                         SEQUENCE LISTING

<110>  EVOLVA SA
 
<120>  BIOSYNTHESIS OF BENZYLISOQUINOLINE ALKALOIDS AND 
       BENZYLISOQUINOLINE ALKALOID PRECURSOR

<130>  15-992-WO

<160>  64    

<170>  PatentIn version 3.5

<210>  1
<211>  351
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  1

Met Pro Ser Gln Val Ile Pro Glu Lys Gln Lys Ala Ile Val Phe Tyr 
1               5                   10                  15      


Glu Thr Asp Gly Lys Leu Glu Tyr Lys Asp Val Thr Val Pro Glu Pro 
            20                  25                  30          


Lys Pro Asn Glu Ile Leu Val His Val Lys Tyr Ser Gly Val Cys His 
        35                  40                  45              


Ser Asp Leu His Ala Trp His Gly Asp Trp Pro Phe Gln Leu Lys Phe 
    50                  55                  60                  


Pro Leu Ile Gly Gly His Glu Gly Ala Gly Val Val Val Lys Leu Gly 
65                  70                  75                  80  


Ser Asn Val Lys Gly Trp Lys Val Gly Asp Phe Ala Gly Ile Lys Trp 
                85                  90                  95      


Leu Asn Gly Thr Cys Met Ser Cys Glu Tyr Cys Glu Val Gly Asn Glu 
            100                 105                 110         


Ser Gln Cys Pro Tyr Leu Asp Gly Thr Gly Phe Thr His Asp Gly Thr 
        115                 120                 125             


Phe Gln Glu Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro 
    130                 135                 140                 


Pro Asn Val Asn Leu Ala Glu Val Ala Pro Ile Leu Cys Ala Gly Ile 
145                 150                 155                 160 


Thr Val Tyr Lys Ala Leu Lys Arg Ala Asn Val Ile Pro Gly Gln Trp 
                165                 170                 175     


Val Thr Ile Ser Gly Ala Cys Gly Gly Leu Gly Ser Leu Ala Ile Gln 
            180                 185                 190         


Tyr Ala Leu Ala Met Gly Tyr Arg Val Ile Gly Ile Asp Gly Gly Asn 
        195                 200                 205             


Ala Lys Arg Lys Leu Phe Glu Gln Leu Gly Gly Glu Ile Phe Ile Asp 
    210                 215                 220                 


Phe Thr Glu Glu Lys Asp Ile Val Gly Ala Ile Ile Lys Ala Thr Asn 
225                 230                 235                 240 


Gly Gly Ser His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile 
                245                 250                 255     


Glu Ala Ser Thr Arg Tyr Cys Arg Pro Asn Gly Thr Val Val Leu Val 
            260                 265                 270         


Gly Met Pro Ala His Ala Tyr Cys Asn Ser Asp Val Phe Asn Gln Val 
        275                 280                 285             


Val Lys Ser Ile Ser Ile Val Gly Ser Cys Val Gly Asn Arg Ala Asp 
    290                 295                 300                 


Thr Arg Glu Ala Leu Asp Phe Phe Ala Arg Gly Leu Ile Lys Ser Pro 
305                 310                 315                 320 


Ile His Leu Ala Gly Leu Ser Asp Val Pro Glu Ile Phe Ala Lys Met 
                325                 330                 335     


Glu Lys Gly Glu Ile Val Gly Arg Tyr Val Val Glu Thr Ser Lys 
            340                 345                 350     


<210>  2
<211>  1056
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  2
atgccttcgc aagtcattcc tgaaaaacaa aaggctattg tcttttatga gacagatgga       60

aaattggaat ataaagacgt cacagttccg gaacctaagc ctaacgaaat tttagtccac      120

gttaaatatt ctggtgtttg tcatagtgac ttgcacgcgt ggcacggtga ttggccattt      180

caattgaaat ttccattaat cggtggtcac gaaggtgctg gtgttgttgt taagttggga      240

tctaacgtta agggctggaa agtcggtgat tttgcaggta taaaatggtt gaatgggact      300

tgcatgtcct gtgaatattg tgaagtaggt aatgaatctc aatgtcctta tttggatggt      360

actggcttca cacatgatgg tacttttcaa gaatacgcaa ctgccgatgc cgttcaagct      420

gcccatattc caccaaacgt caatcttgct gaagttgccc caatcttgtg tgcaggtatc      480

actgtttata aggcgttgaa aagagccaat gtgataccag gccaatgggt cactatatcc      540

ggtgcatgcg gtggcttggg ttctctggca atccaatacg cccttgctat gggttacagg      600

gtcattggta tcgatggtgg taatgccaag cgaaagttat ttgaacaatt aggcggagaa      660

atattcatcg atttcacgga agaaaaagac attgttggtg ctataataaa ggccactaat      720

ggcggttctc atggagttat taatgtgtct gtttctgaag cagctatcga ggcttctacg      780

aggtattgta ggcccaatgg tactgtcgtc ctggttggta tgccagctca tgcttactgc      840

aattccgatg ttttcaatca agttgtaaaa tcaatctcca tcgttggatc ttgtgttgga      900

aatagagctg atacaaggga ggctttagat ttcttcgcca gaggtttgat caaatctccg      960

atccacttag ctggcctatc ggatgttcct gaaatttttg caaagatgga gaagggtgaa     1020

attgttggta gatatgttgt tgagacttct aaatga                               1056


<210>  3
<211>  360
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  3

Met Ser Tyr Pro Glu Lys Phe Glu Gly Ile Ala Ile Gln Ser His Glu 
1               5                   10                  15      


Asp Trp Lys Asn Pro Lys Lys Thr Lys Tyr Asp Pro Lys Pro Phe Tyr 
            20                  25                  30          


Asp His Asp Ile Asp Ile Lys Ile Glu Ala Cys Gly Val Cys Gly Ser 
        35                  40                  45              


Asp Ile His Cys Ala Ala Gly His Trp Gly Asn Met Lys Met Pro Leu 
    50                  55                  60                  


Val Val Gly His Glu Ile Val Gly Lys Val Val Lys Leu Gly Pro Lys 
65                  70                  75                  80  


Ser Asn Ser Gly Leu Lys Val Gly Gln Arg Val Gly Val Gly Ala Gln 
                85                  90                  95      


Val Phe Ser Cys Leu Glu Cys Asp Arg Cys Lys Asn Asp Asn Glu Pro 
            100                 105                 110         


Tyr Cys Thr Lys Phe Val Thr Thr Tyr Ser Gln Pro Tyr Glu Asp Gly 
        115                 120                 125             


Tyr Val Ser Gln Gly Gly Tyr Ala Asn Tyr Val Arg Val His Glu His 
    130                 135                 140                 


Phe Val Val Pro Ile Pro Glu Asn Ile Pro Ser His Leu Ala Ala Pro 
145                 150                 155                 160 


Leu Leu Cys Gly Gly Leu Thr Val Tyr Ser Pro Leu Val Arg Asn Gly 
                165                 170                 175     


Cys Gly Pro Gly Lys Lys Val Gly Ile Val Gly Leu Gly Gly Ile Gly 
            180                 185                 190         


Ser Met Gly Thr Leu Ile Ser Lys Ala Met Gly Ala Glu Thr Tyr Val 
        195                 200                 205             


Ile Ser Arg Ser Ser Arg Lys Arg Glu Asp Ala Met Lys Met Gly Ala 
    210                 215                 220                 


Asp His Tyr Ile Ala Thr Leu Glu Glu Gly Asp Trp Gly Glu Lys Tyr 
225                 230                 235                 240 


Phe Asp Thr Phe Asp Leu Ile Val Val Cys Ala Ser Ser Leu Thr Asp 
                245                 250                 255     


Ile Asp Phe Asn Ile Met Pro Lys Ala Met Lys Val Gly Gly Arg Ile 
            260                 265                 270         


Val Ser Ile Ser Ile Pro Glu Gln His Glu Met Leu Ser Leu Lys Pro 
        275                 280                 285             


Tyr Gly Leu Lys Ala Val Ser Ile Ser Tyr Ser Ala Leu Gly Ser Ile 
    290                 295                 300                 


Lys Glu Leu Asn Gln Leu Leu Lys Leu Val Ser Glu Lys Asp Ile Lys 
305                 310                 315                 320 


Ile Trp Val Glu Thr Leu Pro Val Gly Glu Ala Gly Val His Glu Ala 
                325                 330                 335     


Phe Glu Arg Met Glu Lys Gly Asp Val Arg Tyr Arg Phe Thr Leu Val 
            340                 345                 350         


