggag gatttcccag tggaggtggt ggcggtggag gacagcagcg agctggtgac     1380

tggaagtgtc ctaatcccac ctgtgagaat atgaacttct cttggaggaa tgaatgcaac     1440

cagtgtaagg cccctaaacc agatggccca ggagggggac caggtggctc tcacatgggg     1500

ggtaactacg gggatgatcg tcgtggtggc agaggaggct atgatcgagg cggctaccgg     1560

ggccgcggcg gggaccgtgg aggcttccga gggggccggg gtggtgggga cagaggtggc     1620

tttggccctg gcaagatgga ttccaggggt gagcacagac aggatcgcag ggagaggccg     1680

tattaattag cctggctccc caggttctgg aacagctttt tgtcctgtac ccagtgttac     1740

cctcgttatt ttgtaacctt ccaattcctg atcacccaag ggtttttttg tgtcggacta     1800

tgtaattgta actatacctc tggttcccat taaaagtgac cattttagtt aaattttgtt     1860

cctcttcccc cttttcactt tcctggaaga tcgatgtccc gatcaggaag gtagagagtt     1920

ttcctgttca gattaccctg cccagcagga actggaatac agtgttcggg gagaaggcca     1980

aatgatatcc ttgagagcag agattaaact tttctgtcat ggggaaagtt ggtgtataaa     2040

tgagaaatga agaacatggg atgtcatgag tgttggccta aatttgccca gctatgggga     2100

atttttcctt taccacattt atttgcatac tggtcttagt ttatttgcag cagtttatcc     2160

ctttttaaga actctttgat cttttggccc ttttaatggt gaggctcaaa caaactacat     2220

ttaaatgggg cagtattcag atttgaccat ggtggagagc gcttagccac tctgggtctt     2280

tcacaggaag gagagtaact gagtgctgca ggagtttgtg gagtggagtc aggatctagg     2340

aggtgagtga ctcccttcct agctgccctg gtgaacagcg cttgggtaga tacctgctat     2400

aaggagactg gtctggctgg gttactttca catcctgcct gtactcagag ggcttgaggt     2460

cattgacatt atgagatttt aggcttgatc cctttttgat tggagggtgg aaggccctcc     2520

taagggaatg ataagtgata agagggggaa ggggttgcag ccaatgagtt aaaaccttag     2580

agcagtgctc ctcagcctct taccatgtgg ttgtaaactt gcacgtacct gccaaccagt     2640

tatttagcat gctttttatt ttagttacac agagcgtaac attaacccaa gagcagaaag     2700

gttttattta cagggttttc gaacttggtt tgtaagacag ctgccatcac aagcatagct     2760

tacaaatgtg ctggggaccc ctaattggga agtgctttcc tctcaaattt ttatttttta     2820

tttttagaga cagagtcttg ctctgtcatc caggctggag tgcagtggcg tgatctcggc     2880

tcactgtagc ctctgcctcc tgagtttaag cgattctcct gcctcaggag aatcccagct     2940

tctgagtagc tgagactaca ggcgtgggcc accatgccca cctagttttt gcatttttag     3000

tggaggtgtg gtttcactgt gttggccagg ctggtctctt aactcctgac ctcaggtgat     3060

ccacctgcct tggcctccca aagtgctgga attacaggca tgagccgctg catctggcca     3120

tcctctcaaa ttttcaagtg ttccacaagt atgttctcta ctgaagagtt gctgcatcct     3180

tgaatcttgg gtgatttgag gcacagaaac tatgacttta ttttttgaga tggagttttg     3240

ctcttgttgc ccaggctgga gtgcaatggc acgtttttcg gcttaccgca actgccgcct     3300

cctgggttca agcgatagct gggattacag gcatgcgcca ccatgcccag ctaatttatt     3360

tgtattttta gtagagacgg ggtttctcca tgttggtcag gctggtctcg aactcccgac     3420

ctcaggtgat gtgcacacct cagcctccca ataaaccatg acttttaaga ggaatagcag     3480

gtttacttcc cctgccagca ttggggtgct ctctaagcaa cagtaggcgg agagtggtct     3540

ggcgtattaa aaacaaagga tcgtcaagtg ggccttccca ggcattgctt tgacttagta     3600

catgtagagg atgtggcagt tctctccgtc cctgccactg ctggtttctt tgttaaatgt     3660

ttagttgaaa tggcctgata cgatatttga gtagttcact gttggtgctt tgcctagcag     3720

gattctaatc ttgctttggt tgtggtcccc tgatgccctc ctgttaggag tggaggaggt     3780

cgaagctcct tgtaagatat gattactggg accattagtg tcaagttcct gtgtccttca     3840

aatggcatat gtgattggcc ttgaccttaa aaggaaatag ggtcccaggt gactgtttag     3900

tgggtaggtc cagtttgggg ggatcttcca ggagaatgga tagagacacc tagcagcaga     3960

gagaacattg gtgcctctca agccaacctc ccacctcagc ctcccaagta gctgggacta     4020

caggtgcttc ctcgctacca cacctgggta attttttttt taattacttt ttttttttta     4080

agaaacaggg tttcactggg ttgcccaggc tggtcttgaa ctggcctcaa gtgacctgcc     4140

tgcctcagcc tcccaaagtg ctgggatcac aggtgtgacc cactgcgttt ggccagaata     4200

ctctattctt actgaatgat tgaaatctgt cttgaagcat taggtgtccc atttttgtga     4260

gttggaattg ggacaggcta agtaggaagt gaggagggtg gggagagctg tgctgtaggt     4320

ctgtttgtcc cttccttgat gtagccttca gttagccctt tcagcttttt tccccatctt     4380

gtgccgggcc ttcctgggtt tcagtacttg gatgtagggc tgcagttatg tcagtggtgg     4440

gtagattgac caggaattaa ggtctagggt ccagcccatg tgagacttga ctcactgatc     4500

tacctttagg catgtcttcc ttccagtctc atccttttta aatttttttt ttttttttga     4560

gacggtctca ctctcaccca ggctggattg cagtggtgtg atctcgacca actgcaacct     4620

ctgcctccca cccgcaagct atctgcccac ctcagcctct ggagtagctg ggacgggact     4680

acaggcacct gccaccatga ctggctaatt tttttttgta ttttttgtgg agatggggtc     4740

ttgccatgtt gctcaggctg gtctggtctc aaaactgctc tgggctcaag tgattgtccc     4800

actttggcct cccagagtgc tgggattaag gtgtgagata ctgtgtccgg ctatgaaaat     4860

tttattttta attaacttgt atatatttat ggggtacaat gtcctatttc tgtacatgta     4920

cacattgtgg aatcaaatca ggctaatata tccatcactt catatcatta gcatgaatga     4980

gaacatacaa agccactctt agaaaatttt gaaatttatg ttatttcagc ccttttatgc     5040

tggaggttgc aaatgttttg tgaataatca gaccaaaaat aaaaacaaaa aatgattgac     5100

ttcagtcatt cagtaagaa                                                  5119


<210>  11
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Glu Ala Gly Glu Glu Gln Pro Met Glu Thr Thr Gly Ala Thr 
1               5                   10                  15      


Glu Asn Gly His Glu Ala Val Pro Glu Gly Glu Ser Pro Ala Gly Ala 
            20                  25                  30          


Gly Thr Gly Ala Ala Ala Gly Ala Gly Gly Ala Thr Ala Ala Pro Pro 
        35                  40                  45              


Ser Gly Asn Gln Asn Gly Ala Glu Gly Asp Gln Ile Asn Ala Ser Lys 
    50                  55                  60                  


Asn Glu Glu Asp Ala Gly Lys Met Phe Val Gly Gly Leu Ser Trp Asp 
65                  70                  75                  80  


Thr Ser Lys Lys Asp Leu Lys Asp Tyr Phe Thr Lys Phe Gly Glu Val 
                85                  90                  95      


Val Asp Cys Thr Ile Lys Met Asp Pro Asn Thr Gly Arg Ser Arg Gly 
            100                 105                 110         


Phe Gly Phe Ile Leu Phe Lys Asp Ala Ala Ser Val Glu Lys Val Leu 
        115                 120                 125             


Asp Gln Lys Glu His Arg Leu Asp Gly Arg Val Ile Asp Pro Lys Lys 
    130                 135                 140                 


Ala Met Ala Met Lys Lys Asp Pro Val Lys Lys Ile Phe Val Gly Gly 
145                 150                 155                 160 


Leu Asn Pro Glu Ala Thr Glu Glu Lys Ile Arg Glu Tyr Phe Gly Glu 
                165                 170                 175     


Phe Gly Glu Ile Glu Ala Ile Glu Leu Pro Met Asp Pro Lys Leu Asn 
            180                 185                 190         


Lys Arg Arg Gly Phe Val Phe Ile Thr Phe Lys Glu Glu Glu Pro Val 
        195                 200                 205             


