                         SEQUENCE LISTING

<110>  STC.UNM
       Deretic, Vojo
 
<120>  TRIM PROTEINS AND GALECTINS COOPERATE AND CODIRECT AUTOPHAGY  
       AND ARE USEFUL IN THE TREATMENT OF AUTOPHAGY RELATED DISEASES

<130>  N12-296PCT

<150>  62/368,624
<151>  2016-07-29

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Glu Asn Trp Lys Asn Cys Phe Glu Glu Glu Leu Ile Cys Pro 
1               5                   10                  15      


Ile Cys Leu His Val Phe Val Glu Pro Val Gln Leu Pro Cys Lys His 
            20                  25                  30          


Asn Phe Cys Arg Gly Cys Ile Gly Glu Ala Trp Ala Lys Asp Ser Gly 
        35                  40                  45              


Leu Val Arg Cys Pro Glu Cys Asn Gln Ala Tyr Asn Gln Lys Pro Gly 
    50                  55                  60                  


Leu Glu Lys Asn Leu Lys Leu Thr Asn Ile Val Glu Lys Phe Asn Ala 
65                  70                  75                  80  


Leu His Val Glu Lys Pro Pro Ala Ala Leu His Cys Val Phe Cys Arg 
                85                  90                  95      


Arg Gly Pro Pro Leu Pro Ala Gln Lys Val Cys Leu Arg Cys Glu Ala 
            100                 105                 110         


Pro Cys Cys Gln Ser His Val Gln Thr His Leu Gln Gln Pro Ser Thr 
        115                 120                 125             


Ala Arg Gly His Leu Leu Val Glu Ala Asp Asp Val Arg Ala Trp Ser 
    130                 135                 140                 


Cys Pro Gln His Asn Ala Tyr Arg Leu Tyr His Cys Glu Ala Glu Gln 
145                 150                 155                 160 


Val Ala Val Cys Gln Tyr Cys Cys Tyr Tyr Ser Gly Ala His Gln Gly 
                165                 170                 175     


His Ser Val Cys Asp Val Glu Ile Arg Arg Asn Glu Ile Arg Lys Met 
            180                 185                 190         


Leu Met Lys Gln Gln Asp Arg Leu Glu Glu Arg Glu Gln Asp Ile Glu 
        195                 200                 205             


Asp Gln Leu Tyr Lys Leu Glu Ser Asp Lys Arg Leu Val Glu Glu Lys 
    210                 215                 220                 


Val Asn Gln Leu Lys Glu Glu Val Arg Leu Gln Tyr Glu Lys Leu His 
225                 230                 235                 240 


Gln Leu Leu Asp Glu Asp Leu Arg Gln Thr Val Glu Val Leu Asp Lys 
                245                 250                 255     


Ala Gln Ala Lys Phe Cys Ser Glu Asn Ala Ala Gln Ala Leu His Leu 
            260                 265                 270         


Gly Glu Arg Met Gln Glu Ala Lys Lys Leu Leu Gly Ser Leu Gln Leu 
        275                 280                 285             


Leu Phe Asp Lys Thr Glu Asp Val Ser Phe Met Lys Asn Thr Lys Ser 
    290                 295                 300                 


Val Lys Ile Leu Met Asp Arg Thr Gln Thr Cys Thr Ser Ser Ser Leu 
305                 310                 315                 320 


Ser Pro Thr Lys Ile Gly His Leu Asn Ser Lys Leu Phe Leu Asn Glu 
                325                 330                 335     


Val Ala Lys Lys Glu Lys Gln Leu Arg Lys Met Leu Glu Gly Pro Phe 
            340                 345                 350         


Ser Thr Pro Val Pro Phe Leu Gln Ser Val Pro Leu Tyr Pro Cys Gly 
        355                 360                 365             


Val Ser Ser Ser Gly Ala Glu Lys Arg Lys His Ser Thr Ala Phe Pro 
    370                 375                 380                 


Glu Ala Ser Phe Leu Glu Thr Ser Ser Gly Pro Val Gly Gly Gln Tyr 
385                 390                 395                 400 


Gly Ala Ala Gly Thr Ala Ser Gly Glu Gly Gln Ser Gly Gln Pro Leu 
                405                 410                 415     


Gly Pro Cys Ser Ser Thr Gln His Leu Val Ala Leu Pro Gly Gly Ala 
            420                 425                 430         


Gln Pro Val His Ser Ser Pro Val Phe Pro Pro Ser Gln Tyr Pro Asn 
        435                 440                 445             


Gly Ser Ala Ala Gln Gln Pro Met Leu Pro Gln Tyr Gly Gly Arg Lys 
    450                 455                 460                 


Ile Leu Val Cys Ser Val Asp Asn Cys Tyr Cys Ser Ser Val Ala Asn 
465                 470                 475                 480 


His Gly Gly His Gln Pro Tyr Pro Arg Ser Gly His Phe Pro Trp Thr 
                485                 490                 495     


Val Pro Ser Gln Glu Tyr Ser His Pro Leu Pro Pro Thr Pro Ser Val 
            500                 505                 510         


Pro Gln Ser Leu Pro Ser Leu Ala Val Arg Asp Trp Leu Asp Ala Ser 
        515                 520                 525             


Gln Gln Pro Gly His Gln Asp Phe Tyr Arg Val Tyr Gly Gln Pro Ser 
    530                 535                 540                 


Thr Lys His Tyr Val Thr Ser 
545                 550     


<210>  2
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Ala Ala Ser Val Thr Ser Leu Ala Asp Glu Val Asn Cys 
1               5                   10                  15      


Pro Ile Cys Gln Gly Thr Leu Arg Glu Pro Val Thr Ile Asp Cys Gly 
            20                  25                  30          


His Asn Phe Cys Arg Ala Cys Leu Thr Arg Tyr Cys Glu Ile Pro Gly 
        35                  40                  45              


Pro Asp Leu Glu Glu Ser Pro Thr Cys Pro Leu Cys Lys Glu Pro Phe 
    50                  55                  60                  


Arg Pro Gly Ser Phe Arg Pro Asn Trp Gln Leu Ala Asn Val Val Glu 
65                  70                  75                  80  


Asn Ile Glu Arg Leu Gln Leu Val Ser Thr Leu Gly Leu Gly Glu Glu 
                85                  90                  95      


Asp Val Cys Gln Glu His Gly Glu Lys Ile Tyr Phe Phe Cys Glu Asp 
            100                 105                 110         


Asp Glu Met Gln Leu Cys Val Val Cys Arg Glu Ala Gly Glu His Ala 
        115                 120                 125             


Thr His Thr Met Arg Phe Leu Glu Asp Ala Ala Ala Pro Tyr Arg Glu 
    130                 135                 140                 


Gln Ile His Lys Cys Leu Lys Cys Leu Arg Lys Glu Arg Glu Glu Ile 
145                 150                 155                 160 


Gln Glu Ile Gln Ser Arg Glu Asn Lys Arg Met Gln Val Leu Leu Thr 
                165                 170                 175     


Gln Val Ser Thr Lys Arg Gln Gln Val Ile Ser Glu Phe Ala His Leu 
            180                 185                 190         


Arg Lys Phe Leu Glu Glu Gln Gln Ser Ile Leu Leu Ala Gln Leu Glu 
        195                 200                 205             


Ser Gln Asp Gly Asp Ile Leu Arg Gln Arg Asp Glu Phe Asp Leu Leu 
    210                 215                 220                 


Val Ala Gly Glu Ile Cys Arg Phe Ser Ala Leu Ile Glu Glu Leu Glu 
225                 230                 235                 240 


Glu Lys Asn Glu Arg Pro Ala Arg Glu Leu Leu Thr Asp Ile Arg Ser 
                245                 250                 255     


Thr Leu Ile Arg Cys Glu Thr Arg Lys Cys Arg Lys Pro Val Ala Val 
            260                 265                 270         


Ser Pro Glu Leu Gly Gln Arg Ile Arg Asp Phe Pro Gln Gln Ala Leu 
        275                 280                 285             


Pro Leu Gln Arg Glu Met Lys Met Phe Leu Glu Lys Leu Cys Phe Glu 
    290                 295                 300                 


Leu Asp Tyr Glu Pro Ala His Ile Ser Leu Asp Pro Gln Thr Ser His 
305                 310                 315                 320 


Pro Lys Leu Leu Leu Ser Glu Asp His Gln Arg Ala Gln Phe Ser Tyr 
                325                 330                 335     


Lys Trp Gln Asn Ser Pro Asp Asn Pro Gln Arg Phe Asp Arg Ala Thr 
            340                 345                 350         


Cys Val Leu Ala His Thr Gly Ile Thr Gly Gly Arg His Thr Trp Val 
        355                 360                 365             