Gly Tyr Asp Lys Glu Phe Ser Asp 
        355                 360 


<210>  4
<211>  1083
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  4
atgtcttatc ctgagaaatt tgaaggtatc gctattcaat cacacgaaga ttggaaaaac       60

ccaaagaaga caaagtatga cccaaaacca ttttacgatc atgacattga cattaagatc      120

gaagcatgtg gtgtctgcgg tagtgatatt cattgtgcag ctggtcattg gggcaatatg      180

aagatgccgc tagtcgttgg tcatgaaatc gttggtaaag ttgtcaagct agggcccaag      240

tcaaacagtg ggttgaaagt cggtcaacgt gttggtgtag gtgctcaagt cttttcatgc      300

ttggaatgtg accgttgtaa gaatgataat gaaccatact gcaccaagtt tgttaccaca      360

tacagtcagc cttatgaaga cggctatgtg tcgcagggtg gctatgcaaa ctacgtcaga      420

gttcatgaac attttgtggt gcctatccca gagaatattc catcacattt ggctgctcca      480

ctattatgtg gtggtttgac tgtgtactct ccattggttc gtaacggttg cggtccaggt      540

aaaaaagttg gtatagttgg tcttggtggt atcggcagta tgggtacatt gatttccaaa      600

gccatggggg cagagacgta tgttatttct cgttcttcga gaaaaagaga agatgcaatg      660

aagatgggcg ccgatcacta cattgctaca ttagaagaag gtgattgggg tgaaaagtac      720

tttgacacct tcgacctgat tgtagtctgt gcttcctccc ttaccgacat tgacttcaac      780

attatgccaa aggctatgaa ggttggtggt agaattgtct caatctctat accagaacaa      840

cacgaaatgt tatcgctaaa gccatatggc ttaaaggctg tctccatttc ttacagtgct      900

ttaggttcca tcaaagaatt gaaccaactc ttgaaattag tctctgaaaa agatatcaaa      960

atttgggtgg aaacattacc tgttggtgaa gccggcgtcc atgaagcctt cgaaaggatg     1020

gaaaagggtg acgttagata tagatttacc ttagtcggct acgacaaaga attttcagac     1080

tag                                                                   1083


<210>  5
<211>  361
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  5

Met Leu Tyr Pro Glu Lys Phe Gln Gly Ile Gly Ile Ser Asn Ala Lys 
1               5                   10                  15      


Asp Trp Lys His Pro Lys Leu Val Ser Phe Asp Pro Lys Pro Phe Gly 
            20                  25                  30          


Asp His Asp Val Asp Val Glu Ile Glu Ala Cys Gly Ile Cys Gly Ser 
        35                  40                  45              


Asp Phe His Ile Ala Val Gly Asn Trp Gly Pro Val Pro Glu Asn Gln 
    50                  55                  60                  


Ile Leu Gly His Glu Ile Ile Gly Arg Val Val Lys Val Gly Ser Lys 
65                  70                  75                  80  


Cys His Thr Gly Val Lys Ile Gly Asp Arg Val Gly Val Gly Ala Gln 
                85                  90                  95      


Ala Leu Ala Cys Phe Glu Cys Glu Arg Cys Lys Ser Asp Asn Glu Gln 
            100                 105                 110         


Tyr Cys Thr Asn Asp His Val Leu Thr Met Trp Thr Pro Tyr Lys Asp 
        115                 120                 125             


Gly Tyr Ile Ser Gln Gly Gly Phe Ala Ser His Val Arg Leu His Glu 
    130                 135                 140                 


His Phe Ala Ile Gln Ile Pro Glu Asn Ile Pro Ser Pro Leu Ala Ala 
145                 150                 155                 160 


Pro Leu Leu Cys Gly Gly Ile Thr Val Phe Ser Pro Leu Leu Arg Asn 
                165                 170                 175     


Gly Cys Gly Pro Gly Lys Arg Val Gly Ile Val Gly Ile Gly Gly Ile 
            180                 185                 190         


Gly His Met Gly Ile Leu Leu Ala Lys Ala Met Gly Ala Glu Val Tyr 
        195                 200                 205             


Ala Phe Ser Arg Gly His Ser Lys Arg Glu Asp Ser Met Lys Leu Gly 
    210                 215                 220                 


Ala Asp His Tyr Ile Ala Met Leu Glu Asp Lys Gly Trp Thr Glu Gln 
225                 230                 235                 240 


Tyr Ser Asn Ala Leu Asp Leu Leu Val Val Cys Ser Ser Ser Leu Ser 
                245                 250                 255     


Lys Val Asn Phe Asp Ser Ile Val Lys Ile Met Lys Ile Gly Gly Ser 
            260                 265                 270         


Ile Val Ser Ile Ala Ala Pro Glu Val Asn Glu Lys Leu Val Leu Lys 
        275                 280                 285             


Pro Leu Gly Leu Met Gly Val Ser Ile Ser Ser Ser Ala Ile Gly Ser 
    290                 295                 300                 


Arg Lys Glu Ile Glu Gln Leu Leu Lys Leu Val Ser Glu Lys Asn Val 
305                 310                 315                 320 


Lys Ile Trp Val Glu Lys Leu Pro Ile Ser Glu Glu Gly Val Ser His 
                325                 330                 335     


Ala Phe Thr Arg Met Glu Ser Gly Asp Val Lys Tyr Arg Phe Thr Leu 
            340                 345                 350         


Val Asp Tyr Asp Lys Lys Phe His Lys 
        355                 360     


<210>  6
<211>  1086
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  6
atgctttacc cagaaaaatt tcagggcatc ggtatttcca acgcaaagga ttggaagcat       60

cctaaattag tgagttttga cccaaaaccc tttggcgatc atgacgttga tgttgaaatt      120

gaagcctgtg gtatctgcgg atctgatttt catatagccg ttggtaattg gggtccagtc      180

ccagaaaatc aaatccttgg acatgaaata attggccgcg tggtgaaggt tggatccaag      240

tgccacactg gggtaaaaat cggtgaccgt gttggtgttg gtgcccaagc cttggcgtgt      300

tttgagtgtg aacgttgcaa aagtgacaac gagcaatact gtaccaatga ccacgttttg      360

actatgtgga ctccttacaa ggacggctac atttcacaag gaggctttgc ctcccacgtg      420

aggcttcatg aacactttgc tattcaaata ccagaaaata ttccaagtcc gctagccgct      480

ccattattgt gtggtggtat tacagttttc tctccactac taagaaatgg ctgtggtcca      540

ggtaagaggg taggtattgt tggcatcggt ggtattgggc atatggggat tctgttggct      600

aaagctatgg gagccgaggt ttatgcgttt tcgcgaggcc actccaagcg ggaggattct      660

atgaaactcg gtgctgatca ctatattgct atgttggagg ataaaggctg gacagaacaa      720

tactctaacg ctttggacct tcttgtcgtt tgctcatcat ctttgtcgaa agttaatttt      780

gacagtatcg ttaagattat gaagattgga ggctccatcg tttcaattgc tgctcctgaa      840

gttaatgaaa agcttgtttt aaaaccgttg ggcctaatgg gagtatcaat ctcaagcagt      900

gctatcggat ctaggaagga aatcgaacaa ctattgaaat tagtttccga aaagaatgtc      960

aaaatatggg tggaaaaact tccgatcagc gaagaaggcg tcagccatgc ctttacaagg     1020

atggaaagcg gagacgtcaa atacagattt actttggtcg attatgataa gaaattccat     1080

aaatag                                                                1086


<210>  7
<211>  342
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  7

Met Ser Val Phe Val Ser Gly Ala Asn Gly Phe Ile Ala Gln His Ile 
1               5                   10                  15      


Val Asp Leu Leu Leu Lys Glu Asp Tyr Lys Val Ile Gly Ser Ala Arg 
            20                  25                  30          


Ser Gln Glu Lys Ala Glu Asn Leu Thr Glu Ala Phe Gly Asn Asn Pro 
        35                  40                  45              


Lys Phe Ser Met Glu Val Val Pro Asp Ile Ser Lys Leu Asp Ala Phe 
    50                  55                  60                  


Asp His Val Phe Gln Lys His Gly Lys Asp Ile Lys Ile Val Leu His 
65                  70                  75                  80  


Thr Ala Ser Pro Phe Cys Phe Asp Ile Thr Asp Ser Glu Arg Asp Leu 
                85                  90                  95      


Leu Ile Pro Ala Val Asn Gly Val Lys Gly Ile Leu His Ser Ile Lys 
            100                 105                 110         


Lys Tyr Ala Ala Asp Ser Val Glu Arg Val Val Leu Thr Ser Ser Tyr 
        115                 120                 125             


Ala Ala Val Phe Asp Met Ala Lys Glu Asn Asp Lys Ser Leu Thr Phe 
    130                 135                 140                 


Asn Glu Glu Ser Trp Asn Pro Ala Thr Trp Glu Ser Cys Gln Ser Asp 
145                 150                 155                 160 


Pro Val Asn Ala Tyr Cys Gly Ser Lys Lys Phe Ala Glu Lys Ala Ala 
                165                 170                 175     


Trp Glu Phe Leu Glu Glu Asn Arg Asp Ser Val Lys Phe Glu Leu Thr 
            180                 185                 190         


Ala Val Asn Pro Val Tyr Val Phe Gly Pro Gln Met Phe Asp Lys Asp 
        195                 200                 205             