Lys Lys Val Leu Glu Lys Lys Phe His Thr Val Ser Gly Ser Lys Cys 
    210                 215                 220                 


Glu Ile Lys Val Ala Gln Pro Lys Glu Val Tyr Gln Gln Gln Gln Tyr 
225                 230                 235                 240 


Gly Ser Gly Gly Arg Gly Asn Arg Asn Arg Gly Asn Arg Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gln Ser Gln Ser Trp Asn Gln Gly Tyr 
            260                 265                 270         


Gly Asn Tyr Trp Asn Gln Gly Tyr Gly Tyr Gln Gln Gly Tyr Gly Pro 
        275                 280                 285             


Gly Tyr Gly Gly Tyr Asp Tyr Ser Pro Tyr Gly Tyr Tyr Gly Tyr Gly 
    290                 295                 300                 


Pro Gly Tyr Asp Tyr Ser Gln Gly Ser Thr Asn Tyr Gly Lys Ser Gln 
305                 310                 315                 320 


Arg Arg Gly Gly His Gln Asn Asn Tyr Lys Pro Tyr 
                325                 330         


<210>  12
<211>  1837
<212>  DNA
<213>  Homo sapiens

<400>  12
aaagggcgcc acgagtcggc attgtcaggc ggcggcaccg cgcgggacgg agcttggctg       60

ttggtcggtg ggttcccgtg cggcggcggc caaggaggag gagacacagt tggagcagct      120

ccgtgggctg actggggcga ggcctcagca gcgcgagctt gagtgcggcc gagcctgcgg      180

cgccttcccc tgcgggtggg gacgagcggg ccccgcggcg tcatcggcgg cgaggagccg      240

ccgcgcctcg gcctagcatg tcggaagcgg gcgaggagca gcccatggag acgacgggcg      300

ccaccgagaa cggacatgag gccgtccccg aaggcgagtc gccggccggg gctggcacgg      360

gcgccgcggc gggggctgga ggcgcgaccg cggcgccccc gagcgggaat cagaacggcg      420

ccgagggcga ccagatcaac gccagcaaga acgaggagga cgcgggaaaa atgttcgttg      480

gtggcctgag ctgggatact agcaaaaaag atttaaaaga ctattttact aaatttggag      540

aggtcgttga ctgtacaata aaaatggatc ccaacactgg acggtcaaga gggtttgggt      600

ttatcctgtt caaagatgca gccagtgtgg agaaggtcct agaccagaag gagcacaggc      660

tggatggccg tgtcattgac cctaaaaagg ccatggctat gaagaaggac ccggtgaaga      720

aaatcttcgt tgggggtctg aatcctgaag ccactgagga aaagatcagg gagtactttg      780

gcgagtttgg ggagattgag gccattgaat tgccaatgga tccaaagttg aacaaaagac      840

gaggttttgt gtttatcacc tttaaagaag aagaacccgt gaagaaggtt ctggagaaaa      900

agttccatac tgtcagtgga agcaagtgtg agatcaaggt ggcccagccc aaagaagtct      960

atcagcagca gcagtatggc tctgggggcc gtggaaaccg caaccgaggg aaccgaggca     1020

gcggaggtgg tggtggaggt ggaggtcaga gtcagagttg gaatcagggc tacggcaact     1080

actggaacca gggctacggc taccagcagg gctacgggcc tggctatggc ggctacgact     1140

actcgcccta tggctattac ggctacggcc ccggctacga ctacagtcag ggtagtacaa     1200

actacggcaa gagccagcga cgtggtggcc atcagaataa ctacaagcca tactgaggcg     1260

gcagcaggag cgaccaactg atcgcacaca tgctttgttt ggatatggag tgaacacaat     1320

tatgtaccaa atttaacttg gcaaactttc tattgcctgt cccatgtgca tcttatttaa     1380

aatttccccc atggaaatca ctctcctgtt gactatttcc agagctctag gtgtttaggc     1440

agcgtgtggt gtctgagagg ccatagcgcc atcatgggct gatttttatt accaggtccc     1500

ccagaagcag gtgggaggct ctgcttcctg ctgccgctct gcagcctgga cctgtggacc     1560

ctggttgtaa agagtaaatt gtatcttagg aaaccagtgt cacctttttt tcacctttta     1620

attttatatt atttgcgtca tacatttcct gtaacggaag tgttaatttt actgtacttt     1680

ttggtacctt ttgggaatct aatgtattgt aaggtatttt acacgtgtcc tgattttgcc     1740

acaacctgga tattgaagct atccaagctt ttgaaataaa atttaaaaac ccccaagcct     1800

gggtgagtgt gggataaaaa aaaaaaaaaa aaaaaaa                              1837


<210>  13
<211>  326
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Ser Asn Gly Tyr Glu Asp His Met Ala Glu Asp Cys Arg Gly Asp 
1               5                   10                  15      


Ile Gly Arg Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln Asn Met Thr 
            20                  25                  30          


Gln Asp Glu Leu Arg Ser Leu Phe Ser Ser Ile Gly Glu Val Glu Ser 
        35                  40                  45              


Ala Lys Leu Ile Arg Asp Lys Val Ala Gly His Ser Leu Gly Tyr Gly 
    50                  55                  60                  


Phe Val Asn Tyr Val Thr Ala Lys Asp Ala Glu Arg Ala Ile Asn Thr 
65                  70                  75                  80  


Leu Asn Gly Leu Arg Leu Gln Ser Lys Thr Ile Lys Val Ser Tyr Ala 
                85                  90                  95      


Arg Pro Ser Ser Glu Val Ile Lys Asp Ala Asn Leu Tyr Ile Ser Gly 
            100                 105                 110         


Leu Pro Arg Thr Met Thr Gln Lys Asp Val Glu Asp Met Phe Ser Arg 
        115                 120                 125             


Phe Gly Arg Ile Ile Asn Ser Arg Val Leu Val Asp Gln Thr Thr Gly 
    130                 135                 140                 


Leu Ser Arg Gly Val Ala Phe Ile Arg Phe Asp Lys Arg Ser Glu Ala 
145                 150                 155                 160 


Glu Glu Ala Ile Thr Ser Phe Asn Gly His Lys Pro Pro Gly Ser Ser 
                165                 170                 175     


Glu Pro Ile Thr Val Lys Phe Ala Ala Asn Pro Asn Gln Asn Lys Asn 
            180                 185                 190         


Val Ala Leu Leu Ser Gln Leu Tyr His Ser Pro Ala Arg Arg Phe Gly 
        195                 200                 205             


Gly Pro Val His His Gln Ala Gln Arg Phe Arg Phe Ser Pro Met Gly 
    210                 215                 220                 


Val Asp His Met Ser Gly Leu Ser Gly Val Asn Val Pro Gly Asn Ala 
225                 230                 235                 240 


Ser Ser Gly Trp Cys Ile Phe Ile Tyr Asn Leu Gly Gln Asp Ala Asp 
                245                 250                 255     


Glu Gly Ile Leu Trp Gln Met Phe Gly Pro Phe Gly Ala Val Thr Asn 
            260                 265                 270         


Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys Gly Phe Gly 
        275                 280                 285             


Phe Val Thr Met Thr Asn Tyr Glu Glu Ala Ala Met Ala Ile Ala Ser 
    290                 295                 300                 


Leu Asn Gly Tyr Arg Leu Gly Asp Lys Ile Leu Gln Val Ser Phe Lys 
305                 310                 315                 320 


Thr Asn Lys Ser His Lys 
                325     


<210>  14
<211>  6075
<212>  DNA
<213>  Homo sapiens

<400>  14
ggtcgtgcgc gctgaggagg agccgctgcc gccgtcgccg tcgccgccac cgccgccacc       60

