               SEQUENCE LISTING

<110>  MEDIZINISCHE UNIVERSITÄT WIEN

<120> Genotyping and treatment of cancer, in particular chronic lymphocytic leukemia

<130> R71281

<160> 88

<170> BiSSAP 1.3

<210> 1
<211> 15656
<212> DNA
<213> Homo sapiens

<220> 
<223> NOTCH2 exon 20 to last nucleotide upstream of START2

<400> 1
accctggtga atctctgcag tcggtctcca tgtaaaaaca aaggtacttg cgttcagaaa       60

aaagcagagt cccagtgcct atgtccatct ggatgggctg gtgcctattg tgacgtgccc      120

aatgtctctt gtgacatagc agcctccagg agaggtaagc tttgctccct tgggctcagg      180

tcattcactg cagtattgac tgtccagtgg catttagaga aggtatcatt tttttgtgga      240

ataagaggga agggcagata gtagtgggtg ggcagggctc tggggaaagg gctcaagaca      300

gaaggtgtaa gggtagagga ataggttcag agattcggag aagaatgtat ttgaaatgaa      360

actaaggtat attccacttt cagggtttat ttttaatatg catctggtac tgagggttgt      420

gaagaactgg ctaagaataa gattggatgt gtcagccagt ttagatttac ttgctcattg      480

gttgatttga accccatgtg tcacatgttc ttctatgaca tttctccctc actgggtttc      540

ccaggtgtgc ttgttgaaca cttgtgccag cactcaggtg tctgcatcaa tgctggcaac      600

acgcattact gtcagtgccc cctgggctat actgggagct actgtgagga gcaactcgat      660

gagtgtgcgt ccaacccctg ccagcacggg gcaacatgca gtgacttcat tggtggatac      720

agatgcgagg tgaggacact gagcaagcag aggtcatgga cctcccagga gattgtacaa      780

ctgtttgagc actgatatat tgaatttagc tgcttgtatc ttatattgat agtttataga      840

tttttaccaa tccccgtcat aatgtttacc actgtttctt tcagcctctc tgtgcaataa      900

gttaacaggt ccctagtatg atatttttat aggcgtctgg aaccatccca gctccttagg      960

cttgctttta ggattcagag ccaagagtca ctaccagagt gcattttaca ggcccaccca     1020

acatagcagt ccacacttcc ctgaatagca gctgagatag gaaaaactgc tttgtggagt     1080

gtccctttgg cccctgtcac ctttgtattt agtcattaat cagtcaacta gcaattttct     1140

ctcaaaaaaa aaaaatgttg ctcatcctgt tccccatagc atcatgctaa acgttacatg     1200

tatatatttg aggaagtatg tgtcttcaag gtacatgtca ctattttaat gtctgggctg     1260

ataatggtta gagcaagcaa gatattagca aaatgcctga gacattaatt tgataccaat     1320

tcaaaccatc aagcaacact gagaaaagct ttgcttctct attgttatat aaatgagcca     1380

acgatagctt ctgtattttg gcccctaggt tgtttatttc ttcacagcag gctggggctg     1440

ggtctcatta gctcaaaagc ctaccagtgc caaacccaaa ttttgacaca tctagttgtt     1500

ttaaacatag cccccaaata agcagatttt tagctattta gagcttgcct gctttgcata     1560

gcctgtaaaa ctgcagccaa aatctgctag ccatagtata agtaggacaa gatataccct     1620

ggggccatac agaccccagg ctgatgctgg cctttagagc tctctgaccc agagattcct     1680

gccactggct gttgagtgac atcacctaga ctccttctct gatccttctt tcccagagtt     1740

tacttgctgt cttcccctta ctcacctacc cctctggaag gtctcatgct atttgggact     1800

tctcccaggt gcaaacctgt caaagtgtcc aaataaagcc acctcacagc catatctttt     1860

ttcttggtca gccctgaaat ccttccaacc cctacagcca ccacagccag ccagccagcc     1920

ccacctccct ctacccctaa gcctatctca accagtttct cacacataga tccaatttcc     1980

taaacctgga gatcaataat tgcatgtctg tactaccatc cacatatgcc ttttgaccga     2040

gtcatagggt cctcatcaca tacggaggaa tgtgtatttt aaagatgagg aaacctgtac     2100

ccaggaggaa caaaaggttt gcacacaagt caaatctgaa acatccttca ttgtattcag     2160

tccttgcctt ccctttaaag tgcctttttc aactgaaaga ggagtaggta aatgccagta     2220

agctgcaggt tttctgtccc tgcatagaat gattagcaga gagtgtgatg gttccagaga     2280

aaacatacaa aagctaaatt aggaggtggg agacagtcac agaaatgttc cagatctcac     2340

tagctctcat ggtctgtttc cagtaatggt ccaatatttc ttgtcctttt tgtttcctca     2400

tggcagtgtg tcccaggcta tcagggtgtc aactgtgagt atgaagtgga tgagtgccag     2460

aatcagccct gccagaatgg aggcacctgt attgaccttg tgaaccattt caagtgctct     2520

tgcccaccag gcactcgggg tatgaaatca tccttatcca ttttccatcc agggcattgt     2580

cttaagttat aaatccattc ttagtgttca ggggatttta taaaattaaa gataggaaga     2640

ctagcttcat tccaagcatt tagttctaca tcctagtaat tcaagccatt ttattctccc     2700

atctcttgct agctctgatg ttgtggttta tgttgtcagt tttatctggt tgtttggcat     2760

cttgatattc catgaaacac agaatatgga agggatacaa cattagcata acattaaaaa     2820

attagcctgg tcagtaagat ttcttgttgc ttcacagaaa agcaactaat ggcctctaaa     2880

ataaacaatt tacatttacc tgcttttgta tttttttaat tagccaagtc ttacctctat     2940

aaggtggggg aatgaatgaa atgaaaatat ctgcctattt tcatagcttc aggggaggat     3000

actgatggtg taaggttcta ccttaggatg cagtaaggcc tgatgagaga tgcaaccctg     3060

gactgttgag tgatggggcc atcattcttc tgtgggcatt gccactgctt ttgaactgag     3120

tggtatggcc atcattctgc tgtggacatt gacactgctt ttgaaccatc ccttggaaag     3180

agctttgagt attgtttgtt agaagggatg tagttatgct ggggcctact ctgagaaggc     3240

tgtgaaaaaa atgtaaaagg ccatccacac tggtgagaaa ttcatccttg ttagtgtcaa     3300

agagaataga atgccagaga agtatttgta ttgccttaga gctttgtgtc agtaaagttt     3360

gataatttgc caccccaggt atcagagttt gactaaatta aaataggaga gtaccctagt     3420

agtaggctga ttattaagga atgaggttaa tgggaagaag aaaactaagg agaaacagtc     3480

tttaagtatt tgaagaattg tcctgtaaaa aggagaattg ttctttattc tagaaatcag     3540

tggttgagta gaaattaatt ccagttcatt gttagtttgt tcctttgaga aactgtactg     3600

gttaggacaa gctacgattc tggtgatagc tgttatcgta gttcatttat gttgctataa     3660

aagaatacct gagactaagt aatttatttt tcgaaagagg tatatttggc tcgcagttct     3720

ataggctgta caggaagcac ggtgccagca tctgcctctg gtgtgagcgt caggctgttt     3780

ccactcatgg tgaaaagtga agaagatcca gggacccaaa cacctcccat taggccccac     3840

ctccaacatt ggagatcaca ttttaacatg tggtttggtg cagtcaaact tcaagctata     3900

gcagctaatt aaacctcaaa tctcagagct taatataaca ctgattttgt cactcaaata     3960

aagtcgaata tgtgttgggc tacctttctc tgtgttttag atatgtggtt tgaaacacct     4020

ggcctccaag gcctccacag tacagggaag agggacagac ttgaagggtc atacagcagc     4080

ttccactagc tcagtctgga agcaacacat atcactatcc ctcgcagtat attgaccgga     4140

attattaaat ggtctctgtg acttcaaggg aggctgggaa atataggaga gtacatgagt     4200

attcatcaaa ctctaaaatc actactatac catgaacttt taattaataa gacatgtcca     4260

gtcctagaat ggatcatttc agaaggaaac aaaatttttg tctcttctaa ccatatggta     4320

aagatggctt agaatactag ttttgatatt atcattgaca gtctttttct ttcagcactt     4380

tgaatatatc atcccactgc tttctgatat ccatggtttt taatgagaaa tatgctgtta     4440

atcttattga ggttccctta tatgtgatac attgcttctt tcttgatgcc ttcaagattc     4500

tttatctttt gatagtttga ttatgatgta tgtaggtatg aatttctttg agtttatcct     4560

acttacagtt ccttggatta ttttactgtg tgtgcttgtt taggtatgtg gaacagtatt     4620

tttttatcct gacttaactt ctctggccat tggtaaacat tccaggaaac tctcaagtcc     4680

cataacccca ttgttagagt catcacaatg tgtgttttgg tcaccatatt tctaagcctt     4740

agatctttgc ctgcatgtcc caccagtttc ccaggtcaag ggctaaatgt aacagttctg     4800

cctcttccta ctactttgct tcaggctgag gttgagttct ctctcagttg atagatctgt     4860

ttatttctgg tggttccatt ctgatgggga aatatgcatt tatgctcatt ttactagcaa     4920

tccctaaata tcaaatattc tttgagacag ggagcatata ctagattttg tttgttttta     4980

cttttttgtt ttcaatttac tctatgtata aggtgatata tgcatatatg catatagacc     5040

aaaagtgtat tcacacatag aaaagtatac agtgaaaata cttctcattc ccatctctct     5100

tctggtgggc aaattttccc tctcctgcaa acatgtaatc gccacttttg gttgtttgtg     5160

tttctttcta gaatttttca aaaactgtat ccttcagaat ttctttatgt agagagaagc     5220

caaatgcaaa gatattttat ttcctttact ttttactctg aagatagaat attagacaca     5280

ttttttgcac ttgatttttt tttacttaat tggagatatt ttcatatcaa aatatagaac     5340

ttcctctctc tctctctgag atagatagat agatagatag atagatagat agatagatag     5400

atatttgttt gtttgtttgt tttgagatgg agttttgctc ttgttgccca ggctggagtg     5460

caatggtatg atctcagctc accgcaacct ccgcctcctg ggttcgagtg attttcctgc     5520

ctcagcgccc tgagtagctg ggattacagg catgtgccac catgcctggc tgattttgta     5580

tttttaatag agacagggtt tctccatgtt ggtcaggctg gtcttgaact cctggcctca     5640

agcaatccac ccgcctcagc ctcccaaagt gctgggatga caggcgtgag ccaccacacc     5700

cagcctgaac ttcctcaata ttttttatag ctacagaatt cccttttaca ggcataccat     5760

attttaacca gtgccatcat gatagatatt tcagttatct tgcaggcata taagtatatt     5820

ggtgaaataa attttcagaa atagaatcgc tggattggat aatatgtgca tttatcattt     5880

taatcagtga ttgcagtata tcagcatatt ggctttttct taaggtggag aatatatttt     5940

catttaagaa tcattttctt ttgatttttt ttgcagtttc tttgtttata tatatatata     6000

tgtatatata catatatata tatatacaca catatatctt ttttcccaca ttaagttgtt     6060

gatgtaatgt tttgtggaaa ttggctatga tataaaaaaa caaatatatt cccagtattt     6120

ttttatcttt tttctttata gtgattttta gtgcacactt ttacttttta atcaagttga     6180

atttatcact tttaaaatgg cttctggatt ttgagttgta gttagcaaca tcatatacac     6240

ttgaagatcg taaagaaatt ctcccatatt ttcttcaagt acttttgcca tatgactact     6300

catttgttaa tacacaattt attgaatatt ttgtttttta tatatataat gatttgagat     6360

ggcacctttg ccagattcta aattcccatg tgtatttttg gtgttcttct ggattttctt     6420

tattttctgt gttattctat taattcacca ataacgttct atttcaatta ttaaggatct     6480

tcttcttcat agttttcctg gttatttttt ttcacataat tttataatca gcttgtctgt     6540

taataaattc ctgttgataa tttttagtgg ggtctcatta aatttatgaa ttatagtata     6600

gagaaaactg ataactttat gatgaggagt cttgctaacc aaatcctggt atgtctttcc     6660

atttattcaa gtctcttttg tgtctgttag gacagtatta aagttgtctt catttaggtg     6720

taacacattt cttgtgaaga ttgttcctag gtattttatc tttggtaatt tggtaattgc     6780

ttttgaaaat tgggccttac tttacattta aaaaaaaaaa tcttgctttt gttagtgtat     6840

gctacaatgc aagtggcagg aatacataca gaactgtttt cttttgtacc tttttttttt     6900

ttttttttaa gacagagtct tgctctgttg cccaggctgg agtgcagtag cgcaatctcg     6960

gcttactgca agctccacct cccaggttca tgccattctc ctgcctcagc ctcccgagta     7020

gctgggacta caagcgcccg ccaccatgcc tggctaattt tttttttgta ttttttagtg     7080

gagacggggt ttcaccatgt tagccaggat ggtctcgatc tcctgacctc gtgatccacc     7140

tgccttggcc tcccagagtg ctgggattac aggcttgagc cactgcaccc agcctgtacc     7200

ttttttttta attatgatta ttattatttt ttgagacaga gtcttgctct gttgcccagg     7260

ctggagtgca gtggcataac ctcggctcac tgcaagcttc atctcccggt ttcaagtgat     7320

tctcctgcct cagcctccca agtagctgag attacagaca tgtaccacca cacgcagcta     7380

atttttgtat atttagtaga gatggggttt cactgtgttg ggcagattgg tcttgaactc     7440

ctgacctcaa gtgatccgcc tgccttagcc tcccaaagtg ctgggattac aggtgtgagc     7500

cactgtgccc agcctctttt gtgccttttt gaattaatca tagaataatt tctagaatag     7560

tcattgattt cttttgtttc tttgtaagac actatatgca gatattcata ctagatggct     7620

catttacatc tatagtacaa taaattagtc ctgttttaaa tggaataact tttgaactct     7680

cagcaggaaa tttatcctct atttttgtta aataaaaagc attggtgcac ttatacacta     7740

ttacagaaaa aagccagtga ttataaaact taaaaatgta tttcattcaa aattcagttc     7800

cagttgttac caatattttt acataaccta tgtatagtca tgggtcactt aacagtgggg     7860

atatgttctg agaaatatgc ccttaggcaa tttcattgtt gtacaatcat catggagtgt     7920

aattacacaa acagagagag tatggcttac tacacaccta ggctccaaac ctgcaccttg     7980

ttttactgaa ctgaatattg taggcaatta taacacaatg gtaagtattt atgtgtctga     8040

acatatttaa gaagaggtac agtagaagat ttaaaaggta cagtaaaaat acaatataaa     8100

agataaaaaa tagtacacct gtatagggca tttactatga aaggagcttg caagactgga     8160

acttgctggg tgagtcagtg aatggtaagt gaatgtgaag gcctaggaca ttactgtaca     8220

ctactgcaga ctttgtaaat actgtacacc taagctacac tgaatttatt taaaaagtaa     8280

ttgtgctatg acattacaag gctatgatgt tactaggcaa caggaatttg tcagcttcag     8340

cttcattatg ggaccactgt cgtatgtgct gcctgcattg actaaaatgt cattatgcgg     8400

ttgcataact gtatttattg ttatgttctt ttttggactg tttttatatt ttggattata     8460

ctttggaaaa attactgagc ctctcttgag ctccagtttc cttctctttg agatgggaca     8520

aataatagga cctacaccat agggtgctac ttcactggat tgtgtgggag agtacatgcg     8580

gagccctagt atgttctttc ctttacttgt acaactcacc aggatgacag ctgtcatgaa     8640

taaagagtgt gctttgccct gcccaactac aaggtcccac taccagttga ggagtatact     8700

ctgattcatt gtgaaaatgc caacaagggt ggttatccct tgctggaaag caggttaaaa     8760

ggattttcat aattctgtac ctcttctctt tcctccaggc ctactctgtg aagagaacat     8820

tgatgactgt gcccggggtc cccattgcct taatggtggt cagtgcatgg ataggattgg     8880

aggctacagt tgtcgctgct tgcctggctt tgctggggag cgttgtgagg gagacatcaa     8940

cgagtgcctc tccaacccct gcagctctga gggcagcctg gactgtatac agctcaccaa     9000

tgactacctg tgtgtttgcc gtagtgcctt tactggtgag aagctctcta gcctcctggc     9060

cactctgcct tggaggatgg ttttagtgaa caaattgggc cctgtgagtt gtcccagacc     9120

caagtgaagc ttttcttata taagaaaaac aacagcagct taatttttta aagccagttt     9180

tttcttagtc tgtactttat ggatgttatg atcagtgtct acctttaatt tttcctaaga     9240

gattcttttg ttgtgcattg attatatcat gctatggcag gaatattttt tacaatgtat     9300

attgaaagta gttgaacaaa ataacatttt ttaatagtgg caaaatatcc aaaacctaaa     9360

atttactatc tgaatcattt taaagtgtac agtgtacagt tcagtggcat tgtttagtac     9420

attgacattg ttgttctact atcaccccca ttcattcaca gaactctttt catctgaaca     9480

aaataacatt ttgttttaag gaaccttacg tctaactccg gtttcttcac cctgcctcct     9540

ttgacatgtg atggcttgaa ttactgggta gttcctgcca ccatgatctt tccaccccta     9600

ggactcagag aagcttagga ccctgcttag atacttaaag ggggcaggtc caaattcaag     9660

tgtgtttaac caaagatcag ttgatgtggg tatgaaatga aaagttgcag tggtcacaag     9720

taatgccttg cccagtaaag gcttggccat gttcctactc tgttcccaag cttctttctt     9780

tcatcacagg gcctgaagat gaccaagctc tgcctcagaa taggggtctt atcacaagaa     9840

cttactagtt acttctggag agggcagcat ggtgactttt gggaactaaa atagttgttt     9900

gtatccagat gtggcaggat actcagattt gaaatttatc atgcatttcc tggggtctgt     9960

agttgtattt cttatatgga gggtgtgatc agattcctta ggagtcagaa aataggcttt    10020

aatagtctgt ttacaaacaa ttcatcaagc tgaactctgc tacatcctga gcccatctcc    10080

agccatcttt ccttccaact ttaaagatat gctaccttac aatcttggaa ttttgtaaag    10140

aatgggaggg attctgcaat atggaagctc cctggataca ctaacatcaa aaaagaaata    10200

gtccattgtg aacataatag ctattgaggc aatgtggaac agaataagta tgaataatct    10260

gtctacagcc tcgtattggc caaactgcac tttgaaagcc aaagcatcaa aactggctcc    10320

tgtttctttc attgcccctg aggctttttt ctctggaaac acaagcattt gcaaagtaag    10380

ggggaagcag gagaaggaag gaatggagac cactttgaag tagtatccca cagccaggaa    10440

gtagtgtttg tgcattttcc acatttgtga atgaaaaaaa aaaaatccct tgaatacatt    10500

gagcacagtt attgtgggat gctgttgcag agataaacag caagggactg gtggtccacc    10560

aagctgtgtc catgtggtgg ctgctcttgg ttagcggctg ctgctgtgat ttgaagagac    10620

aaacatttat acctcttgct gcttgatctc gttggccaaa aacattacta tttttatttc    10680

atttttaaag ctacctcttc tttcccaagt gaccaccggc caaatggggc ctatctcctg    10740

ctgttggcca ggagtcccag ctgtgccctg cgtctcctct gtggttccag ttgcctcgtt    10800

ctttatcttg gagcagtggc ccccaggggc cttccgtttt agaactattc ctagaggaaa    10860

ctaactctag gaaaattaag ctgtgtttta aggaatacga gttaggttac agaaaggcca    10920

aaaagtgatt gaaatgaggt atcacagatg aaaattctct ataccgcaaa tcaccattta    10980

aatgtattgg cctggtgtag cctctcctat gaagtagata acattaacaa aatgcagtga    11040

atagtttttc aactgttttt ttgcaactta tgaaagctaa aatgacttca aaaagctgaa    11100

gtgtgatttc tctttttttg atgggattta agtcactttt ctcacccacc ctgttgtgtg    11160

agttggtact tactgtgtag gcaagacaga gtaagggact ggcctgagct ggtgacaggc    11220

caatcatgtt gagatgcagt gagtgttttc tttctatgct cagattacca caggcctaga    11280

actgaactct ctcacacttg cttcacctat ggctagttcc catcccagca aagtttgttg    11340

agtaacttgc agtgactact tctgcctttt aaaacctttt ttatttttta ttttctgagg    11400

ccggcactgt gaaaccttcg tcgatgtgtg tccccagatg ccctgcctga atggagggac    11460

ttgtgctgtg gccagtaaca tgcctgatgg tttcatttgc cgttgtcccc cggtaagtgc    11520

cctgttgctc atctaagaag gggcattgtc tcttccatac aatctgtgaa cagaactgag    11580

attaaacctg gttttaccaa tcttcgaaat gggaagattt ctcaatttta gctctttcag    11640

aggaaagtgc ttgggttttt ccatttaaag ctgtttacaa gtgacaaaac aaaacaaaaa    11700

caaataaaag ctgtttagac actcccagaa acagtgagct tcccaatcca tgactgtcag    11760

tcttaagaaa aactaaggga aaaccacaaa aagtggtgga gtgccccctt gaaaataggg    11820

ctgatgtgtg gggcttcttg gccccaggct ggagggtaat ctcactgccc agattgggcc    11880

agagttggtg gaaatgctgc tcttacattc tttagcagga accatttgga agcaagttgt    11940

ctcttaaagt agagggaagc tcaattttag ctatttgcta tacccattct tttatcactg    12000

ccagaggttg aaaccttccc aaaacaagag atccctatgc ctcgggagat accaaaagga    12060

aacctgtcta gtaaccttgg cttgggctga acgggaagta cagaagggag tgagatgtgg    12120

aggttttcta gaaacctcaa acttccaata tgactgtttt cctaccaatg ccatttttat    12180

ttcctcactg atttccacag ggattttccg gggcaaggtg ccagagcagc tgtggacaag    12240

tgaaatgtag gaagggggag cagtgtgtgc acaccgcctc tggaccccgc tgcttctgcc    12300

ccagtccccg ggactgcgag tcaggctgtg ccagtagccc ctgccagcac gggggcagct    12360

gccaccctca gcgccagcct ccttattact cctgccagtg tgccccacca ttctcgggta    12420

gccgctgtga actctacacg gcacccccca gcacccctcc tgccacctgt ctgagccagt    12480

attgtgccga caaagctcgg gatggcgtct gtgatgaggc ctgcaacagc catgcctgcc    12540

agtgggatgg gggtgactgt tctctcacca tggagaaccc ctgggccaac tgctcctccc    12600

cacttccctg ctgggattat atcaacaacc agtgtgatga gctgtgcaac acggtcgagt    12660

gcctgtttga caactttgaa tgccagggga acagcaagac atgcaagtaa gggcttcacg    12720

ttttccagaa ctgaagggga ctgtcactaa cacacttcag tttctcgttc ttgctcctaa    12780

ccactccagt gcttcagcct aagctgcctc tgcttttcag atggtgccag ccttgtccca    12840

tcgcacactg ccctgtgctc tcccttgctg acaatgggcc aggaatgctc attgcataat    12900

gaccctctct ctctgcctat ctttgccttc tcacctgctg ccttcgtgac ctcctggggg    12960

atataacttt tggaagtggt gtttcccact tcaagcagcc tctcacataa cctgcctgca    13020

ggatggatgg aaaggtctgt atctctctct tcaccccatt cctttcccta agactgtttt    13080

tccccatcta gatttatcag gaagcatgaa ttagattaag tctgtgaacc ctcccggtct    13140

taattgtata ggatgctcta tggtttactt aggaactttc ctattaacta gccattccat    13200

ataatttaat cccaattaat tctcagcaac tcacgaggca taggtattac taacattctt    13260

tcataggtga gagaacttag gcccaagggt taaagaactt gccaaagcaa gttgtttctt    13320

tgactcctaa tcttctgatt gagctagcat gaaaagttgt accaaatagt ataaatatca    13380

aggggtaggg gatgaggaga ggagagtata gatggaatag tttgtacatc atttaggttt    13440

gggggttcta attccttttc caaatattga aagagcctgt acaagtaata tctggtgtgc    13500

tataaggaca tacccatctg cctttacctt ctgtagttgg gattcactct tgaaagggaa    13560

agaaatgggt catgttaata ttgttctctg tatggcaact ctcaatggtt cagggccttg    13620

tatcaagttt ctagaggcat ctttcacttc ctaaagcccg ttgttacctt actgggggca    13680

atggatttct ctaaagtaga ggaagcatga accaggttga cttttgtttc agatatgcag    13740

ctttgtttga aaacctgact taacaggctt gtaaactgcc tgggagcccc taagctcctg    13800

cagcatagtg agtacaatgt tcttcattta ggaagtactc aacaaggatg agtggcatag    13860

gcatcaggga taggagatgc aaagaaggtt ttgtggggca tttgggtcct gggtgtgggc    13920

cacagaaaat gggtaggaaa atccacagta gttccaaatg aaaaagcaaa tagagctcca    13980

gtctaatctg agctcttttg cctgttctct gcttcccctt acctaggtat gacaaatact    14040

gtgcagacca cttcaaagac aaccactgtg accaggggtg caacagtgag gagtgtggtt    14100

gggatgggct ggactgtgct gctgaccaac ctgagaacct ggcagaaggt accctggtta    14160

ttgtggtatt gatgccacct gaacaactgc tccaggatgc tcgcagcttc ttgcgggcac    14220

tgggtaccct gctccacacc aacctgcgca ttaagcggga ctcccagggg gaactcatgg    14280

tgtaccccta ttatggtgag aagtcagctg ctatgaagaa acagaggatg acacgcagat    14340

cccttcctgg tgaacaagaa caggaggtgg ctgggtaggt gtttggtttc tgaacttcaa    14400

ggctaatttt atgaagccta gcactttgac atatagcaca agtcataact caacctatag    14460

aaatgcaaag atcagaaaaa tagaatggcc caccacttaa gataaacccg ttaccccagt    14520

acttacgttt aaatgtaaag atatgccttc gtcttggctg aaaagtgggc aggggtacac    14580

aggaggcaga atgtctggaa ggcctcctca gatgccagaa tccataacct tttgccagag    14640

ttgcctcaaa tccctttatt agtgacattc ctttttacat taatcattgc cttattgtta    14700

aggcccttct ttagaatata tgtctctttg acacaggtaa tgatcttcag ttgctctgtc    14760

attcacacct cactctttgt tggtatattg tcaaactttc aaccctccag ctagctgaga    14820

taccaatgca gagacaaagg aaaataagga ctaaaaacac acagggatgt atgtttagag    14880

tagcaccaag taccactgag taggtatgaa agagtggaag aagaccactg aaaccttcgg    14940

gaggaaagca cagcttctca ctttgtcatg cattgcctca gccagaaggc tttggtcagc    15000

cagactaagg aaggtgggac atcctctatg tgggaattag tgtttaagat ctcaagggac    15060

agtattctaa ttcctgagat atgtcttaag gcagcatccc agaggtgggg acctgatgct    15120

gaaggggagg aagggaggct cctgtcaccc tttatgacat gttctgcctg acctgcactc    15180

ttctgtttta cccccatctc tcctcctccg cttctccctt ggcatcccac agctctaaag    15240

tctttctgga aattgacaac cgccagtgtg ttcaagactc agaccactgc ttcaagaaca    15300

cggatgcagc agcagctctc ctggcctctc acgccataca ggggaccctg tcataccctc    15360

ttgtgtctgt cgtcagtgag tggcactggt gtaaagggga aaggtggcgg gggaagagtg    15420

tcaattgggg gaacaatttt cattatgtag ccctctattt tttcaggact gttgaggtca    15480

aagttgccct ctaaatgaat ctaatgctga cattgagagg ttaatgtttt attcagcact    15540

ttccctgtct ctgtggactt tcaggtgaat ccctgactcc agaacgcact cagctcctct    15600

atctccttgc tgttgctgtt gtcatcattc tgtttattat tctgctgggg gtaatc        15656


<210> 2
<211> 15502
<212> DNA
<213> Homo sapiens

<220> 
<223> NOTCH2 starting downstream of exon 20 and ending upstream of
      START2

<400> 2
gtaagctttg ctcccttggg ctcaggtcat tcactgcagt attgactgtc cagtggcatt       60