Trp Met Ala Arg Val Pro Gly Asp Ser Gly Cys Cys Gln Phe Cys Ser 
    370                 375                 380                 


Pro Pro Ser Val Leu Gly Thr Glu Val Ala Ala 
385                 390                 395 


<210>  3
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Glu Leu Asp Leu Met Ala Pro Gly Pro Leu Pro Arg Ala Thr 
1               5                   10                  15      


Ala Gln Pro Pro Ala Pro Leu Ser Pro Asp Ser Gly Ser Pro Ser Pro 
            20                  25                  30          


Asp Ser Gly Ser Ala Ser Pro Val Glu Glu Glu Asp Val Gly Ser Ser 
        35                  40                  45              


Glu Lys Leu Gly Arg Glu Thr Glu Glu Gln Asp Ser Asp Ser Ala Glu 
    50                  55                  60                  


Gln Gly Asp Pro Ala Gly Glu Gly Lys Glu Val Leu Cys Asp Phe Cys 
65                  70                  75                  80  


Leu Asp Asp Thr Arg Arg Val Lys Ala Val Lys Ser Cys Leu Thr Cys 
                85                  90                  95      


Met Val Asn Tyr Cys Glu Glu His Leu Gln Pro His Gln Val Asn Ile 
            100                 105                 110         


Lys Leu Gln Ser His Leu Leu Thr Glu Pro Val Lys Asp His Asn Trp 
        115                 120                 125             


Arg Tyr Cys Pro Ala His His Ser Pro Leu Ser Ala Phe Cys Cys Pro 
    130                 135                 140                 


Asp Gln Gln Cys Ile Cys Gln Asp Cys Cys Gln Glu His Ser Gly His 
145                 150                 155                 160 


Thr Ile Val Ser Leu Asp Ala Ala Arg Arg Asp Lys Glu Ala Glu Leu 
                165                 170                 175     


Gln Cys Thr Gln Leu Asp Leu Glu Arg Lys Leu Lys Leu Asn Glu Asn 
            180                 185                 190         


Ala Ile Ser Arg Leu Gln Ala Asn Gln Lys Ser Val Leu Val Ser Val 
        195                 200                 205             


Ser Glu Val Lys Ala Val Ala Glu Met Gln Phe Gly Glu Leu Leu Ala 
    210                 215                 220                 


Ala Val Arg Lys Ala Gln Ala Asn Val Met Leu Phe Leu Glu Glu Lys 
225                 230                 235                 240 


Glu Gln Ala Ala Leu Ser Gln Ala Asn Gly Ile Lys Ala His Leu Glu 
                245                 250                 255     


Tyr Arg Ser Ala Glu Met Glu Lys Ser Lys Gln Glu Leu Glu Arg Met 
            260                 265                 270         


Ala Ala Ile Ser Asn Thr Val Gln Phe Leu Glu Glu Tyr Cys Lys Phe 
        275                 280                 285             


Lys Asn Thr Glu Asp Ile Thr Phe Pro Ser Val Tyr Val Gly Leu Lys 
    290                 295                 300                 


Asp Lys Leu Ser Gly Ile Arg Lys Val Ile Thr Glu Ser Thr Val His 
305                 310                 315                 320 


Leu Ile Gln Leu Leu Glu Asn Tyr Lys Lys Lys Leu Gln Glu Phe Ser 
                325                 330                 335     


Lys Glu Glu Glu Tyr Asp Ile Arg Thr Gln Val Ser Ala Val Val Gln 
            340                 345                 350         


Arg Lys Tyr Trp Thr Ser Lys Pro Glu Pro Ser Thr Arg Glu Gln Phe 
        355                 360                 365             


Leu Gln Tyr Ala Tyr Asp Ile Thr Phe Asp Pro Asp Thr Ala His Lys 
    370                 375                 380                 


Tyr Leu Arg Leu Gln Glu Glu Asn Arg Lys Val Thr Asn Thr Thr Pro 
385                 390                 395                 400 


Trp Glu His Pro Tyr Pro Asp Leu Pro Ser Arg Phe Leu His Trp Arg 
                405                 410                 415     


Gln Val Leu Ser Gln Gln Ser Leu Tyr Leu His Arg Tyr Tyr Phe Glu 
            420                 425                 430         


Val Glu Ile Phe Gly Ala Gly Thr Tyr Val Gly Leu Thr Cys Lys Gly 
        435                 440                 445             


Ile Asp Arg Lys Gly Glu Glu Arg Asn Ser Cys Ile Ser Gly Asn Asn 
    450                 455                 460                 


Phe Ser Trp Ser Leu Gln Trp Asn Gly Lys Glu Phe Thr Ala Trp Tyr 
465                 470                 475                 480 


Ser Asp Met Glu Thr Pro Leu Lys Ala Gly Pro Phe Arg Arg Leu Gly 
                485                 490                 495     


Val Tyr Ile Asp Phe Pro Gly Gly Ile Leu Ser Phe Tyr Gly Val Glu 
            500                 505                 510         


Tyr Asp Thr Met Thr Leu Val His Lys Phe Ala Cys Lys Phe Ser Glu 
        515                 520                 525             


Pro Val Tyr Ala Ala Phe Trp Leu Ser Lys Lys Glu Asn Ala Ile Arg 
    530                 535                 540                 


Ile Val Asp Leu Gly Glu Glu Pro Glu Lys Pro Ala Pro Ser Leu Val 
545                 550                 555                 560 


Gly Thr Ala Pro 
                


<210>  4
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Pro Ala Pro Ala Arg Ser Pro Arg Pro Gln Gln Asp Pro Ala 
1               5                   10                  15      


Arg Pro Gln Glu Pro Thr Met Pro Pro Pro Glu Thr Pro Ser Glu Gly 
            20                  25                  30          


Arg Gln Pro Ser Pro Ser Pro Ser Pro Thr Glu Arg Ala Pro Ala Ser 
        35                  40                  45              


Glu Glu Glu Phe Gln Phe Leu Arg Cys Gln Gln Cys Gln Ala Glu Ala 
    50                  55                  60                  


Lys Cys Pro Lys Leu Leu Pro Cys Leu His Thr Leu Cys Ser Gly Cys 
65                  70                  75                  80  


Leu Glu Ala Ser Gly Met Gln Cys Pro Ile Cys Gln Ala Pro Trp Pro 
                85                  90                  95      


Leu Gly Ala Asp Thr Pro Ala Leu Asp Asn Val Phe Phe Glu Ser Leu 
            100                 105                 110         


Gln Arg Arg Leu Ser Val Tyr Arg Gln Ile Val Asp Ala Gln Ala Val 
        115                 120                 125             


Cys Thr Arg Cys Lys Glu Ser Ala Asp Phe Trp Cys Phe Glu Cys Glu 
    130                 135                 140                 


Gln Leu Leu Cys Ala Lys Cys Phe Glu Ala His Gln Trp Phe Leu Lys 
145                 150                 155                 160 


His Glu Ala Arg Pro Leu Ala Glu Leu Arg Asn Gln Ser Val Arg Glu 
                165                 170                 175     


Phe Leu Asp Gly Thr Arg Lys Thr Asn Asn Ile Phe Cys Ser Asn Pro 
            180                 185                 190         


Asn His Arg Thr Pro Thr Leu Thr Ser Ile Tyr Cys Arg Gly Cys Ser 
        195                 200                 205             


Lys Pro Leu Cys Cys Ser Cys Ala Leu Leu Asp Ser Ser His Ser Glu 
    210                 215                 220                 


Leu Lys Cys Asp Ile Ser Ala Glu Ile Gln Gln Arg Gln Glu Glu Leu 
225                 230                 235                 240 


Asp Ala Met Thr Gln Ala Leu Gln Glu Gln Asp Ser Ala Phe Gly Ala 
                245                 250                 255     


Val His Ala Gln Met His Ala Ala Val Gly Gln Leu Gly Arg Ala Arg 
            260                 265                 270         


Ala Glu Thr Glu Glu Leu Ile Arg Glu Arg Val Arg Gln Val Val Ala 
        275                 280                 285             


His Val Arg Ala Gln Glu Arg Glu Leu Leu Glu Ala Val Asp Ala Arg 
    290                 295                 300                 


Tyr Gln Arg Asp Tyr Glu Glu Met Ala Ser Arg Leu Gly Arg Leu Asp 
305                 310                 315                 320 


Ala Val Leu Gln Arg Ile Arg Thr Gly Ser Ala Leu Val Gln Arg Met 
                325                 330                 335     


Lys Cys Tyr Ala Ser Asp Gln Glu Val Leu Asp Met His Gly Phe Leu 
            340                 345                 350         