gctaccgagg ccgagcggag ccgttagcgc cgcgccgccg ccgcctcccg cccgccccgg      120

agcagccccg ggcccgcccg cccgcatcca gatttttgaa aaatacaatg tctaatggtt      180

atgaagacca catggccgaa gactgcaggg gtgacatcgg gagaacgaat ttgatcgtca      240

actacctccc tcagaacatg acccaggatg agttacgaag cctgttcagc agcattggtg      300

aagttgaatc tgcaaaactt attcgggata aagtagcagg acacagcttg ggctatggct      360

ttgtgaacta cgtgaccgcg aaggatgcag agagagcgat caacacgctg aacggcttga      420

ggctccagtc aaaaaccatt aaggtgtcgt atgctcgccc gagctcagag gtgatcaaag      480

acgccaactt gtacatcagc gggctcccgc ggaccatgac ccagaaggac gtagaagaca      540

tgttctctcg gtttgggcgg atcatcaact cgcgggtcct cgtggatcag actacaggtt      600

tgtccagagg ggttgcgttt atccggtttg acaaacggtc ggaggcagaa gaggcaatta      660

ccagtttcaa tggtcataaa cccccaggtt cctctgagcc catcacagtg aagtttgcag      720

ccaaccccaa ccagaacaaa aacgtggcac tcctctcgca gctgtaccac tcgccagcgc      780

gacggttcgg aggccccgtt caccaccagg cgcagagatt caggttctcc cccatgggcg      840

tcgatcacat gagcgggctc tctggcgtca acgtgccagg aaacgcctcc tccggctggt      900

gcattttcat ctacaacctg gggcaggatg ccgacgaggg gatcctctgg cagatgtttg      960

ggccgtttgg tgccgtcacc aatgtgaaag tgatccgcga cttcaacacc aacaagtgca     1020

aagggtttgg ctttgtgacc atgacaaact atgaagaagc cgcgatggcc atagccagcc     1080

tgaacggcta ccgcctgggg gacaaaatct tacaggtttc cttcaaaacc aacaagtccc     1140

acaaataact cgctcatgct tttttttgta cggaatagat aattaagagt gaaggagttg     1200

aaacttttct tgttagtgta caactcattt tgcgccaatt ttcacaagtg tttgtctttg     1260

tctgaatgag aagtgagaag gtttttatac tctgggatgc aaccgacatg ttcaaatgtt     1320

tgaaatccca caatgttaga ccaatcttaa gtttcgtaag ttatttcctt taagatatat     1380

attaaacaga aatctaagta gaactgcatt gactaaccag tccctctgga tggtggtgaa     1440

cctgaagcat gctttaacct ctaagactgt ctaacacgcg tttcattcaa tgtctccaca     1500

gactgggtag caaaaaaatc accttttagt tttagttttt aatctaaaga tgttagacag     1560

atgctgagtg tgcgttttct caaccgcttc aacattgtaa gcgatgtatg ctttggttga     1620

caggaagttc cttttccagg caggtcccgt tgccacctcc tgctcactca gtcccgggct     1680

ctgccgagtg gtcctgggaa tggcggcggg cccgtccagc gtgggccacc actggggccg     1740

ggggccacgg gctgcatgct gggcgggccc tccagagaag gacacaaacg tgtttcgtaa     1800

gcccaggcac caatgggaat ggaccaaaga gtttcaggga aactccagta tattccagag     1860

tcagatctaa gctccaggca cgcctgaaga tgtgttgcta ctctgacatc ccgagtttct     1920

gtccacacat tgcatgcaca gcgccccaca cattggatac tgttgttcac gataatttct     1980

cccgttttcc agagcattta acatagcttg gaggcgtaaa atggctctgt attttaataa     2040

cacagaaaca tttgagcatt gtatttctcg catcccttct cgtgagcgct tagacctttt     2100

tctattttag tcggattttg ttttggaatt ttgcttttgt atgaacactc agcagaaaag     2160

tacttacttc ttgccagtta tctattaacc aaaacctttg atttgtagtt ttaaagatta     2220

accctcaaag ttctcttcat aactgccttg acattttggg ttgttctgtt ctgttaattt     2280

tcttttgctt ttttgtgttt tttgtttgtt tttacttttg catttaagac cattaaattt     2340

gattttgttt tgctcgaatt ttgttttgtt ttttatttta ccttttcttt ctttttggct     2400

agggaaggtg caggtggccc agcattcagg gaggagtcgt aagatcttaa gaaaccaatc     2460

cttgcctcaa gcaaaagcat ttctgaatct gtgacgcaag aatgtgcagt tacaggctgg     2520

tggcttttaa accaggagcc cggaggaagg gtgaaagaga aagcctgtga aataggcagg     2580

gccagatcac ccaaaactcc tcaggactgg gatctggcgt ttataaataa ctagtttaca     2640

gagagaatca caaacaggat aacttagtac cagcagtttt taaccttgac gtgagactaa     2700

aacgtgaccg taggctgttt tttagttatt gctctcatga gatgatggct gtatttatct     2760

gtttatttat acctatttat gtatttattt attgaagtgt gaaattgagc aataggcagg     2820

caccaccgtc cccagagcag gtcagcgtct cgagaggccc ctggacaatt gaggatgccc     2880

atcccctccc ctttccctga tcttttactg aggggctgtg tgcgcgatcc ttgcaaattg     2940

atgatgttgc catccgtacc caggctgtgt ctcataaaag tcggcctggt gccagagagg     3000

acctcctttc tcccacagaa tcccagatcc tcaggaaaag ccaaaaccga ggcccattgc     3060

ccggattcga cacaaaagag ggtccctgct ctgttgcccg agagcagtct gcatcctggg     3120

accagaatgc tttcctggaa aaagaagcct ttcaggtttc cctgggccag catcttctga     3180

tggaaggtgg gagccaacac ccttctgatg gaaggtggga gccaacaccc ttctgatgga     3240

aggtgggagc caacaccctt ctgatggaag gtgggagcca acacccttct gatggaaggt     3300

gggagccaac acccttctga tggaaggcgg gattcccgct tctgaaactc cccctggagt     3360

ctcactccca cacatgccca tagctagcat tcaacagaga actctgtctt aagcttcaac     3420

tgtgaaaatg atgacgggct tgtagcacct cagcttcttt cctcgccccc ttttatctga     3480

atcctatcaa ttattctgat gctgggacag gtgagaagaa actgtgaagt atatgagcct     3540

ttgaaagttc cctgaagttt ctcagttcag gaacattctc attgtatgtg gtctccgctg     3600

tttgaacagc cttctagcta aaaaattcca aagcctttat ttgggagtct tagcttgcaa     3660

gcttgtggaa ggatttagct taacaactgt cactcctgaa aagcaatctc tgttccatca     3720

aggttctagt tgctggccct gtgtcctcaa agttcattac atcttatcaa ggcctgtttg     3780

caaaggggag atcccttttc ttaaaaaagg ctcaacccaa aagaaaccat ttcttaaaaa     3840

attttacata gatcagttgt atttctattt agcaaaaatg agtgctctgc ttttatttgg     3900

gaatttcgat gaaaaagcgt tcagagtaga taatgttcat ttatcaaaaa tctggtttgg     3960

gaaataccaa agaggctttg attgaattcc cttttgaccc gtgtgtaact tcctctggta     4020

gttagacccc aggcagctcc gaatttgtga acctgcttcc tgatgaattc tcccttgttc     4080

ccccttggct ctgccattat ttcgttttca gtgtaatttg ccaagccgca gttttctgtg     4140

ctggctgtgc ctctagtcgc agctctgtga ctgattccct cccgggtgct gagtcccctc     4200

cccggccacc atcctgcgtg aatatcctga aattcatggg cttcctcggg ggcccgcccg     4260

caggtggtgc tgggtgggtt ccgccacctt ctcctggaag gtgagccttt tcctggccaa     4320

gggcagctgc cttaacctct gagagtctgc gcttggcctt agtcctggag acccagcctc     4380

cagggactga accgtgctgc tgttgggagc caagaccggc cctttggagc cggcagccca     4440

ggggtccctg ctggatcaga gaaatagaag cacccgaaga cggttagtgg caattccttg     4500

acccggtttg cttccaaatg aaggccattt gtccaccagg cattgaaaag acatgactta     4560

cccagtccgg catcggactt gaaaaatcga aattgacatc actcagctgt tacatttcac     4620

atccgattca gccccctttt atttccatgt gcttttcgca gccttcctgt gttggatgaa     4680

agagaataag aattcagctg acaggaggcc tctatcctgt ccctccaccc caccctccac     4740

ctcaatcccc tcccatcttc cccagaccta cctcacctac taggacctga ggcagctcct     4800

tagcagagac ccctggggtt tagctgactc tgggggtcag gggttcctgt ccccaaactt     4860

cgcaagacag ccctgaagtc acaagtgctt tcttttaagt ggcattggca attggcgtgt     4920

aatgatggca gtagaatctg aatctcggat cccaggcagg gttcacattt ccaaaccttt     4980

ttgatttccc ctgacctcta atggctggat cctatttttc tacaaccttt cagtgacatc     5040

gttcaggttt ctttcttggc catttaaaaa aacaaatttt ttttttctca cttgtaagtc     5100

accgccagta cctaagttag gctaacggag actttgacag gactggattt ttcttccacc     5160

agaagagaag ccttttccgt tggtttgggg ccacctcttt gaccatgacc atgtgatgtt     5220

ccgtttacag tgacttgctt tgggggaggg gaggctctct taaccgattc ccatgttgta     5280

cagtagatgg ttagaccttt tgtatattag tgtgttttaa gttattgatt tgttttatat     5340

aaaataattt atttttcagg tgccattttt cattttaact ttgtttttac atgggtttgt     5400

tttcaataaa gtctgacact ggtgtccaaa agtcaacaat aaaatgaatc ccattgtgtt     5460

cttttgaaga tgcctatgta acttttaagc tttttaaatt attttcagaa aaaaaaaaag     5520

aaaagccctt atcagttttc catcagccca ttgccttttt attttttttt tttaatcctt     5580

gtgaataaat gttctttagt gttttaggag gaaaaagcaa acctagattt tgataaccca     5640

gaagacttca gattaataaa gaagctttga aagaagacca tttttcaaaa ttttagtgaa     5700

gtgtgaatat tttttgtcaa tggctttctc aaagagaatg aaacttttgc accattttca     5760

gagtttttat agagatgcca aattgatata tttacatgta atggaaacat gaaaaagttt     5820

tattaaacaa ttgttcatag ctgtgtagac attttaattc agtttccaaa gctctcaaaa     5880

aatcgtattt ttgaagtacg gagtgatgcg gtttggggcg tggcttacag ttccaacgac     5940

tcaattgtcc cgatactcag ttctttctac aggtatcagg ttcgtgttaa acgctgtatg     6000

ttaactatga ctggaattct gtgatatttt ggtaataaat gaagtgggat cattgcgaaa     6060

aaaaaaaaaa aaaaa                                                      6075


<210>  15
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gln Ser Asn Lys Thr Phe Asn Leu Glu Lys Gln Asn His Thr Pro 
1               5                   10                  15      