Val Lys Lys His Leu Asn Thr Ser Cys Glu Leu Val Asn Ser Leu Met 
    210                 215                 220                 


His Leu Ser Pro Glu Asp Lys Ile Pro Glu Leu Phe Gly Gly Tyr Ile 
225                 230                 235                 240 


Asp Val Arg Asp Val Ala Lys Ala His Leu Val Ala Phe Gln Lys Arg 
                245                 250                 255     


Glu Thr Ile Gly Gln Arg Leu Ile Val Ser Glu Ala Arg Phe Thr Met 
            260                 265                 270         


Gln Asp Val Leu Asp Ile Leu Asn Glu Asp Phe Pro Val Leu Lys Gly 
        275                 280                 285             


Asn Ile Pro Val Gly Lys Pro Gly Ser Gly Ala Thr His Asn Thr Leu 
    290                 295                 300                 


Gly Ala Thr Leu Asp Asn Lys Lys Ser Lys Lys Leu Leu Gly Phe Lys 
305                 310                 315                 320 


Phe Arg Asn Leu Lys Glu Thr Ile Asp Asp Thr Ala Ser Gln Ile Leu 
                325                 330                 335     


Lys Phe Glu Gly Arg Ile 
            340         


<210>  8
<211>  1029
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  8
atgtcagttt tcgtttcagg tgctaacggg ttcattgccc aacacattgt cgatctcctg       60

ttgaaggaag actataaggt catcggttct gccagaagtc aagaaaaggc cgagaattta      120

acggaggcct ttggtaacaa cccaaaattc tccatggaag ttgtcccaga catatctaag      180

ctggacgcat ttgaccatgt tttccaaaag cacggcaagg atatcaagat agttctacat      240

acggcctctc cattctgctt tgatatcact gacagtgaac gcgatttatt aattcctgct      300

gtgaacggtg ttaagggaat tctccactca attaaaaaat acgccgctga ttctgtagaa      360

cgtgtagttc tcacctcttc ttatgcagct gtgttcgata tggcaaaaga aaacgataag      420

tctttaacat ttaacgaaga atcctggaac ccagctacct gggagagttg ccaaagtgac      480

ccagttaacg cctactgtgg ttctaagaag tttgctgaaa aagcagcttg ggaatttcta      540

gaggagaata gagactctgt aaaattcgaa ttaactgccg ttaacccagt ttacgttttt      600

ggtccgcaaa tgtttgacaa agatgtgaaa aaacacttga acacatcttg cgaactcgtc      660

aacagcttga tgcatttatc accagaggac aagataccgg aactatttgg tggatacatt      720

gatgttcgtg atgttgcaaa ggctcattta gttgccttcc aaaagaggga aacaattggt      780

caaagactaa tcgtatcgga ggccagattt actatgcagg atgttctcga tatccttaac      840

gaagacttcc ctgttctaaa aggcaatatt ccagtgggga aaccaggttc tggtgctacc      900

cataacaccc ttggtgctac tcttgataat aaaaagagta agaaattgtt aggtttcaag      960

ttcaggaact tgaaagagac cattgacgac actgcctccc aaattttaaa atttgagggc     1020

agaatataa                                                             1029


<210>  9
<211>  327
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  9

Met Ser Ser Leu Val Thr Leu Asn Asn Gly Leu Lys Met Pro Leu Val 
1               5                   10                  15      


Gly Leu Gly Cys Trp Lys Ile Asp Lys Lys Val Cys Ala Asn Gln Ile 
            20                  25                  30          


Tyr Glu Ala Ile Lys Leu Gly Tyr Arg Leu Phe Asp Gly Ala Cys Asp 
        35                  40                  45              


Tyr Gly Asn Glu Lys Glu Val Gly Glu Gly Ile Arg Lys Ala Ile Ser 
    50                  55                  60                  


Glu Gly Leu Val Ser Arg Lys Asp Ile Phe Val Val Ser Lys Leu Trp 
65                  70                  75                  80  


Asn Asn Phe His His Pro Asp His Val Lys Leu Ala Leu Lys Lys Thr 
                85                  90                  95      


Leu Ser Asp Met Gly Leu Asp Tyr Leu Asp Leu Tyr Tyr Ile His Phe 
            100                 105                 110         


Pro Ile Ala Phe Lys Tyr Val Pro Phe Glu Glu Lys Tyr Pro Pro Gly 
        115                 120                 125             


Phe Tyr Thr Gly Ala Asp Asp Glu Lys Lys Gly His Ile Thr Glu Ala 
    130                 135                 140                 


His Val Pro Ile Ile Asp Thr Tyr Arg Ala Leu Glu Glu Cys Val Asp 
145                 150                 155                 160 


Glu Gly Leu Ile Lys Ser Ile Gly Val Ser Asn Phe Gln Gly Ser Leu 
                165                 170                 175     


Ile Gln Asp Leu Leu Arg Gly Cys Arg Ile Lys Pro Val Ala Leu Gln 
            180                 185                 190         


Ile Glu His His Pro Tyr Leu Thr Gln Glu His Leu Val Glu Phe Cys 
        195                 200                 205             


Lys Leu His Asp Ile Gln Val Val Ala Tyr Ser Ser Phe Gly Pro Gln 
    210                 215                 220                 


Ser Phe Ile Glu Met Asp Leu Gln Leu Ala Lys Thr Thr Pro Thr Leu 
225                 230                 235                 240 


Phe Glu Asn Asp Val Ile Lys Lys Val Ser Gln Asn His Pro Gly Ser 
                245                 250                 255     


Thr Thr Ser Gln Val Leu Leu Arg Trp Ala Thr Gln Arg Gly Ile Ala 
            260                 265                 270         


Val Ile Pro Lys Ser Ser Lys Lys Glu Arg Leu Leu Gly Asn Leu Glu 
        275                 280                 285             


Ile Glu Lys Lys Phe Thr Leu Thr Glu Gln Glu Leu Lys Asp Ile Ser 
    290                 295                 300                 


Ala Leu Asn Ala Asn Ile Arg Phe Asn Asp Pro Trp Thr Trp Leu Asp 
305                 310                 315                 320 


Gly Lys Phe Pro Thr Phe Ala 
                325         


<210>  10
<211>  984
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  10
atgtcttcac tggttactct taataacggt ctgaaaatgc ccctagtcgg cttagggtgc       60

tggaaaattg acaaaaaagt ctgtgcgaat caaatttatg aagctatcaa attaggctac      120

cgtttattcg atggtgcttg cgactacggc aacgaaaagg aagttggtga aggtatcagg      180

aaagccatct ccgaaggtct tgtttctaga aaggatatat ttgttgtttc aaagttatgg      240

aacaattttc accatcctga tcatgtaaaa ttagctttaa agaagacctt aagcgatatg      300

ggacttgatt atttagacct gtattatatt cacttcccaa tcgccttcaa atatgttcca      360

tttgaagaga aataccctcc aggattctat acgggcgcag atgacgagaa gaaaggtcac      420

atcaccgaag cacatgtacc aatcatagat acgtaccggg ctctggaaga atgtgttgat      480

gaaggcttga ttaagtctat tggtgtttcc aactttcagg gaagcttgat tcaagattta      540

ttacgtggtt gtagaatcaa gcccgtggct ttgcaaattg aacaccatcc ttatttgact      600

caagaacacc tagttgagtt ttgtaaatta cacgatatcc aagtagttgc ttactcctcc      660

ttcggtcctc aatcattcat tgagatggac ttacagttgg caaaaaccac gccaactctg      720

ttcgagaatg atgtaatcaa gaaggtctca caaaaccatc caggcagtac cacttcccaa      780

gtattgctta gatgggcaac tcagagaggc attgccgtca ttccaaaatc ttccaagaag      840

gaaaggttac ttggcaacct agaaatcgaa aaaaagttca ctttaacgga gcaagaattg      900

aaggatattt ctgcactaaa tgccaacatc agatttaatg atccatggac ctggttggat      960

ggtaaattcc ccacttttgc ctga                                             984


<210>  11
<211>  344
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  11

Met Ser Asn Thr Val Leu Val Ser Gly Ala Ser Gly Phe Ile Ala Leu 
1               5                   10                  15      


His Ile Leu Ser Gln Leu Leu Lys Gln Asp Tyr Lys Val Ile Gly Thr 
            20                  25                  30          


Val Arg Ser His Glu Lys Glu Ala Lys Leu Leu Arg Gln Phe Gln His 
        35                  40                  45              


Asn Pro Asn Leu Thr Leu Glu Ile Val Pro Asp Ile Ser His Pro Asn 
    50                  55                  60                  


Ala Phe Asp Lys Val Leu Gln Lys Arg Gly Arg Glu Ile Arg Tyr Val 
65                  70                  75                  80  


Leu His Thr Ala Ser Pro Phe His Tyr Asp Thr Thr Glu Tyr Glu Lys 
                85                  90                  95      


Asp Leu Leu Ile Pro Ala Leu Glu Gly Thr Lys Asn Ile Leu Asn Ser 
            100                 105                 110         


