                         SEQUENCE LISTING

<110>  Aarhus Universitet
 
<120>  Modulation of IFI16 and STING activity

<130>  P4294PC00

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  86
<212>  PRT
<213>  Human

<400>  1

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp Leu Lys 
            20                  25                  30          


Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile Ala Asp 
        35                  40                  45              


Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys Leu Ile 
    50                  55                  60                  


Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu Thr Leu 
65                  70                  75                  80  


Lys Lys Glu Lys Leu Lys 
                85      


<210>  2
<211>  789
<212>  PRT
<213>  Human

<400>  2

Met Ser Val Lys Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys 
1               5                   10                  15      


Gly Leu Glu Val Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu 
            20                  25                  30          


Leu Ser Asn Asp Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp 
        35                  40                  45              


Lys Ile Gln Ile Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala 
    50                  55                  60                  


Gly Leu Gly Lys Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Ala Glu Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro 
                85                  90                  95      


Ala Leu Ser Arg Lys Arg Lys Lys Glu Val Asp Ala Thr Ser Pro Ala 
            100                 105                 110         


Pro Ser Thr Ser Ser Thr Val Lys Thr Glu Gly Ala Glu Ala Thr Pro 
        115                 120                 125             


Gly Ala Gln Lys Arg Lys Lys Ser Thr Lys Glu Lys Ala Gly Pro Lys 
    130                 135                 140                 


Gly Ser Lys Val Ser Glu Glu Gln Thr Gln Pro Pro Ser Pro Ala Gly 
145                 150                 155                 160 


Ala Gly Met Ser Thr Ala Met Gly Arg Ser Pro Ser Pro Lys Thr Ser 
                165                 170                 175     


Leu Ser Ala Pro Pro Asn Ser Ser Ser Thr Glu Asn Pro Lys Thr Val 
            180                 185                 190         


Ala Lys Cys Gln Val Thr Pro Arg Arg Asn Val Leu Gln Lys Arg Pro 
        195                 200                 205             


Val Ile Val Lys Val Leu Ser Thr Thr Lys Pro Phe Glu Tyr Glu Thr 
    210                 215                 220                 


Pro Glu Met Glu Lys Lys Ile Met Phe His Ala Thr Val Ala Thr Gln 
225                 230                 235                 240 


Thr Gln Phe Phe His Val Lys Val Leu Asn Thr Ser Leu Lys Glu Lys 
                245                 250                 255     


Phe Asn Gly Lys Lys Ile Ile Ile Ile Ser Asp Tyr Leu Glu Tyr Asp 
            260                 265                 270         


Ser Leu Leu Glu Val Asn Glu Glu Ser Thr Val Ser Glu Ala Gly Pro 
        275                 280                 285             


Asn Gln Thr Phe Glu Val Pro Asn Lys Ile Ile Asn Arg Ala Lys Glu 
    290                 295                 300                 


Thr Leu Lys Ile Asp Ile Leu His Lys Gln Ala Ser Gly Asn Ile Val 
305                 310                 315                 320 


Tyr Gly Val Phe Met Leu His Lys Lys Thr Val Asn Gln Lys Thr Thr 
                325                 330                 335     


Ile Tyr Glu Ile Gln Asp Asp Arg Gly Lys Met Asp Val Val Gly Thr 
            340                 345                 350         


Gly Gln Cys His Asn Ile Pro Cys Glu Glu Gly Asp Lys Leu Gln Leu 
        355                 360                 365             


Phe Cys Phe Arg Leu Arg Lys Lys Asn Gln Met Ser Lys Leu Ile Ser 
    370                 375                 380                 


Glu Met His Ser Phe Ile Gln Ile Lys Lys Lys Thr Asn Pro Arg Asn 
385                 390                 395                 400 


Asn Asp Pro Lys Ser Met Lys Leu Pro Gln Glu Gln Arg Gln Leu Pro 
                405                 410                 415     


Tyr Pro Ser Glu Ala Ser Thr Thr Phe Pro Glu Ser His Leu Arg Thr 
            420                 425                 430         


Pro Gln Met Pro Pro Thr Thr Pro Ser Ser Ser Phe Phe Thr Lys Lys 
        435                 440                 445             


Ser Glu Asp Thr Ile Ser Lys Met Asn Asp Phe Met Arg Met Gln Ile 
    450                 455                 460                 