Arg Lys His His Gln His His His Gln Gln Gln His His Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Pro Pro Pro Pro Pro Ile Pro Ala Asn Gly Gln Gln Ala 
        35                  40                  45              


Ser Ser Gln Asn Glu Gly Leu Thr Ile Asp Leu Lys Asn Phe Arg Lys 
    50                  55                  60                  


Pro Gly Glu Lys Thr Phe Thr Gln Arg Ser Arg Leu Phe Val Gly Asn 
65                  70                  75                  80  


Leu Pro Pro Asp Ile Thr Glu Glu Glu Met Arg Lys Leu Phe Glu Lys 
                85                  90                  95      


Tyr Gly Lys Ala Gly Glu Val Phe Ile His Lys Asp Lys Gly Phe Gly 
            100                 105                 110         


Phe Ile Arg Leu Glu Thr Arg Thr Leu Ala Glu Ile Ala Lys Val Glu 
        115                 120                 125             


Leu Asp Asn Met Pro Leu Arg Gly Lys Gln Leu Arg Val Arg Phe Ala 
    130                 135                 140                 


Cys His Ser Ala Ser Leu Thr Val Arg Asn Leu Pro Gln Tyr Val Ser 
145                 150                 155                 160 


Asn Glu Leu Leu Glu Glu Ala Phe Ser Val Phe Gly Gln Val Glu Arg 
                165                 170                 175     


Ala Val Val Ile Val Asp Asp Arg Gly Arg Pro Ser Gly Lys Gly Ile 
            180                 185                 190         


Val Glu Phe Ser Gly Lys Pro Ala Ala Arg Lys Ala Leu Asp Arg Cys 
        195                 200                 205             


Ser Glu Gly Ser Phe Leu Leu Thr Thr Phe Pro Arg Pro Val Thr Val 
    210                 215                 220                 


Glu Pro Met Asp Gln Leu Asp Asp Glu Glu Gly Leu Pro Glu Lys Leu 
225                 230                 235                 240 


Val Ile Lys Asn Gln Gln Phe His Lys Glu Arg Glu Gln Pro Pro Arg 
                245                 250                 255     


Phe Ala Gln Pro Gly Ser Phe Glu Tyr Glu Tyr Ala Met Arg Trp Lys 
            260                 265                 270         


Ala Leu Ile Glu Met Glu Lys Gln Gln Gln Asp Gln Val Asp Arg Asn 
        275                 280                 285             


Ile Lys Glu Ala Arg Glu Lys Leu Glu Met Glu Met Glu Ala Ala Arg 
    290                 295                 300                 


His Glu His Gln Val Met Leu Met Arg Gln Asp Leu Met Arg Arg Gln 
305                 310                 315                 320 


Glu Glu Leu Arg Arg Met Glu Glu Leu His Asn Gln Glu Val Gln Lys 
                325                 330                 335     


Arg Lys Gln Leu Glu Leu Arg Gln Glu Glu Glu Arg Arg Arg Arg Glu 
            340                 345                 350         


Glu Glu Met Arg Arg Gln Gln Glu Glu Met Met Arg Arg Gln Gln Glu 
        355                 360                 365             


Gly Phe Lys Gly Thr Phe Pro Asp Ala Arg Glu Gln Glu Ile Arg Met 
    370                 375                 380                 


Gly Gln Met Ala Met Gly Gly Ala Met Gly Ile Asn Asn Arg Gly Ala 
385                 390                 395                 400 


Met Pro Pro Ala Pro Val Pro Ala Gly Thr Pro Ala Pro Pro Gly Pro 
                405                 410                 415     


Ala Thr Met Met Pro Asp Gly Thr Leu Gly Leu Thr Pro Pro Thr Thr 
            420                 425                 430         


Glu Arg Phe Gly Gln Ala Ala Thr Met Glu Gly Ile Gly Ala Ile Gly 
        435                 440                 445             


Gly Thr Pro Pro Ala Phe Asn Arg Ala Ala Pro Gly Ala Glu Phe Ala 
    450                 455                 460                 


Pro Asn Lys Arg Arg Arg Tyr 
465                 470     


<210>  16
<211>  1229
<212>  DNA
<213>  Homo sapiens

<400>  16
atgcagagta ataaaacttt taacttggag aagcaaaacc atactccaag aaagcatcat       60

caacatcacc accagcagca gcaccaccag cagcaacagc agcagccgcc accaccgcca      120

atacctgcaa atgggcaaca ggccagcagc caaaatgaag gcttgactat tgacctgaag      180

aattttagaa aaccaggaga gaagaccttc acccaacgaa gccgtctttt tgtgggaaat      240

cttcctcccg acatcactga ggaagaaatg aggaaactat ttgagaaata tggaaaggca      300

ggcgaagtct tcattcataa ggataaagga tttggcttta tccgcttgga aacccgaacc      360

ctagcggaga ttgccaaagt ggagctggac aatatgccac tccgtggaaa ccagctgctc      420

ggaaagctct ggacagatgc agtgaaggct ccttcctgct aaccacattt cctcgtcctg      480

tgactgtgga gcccatggac cagttagatg atgaagaggg acttccagag aagctggtta      540

taaaaaacca gcaatttcac aaggaacgag agcagccacc cagatttgca cagcctggct      600

cctttgagta tgaatatgcc atgcgctgga aggcactcat tgagatggag aagcagcagc      660

aggaccaagt ggaccgcaac atcaaggagg ctcgtgagaa gctggagatg gagatggaag      720

ctgcacgcca tgagcaccag gtcatgctaa tgagacagga tttgatgagg cgccaagaag      780

aacttcggag gatggaagag ctgcacaacc aagaggtgca aaaacgaaag caactggagc      840

tcaggcagga ggaagagcgc aggcgccgtg aagaagagat gcggcggcag caagaagaaa      900

tgatgcggcg acagcaggaa ggattcaagg gaaccttccc tgatgcgaga gagcaggaga      960

ttcggatggg tcagatggct atgggaggtg ctatgggcat aaacaacaga ggtgccatgc     1020

cccctgctcc tgtgccagct ggtaccccag ctcctccagg acctgccact atgatgccgg     1080

atggaacttt gggattgacc ccaccaacaa ctgaacgctt tggtcaggct gctacaatgg     1140

aaggaattgg ggcaattggt ggaactcctc ctgcattcaa ccgtgcagct cctggagctg     1200

aatttgcccc aaacaaacgt cgccgatac                                       1229


<210>  17
<211>  636
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Asn Pro Ser Ala Pro Ser Tyr Pro Met Ala Ser Leu Tyr Val Gly 
1               5                   10                  15      


Asp Leu His Pro Asp Val Thr Glu Ala Met Leu Tyr Glu Lys Phe Ser 
            20                  25                  30          


Pro Ala Gly Pro Ile Leu Ser Ile Arg Val Cys Arg Asp Met Ile Thr 
        35                  40                  45              


Arg Arg Ser Leu Gly Tyr Ala Tyr Val Asn Phe Gln Gln Pro Ala Asp 
    50                  55                  60                  


Ala Glu Arg Ala Leu Asp Thr Met Asn Phe Asp Val Ile Lys Gly Lys 
65                  70                  75                  80  


Pro Val Arg Ile Met Trp Ser Gln Arg Asp Pro Ser Leu Arg Lys Ser 
                85                  90                  95      


Gly Val Gly Asn Ile Phe Ile Lys Asn Leu Asp Lys Ser Ile Asp Asn 
            100                 105                 110         


Lys Ala Leu Tyr Asp Thr Phe Ser Ala Phe Gly Asn Ile Leu Ser Cys 
        115                 120                 125             


Lys Val Val Cys Asp Glu Asn Gly Ser Lys Gly Tyr Gly Phe Val His 
    130                 135                 140                 


Phe Glu Thr Gln Glu Ala Ala Glu Arg Ala Ile Glu Lys Met Asn Gly 
145                 150                 155                 160 