Ile Lys Lys Tyr Ala Ala Asp Thr Val Glu Arg Val Val Val Thr Ser 
        115                 120                 125             


Ser Cys Thr Ala Ile Ile Thr Leu Ala Lys Met Asp Asp Pro Ser Val 
    130                 135                 140                 


Val Phe Thr Glu Glu Ser Trp Asn Glu Ala Thr Trp Glu Ser Cys Gln 
145                 150                 155                 160 


Ile Asp Gly Ile Asn Ala Tyr Phe Ala Ser Lys Lys Phe Ala Glu Lys 
                165                 170                 175     


Ala Ala Trp Glu Phe Thr Lys Glu Asn Glu Asp His Ile Lys Phe Lys 
            180                 185                 190         


Leu Thr Thr Val Asn Pro Ser Leu Leu Phe Gly Pro Gln Leu Phe Asp 
        195                 200                 205             


Glu Asp Val His Gly His Leu Asn Thr Ser Cys Glu Met Ile Asn Gly 
    210                 215                 220                 


Leu Ile His Thr Pro Val Asn Ala Ser Val Pro Asp Phe His Ser Ile 
225                 230                 235                 240 


Phe Ile Asp Val Arg Asp Val Ala Leu Ala His Leu Tyr Ala Phe Gln 
                245                 250                 255     


Lys Glu Asn Thr Ala Gly Lys Arg Leu Val Val Thr Asn Gly Lys Phe 
            260                 265                 270         


Gly Asn Gln Asp Ile Leu Asp Ile Leu Asn Glu Asp Phe Pro Gln Leu 
        275                 280                 285             


Arg Gly Leu Ile Pro Leu Gly Lys Pro Gly Thr Gly Asp Gln Val Ile 
    290                 295                 300                 


Asp Arg Gly Ser Thr Thr Asp Asn Ser Ala Thr Arg Lys Ile Leu Gly 
305                 310                 315                 320 


Phe Glu Phe Arg Ser Leu His Glu Ser Val His Asp Thr Ala Ala Gln 
                325                 330                 335     


Ile Leu Lys Lys Gln Asn Arg Leu 
            340                 


<210>  12
<211>  1035
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  12
atgtctaata cagttctagt ttctggcgct tcaggtttta ttgccttgca tatcctgtca       60

caattgttaa aacaagatta taaggttatt ggaactgtga gatcccatga aaaagaagca      120

aaattgctaa gacaatttca acataaccct aatttaactt tagaaattgt tccggacatt      180

tctcatccaa atgctttcga taaggttctg cagaaacgtg gacgtgagat taggtatgtt      240

ctacacacgg cctctccttt tcattatgat actaccgaat atgaaaaaga cttattgatt      300

cccgcgttag aaggtacaaa aaacatccta aattctatca agaaatatgc agcagacact      360

gtagagcgtg ttgttgtgac ttcttcttgt actgctatta taacccttgc aaagatggac      420

gatcccagtg tggtttttac agaagagagt tggaacgaag caacctggga aagctgtcaa      480

attgatggga taaatgctta ctttgcatcc aagaagtttg ctgaaaaggc tgcctgggag      540

ttcacaaaag agaatgaaga tcacatcaaa ttcaaactaa caacagtcaa cccttctctt      600

ctttttggtc ctcaactttt cgatgaagat gtgcatggcc atttgaatac ttcttgcgaa      660

atgatcaatg gcctaattca taccccagta aatgccagtg ttcctgattt tcattccatt      720

tttattgatg taagggatgt ggccctagct catctgtatg ctttccagaa ggaaaatacc      780

gcgggtaaaa gattagtggt aactaacggt aaatttggaa accaagatat cctggatatt      840

ttgaacgaag attttccaca attaagaggt ctcattcctt tgggtaagcc tggcacaggt      900

gatcaagtca ttgaccgcgg ttcaactaca gataatagtg caacgaggaa aatacttggc      960

tttgagttca gaagtttaca cgaaagtgtc catgatactg ctgcccaaat tttgaagaag     1020

cagaacagat tatga                                                      1035


<210>  13
<211>  376
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  13

Met Gln Val Ala Ile Pro Glu Thr Met Lys Ala Val Val Ile Glu Asp 
1               5                   10                  15      


Gly Lys Ala Val Val Lys Glu Gly Ile Pro Ile Pro Glu Leu Glu Glu 
            20                  25                  30          


Gly Phe Val Leu Ile Lys Thr Leu Ala Val Ala Gly Asn Pro Thr Asp 
        35                  40                  45              


Trp Ala His Ile Asp Tyr Lys Ile Gly Pro Gln Gly Ser Ile Leu Gly 
    50                  55                  60                  


Cys Asp Ala Ala Gly Gln Ile Val Lys Leu Gly Pro Ala Val Asn Pro 
65                  70                  75                  80  


Lys Asp Phe Ser Ile Gly Asp Tyr Ile Tyr Gly Phe Ile His Gly Ser 
                85                  90                  95      


Ser Val Arg Phe Pro Ser Asn Gly Ala Phe Ala Glu Tyr Ser Ala Ile 
            100                 105                 110         


Ser Thr Val Val Ala Tyr Lys Ser Pro Asn Glu Leu Lys Phe Leu Gly 
        115                 120                 125             


Glu Asp Val Leu Pro Ala Gly Pro Val Arg Ser Leu Glu Gly Val Ala 
    130                 135                 140                 


Thr Ile Pro Val Ser Leu Thr Thr Ala Gly Leu Val Leu Thr Tyr Asn 
145                 150                 155                 160 


Leu Gly Leu Asp Leu Lys Trp Glu Pro Ser Thr Pro Gln Arg Lys Gly 
                165                 170                 175     


Pro Ile Leu Leu Trp Gly Gly Ala Thr Ala Val Gly Gln Ser Leu Ile 
            180                 185                 190         


Gln Leu Ala Asn Lys Leu Asn Gly Phe Thr Lys Ile Ile Val Val Ala 
        195                 200                 205             


Ser Arg Lys His Glu Lys Leu Leu Lys Glu Tyr Gly Ala Asp Glu Leu 
    210                 215                 220                 


Phe Asp Tyr His Asp Ile Asp Val Val Glu Gln Ile Lys His Lys Tyr 
225                 230                 235                 240 


Asn Asn Ile Ser Tyr Leu Val Asp Cys Val Ala Asn Gln Asp Thr Leu 
                245                 250                 255     


Gln Gln Val Tyr Lys Cys Ala Ala Asp Lys Gln Asp Ala Thr Ile Val 
            260                 265                 270         


Glu Leu Lys Asn Leu Thr Glu Glu Asn Val Lys Lys Glu Asn Arg Arg 
        275                 280                 285             


Gln Asn Val Thr Ile Asp Ile Ile Arg Leu Tyr Ser Ile Gly Gly His 
    290                 295                 300                 


Glu Val Pro Phe Gly Asn Ile Thr Leu Pro Ala Asp Ser Glu Ala Arg 
305                 310                 315                 320 


Lys Ala Ala Ile Lys Phe Ile Lys Phe Ile Asn Pro Lys Ile Asn Asp 
                325                 330                 335     


Gly Gln Ile Arg His Ile Pro Val Arg Val Tyr Lys Asn Gly Leu Cys 
            340                 345                 350         


Asp Val Pro His Ile Leu Lys Asp Ile Lys Tyr Gly Lys Asn Ser Gly 
        355                 360                 365             


Glu Lys Leu Val Ala Val Leu Asn 
    370                 375     


<210>  14
<211>  1131
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  14
atgcaagttg caattccaga aaccatgaag gctgtcgtca ttgaagacgg taaagcggtt       60

gttaaagagg gcattcccat tcctgaattg gaagaaggat tcgtattgat taagacactc      120

gctgttgctg gtaaccccac tgattgggca cacattgact acaagatcgg gcctcaagga      180

tctattctgg gatgtgatgc tgctggccaa attgtcaaat tgggcccagc tgtcaatcct      240

aaagactttt ctatcggtga ttatatttat gggttcattc acggatcttc cgtaaggttt      300

ccttccaatg gtgcttttgc tgaatattct gctatttcaa ctgtggttgc ctacaaatca      360

cccaatgaac tcaaattttt gggtgaggat gttctacctg ccggccctgt caggtctttg      420

gaaggtgtag ccactatccc agtgtcactg accacagccg gcttggtgtt gacctataac      480

ttgggcttgg acctgaagtg ggagccatca accccacaaa gaaaaggccc catcttatta      540

tggggcggtg caactgcagt aggtcagtcg ctcatccaat tagccaataa attgaatggc      600

ttcaccaaga tcattgttgt ggcttctcgg aagcacgaaa aacttttgaa agaatatggt      660

gctgatgaat tatttgatta tcatgatatt gacgtggtag aacaaattaa acacaagtac      720

aacaatatct cgtatttagt cgactgtgtc gcgaatcaag atacgcttca acaagtgtac      780

aaatgtgcgg ccgataaaca ggatgctaca attgttgaat taaaaaattt gacagaagaa      840

aacgtcaaaa aagagaacag gagacaaaac gttactattg acataataag gctatattca      900

ataggtggcc atgaagtacc atttggaaac attactttac cagccgactc agaagctagg      960

aaagctgcaa taaaatttat caaattcatc aatccaaaga ttaatgatgg acaaattcgc     1020

catattccag taagggtcta taagaacggg ctttgtgatg ttcctcatat cctaaaagac     1080

atcaaatatg gtaagaactc tggtgaaaaa ctcgttgccg tattaaacta g              1131


<210>  15
<211>  347
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  15

Met Thr Thr Asp Thr Thr Val Phe Val Ser Gly Ala Thr Gly Phe Ile 
1               5                   10                  15      