tagagaaggt atcatttttt tgtggaataa gagggaaggg cagatagtag tgggtgggca      120

gggctctggg gaaagggctc aagacagaag gtgtaagggt agaggaatag gttcagagat      180

tcggagaaga atgtatttga aatgaaacta aggtatattc cactttcagg gtttattttt      240

aatatgcatc tggtactgag ggttgtgaag aactggctaa gaataagatt ggatgtgtca      300

gccagtttag atttacttgc tcattggttg atttgaaccc catgtgtcac atgttcttct      360

atgacatttc tccctcactg ggtttcccag gtgtgcttgt tgaacacttg tgccagcact      420

caggtgtctg catcaatgct ggcaacacgc attactgtca gtgccccctg ggctatactg      480

ggagctactg tgaggagcaa ctcgatgagt gtgcgtccaa cccctgccag cacggggcaa      540

catgcagtga cttcattggt ggatacagat gcgaggtgag gacactgagc aagcagaggt      600

catggacctc ccaggagatt gtacaactgt ttgagcactg atatattgaa tttagctgct      660

tgtatcttat attgatagtt tatagatttt taccaatccc cgtcataatg tttaccactg      720

tttctttcag cctctctgtg caataagtta acaggtccct agtatgatat ttttataggc      780

gtctggaacc atcccagctc cttaggcttg cttttaggat tcagagccaa gagtcactac      840

cagagtgcat tttacaggcc cacccaacat agcagtccac acttccctga atagcagctg      900

agataggaaa aactgctttg tggagtgtcc ctttggcccc tgtcaccttt gtatttagtc      960

attaatcagt caactagcaa ttttctctca aaaaaaaaaa atgttgctca tcctgttccc     1020

catagcatca tgctaaacgt tacatgtata tatttgagga agtatgtgtc ttcaaggtac     1080

atgtcactat tttaatgtct gggctgataa tggttagagc aagcaagata ttagcaaaat     1140

gcctgagaca ttaatttgat accaattcaa accatcaagc aacactgaga aaagctttgc     1200

ttctctattg ttatataaat gagccaacga tagcttctgt attttggccc ctaggttgtt     1260

tatttcttca cagcaggctg gggctgggtc tcattagctc aaaagcctac cagtgccaaa     1320

cccaaatttt gacacatcta gttgttttaa acatagcccc caaataagca gatttttagc     1380

tatttagagc ttgcctgctt tgcatagcct gtaaaactgc agccaaaatc tgctagccat     1440

agtataagta ggacaagata taccctgggg ccatacagac cccaggctga tgctggcctt     1500

tagagctctc tgacccagag attcctgcca ctggctgttg agtgacatca cctagactcc     1560

ttctctgatc cttctttccc agagtttact tgctgtcttc cccttactca cctacccctc     1620

tggaaggtct catgctattt gggacttctc ccaggtgcaa acctgtcaaa gtgtccaaat     1680

aaagccacct cacagccata tcttttttct tggtcagccc tgaaatcctt ccaaccccta     1740

cagccaccac agccagccag ccagccccac ctccctctac ccctaagcct atctcaacca     1800

gtttctcaca catagatcca atttcctaaa cctggagatc aataattgca tgtctgtact     1860

accatccaca tatgcctttt gaccgagtca tagggtcctc atcacatacg gaggaatgtg     1920

tattttaaag atgaggaaac ctgtacccag gaggaacaaa aggtttgcac acaagtcaaa     1980

tctgaaacat ccttcattgt attcagtcct tgccttccct ttaaagtgcc tttttcaact     2040

gaaagaggag taggtaaatg ccagtaagct gcaggttttc tgtccctgca tagaatgatt     2100

agcagagagt gtgatggttc cagagaaaac atacaaaagc taaattagga ggtgggagac     2160

agtcacagaa atgttccaga tctcactagc tctcatggtc tgtttccagt aatggtccaa     2220

tatttcttgt cctttttgtt tcctcatggc agtgtgtccc aggctatcag ggtgtcaact     2280

gtgagtatga agtggatgag tgccagaatc agccctgcca gaatggaggc acctgtattg     2340

accttgtgaa ccatttcaag tgctcttgcc caccaggcac tcggggtatg aaatcatcct     2400

tatccatttt ccatccaggg cattgtctta agttataaat ccattcttag tgttcagggg     2460

attttataaa attaaagata ggaagactag cttcattcca agcatttagt tctacatcct     2520

agtaattcaa gccattttat tctcccatct cttgctagct ctgatgttgt ggtttatgtt     2580

gtcagtttta tctggttgtt tggcatcttg atattccatg aaacacagaa tatggaaggg     2640

atacaacatt agcataacat taaaaaatta gcctggtcag taagatttct tgttgcttca     2700

cagaaaagca actaatggcc tctaaaataa acaatttaca tttacctgct tttgtatttt     2760

tttaattagc caagtcttac ctctataagg tgggggaatg aatgaaatga aaatatctgc     2820

ctattttcat agcttcaggg gaggatactg atggtgtaag gttctacctt aggatgcagt     2880

aaggcctgat gagagatgca accctggact gttgagtgat ggggccatca ttcttctgtg     2940

ggcattgcca ctgcttttga actgagtggt atggccatca ttctgctgtg gacattgaca     3000

ctgcttttga accatccctt ggaaagagct ttgagtattg tttgttagaa gggatgtagt     3060

tatgctgggg cctactctga gaaggctgtg aaaaaaatgt aaaaggccat ccacactggt     3120

gagaaattca tccttgttag tgtcaaagag aatagaatgc cagagaagta tttgtattgc     3180

cttagagctt tgtgtcagta aagtttgata atttgccacc ccaggtatca gagtttgact     3240

aaattaaaat aggagagtac cctagtagta ggctgattat taaggaatga ggttaatggg     3300

aagaagaaaa ctaaggagaa acagtcttta agtatttgaa gaattgtcct gtaaaaagga     3360

gaattgttct ttattctaga aatcagtggt tgagtagaaa ttaattccag ttcattgtta     3420

gtttgttcct ttgagaaact gtactggtta ggacaagcta cgattctggt gatagctgtt     3480

atcgtagttc atttatgttg ctataaaaga atacctgaga ctaagtaatt tatttttcga     3540

aagaggtata tttggctcgc agttctatag gctgtacagg aagcacggtg ccagcatctg     3600

cctctggtgt gagcgtcagg ctgtttccac tcatggtgaa aagtgaagaa gatccaggga     3660

cccaaacacc tcccattagg ccccacctcc aacattggag atcacatttt aacatgtggt     3720

ttggtgcagt caaacttcaa gctatagcag ctaattaaac ctcaaatctc agagcttaat     3780

ataacactga ttttgtcact caaataaagt cgaatatgtg ttgggctacc tttctctgtg     3840

ttttagatat gtggtttgaa acacctggcc tccaaggcct ccacagtaca gggaagaggg     3900

acagacttga agggtcatac agcagcttcc actagctcag tctggaagca acacatatca     3960

ctatccctcg cagtatattg accggaatta ttaaatggtc tctgtgactt caagggaggc     4020

tgggaaatat aggagagtac atgagtattc atcaaactct aaaatcacta ctataccatg     4080

aacttttaat taataagaca tgtccagtcc tagaatggat catttcagaa ggaaacaaaa     4140

tttttgtctc ttctaaccat atggtaaaga tggcttagaa tactagtttt gatattatca     4200

ttgacagtct ttttctttca gcactttgaa tatatcatcc cactgctttc tgatatccat     4260

ggtttttaat gagaaatatg ctgttaatct tattgaggtt cccttatatg tgatacattg     4320

cttctttctt gatgccttca agattcttta tcttttgata gtttgattat gatgtatgta     4380

ggtatgaatt tctttgagtt tatcctactt acagttcctt ggattatttt actgtgtgtg     4440

cttgtttagg tatgtggaac agtatttttt tatcctgact taacttctct ggccattggt     4500

aaacattcca ggaaactctc aagtcccata accccattgt tagagtcatc acaatgtgtg     4560

ttttggtcac catatttcta agccttagat ctttgcctgc atgtcccacc agtttcccag     4620

gtcaagggct aaatgtaaca gttctgcctc ttcctactac tttgcttcag gctgaggttg     4680

agttctctct cagttgatag atctgtttat ttctggtggt tccattctga tggggaaata     4740

tgcatttatg ctcattttac tagcaatccc taaatatcaa atattctttg agacagggag     4800

catatactag attttgtttg tttttacttt tttgttttca atttactcta tgtataaggt     4860

gatatatgca tatatgcata tagaccaaaa gtgtattcac acatagaaaa gtatacagtg     4920

aaaatacttc tcattcccat ctctcttctg gtgggcaaat tttccctctc ctgcaaacat     4980

gtaatcgcca cttttggttg tttgtgtttc tttctagaat ttttcaaaaa ctgtatcctt     5040

cagaatttct ttatgtagag agaagccaaa tgcaaagata ttttatttcc tttacttttt     5100

actctgaaga tagaatatta gacacatttt ttgcacttga ttttttttta cttaattgga     5160

gatattttca tatcaaaata tagaacttcc tctctctctc tctgagatag atagatagat     5220

agatagatag atagatagat agatagatat ttgtttgttt gtttgttttg agatggagtt     5280

ttgctcttgt tgcccaggct ggagtgcaat ggtatgatct cagctcaccg caacctccgc     5340

ctcctgggtt cgagtgattt tcctgcctca gcgccctgag tagctgggat tacaggcatg     5400

tgccaccatg cctggctgat tttgtatttt taatagagac agggtttctc catgttggtc     5460

aggctggtct tgaactcctg gcctcaagca atccacccgc ctcagcctcc caaagtgctg     5520

ggatgacagg cgtgagccac cacacccagc ctgaacttcc tcaatatttt ttatagctac     5580

agaattccct tttacaggca taccatattt taaccagtgc catcatgata gatatttcag     5640

ttatcttgca ggcatataag tatattggtg aaataaattt tcagaaatag aatcgctgga     5700

ttggataata tgtgcattta tcattttaat cagtgattgc agtatatcag catattggct     5760

ttttcttaag gtggagaata tattttcatt taagaatcat tttcttttga ttttttttgc     5820

agtttctttg tttatatata tatatatgta tatatacata tatatatata tacacacata     5880

tatctttttt cccacattaa gttgttgatg taatgttttg tggaaattgg ctatgatata     5940

aaaaaacaaa tatattccca gtattttttt atcttttttc tttatagtga tttttagtgc     6000

acacttttac tttttaatca agttgaattt atcactttta aaatggcttc tggattttga     6060

gttgtagtta gcaacatcat atacacttga agatcgtaaa gaaattctcc catattttct     6120

tcaagtactt ttgccatatg actactcatt tgttaataca caatttattg aatattttgt     6180

tttttatata tataatgatt tgagatggca cctttgccag attctaaatt cccatgtgta     6240

tttttggtgt tcttctggat tttctttatt ttctgtgtta ttctattaat tcaccaataa     6300

cgttctattt caattattaa ggatcttctt cttcatagtt ttcctggtta ttttttttca     6360

cataatttta taatcagctt gtctgttaat aaattcctgt tgataatttt tagtggggtc     6420

tcattaaatt tatgaattat agtatagaga aaactgataa ctttatgatg aggagtcttg     6480

ctaaccaaat cctggtatgt ctttccattt attcaagtct cttttgtgtc tgttaggaca     6540

gtattaaagt tgtcttcatt taggtgtaac acatttcttg tgaagattgt tcctaggtat     6600

tttatctttg gtaatttggt aattgctttt gaaaattggg ccttacttta catttaaaaa     6660

aaaaaatctt gcttttgtta gtgtatgcta caatgcaagt ggcaggaata catacagaac     6720

tgttttcttt tgtacctttt tttttttttt ttttaagaca gagtcttgct ctgttgccca     6780

ggctggagtg cagtagcgca atctcggctt actgcaagct ccacctccca ggttcatgcc     6840

attctcctgc ctcagcctcc cgagtagctg ggactacaag cgcccgccac catgcctggc     6900

taattttttt tttgtatttt ttagtggaga cggggtttca ccatgttagc caggatggtc     6960

tcgatctcct gacctcgtga tccacctgcc ttggcctccc agagtgctgg gattacaggc     7020

ttgagccact gcacccagcc tgtacctttt tttttaatta tgattattat tattttttga     7080

gacagagtct tgctctgttg cccaggctgg agtgcagtgg cataacctcg gctcactgca     7140

agcttcatct cccggtttca agtgattctc ctgcctcagc ctcccaagta gctgagatta     7200

cagacatgta ccaccacacg cagctaattt ttgtatattt agtagagatg gggtttcact     7260

gtgttgggca gattggtctt gaactcctga cctcaagtga tccgcctgcc ttagcctccc     7320

aaagtgctgg gattacaggt gtgagccact gtgcccagcc tcttttgtgc ctttttgaat     7380

taatcataga ataatttcta gaatagtcat tgatttcttt tgtttctttg taagacacta     7440

tatgcagata ttcatactag atggctcatt tacatctata gtacaataaa ttagtcctgt     7500

tttaaatgga ataacttttg aactctcagc aggaaattta tcctctattt ttgttaaata     7560

aaaagcattg gtgcacttat acactattac agaaaaaagc cagtgattat aaaacttaaa     7620

aatgtatttc attcaaaatt cagttccagt tgttaccaat atttttacat aacctatgta     7680

tagtcatggg tcacttaaca gtggggatat gttctgagaa atatgccctt aggcaatttc     7740

attgttgtac aatcatcatg gagtgtaatt acacaaacag agagagtatg gcttactaca     7800

cacctaggct ccaaacctgc accttgtttt actgaactga atattgtagg caattataac     7860

acaatggtaa gtatttatgt gtctgaacat atttaagaag aggtacagta gaagatttaa     7920

aaggtacagt aaaaatacaa tataaaagat aaaaaatagt acacctgtat agggcattta     7980

ctatgaaagg agcttgcaag actggaactt gctgggtgag tcagtgaatg gtaagtgaat     8040

gtgaaggcct aggacattac tgtacactac tgcagacttt gtaaatactg tacacctaag     8100

ctacactgaa tttatttaaa aagtaattgt gctatgacat tacaaggcta tgatgttact     8160

aggcaacagg aatttgtcag cttcagcttc attatgggac cactgtcgta tgtgctgcct     8220

gcattgacta aaatgtcatt atgcggttgc ataactgtat ttattgttat gttctttttt     8280

ggactgtttt tatattttgg attatacttt ggaaaaatta ctgagcctct cttgagctcc     8340

agtttccttc tctttgagat gggacaaata ataggaccta caccataggg tgctacttca     8400

ctggattgtg tgggagagta catgcggagc cctagtatgt tctttccttt acttgtacaa     8460

ctcaccagga tgacagctgt catgaataaa gagtgtgctt tgccctgccc aactacaagg     8520

tcccactacc agttgaggag tatactctga ttcattgtga aaatgccaac aagggtggtt     8580

atcccttgct ggaaagcagg ttaaaaggat tttcataatt ctgtacctct tctctttcct     8640

ccaggcctac tctgtgaaga gaacattgat gactgtgccc ggggtcccca ttgccttaat     8700

ggtggtcagt gcatggatag gattggaggc tacagttgtc gctgcttgcc tggctttgct     8760

ggggagcgtt gtgagggaga catcaacgag tgcctctcca acccctgcag ctctgagggc     8820

agcctggact gtatacagct caccaatgac tacctgtgtg tttgccgtag tgcctttact     8880

ggtgagaagc tctctagcct cctggccact ctgccttgga ggatggtttt agtgaacaaa     8940

ttgggccctg tgagttgtcc cagacccaag tgaagctttt cttatataag aaaaacaaca     9000

gcagcttaat tttttaaagc cagttttttc ttagtctgta ctttatggat gttatgatca     9060

gtgtctacct ttaatttttc ctaagagatt cttttgttgt gcattgatta tatcatgcta     9120

tggcaggaat attttttaca atgtatattg aaagtagttg aacaaaataa cattttttaa     9180