Met Leu Leu Asn Asp Arg Lys Val Phe Val Gly Arg Phe Lys Ser Arg 
                165                 170                 175     


Lys Glu Arg Glu Ala Glu Leu Gly Ala Arg Ala Lys Glu Phe Thr Asn 
            180                 185                 190         


Val Tyr Ile Lys Asn Phe Gly Glu Asp Met Asp Asp Glu Arg Leu Lys 
        195                 200                 205             


Asp Leu Phe Gly Lys Phe Gly Pro Ala Leu Ser Val Lys Val Met Thr 
    210                 215                 220                 


Asp Glu Ser Gly Lys Ser Lys Gly Phe Gly Phe Val Ser Phe Glu Arg 
225                 230                 235                 240 


His Glu Asp Ala Gln Lys Ala Val Asp Glu Met Asn Gly Lys Glu Leu 
                245                 250                 255     


Asn Gly Lys Gln Ile Tyr Val Gly Arg Ala Gln Lys Lys Val Glu Arg 
            260                 265                 270         


Gln Thr Glu Leu Lys Arg Lys Phe Glu Gln Met Lys Gln Asp Arg Ile 
        275                 280                 285             


Thr Arg Tyr Gln Gly Val Asn Leu Tyr Val Lys Asn Leu Asp Asp Gly 
    290                 295                 300                 


Ile Asp Asp Glu Arg Leu Arg Lys Glu Phe Ser Pro Phe Gly Thr Ile 
305                 310                 315                 320 


Thr Ser Ala Lys Val Met Met Glu Gly Gly Arg Ser Lys Gly Phe Gly 
                325                 330                 335     


Phe Val Cys Phe Ser Ser Pro Glu Glu Ala Thr Lys Ala Val Thr Glu 
            340                 345                 350         


Met Asn Gly Arg Ile Val Ala Thr Lys Pro Leu Tyr Val Ala Leu Ala 
        355                 360                 365             


Gln Arg Lys Glu Glu Arg Gln Ala His Leu Thr Asn Gln Tyr Met Gln 
    370                 375                 380                 


Arg Met Ala Ser Val Arg Ala Val Pro Asn Pro Val Ile Asn Pro Tyr 
385                 390                 395                 400 


Gln Pro Ala Pro Pro Ser Gly Tyr Phe Met Ala Ala Ile Pro Gln Thr 
                405                 410                 415     


Gln Asn Arg Ala Ala Tyr Tyr Pro Pro Ser Gln Ile Ala Gln Leu Arg 
            420                 425                 430         


Pro Ser Pro Arg Trp Thr Ala Gln Gly Ala Arg Pro His Pro Phe Gln 
        435                 440                 445             


Asn Met Pro Gly Ala Ile Arg Pro Ala Ala Pro Arg Pro Pro Phe Ser 
    450                 455                 460                 


Thr Met Arg Pro Ala Ser Ser Gln Val Pro Arg Val Met Ser Thr Gln 
465                 470                 475                 480 


Arg Val Ala Asn Thr Ser Thr Gln Thr Met Gly Pro Arg Pro Ala Ala 
                485                 490                 495     


Ala Ala Ala Ala Ala Thr Pro Ala Val Arg Thr Val Pro Gln Tyr Lys 
            500                 505                 510         


Tyr Ala Ala Gly Val Arg Asn Pro Gln Gln His Leu Asn Ala Gln Pro 
        515                 520                 525             


Gln Val Thr Met Gln Gln Pro Ala Val His Val Gln Gly Gln Glu Pro 
    530                 535                 540                 


Leu Thr Ala Ser Met Leu Ala Ser Ala Pro Pro Gln Glu Gln Lys Gln 
545                 550                 555                 560 


Met Leu Gly Glu Arg Leu Phe Pro Leu Ile Gln Ala Met His Pro Thr 
                565                 570                 575     


Leu Ala Gly Lys Ile Thr Gly Met Leu Leu Glu Ile Asp Asn Ser Glu 
            580                 585                 590         


Leu Leu His Met Leu Glu Ser Pro Glu Ser Leu Arg Ser Lys Val Asp 
        595                 600                 605             


Glu Ala Val Ala Val Leu Gln Ala His Gln Ala Lys Glu Ala Ala Gln 
    610                 615                 620                 


Lys Ala Val Asn Ser Ala Thr Gly Val Pro Thr Val 
625                 630                 635     


<210>  18
<211>  2869
<212>  DNA
<213>  Homo sapiens

<400>  18
cccttctccc cggcggttag tgctgagagt gcggagtgtg tgctccgggc tcggaacaca       60

catttattat taaaaaatcc aaaaaaaatc taaaaaaatc ttttaaaaaa ccccaaaaaa      120

atttacaaaa aatccgcgtc tcccccgccg gagactttta ttttttttct tcctctttta      180

taaaataacc cggtgaagca gccgagaccg acccgcccgc ccgcggcccc gcagcagctc      240

caagaaggaa ccaagagacc gaggccttcc cgctgcccgg acccgacacc gccaccctcg      300

ctccccgccg gcagccggca gccagcggca gtggatcgac cccgttctgc ggccgttgag      360

tagttttcaa ttccggttga tttttgtccc tctgcgcttg ctccccgctc ccctcccccc      420

ggctccggcc cccagccccg gcactcgctc tcctcctctc acggaaaggt cgcggcctgt      480

ggccctgcgg gcagccgtgc cgagatgaac cccagtgccc ccagctaccc catggcctcg      540

ctctacgtgg gggacctcca ccccgacgtg accgaggcga tgctctacga gaagttcagc      600

ccggccgggc ccatcctctc catccgggtc tgcagggaca tgatcacccg ccgctccttg      660

ggctacgcgt atgtgaactt ccagcagccg gcggacgcgg agcgtgcttt ggacaccatg      720

aattttgatg ttataaaggg caagccagta cgcatcatgt ggtctcagcg tgatccatca      780

cttcgcaaaa gtggagtagg caacatattc attaaaaatc tggacaaatc cattgataat      840

aaagcactgt atgatacatt ttctgctttt ggtaacatcc tttcatgtaa ggtggtttgt      900

gatgaaaatg gttccaaggg ctatggattt gtacactttg agacgcagga agcagctgaa      960

agagctattg aaaaaatgaa tggaatgctc ctaaatgatc gcaaagtatt tgttggacga     1020

tttaagtctc gtaaagaacg agaagctgaa cttggagcta gggcaaaaga attcaccaat     1080

gtttacatca agaattttgg agaagacatg gatgatgagc gccttaagga tctctttggc     1140

aagtttgggc ctgccttaag tgtgaaagta atgactgatg aaagtggaaa atccaaagga     1200

tttggatttg taagctttga aaggcatgaa gatgcacaga aagctgtgga tgagatgaac     1260

ggaaaggagc tcaatggaaa acaaatttat gttggtcgag ctcagaaaaa ggtggaacgg     1320

cagacggaac ttaagcgcaa atttgaacag atgaaacaag ataggatcac cagataccag     1380

ggtgttaatc tttatgtgaa aaatcttgat gatggtattg atgatgaacg tctccggaaa     1440

gagttttctc catttggtac aatcactagt gcaaaggtta tgatggaggg tggtcgcagc     1500

aaagggtttg gttttgtatg tttctcctcc ccagaagaag ccactaaagc agttacagaa     1560

atgaacggta gaattgtggc cacaaagcca ttgtatgtag ctttagctca gcgcaaagaa     1620

gagcgccagg ctcacctcac taaccagtat atgcagagaa tggcaagtgt acgagctgtt     1680

cccaaccctg taatcaaccc ctaccagcca gcacctcctt caggttactt catggcagct     1740

atcccacaga ctcagaaccg tgctgcatac tatcctccta gccaaattgc tcaactaaga     1800

ccaagtcctc gctggactgc tcagggtgcc agacctcatc cattccaaaa tatgcccggt     1860

gctatccgcc cagctgctcc tagaccacca tttagtacta tgagaccagc ttcttcacag     1920

gttccacgag tcatgtcaac acagcgtgtt gctaacacat caacacagac aatgggtcca     1980

cgtcctgcag ctgcagccgc tgcagctact cctgctgtcc gcaccgttcc acagtataaa     2040

tatgctgcag gagttcgcaa tcctcagcaa catcttaatg cacagccaca agttacaatg     2100

caacagcctg ctgttcatgt acaaggtcag gaacctttga ctgcttccat gttggcatct     2160

gcccctcctc aagagcaaaa gcaaatgttg ggtgaacggc tgtttcctct tattcaagcc     2220

atgcacccta ctcttgctgg taaaatcact ggcatgttgt tggagattga taattcagaa     2280

cttcttcata tgctcgagtc tccagagtca ctccgttcta aggttgatga agctgtagct     2340

gtactacaag cccaccaagc taaagaggct gcccagaaag cagttaacag tgccaccggt     2400

gttccaactg tttaaaattg atcagggacc atgaaaagaa acttgtgctt caccgaagaa     2460

aaatatctaa acatcgaaaa acttaaatat tatggaaaaa aaacattgca aaatataaaa     2520

taaataaaaa aaggaaagga aactttgaac cttatgtacc gagcaaatgc caggtctagc     2580

aaacataatg ctagtcctag attacttatt gatttaaaaa caaaaaaaca caaaaaaata     2640

gtaaaatata aaaacaaatt aatgttttat agaccctggg aaaaagaatt ttcagcaaag     2700

tacaaaaatt taaagcattc ctttctttaa ttttgtaatt ctttactgtg gaatagctca     2760

gaatgtcagt tctgttttaa gtaacagaat tgataactga gcaaggaaac gtaatttgga     2820

ttataaaatt cttgctttaa taaaaattcc ttaaacagtg aaaaaaaaa                 2869


<210>  19
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Asp Asp Ala Gly Ala Ala Gly Gly Pro Gly Gly Pro Gly Gly 
1               5                   10                  15      