Leu Lys Glu Gly Ser His Phe Pro Gly Pro Phe Met Thr Ser Ile Gly 
465                 470                 475                 480 


Pro Ala Glu Ser His Pro His Thr Pro Gln Met Pro Pro Ser Thr Pro 
                485                 490                 495     


Ser Ser Ser Phe Leu Thr Thr Lys Ser Glu Asp Thr Ile Ser Lys Met 
            500                 505                 510         


Asn Asp Phe Met Arg Met Gln Ile Leu Lys Glu Gly Ser His Phe Pro 
        515                 520                 525             


Gly Pro Phe Met Thr Ser Ile Gly Pro Ala Glu Ser His Pro His Thr 
    530                 535                 540                 


Pro Gln Met Pro Pro Ser Thr Pro Ser Ser Ser Phe Leu Thr Thr Leu 
545                 550                 555                 560 


Lys Pro Arg Leu Lys Thr Glu Pro Glu Glu Val Ser Ile Glu Asp Ser 
                565                 570                 575     


Ala Gln Ser Asp Leu Lys Glu Val Met Val Leu Asn Ala Thr Glu Ser 
            580                 585                 590         


Phe Val Tyr Glu Pro Lys Glu Gln Lys Lys Met Phe His Ala Thr Val 
        595                 600                 605             


Ala Thr Glu Asn Glu Val Phe Arg Val Lys Val Phe Asn Ile Asp Leu 
    610                 615                 620                 


Lys Glu Lys Phe Thr Pro Lys Lys Ile Ile Ala Ile Ala Asn Tyr Val 
625                 630                 635                 640 


Cys Arg Asn Gly Phe Leu Glu Val Tyr Pro Phe Thr Leu Val Ala Asp 
                645                 650                 655     


Val Asn Ala Asp Arg Asn Met Glu Ile Pro Lys Gly Leu Ile Arg Ser 
            660                 665                 670         


Ala Ser Val Thr Pro Lys Ile Asn Gln Leu Cys Ser Gln Thr Lys Gly 
        675                 680                 685             


Ser Phe Val Asn Gly Val Phe Glu Val His Lys Lys Asn Val Arg Gly 
    690                 695                 700                 


Glu Phe Thr Tyr Tyr Glu Ile Gln Asp Asn Thr Gly Lys Met Glu Val 
705                 710                 715                 720 


Val Val His Gly Arg Leu Thr Thr Ile Asn Cys Glu Glu Gly Asp Lys 
                725                 730                 735     


Leu Lys Leu Thr Cys Phe Glu Leu Ala Pro Lys Ser Gly Asn Thr Gly 
            740                 745                 750         


Glu Leu Arg Ser Val Ile His Ser His Ile Lys Val Ile Lys Thr Arg 
        755                 760                 765             


Lys Asn Lys Lys Asp Ile Leu Asn Pro Asp Ser Ser Met Glu Thr Ser 
    770                 775                 780                 


Pro Asp Phe Phe Phe 
785                 


<210>  3
<211>  729
<212>  PRT
<213>  Human

<400>  3

Met Gln Ser Thr Ser Asn His Leu Trp Leu Leu Ser Asp Ile Leu Gly 
1               5                   10                  15      


Gln Gly Ala Thr Ala Asn Val Phe Arg Gly Arg His Lys Lys Thr Gly 
            20                  25                  30          


Asp Leu Phe Ala Ile Lys Val Phe Asn Asn Ile Ser Phe Leu Arg Pro 
        35                  40                  45              


Val Asp Val Gln Met Arg Glu Phe Glu Val Leu Lys Lys Leu Asn His 
    50                  55                  60                  


Lys Asn Ile Val Lys Leu Phe Ala Ile Glu Glu Glu Thr Thr Thr Arg 
65                  70                  75                  80  


His Lys Val Leu Ile Met Glu Phe Cys Pro Cys Gly Ser Leu Tyr Thr 
                85                  90                  95      


Val Leu Glu Glu Pro Ser Asn Ala Tyr Gly Leu Pro Glu Ser Glu Phe 
            100                 105                 110         


Leu Ile Val Leu Arg Asp Val Val Gly Gly Met Asn His Leu Arg Glu 
        115                 120                 125             