Arg Gln Ala Leu Cys Arg Leu Arg Gln Glu Glu Pro Gln Ser Leu Gln 
        355                 360                 365             


Ala Ala Val Arg Thr Asp Gly Phe Asp Glu Phe Lys Val Arg Leu Gln 
    370                 375                 380                 


Asp Leu Ser Ser Cys Ile Thr Gln Gly Lys Asp Ala Ala Val Ser Lys 
385                 390                 395                 400 


Lys Ala Ser Pro Glu Ala Ala Ser Thr Pro Arg Asp Pro Ile Asp Val 
                405                 410                 415     


Asp Leu Leu Pro Pro Pro Ala His Ala Leu Thr Gly Pro Ala Gln Ser 
            420                 425                 430         


Ser Thr His 
        435 


<210>  5
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asn Ser Gly Ile Leu Gln Val Phe Gln Arg Ala Leu Thr Cys Pro 
1               5                   10                  15      


Ile Cys Met Asn Tyr Phe Leu Asp Pro Val Thr Ile Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Arg Pro Cys Leu Tyr Leu Asn Trp Gln Asp Thr Ala Val 
        35                  40                  45              


Leu Ala Gln Cys Ser Glu Cys Lys Lys Thr Thr Arg Gln Arg Asn Leu 
    50                  55                  60                  


Asn Thr Asp Ile Cys Leu Lys Asn Met Ala Phe Ile Ala Arg Lys Ala 
65                  70                  75                  80  


Ser Leu Arg Gln Phe Leu Ser Ser Glu Glu Gln Ile Cys Gly Met His 
                85                  90                  95      


Arg Glu Thr Lys Lys Met Phe Cys Glu Val Asp Lys Ser Leu Leu Cys 
            100                 105                 110         


Leu Pro Cys Ser Asn Ser Gln Glu His Arg Asn His Ile His Cys Pro 
        115                 120                 125             


Ile Glu Trp Ala Ala Glu Glu Arg Arg Glu Glu Leu Leu Lys Lys Met 
    130                 135                 140                 


Gln Ser Leu Trp Glu Lys Ala Cys Glu Asn Leu Arg Asn Leu Asn Met 
145                 150                 155                 160 


Glu Thr Thr Arg Thr Arg Cys Trp Lys Asp Tyr Val Ser Leu Arg Ile 
                165                 170                 175     


Glu Ala Ile Arg Ala Glu Tyr Gln Lys Met Pro Ala Phe Leu His Glu 
            180                 185                 190         


Glu Glu Gln His His Leu Glu Arg Leu Arg Lys Glu Gly Glu Asp Ile 
        195                 200                 205             


Phe Gln Gln Leu Asn Glu Ser Lys Ala Arg Met Glu His Ser Arg Glu 
    210                 215                 220                 


Leu Leu Arg Gly Met Tyr Glu Asp Leu Lys Gln Met Cys His Lys Ala 
225                 230                 235                 240 


Asp Val Glu Leu Leu Gln Ala Phe Gly Asp Ile Leu His Arg Tyr Glu 
                245                 250                 255     


Ser Leu Leu Leu Gln Val Ser Glu Pro Val Asn Pro Glu Leu Ser Ala 
            260                 265                 270         


Gly Pro Ile Thr Gly Leu Leu Asp Ser Leu Ser Gly Phe Arg Val Asp 
        275                 280                 285             


Phe Thr Leu Gln Pro Glu Arg Ala Asn Ser His Ile Phe Leu Cys Gly 
    290                 295                 300                 


Asp Leu Arg Ser Met Asn Val Gly Cys Asp Pro Gln Asp Asp Pro Asp 
305                 310                 315                 320 


Ile Thr Gly Lys Ser Glu Cys Phe Leu Val Trp Gly Ala Gln Ala Phe 
                325                 330                 335     


Thr Ser Gly Lys Tyr Tyr Trp Glu Val His Met Gly Asp Ser Trp Asn 
            340                 345                 350         


Trp Ala Phe Gly Val Cys Asn Asn Tyr Trp Lys Glu Lys Arg Gln Asn 
        355                 360                 365             


Asp Lys Ile Asp Gly Glu Glu Gly Leu Phe Leu Leu Gly Cys Val Lys 
    370                 375                 380                 


Glu Asp Thr His Cys Ser Leu Phe Thr Thr Ser Pro Leu Val Val Gln 
385                 390                 395                 400 


Tyr Val Pro Arg Pro Thr Ser Thr Val Gly Leu Phe Leu Asp Cys Glu 
                405                 410                 415     


Gly Arg Thr Val Ser Phe Val Asp Val Asp Gln Ser Ser Leu Ile Tyr 
            420                 425                 430         


Thr Ile Pro Asn Cys Ser Phe Ser Pro Pro Leu Arg Pro Ile Phe Cys 
        435                 440                 445             


Cys Ser His Phe 
    450         


<210>  6
<211>  735
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Glu Ser Pro Ala Ser Val Val Leu Asn Ala Ser Gly Gly Leu 
1               5                   10                  15      


Phe Ser Leu Lys Met Glu Thr Leu Glu Ser Glu Leu Thr Cys Pro Ile 
            20                  25                  30          


Cys Leu Glu Leu Phe Glu Asp Pro Leu Leu Leu Pro Cys Ala His Ser 
        35                  40                  45              


Leu Cys Phe Ser Cys Ala His Arg Ile Leu Val Ser Ser Cys Ser Ser 
    50                  55                  60                  


Gly Glu Ser Ile Glu Pro Ile Thr Ala Phe Gln Cys Pro Thr Cys Arg 
65                  70                  75                  80  


Tyr Val Ile Ser Leu Asn His Arg Gly Leu Asp Gly Leu Lys Arg Asn 
                85                  90                  95      


Val Thr Leu Gln Asn Ile Ile Asp Arg Phe Gln Lys Ala Ser Val Ser 
            100                 105                 110         


Gly Pro Asn Ser Pro Ser Glu Ser Arg Arg Glu Arg Thr Tyr Arg Pro 
        115                 120                 125             


Thr Thr Ala Met Ser Ser Glu Arg Ile Ala Cys Gln Phe Cys Glu Gln 
    130                 135                 140                 


Asp Pro Pro Arg Asp Ala Val Lys Thr Cys Ile Thr Cys Glu Val Ser 
145                 150                 155                 160 


Tyr Cys Asp Arg Cys Leu Arg Ala Thr His Pro Asn Lys Lys Pro Phe 
                165                 170                 175     


Thr Ser His Arg Leu Val Glu Pro Val Pro Asp Thr His Leu Arg Gly 
            180                 185                 190         


Ile Thr Cys Leu Asp His Glu Asn Glu Lys Val Asn Met Tyr Cys Val 
        195                 200                 205             


Ser Asp Asp Gln Leu Ile Cys Ala Leu Cys Lys Leu Val Gly Arg His 
    210                 215                 220                 


Arg Asp His Gln Val Ala Ser Leu Asn Asp Arg Phe Glu Lys Leu Lys 
225                 230                 235                 240 


Gln Thr Leu Glu Met Asn Leu Thr Asn Leu Val Lys Arg Asn Ser Glu 
                245                 250                 255     


Leu Glu Asn Gln Met Ala Lys Leu Ile Gln Ile Cys Gln Gln Val Glu 
            260                 265                 270         


Val Asn Thr Ala Met His Glu Ala Lys Leu Met Glu Glu Cys Asp Glu 
        275                 280                 285             


Leu Val Glu Ile Ile Gln Gln Arg Lys Gln Met Ile Ala Val Lys Ile 
    290                 295                 300                 


Lys Glu Thr Lys Val Met Lys Leu Arg Lys Leu Ala Gln Gln Val Ala 
305                 310                 315                 320 


Asn Cys Arg Gln Cys Leu Glu Arg Ser Thr Val Leu Ile Asn Gln Ala 
                325                 330                 335     


Glu His Ile Leu Lys Glu Asn Asp Gln Ala Arg Phe Leu Gln Ser Ala 
            340                 345                 350         


Lys Asn Ile Ala Glu Arg Val Ala Met Ala Thr Ala Ser Ser Gln Val 
        355                 360                 365             


Leu Ile Pro Asp Ile Asn Phe Asn Asp Ala Phe Glu Asn Phe Ala Leu 
    370                 375                 380                 


Asp Phe Ser Arg Glu Lys Lys Leu Leu Glu Gly Leu Asp Tyr Leu Thr 
385                 390                 395                 400 


Ala Pro Asn Pro Pro Ser Ile Arg Glu Glu Leu Cys Thr Ala Ser His 
                405                 410                 415     


Asp Thr Ile Thr Val His Trp Ile Ser Asp Asp Glu Phe Ser Ile Ser 
            420                 425                 430         