Pro Gly Met Gly Asn Arg Gly Gly Phe Arg Gly Gly Phe Gly Ser Gly 
            20                  25                  30          


Ile Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
        35                  40                  45              


Gly Ala Arg Gly Gly Lys Ala Glu Asp Lys Glu Trp Met Pro Val Thr 
    50                  55                  60                  


Lys Leu Gly Arg Leu Val Lys Asp Met Lys Ile Lys Ser Leu Glu Glu 
65                  70                  75                  80  


Ile Tyr Leu Phe Ser Leu Pro Ile Lys Glu Ser Glu Ile Ile Asp Phe 
                85                  90                  95      


Phe Leu Gly Ala Ser Leu Lys Asp Glu Val Leu Lys Ile Met Pro Val 
            100                 105                 110         


Gln Lys Gln Thr Arg Ala Gly Gln Arg Thr Arg Phe Lys Ala Phe Val 
        115                 120                 125             


Ala Ile Gly Asp Tyr Asn Gly His Val Gly Leu Gly Val Lys Cys Ser 
    130                 135                 140                 


Lys Glu Val Ala Thr Ala Ile Arg Gly Ala Ile Ile Leu Ala Lys Leu 
145                 150                 155                 160 


Ser Ile Val Pro Val Arg Arg Gly Tyr Trp Gly Asn Lys Ile Gly Lys 
                165                 170                 175     


Pro His Thr Val Pro Cys Lys Val Thr Gly Arg Cys Gly Ser Val Leu 
            180                 185                 190         


Val Arg Leu Ile Pro Ala Pro Arg Gly Thr Gly Ile Val Ser Ala Pro 
        195                 200                 205             


Val Pro Lys Lys Leu Leu Met Met Ala Gly Ile Asp Asp Cys Tyr Thr 
    210                 215                 220                 


Ser Ala Arg Gly Cys Thr Ala Thr Leu Gly Asn Phe Ala Lys Ala Thr 
225                 230                 235                 240 


Phe Asp Ala Ile Ser Lys Thr Tyr Ser Tyr Leu Thr Pro Asp Leu Trp 
                245                 250                 255     


Lys Glu Thr Val Phe Thr Lys Ser Pro Tyr Gln Glu Phe Thr Asp His 
            260                 265                 270         


Leu Val Lys Thr His Thr Arg Val Ser Val Gln Arg Thr Gln Ala Pro 
        275                 280                 285             


Ala Val Ala Thr Thr 
    290             


<210>  20
<211>  962
<212>  DNA
<213>  Homo sapiens

<400>  20
cttcttttcc gacaaaacac caaatggcgg atgacgccgg tgcagcgggg gggcccgggg       60

gccctggtgg ccctgggatg gggaaccgcg gtggcttccg cggaggtttc ggcagtggca      120

tccggggccg gggtcgcggc cgtggacggg gccggggccg aggccgcgga gctcgcggag      180

gcaaggccga ggataaggag tggatgcccg tcaccaagtt gggccgcttg gtcaaggaca      240

tgaagatcaa gtccctggag gagatctatc tcttctccct gcctattaag gaatcagaga      300

tcattgattt cttcctgggg gcctctctca aggatgaggt tttgaagatt atgccagtgc      360

agaagcagac ccgtgccggc cagcgcacca ggttcaaggc atttgttgct atcggggact      420

acaatggcca cgtcggtctg ggtgttaagt gctccaagga ggtggccacc gccatccgtg      480

gggccatcat cctggccaag ctctccatcg tccccgtgcg cagaggctac tgggggaaca      540

agatcggcaa gccccacact gtcccttgca aggtgacagg ccgctgcggc tctgtgctgg      600

tacgcctcat ccctgcaccc aggggcactg gcatcgtctc cgcacctgtg cctaagaagc      660

tgctcatgat ggctggtatc gatgactgct acacctcagc ccggggctgc actgccaccc      720

tgggcaactt cgccaaggcc acctttgatg ccatttctaa gacctacagc tacctgaccc      780

ccgacctctg gaaggagact gtattcacca agtctcccta tcaggagttc actgaccacc      840

tcgtcaagac ccacaccaga gtctccgtgc agcggactca ggctccagct gtggctacaa      900

catagggttt ttatacaaga aaaataaagt gaattaagcg tgaaaaaaaa aaaaaaaaaa      960

aa                                                                     962


<210>  21
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ser Glu Tyr Ile Arg Val Thr Glu Asp Glu Asn Asp Glu Pro Ile 
1               5                   10                  15      


Glu Ile Pro Ser Glu Asp Asp Gly Thr Val Leu Leu Ser Thr Val Thr 
            20                  25                  30          


Ala Gln Phe Pro Gly Ala Cys Gly Leu Arg Tyr Arg Asn Pro Val Ser 
        35                  40                  45              


Gln Cys Met Arg Gly Val Arg Leu Val Glu Gly Ile Leu His Ala Pro 
    50                  55                  60                  


Asp Ala Gly Trp Gly Asn Leu Val Tyr Val Val Asn Tyr Pro Lys Asp 
65                  70                  75                  80  


Asn Lys Arg Lys Met Asp Glu Thr Asp Ala Ser Ser Ala Val Lys Val 
                85                  90                  95      


Lys Arg Ala Val Gln Lys Thr Ser Asp Leu Ile Val Leu Gly Leu Pro 
            100                 105                 110         


Trp Lys Thr Thr Glu Gln Asp Leu Lys Glu Tyr Phe Ser Thr Phe Gly 
        115                 120                 125             


Glu Val Leu Met Val Gln Val Lys Lys Asp Leu Lys Thr Gly His Ser 
    130                 135                 140                 


Lys Gly Phe Gly Phe Val Arg Phe Thr Glu Tyr Glu Thr Gln Val Lys 
145                 150                 155                 160 


Val Met Ser Gln Arg His Met Ile Asp Gly Arg Trp Cys Asp Cys Lys 
                165                 170                 175     


Leu Pro Asn Ser Lys Gln Ser Gln Asp Glu Pro Leu Arg Ser Arg Lys 
            180                 185                 190         


Val Phe Val Gly Arg Cys Thr Glu Asp Met Thr Glu Asp Glu Leu Arg 
        195                 200                 205             


Glu Phe Phe Ser Gln Tyr Gly Asp Val Met Asp Val Phe Ile Pro Lys 
    210                 215                 220                 


Pro Phe Arg Ala Phe Ala Phe Val Thr Phe Ala Asp Asp Gln Ile Ala 
225                 230                 235                 240 


Gln Ser Leu Cys Gly Glu Asp Leu Ile Ile Lys Gly Ile Ser Val His 
                245                 250                 255     


Ile Ser Asn Ala Glu Pro Lys His Asn Ser Asn Arg Gln Leu Glu Arg 
            260                 265                 270         


Ser Gly Arg Phe Gly Gly Asn Pro Gly Gly Phe Gly Asn Gln Gly Gly 
        275                 280                 285             


Phe Gly Asn Ser Arg Gly Gly Gly Ala Gly Leu Gly Asn Asn Gln Gly 
    290                 295                 300                 


Ser Asn Met Gly Gly Gly Met Asn Phe Gly Ala Phe Ser Ile Asn Pro 
305                 310                 315                 320 


Ala Met Met Ala Ala Ala Gln Ala Ala Leu Gln Ser Ser Trp Gly Met 
                325                 330                 335     


Met Gly Met Leu Ala Ser Gln Gln Asn Gln Ser Gly Pro Ser Gly Asn 
            340                 345                 350         


Asn Gln Asn Gln Gly Asn Met Gln Arg Glu Pro Asn Gln Ala Phe Gly 
        355                 360                 365             


Ser Gly Asn Asn Ser Tyr Ser Gly Ser Asn Ser Gly Ala Ala Ile Gly 
    370                 375                 380                 


Trp Gly Ser Ala Ser Asn Ala Gly Ser Gly Ser Gly Phe Asn Gly Gly 
385                 390                 395                 400 