Asn Gly Ile Val His Arg Asp Ile Lys Pro Gly Asn Ile Met Arg Val 
    130                 135                 140                 


Ile Gly Glu Asp Gly Gln Ser Val Tyr Lys Leu Thr Asp Phe Gly Ala 
145                 150                 155                 160 


Ala Arg Glu Leu Glu Asp Asp Glu Gln Phe Val Ser Leu Tyr Gly Thr 
                165                 170                 175     


Glu Glu Tyr Leu His Pro Asp Met Tyr Glu Arg Ala Val Leu Arg Lys 
            180                 185                 190         


Asp His Gln Lys Lys Tyr Gly Ala Thr Val Asp Leu Trp Ser Ile Gly 
        195                 200                 205             


Val Thr Phe Tyr His Ala Ala Thr Gly Ser Leu Pro Phe Arg Pro Phe 
    210                 215                 220                 


Glu Gly Pro Arg Arg Asn Lys Glu Val Met Tyr Lys Ile Ile Thr Gly 
225                 230                 235                 240 


Lys Pro Ser Gly Ala Ile Ser Gly Val Gln Lys Ala Glu Asn Gly Pro 
                245                 250                 255     


Ile Asp Trp Ser Gly Asp Met Pro Val Ser Cys Ser Leu Ser Arg Gly 
            260                 265                 270         


Leu Gln Val Leu Leu Thr Pro Val Leu Ala Asn Ile Leu Glu Ala Asp 
        275                 280                 285             


Gln Glu Lys Cys Trp Gly Phe Asp Gln Phe Phe Ala Glu Thr Ser Asp 
    290                 295                 300                 


Ile Leu His Arg Met Val Ile His Val Phe Ser Leu Gln Gln Met Thr 
305                 310                 315                 320 


Ala His Lys Ile Tyr Ile His Ser Tyr Asn Thr Ala Thr Ile Phe His 
                325                 330                 335     


Glu Leu Val Tyr Lys Gln Thr Lys Ile Ile Ser Ser Asn Gln Glu Leu 
            340                 345                 350         


Ile Tyr Glu Gly Arg Arg Leu Val Leu Glu Pro Gly Arg Leu Ala Gln 
        355                 360                 365             


His Phe Pro Lys Thr Thr Glu Glu Asn Pro Ile Phe Val Val Ser Arg 
    370                 375                 380                 


Glu Pro Leu Asn Thr Ile Gly Leu Ile Tyr Glu Lys Ile Ser Leu Pro 
385                 390                 395                 400 


Lys Val His Pro Arg Tyr Asp Leu Asp Gly Asp Ala Ser Met Ala Lys 
                405                 410                 415     


Ala Ile Thr Gly Val Val Cys Tyr Ala Cys Arg Ile Ala Ser Thr Leu 
            420                 425                 430         


Leu Leu Tyr Gln Glu Leu Met Arg Lys Gly Ile Arg Trp Leu Ile Glu 
        435                 440                 445             


Leu Ile Lys Asp Asp Tyr Asn Glu Thr Val His Lys Lys Thr Glu Val 
    450                 455                 460                 


Val Ile Thr Leu Asp Phe Cys Ile Arg Asn Ile Glu Lys Thr Val Lys 
465                 470                 475                 480 


Val Tyr Glu Lys Leu Met Lys Ile Asn Leu Glu Ala Ala Glu Leu Gly 
                485                 490                 495     


Glu Ile Ser Asp Ile His Thr Lys Leu Leu Arg Leu Ser Ser Ser Gln 
            500                 505                 510         


Gly Thr Ile Glu Thr Ser Leu Gln Asp Ile Asp Ser Arg Leu Ser Pro 
        515                 520                 525             


Gly Gly Ser Leu Ala Asp Ala Trp Ala His Gln Glu Gly Thr His Pro 
    530                 535                 540                 


Lys Asp Arg Asn Val Glu Lys Leu Gln Val Leu Leu Asn Cys Met Thr 
545                 550                 555                 560 


Glu Ile Tyr Tyr Gln Phe Lys Lys Asp Lys Ala Glu Arg Arg Leu Ala 
                565                 570                 575     


Tyr Asn Glu Glu Gln Ile His Lys Phe Asp Lys Gln Lys Leu Tyr Tyr 
            580                 585                 590         