Ser Tyr Glu Leu Gln Tyr Thr Ile Phe Thr Gly Gln Ala Asn Phe Ile 
        435                 440                 445             


Ser Lys Ser Trp Cys Ser Trp Gly Leu Trp Pro Glu Ile Arg Lys Cys 
    450                 455                 460                 


Lys Glu Ala Val Ser Cys Ser Arg Leu Ala Gly Ala Pro Arg Gly Leu 
465                 470                 475                 480 


Tyr Asn Ser Val Asp Ser Trp Met Ile Val Pro Asn Ile Lys Gln Asn 
                485                 490                 495     


His Tyr Thr Val His Gly Leu Gln Ser Gly Thr Arg Tyr Ile Phe Ile 
            500                 505                 510         


Val Lys Ala Ile Asn Gln Ala Gly Ser Arg Asn Ser Glu Pro Thr Arg 
        515                 520                 525             


Leu Lys Thr Asn Ser Gln Pro Phe Lys Leu Asp Pro Lys Met Thr His 
    530                 535                 540                 


Lys Lys Leu Lys Ile Ser Asn Asp Gly Leu Gln Met Glu Lys Asp Glu 
545                 550                 555                 560 


Ser Ser Leu Lys Lys Ser His Thr Pro Glu Arg Phe Ser Gly Thr Gly 
                565                 570                 575     


Cys Tyr Gly Ala Ala Gly Asn Ile Phe Ile Asp Ser Gly Cys His Tyr 
            580                 585                 590         


Trp Glu Val Val Met Gly Ser Ser Thr Trp Tyr Ala Ile Gly Ile Ala 
        595                 600                 605             


Tyr Lys Ser Ala Pro Lys Asn Glu Trp Ile Gly Lys Asn Ala Ser Ser 
    610                 615                 620                 


Trp Val Phe Ser Arg Cys Asn Ser Asn Phe Val Val Arg His Asn Asn 
625                 630                 635                 640 


Lys Glu Met Leu Val Asp Val Pro Pro His Leu Lys Arg Leu Gly Val 
                645                 650                 655     


Leu Leu Asp Tyr Asp Asn Asn Met Leu Ser Phe Tyr Asp Pro Ala Asn 
            660                 665                 670         


Ser Leu His Leu His Thr Phe Asp Val Thr Phe Ile Leu Pro Val Cys 
        675                 680                 685             


Pro Thr Phe Thr Ile Trp Asn Lys Ser Leu Met Ile Leu Ser Gly Leu 
    690                 695                 700                 


Pro Ala Pro Asp Phe Ile Asp Tyr Pro Glu Arg Gln Glu Cys Asn Cys 
705                 710                 715                 720 


Arg Pro Gln Glu Ser Pro Tyr Val Ser Gly Met Lys Thr Cys His 
                725                 730                 735 


<210>  7
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Lys Thr Pro Ser Asp His Leu Leu Ser Thr Leu Glu Glu Leu 
1               5                   10                  15      


Val Pro Tyr Asp Phe Glu Lys Phe Lys Phe Lys Leu Gln Asn Thr Ser 
            20                  25                  30          


Val Gln Lys Glu His Ser Arg Ile Pro Arg Ser Gln Ile Gln Arg Ala 
        35                  40                  45              


Arg Pro Val Lys Met Ala Thr Leu Leu Val Thr Tyr Tyr Gly Glu Glu 
    50                  55                  60                  


Tyr Ala Val Gln Leu Thr Leu Gln Val Leu Arg Ala Ile Asn Gln Arg 
65                  70                  75                  80  


Leu Leu Ala Glu Glu Leu His Arg Ala Ala Ile Gln Glu Tyr Ser Thr 
                85                  90                  95      


Gln Glu Asn Gly Thr Asp Asp Ser Ala Ala Ser Ser Ser Leu Gly Glu 
            100                 105                 110         


Asn Lys Pro Arg Ser Leu Lys Thr Pro Asp His Pro Glu Gly Asn Glu 
        115                 120                 125             


Gly Asn Gly Pro Arg Pro Tyr Gly Gly Gly Ala Ala Ser Leu Arg Cys 
    130                 135                 140                 


Ser Gln Pro Glu Ala Gly Arg Gly Leu Ser Arg Lys Pro Leu Ser Lys 
145                 150                 155                 160 


Arg Arg Glu Lys Ala Ser Glu Gly Leu Asp Ala Gln Gly Lys Pro Arg 
                165                 170                 175     


Thr Arg Ser Pro Ala Leu Pro Gly Gly Arg Ser Pro Gly Pro Cys Arg 
            180                 185                 190         


Ala Leu Glu Gly Gly Gln Ala Glu Val Arg Leu Arg Arg Asn Ala Ser 
        195                 200                 205             


Ser Ala Gly Arg Leu Gln Gly Leu Ala Gly Gly Ala Pro Gly Gln Lys 
    210                 215                 220                 


Glu Cys Arg Pro Phe Glu Val Tyr Leu Pro Ser Gly Lys Met Arg Pro 
225                 230                 235                 240 


Arg Ser Leu Glu Val Thr Ile Ser Thr Gly Glu Lys Ala Pro Ala Asn 
                245                 250                 255     


Pro Glu Ile Leu Leu Thr Leu Glu Glu Lys Thr Ala Ala Asn Leu Asp 
            260                 265                 270         


Ser Ala Thr Glu Pro Arg Ala Arg Pro Thr Pro Asp Gly Gly Ala Ser 
        275                 280                 285             


Ala Asp Leu Lys Glu Gly Pro Gly Asn Pro Glu His Ser Val Thr Gly 
    290                 295                 300                 


Arg Pro Pro Asp Thr Ala Ala Ser Pro Arg Cys His Ala Gln Glu Gly 
305                 310                 315                 320 


Asp Pro Val Asp Gly Thr Cys Val Arg Asp Ser Cys Ser Phe Pro Glu 
                325                 330                 335     


Ala Val Ser Gly His Pro Gln Ala Ser Gly Ser Arg Ser Pro Gly Cys 
            340                 345                 350         


Pro Arg Cys Gln Asp Ser His Glu Arg Lys Ser Pro Gly Ser Leu Ser 
        355                 360                 365             


Pro Gln Pro Leu Pro Gln Cys Lys Arg His Leu Lys Gln Val Gln Leu 
    370                 375                 380                 


Leu Phe Cys Glu Asp His Asp Glu Pro Ile Cys Leu Ile Cys Ser Leu 
385                 390                 395                 400 


Ser Gln Glu His Gln Gly His Arg Val Arg Pro Ile Glu Glu Val Ala 
                405                 410                 415     


Leu Glu His Lys Lys Lys Ile Gln Lys Gln Leu Glu His Leu Lys Lys 
            420                 425                 430         


Leu Arg Lys Ser Gly Glu Glu Gln Arg Ser Tyr Gly Glu Glu Lys Ala 
        435                 440                 445             


Val Ser Phe Leu Lys Gln Thr Glu Ala Leu Lys Gln Arg Val Gln Arg 
    450                 455                 460                 


Lys Leu Glu Gln Val Tyr Tyr Phe Leu Glu Gln Gln Glu His Phe Phe 
465                 470                 475                 480 


Val Ala Ser Leu Glu Asp Val Gly Gln Met Val Gly Gln Ile Arg Lys 
                485                 490                 495     


Ala Tyr Asp Thr Arg Val Ser Gln Asp Ile Ala Leu Leu Asp Ala Leu 
            500                 505                 510         


Ile Gly Glu Leu Glu Ala Lys Glu Cys Gln Ser Glu Trp Glu Leu Leu 
        515                 520                 525             


Gln Asp Ile Gly Asp Ile Leu His Arg Ala Lys Thr Val Pro Val Pro 
    530                 535                 540                 


Glu Lys Trp Thr Thr Pro Gln Glu Ile Lys Gln Lys Ile Gln Leu Leu 
545                 550                 555                 560 


His Gln Lys Ser Glu Phe Val Glu Lys Ser Thr Lys Tyr Phe Ser Glu 
                565                 570                 575     


Thr Leu Arg Ser Glu Met Glu Met Phe Asn Val Pro Glu Leu Ile Gly 
            580                 585                 590         


Ala Gln Ala His Ala Val Asn Val Ile Leu Asp Ala Glu Thr Ala Tyr 
        595                 600                 605             


Pro Asn Leu Ile Phe Ser Asp Asp Leu Lys Ser Val Arg Leu Gly Asn 
    610                 615                 620                 


Lys Trp Glu Arg Leu Pro Asp Gly Pro Gln Arg Phe Asp Ser Cys Ile 
625                 630                 635                 640 