Phe Gly Ser Ser Met Asp Ser Lys Ser Ser Gly Trp Gly Met 
                405                 410                 


<210>  22
<211>  1251
<212>  DNA
<213>  Homo sapiens

<400>  22
atgtctgaat atattcgggt aaccgaagat gagaacgatg agcccattga aataccatcg       60

gaagacgatg ggacggtgct gctctccacg gttacagccc agtttccagg ggcgtgtggg      120

cttcgctaca ggaatccagt gtctcagtgt atgagaggtg tccggctggt agaaggaatt      180

ctgcatgccc cagatgctgg ctggggaaat ctggtgtatg ttgtcaacta tccaaaagat      240

aacaaaagaa aaatggatga gacagatgct tcatcagcag tgaaagtgaa aagagcagtc      300

cagaaaacat ccgatttaat agtgttgggt ctcccatgga aaacaaccga acaggacctg      360

aaagagtatt ttagtacctt tggagaagtt cttatggtgc aggtcaagaa agatcttaag      420

actggtcatt caaaggggtt tggctttgtt cgttttacgg aatatgaaac acaagtgaaa      480

gtaatgtcac agcgacatat gatagatgga cgatggtgtg actgcaaact tcctaattct      540

aagcaaagcc aagatgagcc tttgagaagc agaaaagtgt ttgtggggcg ctgtacagag      600

gacatgactg aggatgagct gcgggagttc ttctctcagt acggggatgt gatggatgtc      660

ttcatcccca agccattcag ggcctttgcc tttgttacat ttgcagatga tcagattgcg      720

cagtctcttt gtggagagga cttgatcatt aaaggaatca gcgttcatat atccaatgcc      780

gaacctaagc acaatagcaa tagacagtta gaaagaagtg gaagatttgg tggtaatcca      840

ggtggctttg ggaatcaggg tggatttggt aatagcagag ggggtggagc tggtttggga      900

aacaatcaag gtagtaatat gggtggtggg atgaactttg gtgcgttcag cattaatcca      960

gccatgatgg ctgccgccca ggcagcacta cagagcagtt ggggtatgat gggcatgtta     1020

gccagccagc agaaccagtc aggcccatcg ggtaataacc aaaaccaagg caacatgcag     1080

agggagccaa accaggcctt cggttctgga aataactctt atagtggctc taattctggt     1140

gcagcaattg gttggggatc agcatccaat gcagggtcgg gcagtggttt taatggaggc     1200

tttggctcaa gcatggattc taagtcttct ggctggggaa tgaatcacta g              1251


<210>  23
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asn Lys Leu Tyr Ile Gly Asn Leu Asn Glu Ser Val Thr Pro Ala 
1               5                   10                  15      


Asp Leu Glu Lys Val Phe Ala Glu His Lys Ile Ser Tyr Ser Gly Gln 
            20                  25                  30          


Phe Leu Val Lys Ser Gly Tyr Ala Phe Val Asp Cys Pro Asp Glu His 
        35                  40                  45              


Trp Ala Met Lys Ala Ile Glu Thr Phe Ser Gly Lys Val Glu Leu Gln 
    50                  55                  60                  


Gly Lys Arg Leu Glu Ile Glu His Ser Val Pro Lys Lys Gln Arg Ser 
65                  70                  75                  80  


Arg Lys Ile Gln Ile Arg Asn Ile Pro Pro Gln Leu Arg Trp Glu Val 
                85                  90                  95      


Leu Asp Ser Leu Leu Ala Gln Tyr Gly Thr Val Glu Asn Cys Glu Gln 
            100                 105                 110         


Val Asn Thr Glu Ser Glu Thr Ala Val Val Asn Val Thr Tyr Ser Asn 
        115                 120                 125             


Arg Glu Gln Thr Arg Gln Ala Ile Met Lys Leu Asn Gly His Gln Leu 
    130                 135                 140                 


Glu Asn His Ala Leu Lys Val Ser Tyr Ile Pro Asp Glu Gln Ile Ala 
145                 150                 155                 160 


Gln Gly Pro Glu Asn Gly Arg Arg Gly Gly Phe Gly Ser Arg Gly Gln 
                165                 170                 175     


Pro Arg Gln Gly Ser Pro Val Ala Ala Gly Ala Pro Ala Lys Gln Gln 
            180                 185                 190         


Gln Val Asp Ile Pro Leu Arg Leu Leu Val Pro Thr Gln Tyr Val Gly 
        195                 200                 205             


Ala Ile Ile Gly Lys Glu Gly Ala Thr Ile Arg Asn Ile Thr Lys Gln 
    210                 215                 220                 


Thr Gln Ser Lys Ile Asp Val His Arg Lys Glu Asn Ala Gly Ala Ala 
225                 230                 235                 240 


Glu Lys Ala Ile Ser Val His Ser Thr Pro Glu Gly Cys Ser Ser Ala 
                245                 250                 255     


Cys Lys Met Ile Leu Glu Ile Met His Lys Glu Ala Lys Asp Thr Lys 
            260                 265                 270         


Thr Ala Asp Glu Val Pro Leu Lys Ile Leu Ala His Asn Asn Phe Val 
        275                 280                 285             


Gly Arg Leu Ile Gly Lys Glu Gly Arg Asn Leu Lys Lys Val Glu Gln 
    290                 295                 300                 


Asp Thr Glu Thr Lys Ile Thr Ile Ser Ser Leu Gln Asp Leu Thr Leu 
305                 310                 315                 320 


Tyr Asn Pro Glu Arg Thr Ile Thr Val Lys Gly Ala Ile Glu Asn Cys 
                325                 330                 335     


Cys Arg Ala Glu Gln Glu Ile Met Lys Lys Val Arg Glu Ala Tyr Glu 
            340                 345                 350         


Asn Asp Val Ala Ala Met Ser Leu Gln Ser His Leu Ile Pro Gly Leu 
        355                 360                 365             


Asn Leu Ala Ala Val Gly Leu Phe Pro Ala Ser Ser Ser Ala Val Pro 
    370                 375                 380                 


Pro Pro Pro Ser Ser Val Thr Gly Ala Ala Pro Tyr Ser Ser Phe Met 
385                 390                 395                 400 


Gln Ala Pro Glu Gln Glu Met Val Gln Val Phe Ile Pro Ala Gln Ala 
                405                 410                 415     


Val Gly Ala Ile Ile Gly Lys Lys Gly Gln His Ile Lys Gln Leu Ser 
            420                 425                 430         


Arg Phe Ala Ser Ala Ser Ile Lys Ile Ala Pro Pro Glu Thr Pro Asp 
        435                 440                 445             


Ser Lys Val Arg Met Val Ile Ile Thr Gly Pro Pro Glu Ala Gln Phe 
    450                 455                 460                 


Lys Ala Gln Gly Arg Ile Tyr Gly Lys Leu Lys Glu Glu Asn Phe Phe 
465                 470                 475                 480 


Gly Pro Lys Glu Glu Val Lys Leu Glu Thr His Ile Arg Val Pro Ala 
                485                 490                 495     


Ser Ala Ala Gly Arg Val Ile Gly Lys Gly Gly Lys Thr Val Asn Glu 
            500                 505                 510         


Leu Gln Asn Leu Thr Ala Ala Glu Val Val Val Pro Arg Asp Gln Thr 
        515                 520                 525             


Pro Asp Glu Asn Asp Gln Val Ile Val Lys Ile Ile Gly His Phe Tyr 
    530                 535                 540                 


Ala Ser Gln Met Ala Gln Arg Lys Ile Arg Asp Ile Leu Ala Gln Val 
545                 550                 555                 560 


Lys Gln Gln His Gln Lys Gly Gln Ser Asn Gln Ala Gln Ala Arg Arg 
                565                 570                 575     