tagtggcaaa atatccaaaa cctaaaattt actatctgaa tcattttaaa gtgtacagtg     9240

tacagttcag tggcattgtt tagtacattg acattgttgt tctactatca cccccattca     9300

ttcacagaac tcttttcatc tgaacaaaat aacattttgt tttaaggaac cttacgtcta     9360

actccggttt cttcaccctg cctcctttga catgtgatgg cttgaattac tgggtagttc     9420

ctgccaccat gatctttcca cccctaggac tcagagaagc ttaggaccct gcttagatac     9480

ttaaaggggg caggtccaaa ttcaagtgtg tttaaccaaa gatcagttga tgtgggtatg     9540

aaatgaaaag ttgcagtggt cacaagtaat gccttgccca gtaaaggctt ggccatgttc     9600

ctactctgtt cccaagcttc tttctttcat cacagggcct gaagatgacc aagctctgcc     9660

tcagaatagg ggtcttatca caagaactta ctagttactt ctggagaggg cagcatggtg     9720

acttttggga actaaaatag ttgtttgtat ccagatgtgg caggatactc agatttgaaa     9780

tttatcatgc atttcctggg gtctgtagtt gtatttctta tatggagggt gtgatcagat     9840

tccttaggag tcagaaaata ggctttaata gtctgtttac aaacaattca tcaagctgaa     9900

ctctgctaca tcctgagccc atctccagcc atctttcctt ccaactttaa agatatgcta     9960

ccttacaatc ttggaatttt gtaaagaatg ggagggattc tgcaatatgg aagctccctg    10020

gatacactaa catcaaaaaa gaaatagtcc attgtgaaca taatagctat tgaggcaatg    10080

tggaacagaa taagtatgaa taatctgtct acagcctcgt attggccaaa ctgcactttg    10140

aaagccaaag catcaaaact ggctcctgtt tctttcattg cccctgaggc ttttttctct    10200

ggaaacacaa gcatttgcaa agtaaggggg aagcaggaga aggaaggaat ggagaccact    10260

ttgaagtagt atcccacagc caggaagtag tgtttgtgca ttttccacat ttgtgaatga    10320

aaaaaaaaaa atcccttgaa tacattgagc acagttattg tgggatgctg ttgcagagat    10380

aaacagcaag ggactggtgg tccaccaagc tgtgtccatg tggtggctgc tcttggttag    10440

cggctgctgc tgtgatttga agagacaaac atttatacct cttgctgctt gatctcgttg    10500

gccaaaaaca ttactatttt tatttcattt ttaaagctac ctcttctttc ccaagtgacc    10560

accggccaaa tggggcctat ctcctgctgt tggccaggag tcccagctgt gccctgcgtc    10620

tcctctgtgg ttccagttgc ctcgttcttt atcttggagc agtggccccc aggggccttc    10680

cgttttagaa ctattcctag aggaaactaa ctctaggaaa attaagctgt gttttaagga    10740

atacgagtta ggttacagaa aggccaaaaa gtgattgaaa tgaggtatca cagatgaaaa    10800

ttctctatac cgcaaatcac catttaaatg tattggcctg gtgtagcctc tcctatgaag    10860

tagataacat taacaaaatg cagtgaatag tttttcaact gtttttttgc aacttatgaa    10920

agctaaaatg acttcaaaaa gctgaagtgt gatttctctt tttttgatgg gatttaagtc    10980

acttttctca cccaccctgt tgtgtgagtt ggtacttact gtgtaggcaa gacagagtaa    11040

gggactggcc tgagctggtg acaggccaat catgttgaga tgcagtgagt gttttctttc    11100

tatgctcaga ttaccacagg cctagaactg aactctctca cacttgcttc acctatggct    11160

agttcccatc ccagcaaagt ttgttgagta acttgcagtg actacttctg ccttttaaaa    11220

ccttttttat tttttatttt ctgaggccgg cactgtgaaa ccttcgtcga tgtgtgtccc    11280

cagatgccct gcctgaatgg agggacttgt gctgtggcca gtaacatgcc tgatggtttc    11340

atttgccgtt gtcccccggt aagtgccctg ttgctcatct aagaaggggc attgtctctt    11400

ccatacaatc tgtgaacaga actgagatta aacctggttt taccaatctt cgaaatggga    11460

agatttctca attttagctc tttcagagga aagtgcttgg gtttttccat ttaaagctgt    11520

ttacaagtga caaaacaaaa caaaaacaaa taaaagctgt ttagacactc ccagaaacag    11580

tgagcttccc aatccatgac tgtcagtctt aagaaaaact aagggaaaac cacaaaaagt    11640

ggtggagtgc ccccttgaaa atagggctga tgtgtggggc ttcttggccc caggctggag    11700

ggtaatctca ctgcccagat tgggccagag ttggtggaaa tgctgctctt acattcttta    11760

gcaggaacca tttggaagca agttgtctct taaagtagag ggaagctcaa ttttagctat    11820

ttgctatacc cattctttta tcactgccag aggttgaaac cttcccaaaa caagagatcc    11880

ctatgcctcg ggagatacca aaaggaaacc tgtctagtaa ccttggcttg ggctgaacgg    11940

gaagtacaga agggagtgag atgtggaggt tttctagaaa cctcaaactt ccaatatgac    12000

tgttttccta ccaatgccat ttttatttcc tcactgattt ccacagggat tttccggggc    12060

aaggtgccag agcagctgtg gacaagtgaa atgtaggaag ggggagcagt gtgtgcacac    12120

cgcctctgga ccccgctgct tctgccccag tccccgggac tgcgagtcag gctgtgccag    12180

tagcccctgc cagcacgggg gcagctgcca ccctcagcgc cagcctcctt attactcctg    12240

ccagtgtgcc ccaccattct cgggtagccg ctgtgaactc tacacggcac cccccagcac    12300

ccctcctgcc acctgtctga gccagtattg tgccgacaaa gctcgggatg gcgtctgtga    12360

tgaggcctgc aacagccatg cctgccagtg ggatgggggt gactgttctc tcaccatgga    12420

gaacccctgg gccaactgct cctccccact tccctgctgg gattatatca acaaccagtg    12480

tgatgagctg tgcaacacgg tcgagtgcct gtttgacaac tttgaatgcc aggggaacag    12540

caagacatgc aagtaagggc ttcacgtttt ccagaactga aggggactgt cactaacaca    12600

cttcagtttc tcgttcttgc tcctaaccac tccagtgctt cagcctaagc tgcctctgct    12660

tttcagatgg tgccagcctt gtcccatcgc acactgccct gtgctctccc ttgctgacaa    12720

tgggccagga atgctcattg cataatgacc ctctctctct gcctatcttt gccttctcac    12780

ctgctgcctt cgtgacctcc tgggggatat aacttttgga agtggtgttt cccacttcaa    12840

gcagcctctc acataacctg cctgcaggat ggatggaaag gtctgtatct ctctcttcac    12900

cccattcctt tccctaagac tgtttttccc catctagatt tatcaggaag catgaattag    12960

attaagtctg tgaaccctcc cggtcttaat tgtataggat gctctatggt ttacttagga    13020

actttcctat taactagcca ttccatataa tttaatccca attaattctc agcaactcac    13080

gaggcatagg tattactaac attctttcat aggtgagaga acttaggccc aagggttaaa    13140

gaacttgcca aagcaagttg tttctttgac tcctaatctt ctgattgagc tagcatgaaa    13200

agttgtacca aatagtataa atatcaaggg gtaggggatg aggagaggag agtatagatg    13260

gaatagtttg tacatcattt aggtttgggg gttctaattc cttttccaaa tattgaaaga    13320

gcctgtacaa gtaatatctg gtgtgctata aggacatacc catctgcctt taccttctgt    13380

agttgggatt cactcttgaa agggaaagaa atgggtcatg ttaatattgt tctctgtatg    13440

gcaactctca atggttcagg gccttgtatc aagtttctag aggcatcttt cacttcctaa    13500

agcccgttgt taccttactg ggggcaatgg atttctctaa agtagaggaa gcatgaacca    13560

ggttgacttt tgtttcagat atgcagcttt gtttgaaaac ctgacttaac aggcttgtaa    13620

actgcctggg agcccctaag ctcctgcagc atagtgagta caatgttctt catttaggaa    13680

gtactcaaca aggatgagtg gcataggcat cagggatagg agatgcaaag aaggttttgt    13740

ggggcatttg ggtcctgggt gtgggccaca gaaaatgggt aggaaaatcc acagtagttc    13800

caaatgaaaa agcaaataga gctccagtct aatctgagct cttttgcctg ttctctgctt    13860

ccccttacct aggtatgaca aatactgtgc agaccacttc aaagacaacc actgtgacca    13920

ggggtgcaac agtgaggagt gtggttggga tgggctggac tgtgctgctg accaacctga    13980

gaacctggca gaaggtaccc tggttattgt ggtattgatg ccacctgaac aactgctcca    14040

ggatgctcgc agcttcttgc gggcactggg taccctgctc cacaccaacc tgcgcattaa    14100

gcgggactcc cagggggaac tcatggtgta cccctattat ggtgagaagt cagctgctat    14160

gaagaaacag aggatgacac gcagatccct tcctggtgaa caagaacagg aggtggctgg    14220

gtaggtgttt ggtttctgaa cttcaaggct aattttatga agcctagcac tttgacatat    14280

agcacaagtc ataactcaac ctatagaaat gcaaagatca gaaaaataga atggcccacc    14340

acttaagata aacccgttac cccagtactt acgtttaaat gtaaagatat gccttcgtct    14400

tggctgaaaa gtgggcaggg gtacacagga ggcagaatgt ctggaaggcc tcctcagatg    14460

ccagaatcca taaccttttg ccagagttgc ctcaaatccc tttattagtg acattccttt    14520

ttacattaat cattgcctta ttgttaaggc ccttctttag aatatatgtc tctttgacac    14580

aggtaatgat cttcagttgc tctgtcattc acacctcact ctttgttggt atattgtcaa    14640

actttcaacc ctccagctag ctgagatacc aatgcagaga caaaggaaaa taaggactaa    14700

aaacacacag ggatgtatgt ttagagtagc accaagtacc actgagtagg tatgaaagag    14760

tggaagaaga ccactgaaac cttcgggagg aaagcacagc ttctcacttt gtcatgcatt    14820

gcctcagcca gaaggctttg gtcagccaga ctaaggaagg tgggacatcc tctatgtggg    14880

aattagtgtt taagatctca agggacagta ttctaattcc tgagatatgt cttaaggcag    14940

catcccagag gtggggacct gatgctgaag gggaggaagg gaggctcctg tcacccttta    15000

tgacatgttc tgcctgacct gcactcttct gttttacccc catctctcct cctccgcttc    15060

tcccttggca tcccacagct ctaaagtctt tctggaaatt gacaaccgcc agtgtgttca    15120

agactcagac cactgcttca agaacacgga tgcagcagca gctctcctgg cctctcacgc    15180

catacagggg accctgtcat accctcttgt gtctgtcgtc agtgagtggc actggtgtaa    15240

aggggaaagg tggcggggga agagtgtcaa ttgggggaac aattttcatt atgtagccct    15300

ctattttttc aggactgttg aggtcaaagt tgccctctaa atgaatctaa tgctgacatt    15360

gagaggttaa tgttttattc agcactttcc ctgtctctgt ggactttcag gtgaatccct    15420

gactccagaa cgcactcagc tcctctatct ccttgctgtt gctgttgtca tcattctgtt    15480

tattattctg ctgggggtaa tc                                             15502


<210> 3
<211> 2627
<212> DNA
<213> Homo sapiens

<220> 
<223> NOTCH2 minimal deleted region

<400> 3
gccggcactg tgaaaccttc gtcgatgtgt gtccccagat gccctgcctg aatggaggga      60

cttgtgctgt ggccagtaac atgcctgatg gtttcatttg ccgttgtccc ccggtaagtg     120

ccctgttgct catctaagaa ggggcattgt ctcttccata caatctgtga acagaactga     180

gattaaacct ggttttacca atcttcgaaa tgggaagatt tctcaatttt agctctttca     240

gaggaaagtg cttgggtttt tccatttaaa gctgtttaca agtgacaaaa caaaacaaaa     300

acaaataaaa gctgtttaga cactcccaga aacagtgagc ttcccaatcc atgactgtca     360

gtcttaagaa aaactaaggg aaaaccacaa aaagtggtgg agtgccccct tgaaaatagg     420

gctgatgtgt ggggcttctt ggccccaggc tggagggtaa tctcactgcc cagattgggc     480

cagagttggt ggaaatgctg ctcttacatt ctttagcagg aaccatttgg aagcaagttg     540

tctcttaaag tagagggaag ctcaatttta gctatttgct atacccattc ttttatcact     600

gccagaggtt gaaaccttcc caaaacaaga gatccctatg cctcgggaga taccaaaagg     660

aaacctgtct agtaaccttg gcttgggctg aacgggaagt acagaaggga gtgagatgtg     720

gaggttttct agaaacctca aacttccaat atgactgttt tcctaccaat gccattttta     780

tttcctcact gatttccaca gggattttcc ggggcaaggt gccagagcag ctgtggacaa     840

gtgaaatgta ggaaggggga gcagtgtgtg cacaccgcct ctggaccccg ctgcttctgc     900

cccagtcccc gggactgcga gtcaggctgt gccagtagcc cctgccagca cgggggcagc     960

tgccaccctc agcgccagcc tccttattac tcctgccagt gtgccccacc attctcgggt    1020

agccgctgtg aactctacac ggcacccccc agcacccctc ctgccacctg tctgagccag    1080

tattgtgccg acaaagctcg ggatggcgtc tgtgatgagg cctgcaacag ccatgcctgc    1140

cagtgggatg ggggtgactg ttctctcacc atggagaacc cctgggccaa ctgctcctcc    1200

ccacttccct gctgggatta tatcaacaac cagtgtgatg agctgtgcaa cacggtcgag    1260

tgcctgtttg acaactttga atgccagggg aacagcaaga catgcaagta agggcttcac    1320

gttttccaga actgaagggg actgtcacta acacacttca gtttctcgtt cttgctccta    1380

accactccag tgcttcagcc taagctgcct ctgcttttca gatggtgcca gccttgtccc    1440

atcgcacact gccctgtgct ctcccttgct gacaatgggc caggaatgct cattgcataa    1500

tgaccctctc tctctgccta tctttgcctt ctcacctgct gccttcgtga cctcctgggg    1560

gatataactt ttggaagtgg tgtttcccac ttcaagcagc ctctcacata acctgcctgc    1620

aggatggatg gaaaggtctg tatctctctc ttcaccccat tcctttccct aagactgttt    1680

ttccccatct agatttatca ggaagcatga attagattaa gtctgtgaac cctcccggtc    1740

ttaattgtat aggatgctct atggtttact taggaacttt cctattaact agccattcca    1800

tataatttaa tcccaattaa ttctcagcaa ctcacgaggc ataggtatta ctaacattct    1860

ttcataggtg agagaactta ggcccaaggg ttaaagaact tgccaaagca agttgtttct    1920

ttgactccta atcttctgat tgagctagca tgaaaagttg taccaaatag tataaatatc    1980

aaggggtagg ggatgaggag aggagagtat agatggaata gtttgtacat catttaggtt    2040

tgggggttct aattcctttt ccaaatattg aaagagcctg tacaagtaat atctggtgtg    2100

ctataaggac atacccatct gcctttacct tctgtagttg ggattcactc ttgaaaggga    2160

aagaaatggg tcatgttaat attgttctct gtatggcaac tctcaatggt tcagggcctt    2220

gtatcaagtt tctagaggca tctttcactt cctaaagccc gttgttacct tactgggggc    2280

aatggatttc tctaaagtag aggaagcatg aaccaggttg acttttgttt cagatatgca    2340

gctttgtttg aaaacctgac ttaacaggct tgtaaactgc ctgggagccc ctaagctcct    2400

gcagcatagt gagtacaatg ttcttcattt aggaagtact caacaaggat gagtggcata    2460

ggcatcaggg ataggagatg caaagaaggt tttgtggggc atttgggtcc tgggtgtggg    2520

ccacagaaaa tgggtaggaa aatccacagt agttccaaat gaaaaagcaa atagagctcc    2580

agtctaatct gagctctttt gcctgttctc tgcttcccct tacctag                  2627


<210> 4
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 4
Met Val Tyr Pro 
1               