Ala Leu His Ile Met Asn Asp Leu Leu Lys Ala Gly Tyr Thr Val Ile 
            20                  25                  30          


Gly Ser Gly Arg Ser Gln Glu Lys Asn Asp Gly Leu Leu Lys Lys Phe 
        35                  40                  45              


Asn Asn Asn Pro Lys Leu Ser Met Glu Ile Val Glu Asp Ile Ala Ala 
    50                  55                  60                  


Pro Asn Ala Phe Asp Glu Val Phe Lys Lys His Gly Lys Glu Ile Lys 
65                  70                  75                  80  


Ile Val Leu His Thr Ala Ser Pro Phe His Phe Glu Thr Thr Asn Phe 
                85                  90                  95      


Glu Lys Asp Leu Leu Thr Pro Ala Val Asn Gly Thr Lys Ser Ile Leu 
            100                 105                 110         


Glu Ala Ile Lys Lys Tyr Ala Ala Asp Thr Val Glu Lys Val Ile Val 
        115                 120                 125             


Thr Ser Ser Thr Ala Ala Leu Val Thr Pro Thr Asp Met Asn Lys Gly 
    130                 135                 140                 


Asp Leu Val Ile Thr Glu Glu Ser Trp Asn Lys Asp Thr Trp Asp Ser 
145                 150                 155                 160 


Cys Gln Ala Asn Ala Val Ala Ala Tyr Cys Gly Ser Lys Lys Phe Ala 
                165                 170                 175     


Glu Lys Thr Ala Trp Glu Phe Leu Lys Glu Asn Lys Ser Ser Val Lys 
            180                 185                 190         


Phe Thr Leu Ser Thr Ile Asn Pro Gly Phe Val Phe Gly Pro Gln Met 
        195                 200                 205             


Phe Ala Asp Ser Leu Lys His Gly Ile Asn Thr Ser Ser Gly Ile Val 
    210                 215                 220                 


Ser Glu Leu Ile His Ser Lys Val Gly Gly Glu Phe Tyr Asn Tyr Cys 
225                 230                 235                 240 


Gly Pro Phe Ile Asp Val Arg Asp Val Ser Lys Ala His Leu Val Ala 
                245                 250                 255     


Ile Glu Lys Pro Glu Cys Thr Gly Gln Arg Leu Val Leu Ser Glu Gly 
            260                 265                 270         


Leu Phe Cys Cys Gln Glu Ile Val Asp Ile Leu Asn Glu Glu Phe Pro 
        275                 280                 285             


Gln Leu Lys Gly Lys Ile Ala Thr Gly Glu Pro Ala Thr Gly Pro Ser 
    290                 295                 300                 


Phe Leu Glu Lys Asn Ser Cys Lys Phe Asp Asn Ser Lys Thr Lys Lys 
305                 310                 315                 320 


Leu Leu Gly Phe Gln Phe Tyr Asn Leu Lys Asp Cys Ile Val Asp Thr 
                325                 330                 335     


Ala Ala Gln Met Leu Glu Val Gln Asn Glu Ala 
            340                 345         


<210>  16
<211>  1044
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  16
atgactactg ataccactgt tttcgtttct ggcgcaaccg gtttcattgc tctacacatt       60

atgaacgatc tgttgaaagc tggctataca gtcatcggct caggtagatc tcaagaaaaa      120

aatgatggct tgctcaaaaa atttaataac aatcccaaac tatcgatgga aattgtggaa      180

gatattgctg ctccaaacgc ctttgatgaa gttttcaaaa aacatggtaa ggaaattaag      240

attgtgctac acactgcctc cccattccat tttgaaacta ccaattttga aaaggattta      300

ctaacccctg cagtgaacgg tacaaaatct atcttggaag cgattaaaaa atatgctgca      360

gacactgttg aaaaagttat tgttacttcg tctactgctg ctctggtgac acctacagac      420

atgaacaaag gagatttggt gatcacggag gagagttgga ataaggatac atgggacagt      480

tgtcaagcca acgccgttgc cgcatattgt ggctcgaaaa agtttgctga aaaaactgct      540

tgggaatttc ttaaagaaaa caagtctagt gtcaaattca cactatccac tatcaatccg      600

ggattcgttt ttggtcctca aatgtttgca gattcgctaa aacatggcat aaatacctcc      660

tcagggatcg tatctgagtt aattcattcc aaggtaggtg gagaatttta taattactgt      720

ggcccattta ttgacgtgcg tgacgtttct aaagcccacc tagttgcaat tgaaaaacca      780

gaatgtaccg gccaaagatt agtattgagt gaaggtttat tctgctgtca agaaatcgtt      840

gacatcttga acgaggaatt ccctcaatta aagggcaaga tagctacagg tgaacctgcg      900

accggtccaa gctttttaga aaaaaactct tgcaagtttg acaattctaa gacaaaaaaa      960

ctactgggat tccagtttta caatttaaag gattgcatag ttgacaccgc ggcgcaaatg     1020

ttagaagttc aaaatgaagc ctaa                                            1044


<210>  17
<211>  348
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  17

Met Thr Thr Glu Lys Thr Val Val Phe Val Ser Gly Ala Thr Gly Phe 
1               5                   10                  15      


Ile Ala Leu His Val Val Asp Asp Leu Leu Lys Thr Gly Tyr Lys Val 
            20                  25                  30          


Ile Gly Ser Gly Arg Ser Gln Glu Lys Asn Asp Gly Leu Leu Lys Lys 
        35                  40                  45              


Phe Lys Ser Asn Pro Asn Leu Ser Met Glu Ile Val Glu Asp Ile Ala 
    50                  55                  60                  


Ala Pro Asn Ala Phe Asp Lys Val Phe Gln Lys His Gly Lys Glu Ile 
65                  70                  75                  80  


Lys Val Val Leu His Ile Ala Ser Pro Val His Phe Asn Thr Thr Asp 
                85                  90                  95      


Phe Glu Lys Asp Leu Leu Ile Pro Ala Val Asn Gly Thr Lys Ser Ile 
            100                 105                 110         


Leu Glu Ala Ile Lys Asn Tyr Ala Ala Asp Thr Val Glu Lys Val Val 
        115                 120                 125             


Ile Thr Ser Ser Val Ala Ala Leu Ala Ser Pro Gly Asp Met Lys Asp 
    130                 135                 140                 


Thr Ser Phe Val Val Asn Glu Glu Ser Trp Asn Lys Asp Thr Trp Glu 
145                 150                 155                 160 


Ser Cys Gln Ala Asn Ala Val Ser Ala Tyr Cys Gly Ser Lys Lys Phe 
                165                 170                 175     


Ala Glu Lys Thr Ala Trp Asp Phe Leu Glu Glu Asn Gln Ser Ser Ile 
            180                 185                 190         


Lys Phe Thr Leu Ser Thr Ile Asn Pro Gly Phe Val Phe Gly Pro Gln 
        195                 200                 205             


Leu Phe Ala Asp Ser Leu Arg Asn Gly Ile Asn Ser Ser Ser Ala Ile 
    210                 215                 220                 


Ile Ala Asn Leu Val Ser Tyr Lys Leu Gly Asp Asn Phe Tyr Asn Tyr 
225                 230                 235                 240 


Ser Gly Pro Phe Ile Asp Val Arg Asp Val Ser Lys Ala His Leu Leu 
                245                 250                 255     


Ala Phe Glu Lys Pro Glu Cys Ala Gly Gln Arg Leu Phe Leu Cys Glu 
            260                 265                 270         


Asp Met Phe Cys Ser Gln Glu Ala Leu Asp Ile Leu Asn Glu Glu Phe 
        275                 280                 285             


Pro Gln Leu Lys Gly Lys Ile Ala Thr Gly Glu Pro Gly Ser Gly Ser 
    290                 295                 300                 


Thr Phe Leu Thr Lys Asn Cys Cys Lys Cys Asp Asn Arg Lys Thr Lys 
305                 310                 315                 320 


Asn Leu Leu Gly Phe Gln Phe Asn Lys Phe Arg Asp Cys Ile Val Asp 
                325                 330                 335     


Thr Ala Ser Gln Leu Leu Glu Val Gln Ser Lys Ser 
            340                 345             