His Ala Thr Lys Ala Met Thr His Phe Thr Asp Glu Cys Val Lys Lys 
        595                 600                 605             


Tyr Glu Ala Phe Leu Asn Lys Ser Glu Glu Trp Ile Arg Lys Met Leu 
    610                 615                 620                 


His Leu Arg Lys Gln Leu Leu Ser Leu Thr Asn Gln Cys Phe Asp Ile 
625                 630                 635                 640 


Glu Glu Glu Val Ser Lys Tyr Gln Glu Tyr Thr Asn Glu Leu Gln Glu 
                645                 650                 655     


Thr Leu Pro Gln Lys Met Phe Thr Ala Ser Ser Gly Ile Lys His Thr 
            660                 665                 670         


Met Thr Pro Ile Tyr Pro Ser Ser Asn Thr Leu Val Glu Met Thr Leu 
        675                 680                 685             


Gly Met Lys Lys Leu Lys Glu Glu Met Glu Gly Val Val Lys Glu Leu 
    690                 695                 700                 


Ala Glu Asn Asn His Ile Leu Glu Arg Phe Gly Ser Leu Thr Met Asp 
705                 710                 715                 720 


Gly Gly Leu Arg Asn Val Asp Cys Leu 
                725                 


<210>  4
<211>  379
<212>  PRT
<213>  Human

<400>  4

Met Pro His Ser Ser Leu His Pro Ser Ile Pro Cys Pro Arg Gly His 
1               5                   10                  15      


Gly Ala Gln Lys Ala Ala Leu Val Leu Leu Ser Ala Cys Leu Val Thr 
            20                  25                  30          


Leu Trp Gly Leu Gly Glu Pro Pro Glu His Thr Leu Arg Tyr Leu Val 
        35                  40                  45              


Leu His Leu Ala Ser Leu Gln Leu Gly Leu Leu Leu Asn Gly Val Cys 
    50                  55                  60                  


Ser Leu Ala Glu Glu Leu Arg His Ile His Ser Arg Tyr Arg Gly Ser 
65                  70                  75                  80  


Tyr Trp Arg Thr Val Arg Ala Cys Leu Gly Cys Pro Leu Arg Arg Gly 
                85                  90                  95      


Ala Leu Leu Leu Leu Ser Ile Tyr Phe Tyr Tyr Ser Leu Pro Asn Ala 
            100                 105                 110         


Val Gly Pro Pro Phe Thr Trp Met Leu Ala Leu Leu Gly Leu Ser Gln 
        115                 120                 125             


Ala Leu Asn Ile Leu Leu Gly Leu Lys Gly Leu Ala Pro Ala Glu Ile 
    130                 135                 140                 


Ser Ala Val Cys Glu Lys Gly Asn Phe Asn Val Ala His Gly Leu Ala 
145                 150                 155                 160 


Trp Ser Tyr Tyr Ile Gly Tyr Leu Arg Leu Ile Leu Pro Glu Leu Gln 
                165                 170                 175     


Ala Arg Ile Arg Thr Tyr Asn Gln His Tyr Asn Asn Leu Leu Arg Gly 
            180                 185                 190         


Ala Val Ser Gln Arg Leu Tyr Ile Leu Leu Pro Leu Asp Cys Gly Val 
        195                 200                 205             


Pro Asp Asn Leu Ser Met Ala Asp Pro Asn Ile Arg Phe Leu Asp Lys 
    210                 215                 220                 


Leu Pro Gln Gln Thr Gly Asp His Ala Gly Ile Lys Asp Arg Val Tyr 
225                 230                 235                 240 


Ser Asn Ser Ile Tyr Glu Leu Leu Glu Asn Gly Gln Arg Ala Gly Thr 
                245                 250                 255     


Cys Val Leu Glu Tyr Ala Thr Pro Leu Gln Thr Leu Phe Ala Met Ser 
            260                 265                 270         


Gln Tyr Ser Gln Ala Gly Phe Ser Arg Glu Asp Arg Leu Glu Gln Ala 
        275                 280                 285             


Lys Leu Phe Cys Arg Thr Leu Glu Asp Ile Leu Ala Asp Ala Pro Glu 
    290                 295                 300                 


Ser Gln Asn Asn Cys Arg Leu Ile Ala Tyr Gln Glu Pro Ala Asp Asp 
305                 310                 315                 320 