<210> 5
<211> 4
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 5
Met Ala Lys Arg 
1               

<210> 6
<211> 1377
<212> DNA
<213> Homo sapiens

<220> 
<223> NOTCH2 between START1 and START2

<400> 6
gtgtacccct attatggtga gaagtcagct gctatgaaga aacagaggat gacacgcaga      60

tcccttcctg gtgaacaaga acaggaggtg gctgggtagg tgtttggttt ctgaacttca     120

aggctaattt tatgaagcct agcactttga catatagcac aagtcataac tcaacctata     180

gaaatgcaaa gatcagaaaa atagaatggc ccaccactta agataaaccc gttaccccag     240

tacttacgtt taaatgtaaa gatatgcctt cgtcttggct gaaaagtggg caggggtaca     300

caggaggcag aatgtctgga aggcctcctc agatgccaga atccataacc ttttgccaga     360

gttgcctcaa atccctttat tagtgacatt cctttttaca ttaatcattg ccttattgtt     420

aaggcccttc tttagaatat atgtctcttt gacacaggta atgatcttca gttgctctgt     480

cattcacacc tcactctttg ttggtatatt gtcaaacttt caaccctcca gctagctgag     540

ataccaatgc agagacaaag gaaaataagg actaaaaaca cacagggatg tatgtttaga     600

gtagcaccaa gtaccactga gtaggtatga aagagtggaa gaagaccact gaaaccttcg     660

ggaggaaagc acagcttctc actttgtcat gcattgcctc agccagaagg ctttggtcag     720

ccagactaag gaaggtggga catcctctat gtgggaatta gtgtttaaga tctcaaggga     780

cagtattcta attcctgaga tatgtcttaa ggcagcatcc cagaggtggg gacctgatgc     840

tgaaggggag gaagggaggc tcctgtcacc ctttatgaca tgttctgcct gacctgcact     900

cttctgtttt acccccatct ctcctcctcc gcttctccct tggcatccca cagctctaaa     960

gtctttctgg aaattgacaa ccgccagtgt gttcaagact cagaccactg cttcaagaac    1020

acggatgcag cagcagctct cctggcctct cacgccatac aggggaccct gtcataccct    1080

cttgtgtctg tcgtcagtga gtggcactgg tgtaaagggg aaaggtggcg ggggaagagt    1140

gtcaattggg ggaacaattt tcattatgta gccctctatt ttttcaggac tgttgaggtc    1200

aaagttgccc tctaaatgaa tctaatgctg acattgagag gttaatgttt tattcagcac    1260

tttccctgtc tctgtggact ttcaggtgaa tccctgactc cagaacgcac tcagctcctc    1320

tatctccttg ctgttgctgt tgtcatcatt ctgtttatta ttctgctggg ggtaatc       1377


<210> 7
<211> 14276
<212> DNA
<213> Homo sapiens

<220> 
<223> NOTCH2 exon 20 to last nucleotide upstream of START1

<400> 7
accctggtga atctctgcag tcggtctcca tgtaaaaaca aaggtacttg cgttcagaaa       60