Ile Val Leu Gly Ser Pro Ser Phe Leu Ser Gly Arg Arg Tyr Trp Glu 
                645                 650                 655     


Val Glu Val Gly Asp Lys Thr Ala Trp Ile Leu Gly Ala Cys Lys Thr 
            660                 665                 670         


Ser Ile Ser Arg Lys Gly Asn Met Thr Leu Ser Pro Glu Asn Gly Tyr 
        675                 680                 685             


Trp Val Val Ile Met Met Lys Glu Asn Glu Tyr Gln Ala Ser Ser Val 
    690                 695                 700                 


Pro Pro Thr Arg Leu Leu Ile Lys Glu Pro Pro Lys Arg Val Gly Ile 
705                 710                 715                 720 


Phe Val Asp Tyr Arg Val Gly Ser Ile Ser Phe Tyr Asn Val Thr Ala 
                725                 730                 735     


Arg Ser His Ile Tyr Thr Phe Ala Ser Cys Ser Phe Ser Gly Pro Leu 
            740                 745                 750         


Gln Pro Ile Phe Ser Pro Gly Thr Arg Asp Gly Gly Lys Asn Thr Ala 
        755                 760                 765             


Pro Leu Thr Ile Cys Pro Val Gly Gly Gln Gly Pro Asp 
    770                 775                 780     


<210>  8
<211>  475
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ser Ala Ala Arg Leu Thr Met Met Trp Glu Glu Val Thr Cys 
1               5                   10                  15      


Pro Ile Cys Leu Asp Pro Phe Val Glu Pro Val Ser Ile Glu Cys Gly 
            20                  25                  30          


His Ser Phe Cys Gln Glu Cys Ile Ser Gln Val Gly Lys Gly Gly Gly 
        35                  40                  45              


Ser Val Cys Pro Val Cys Arg Gln Arg Phe Leu Leu Lys Asn Leu Arg 
    50                  55                  60                  


Pro Asn Arg Gln Leu Ala Asn Met Val Asn Asn Leu Lys Glu Ile Ser 
65                  70                  75                  80  


Gln Glu Ala Arg Glu Gly Thr Gln Gly Glu Arg Cys Ala Val His Gly 
                85                  90                  95      


Glu Arg Leu His Leu Phe Cys Glu Lys Asp Gly Lys Ala Leu Cys Trp 
            100                 105                 110         


Val Cys Ala Gln Ser Arg Lys His Arg Asp His Ala Met Val Pro Leu 
        115                 120                 125             


Glu Glu Ala Ala Gln Glu Tyr Gln Glu Lys Leu Gln Val Ala Leu Gly 
    130                 135                 140                 


Glu Leu Arg Arg Lys Gln Glu Leu Ala Glu Lys Leu Glu Val Glu Ile 
145                 150                 155                 160 


Ala Ile Lys Arg Ala Asp Trp Lys Lys Thr Val Glu Thr Gln Lys Ser 
                165                 170                 175     


Arg Ile His Ala Glu Phe Val Gln Gln Lys Asn Phe Leu Val Glu Glu 
            180                 185                 190         


Glu Gln Arg Gln Leu Gln Glu Leu Glu Lys Asp Glu Arg Glu Gln Leu 
        195                 200                 205             


Arg Ile Leu Gly Glu Lys Glu Ala Lys Leu Ala Gln Gln Ser Gln Ala 
    210                 215                 220                 


Leu Gln Glu Leu Ile Ser Glu Leu Asp Arg Arg Cys His Ser Ser Ala 
225                 230                 235                 240 


Leu Glu Leu Leu Gln Glu Val Ile Ile Val Leu Glu Arg Ser Glu Ser 
                245                 250                 255     


Trp Asn Leu Lys Asp Leu Asp Ile Thr Ser Pro Glu Leu Arg Ser Val 
            260                 265                 270         


Cys His Val Pro Gly Leu Lys Lys Met Leu Arg Thr Cys Ala Val His 
        275                 280                 285             


Ile Thr Leu Asp Pro Asp Thr Ala Asn Pro Trp Leu Ile Leu Ser Glu 
    290                 295                 300                 


Asp Arg Arg Gln Val Arg Leu Gly Asp Thr Gln Gln Ser Ile Pro Gly 
305                 310                 315                 320 


Asn Glu Glu Arg Phe Asp Ser Tyr Pro Met Val Leu Gly Ala Gln His 
                325                 330                 335     


Phe His Ser Gly Lys His Tyr Trp Glu Val Asp Val Thr Gly Lys Glu 
            340                 345                 350         


Ala Trp Asp Leu Gly Val Cys Arg Asp Ser Val Arg Arg Lys Gly His 
        355                 360                 365             


Phe Leu Leu Ser Ser Lys Ser Gly Phe Trp Thr Ile Trp Leu Trp Asn 
    370                 375                 380                 


Lys Gln Lys Tyr Glu Ala Gly Thr Tyr Pro Gln Thr Pro Leu His Leu 
385                 390                 395                 400 


Gln Val Pro Pro Cys Gln Val Gly Ile Phe Leu Asp Tyr Glu Ala Gly 
                405                 410                 415     


Met Val Ser Phe Tyr Asn Ile Thr Asp His Gly Ser Leu Ile Tyr Ser 
            420                 425                 430         


Phe Ser Glu Cys Ala Phe Thr Gly Pro Leu Arg Pro Phe Phe Ser Pro 
        435                 440                 445             


Gly Phe Asn Asp Gly Gly Lys Asn Thr Ala Pro Leu Thr Leu Cys Pro 
    450                 455                 460                 


Leu Asn Ile Gly Ser Gln Gly Ser Thr Asp Tyr 
465                 470                 475 


<210>  9
<211>  498
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Asp Phe Ser Val Lys Val Asp Ile Glu Lys Glu Val Thr Cys Pro 
1               5                   10                  15      


Ile Cys Leu Glu Leu Leu Thr Glu Pro Leu Ser Leu Asp Cys Gly His 
            20                  25                  30          


Ser Phe Cys Gln Ala Cys Ile Thr Ala Lys Ile Lys Glu Ser Val Ile 
        35                  40                  45              


Ile Ser Arg Gly Glu Ser Ser Cys Pro Val Cys Gln Thr Arg Phe Gln 
    50                  55                  60                  


Pro Gly Asn Leu Arg Pro Asn Arg His Leu Ala Asn Ile Val Glu Arg 
65                  70                  75                  80  


Val Lys Glu Val Lys Met Ser Pro Gln Glu Gly Gln Lys Arg Asp Val 
                85                  90                  95      


Cys Glu His His Gly Lys Lys Leu Gln Ile Phe Cys Lys Glu Asp Gly 
            100                 105                 110         


Lys Val Ile Cys Trp Val Cys Glu Leu Ser Gln Glu His Gln Gly His 
        115                 120                 125             


Gln Thr Phe Arg Ile Asn Glu Val Val Lys Glu Cys Gln Glu Lys Leu 
    130                 135                 140                 


Gln Val Ala Leu Gln Arg Leu Ile Lys Glu Asp Gln Glu Ala Glu Lys 
145                 150                 155                 160 


Leu Glu Asp Asp Ile Arg Gln Glu Arg Thr Ala Trp Lys Asn Tyr Ile 
                165                 170                 175     


Gln Ile Glu Arg Gln Lys Ile Leu Lys Gly Phe Asn Glu Met Arg Val 
            180                 185                 190         


Ile Leu Asp Asn Glu Glu Gln Arg Glu Leu Gln Lys Leu Glu Glu Gly 
        195                 200                 205             


Glu Val Asn Val Leu Asp Asn Leu Ala Ala Ala Thr Asp Gln Leu Val 
    210                 215                 220                 


Gln Gln Arg Gln Asp Ala Ser Thr Leu Ile Ser Asp Leu Gln Arg Arg 
225                 230                 235                 240 


Leu Arg Gly Ser Ser Val Glu Met Leu Gln Asp Val Ile Asp Val Met 
                245                 250                 255     


Lys Arg Ser Glu Ser Trp Thr Leu Lys Lys Pro Lys Ser Val Ser Lys 
            260                 265                 270         


Lys Leu Lys Ser Val Phe Arg Val Pro Asp Leu Ser Gly Met Leu Gln 
        275                 280                 285             


Val Leu Lys Glu Leu Thr Asp Val Gln Tyr Tyr Trp Val Asp Val Met 
    290                 295                 300                 


Leu Asn Pro Gly Ser Ala Thr Ser Asn Val Ala Ile Ser Val Asp Gln 
305                 310                 315                 320 


Arg Gln Val Lys Thr Val Arg Thr Cys Thr Phe Lys Asn Ser Asn Pro 
                325                 330                 335     