Ser Ser Phe Ser Leu Ser Gln Glu Val Leu Arg His Leu Arg Gln Glu 
                325                 330                 335     


Glu Lys Glu Glu Val Thr Val Gly Ser Leu Lys Thr Ser Ala Val Pro 
            340                 345                 350         


Ser Thr Ser Thr Met Ser Gln Glu Pro Glu Leu Leu Ile Ser Gly Met 
        355                 360                 365             


Glu Lys Pro Leu Pro Leu Arg Thr Asp Phe Ser 
    370                 375                 


<210>  5
<211>  32
<212>  PRT
<213>  Human

<400>  5

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
            20                  25                  30          


<210>  6
<211>  32
<212>  PRT
<213>  Human

<400>  6

Leu Glu Val Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu 
1               5                   10                  15      


Ser Asn Asp Leu Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
            20                  25                  30          


<210>  7
<211>  32
<212>  PRT
<213>  Human

<400>  7

Leu Leu Ser Asn Asp Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr 
1               5                   10                  15      


Asp Lys Ile Gln Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
            20                  25                  30          


<210>  8
<211>  31
<212>  PRT
<213>  Human

<400>  8

Glu Glu Tyr Asp Lys Ile Gln Ile Ala Asp Leu Met Glu Glu Lys Phe 
1               5                   10                  15      


Arg Gly Asp Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
            20                  25                  30      


<210>  9
<211>  32
<212>  PRT
<213>  Human

<400>  9

Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys Leu 
1               5                   10                  15      


Ile Lys Ile Phe Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
            20                  25                  30          


<210>  10
<211>  32
<212>  PRT
<213>  Human

<400>  10

Ala Gly Leu Gly Lys Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu 
1               5                   10                  15      


Glu Asp Leu Ala Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
            20                  25                  30          


<210>  11
<211>  31
<212>  PRT
<213>  Human

<400>  11

Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu Thr Leu Lys Lys Glu 
1               5                   10                  15      


Lys Leu Lys Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
            20                  25                  30      


<210>  12
<211>  70
<212>  PRT
<213>  Human

<400>  12

Asn Asp Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile 
1               5                   10                  15      


Gln Ile Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu 
            20                  25                  30          


Gly Lys Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp Leu 
        35                  40                  45              


Ala Glu Thr Leu Lys Lys Glu Lys Leu Lys Gly Arg Lys Lys Arg Arg 
    50                  55                  60                  


Gln Arg Arg Arg Pro Gln 
65                  70  


<210>  13
<211>  66
<212>  PRT
<213>  Human

<400>  13

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp Leu Lys 
            20                  25                  30          


Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile Ala Asp 
        35                  40                  45              


Leu Met Glu Glu Lys Phe Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
    50                  55                  60                  


Pro Gln 
65      


<210>  14
<211>  62
<212>  PRT
<213>  Human

<400>  14

His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp Leu Lys Leu Asn 
1               5                   10                  15      


Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile Ala Asp Leu Met 
            20                  25                  30          


Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys Leu Ile Lys Ile 
        35                  40                  45              


Phe Glu Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
    50                  55                  60          


<210>  15
<211>  33
<212>  PRT
<213>  Human


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X is a biotin moiety

<400>  15

Xaa Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile 
1               5                   10                  15      


Asn Asp Tyr His Phe Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro 
            20                  25                  30          


Gln 
    


<210>  16
<211>  33
<212>  PRT
<213>  Human


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X is a biotin moiety

<400>  16

Xaa Leu Glu Val Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu 
1               5                   10                  15      


Leu Ser Asn Asp Leu Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro 
            20                  25                  30          


Gln 
    


<210>  17
<211>  33
<212>  PRT
<213>  Human


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X is a biotin moiety

<400>  17

Xaa Leu Leu Ser Asn Asp Leu Lys Leu Asn Leu Lys Met Arg Glu Glu 
1               5                   10                  15      


Tyr Asp Lys Ile Gln Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro 
            20                  25                  30          


Gln 
    


<210>  18
<211>  32
<212>  PRT
<213>  Human


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X is a biotin moiety

<400>  18

Xaa Glu Glu Tyr Asp Lys Ile Gln Ile Ala Asp Leu Met Glu Glu Lys 
1               5                   10                  15      