aaagcagagt cccagtgcct atgtccatct ggatgggctg gtgcctattg tgacgtgccc      120

aatgtctctt gtgacatagc agcctccagg agaggtaagc tttgctccct tgggctcagg      180

tcattcactg cagtattgac tgtccagtgg catttagaga aggtatcatt tttttgtgga      240

ataagaggga agggcagata gtagtgggtg ggcagggctc tggggaaagg gctcaagaca      300

gaaggtgtaa gggtagagga ataggttcag agattcggag aagaatgtat ttgaaatgaa      360

actaaggtat attccacttt cagggtttat ttttaatatg catctggtac tgagggttgt      420

gaagaactgg ctaagaataa gattggatgt gtcagccagt ttagatttac ttgctcattg      480

gttgatttga accccatgtg tcacatgttc ttctatgaca tttctccctc actgggtttc      540

ccaggtgtgc ttgttgaaca cttgtgccag cactcaggtg tctgcatcaa tgctggcaac      600

acgcattact gtcagtgccc cctgggctat actgggagct actgtgagga gcaactcgat      660

gagtgtgcgt ccaacccctg ccagcacggg gcaacatgca gtgacttcat tggtggatac      720

agatgcgagg tgaggacact gagcaagcag aggtcatgga cctcccagga gattgtacaa      780

ctgtttgagc actgatatat tgaatttagc tgcttgtatc ttatattgat agtttataga      840

tttttaccaa tccccgtcat aatgtttacc actgtttctt tcagcctctc tgtgcaataa      900

gttaacaggt ccctagtatg atatttttat aggcgtctgg aaccatccca gctccttagg      960

cttgctttta ggattcagag ccaagagtca ctaccagagt gcattttaca ggcccaccca     1020

acatagcagt ccacacttcc ctgaatagca gctgagatag gaaaaactgc tttgtggagt     1080

gtccctttgg cccctgtcac ctttgtattt agtcattaat cagtcaacta gcaattttct     1140

ctcaaaaaaa aaaaatgttg ctcatcctgt tccccatagc atcatgctaa acgttacatg     1200

tatatatttg aggaagtatg tgtcttcaag gtacatgtca ctattttaat gtctgggctg     1260

ataatggtta gagcaagcaa gatattagca aaatgcctga gacattaatt tgataccaat     1320

tcaaaccatc aagcaacact gagaaaagct ttgcttctct attgttatat aaatgagcca     1380

acgatagctt ctgtattttg gcccctaggt tgtttatttc ttcacagcag gctggggctg     1440

ggtctcatta gctcaaaagc ctaccagtgc caaacccaaa ttttgacaca tctagttgtt     1500

ttaaacatag cccccaaata agcagatttt tagctattta gagcttgcct gctttgcata     1560

gcctgtaaaa ctgcagccaa aatctgctag ccatagtata agtaggacaa gatataccct     1620

ggggccatac agaccccagg ctgatgctgg cctttagagc tctctgaccc agagattcct     1680

gccactggct gttgagtgac atcacctaga ctccttctct gatccttctt tcccagagtt     1740

tacttgctgt cttcccctta ctcacctacc cctctggaag gtctcatgct atttgggact     1800

tctcccaggt gcaaacctgt caaagtgtcc aaataaagcc acctcacagc catatctttt     1860

ttcttggtca gccctgaaat ccttccaacc cctacagcca ccacagccag ccagccagcc     1920

ccacctccct ctacccctaa gcctatctca accagtttct cacacataga tccaatttcc     1980

taaacctgga gatcaataat tgcatgtctg tactaccatc cacatatgcc ttttgaccga     2040

gtcatagggt cctcatcaca tacggaggaa tgtgtatttt aaagatgagg aaacctgtac     2100

ccaggaggaa caaaaggttt gcacacaagt caaatctgaa acatccttca ttgtattcag     2160

tccttgcctt ccctttaaag tgcctttttc aactgaaaga ggagtaggta aatgccagta     2220

agctgcaggt tttctgtccc tgcatagaat gattagcaga gagtgtgatg gttccagaga     2280

aaacatacaa aagctaaatt aggaggtggg agacagtcac agaaatgttc cagatctcac     2340

tagctctcat ggtctgtttc cagtaatggt ccaatatttc ttgtcctttt tgtttcctca     2400

tggcagtgtg tcccaggcta tcagggtgtc aactgtgagt atgaagtgga tgagtgccag     2460

aatcagccct gccagaatgg aggcacctgt attgaccttg tgaaccattt caagtgctct     2520

tgcccaccag gcactcgggg tatgaaatca tccttatcca ttttccatcc agggcattgt     2580

cttaagttat aaatccattc ttagtgttca ggggatttta taaaattaaa gataggaaga     2640

ctagcttcat tccaagcatt tagttctaca tcctagtaat tcaagccatt ttattctccc     2700

atctcttgct agctctgatg ttgtggttta tgttgtcagt tttatctggt tgtttggcat     2760

cttgatattc catgaaacac agaatatgga agggatacaa cattagcata acattaaaaa     2820

attagcctgg tcagtaagat ttcttgttgc ttcacagaaa agcaactaat ggcctctaaa     2880

ataaacaatt tacatttacc tgcttttgta tttttttaat tagccaagtc ttacctctat     2940

aaggtggggg aatgaatgaa atgaaaatat ctgcctattt tcatagcttc aggggaggat     3000

actgatggtg taaggttcta ccttaggatg cagtaaggcc tgatgagaga tgcaaccctg     3060

gactgttgag tgatggggcc atcattcttc tgtgggcatt gccactgctt ttgaactgag     3120

tggtatggcc atcattctgc tgtggacatt gacactgctt ttgaaccatc ccttggaaag     3180

agctttgagt attgtttgtt agaagggatg tagttatgct ggggcctact ctgagaaggc     3240

tgtgaaaaaa atgtaaaagg ccatccacac tggtgagaaa ttcatccttg ttagtgtcaa     3300

agagaataga atgccagaga agtatttgta ttgccttaga gctttgtgtc agtaaagttt     3360

gataatttgc caccccaggt atcagagttt gactaaatta aaataggaga gtaccctagt     3420

agtaggctga ttattaagga atgaggttaa tgggaagaag aaaactaagg agaaacagtc     3480

tttaagtatt tgaagaattg tcctgtaaaa aggagaattg ttctttattc tagaaatcag     3540

tggttgagta gaaattaatt ccagttcatt gttagtttgt tcctttgaga aactgtactg     3600

gttaggacaa gctacgattc tggtgatagc tgttatcgta gttcatttat gttgctataa     3660

aagaatacct gagactaagt aatttatttt tcgaaagagg tatatttggc tcgcagttct     3720

ataggctgta caggaagcac ggtgccagca tctgcctctg gtgtgagcgt caggctgttt     3780

ccactcatgg tgaaaagtga agaagatcca gggacccaaa cacctcccat taggccccac     3840

ctccaacatt ggagatcaca ttttaacatg tggtttggtg cagtcaaact tcaagctata     3900

gcagctaatt aaacctcaaa tctcagagct taatataaca ctgattttgt cactcaaata     3960

aagtcgaata tgtgttgggc tacctttctc tgtgttttag atatgtggtt tgaaacacct     4020

ggcctccaag gcctccacag tacagggaag agggacagac ttgaagggtc atacagcagc     4080

ttccactagc tcagtctgga agcaacacat atcactatcc ctcgcagtat attgaccgga     4140

attattaaat ggtctctgtg acttcaaggg aggctgggaa atataggaga gtacatgagt     4200

attcatcaaa ctctaaaatc actactatac catgaacttt taattaataa gacatgtcca     4260

gtcctagaat ggatcatttc agaaggaaac aaaatttttg tctcttctaa ccatatggta     4320

aagatggctt agaatactag ttttgatatt atcattgaca gtctttttct ttcagcactt     4380

tgaatatatc atcccactgc tttctgatat ccatggtttt taatgagaaa tatgctgtta     4440

atcttattga ggttccctta tatgtgatac attgcttctt tcttgatgcc ttcaagattc     4500

tttatctttt gatagtttga ttatgatgta tgtaggtatg aatttctttg agtttatcct     4560

acttacagtt ccttggatta ttttactgtg tgtgcttgtt taggtatgtg gaacagtatt     4620

tttttatcct gacttaactt ctctggccat tggtaaacat tccaggaaac tctcaagtcc     4680

cataacccca ttgttagagt catcacaatg tgtgttttgg tcaccatatt tctaagcctt     4740

agatctttgc ctgcatgtcc caccagtttc ccaggtcaag ggctaaatgt aacagttctg     4800

cctcttccta ctactttgct tcaggctgag gttgagttct ctctcagttg atagatctgt     4860

ttatttctgg tggttccatt ctgatgggga aatatgcatt tatgctcatt ttactagcaa     4920

tccctaaata tcaaatattc tttgagacag ggagcatata ctagattttg tttgttttta     4980

cttttttgtt ttcaatttac tctatgtata aggtgatata tgcatatatg catatagacc     5040

aaaagtgtat tcacacatag aaaagtatac agtgaaaata cttctcattc ccatctctct     5100

tctggtgggc aaattttccc tctcctgcaa acatgtaatc gccacttttg gttgtttgtg     5160

tttctttcta gaatttttca aaaactgtat ccttcagaat ttctttatgt agagagaagc     5220

caaatgcaaa gatattttat ttcctttact ttttactctg aagatagaat attagacaca     5280

ttttttgcac ttgatttttt tttacttaat tggagatatt ttcatatcaa aatatagaac     5340

ttcctctctc tctctctgag atagatagat agatagatag atagatagat agatagatag     5400

atatttgttt gtttgtttgt tttgagatgg agttttgctc ttgttgccca ggctggagtg     5460

caatggtatg atctcagctc accgcaacct ccgcctcctg ggttcgagtg attttcctgc     5520

ctcagcgccc tgagtagctg ggattacagg catgtgccac catgcctggc tgattttgta     5580

tttttaatag agacagggtt tctccatgtt ggtcaggctg gtcttgaact cctggcctca     5640

agcaatccac ccgcctcagc ctcccaaagt gctgggatga caggcgtgag ccaccacacc     5700

cagcctgaac ttcctcaata ttttttatag ctacagaatt cccttttaca ggcataccat     5760

attttaacca gtgccatcat gatagatatt tcagttatct tgcaggcata taagtatatt     5820

ggtgaaataa attttcagaa atagaatcgc tggattggat aatatgtgca tttatcattt     5880

taatcagtga ttgcagtata tcagcatatt ggctttttct taaggtggag aatatatttt     5940

catttaagaa tcattttctt ttgatttttt ttgcagtttc tttgtttata tatatatata     6000

tgtatatata catatatata tatatacaca catatatctt ttttcccaca ttaagttgtt     6060

gatgtaatgt tttgtggaaa ttggctatga tataaaaaaa caaatatatt cccagtattt     6120

ttttatcttt tttctttata gtgattttta gtgcacactt ttacttttta atcaagttga     6180

atttatcact tttaaaatgg cttctggatt ttgagttgta gttagcaaca tcatatacac     6240

ttgaagatcg taaagaaatt ctcccatatt ttcttcaagt acttttgcca tatgactact     6300

catttgttaa tacacaattt attgaatatt ttgtttttta tatatataat gatttgagat     6360

ggcacctttg ccagattcta aattcccatg tgtatttttg gtgttcttct ggattttctt     6420

tattttctgt gttattctat taattcacca ataacgttct atttcaatta ttaaggatct     6480

tcttcttcat agttttcctg gttatttttt ttcacataat tttataatca gcttgtctgt     6540

taataaattc ctgttgataa tttttagtgg ggtctcatta aatttatgaa ttatagtata     6600

gagaaaactg ataactttat gatgaggagt cttgctaacc aaatcctggt atgtctttcc     6660

atttattcaa gtctcttttg tgtctgttag gacagtatta aagttgtctt catttaggtg     6720

taacacattt cttgtgaaga ttgttcctag gtattttatc tttggtaatt tggtaattgc     6780

ttttgaaaat tgggccttac tttacattta aaaaaaaaaa tcttgctttt gttagtgtat     6840

gctacaatgc aagtggcagg aatacataca gaactgtttt cttttgtacc tttttttttt     6900

ttttttttaa gacagagtct tgctctgttg cccaggctgg agtgcagtag cgcaatctcg     6960

gcttactgca agctccacct cccaggttca tgccattctc ctgcctcagc ctcccgagta     7020

gctgggacta caagcgcccg ccaccatgcc tggctaattt tttttttgta ttttttagtg     7080

gagacggggt ttcaccatgt tagccaggat ggtctcgatc tcctgacctc gtgatccacc     7140

tgccttggcc tcccagagtg ctgggattac aggcttgagc cactgcaccc agcctgtacc     7200

ttttttttta attatgatta ttattatttt ttgagacaga gtcttgctct gttgcccagg     7260

ctggagtgca gtggcataac ctcggctcac tgcaagcttc atctcccggt ttcaagtgat     7320

tctcctgcct cagcctccca agtagctgag attacagaca tgtaccacca cacgcagcta     7380

atttttgtat atttagtaga gatggggttt cactgtgttg ggcagattgg tcttgaactc     7440

ctgacctcaa gtgatccgcc tgccttagcc tcccaaagtg ctgggattac aggtgtgagc     7500

cactgtgccc agcctctttt gtgccttttt gaattaatca tagaataatt tctagaatag     7560

tcattgattt cttttgtttc tttgtaagac actatatgca gatattcata ctagatggct     7620

catttacatc tatagtacaa taaattagtc ctgttttaaa tggaataact tttgaactct     7680

cagcaggaaa tttatcctct atttttgtta aataaaaagc attggtgcac ttatacacta     7740

ttacagaaaa aagccagtga ttataaaact taaaaatgta tttcattcaa aattcagttc     7800

cagttgttac caatattttt acataaccta tgtatagtca tgggtcactt aacagtgggg     7860

atatgttctg agaaatatgc ccttaggcaa tttcattgtt gtacaatcat catggagtgt     7920

aattacacaa acagagagag tatggcttac tacacaccta ggctccaaac ctgcaccttg     7980

ttttactgaa ctgaatattg taggcaatta taacacaatg gtaagtattt atgtgtctga     8040

acatatttaa gaagaggtac agtagaagat ttaaaaggta cagtaaaaat acaatataaa     8100

agataaaaaa tagtacacct gtatagggca tttactatga aaggagcttg caagactgga     8160

acttgctggg tgagtcagtg aatggtaagt gaatgtgaag gcctaggaca ttactgtaca     8220

ctactgcaga ctttgtaaat actgtacacc taagctacac tgaatttatt taaaaagtaa     8280

ttgtgctatg acattacaag gctatgatgt tactaggcaa caggaatttg tcagcttcag     8340

cttcattatg ggaccactgt cgtatgtgct gcctgcattg actaaaatgt cattatgcgg     8400

ttgcataact gtatttattg ttatgttctt ttttggactg tttttatatt ttggattata     8460

ctttggaaaa attactgagc ctctcttgag ctccagtttc cttctctttg agatgggaca     8520

aataatagga cctacaccat agggtgctac ttcactggat tgtgtgggag agtacatgcg     8580

gagccctagt atgttctttc ctttacttgt acaactcacc aggatgacag ctgtcatgaa     8640

taaagagtgt gctttgccct gcccaactac aaggtcccac taccagttga ggagtatact     8700

ctgattcatt gtgaaaatgc caacaagggt ggttatccct tgctggaaag caggttaaaa     8760

ggattttcat aattctgtac ctcttctctt tcctccaggc ctactctgtg aagagaacat     8820

tgatgactgt gcccggggtc cccattgcct taatggtggt cagtgcatgg ataggattgg     8880

aggctacagt tgtcgctgct tgcctggctt tgctggggag cgttgtgagg gagacatcaa     8940

cgagtgcctc tccaacccct gcagctctga gggcagcctg gactgtatac agctcaccaa     9000

tgactacctg tgtgtttgcc gtagtgcctt tactggtgag aagctctcta gcctcctggc     9060

cactctgcct tggaggatgg ttttagtgaa caaattgggc cctgtgagtt gtcccagacc     9120

caagtgaagc ttttcttata taagaaaaac aacagcagct taatttttta aagccagttt     9180

tttcttagtc tgtactttat ggatgttatg atcagtgtct acctttaatt tttcctaaga     9240

gattcttttg ttgtgcattg attatatcat gctatggcag gaatattttt tacaatgtat     9300

attgaaagta gttgaacaaa ataacatttt ttaatagtgg caaaatatcc aaaacctaaa     9360

atttactatc tgaatcattt taaagtgtac agtgtacagt tcagtggcat tgtttagtac     9420

attgacattg ttgttctact atcaccccca ttcattcaca gaactctttt catctgaaca     9480

aaataacatt ttgttttaag gaaccttacg tctaactccg gtttcttcac cctgcctcct     9540

ttgacatgtg atggcttgaa ttactgggta gttcctgcca ccatgatctt tccaccccta     9600

ggactcagag aagcttagga ccctgcttag atacttaaag ggggcaggtc caaattcaag     9660

tgtgtttaac caaagatcag ttgatgtggg tatgaaatga aaagttgcag tggtcacaag     9720

taatgccttg cccagtaaag gcttggccat gttcctactc tgttcccaag cttctttctt     9780

tcatcacagg gcctgaagat gaccaagctc tgcctcagaa taggggtctt atcacaagaa     9840

cttactagtt acttctggag agggcagcat ggtgactttt gggaactaaa atagttgttt     9900

gtatccagat gtggcaggat actcagattt gaaatttatc atgcatttcc tggggtctgt     9960

agttgtattt cttatatgga gggtgtgatc agattcctta ggagtcagaa aataggcttt    10020

aatagtctgt ttacaaacaa ttcatcaagc tgaactctgc tacatcctga gcccatctcc    10080

agccatcttt ccttccaact ttaaagatat gctaccttac aatcttggaa ttttgtaaag    10140

aatgggaggg attctgcaat atggaagctc cctggataca ctaacatcaa aaaagaaata    10200

gtccattgtg aacataatag ctattgaggc aatgtggaac agaataagta tgaataatct    10260

gtctacagcc tcgtattggc caaactgcac tttgaaagcc aaagcatcaa aactggctcc    10320

tgtttctttc attgcccctg aggctttttt ctctggaaac acaagcattt gcaaagtaag    10380

ggggaagcag gagaaggaag gaatggagac cactttgaag tagtatccca cagccaggaa    10440

gtagtgtttg tgcattttcc acatttgtga atgaaaaaaa aaaaatccct tgaatacatt    10500

gagcacagtt attgtgggat gctgttgcag agataaacag caagggactg gtggtccacc    10560

aagctgtgtc catgtggtgg ctgctcttgg ttagcggctg ctgctgtgat ttgaagagac    10620

aaacatttat acctcttgct gcttgatctc gttggccaaa aacattacta tttttatttc    10680

atttttaaag ctacctcttc tttcccaagt gaccaccggc caaatggggc ctatctcctg    10740

ctgttggcca ggagtcccag ctgtgccctg cgtctcctct gtggttccag ttgcctcgtt    10800

ctttatcttg gagcagtggc ccccaggggc cttccgtttt agaactattc ctagaggaaa    10860

ctaactctag gaaaattaag ctgtgtttta aggaatacga gttaggttac agaaaggcca    10920

aaaagtgatt gaaatgaggt atcacagatg aaaattctct ataccgcaaa tcaccattta    10980

aatgtattgg cctggtgtag cctctcctat gaagtagata acattaacaa aatgcagtga    11040

atagtttttc aactgttttt ttgcaactta tgaaagctaa aatgacttca aaaagctgaa    11100

gtgtgatttc tctttttttg atgggattta agtcactttt ctcacccacc ctgttgtgtg    11160

agttggtact tactgtgtag gcaagacaga gtaagggact ggcctgagct ggtgacaggc    11220

caatcatgtt gagatgcagt gagtgttttc tttctatgct cagattacca caggcctaga    11280

actgaactct ctcacacttg cttcacctat ggctagttcc catcccagca aagtttgttg    11340

agtaacttgc agtgactact tctgcctttt aaaacctttt ttatttttta ttttctgagg    11400

ccggcactgt gaaaccttcg tcgatgtgtg tccccagatg ccctgcctga atggagggac    11460

ttgtgctgtg gccagtaaca tgcctgatgg tttcatttgc cgttgtcccc cggtaagtgc    11520

cctgttgctc atctaagaag gggcattgtc tcttccatac aatctgtgaa cagaactgag    11580

attaaacctg gttttaccaa tcttcgaaat gggaagattt ctcaatttta gctctttcag    11640

aggaaagtgc ttgggttttt ccatttaaag ctgtttacaa gtgacaaaac aaaacaaaaa    11700

caaataaaag ctgtttagac actcccagaa acagtgagct tcccaatcca tgactgtcag    11760

tcttaagaaa aactaaggga aaaccacaaa aagtggtgga gtgccccctt gaaaataggg    11820

ctgatgtgtg gggcttcttg gccccaggct ggagggtaat ctcactgccc agattgggcc    11880

agagttggtg gaaatgctgc tcttacattc tttagcagga accatttgga agcaagttgt    11940

ctcttaaagt agagggaagc tcaattttag ctatttgcta tacccattct tttatcactg    12000

ccagaggttg aaaccttccc aaaacaagag atccctatgc ctcgggagat accaaaagga    12060

aacctgtcta gtaaccttgg cttgggctga acgggaagta cagaagggag tgagatgtgg    12120

aggttttcta gaaacctcaa acttccaata tgactgtttt cctaccaatg ccatttttat    12180

ttcctcactg atttccacag ggattttccg gggcaaggtg ccagagcagc tgtggacaag    12240

tgaaatgtag gaagggggag cagtgtgtgc acaccgcctc tggaccccgc tgcttctgcc    12300

ccagtccccg ggactgcgag tcaggctgtg ccagtagccc ctgccagcac gggggcagct    12360

gccaccctca gcgccagcct ccttattact cctgccagtg tgccccacca ttctcgggta    12420

gccgctgtga actctacacg gcacccccca gcacccctcc tgccacctgt ctgagccagt    12480

attgtgccga caaagctcgg gatggcgtct gtgatgaggc ctgcaacagc catgcctgcc    12540

agtgggatgg gggtgactgt tctctcacca tggagaaccc ctgggccaac tgctcctccc    12600

cacttccctg ctgggattat atcaacaacc agtgtgatga gctgtgcaac acggtcgagt    12660

gcctgtttga caactttgaa tgccagggga acagcaagac atgcaagtaa gggcttcacg    12720

ttttccagaa ctgaagggga ctgtcactaa cacacttcag tttctcgttc ttgctcctaa    12780

ccactccagt gcttcagcct aagctgcctc tgcttttcag atggtgccag ccttgtccca    12840

tcgcacactg ccctgtgctc tcccttgctg acaatgggcc aggaatgctc attgcataat    12900

gaccctctct ctctgcctat ctttgccttc tcacctgctg ccttcgtgac ctcctggggg    12960

atataacttt tggaagtggt gtttcccact tcaagcagcc tctcacataa cctgcctgca    13020

ggatggatgg aaaggtctgt atctctctct tcaccccatt cctttcccta agactgtttt    13080

tccccatcta gatttatcag gaagcatgaa ttagattaag tctgtgaacc ctcccggtct    13140

taattgtata ggatgctcta tggtttactt aggaactttc ctattaacta gccattccat    13200

ataatttaat cccaattaat tctcagcaac tcacgaggca taggtattac taacattctt    13260

tcataggtga gagaacttag gcccaagggt taaagaactt gccaaagcaa gttgtttctt    13320

tgactcctaa tcttctgatt gagctagcat gaaaagttgt accaaatagt ataaatatca    13380

aggggtaggg gatgaggaga ggagagtata gatggaatag tttgtacatc atttaggttt    13440

gggggttcta attccttttc caaatattga aagagcctgt acaagtaata tctggtgtgc    13500

tataaggaca tacccatctg cctttacctt ctgtagttgg gattcactct tgaaagggaa    13560

agaaatgggt catgttaata ttgttctctg tatggcaact ctcaatggtt cagggccttg    13620

tatcaagttt ctagaggcat ctttcacttc ctaaagcccg ttgttacctt actgggggca    13680

atggatttct ctaaagtaga ggaagcatga accaggttga cttttgtttc agatatgcag    13740

ctttgtttga aaacctgact taacaggctt gtaaactgcc tgggagcccc taagctcctg    13800

cagcatagtg agtacaatgt tcttcattta ggaagtactc aacaaggatg agtggcatag    13860

gcatcaggga taggagatgc aaagaaggtt ttgtggggca tttgggtcct gggtgtgggc    13920

cacagaaaat gggtaggaaa atccacagta gttccaaatg aaaaagcaaa tagagctcca    13980

gtctaatctg agctcttttg cctgttctct gcttcccctt acctaggtat gacaaatact    14040

gtgcagacca cttcaaagac aaccactgtg accaggggtg caacagtgag gagtgtggtt    14100

gggatgggct ggactgtgct gctgaccaac ctgagaacct ggcagaaggt accctggtta    14160

ttgtggtatt gatgccacct gaacaactgc tccaggatgc tcgcagcttc ttgcgggcac    14220

tgggtaccct gctccacacc aacctgcgca ttaagcggga ctcccagggg gaactc        14276


<210> 8
<211> 20
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 8
Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met Lys Lys Gln 
1               5                   10                  15      
Arg Met Thr Arg 
            20  

<210> 9
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 9
Met Val Tyr Pro Tyr 
1               5   

<210> 10
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 10
Met Val Tyr Pro Tyr Tyr 
1               5       

<210> 11
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 11
Met Val Tyr Pro Tyr Tyr Gly 
1               5           

<210> 12
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 12
Met Val Tyr Pro Tyr Tyr Gly Glu 
1               5               

<210> 13
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 13
Met Val Tyr Pro Tyr Tyr Gly Glu Lys 
1               5                   

<210> 14
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 14
Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser 
1               5                   10  

<210> 15
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 15
Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala 
1               5                   10      

<210> 16
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 16
Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala 
1               5                   10          

<210> 17
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 17
Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met 
1               5                   10              

<210> 18
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 18
Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met Lys 
1               5                   10                  

<210> 19
<211> 15
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 19
Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met Lys Lys 
1               5                   10                  15  

<210> 20
<211> 16
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 20
Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met Lys Lys Gln 
1               5                   10                  15      



<210> 21
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 21
Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met Lys Lys Gln 
1               5                   10                  15      
Arg 
    

<210> 22
<211> 18
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 22
Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met Lys Lys Gln 
1               5                   10                  15      
Arg Met 
        

<210> 23
<211> 19
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 23
Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met Lys Lys Gln 
1               5                   10                  15      
Arg Met Thr 
            

<210> 24
<211> 20
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 24
Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro Glu Gly 
1               5                   10                  15      
Phe Thr Leu Arg 
            20  

<210> 25
<211> 5
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 25
Met Ala Lys Arg Lys 
1               5   

<210> 26
<211> 6
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 26
Met Ala Lys Arg Lys Arg 
1               5       

<210> 27
<211> 7
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 27
Met Ala Lys Arg Lys Arg Lys 
1               5           

<210> 28
<211> 8
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 28
Met Ala Lys Arg Lys Arg Lys His 
1               5               

<210> 29
<211> 9
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 29
Met Ala Lys Arg Lys Arg Lys His Gly 
1               5                   

<210> 30
<211> 10
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 30
Met Ala Lys Arg Lys Arg Lys His Gly Ser 
1               5                   10  

<210> 31
<211> 11
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 31
Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu 
1               5                   10      

<210> 32
<211> 12
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 32
Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp 
1               5                   10          

<210> 33
<211> 13
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 33
Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu 
1               5                   10              

<210> 34
<211> 14
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 34
Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro 
1               5                   10                  

<210> 35
<211> 15
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 35
Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro Glu 
1               5                   10                  15  

<210> 36
<211> 16
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 36
Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro Glu Gly 
1               5                   10                  15      



<210> 37
<211> 17
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 37
Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro Glu Gly 
1               5                   10                  15      
Phe 
    

<210> 38
<211> 18
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 38
Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro Glu Gly 
1               5                   10                  15      
Phe Thr 
        

<210> 39
<211> 19
<212> PRT
<213> Homo sapiens

<220> 
<223> NOTCH2 fragment

<400> 39
Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro Glu Gly 
1               5                   10                  15      
Phe Thr Leu 
            

<210> 40
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> EMSA probe

<400> 40
cagccctgtg ggaacttgct g                                              21


<210> 41
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 41
gcccccttga aaatagggct                                                20


<210> 42
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 42
agattgggcc agagttggtg                                                20


<210> 43
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 43
ttccacaggg attttccggg                                                20


<210> 44
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 44
attactcctg ccagtgtgcc                                                20


<210> 45
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 45
tgtgaactct acacggcacc                                                20


<210> 46
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 46
ccaggggaac agcaagacat                                                20


<210> 47
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 47
ccacttcaag cagcctctca                                                20


<210> 48
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 48
accttcgtcg atgtgtgtcc                                                20


<210> 49
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 49
agcttaggct gaagcactgg                                                20


<210> 50
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 50
atgtaggaag ggggagcagt                                                20


<210> 51
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 51
atgtcttgct gttcccctgg                                                20


<210> 52
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 52
gagtcaggct gtgccagtag                                                20


<210> 53
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 53
taataaggag gctggcgctg                                                20


<210> 54
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 54
gcactgtgaa accttcgtcg                                                20


<210> 55
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 55
cacagcacaa gtccctccat                                                20


<210> 56
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 56
tttcagatgg tgccagcctt                                                20


<210> 57
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 57
taagaccggg agggttcaca                                                20


<210> 58
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 58
tgtgaaccct cccggtctta                                                20


<210> 59
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 59
ctcctcatcc cctacccctt                                                20


<210> 60
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 60
gtgctctccc ttgctgacaa                                                20


<210> 61
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 61
ggctgcttga agtgggaaac                                                20


<210> 62
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 62
tgagcaacag ggcacttacc                                                20


<210> 63
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 63
tgcctgaatg gagggacttg                                                20


<210> 64
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 64
cagcccaagc caaggttact                                                20


<210> 65
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 65
accttttgcc agagttgcct                                                20


<210> 66
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 66
ccgccagtgt gttcaagact                                                20


<210> 67
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 67
gtctgtcgtc agtgagtggc                                                20


<210> 68
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 68
tcttgaacac actggcggtt                                                20


<210> 69
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 69
ggatgacacg cagatccctt                                                20


<210> 70
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 70
gtacccctgc ccacttttca                                                20


<210> 71
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 71
gaaaagtggg caggggtaca                                                20


<210> 72
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 72
ctccccttca gcatcaggtc                                                20


<210> 73
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 73
gtcttggctg aaaagtgggc                                                20


<210> 74
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 74
gtgctttcct cccgaaggtt                                                20


<210> 75
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 75
aatccctgac tccagaacgc                                                20


<210> 76
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 76
ttgccatgat tacccccagc                                                20


<210> 77
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 77
agaccactga aaccttcggg                                                20


<210> 78
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 78
cccaccttcc ttagtctggc                                                20


<210> 79
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 79
ctgaaaagtg ggcaggggta                                                20


<210> 80
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 80
cctcccgaag gtttcagtgg                                                20


<210> 81
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 81
gccagactaa ggaaggtggg                                                20


<210> 82
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 82
agtcttgaac acactggcgg                                                20


<210> 83
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 83
gtggggacct gatgctgaag                                                20


<210> 84
<211> 20
<212> DNA
<213> Homo sapiens

<220> 
<223> Polynucleotide probe

<400> 84
ccgtgttctt gaagcagtgg                                                20


<210> 85
<211> 14122
<212> DNA
<213> Homo sapiens

<220> 
<223> NOTCH2 starting downstream of exon 20 and ending upstream of
      START1

<400> 85
gtaagctttg ctcccttggg ctcaggtcat tcactgcagt attgactgtc cagtggcatt       60