Lys 
    


<210>  24
<211>  2381
<212>  DNA
<213>  Homo sapiens

<400>  24
agaaacgtga cacaccagcc ctctcggagg ggtttcggac cgaagggaag aagctgcgcc       60

gtgtcgtccg tctccctgcg cgccgcgggc acttctcctg ggctctcccc gaactctccc      120

gcgacctctg cgcgccctca ggccgccttc cccgccctgg gctcgggaca acttctgggg      180

tggggtgcaa agaaagtttg cggctcctgc cgccggcctc tccgcctctt ggcctaggag      240

gctcgccgcc cgcgcccgct cgttcggcct tgcccgggac cgcgtcctgc cccgagaccg      300

ccaccatgaa caagctttac atcggcaacc tcaacgagag cgtgaccccc gcggacttgg      360

agaaagtgtt tgcggagcac aagatctcct acagcggcca gttcttggtc aaatccggct      420

acgccttcgt ggactgcccg gacgagcact gggcgatgaa ggccatcgaa actttctccg      480

ggaaagtaga attacaagga aaacgcttag agattgaaca ttcggtgccc aaaaaacaaa      540

ggagccggaa aattcaaatc cgaaatattc caccccagct ccgatgggaa gtactggaca      600

gcctgctggc tcagtatggt acagtagaga actgtgagca agtgaacacc gagagtgaga      660

cggcagtggt gaatgtcacc tattccaacc gggagcagac caggcaagcc atcatgaagc      720

tgaatggcca ccagttggag aaccatgccc tgaaggtctc ctacatcccc gatgagcaga      780

tagcacaggg acctgagaat gggcgccgag ggggctttgg ctctcggggt cagccccgcc      840

agggctcacc tgtggcagcg ggggccccag ccaagcagca gcaagtggac atcccccttc      900

ggctcctggt gcccacccag tatgtgggtg ccattattgg caaggagggg gccaccatcc      960

gcaacatcac aaaacagacc cagtccaaga tagacgtgca taggaaggag aacgcaggtg     1020

cagctgaaaa agccatcagt gtgcactcca cccctgaggg ctgctcctcc gcttgtaaga     1080

tgatcttgga gattatgcat aaagaggcta aggacaccaa aacggctgac gaggttcccc     1140

tgaagaccct ggcccataat aactttgtag ggcgtctcat tggcaaggaa ggacggaacc     1200

tgaagaaggt agagcaagat accgagacaa aaatcaccat ctcctcgttg caagacctta     1260

ccctttacaa ccctgagagg accatcactg tgaagggggc catcgagaat tgttgcaggg     1320

ccgagcagga aataatgaag aaagttcggg aggcctatga gaatgatgtg gctgccatga     1380

gcctgcagtc tcacctgacc cctggcctga acctggctgc tgtaggtctt ttcccagctt     1440

catccagcgc agtcccgccg cctcccagca gcgttactgg ggctgctccc tatagctcct     1500

ttatgcaggc tcccgagcag gagatggtgc aggtgtttat ccccgcccag gcagtgggcg     1560

ccatcatcgg caagaagggg cagcacatca aacagctctc ccggtttgcc agcgcctcca     1620

tcaagattgc accacccgaa acacctgact ccaaagttcg tatggttatc atcactggac     1680

cgccagaggc ccaattcaag gctcagggaa gaatctatgg caaactcaag gaggagaact     1740

tctttggtcc caaggaggaa gtgaagctgg agacccacat acgtgtgcca gcatcagcag     1800

ctggccgggt cattggcaaa ggtggaaaaa cggtgaacga gttgcagaat ttgacggcag     1860

ctgaggtggt agtaccaaga gaccagaccc ctgatgagaa cgaccaggtc atcgtgaaaa     1920

tcatcggaca tttctatgcc agtcagatgg ctcaacggaa gatccgagac atcctggccc     1980

aggttaagca gcagcatcag aagggacaga gtaaccaggc ccaggcacga aggaagtgac     2040

cagcccctcc ctgtcccttc gagtccagga caacaacggg cagaaatcga gagtgtgctc     2100

tccccggcag gcctgagaat gagtgggaat ccgggacacc tgggccgggc tgtagatcag     2160

gtttgcccac ttgattgaga aagatgttcc agtgaggaac cctgatctct cagcccccaa     2220

acacctaccc aattggccca acactgtctg cccctcgggg tgtcagaaat tctagcgcaa     2280

ggcactttta aacgtggatt gtttaaagaa gctctccagg ccccaccaag agggtggatc     2340

acacctcagt gggaagaaaa ataaaatttc cttcaggttt t                         2381


<210>  25
<211>  6
<212>  DNA
<213>  Drosophila melanogaster

<400>  25
vbyrvs                                                                   6


<210>  26
<211>  10
<212>  DNA
<213>  Drosophila melanogaster


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  n is a, c, g, or t

<400>  26
wwnnhnndww                                                              10


<210>  27
<211>  10
<212>  DNA
<213>  Drosophila melanogaster


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, or t

<400>  27
wwnhnhdnwd                                                              10


<210>  28
<211>  10
<212>  DNA
<213>  Drosophila melanogaster

<400>  28
tabrhatryd                                                              10


<210>  29
<211>  10
<212>  DNA
<213>  Drosophila melanogaster


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<400>  29
nayrtatgbv                                                              10


<210>  30
<211>  10
<212>  DNA
<213>  Drosophila melanogaster


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  n is a, c, g, or t

<400>  30
nnwhhrnnhw                                                              10


<210>  31
<211>  10
<212>  DNA
<213>  Drosophila melanogaster


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<400>  31
bdsyndvrgb                                                              10


<210>  32
<211>  8
<212>  DNA
<213>  Drosophila melanogaster

<400>  32
tgtrtgta                                                                 8


<210>  33
<211>  8
<212>  DNA
<213>  Drosophila melanogaster


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<400>  33
gcngcngc                                                                 8


<210>  34
<211>  8
<212>  DNA
<213>  Drosophila melanogaster

<400>  34
tttdtttt                                                                 8


<210>  35
<211>  10
<212>  DNA
<213>  Drosophila melanogaster

<400>  35
tdtdtdtdtd                                                              10


<210>  36
<211>  10
<212>  DNA
<213>  Drosophila melanogaster


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is a, c, g, or t

<400>  36
ryrvasmnrn                                                              10


<210>  37
<211>  10
<212>  DNA
<213>  Drosophila melanogaster

<400>  37
rmaamvmaaa                                                              10


<210>  38
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  38

Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro Val 
1               5                   10                  


<210>  39
<211>  14
<212>  PRT
<213>  Rattus norvegicus

<400>  39

Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro Val 
1               5                   10                  


<210>  40
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  40

Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro Val 
1               5                   10                  


<210>  41
<211>  14
<212>  PRT
<213>  Gallus gallus

<400>  41

Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro Val 
1               5                   10                  


<210>  42
<211>  14
<212>  PRT
<213>  Drosophila melanogaster

<400>  42

Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro Val 
1               5                   10                  


<210>  43
<211>  14
<212>  PRT
<213>  Takifugu rubripes

<400>  43

Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro Val 
1               5                   10                  


<210>  44
<211>  14
<212>  PRT
<213>  Danio rerio

<400>  44

Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro Val 
1               5                   10                  


<210>  45
<211>  14
<212>  PRT
<213>  Doryteuthis opalescens

<400>  45

Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Ile Pro Val 
1               5                   10                  


<210>  46
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  46

Leu Arg Thr Lys Ile Glu Ser Gly Glu Gly Thr Val Pro Val 
1               5                   10                  


<210>  47
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  47

Leu Arg Thr Lys Val Glu Asn Gly Glu Gly Thr Ile Pro Val 
1               5                   10                  


<210>  48
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  48

Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Ser Ala Ile Glu Val 
1               5                   10                  15      


Ile Asn Ala Thr 
            20  


<210>  49
<211>  20
<212>  PRT
<213>  Rattus norvegicus

<400>  49

Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Thr Ala Ile Glu Val 
1               5                   10                  15      


Ile Asn Ala Thr 
            20  


<210>  50
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  50

Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Ala Thr Ile Glu Val 
1               5                   10                  15      


Ile Asn Ala Thr 
            20  


<210>  51
<211>  20
<212>  PRT
<213>  Gallus gallus

<400>  51

Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Thr Gly Leu Glu Val 
1               5                   10                  15      


Ile Asn Ala Thr 
            20  


<210>  52
<211>  20
<212>  PRT
<213>  Drosophila melanogaster

<400>  52

Pro Asn Phe Gly Ile Asn Trp Thr Ile Gly Asp Thr Glu Leu Glu Val 
1               5                   10                  15      


Val Asn Ser Leu 
            20  


<210>  53
<211>  21
<212>  PRT
<213>  Takifugu rubripes

<400>  53

Pro Asn Phe Arg Val Asn Trp Thr Val Gly Asp Asn Gln Gly Leu Lys 
1               5                   10                  15      


Val Ile Asn Ala Thr 
            20      


<210>  54
<211>  20
<212>  PRT
<213>  Danio rerio

<400>  54

Pro Asn Phe Ser Val Asn Trp Thr Val Gly Asp Gln Gly Leu Glu Ile 
1               5                   10                  15      


Ile Asn Ala Thr 
            20  


<210>  55
<211>  20
<212>  PRT
<213>  Doryteuthis opalescens

<400>  55

Pro Asn Phe Gly Ile Asn Trp Arg Arg Asn Asp Asp Ser Phe Glu Val 
1               5                   10                  15      


Ile Asn Ala Met 
            20  


<210>  56
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  56

Pro Pro Phe Ser Met Asn Trp Val Val Gly Ser Ala Asp Leu Glu Ile 
1               5                   10                  15      


Ile Asn Ala Thr 
            20  


<210>  57
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  57

Lys Glu Thr Ser Val Asn Trp Cys Leu Ala Asp Gly Tyr Asp Leu Glu 
1               5                   10                  15      


Ile Leu Asp Gly Thr 
            20      