Phe Arg Gly Asp Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
            20                  25                  30          


<210>  19
<211>  33
<212>  PRT
<213>  Human


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X is a biotin moiety

<400>  19

Xaa Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys 
1               5                   10                  15      


Leu Ile Lys Ile Phe Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro 
            20                  25                  30          


Gln 
    


<210>  20
<211>  33
<212>  PRT
<213>  Human


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X is a biotin moiety

<400>  20

Xaa Ala Gly Leu Gly Lys Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr 
1               5                   10                  15      


Leu Glu Asp Leu Ala Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro 
            20                  25                  30          


Gln 
    


<210>  21
<211>  32
<212>  PRT
<213>  Human


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X is a biotin moiety

<400>  21

Xaa Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu Thr Leu Lys Lys 
1               5                   10                  15      


Glu Lys Leu Lys Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
            20                  25                  30          


<210>  22
<211>  71
<212>  PRT
<213>  Human


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X is a biotin moiety

<400>  22

Xaa Asn Asp Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys 
1               5                   10                  15      


Ile Gln Ile Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly 
            20                  25                  30          


Leu Gly Lys Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp 
        35                  40                  45              


Leu Ala Glu Thr Leu Lys Lys Glu Lys Leu Lys Gly Arg Lys Lys Arg 
    50                  55                  60                  


Arg Gln Arg Arg Arg Pro Gln 
65                  70      


<210>  23
<211>  67
<212>  PRT
<213>  Human


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X is a biotin moiety

<400>  23

Xaa Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile 
1               5                   10                  15      


Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp Leu 
            20                  25                  30          


Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile Ala 
        35                  40                  45              


Asp Leu Met Glu Glu Lys Phe Gly Arg Lys Lys Arg Arg Gln Arg Arg 
    50                  55                  60                  


Arg Pro Gln 
65          


<210>  24
<211>  62
<212>  PRT
<213>  Human

<400>  24

His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp Leu Lys Leu Asn 
1               5                   10                  15      


Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile Ala Asp Leu Met 
            20                  25                  30          


Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys Leu Ile Lys Ile 
        35                  40                  45              


Phe Glu Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
    50                  55                  60          


<210>  25
<211>  32
<212>  PRT
<213>  Human

<400>  25

Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile Asn 
1               5                   10                  15      


Asp Tyr His Phe Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
            20                  25                  30          


<210>  26
<211>  21
<212>  PRT
<213>  Human


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X is a biotin moiety

<400>  26

Xaa Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val Ile 
1               5                   10                  15      


Asn Asp Tyr His Phe 
            20      


<210>  27
<211>  31
<212>  PRT
<213>  Human

<400>  27

Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu Thr Leu Lys Lys Glu 
1               5                   10                  15      


Lys Leu Lys Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Gln 
            20                  25                  30      


<210>  28
<211>  20
<212>  PRT
<213>  Human


<220>
<221>  MISC_FEATURE
<222>  (1)..(2)
<223>  X is a biotin moiety

<400>  28

Xaa Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu Thr Leu Lys Lys 
1               5                   10                  15      


Glu Lys Leu Lys 
            20  


<210>  29
<211>  522
<212>  PRT
<213>  Human

<400>  29

Met Gln Pro Trp His Gly Lys Ala Met Gln Arg Ala Ser Glu Ala Gly 
1               5                   10                  15      


Ala Thr Ala Pro Lys Ala Ser Ala Arg Asn Ala Arg Gly Ala Pro Met 
            20                  25                  30          


Asp Pro Thr Glu Ser Pro Ala Ala Pro Glu Ala Ala Leu Pro Lys Ala 
        35                  40                  45              


Gly Lys Phe Gly Pro Ala Arg Lys Ser Gly Ser Arg Gln Lys Lys Ser 
    50                  55                  60                  


Ala Pro Asp Thr Gln Glu Arg Pro Pro Val Arg Ala Thr Gly Ala Arg 
65                  70                  75                  80  


Ala Lys Lys Ala Pro Gln Arg Ala Gln Asp Thr Gln Pro Ser Asp Ala 
                85                  90                  95      


Thr Ser Ala Pro Gly Ala Glu Gly Leu Glu Pro Pro Ala Ala Arg Glu 
            100                 105                 110         


Pro Ala Leu Ser Arg Ala Gly Ser Cys Arg Gln Arg Gly Ala Arg Cys 
        115                 120                 125             