tagagaaggt atcatttttt tgtggaataa gagggaaggg cagatagtag tgggtgggca      120

gggctctggg gaaagggctc aagacagaag gtgtaagggt agaggaatag gttcagagat      180

tcggagaaga atgtatttga aatgaaacta aggtatattc cactttcagg gtttattttt      240

aatatgcatc tggtactgag ggttgtgaag aactggctaa gaataagatt ggatgtgtca      300

gccagtttag atttacttgc tcattggttg atttgaaccc catgtgtcac atgttcttct      360

atgacatttc tccctcactg ggtttcccag gtgtgcttgt tgaacacttg tgccagcact      420

caggtgtctg catcaatgct ggcaacacgc attactgtca gtgccccctg ggctatactg      480

ggagctactg tgaggagcaa ctcgatgagt gtgcgtccaa cccctgccag cacggggcaa      540

catgcagtga cttcattggt ggatacagat gcgaggtgag gacactgagc aagcagaggt      600

catggacctc ccaggagatt gtacaactgt ttgagcactg atatattgaa tttagctgct      660

tgtatcttat attgatagtt tatagatttt taccaatccc cgtcataatg tttaccactg      720

tttctttcag cctctctgtg caataagtta acaggtccct agtatgatat ttttataggc      780

gtctggaacc atcccagctc cttaggcttg cttttaggat tcagagccaa gagtcactac      840

cagagtgcat tttacaggcc cacccaacat agcagtccac acttccctga atagcagctg      900

agataggaaa aactgctttg tggagtgtcc ctttggcccc tgtcaccttt gtatttagtc      960

attaatcagt caactagcaa ttttctctca aaaaaaaaaa atgttgctca tcctgttccc     1020

catagcatca tgctaaacgt tacatgtata tatttgagga agtatgtgtc ttcaaggtac     1080

atgtcactat tttaatgtct gggctgataa tggttagagc aagcaagata ttagcaaaat     1140

gcctgagaca ttaatttgat accaattcaa accatcaagc aacactgaga aaagctttgc     1200

ttctctattg ttatataaat gagccaacga tagcttctgt attttggccc ctaggttgtt     1260

tatttcttca cagcaggctg gggctgggtc tcattagctc aaaagcctac cagtgccaaa     1320

cccaaatttt gacacatcta gttgttttaa acatagcccc caaataagca gatttttagc     1380

tatttagagc ttgcctgctt tgcatagcct gtaaaactgc agccaaaatc tgctagccat     1440

agtataagta ggacaagata taccctgggg ccatacagac cccaggctga tgctggcctt     1500

tagagctctc tgacccagag attcctgcca ctggctgttg agtgacatca cctagactcc     1560

ttctctgatc cttctttccc agagtttact tgctgtcttc cccttactca cctacccctc     1620

tggaaggtct catgctattt gggacttctc ccaggtgcaa acctgtcaaa gtgtccaaat     1680

aaagccacct cacagccata tcttttttct tggtcagccc tgaaatcctt ccaaccccta     1740

cagccaccac agccagccag ccagccccac ctccctctac ccctaagcct atctcaacca     1800

gtttctcaca catagatcca atttcctaaa cctggagatc aataattgca tgtctgtact     1860

accatccaca tatgcctttt gaccgagtca tagggtcctc atcacatacg gaggaatgtg     1920

tattttaaag atgaggaaac ctgtacccag gaggaacaaa aggtttgcac acaagtcaaa     1980

tctgaaacat ccttcattgt attcagtcct tgccttccct ttaaagtgcc tttttcaact     2040

gaaagaggag taggtaaatg ccagtaagct gcaggttttc tgtccctgca tagaatgatt     2100

agcagagagt gtgatggttc cagagaaaac atacaaaagc taaattagga ggtgggagac     2160

agtcacagaa atgttccaga tctcactagc tctcatggtc tgtttccagt aatggtccaa     2220

tatttcttgt cctttttgtt tcctcatggc agtgtgtccc aggctatcag ggtgtcaact     2280

gtgagtatga agtggatgag tgccagaatc agccctgcca gaatggaggc acctgtattg     2340

accttgtgaa ccatttcaag tgctcttgcc caccaggcac tcggggtatg aaatcatcct     2400

tatccatttt ccatccaggg cattgtctta agttataaat ccattcttag tgttcagggg     2460

attttataaa attaaagata ggaagactag cttcattcca agcatttagt tctacatcct     2520

agtaattcaa gccattttat tctcccatct cttgctagct ctgatgttgt ggtttatgtt     2580

gtcagtttta tctggttgtt tggcatcttg atattccatg aaacacagaa tatggaaggg     2640

atacaacatt agcataacat taaaaaatta gcctggtcag taagatttct tgttgcttca     2700

cagaaaagca actaatggcc tctaaaataa acaatttaca tttacctgct tttgtatttt     2760

tttaattagc caagtcttac ctctataagg tgggggaatg aatgaaatga aaatatctgc     2820

ctattttcat agcttcaggg gaggatactg atggtgtaag gttctacctt aggatgcagt     2880

aaggcctgat gagagatgca accctggact gttgagtgat ggggccatca ttcttctgtg     2940

ggcattgcca ctgcttttga actgagtggt atggccatca ttctgctgtg gacattgaca     3000

ctgcttttga accatccctt ggaaagagct ttgagtattg tttgttagaa gggatgtagt     3060

tatgctgggg cctactctga gaaggctgtg aaaaaaatgt aaaaggccat ccacactggt     3120

gagaaattca tccttgttag tgtcaaagag aatagaatgc cagagaagta tttgtattgc     3180

cttagagctt tgtgtcagta aagtttgata atttgccacc ccaggtatca gagtttgact     3240

aaattaaaat aggagagtac cctagtagta ggctgattat taaggaatga ggttaatggg     3300

aagaagaaaa ctaaggagaa acagtcttta agtatttgaa gaattgtcct gtaaaaagga     3360

gaattgttct ttattctaga aatcagtggt tgagtagaaa ttaattccag ttcattgtta     3420

gtttgttcct ttgagaaact gtactggtta ggacaagcta cgattctggt gatagctgtt     3480

atcgtagttc atttatgttg ctataaaaga atacctgaga ctaagtaatt tatttttcga     3540

aagaggtata tttggctcgc agttctatag gctgtacagg aagcacggtg ccagcatctg     3600

cctctggtgt gagcgtcagg ctgtttccac tcatggtgaa aagtgaagaa gatccaggga     3660

cccaaacacc tcccattagg ccccacctcc aacattggag atcacatttt aacatgtggt     3720

ttggtgcagt caaacttcaa gctatagcag ctaattaaac ctcaaatctc agagcttaat     3780

ataacactga ttttgtcact caaataaagt cgaatatgtg ttgggctacc tttctctgtg     3840

ttttagatat gtggtttgaa acacctggcc tccaaggcct ccacagtaca gggaagaggg     3900

acagacttga agggtcatac agcagcttcc actagctcag tctggaagca acacatatca     3960

ctatccctcg cagtatattg accggaatta ttaaatggtc tctgtgactt caagggaggc     4020

tgggaaatat aggagagtac atgagtattc atcaaactct aaaatcacta ctataccatg     4080

aacttttaat taataagaca tgtccagtcc tagaatggat catttcagaa ggaaacaaaa     4140

tttttgtctc ttctaaccat atggtaaaga tggcttagaa tactagtttt gatattatca     4200

ttgacagtct ttttctttca gcactttgaa tatatcatcc cactgctttc tgatatccat     4260

ggtttttaat gagaaatatg ctgttaatct tattgaggtt cccttatatg tgatacattg     4320

cttctttctt gatgccttca agattcttta tcttttgata gtttgattat gatgtatgta     4380

ggtatgaatt tctttgagtt tatcctactt acagttcctt ggattatttt actgtgtgtg     4440

cttgtttagg tatgtggaac agtatttttt tatcctgact taacttctct ggccattggt     4500

aaacattcca ggaaactctc aagtcccata accccattgt tagagtcatc acaatgtgtg     4560

ttttggtcac catatttcta agccttagat ctttgcctgc atgtcccacc agtttcccag     4620

gtcaagggct aaatgtaaca gttctgcctc ttcctactac tttgcttcag gctgaggttg     4680

agttctctct cagttgatag atctgtttat ttctggtggt tccattctga tggggaaata     4740

tgcatttatg ctcattttac tagcaatccc taaatatcaa atattctttg agacagggag     4800

catatactag attttgtttg tttttacttt tttgttttca atttactcta tgtataaggt     4860

gatatatgca tatatgcata tagaccaaaa gtgtattcac acatagaaaa gtatacagtg     4920

aaaatacttc tcattcccat ctctcttctg gtgggcaaat tttccctctc ctgcaaacat     4980

gtaatcgcca cttttggttg tttgtgtttc tttctagaat ttttcaaaaa ctgtatcctt     5040

cagaatttct ttatgtagag agaagccaaa tgcaaagata ttttatttcc tttacttttt     5100

actctgaaga tagaatatta gacacatttt ttgcacttga ttttttttta cttaattgga     5160

gatattttca tatcaaaata tagaacttcc tctctctctc tctgagatag atagatagat     5220

agatagatag atagatagat agatagatat ttgtttgttt gtttgttttg agatggagtt     5280

ttgctcttgt tgcccaggct ggagtgcaat ggtatgatct cagctcaccg caacctccgc     5340

ctcctgggtt cgagtgattt tcctgcctca gcgccctgag tagctgggat tacaggcatg     5400

tgccaccatg cctggctgat tttgtatttt taatagagac agggtttctc catgttggtc     5460

aggctggtct tgaactcctg gcctcaagca atccacccgc ctcagcctcc caaagtgctg     5520

ggatgacagg cgtgagccac cacacccagc ctgaacttcc tcaatatttt ttatagctac     5580

agaattccct tttacaggca taccatattt taaccagtgc catcatgata gatatttcag     5640

ttatcttgca ggcatataag tatattggtg aaataaattt tcagaaatag aatcgctgga     5700

ttggataata tgtgcattta tcattttaat cagtgattgc agtatatcag catattggct     5760

ttttcttaag gtggagaata tattttcatt taagaatcat tttcttttga ttttttttgc     5820

agtttctttg tttatatata tatatatgta tatatacata tatatatata tacacacata     5880

tatctttttt cccacattaa gttgttgatg taatgttttg tggaaattgg ctatgatata     5940

aaaaaacaaa tatattccca gtattttttt atcttttttc tttatagtga tttttagtgc     6000

acacttttac tttttaatca agttgaattt atcactttta aaatggcttc tggattttga     6060

gttgtagtta gcaacatcat atacacttga agatcgtaaa gaaattctcc catattttct     6120

tcaagtactt ttgccatatg actactcatt tgttaataca caatttattg aatattttgt     6180

tttttatata tataatgatt tgagatggca cctttgccag attctaaatt cccatgtgta     6240

tttttggtgt tcttctggat tttctttatt ttctgtgtta ttctattaat tcaccaataa     6300

cgttctattt caattattaa ggatcttctt cttcatagtt ttcctggtta ttttttttca     6360

cataatttta taatcagctt gtctgttaat aaattcctgt tgataatttt tagtggggtc     6420

tcattaaatt tatgaattat agtatagaga aaactgataa ctttatgatg aggagtcttg     6480

ctaaccaaat cctggtatgt ctttccattt attcaagtct cttttgtgtc tgttaggaca     6540

gtattaaagt tgtcttcatt taggtgtaac acatttcttg tgaagattgt tcctaggtat     6600

tttatctttg gtaatttggt aattgctttt gaaaattggg ccttacttta catttaaaaa     6660

aaaaaatctt gcttttgtta gtgtatgcta caatgcaagt ggcaggaata catacagaac     6720

tgttttcttt tgtacctttt tttttttttt ttttaagaca gagtcttgct ctgttgccca     6780

ggctggagtg cagtagcgca atctcggctt actgcaagct ccacctccca ggttcatgcc     6840

attctcctgc ctcagcctcc cgagtagctg ggactacaag cgcccgccac catgcctggc     6900

taattttttt tttgtatttt ttagtggaga cggggtttca ccatgttagc caggatggtc     6960

tcgatctcct gacctcgtga tccacctgcc ttggcctccc agagtgctgg gattacaggc     7020

ttgagccact gcacccagcc tgtacctttt tttttaatta tgattattat tattttttga     7080

gacagagtct tgctctgttg cccaggctgg agtgcagtgg cataacctcg gctcactgca     7140

agcttcatct cccggtttca agtgattctc ctgcctcagc ctcccaagta gctgagatta     7200

cagacatgta ccaccacacg cagctaattt ttgtatattt agtagagatg gggtttcact     7260

gtgttgggca gattggtctt gaactcctga cctcaagtga tccgcctgcc ttagcctccc     7320

aaagtgctgg gattacaggt gtgagccact gtgcccagcc tcttttgtgc ctttttgaat     7380

taatcataga ataatttcta gaatagtcat tgatttcttt tgtttctttg taagacacta     7440

tatgcagata ttcatactag atggctcatt tacatctata gtacaataaa ttagtcctgt     7500

tttaaatgga ataacttttg aactctcagc aggaaattta tcctctattt ttgttaaata     7560

aaaagcattg gtgcacttat acactattac agaaaaaagc cagtgattat aaaacttaaa     7620

aatgtatttc attcaaaatt cagttccagt tgttaccaat atttttacat aacctatgta     7680

tagtcatggg tcacttaaca gtggggatat gttctgagaa atatgccctt aggcaatttc     7740

attgttgtac aatcatcatg gagtgtaatt acacaaacag agagagtatg gcttactaca     7800

cacctaggct ccaaacctgc accttgtttt actgaactga atattgtagg caattataac     7860

acaatggtaa gtatttatgt gtctgaacat atttaagaag aggtacagta gaagatttaa     7920

aaggtacagt aaaaatacaa tataaaagat aaaaaatagt acacctgtat agggcattta     7980

ctatgaaagg agcttgcaag actggaactt gctgggtgag tcagtgaatg gtaagtgaat     8040

gtgaaggcct aggacattac tgtacactac tgcagacttt gtaaatactg tacacctaag     8100

ctacactgaa tttatttaaa aagtaattgt gctatgacat tacaaggcta tgatgttact     8160

aggcaacagg aatttgtcag cttcagcttc attatgggac cactgtcgta tgtgctgcct     8220

gcattgacta aaatgtcatt atgcggttgc ataactgtat ttattgttat gttctttttt     8280

ggactgtttt tatattttgg attatacttt ggaaaaatta ctgagcctct cttgagctcc     8340

agtttccttc tctttgagat gggacaaata ataggaccta caccataggg tgctacttca     8400

ctggattgtg tgggagagta catgcggagc cctagtatgt tctttccttt acttgtacaa     8460

ctcaccagga tgacagctgt catgaataaa gagtgtgctt tgccctgccc aactacaagg     8520

tcccactacc agttgaggag tatactctga ttcattgtga aaatgccaac aagggtggtt     8580

atcccttgct ggaaagcagg ttaaaaggat tttcataatt ctgtacctct tctctttcct     8640

ccaggcctac tctgtgaaga gaacattgat gactgtgccc ggggtcccca ttgccttaat     8700

ggtggtcagt gcatggatag gattggaggc tacagttgtc gctgcttgcc tggctttgct     8760

ggggagcgtt gtgagggaga catcaacgag tgcctctcca acccctgcag ctctgagggc     8820

agcctggact gtatacagct caccaatgac tacctgtgtg tttgccgtag tgcctttact     8880

ggtgagaagc tctctagcct cctggccact ctgccttgga ggatggtttt agtgaacaaa     8940

ttgggccctg tgagttgtcc cagacccaag tgaagctttt cttatataag aaaaacaaca     9000

gcagcttaat tttttaaagc cagttttttc ttagtctgta ctttatggat gttatgatca     9060

gtgtctacct ttaatttttc ctaagagatt cttttgttgt gcattgatta tatcatgcta     9120

tggcaggaat attttttaca atgtatattg aaagtagttg aacaaaataa cattttttaa     9180

tagtggcaaa atatccaaaa cctaaaattt actatctgaa tcattttaaa gtgtacagtg     9240

tacagttcag tggcattgtt tagtacattg acattgttgt tctactatca cccccattca     9300

ttcacagaac tcttttcatc tgaacaaaat aacattttgt tttaaggaac cttacgtcta     9360

actccggttt cttcaccctg cctcctttga catgtgatgg cttgaattac tgggtagttc     9420

ctgccaccat gatctttcca cccctaggac tcagagaagc ttaggaccct gcttagatac     9480

ttaaaggggg caggtccaaa ttcaagtgtg tttaaccaaa gatcagttga tgtgggtatg     9540

aaatgaaaag ttgcagtggt cacaagtaat gccttgccca gtaaaggctt ggccatgttc     9600

ctactctgtt cccaagcttc tttctttcat cacagggcct gaagatgacc aagctctgcc     9660

tcagaatagg ggtcttatca caagaactta ctagttactt ctggagaggg cagcatggtg     9720

acttttggga actaaaatag ttgtttgtat ccagatgtgg caggatactc agatttgaaa     9780

tttatcatgc atttcctggg gtctgtagtt gtatttctta tatggagggt gtgatcagat     9840

tccttaggag tcagaaaata ggctttaata gtctgtttac aaacaattca tcaagctgaa     9900

ctctgctaca tcctgagccc atctccagcc atctttcctt ccaactttaa agatatgcta     9960

ccttacaatc ttggaatttt gtaaagaatg ggagggattc tgcaatatgg aagctccctg    10020

gatacactaa catcaaaaaa gaaatagtcc attgtgaaca taatagctat tgaggcaatg    10080

tggaacagaa taagtatgaa taatctgtct acagcctcgt attggccaaa ctgcactttg    10140

aaagccaaag catcaaaact ggctcctgtt tctttcattg cccctgaggc ttttttctct    10200

ggaaacacaa gcatttgcaa agtaaggggg aagcaggaga aggaaggaat ggagaccact    10260

ttgaagtagt atcccacagc caggaagtag tgtttgtgca ttttccacat ttgtgaatga    10320

aaaaaaaaaa atcccttgaa tacattgagc acagttattg tgggatgctg ttgcagagat    10380

aaacagcaag ggactggtgg tccaccaagc tgtgtccatg tggtggctgc tcttggttag    10440

cggctgctgc tgtgatttga agagacaaac atttatacct cttgctgctt gatctcgttg    10500

gccaaaaaca ttactatttt tatttcattt ttaaagctac ctcttctttc ccaagtgacc    10560

accggccaaa tggggcctat ctcctgctgt tggccaggag tcccagctgt gccctgcgtc    10620

tcctctgtgg ttccagttgc ctcgttcttt atcttggagc agtggccccc aggggccttc    10680

cgttttagaa ctattcctag aggaaactaa ctctaggaaa attaagctgt gttttaagga    10740

atacgagtta ggttacagaa aggccaaaaa gtgattgaaa tgaggtatca cagatgaaaa    10800

ttctctatac cgcaaatcac catttaaatg tattggcctg gtgtagcctc tcctatgaag    10860

tagataacat taacaaaatg cagtgaatag tttttcaact gtttttttgc aacttatgaa    10920

agctaaaatg acttcaaaaa gctgaagtgt gatttctctt tttttgatgg gatttaagtc    10980

acttttctca cccaccctgt tgtgtgagtt ggtacttact gtgtaggcaa gacagagtaa    11040

gggactggcc tgagctggtg acaggccaat catgttgaga tgcagtgagt gttttctttc    11100

tatgctcaga ttaccacagg cctagaactg aactctctca cacttgcttc acctatggct    11160

agttcccatc ccagcaaagt ttgttgagta acttgcagtg actacttctg ccttttaaaa    11220

ccttttttat tttttatttt ctgaggccgg cactgtgaaa ccttcgtcga tgtgtgtccc    11280

cagatgccct gcctgaatgg agggacttgt gctgtggcca gtaacatgcc tgatggtttc    11340

atttgccgtt gtcccccggt aagtgccctg ttgctcatct aagaaggggc attgtctctt    11400

ccatacaatc tgtgaacaga actgagatta aacctggttt taccaatctt cgaaatggga    11460

agatttctca attttagctc tttcagagga aagtgcttgg gtttttccat ttaaagctgt    11520

ttacaagtga caaaacaaaa caaaaacaaa taaaagctgt ttagacactc ccagaaacag    11580

tgagcttccc aatccatgac tgtcagtctt aagaaaaact aagggaaaac cacaaaaagt    11640

ggtggagtgc ccccttgaaa atagggctga tgtgtggggc ttcttggccc caggctggag    11700

ggtaatctca ctgcccagat tgggccagag ttggtggaaa tgctgctctt acattcttta    11760

gcaggaacca tttggaagca agttgtctct taaagtagag ggaagctcaa ttttagctat    11820

ttgctatacc cattctttta tcactgccag aggttgaaac cttcccaaaa caagagatcc    11880

ctatgcctcg ggagatacca aaaggaaacc tgtctagtaa ccttggcttg ggctgaacgg    11940

gaagtacaga agggagtgag atgtggaggt tttctagaaa cctcaaactt ccaatatgac    12000

tgttttccta ccaatgccat ttttatttcc tcactgattt ccacagggat tttccggggc    12060

aaggtgccag agcagctgtg gacaagtgaa atgtaggaag ggggagcagt gtgtgcacac    12120

cgcctctgga ccccgctgct tctgccccag tccccgggac tgcgagtcag gctgtgccag    12180

tagcccctgc cagcacgggg gcagctgcca ccctcagcgc cagcctcctt attactcctg    12240

ccagtgtgcc ccaccattct cgggtagccg ctgtgaactc tacacggcac cccccagcac    12300

ccctcctgcc acctgtctga gccagtattg tgccgacaaa gctcgggatg gcgtctgtga    12360

tgaggcctgc aacagccatg cctgccagtg ggatgggggt gactgttctc tcaccatgga    12420

gaacccctgg gccaactgct cctccccact tccctgctgg gattatatca acaaccagtg    12480

tgatgagctg tgcaacacgg tcgagtgcct gtttgacaac tttgaatgcc aggggaacag    12540

caagacatgc aagtaagggc ttcacgtttt ccagaactga aggggactgt cactaacaca    12600

cttcagtttc tcgttcttgc tcctaaccac tccagtgctt cagcctaagc tgcctctgct    12660

tttcagatgg tgccagcctt gtcccatcgc acactgccct gtgctctccc ttgctgacaa    12720

tgggccagga atgctcattg cataatgacc ctctctctct gcctatcttt gccttctcac    12780

ctgctgcctt cgtgacctcc tgggggatat aacttttgga agtggtgttt cccacttcaa    12840

gcagcctctc acataacctg cctgcaggat ggatggaaag gtctgtatct ctctcttcac    12900

cccattcctt tccctaagac tgtttttccc catctagatt tatcaggaag catgaattag    12960

attaagtctg tgaaccctcc cggtcttaat tgtataggat gctctatggt ttacttagga    13020

actttcctat taactagcca ttccatataa tttaatccca attaattctc agcaactcac    13080

gaggcatagg tattactaac attctttcat aggtgagaga acttaggccc aagggttaaa    13140

gaacttgcca aagcaagttg tttctttgac tcctaatctt ctgattgagc tagcatgaaa    13200

agttgtacca aatagtataa atatcaaggg gtaggggatg aggagaggag agtatagatg    13260

gaatagtttg tacatcattt aggtttgggg gttctaattc cttttccaaa tattgaaaga    13320

gcctgtacaa gtaatatctg gtgtgctata aggacatacc catctgcctt taccttctgt    13380

agttgggatt cactcttgaa agggaaagaa atgggtcatg ttaatattgt tctctgtatg    13440

gcaactctca atggttcagg gccttgtatc aagtttctag aggcatcttt cacttcctaa    13500

agcccgttgt taccttactg ggggcaatgg atttctctaa agtagaggaa gcatgaacca    13560

ggttgacttt tgtttcagat atgcagcttt gtttgaaaac ctgacttaac aggcttgtaa    13620

actgcctggg agcccctaag ctcctgcagc atagtgagta caatgttctt catttaggaa    13680

gtactcaaca aggatgagtg gcataggcat cagggatagg agatgcaaag aaggttttgt    13740

ggggcatttg ggtcctgggt gtgggccaca gaaaatgggt aggaaaatcc acagtagttc    13800

caaatgaaaa agcaaataga gctccagtct aatctgagct cttttgcctg ttctctgctt    13860

ccccttacct aggtatgaca aatactgtgc agaccacttc aaagacaacc actgtgacca    13920

ggggtgcaac agtgaggagt gtggttggga tgggctggac tgtgctgctg accaacctga    13980

gaacctggca gaaggtaccc tggttattgt ggtattgatg ccacctgaac aactgctcca    14040

ggatgctcgc agcttcttgc gggcactggg taccctgctc cacaccaacc tgcgcattaa    14100

gcgggactcc cagggggaac tc                                             14122


<210> 86
<211> 2471
<212> PRT
<213> Homo sapiens

<220> 
<223> Wild-type NOTCH2 (with signal peptide)