Cys Asp Phe Ser Ala Phe Gly Val Phe Gly Cys Gln Tyr Phe Ser Ser 
            340                 345                 350         


Gly Lys Tyr Tyr Trp Glu Val Asp Val Ser Gly Lys Ile Ala Trp Ile 
        355                 360                 365             


Leu Gly Val His Ser Lys Ile Ser Ser Leu Asn Lys Arg Lys Ser Ser 
    370                 375                 380                 


Gly Phe Ala Phe Asp Pro Ser Val Asn Tyr Ser Lys Val Tyr Ser Arg 
385                 390                 395                 400 


Tyr Arg Pro Gln Tyr Gly Tyr Trp Val Ile Gly Leu Gln Asn Thr Cys 
                405                 410                 415     


Glu Tyr Asn Ala Phe Glu Asp Ser Ser Ser Ser Asp Pro Lys Val Leu 
            420                 425                 430         


Thr Leu Phe Met Ala Val Pro Pro Cys Arg Ile Gly Val Phe Leu Asp 
        435                 440                 445             


Tyr Glu Ala Gly Ile Val Ser Phe Phe Asn Val Thr Asn His Gly Ala 
    450                 455                 460                 


Leu Ile Tyr Lys Phe Ser Gly Cys Arg Phe Ser Arg Pro Ala Tyr Pro 
465                 470                 475                 480 


Tyr Phe Asn Pro Trp Asn Cys Leu Val Pro Met Thr Val Cys Pro Pro 
                485                 490                 495     


Ser Ser 
        


<210>  10
<211>  755
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Val Ser His Gly Ser Ser Pro Ser Leu Leu Glu Ala Leu Ser Ser 
1               5                   10                  15      


Asp Phe Leu Ala Cys Lys Ile Cys Leu Glu Gln Leu Arg Ala Pro Lys 
            20                  25                  30          


Thr Leu Pro Cys Leu His Thr Tyr Cys Gln Asp Cys Leu Ala Gln Leu 
        35                  40                  45              


Ala Asp Gly Gly Arg Val Arg Cys Pro Glu Cys Arg Glu Thr Val Pro 
    50                  55                  60                  


Val Pro Pro Glu Gly Val Ala Ser Phe Lys Thr Asn Phe Phe Val Asn 
65                  70                  75                  80  


Gly Leu Leu Asp Leu Val Lys Ala Arg Ala Cys Gly Asp Leu Arg Ala 
                85                  90                  95      


Gly Lys Pro Ala Cys Ala Leu Cys Pro Leu Val Gly Gly Thr Ser Thr 
            100                 105                 110         


Gly Gly Pro Ala Thr Ala Arg Cys Leu Asp Cys Ala Asp Asp Leu Cys 
        115                 120                 125             


Gln Ala Cys Ala Asp Gly His Arg Cys Thr Arg Gln Thr His Thr His 
    130                 135                 140                 


Arg Val Val Asp Leu Val Gly Tyr Arg Ala Gly Trp Tyr Asp Glu Glu 
145                 150                 155                 160 


Ala Arg Glu Arg Gln Ala Ala Gln Cys Pro Gln His Pro Gly Glu Ala 
                165                 170                 175     


Leu Arg Phe Leu Cys Gln Pro Cys Ser Gln Leu Leu Cys Arg Glu Cys 
            180                 185                 190         


Arg Leu Asp Pro His Leu Asp His Pro Cys Leu Pro Leu Ala Glu Ala 
        195                 200                 205             


Val Arg Ala Arg Arg Pro Gly Leu Glu Gly Leu Leu Ala Gly Val Asp 
    210                 215                 220                 


Asn Asn Leu Val Glu Leu Glu Ala Ala Arg Arg Val Glu Lys Glu Ala 
225                 230                 235                 240 


Leu Ala Arg Leu Arg Glu Gln Ala Ala Arg Val Gly Thr Gln Val Glu 
                245                 250                 255     


Glu Ala Ala Glu Gly Val Leu Arg Ala Leu Leu Ala Gln Lys Gln Glu 
            260                 265                 270         


Val Leu Gly Gln Leu Arg Ala His Val Glu Ala Ala Glu Glu Ala Ala 
        275                 280                 285             


Arg Glu Arg Leu Ala Glu Leu Glu Gly Arg Glu Gln Val Ala Arg Ala 
    290                 295                 300                 


Ala Ala Ala Phe Ala Arg Arg Val Leu Ser Leu Gly Arg Glu Ala Glu 
305                 310                 315                 320 


Ile Leu Ser Leu Glu Gly Ala Ile Ala Gln Arg Leu Arg Gln Leu Gln 
                325                 330                 335     


Gly Cys Pro Trp Ala Pro Gly Pro Ala Pro Cys Leu Leu Pro Gln Leu 
            340                 345                 350         


Glu Leu His Pro Gly Leu Leu Asp Lys Asn Cys His Leu Leu Arg Leu 
        355                 360                 365             


Ser Phe Glu Glu Gln Gln Pro Gln Lys Asp Gly Gly Lys Asp Gly Ala 
    370                 375                 380                 


Gly Thr Gln Gly Gly Glu Glu Ser Gln Ser Arg Arg Glu Asp Glu Pro 
385                 390                 395                 400 


Lys Thr Glu Arg Gln Gly Gly Val Gln Pro Gln Ala Gly Asp Gly Ala 
                405                 410                 415     


Gln Thr Pro Lys Glu Glu Lys Ala Gln Thr Thr Arg Glu Glu Gly Ala 
            420                 425                 430         


Gln Thr Leu Glu Glu Asp Arg Ala Gln Thr Pro His Glu Asp Gly Gly 
        435                 440                 445             


Pro Gln Pro His Arg Gly Gly Arg Pro Asn Lys Lys Lys Lys Phe Lys 
    450                 455                 460                 


Gly Arg Leu Lys Ser Ile Ser Arg Glu Pro Ser Pro Ala Leu Gly Pro 
465                 470                 475                 480 


Asn Leu Asp Gly Ser Gly Leu Leu Pro Arg Pro Ile Phe Tyr Cys Ser 
                485                 490                 495     


Phe Pro Thr Arg Met Pro Gly Asp Lys Arg Ser Pro Arg Ile Thr Gly 
            500                 505                 510         


Leu Cys Pro Phe Gly Pro Arg Glu Ile Leu Val Ala Asp Glu Gln Asn 
        515                 520                 525             


Arg Ala Leu Lys Arg Phe Ser Leu Asn Gly Asp Tyr Lys Gly Thr Val 
    530                 535                 540                 


Pro Val Pro Glu Gly Cys Ser Pro Cys Ser Val Ala Ala Leu Gln Ser 
545                 550                 555                 560 


Ala Val Ala Phe Ser Ala Ser Ala Arg Leu Tyr Leu Ile Asn Pro Asn 
                565                 570                 575     


Gly Glu Val Gln Trp Arg Arg Ala Leu Ser Leu Ser Gln Ala Ser His 
            580                 585                 590         


Ala Val Ala Ala Leu Pro Ser Gly Asp Arg Val Ala Val Ser Val Ala 
        595                 600                 605             


Gly His Val Glu Val Tyr Asn Met Glu Gly Ser Leu Ala Thr Arg Phe 
    610                 615                 620                 


Ile Pro Gly Gly Lys Ala Ser Arg Gly Leu Arg Ala Leu Val Phe Leu 
625                 630                 635                 640 


Thr Thr Ser Pro Gln Gly His Phe Val Gly Ser Asp Trp Gln Gln Asn 
                645                 650                 655     


Ser Val Val Ile Cys Asp Gly Leu Gly Gln Val Val Gly Glu Tyr Lys 
            660                 665                 670         


Gly Pro Gly Leu His Gly Cys Gln Pro Gly Ser Val Ser Val Asp Lys 
        675                 680                 685             


Lys Gly Tyr Ile Phe Leu Thr Leu Arg Glu Val Asn Lys Val Val Ile 
    690                 695                 700                 


Leu Asp Pro Lys Gly Ser Leu Leu Gly Asp Phe Leu Thr Ala Tyr His 
705                 710                 715                 720 


Gly Leu Glu Lys Pro Arg Val Thr Thr Met Val Asp Gly Arg Tyr Leu 
                725                 730                 735     


Val Val Ser Leu Ser Asn Gly Thr Ile His Ile Phe Arg Val Arg Ser 
            740                 745                 750         


Pro Asp Ser 
        755 


<210>  11
<211>  517
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Ala Gln Leu Leu Glu Glu Lys Leu Thr Cys Ala Ile Cys Leu 
1               5                   10                  15      