<210>  18
<211>  1047
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  18
atgactactg aaaaaaccgt tgtttttgtt tctggtgcta ctggtttcat tgctctacac       60

gtagtggacg atttattaaa aactggttac aaggtcatcg gttcgggtag gtcccaagaa      120

aagaatgatg gattgctgaa aaaatttaag agcaatccca acctttcaat ggagattgtc      180

gaagacattg ctgctccaaa cgcttttgac aaagtttttc aaaagcacgg caaagagatc      240

aaggttgtct tgcacatagc ttctccggtt cacttcaaca ccactgattt cgaaaaggat      300

ctgctaattc ctgctgtgaa tggtaccaag tccattctag aagcaatcaa aaattatgcc      360

gcagacacag tcgaaaaagt cgttattact tcttctgttg ctgcccttgc atctcccgga      420

gatatgaagg acactagttt cgttgtcaat gaggaaagtt ggaacaaaga tacttgggaa      480

agttgtcaag ctaacgcggt ttccgcatac tgtggttcca agaaatttgc tgaaaaaact      540

gcttgggatt ttctcgagga aaaccaatca agcatcaaat ttacgctatc aaccatcaac      600

ccaggatttg tttttggccc tcagctattt gccgactctc ttagaaatgg aataaatagc      660

tcttcagcca ttattgccaa tttggttagt tataaattag gcgacaattt ttataattac      720

agtggtcctt ttattgacgt tcgcgatgtt tcaaaagctc atttacttgc atttgagaaa      780

cccgaatgcg ctggccaaag actattctta tgtgaagata tgttttgctc tcaagaagcg      840

ctggatatct tgaatgagga atttccacag ttaaaaggca agatagcaac tggcgaacct      900

ggtagcggct caaccttttt gacaaaaaac tgctgcaagt gcgacaaccg caaaaccaaa      960

aatttattag gattccaatt taataagttc agagattgca ttgtcgatac tgcctcgcaa     1020

ttactagaag ttcaaagtaa aagctaa                                         1047


<210>  19
<211>  368
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  19

Met Lys Ala Val Val Ile Glu Asp Gly Lys Ala Val Val Lys Glu Gly 
1               5                   10                  15      


Val Pro Ile Pro Glu Leu Glu Glu Gly Phe Val Leu Ile Lys Thr Leu 
            20                  25                  30          


Ala Val Ala Gly Asn Pro Thr Asp Trp Ala His Ile Asp Tyr Lys Val 
        35                  40                  45              


Gly Pro Gln Gly Ser Ile Leu Gly Cys Asp Ala Ala Gly Gln Ile Val 
    50                  55                  60                  


Lys Leu Gly Pro Ala Val Asp Pro Lys Asp Phe Ser Ile Gly Asp Tyr 
65                  70                  75                  80  


Ile Tyr Gly Phe Ile His Gly Ser Ser Val Arg Phe Pro Ser Asn Gly 
                85                  90                  95      


Ala Phe Ala Glu Tyr Ser Ala Ile Ser Thr Val Val Ala Tyr Lys Ser 
            100                 105                 110         


Pro Asn Glu Leu Lys Phe Leu Gly Glu Asp Val Leu Pro Ala Gly Pro 
        115                 120                 125             


Val Arg Ser Leu Glu Gly Ala Ala Thr Ile Pro Val Ser Leu Thr Thr 
    130                 135                 140                 


Ala Gly Leu Val Leu Thr Tyr Asn Leu Gly Leu Asn Leu Lys Trp Glu 
145                 150                 155                 160 


Pro Ser Thr Pro Gln Arg Asn Gly Pro Ile Leu Leu Trp Gly Gly Ala 
                165                 170                 175     


Thr Ala Val Gly Gln Ser Leu Ile Gln Leu Ala Asn Lys Leu Asn Gly 
            180                 185                 190         


Phe Thr Lys Ile Ile Val Val Ala Ser Arg Lys His Glu Lys Leu Leu 
        195                 200                 205             


Lys Glu Tyr Gly Ala Asp Gln Leu Phe Asp Tyr His Asp Ile Asp Val 
    210                 215                 220                 


Val Glu Gln Ile Lys His Lys Tyr Asn Asn Ile Ser Tyr Leu Val Asp 
225                 230                 235                 240 


Cys Val Ala Asn Gln Asn Thr Leu Gln Gln Val Tyr Lys Cys Ala Ala 
                245                 250                 255     


Asp Lys Gln Asp Ala Thr Val Val Glu Leu Thr Asn Leu Thr Glu Glu 
            260                 265                 270         


Asn Val Lys Lys Glu Asn Arg Arg Gln Asn Val Thr Ile Asp Arg Thr 
        275                 280                 285             


Arg Leu Tyr Ser Ile Gly Gly His Glu Val Pro Phe Gly Gly Ile Thr 
    290                 295                 300                 


Phe Pro Ala Asp Pro Glu Ala Arg Arg Ala Ala Thr Glu Phe Val Lys 
305                 310                 315                 320 


Phe Ile Asn Pro Lys Ile Ser Asp Gly Gln Ile His His Ile Pro Ala 
                325                 330                 335     


Arg Val Tyr Lys Asn Gly Leu Tyr Asp Val Pro Arg Ile Leu Glu Asp 
            340                 345                 350         


Ile Lys Ile Gly Lys Asn Ser Gly Glu Lys Leu Val Ala Val Leu Asn 
        355                 360                 365             


<210>  20
<211>  1107
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  20
atgaaggctg tcgtcattga agacggtaaa gcggttgtca aagagggcgt tcccattcct       60

gaattggaag aaggattcgt attgattaag acactcgctg ttgctggtaa cccgactgat      120

tgggcacaca ttgactacaa ggtcgggcct caaggatcta ttctgggatg tgacgctgcc      180

ggccaaattg tcaaattggg cccagccgtc gatcctaaag acttttctat tggtgattat      240

atttatgggt tcattcacgg atcttccgta aggtttcctt ccaatggtgc ttttgctgaa      300

tattctgcta tttcaactgt ggttgcctac aaatcaccca atgaactcaa atttttgggt      360

gaagatgttc tacctgccgg ccctgtcagg tctttggaag gggcagccac tatcccagtg      420

tcactgacca cagctggctt ggtgttgacc tataacttgg gcttgaacct gaagtgggag      480

ccatcaaccc cacaaagaaa cggccccatc ttattatggg gcggtgcaac tgcagtaggt      540

cagtcgctca tccaattagc caataaattg aatggcttca ccaagatcat tgttgtggct      600

tctcggaaac acgaaaaact gttgaaagaa tatggtgctg atcaactatt tgattaccat      660

gatattgacg tggtagaaca aattaaacac aagtacaaca atatctcgta tttagtcgac      720

tgtgtcgcga atcaaaatac gcttcaacaa gtgtacaaat gtgcggccga taaacaggat      780

gctaccgttg tcgaattaac taatttgaca gaagaaaacg tcaaaaagga gaataggagg      840

caaaatgtca ctattgacag aacaagactg tattcaatag gcggccatga agtaccattt      900

ggtggcatta ctttccctgc tgacccagaa gccaggagag ctgccaccga attcgtcaag      960

ttcatcaatc caaagattag tgatgggcaa attcaccata ttccagcaag ggtctataag     1020

aacgggcttt acgatgttcc tcgtatcctg gaagacatta aaatcggtaa gaactctggt     1080

gaaaaactag ttgccgtatt aaactag                                         1107


<210>  21
<211>  345
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  21

Met Ser Val Ala Asp Leu Lys Asn Asn Ile His Lys Leu Asp Thr Gly 
1               5                   10                  15      


Tyr Gly Leu Met Ser Leu Thr Trp Arg Ala Glu Pro Ile Pro Gln Ser 
            20                  25                  30          


Gln Ala Phe Glu Ala Met His Arg Val Val Glu Leu Ser Arg Glu Arg 
        35                  40                  45              


Gly His Lys Ala Phe Phe Asn Val Gly Glu Phe Tyr Gly Pro Asp Phe 
    50                  55                  60                  


Ile Asn Leu Ser Tyr Val His Asp Phe Phe Ala Lys Tyr Pro Asp Leu 
65                  70                  75                  80  


Arg Lys Asp Val Val Ile Ser Cys Lys Gly Gly Ala Asp Asn Ala Thr 
                85                  90                  95      


Leu Thr Pro Arg Gly Ser His Asp Asp Val Val Gln Ser Val Lys Asn 
            100                 105                 110         


Ser Val Ser Ala Ile Gly Gly Tyr Ile Asp Ile Phe Glu Val Ala Arg 
        115                 120                 125             


Ile Asp Thr Ser Leu Cys Thr Lys Gly Glu Val Tyr Pro Tyr Glu Ser 
    130                 135                 140                 


Phe Glu Ala Leu Ala Glu Met Ile Ser Glu Gly Val Ile Gly Gly Ile 
145                 150                 155                 160 


Ser Leu Ser Glu Val Asn Glu Glu Gln Ile Arg Ala Ile His Lys Asp 
                165                 170                 175     