<400> 86
Met Pro Ala Leu Arg Pro Ala Leu Leu Trp Ala Leu Leu Ala Leu Trp 
1               5                   10                  15      
Leu Cys Cys Ala Ala Pro Ala His Ala Leu Gln Cys Arg Asp Gly Tyr 
            20                  25                  30          
Glu Pro Cys Val Asn Glu Gly Met Cys Val Thr Tyr His Asn Gly Thr 
        35                  40                  45              
Gly Tyr Cys Lys Cys Pro Glu Gly Phe Leu Gly Glu Tyr Cys Gln His 
    50                  55                  60                  
Arg Asp Pro Cys Glu Lys Asn Arg Cys Gln Asn Gly Gly Thr Cys Val 
65                  70                  75                  80  
Ala Gln Ala Met Leu Gly Lys Ala Thr Cys Arg Cys Ala Ser Gly Phe 
                85                  90                  95      
Thr Gly Glu Asp Cys Gln Tyr Ser Thr Ser His Pro Cys Phe Val Ser 
            100                 105                 110         
Arg Pro Cys Leu Asn Gly Gly Thr Cys His Met Leu Ser Arg Asp Thr 
        115                 120                 125             
Tyr Glu Cys Thr Cys Gln Val Gly Phe Thr Gly Lys Glu Cys Gln Trp 
    130                 135                 140                 
Thr Asp Ala Cys Leu Ser His Pro Cys Ala Asn Gly Ser Thr Cys Thr 
145                 150                 155                 160 
Thr Val Ala Asn Gln Phe Ser Cys Lys Cys Leu Thr Gly Phe Thr Gly 
                165                 170                 175     
Gln Lys Cys Glu Thr Asp Val Asn Glu Cys Asp Ile Pro Gly His Cys 
            180                 185                 190         
Gln His Gly Gly Thr Cys Leu Asn Leu Pro Gly Ser Tyr Gln Cys Gln 
        195                 200                 205             
Cys Pro Gln Gly Phe Thr Gly Gln Tyr Cys Asp Ser Leu Tyr Val Pro 
    210                 215                 220                 
Cys Ala Pro Ser Pro Cys Val Asn Gly Gly Thr Cys Arg Gln Thr Gly 
225                 230                 235                 240 
Asp Phe Thr Phe Glu Cys Asn Cys Leu Pro Gly Phe Glu Gly Ser Thr 
                245                 250                 255     
Cys Glu Arg Asn Ile Asp Asp Cys Pro Asn His Arg Cys Gln Asn Gly 
            260                 265                 270         
Gly Val Cys Val Asp Gly Val Asn Thr Tyr Asn Cys Arg Cys Pro Pro 
        275                 280                 285             
Gln Trp Thr Gly Gln Phe Cys Thr Glu Asp Val Asp Glu Cys Leu Leu 
    290                 295                 300                 
Gln Pro Asn Ala Cys Gln Asn Gly Gly Thr Cys Ala Asn Arg Asn Gly 
305                 310                 315                 320 
Gly Tyr Gly Cys Val Cys Val Asn Gly Trp Ser Gly Asp Asp Cys Ser 
                325                 330                 335     
Glu Asn Ile Asp Asp Cys Ala Phe Ala Ser Cys Thr Pro Gly Ser Thr 
            340                 345                 350         
Cys Ile Asp Arg Val Ala Ser Phe Ser Cys Met Cys Pro Glu Gly Lys 
        355                 360                 365             
Ala Gly Leu Leu Cys His Leu Asp Asp Ala Cys Ile Ser Asn Pro Cys 
    370                 375                 380                 
His Lys Gly Ala Leu Cys Asp Thr Asn Pro Leu Asn Gly Gln Tyr Ile 
385                 390                 395                 400 
Cys Thr Cys Pro Gln Gly Tyr Lys Gly Ala Asp Cys Thr Glu Asp Val 
                405                 410                 415     
Asp Glu Cys Ala Met Ala Asn Ser Asn Pro Cys Glu His Ala Gly Lys 
            420                 425                 430         
Cys Val Asn Thr Asp Gly Ala Phe His Cys Glu Cys Leu Lys Gly Tyr 
        435                 440                 445             
Ala Gly Pro Arg Cys Glu Met Asp Ile Asn Glu Cys His Ser Asp Pro 
    450                 455                 460                 
Cys Gln Asn Asp Ala Thr Cys Leu Asp Lys Ile Gly Gly Phe Thr Cys 
465                 470                 475                 480 
Leu Cys Met Pro Gly Phe Lys Gly Val His Cys Glu Leu Glu Ile Asn 
                485                 490                 495     
Glu Cys Gln Ser Asn Pro Cys Val Asn Asn Gly Gln Cys Val Asp Lys 
            500                 505                 510         
Val Asn Arg Phe Gln Cys Leu Cys Pro Pro Gly Phe Thr Gly Pro Val 
        515                 520                 525             
Cys Gln Ile Asp Ile Asp Asp Cys Ser Ser Thr Pro Cys Leu Asn Gly 
    530                 535                 540                 
Ala Lys Cys Ile Asp His Pro Asn Gly Tyr Glu Cys Gln Cys Ala Thr 
545                 550                 555                 560 
Gly Phe Thr Gly Val Leu Cys Glu Glu Asn Ile Asp Asn Cys Asp Pro 
                565                 570                 575     
Asp Pro Cys His His Gly Gln Cys Gln Asp Gly Ile Asp Ser Tyr Thr 
            580                 585                 590         
Cys Ile Cys Asn Pro Gly Tyr Met Gly Ala Ile Cys Ser Asp Gln Ile 
        595                 600                 605             
Asp Glu Cys Tyr Ser Ser Pro Cys Leu Asn Asp Gly Arg Cys Ile Asp 
    610                 615                 620                 
Leu Val Asn Gly Tyr Gln Cys Asn Cys Gln Pro Gly Thr Ser Gly Val 
625                 630                 635                 640 
Asn Cys Glu Ile Asn Phe Asp Asp Cys Ala Ser Asn Pro Cys Ile His 
                645                 650                 655     
Gly Ile Cys Met Asp Gly Ile Asn Arg Tyr Ser Cys Val Cys Ser Pro 
            660                 665                 670         
Gly Phe Thr Gly Gln Arg Cys Asn Ile Asp Ile Asp Glu Cys Ala Ser 
        675                 680                 685             
Asn Pro Cys Arg Lys Gly Ala Thr Cys Ile Asn Gly Val Asn Gly Phe 
    690                 695                 700                 
Arg Cys Ile Cys Pro Glu Gly Pro His His Pro Ser Cys Tyr Ser Gln 
705                 710                 715                 720 
Val Asn Glu Cys Leu Ser Asn Pro Cys Ile His Gly Asn Cys Thr Gly 
                725                 730                 735     
Gly Leu Ser Gly Tyr Lys Cys Leu Cys Asp Ala Gly Trp Val Gly Ile 
            740                 745                 750         
Asn Cys Glu Val Asp Lys Asn Glu Cys Leu Ser Asn Pro Cys Gln Asn 
        755                 760                 765             
Gly Gly Thr Cys Asp Asn Leu Val Asn Gly Tyr Arg Cys Thr Cys Lys 
    770                 775                 780                 
Lys Gly Phe Lys Gly Tyr Asn Cys Gln Val Asn Ile Asp Glu Cys Ala 
785                 790                 795                 800 
Ser Asn Pro Cys Leu Asn Gln Gly Thr Cys Phe Asp Asp Ile Ser Gly 
                805                 810                 815     
Tyr Thr Cys His Cys Val Leu Pro Tyr Thr Gly Lys Asn Cys Gln Thr 
            820                 825                 830         
Val Leu Ala Pro Cys Ser Pro Asn Pro Cys Glu Asn Ala Ala Val Cys 
        835                 840                 845             
Lys Glu Ser Pro Asn Phe Glu Ser Tyr Thr Cys Leu Cys Ala Pro Gly 
    850                 855                 860                 
Trp Gln Gly Gln Arg Cys Thr Ile Asp Ile Asp Glu Cys Ile Ser Lys 
865                 870                 875                 880 
Pro Cys Met Asn His Gly Leu Cys His Asn Thr Gln Gly Ser Tyr Met 
                885                 890                 895     
Cys Glu Cys Pro Pro Gly Phe Ser Gly Met Asp Cys Glu Glu Asp Ile 
            900                 905                 910         
Asp Asp Cys Leu Ala Asn Pro Cys Gln Asn Gly Gly Ser Cys Met Asp 
        915                 920                 925             
Gly Val Asn Thr Phe Ser Cys Leu Cys Leu Pro Gly Phe Thr Gly Asp 
    930                 935                 940                 
Lys Cys Gln Thr Asp Met Asn Glu Cys Leu Ser Glu Pro Cys Lys Asn 
945                 950                 955                 960 
Gly Gly Thr Cys Ser Asp Tyr Val Asn Ser Tyr Thr Cys Lys Cys Gln 
                965                 970                 975     
Ala Gly Phe Asp Gly Val His Cys Glu Asn Asn Ile Asn Glu Cys Thr 
            980                 985                 990         
Glu Ser Ser Cys Phe Asn Gly Gly Thr Cys Val Asp Gly Ile Asn Ser 
        995                 1000                1005            
Phe Ser Cys Leu Cys Pro Val Gly Phe Thr Gly Ser Phe Cys Leu His 
    1010                1015                1020                
Glu Ile Asn Glu Cys Ser Ser His Pro Cys Leu Asn Glu Gly Thr Cys 
1025                1030                1035                1040
Val Asp Gly Leu Gly Thr Tyr Arg Cys Ser Cys Pro Leu Gly Tyr Thr 
                1045                1050                1055    
Gly Lys Asn Cys Gln Thr Leu Val Asn Leu Cys Ser Arg Ser Pro Cys 
            1060                1065                1070        
Lys Asn Lys Gly Thr Cys Val Gln Lys Lys Ala Glu Ser Gln Cys Leu 
        1075                1080                1085            
Cys Pro Ser Gly Trp Ala Gly Ala Tyr Cys Asp Val Pro Asn Val Ser 
    1090                1095                1100                
Cys Asp Ile Ala Ala Ser Arg Arg Gly Val Leu Val Glu His Leu Cys 
1105                1110                1115                1120
Gln His Ser Gly Val Cys Ile Asn Ala Gly Asn Thr His Tyr Cys Gln 
                1125                1130                1135    
Cys Pro Leu Gly Tyr Thr Gly Ser Tyr Cys Glu Glu Gln Leu Asp Glu 
            1140                1145                1150        
Cys Ala Ser Asn Pro Cys Gln His Gly Ala Thr Cys Ser Asp Phe Ile 
        1155                1160                1165            
Gly Gly Tyr Arg Cys Glu Cys Val Pro Gly Tyr Gln Gly Val Asn Cys 
    1170                1175                1180                
Glu Tyr Glu Val Asp Glu Cys Gln Asn Gln Pro Cys Gln Asn Gly Gly 
1185                1190                1195                1200
Thr Cys Ile Asp Leu Val Asn His Phe Lys Cys Ser Cys Pro Pro Gly 
                1205                1210                1215    
Thr Arg Gly Leu Leu Cys Glu Glu Asn Ile Asp Asp Cys Ala Arg Gly 
            1220                1225                1230        
Pro His Cys Leu Asn Gly Gly Gln Cys Met Asp Arg Ile Gly Gly Tyr 
        1235                1240                1245            
Ser Cys Arg Cys Leu Pro Gly Phe Ala Gly Glu Arg Cys Glu Gly Asp 
    1250                1255                1260                
Ile Asn Glu Cys Leu Ser Asn Pro Cys Ser Ser Glu Gly Ser Leu Asp 
1265                1270                1275                1280
Cys Ile Gln Leu Thr Asn Asp Tyr Leu Cys Val Cys Arg Ser Ala Phe 
                1285                1290                1295    
Thr Gly Arg His Cys Glu Thr Phe Val Asp Val Cys Pro Gln Met Pro 
            1300                1305                1310        
Cys Leu Asn Gly Gly Thr Cys Ala Val Ala Ser Asn Met Pro Asp Gly 
        1315                1320                1325            
Phe Ile Cys Arg Cys Pro Pro Gly Phe Ser Gly Ala Arg Cys Gln Ser 
    1330                1335                1340                
Ser Cys Gly Gln Val Lys Cys Arg Lys Gly Glu Gln Cys Val His Thr 
1345                1350                1355                1360
Ala Ser Gly Pro Arg Cys Phe Cys Pro Ser Pro Arg Asp Cys Glu Ser 
                1365                1370                1375    
Gly Cys Ala Ser Ser Pro Cys Gln His Gly Gly Ser Cys His Pro Gln 
            1380                1385                1390        
Arg Gln Pro Pro Tyr Tyr Ser Cys Gln Cys Ala Pro Pro Phe Ser Gly 
        1395                1400                1405            
Ser Arg Cys Glu Leu Tyr Thr Ala Pro Pro Ser Thr Pro Pro Ala Thr 
    1410                1415                1420                
Cys Leu Ser Gln Tyr Cys Ala Asp Lys Ala Arg Asp Gly Val Cys Asp 
1425                1430                1435                1440
Glu Ala Cys Asn Ser His Ala Cys Gln Trp Asp Gly Gly Asp Cys Ser 
                1445                1450                1455    
Leu Thr Met Glu Asn Pro Trp Ala Asn Cys Ser Ser Pro Leu Pro Cys 
            1460                1465                1470        
Trp Asp Tyr Ile Asn Asn Gln Cys Asp Glu Leu Cys Asn Thr Val Glu 
        1475                1480                1485            
Cys Leu Phe Asp Asn Phe Glu Cys Gln Gly Asn Ser Lys Thr Cys Lys 
    1490                1495                1500                
Tyr Asp Lys Tyr Cys Ala Asp His Phe Lys Asp Asn His Cys Asp Gln 
1505                1510                1515                1520
Gly Cys Asn Ser Glu Glu Cys Gly Trp Asp Gly Leu Asp Cys Ala Ala 
                1525                1530                1535    
Asp Gln Pro Glu Asn Leu Ala Glu Gly Thr Leu Val Ile Val Val Leu 
            1540                1545                1550        
Met Pro Pro Glu Gln Leu Leu Gln Asp Ala Arg Ser Phe Leu Arg Ala 
        1555                1560                1565            
Leu Gly Thr Leu Leu His Thr Asn Leu Arg Ile Lys Arg Asp Ser Gln 
    1570                1575                1580                
Gly Glu Leu Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met 
1585                1590                1595                1600
Lys Lys Gln Arg Met Thr Arg Arg Ser Leu Pro Gly Glu Gln Glu Gln 
                1605                1610                1615    
Glu Val Ala Gly Ser Lys Val Phe Leu Glu Ile Asp Asn Arg Gln Cys 
            1620                1625                1630        
Val Gln Asp Ser Asp His Cys Phe Lys Asn Thr Asp Ala Ala Ala Ala 
        1635                1640                1645            
Leu Leu Ala Ser His Ala Ile Gln Gly Thr Leu Ser Tyr Pro Leu Val 
    1650                1655                1660                
Ser Val Val Ser Glu Ser Leu Thr Pro Glu Arg Thr Gln Leu Leu Tyr 
1665                1670                1675                1680
Leu Leu Ala Val Ala Val Val Ile Ile Leu Phe Ile Ile Leu Leu Gly 
                1685                1690                1695    
Val Ile Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro 
            1700                1705                1710        
Glu Gly Phe Thr Leu Arg Arg Asp Ala Ser Asn His Lys Arg Arg Glu 
        1715                1720                1725            
Pro Val Gly Gln Asp Ala Val Gly Leu Lys Asn Leu Ser Val Gln Val 
    1730                1735                1740                
Ser Glu Ala Asn Leu Ile Gly Thr Gly Thr Ser Glu His Trp Val Asp 
1745                1750                1755                1760
Asp Glu Gly Pro Gln Pro Lys Lys Val Lys Ala Glu Asp Glu Ala Leu 
                1765                1770                1775    
Leu Ser Glu Glu Asp Asp Pro Ile Asp Arg Arg Pro Trp Thr Gln Gln 
            1780                1785                1790        
His Leu Glu Ala Ala Asp Ile Arg Arg Thr Pro Ser Leu Ala Leu Thr 
        1795                1800                1805            
Pro Pro Gln Ala Glu Gln Glu Val Asp Val Leu Asp Val Asn Val Arg 
    1810                1815                1820                
Gly Pro Asp Gly Cys Thr Pro Leu Met Leu Ala Ser Leu Arg Gly Gly 
1825                1830                1835                1840
Ser Ser Asp Leu Ser Asp Glu Asp Glu Asp Ala Glu Asp Ser Ser Ala 
                1845                1850                1855    
Asn Ile Ile Thr Asp Leu Val Tyr Gln Gly Ala Ser Leu Gln Ala Gln 
            1860                1865                1870        
Thr Asp Arg Thr Gly Glu Met Ala Leu His Leu Ala Ala Arg Tyr Ser 
        1875                1880                1885            
Arg Ala Asp Ala Ala Lys Arg Leu Leu Asp Ala Gly Ala Asp Ala Asn 
    1890                1895                1900                
Ala Gln Asp Asn Met Gly Arg Cys Pro Leu His Ala Ala Val Ala Ala 
1905                1910                1915                1920
Asp Ala Gln Gly Val Phe Gln Ile Leu Ile Arg Asn Arg Val Thr Asp 
                1925                1930                1935    
Leu Asp Ala Arg Met Asn Asp Gly Thr Thr Pro Leu Ile Leu Ala Ala 
            1940                1945                1950        
Arg Leu Ala Val Glu Gly Met Val Ala Glu Leu Ile Asn Cys Gln Ala 
        1955                1960                1965            
Asp Val Asn Ala Val Asp Asp His Gly Lys Ser Ala Leu His Trp Ala 
    1970                1975                1980                
Ala Ala Val Asn Asn Val Glu Ala Thr Leu Leu Leu Leu Lys Asn Gly 
1985                1990                1995                2000
Ala Asn Arg Asp Met Gln Asp Asn Lys Glu Glu Thr Pro Leu Phe Leu 
                2005                2010                2015    
Ala Ala Arg Glu Gly Ser Tyr Glu Ala Ala Lys Ile Leu Leu Asp His 
            2020                2025                2030        
Phe Ala Asn Arg Asp Ile Thr Asp His Met Asp Arg Leu Pro Arg Asp 
        2035                2040                2045            
Val Ala Arg Asp Arg Met His His Asp Ile Val Arg Leu Leu Asp Glu 
    2050                2055                2060                
Tyr Asn Val Thr Pro Ser Pro Pro Gly Thr Val Leu Thr Ser Ala Leu 
2065                2070                2075                2080
Ser Pro Val Ile Cys Gly Pro Asn Arg Ser Phe Leu Ser Leu Lys His 
                2085                2090                2095    
Thr Pro Met Gly Lys Lys Ser Arg Arg Pro Ser Ala Lys Ser Thr Met 
            2100                2105                2110        
Pro Thr Ser Leu Pro Asn Leu Ala Lys Glu Ala Lys Asp Ala Lys Gly 
        2115                2120                2125            
Ser Arg Arg Lys Lys Ser Leu Ser Glu Lys Val Gln Leu Ser Glu Ser 
    2130                2135                2140                
Ser Val Thr Leu Ser Pro Val Asp Ser Leu Glu Ser Pro His Thr Tyr 
2145                2150                2155                2160
Val Ser Asp Thr Thr Ser Ser Pro Met Ile Thr Ser Pro Gly Ile Leu 
                2165                2170                2175    
Gln Ala Ser Pro Asn Pro Met Leu Ala Thr Ala Ala Pro Pro Ala Pro 
            2180                2185                2190        
Val His Ala Gln His Ala Leu Ser Phe Ser Asn Leu His Glu Met Gln 
        2195                2200                2205            
Pro Leu Ala His Gly Ala Ser Thr Val Leu Pro Ser Val Ser Gln Leu 
    2210                2215                2220                
Leu Ser His His His Ile Val Ser Pro Gly Ser Gly Ser Ala Gly Ser 
2225                2230                2235                2240
Leu Ser Arg Leu His Pro Val Pro Val Pro Ala Asp Trp Met Asn Arg 
                2245                2250                2255    
Met Glu Val Asn Glu Thr Gln Tyr Asn Glu Met Phe Gly Met Val Leu 
            2260                2265                2270        
Ala Pro Ala Glu Gly Thr His Pro Gly Ile Ala Pro Gln Ser Arg Pro 
        2275                2280                2285            
Pro Glu Gly Lys His Ile Thr Thr Pro Arg Glu Pro Leu Pro Pro Ile 
    2290                2295                2300                
Val Thr Phe Gln Leu Ile Pro Lys Gly Ser Ile Ala Gln Pro Ala Gly 
2305                2310                2315                2320
Ala Pro Gln Pro Gln Ser Thr Cys Pro Pro Ala Val Ala Gly Pro Leu 
                2325                2330                2335    
Pro Thr Met Tyr Gln Ile Pro Glu Met Ala Arg Leu Pro Ser Val Ala 
            2340                2345                2350        
Phe Pro Thr Ala Met Met Pro Gln Gln Asp Gly Gln Val Ala Gln Thr 
        2355                2360                2365            
Ile Leu Pro Ala Tyr His Pro Phe Pro Ala Ser Val Gly Lys Tyr Pro 
    2370                2375                2380                
Thr Pro Pro Ser Gln His Ser Tyr Ala Ser Ser Asn Ala Ala Glu Arg 
2385                2390                2395                2400
Thr Pro Ser His Ser Gly His Leu Gln Gly Glu His Pro Tyr Leu Thr 
                2405                2410                2415    
Pro Ser Pro Glu Ser Pro Asp Gln Trp Ser Ser Ser Ser Pro His Ser 
            2420                2425                2430        
Ala Ser Asp Trp Ser Asp Val Thr Thr Ser Pro Thr Pro Gly Gly Ala 
        2435                2440                2445            
Gly Gly Gly Gln Arg Gly Pro Gly Thr His Met Ser Glu Pro Pro His 
    2450                2455                2460                
Asn Asn Met Gln Val Tyr Ala 
2465                2470    