Ser Thr Lys Pro Arg Pro Pro Pro Gly Pro Trp Asp Val Pro Ser Pro 
    130                 135                 140                 


Gly Leu Pro Val Ser Ala Pro Ile Leu Val Arg Arg Asp Ala Ala Pro 
145                 150                 155                 160 


Gly Ala Ser Lys Leu Arg Ala Val Leu Glu Lys Leu Lys Leu Ser Arg 
                165                 170                 175     


Asp Asp Ile Ser Thr Ala Ala Gly Met Val Lys Gly Val Val Asp His 
            180                 185                 190         


Leu Leu Leu Arg Leu Lys Cys Asp Ser Ala Phe Arg Gly Val Gly Leu 
        195                 200                 205             


Leu Asn Thr Gly Ser Tyr Tyr Glu His Val Lys Ile Ser Ala Pro Asn 
    210                 215                 220                 


Glu Phe Asp Val Met Phe Lys Leu Glu Val Pro Arg Ile Gln Leu Glu 
225                 230                 235                 240 


Glu Tyr Ser Asn Thr Arg Ala Tyr Tyr Phe Val Lys Phe Lys Arg Asn 
                245                 250                 255     


Pro Lys Glu Asn Pro Leu Ser Gln Phe Leu Glu Gly Glu Ile Leu Ser 
            260                 265                 270         


Ala Ser Lys Met Leu Ser Lys Phe Arg Lys Ile Ile Lys Glu Glu Ile 
        275                 280                 285             


Asn Asp Ile Lys Asp Thr Asp Val Ile Met Lys Arg Lys Arg Gly Gly 
    290                 295                 300                 


Ser Pro Ala Val Thr Leu Leu Ile Ser Glu Lys Ile Ser Val Asp Ile 
305                 310                 315                 320 


Thr Leu Ala Leu Glu Ser Lys Ser Ser Trp Pro Ala Ser Thr Gln Glu 
                325                 330                 335     


Gly Leu Arg Ile Gln Asn Trp Leu Ser Ala Lys Val Arg Lys Gln Leu 
            340                 345                 350         


Arg Leu Lys Pro Phe Tyr Leu Val Pro Lys His Ala Lys Glu Gly Asn 
        355                 360                 365             


Gly Phe Gln Glu Glu Thr Trp Arg Leu Ser Phe Ser His Ile Glu Lys 
    370                 375                 380                 


Glu Ile Leu Asn Asn His Gly Lys Ser Lys Thr Cys Cys Glu Asn Lys 
385                 390                 395                 400 


Glu Glu Lys Cys Cys Arg Lys Asp Cys Leu Lys Leu Met Lys Tyr Leu 
                405                 410                 415     


Leu Glu Gln Leu Lys Glu Arg Phe Lys Asp Lys Lys His Leu Asp Lys 
            420                 425                 430         


Phe Ser Ser Tyr His Val Lys Thr Ala Phe Phe His Val Cys Thr Gln 
        435                 440                 445             


Asn Pro Gln Asp Ser Gln Trp Asp Arg Lys Asp Leu Gly Leu Cys Phe 
    450                 455                 460                 


Asp Asn Cys Val Thr Tyr Phe Leu Gln Cys Leu Arg Thr Glu Lys Leu 
465                 470                 475                 480 


Glu Asn Tyr Phe Ile Pro Glu Phe Asn Leu Phe Ser Ser Asn Leu Ile 
                485                 490                 495     


Asp Lys Arg Ser Lys Glu Phe Leu Thr Lys Gln Ile Glu Tyr Glu Arg 
            500                 505                 510         


Asn Asn Glu Phe Pro Val Phe Asp Glu Phe 
        515                 520         


<210>  30
<211>  507
<212>  PRT
<213>  Human

<400>  30

Met Glu Asp Pro Arg Arg Arg Thr Thr Ala Pro Arg Ala Lys Lys Pro 
1               5                   10                  15      


Ser Ala Lys Arg Ala Pro Thr Gln Pro Ser Arg Thr Arg Ala His Ala 
            20                  25                  30          


Glu Ser Cys Gly Pro Gln Arg Gly Ala Arg Ser Arg Arg Ala Glu Arg 
        35                  40                  45              