Trp Gly Lys Phe Leu Thr Cys Val Glu Val Glu Leu Ser Leu Phe Ser 
            180                 185                 190         


Asn Asp Ile Leu His Asn Gly Ile Ala Lys Thr Cys Ala Glu Leu Gly 
        195                 200                 205             


Leu Ser Ile Ile Cys Tyr Ser Pro Leu Gly Arg Gly Leu Leu Thr Gly 
    210                 215                 220                 


Gln Leu Lys Ser Asn Ala Asp Ile Pro Glu Gly Asp Phe Arg Lys Ser 
225                 230                 235                 240 


Leu Lys Arg Phe Ser Asp Glu Ser Leu Lys Lys Asn Leu Thr Leu Val 
                245                 250                 255     


Arg Phe Leu Gln Glu Glu Ile Val Asp Lys Arg Pro Gln Asn Asn Ser 
            260                 265                 270         


Ile Thr Leu Ala Gln Leu Ala Leu Gly Trp Val Lys His Trp Asn Lys 
        275                 280                 285             


Val Pro Glu Tyr Ser Gly Ala Lys Phe Ile Pro Ile Pro Ser Gly Ser 
    290                 295                 300                 


Ser Ile Ser Lys Val Asn Glu Asn Phe Asp Glu Gln Lys Thr Lys Leu 
305                 310                 315                 320 


Thr Asp Gln Glu Phe Asn Ala Ile Asn Lys Tyr Leu Thr Thr Phe His 
                325                 330                 335     


Thr Val Gly Asp Arg Tyr Glu Met Ala 
            340                 345 


<210>  22
<211>  1038
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  22
atgtctgtcg ccgatttgaa aaacaacatc cacaagttag atactggcta tggtttaatg       60

agtttgactt ggagagccga gcctatccct cagtcgcagg ctttcgaggc catgcacaga      120

gtggttgagt tatccagaga acgtgggcac aaggcctttt tcaacgttgg tgaattctat      180

ggtcccgatt ttattaattt gtcgtatgtt cacgacttct ttgcgaaata cccagatttg      240

agaaaggatg tggttatcag ttgtaaaggt ggtgcagaca atgctacctt aacccccaga      300

ggcagtcacg atgatgttgt acaaagcgta aagaattcag ttagtgctat tggtggctac      360

atcgacatct tcgaagtcgc aagaatcgac acttccctat gcacgaaagg agaggtctac      420

ccctacgaat cgttcgaagc gcttgctgag atgatctccg aaggcgttat tggcggtatt      480

tcattaagtg aagttaatga agagcaaatt agagctattc acaaggattg gggaaagttt      540

ttgacctgcg ttgaagtgga actttctttg ttcagtaatg acattttaca caacggaatt      600

gctaaaacat gtgctgaatt ggggttgtcc atcatctgct actccccact gggcagagga      660

ttgttgacag gtcaattgaa gtcaaacgct gatatccctg agggtgactt tagaaagtcg      720

ttaaagagat ttagcgacga gtctttgaaa aaaaacctga ccttggtcag gtttctacag      780

gaagaaatag tcgacaagcg cccacaaaac aactccatta ctcttgcaca actggctttg      840

ggatgggtta agcactggaa caaagttccg gaatacagtg gcgccaaatt tatcccaatt      900

ccaagtggct cttctatttc caaggttaat gaaaactttg atgaacagaa aaccaaactt      960

accgatcaag agttcaatgc cattaacaaa tatttgacta ctttccatac tgttggtgac     1020

agatacgaaa tggcgtaa                                                   1038


<210>  23
<211>  612
<212>  DNA
<213>  Coptis japonica

<400>  23
aagcttaaaa tgagaatgga agtcgtcttg gtcgttttct tgatgttcat tggtactatc       60

aactgcgaaa gattgatctt caatggtaga cctttgttgc acagagttac caaagaagaa      120

accgttatgt tgtaccacga attggaagtt gctgcttctg ctgatgaagt ttggtctgtt      180

gaaggttctc cagaattggg tttacatttg ccagatttgt tgccagctgg tatttttgcc      240

aagttcgaaa ttactggtga tggtggtgaa ggttccattt tggatatgac ttttccacca      300

ggtcaattcc cacatcatta cagagaaaag ttcgtctttt tcgaccacaa gaacagatac      360

aagttggtcg aacaaatcga tggtgatttc ttcgatttgg gtgttactta ctacatggac      420

accattagag ttgttgctac tggtccagat tcttgcgtta ttaagtctac tactgaatac      480

cacgtcaagc cagaatttgc taaaatcgtt aagccattga tcgataccgt tccattggct      540

attatgtctg aagctattgc caaggttgtc ttggaaaaca aacacaagtc atctgaatga      600

aagactccgc gg                                                          612


<210>  24
<211>  196
<212>  PRT
<213>  Coptis japonica

<400>  24

Met Arg Met Glu Val Val Leu Val Val Phe Leu Met Phe Ile Gly Thr 
1               5                   10                  15      


Ile Asn Cys Glu Arg Leu Ile Phe Asn Gly Arg Pro Leu Leu His Arg 
            20                  25                  30          


Val Thr Lys Glu Glu Thr Val Met Leu Tyr His Glu Leu Glu Val Ala 
        35                  40                  45              


Ala Ser Ala Asp Glu Val Trp Ser Val Glu Gly Ser Pro Glu Leu Gly 
    50                  55                  60                  


Leu His Leu Pro Asp Leu Leu Pro Ala Gly Ile Phe Ala Lys Phe Glu 
65                  70                  75                  80  


Ile Thr Gly Asp Gly Gly Glu Gly Ser Ile Leu Asp Met Thr Phe Pro 
                85                  90                  95      


Pro Gly Gln Phe Pro His His Tyr Arg Glu Lys Phe Val Phe Phe Asp 
            100                 105                 110         


His Lys Asn Arg Tyr Lys Leu Val Glu Gln Ile Asp Gly Asp Phe Phe 
        115                 120                 125             


Asp Leu Gly Val Thr Tyr Tyr Met Asp Thr Ile Arg Val Val Ala Thr 
    130                 135                 140                 


Gly Pro Asp Ser Cys Val Ile Lys Ser Thr Thr Glu Tyr His Val Lys 
145                 150                 155                 160 


Pro Glu Phe Ala Lys Ile Val Lys Pro Leu Ile Asp Thr Val Pro Leu 
                165                 170                 175     


Ala Ile Met Ser Glu Ala Ile Ala Lys Val Val Leu Glu Asn Lys His 
            180                 185                 190         


Lys Ser Ser Glu 
        195     


<210>  25
<211>  363
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  25

Met Ile Gly Ser Ala Ser Asp Ser Ser Ser Lys Leu Gly Arg Leu Arg 
1               5                   10                  15      


Phe Leu Ser Glu Thr Ala Ala Ile Lys Val Ser Pro Leu Ile Leu Gly 
            20                  25                  30          


Glu Val Ser Tyr Asp Gly Ala Arg Ser Asp Phe Leu Lys Ser Met Asn 
        35                  40                  45              


Lys Asn Arg Ala Phe Glu Leu Leu Asp Thr Phe Tyr Glu Ala Gly Gly 
    50                  55                  60                  


Asn Phe Ile Asp Ala Ala Asn Asn Cys Gln Asn Glu Gln Ser Glu Glu 
65                  70                  75                  80  


Trp Ile Gly Glu Trp Ile Gln Ser Arg Arg Leu Arg Asp Gln Ile Val 
                85                  90                  95      


Ile Ala Thr Lys Phe Ile Lys Ser Asp Lys Lys Tyr Lys Ala Gly Glu 
            100                 105                 110         


Ser Asn Thr Ala Asn Tyr Cys Gly Asn His Lys Arg Ser Leu His Val 
        115                 120                 125             


Ser Val Arg Asp Ser Leu Arg Lys Leu Gln Thr Asp Trp Ile Asp Ile 
    130                 135                 140                 


Leu Tyr Val His Trp Trp Asp Tyr Met Ser Ser Ile Glu Glu Phe Met 
145                 150                 155                 160 


Asp Ser Leu His Ile Leu Val Gln Gln Gly Lys Val Leu Tyr Leu Gly 
                165                 170                 175     


Val Ser Asp Thr Pro Ala Trp Val Val Ser Ala Ala Asn Tyr Tyr Ala 
            180                 185                 190         


Thr Ser Tyr Gly Lys Thr Pro Phe Ser Ile Tyr Gln Gly Lys Trp Asn 
        195                 200                 205             


Val Leu Asn Arg Asp Phe Glu Arg Asp Ile Ile Pro Met Ala Arg His 
    210                 215                 220                 


Phe Gly Met Ala Leu Ala Pro Trp Asp Val Met Gly Gly Gly Arg Phe 
225                 230                 235                 240 


Gln Ser Lys Lys Ala Met Glu Glu Arg Arg Lys Asn Gly Glu Gly Ile 
                245                 250                 255     