Gly Leu Tyr Gln Asp Pro Val Thr Leu Pro Cys Gly His Asn Phe Cys 
            20                  25                  30          


Gly Ala Cys Ile Arg Asp Trp Trp Asp Arg Cys Gly Lys Ala Cys Pro 
        35                  40                  45              


Glu Cys Arg Glu Pro Phe Pro Asp Gly Ala Glu Leu Arg Arg Asn Val 
    50                  55                  60                  


Ala Leu Ser Gly Val Leu Glu Val Val Arg Ala Gly Pro Ala Arg Asp 
65                  70                  75                  80  


Pro Gly Pro Asp Pro Gly Pro Gly Pro Asp Pro Ala Ala Arg Cys Pro 
                85                  90                  95      


Arg His Gly Arg Pro Leu Glu Leu Phe Cys Arg Thr Glu Gly Arg Cys 
            100                 105                 110         


Val Cys Ser Val Cys Thr Val Arg Glu Cys Arg Leu His Glu Arg Ala 
        115                 120                 125             


Leu Leu Asp Ala Glu Arg Leu Lys Arg Glu Ala Gln Leu Arg Ala Ser 
    130                 135                 140                 


Leu Glu Val Thr Gln Gln Gln Ala Thr Gln Ala Glu Gly Gln Leu Leu 
145                 150                 155                 160 


Glu Leu Arg Lys Gln Ser Ser Gln Ile Gln Asn Ser Ala Cys Ile Leu 
                165                 170                 175     


Ala Ser Trp Val Ser Gly Lys Phe Ser Ser Leu Leu Gln Ala Leu Glu 
            180                 185                 190         


Ile Gln His Thr Thr Ala Leu Arg Ser Ile Glu Val Ala Lys Thr Gln 
        195                 200                 205             


Ala Leu Ala Gln Ala Arg Asp Glu Glu Gln Arg Leu Arg Val His Leu 
    210                 215                 220                 


Glu Ala Val Ala Arg His Gly Cys Arg Ile Arg Glu Leu Leu Glu Gln 
225                 230                 235                 240 


Val Asp Glu Gln Thr Phe Leu Gln Glu Ser Gln Leu Leu Gln Pro Pro 
                245                 250                 255     


Gly Pro Leu Gly Pro Leu Thr Pro Leu Gln Trp Asp Glu Asp Gln Gln 
            260                 265                 270         


Leu Gly Asp Leu Lys Gln Leu Leu Ser Arg Leu Cys Gly Leu Leu Leu 
        275                 280                 285             


Glu Glu Gly Ser His Pro Gly Ala Pro Ala Lys Pro Val Asp Leu Ala 
    290                 295                 300                 


Pro Val Glu Ala Pro Gly Pro Leu Ala Pro Val Pro Ser Thr Val Cys 
305                 310                 315                 320 


Pro Leu Arg Arg Lys Leu Trp Gln Asn Tyr Arg Asn Leu Thr Phe Asp 
                325                 330                 335     


Pro Val Ser Ala Asn Arg His Phe Tyr Leu Ser Arg Gln Asp Gln Gln 
            340                 345                 350         


Val Lys His Cys Arg Gln Ser Arg Gly Pro Gly Gly Pro Gly Ser Phe 
        355                 360                 365             


Glu Leu Trp Gln Val Gln Cys Ala Gln Ser Phe Gln Ala Gly His His 
    370                 375                 380                 


Tyr Trp Glu Val Arg Ala Ser Asp His Ser Val Thr Leu Gly Val Ser 
385                 390                 395                 400 


Tyr Pro Gln Leu Pro Arg Cys Arg Leu Gly Pro His Thr Asp Asn Ile 
                405                 410                 415     


Gly Arg Gly Pro Cys Ser Trp Gly Leu Cys Val Gln Glu Asp Ser Leu 
            420                 425                 430         


Gln Ala Trp His Asn Gly Glu Ala Gln Arg Leu Pro Gly Val Ser Gly 
        435                 440                 445             


Arg Leu Leu Gly Met Asp Leu Asp Leu Ala Ser Gly Cys Leu Thr Phe 
    450                 455                 460                 


Tyr Ser Leu Glu Pro Gln Thr Gln Pro Leu Tyr Thr Phe His Ala Leu 
465                 470                 475                 480 


Phe Asn Gln Pro Leu Thr Pro Val Phe Trp Leu Leu Glu Gly Arg Thr 
                485                 490                 495     


Leu Thr Leu Cys His Gln Pro Gly Ala Val Phe Pro Leu Gly Pro Gln 
            500                 505                 510         


Glu Glu Val Leu Ser 
        515         


<210>  12
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
                165                 170                 175     


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
            180                 185                 190         


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
        195                 200                 205             


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
    210                 215                 220                 


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
225                 230                 235                 240 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 250 


<210>  13
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Met Leu Ser Leu Asn Asn Leu Gln Asn Ile Ile Tyr Asn Pro Val 
1               5                   10                  15      


Ile Pro Phe Val Gly Thr Ile Pro Asp Gln Leu Asp Pro Gly Thr Leu 
            20                  25                  30          


Ile Val Ile Arg Gly His Val Pro Ser Asp Ala Asp Arg Phe Gln Val 
        35                  40                  45              


Asp Leu Gln Asn Gly Ser Ser Met Lys Pro Arg Ala Asp Val Ala Phe 
    50                  55                  60                  


His Phe Asn Pro Arg Phe Lys Arg Ala Gly Cys Ile Val Cys Asn Thr 
65                  70                  75                  80  


Leu Ile Asn Glu Lys Trp Gly Arg Glu Glu Ile Thr Tyr Asp Thr Pro 
                85                  90                  95      


Phe Lys Arg Glu Lys Ser Phe Glu Ile Val Ile Met Val Leu Lys Asp 
            100                 105                 110         


Lys Phe Gln Val Ala Val Asn Gly Lys His Thr Leu Leu Tyr Gly His 
        115                 120                 125             


Arg Ile Gly Pro Glu Lys Ile Asp Thr Leu Gly Ile Tyr Gly Lys Val 
    130                 135                 140                 


Asn Ile His Ser Ile Gly Phe Ser Phe Ser Ser Asp Leu Gln Ser Thr 
145                 150                 155                 160 


Gln Ala Ser Ser Leu Glu Leu Thr Glu Ile Ser Arg Glu Asn Val Pro 
                165                 170                 175     


Lys Ser Gly Thr Pro Gln Leu Pro Ser Asn Arg Gly Gly Asp Ile Ser 
            180                 185                 190         


Lys Ile Ala Pro Arg Thr Val Tyr Thr Lys Ser Lys Asp Ser Thr Val 
        195                 200                 205             


Asn His Thr Leu Thr Cys Thr Lys Ile Pro Pro Met Asn Tyr Val Ser 
    210                 215                 220                 


Lys Arg Leu Pro Phe Ala Ala Arg Leu Asn Thr Pro Met Gly Pro Gly 
225                 230                 235                 240 


Arg Thr Val Val Val Lys Gly Glu Val Asn Ala Asn Ala Lys Ser Phe 
                245                 250                 255     


Asn Val Asp Leu Leu Ala Gly Lys Ser Lys Asp Ile Ala Leu His Leu 
            260                 265                 270         


Asn Pro Arg Leu Asn Ile Lys Ala Phe Val Arg Asn Ser Phe Leu Gln 
        275                 280                 285             


Glu Ser Trp Gly Glu Glu Glu Arg Asn Ile Thr Ser Phe Pro Phe Ser 
    290                 295                 300                 


Pro Gly Met Tyr Phe Glu Met Ile Ile Tyr Cys Asp Val Arg Glu Phe 
305                 310                 315                 320 


Lys Val Ala Val Asn Gly Val His Ser Leu Glu Tyr Lys His Arg Phe 
                325                 330                 335     


Lys Glu Leu Ser Ser Ile Asp Thr Leu Glu Ile Asn Gly Asp Ile His 
            340                 345                 350         


Leu Leu Glu Val Arg Ser Trp 
        355                 


<210>  14
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Phe Ser Gly Ser Gln Ala Pro Tyr Leu Ser Pro Ala Val Pro 
1               5                   10                  15      


Phe Ser Gly Thr Ile Gln Gly Gly Leu Gln Asp Gly Phe Gln Ile Thr 
            20                  25                  30          


Val Asn Gly Ala Val Leu Ser Ser Ser Gly Thr Arg Phe Ala Val Asp 
        35                  40                  45              


Phe Gln Thr Gly Phe Ser Gly Asn Asp Ile Ala Phe His Phe Asn Pro 
    50                  55                  60                  


Arg Phe Glu Asp Gly Gly Tyr Val Val Cys Asn Thr Arg Gln Lys Gly 
65                  70                  75                  80  