<210> 87
<211> 884
<212> PRT
<213> Homo sapiens

<220> 
<223> N2TM truncation

<400> 87
Met Val Tyr Pro Tyr Tyr Gly Glu Lys Ser Ala Ala Met Lys Lys Gln 
1               5                   10                  15      
Arg Met Thr Arg Arg Ser Leu Pro Gly Glu Gln Glu Gln Glu Val Ala 
            20                  25                  30          
Gly Ser Lys Val Phe Leu Glu Ile Asp Asn Arg Gln Cys Val Gln Asp 
        35                  40                  45              
Ser Asp His Cys Phe Lys Asn Thr Asp Ala Ala Ala Ala Leu Leu Ala 
    50                  55                  60                  
Ser His Ala Ile Gln Gly Thr Leu Ser Tyr Pro Leu Val Ser Val Val 
65                  70                  75                  80  
Ser Glu Ser Leu Thr Pro Glu Arg Thr Gln Leu Leu Tyr Leu Leu Ala 
                85                  90                  95      
Val Ala Val Val Ile Ile Leu Phe Ile Ile Leu Leu Gly Val Ile Met 
            100                 105                 110         
Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro Glu Gly Phe 
        115                 120                 125             
Thr Leu Arg Arg Asp Ala Ser Asn His Lys Arg Arg Glu Pro Val Gly 
    130                 135                 140                 
Gln Asp Ala Val Gly Leu Lys Asn Leu Ser Val Gln Val Ser Glu Ala 
145                 150                 155                 160 
Asn Leu Ile Gly Thr Gly Thr Ser Glu His Trp Val Asp Asp Glu Gly 
                165                 170                 175     
Pro Gln Pro Lys Lys Val Lys Ala Glu Asp Glu Ala Leu Leu Ser Glu 
            180                 185                 190         
Glu Asp Asp Pro Ile Asp Arg Arg Pro Trp Thr Gln Gln His Leu Glu 
        195                 200                 205             
Ala Ala Asp Ile Arg Arg Thr Pro Ser Leu Ala Leu Thr Pro Pro Gln 
    210                 215                 220                 
Ala Glu Gln Glu Val Asp Val Leu Asp Val Asn Val Arg Gly Pro Asp 
225                 230                 235                 240 
Gly Cys Thr Pro Leu Met Leu Ala Ser Leu Arg Gly Gly Ser Ser Asp 
                245                 250                 255     
Leu Ser Asp Glu Asp Glu Asp Ala Glu Asp Ser Ser Ala Asn Ile Ile 
            260                 265                 270         
Thr Asp Leu Val Tyr Gln Gly Ala Ser Leu Gln Ala Gln Thr Asp Arg 
        275                 280                 285             
Thr Gly Glu Met Ala Leu His Leu Ala Ala Arg Tyr Ser Arg Ala Asp 
    290                 295                 300                 
Ala Ala Lys Arg Leu Leu Asp Ala Gly Ala Asp Ala Asn Ala Gln Asp 
305                 310                 315                 320 
Asn Met Gly Arg Cys Pro Leu His Ala Ala Val Ala Ala Asp Ala Gln 
                325                 330                 335     
Gly Val Phe Gln Ile Leu Ile Arg Asn Arg Val Thr Asp Leu Asp Ala 
            340                 345                 350         
Arg Met Asn Asp Gly Thr Thr Pro Leu Ile Leu Ala Ala Arg Leu Ala 
        355                 360                 365             
Val Glu Gly Met Val Ala Glu Leu Ile Asn Cys Gln Ala Asp Val Asn 
    370                 375                 380                 
Ala Val Asp Asp His Gly Lys Ser Ala Leu His Trp Ala Ala Ala Val 
385                 390                 395                 400 
Asn Asn Val Glu Ala Thr Leu Leu Leu Leu Lys Asn Gly Ala Asn Arg 
                405                 410                 415     
Asp Met Gln Asp Asn Lys Glu Glu Thr Pro Leu Phe Leu Ala Ala Arg 
            420                 425                 430         
Glu Gly Ser Tyr Glu Ala Ala Lys Ile Leu Leu Asp His Phe Ala Asn 
        435                 440                 445             
Arg Asp Ile Thr Asp His Met Asp Arg Leu Pro Arg Asp Val Ala Arg 
    450                 455                 460                 
Asp Arg Met His His Asp Ile Val Arg Leu Leu Asp Glu Tyr Asn Val 
465                 470                 475                 480 
Thr Pro Ser Pro Pro Gly Thr Val Leu Thr Ser Ala Leu Ser Pro Val 
                485                 490                 495     
Ile Cys Gly Pro Asn Arg Ser Phe Leu Ser Leu Lys His Thr Pro Met 
            500                 505                 510         
Gly Lys Lys Ser Arg Arg Pro Ser Ala Lys Ser Thr Met Pro Thr Ser 
        515                 520                 525             
Leu Pro Asn Leu Ala Lys Glu Ala Lys Asp Ala Lys Gly Ser Arg Arg 
    530                 535                 540                 
Lys Lys Ser Leu Ser Glu Lys Val Gln Leu Ser Glu Ser Ser Val Thr 
545                 550                 555                 560 
Leu Ser Pro Val Asp Ser Leu Glu Ser Pro His Thr Tyr Val Ser Asp 
                565                 570                 575     
Thr Thr Ser Ser Pro Met Ile Thr Ser Pro Gly Ile Leu Gln Ala Ser 
            580                 585                 590         
Pro Asn Pro Met Leu Ala Thr Ala Ala Pro Pro Ala Pro Val His Ala 
        595                 600                 605             
Gln His Ala Leu Ser Phe Ser Asn Leu His Glu Met Gln Pro Leu Ala 
    610                 615                 620                 
His Gly Ala Ser Thr Val Leu Pro Ser Val Ser Gln Leu Leu Ser His 
625                 630                 635                 640 
His His Ile Val Ser Pro Gly Ser Gly Ser Ala Gly Ser Leu Ser Arg 
                645                 650                 655     
Leu His Pro Val Pro Val Pro Ala Asp Trp Met Asn Arg Met Glu Val 
            660                 665                 670         
Asn Glu Thr Gln Tyr Asn Glu Met Phe Gly Met Val Leu Ala Pro Ala 
        675                 680                 685             
Glu Gly Thr His Pro Gly Ile Ala Pro Gln Ser Arg Pro Pro Glu Gly 
    690                 695                 700                 
Lys His Ile Thr Thr Pro Arg Glu Pro Leu Pro Pro Ile Val Thr Phe 
705                 710                 715                 720 
Gln Leu Ile Pro Lys Gly Ser Ile Ala Gln Pro Ala Gly Ala Pro Gln 
                725                 730                 735     
Pro Gln Ser Thr Cys Pro Pro Ala Val Ala Gly Pro Leu Pro Thr Met 
            740                 745                 750         
Tyr Gln Ile Pro Glu Met Ala Arg Leu Pro Ser Val Ala Phe Pro Thr 
        755                 760                 765             
Ala Met Met Pro Gln Gln Asp Gly Gln Val Ala Gln Thr Ile Leu Pro 
    770                 775                 780                 
Ala Tyr His Pro Phe Pro Ala Ser Val Gly Lys Tyr Pro Thr Pro Pro 
785                 790                 795                 800 
Ser Gln His Ser Tyr Ala Ser Ser Asn Ala Ala Glu Arg Thr Pro Ser 
                805                 810                 815     
His Ser Gly His Leu Gln Gly Glu His Pro Tyr Leu Thr Pro Ser Pro 
            820                 825                 830         
Glu Ser Pro Asp Gln Trp Ser Ser Ser Ser Pro His Ser Ala Ser Asp 
        835                 840                 845             
Trp Ser Asp Val Thr Thr Ser Pro Thr Pro Gly Gly Ala Gly Gly Gly 
    850                 855                 860                 
Gln Arg Gly Pro Gly Thr His Met Ser Glu Pro Pro His Asn Asn Met 
865                 870                 875                 880 
Gln Val Tyr Ala 
                

<210> 88
<211> 773
<212> PRT
<213> Homo sapiens

<220> 
<223> N2IC truncation

<400> 88
Met Ala Lys Arg Lys Arg Lys His Gly Ser Leu Trp Leu Pro Glu Gly 
1               5                   10                  15      
Phe Thr Leu Arg Arg Asp Ala Ser Asn His Lys Arg Arg Glu Pro Val 
            20                  25                  30          
Gly Gln Asp Ala Val Gly Leu Lys Asn Leu Ser Val Gln Val Ser Glu 
        35                  40                  45              
Ala Asn Leu Ile Gly Thr Gly Thr Ser Glu His Trp Val Asp Asp Glu 
    50                  55                  60                  
Gly Pro Gln Pro Lys Lys Val Lys Ala Glu Asp Glu Ala Leu Leu Ser 
65                  70                  75                  80  
Glu Glu Asp Asp Pro Ile Asp Arg Arg Pro Trp Thr Gln Gln His Leu 
                85                  90                  95      
Glu Ala Ala Asp Ile Arg Arg Thr Pro Ser Leu Ala Leu Thr Pro Pro 
            100                 105                 110         
Gln Ala Glu Gln Glu Val Asp Val Leu Asp Val Asn Val Arg Gly Pro 
        115                 120                 125             
Asp Gly Cys Thr Pro Leu Met Leu Ala Ser Leu Arg Gly Gly Ser Ser 
    130                 135                 140                 
Asp Leu Ser Asp Glu Asp Glu Asp Ala Glu Asp Ser Ser Ala Asn Ile 
145                 150                 155                 160 
Ile Thr Asp Leu Val Tyr Gln Gly Ala Ser Leu Gln Ala Gln Thr Asp 
                165                 170                 175     
Arg Thr Gly Glu Met Ala Leu His Leu Ala Ala Arg Tyr Ser Arg Ala 
            180                 185                 190         
Asp Ala Ala Lys Arg Leu Leu Asp Ala Gly Ala Asp Ala Asn Ala Gln 
        195                 200                 205             
Asp Asn Met Gly Arg Cys Pro Leu His Ala Ala Val Ala Ala Asp Ala 
    210                 215                 220                 
Gln Gly Val Phe Gln Ile Leu Ile Arg Asn Arg Val Thr Asp Leu Asp 
225                 230                 235                 240 
Ala Arg Met Asn Asp Gly Thr Thr Pro Leu Ile Leu Ala Ala Arg Leu 
                245                 250                 255     
Ala Val Glu Gly Met Val Ala Glu Leu Ile Asn Cys Gln Ala Asp Val 
            260                 265                 270         
Asn Ala Val Asp Asp His Gly Lys Ser Ala Leu His Trp Ala Ala Ala 
        275                 280                 285             
Val Asn Asn Val Glu Ala Thr Leu Leu Leu Leu Lys Asn Gly Ala Asn 
    290                 295                 300                 
Arg Asp Met Gln Asp Asn Lys Glu Glu Thr Pro Leu Phe Leu Ala Ala 
305                 310                 315                 320 
Arg Glu Gly Ser Tyr Glu Ala Ala Lys Ile Leu Leu Asp His Phe Ala 
                325                 330                 335     
Asn Arg Asp Ile Thr Asp His Met Asp Arg Leu Pro Arg Asp Val Ala 
            340                 345                 350         
Arg Asp Arg Met His His Asp Ile Val Arg Leu Leu Asp Glu Tyr Asn 
        355                 360                 365             
Val Thr Pro Ser Pro Pro Gly Thr Val Leu Thr Ser Ala Leu Ser Pro 
    370                 375                 380                 
Val Ile Cys Gly Pro Asn Arg Ser Phe Leu Ser Leu Lys His Thr Pro 
385                 390                 395                 400 
Met Gly Lys Lys Ser Arg Arg Pro Ser Ala Lys Ser Thr Met Pro Thr 
                405                 410                 415     
Ser Leu Pro Asn Leu Ala Lys Glu Ala Lys Asp Ala Lys Gly Ser Arg 
            420                 425                 430         
Arg Lys Lys Ser Leu Ser Glu Lys Val Gln Leu Ser Glu Ser Ser Val 
        435                 440                 445             
Thr Leu Ser Pro Val Asp Ser Leu Glu Ser Pro His Thr Tyr Val Ser 
    450                 455                 460                 
Asp Thr Thr Ser Ser Pro Met Ile Thr Ser Pro Gly Ile Leu Gln Ala 
465                 470                 475                 480 
Ser Pro Asn Pro Met Leu Ala Thr Ala Ala Pro Pro Ala Pro Val His 
                485                 490                 495     
Ala Gln His Ala Leu Ser Phe Ser Asn Leu His Glu Met Gln Pro Leu 
            500                 505                 510         
Ala His Gly Ala Ser Thr Val Leu Pro Ser Val Ser Gln Leu Leu Ser 
        515                 520                 525             
His His His Ile Val Ser Pro Gly Ser Gly Ser Ala Gly Ser Leu Ser 
    530                 535                 540                 
Arg Leu His Pro Val Pro Val Pro Ala Asp Trp Met Asn Arg Met Glu 
545                 550                 555                 560 
Val Asn Glu Thr Gln Tyr Asn Glu Met Phe Gly Met Val Leu Ala Pro 
                565                 570                 575     
Ala Glu Gly Thr His Pro Gly Ile Ala Pro Gln Ser Arg Pro Pro Glu 
            580                 585                 590         
Gly Lys His Ile Thr Thr Pro Arg Glu Pro Leu Pro Pro Ile Val Thr 
        595                 600                 605             
Phe Gln Leu Ile Pro Lys Gly Ser Ile Ala Gln Pro Ala Gly Ala Pro 
    610                 615                 620                 
Gln Pro Gln Ser Thr Cys Pro Pro Ala Val Ala Gly Pro Leu Pro Thr 
625                 630                 635                 640 
Met Tyr Gln Ile Pro Glu Met Ala Arg Leu Pro Ser Val Ala Phe Pro 
                645                 650                 655     
Thr Ala Met Met Pro Gln Gln Asp Gly Gln Val Ala Gln Thr Ile Leu 
            660                 665                 670         
Pro Ala Tyr His Pro Phe Pro Ala Ser Val Gly Lys Tyr Pro Thr Pro 
        675                 680                 685             
Pro Ser Gln His Ser Tyr Ala Ser Ser Asn Ala Ala Glu Arg Thr Pro 
    690                 695                 700                 
Ser His Ser Gly His Leu Gln Gly Glu His Pro Tyr Leu Thr Pro Ser 
705                 710                 715                 720 
Pro Glu Ser Pro Asp Gln Trp Ser Ser Ser Ser Pro His Ser Ala Ser 
                725                 730                 735     
Asp Trp Ser Asp Val Thr Thr Ser Pro Thr Pro Gly Gly Ala Gly Gly 
            740                 745                 750         
Gly Gln Arg Gly Pro Gly Thr His Met Ser Glu Pro Pro His Asn Asn 
        755                 760                 765             
Met Gln Val Tyr Ala 
    770             