Asp Gly Asp Thr Thr Glu Lys Pro Arg Ala Pro Gly Pro Arg Val His 
    50                  55                  60                  


Pro Ala Arg Ala Thr Glu Leu Thr Lys Asp Ala Gln Pro Ser Ala Met 
65                  70                  75                  80  


Asp Ala Ala Gly Ala Thr Ala Arg Pro Ala Val Arg Val Pro Gln Gln 
                85                  90                  95      


Gln Ala Ile Leu Asp Pro Glu Leu Pro Ala Val Arg Glu Pro Gln Pro 
            100                 105                 110         


Pro Ala Asp Pro Glu Ala Arg Lys Val Val Arg Gly Pro Ser His Arg 
        115                 120                 125             


Arg Gly Ala Arg Ser Thr Gly Gln Pro Arg Ala Pro Arg Gly Ser Arg 
    130                 135                 140                 


Lys Glu Pro Asp Lys Leu Lys Lys Val Leu Asp Lys Leu Arg Leu Lys 
145                 150                 155                 160 


Arg Lys Asp Ile Ser Glu Ala Ala Glu Thr Val Asn Lys Val Val Glu 
                165                 170                 175     


Arg Leu Leu Arg Arg Met Gln Lys Arg Glu Ser Glu Phe Lys Gly Val 
            180                 185                 190         


Glu Gln Leu Asn Thr Gly Ser Tyr Tyr Glu His Val Lys Ile Ser Ala 
        195                 200                 205             


Pro Asn Glu Phe Asp Val Met Phe Lys Leu Glu Val Pro Arg Ile Glu 
    210                 215                 220                 


Leu Gln Glu Tyr Tyr Glu Thr Gly Ala Phe Tyr Leu Val Lys Phe Lys 
225                 230                 235                 240 


Arg Ile Pro Arg Gly Asn Pro Leu Ser His Phe Leu Glu Gly Glu Val 
                245                 250                 255     


Leu Ser Ala Thr Lys Met Leu Ser Lys Phe Arg Lys Ile Ile Lys Glu 
            260                 265                 270         


Glu Val Lys Glu Ile Lys Asp Ile Asp Val Ser Val Glu Lys Glu Lys 
        275                 280                 285             


Pro Gly Ser Pro Ala Val Thr Leu Leu Ile Arg Asn Pro Glu Glu Ile 
    290                 295                 300                 


Ser Val Asp Ile Ile Leu Ala Leu Glu Ser Lys Gly Ser Trp Pro Ile 
305                 310                 315                 320 


Ser Thr Lys Glu Gly Leu Pro Ile Gln Gly Trp Leu Gly Thr Lys Val 
                325                 330                 335     


Arg Thr Asn Leu Arg Arg Glu Pro Phe Tyr Leu Val Pro Lys Asn Ala 
            340                 345                 350         


Lys Asp Gly Asn Ser Phe Gln Gly Glu Thr Trp Arg Leu Ser Phe Ser 
        355                 360                 365             


His Thr Glu Lys Tyr Ile Leu Asn Asn His Gly Ile Glu Lys Thr Cys 
    370                 375                 380                 


Cys Glu Ser Ser Gly Ala Lys Cys Cys Arg Lys Glu Cys Leu Lys Leu 
385                 390                 395                 400 


Met Lys Tyr Leu Leu Glu Gln Leu Lys Lys Glu Phe Gln Glu Leu Asp 
                405                 410                 415     


Ala Phe Cys Ser Tyr His Val Lys Thr Ala Ile Phe His Met Trp Thr 
            420                 425                 430         


Gln Asp Pro Gln Asp Ser Gln Trp Asp Pro Arg Asn Leu Ser Ser Cys 
        435                 440                 445             


Phe Asp Lys Leu Leu Ala Phe Phe Leu Glu Cys Leu Arg Thr Glu Lys 
    450                 455                 460                 


Leu Asp His Tyr Phe Ile Pro Lys Phe Asn Leu Phe Ser Gln Glu Leu 
465                 470                 475                 480 


Ile Asp Arg Lys Ser Lys Glu Phe Leu Ser Lys Lys Ile Glu Tyr Glu 
                485                 490                 495     


Arg Asn Asn Gly Phe Pro Ile Phe Asp Lys Leu 
            500                 505         