Arg Trp Gly Pro Glu Glu Arg Lys Met His Met Pro Phe Gln Lys Gly 
                85                  90                  95      


Met Pro Phe Asp Leu Cys Phe Leu Val Gln Ser Ser Asp Phe Lys Val 
            100                 105                 110         


Met Val Asn Gly Ser Leu Phe Val Gln Tyr Phe His Arg Val Pro Phe 
        115                 120                 125             


His Arg Val Asp Thr Ile Ser Val Asn Gly Ser Val Gln Leu Ser Tyr 
    130                 135                 140                 


Ile Ser Phe Gln Asn Pro Arg Thr Val Pro Val Gln Pro Ala Phe Ser 
145                 150                 155                 160 


Thr Val Pro Phe Ser Gln Pro Val Cys Phe Pro Pro Arg Pro Arg Gly 
                165                 170                 175     


Arg Arg Gln Lys Pro Pro Ser Val Arg Pro Ala Asn Pro Ala Pro Ile 
            180                 185                 190         


Thr Gln Thr Val Ile His Thr Val Gln Ser Ala Ser Gly Gln Met Phe 
        195                 200                 205             


Ser Thr Pro Ala Ile Pro Pro Met Met Tyr Pro His Pro Ala Tyr Pro 
    210                 215                 220                 


Met Pro Phe Ile Thr Thr Ile Pro Gly Gly Leu Tyr Pro Ser Lys Ser 
225                 230                 235                 240 


Ile Ile Leu Ser Gly Thr Val Leu Pro Ser Ala Gln Arg Phe His Ile 
                245                 250                 255     


Asn Leu Cys Ser Gly Ser His Ile Ala Phe His Met Asn Pro Arg Phe 
            260                 265                 270         


Asp Glu Asn Ala Val Val Arg Asn Thr Gln Ile Asn Asn Ser Trp Gly 
        275                 280                 285             


Ser Glu Glu Arg Ser Leu Pro Arg Lys Met Pro Phe Val Arg Gly Gln 
    290                 295                 300                 


Ser Phe Ser Val Trp Ile Leu Cys Glu Ala His Cys Leu Lys Val Ala 
305                 310                 315                 320 


Val Asp Gly Gln His Val Phe Glu Tyr Tyr His Arg Leu Arg Asn Leu 
                325                 330                 335     


Pro Thr Ile Asn Lys Leu Glu Val Gly Gly Asp Ile Gln Leu Thr His 
            340                 345                 350         


Val Gln Thr 
        355 


<210>  15
<211>  336
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Gln Pro Ser Gly Gly Arg Ala Pro Gly Thr Arg Ile Tyr Ser 
1               5                   10                  15      


Trp Ser Cys Pro Thr Val Met Ser Pro Gly Glu Lys Leu Asp Pro Ile 
            20                  25                  30          


Pro Asp Ser Phe Ile Leu Gln Pro Pro Val Phe His Pro Val Val Pro 
        35                  40                  45              


Tyr Val Thr Thr Ile Phe Gly Gly Leu His Ala Gly Lys Met Val Met 
    50                  55                  60                  


Leu Gln Gly Val Val Pro Leu Asp Ala His Arg Phe Gln Val Asp Phe 
65                  70                  75                  80  


Gln Cys Gly Cys Ser Leu Cys Pro Arg Pro Asp Ile Ala Phe His Phe 
                85                  90                  95      


Asn Pro Arg Phe His Thr Thr Lys Pro His Val Ile Cys Asn Thr Leu 
            100                 105                 110         


His Gly Gly Arg Trp Gln Arg Glu Ala Arg Trp Pro His Leu Ala Leu 
        115                 120                 125             


Arg Arg Gly Ser Ser Phe Leu Ile Leu Phe Leu Phe Gly Asn Glu Glu 
    130                 135                 140                 


Val Lys Val Ser Val Asn Gly Gln His Phe Leu His Phe Arg Tyr Arg 
145                 150                 155                 160 


Leu Pro Leu Ser His Val Asp Thr Leu Gly Ile Phe Gly Asp Ile Leu 
                165                 170                 175     


Val Glu Ala Val Gly Phe Leu Asn Ile Asn Pro Phe Val Glu Gly Ser 
            180                 185                 190         


Arg Glu Tyr Pro Ala Gly His Pro Phe Leu Leu Met Ser Pro Arg Leu 
        195                 200                 205             


Glu Val Pro Cys Ser His Ala Leu Pro Gln Gly Leu Ser Pro Gly Gln 
    210                 215                 220                 


Val Ile Ile Val Arg Gly Leu Val Leu Gln Glu Pro Lys His Phe Thr 
225                 230                 235                 240 


Val Ser Leu Arg Asp Gln Ala Ala His Ala Pro Val Thr Leu Arg Ala 
                245                 250                 255     


Ser Phe Ala Asp Arg Thr Leu Ala Trp Ile Ser Arg Trp Gly Gln Lys 
            260                 265                 270         


Lys Leu Ile Ser Ala Pro Phe Leu Phe Tyr Pro Gln Arg Phe Phe Glu 
        275                 280                 285             


Val Leu Leu Leu Phe Gln Glu Gly Gly Leu Lys Leu Ala Leu Asn Gly 
    290                 295                 300                 


Gln Gly Leu Gly Ala Thr Ser Met Asn Gln Gln Ala Leu Glu Gln Leu 
305                 310                 315                 320 


Arg Glu Leu Arg Ile Ser Gly Ser Val Gln Leu Tyr Cys Val His Ser 
                325                 330                 335     


<210>  16
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  16
gcaagauucu cgucuguuc                                                    19


<210>  17
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  17
ggaaugaaau ccggaagau                                                    19


<210>  18
<211>  19
<212>  RNA
<213>  Homo Sapiens

<400>  18
ggacaacugu uacuguucu                                                    19


<210>  19
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  19
gaacaccaag ucugugaaa                                                    19


<210>  20
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  20
gagaggagau ucaagaaau                                                    19


<210>  21
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  21
cagaagcacu cuaauaaga                                                    19


<210>  22
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  22
gggaacaaau ccauaagug                                                    19


<210>  23
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  23
gcuuugaguu ggacuauga                                                    19


<210>  24
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  24
gaccacaacu ggcgauacu                                                    19


<210>  25
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  25
gcagugaagu ccugucuaa                                                    19


<210>  26
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  26
ggaacaggac agcgacucu                                                    19


<210>  27
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  27
ccgcaucagg ugaacauca                                                    19


<210>  28
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  28
gaggaguacu gcaaguuua                                                    19


<210>  29
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  29
gcaaaggcau cgaccagaa                                                    19


<210>  30
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  30
gcaaaguuau cacggaauc                                                    19


<210>  31
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  31
aggauaaacu cucgggcau                                                    19


<210>  32
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  32
ggggaaagau gcagcugua                                                    19


<210>  33
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  33
gcaaagaguc ggccgacuu                                                    19


<210>  34
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  34
gcgcuggugc agaggauga                                                    19


<210>  35
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  35
ccgauggcuu cgacgaguu                                                    19


<210>  36
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  36
ggaaggauua ugugaguuu                                                    19


<210>  37
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  37
acuuggaaag gcugcgaaa                                                    19


<210>  38
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  38
aagcagaugu ggagcuacu                                                    19


<210>  39
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  39
ggacagccuc aguggauuc                                                    19


<210>  40
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pair (forward)

<400>  40
caccatggcc caactgagga ttaag                                             25


<210>  41
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pair (reverse)

<400>  41
tcagcgtctc ccaaagatat tagtgataga                                        30


<210>  42
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pair (forward)

<400>  42
caccatggca gacaattttt cgctccat                                          28


<210>  43
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer pair (reverse)

<400>  43
ttatatcatg gtatatgaag cact                                              24


<210>  44
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  44
tctcttgtct gacttgggct gcacagatcc tgggccaagg gacagaagaa agacagccta       60


<210>  45
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  45
ggagcagagc ctcccagatg gctgagttgg atctaatggc tccagggcca ctgcccaggg       60


<210>  46
<211>  13
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  n is a, c, g, or t

<400>  46
ggagcagagc nnn                                                          13


<210>  47
<211>  60
<212>  DNA
<213>  Homo sapiens

<400>  47
ccactgctca gcccccagcc cctctcagcc cagactctgg gtcacccagc ccagattctg       60


<210>  48
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  48

Leu Gln Ser His Leu Leu Thr Glu Pro Val Lys Asp His Asn Trp Arg 
1               5                   10                  15      


<210>  49
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  49

Leu Gln Ala Asn Gln Lys Ser Val Leu Val Ser Val Ser Glu Val Lys 
1               5                   10                  15      