Arg Ser Phe Val Gly Ala Ser Glu Gln Thr Asp Ala Glu Ile Lys Ile 
            260                 265                 270         


Ser Glu Ala Leu Ala Lys Ile Ala Glu Glu His Gly Thr Glu Ser Val 
        275                 280                 285             


Thr Ala Ile Ala Ile Ala Tyr Val Arg Ser Lys Ala Lys Asn Phe Phe 
    290                 295                 300                 


Pro Ser Val Glu Gly Gly Lys Ile Glu Asp Leu Lys Glu Asn Ile Lys 
305                 310                 315                 320 


Ala Leu Ser Ile Asp Leu Thr Pro Asp Asn Ile Lys Tyr Leu Glu Ser 
                325                 330                 335     


Ile Val Pro Phe Asp Ile Gly Phe Pro Asn Asn Phe Ile Val Leu Asn 
            340                 345                 350         


Ser Leu Thr Gln Lys Tyr Gly Thr Asn Asn Val 
        355                 360             


<210>  26
<211>  1092
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  26
atgattgggt ccgcgtccga ctcatctagc aagttaggac gcctccgatt tctttctgaa       60

actgccgcta ttaaagtatc cccgttaatc ctaggagaag tctcatacga tggagcacgt      120

tcggattttc tcaaatcaat gaacaagaat cgagcttttg aattgcttga tactttttac      180

gaggcaggtg gaaatttcat tgatgccgca aacaactgcc aaaacgagca atcagaagaa      240

tggattggtg aatggataca gtccagaagg ttacgtgatc aaattgtcat tgcaaccaag      300

tttataaaaa gcgataaaaa gtataaagca ggtgaaagta acactgccaa ctactgtggt      360

aatcacaagc gtagtttaca tgtgagtgtg agggattctc tccgcaaatt gcaaactgat      420

tggattgata tactttacgt tcactggtgg gattatatga gttcaatcga agaatttatg      480

gatagtttgc atattctggt ccagcagggc aaggtcctct atttgggtgt atctgataca      540

cctgcttggg ttgtttctgc ggcaaactac tacgctacat cttatggtaa aactcccttt      600

agtatctacc aaggtaaatg gaacgtgttg aacagagatt ttgagcgtga tattattcca      660

atggctaggc atttcggtat ggccctcgcc ccatgggatg tcatgggagg tggaagattt      720

cagagtaaaa aagcaatgga ggaacggagg aagaatggag agggtattcg ttctttcgtt      780

ggcgcctccg aacaaacaga tgcagaaatc aagattagtg aagcattggc caagattgct      840

gaggaacatg gcactgagtc tgttactgct attgctattg cctatgttcg ctctaaggcg      900

aaaaattttt ttccgtcggt tgaaggagga aaaattgagg atctcaaaga gaacattaag      960

gctctcagta tcgatctaac gccagacaat ataaaatact tagaaagtat agttcctttt     1020

gacatcggat ttcctaataa ttttatcgtg ttaaattcct tgactcaaaa atatggtacg     1080

aataatgttt ag                                                         1092


<210>  27
<211>  329
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  27

Met Gly Ser Met Asn Lys Glu Gln Ala Phe Glu Leu Leu Asp Ala Phe 
1               5                   10                  15      


Tyr Glu Ala Gly Gly Asn Cys Ile Asp Thr Ala Asn Ser Tyr Gln Asn 
            20                  25                  30          


Glu Glu Ser Glu Ile Trp Ile Gly Glu Trp Met Lys Ser Arg Lys Leu 
        35                  40                  45              


Arg Asp Gln Ile Val Ile Ala Thr Lys Phe Thr Gly Asp Tyr Lys Lys 
    50                  55                  60                  


Tyr Glu Val Gly Gly Gly Lys Ser Ala Asn Tyr Cys Gly Asn His Lys 
65                  70                  75                  80  


His Ser Leu His Val Ser Val Arg Asp Ser Leu Arg Lys Leu Gln Thr 
                85                  90                  95      


Asp Trp Ile Asp Ile Leu Tyr Val His Trp Trp Asp Tyr Met Ser Ser 
            100                 105                 110         


Ile Glu Glu Val Met Asp Ser Leu His Ile Leu Val Gln Gln Gly Lys 
        115                 120                 125             


Val Leu Tyr Leu Gly Val Ser Asp Thr Pro Ala Trp Val Val Ser Ala 
    130                 135                 140                 


Ala Asn Tyr Tyr Ala Thr Ser His Gly Lys Thr Pro Phe Ser Ile Tyr 
145                 150                 155                 160 


Gln Gly Lys Trp Asn Val Leu Asn Arg Asp Phe Glu Arg Asp Ile Ile 
                165                 170                 175     


Pro Met Ala Arg His Phe Gly Met Ala Leu Ala Pro Trp Asp Val Met 
            180                 185                 190         


Gly Gly Gly Arg Phe Gln Ser Lys Lys Ala Met Glu Glu Arg Lys Lys 
        195                 200                 205             


Asn Gly Glu Gly Leu Arg Thr Val Ser Gly Thr Ser Lys Gln Thr Asp 
    210                 215                 220                 


Lys Glu Val Lys Ile Ser Glu Ala Leu Ala Lys Val Ala Glu Glu His 
225                 230                 235                 240 


Gly Thr Glu Ser Val Thr Ala Ile Ala Ile Ala Tyr Val Arg Ser Lys 
                245                 250                 255     


Ala Lys Asn Val Phe Pro Leu Val Gly Gly Arg Lys Ile Glu His Leu 
            260                 265                 270         


Lys Gln Asn Ile Glu Ala Leu Ser Ile Lys Leu Thr Pro Glu Gln Ile 
        275                 280                 285             


Glu Tyr Leu Glu Ser Ile Ile Pro Phe Asp Val Gly Phe Pro Thr Asn 
    290                 295                 300                 


Phe Ile Gly Asp Asp Pro Ala Val Thr Lys Lys Ala Ser Leu Leu Thr 
305                 310                 315                 320 


Ala Met Ser Ala Gln Ile Ser Phe Asp 
                325                 


<210>  28
<211>  990
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  28
atgggctcta tgaataagga acaggctttt gaacttcttg atgcttttta tgaagcagga       60

ggtaattgca ttgatactgc aaacagttac caaaatgaag agtcagagat ttggataggt      120

gaatggatga aatcaagaaa gttgcgtgac caaattgtaa ttgccaccaa gtttaccgga      180

gattataaga agtatgaagt aggtggcggt aaaagtgcca actattgtgg taatcacaag      240

catagtttac atgtgagtgt gagggattct ctccgcaaat tgcaaactga ttggattgat      300

atactttacg ttcactggtg ggattatatg agttcaatcg aagaagttat ggatagtttg      360

catattttag ttcagcaggg caaagtcctc tatttgggtg tgtctgatac acctgcttgg      420

gttgtttctg cggcaaacta ctacgccaca tctcatggga aaactccttt tagtatctat      480

caaggtaaat ggaatgtgtt gaacagggac tttgagcgcg atatcattcc aatggccaga      540

cattttggta tggctctagc cccatgggat gttatgggag gtggaagatt tcagagtaaa      600

aaagcaatgg aggaacggaa gaagaatgga gagggtctgc gtactgtttc gggtacttct      660

aaacagacgg ataaagaggt taagatcagt gaagcattgg ccaaggttgc tgaggaacat      720

ggcactgagt ctgttactgc tattgctatt gcctatgttc gctctaaggc gaaaaatgtt      780

ttcccattgg ttggtggaag gaaaattgaa cacctcaaac agaacattga ggctttaagt      840

atcaaactga caccagaaca gatagaatac ttagaaagta ttattccttt tgatgttggt      900

tttcctacta attttatcgg tgatgatccg gctgttacca agaaggcttc acttctcacg      960

gcaatgtctg cgcagatttc cttcgattaa                                       990


<210>  29
<211>  375
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  29

Met Leu Arg Thr Ser Thr Leu Phe Thr Arg Arg Val Gln Pro Ser Leu 
1               5                   10                  15      


Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys 
            20                  25                  30          


Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Lys Leu His Tyr 
        35                  40                  45              


Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn 
    50                  55                  60                  


Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly 
65                  70                  75                  80  


Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly 
                85                  90                  95      


Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val 
            100                 105                 110         


Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys 
        115                 120                 125             


Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu 
    130                 135                 140                 


Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp 
145                 150                 155                 160 


Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val 
                165                 170                 175     


Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu 
            180                 185                 190         


Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly 
        195                 200                 205             


Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg 
    210                 215                 220                 


Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys 
225                 230                 235                 240 


Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val 
                245                 250                 255     


Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn 
            260                 265                 270         


Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg 
        275                 280                 285             


Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val 
    290                 295                 300                 


Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly 
305                 310                 315                 320 


Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe 
                325                 330                 335     


Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu 
            340                 345                 350         


Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg 
        355                 360                 365             


Tyr Val Val Asp Thr Ser Lys 
    370                 375 


<210>  30
<211>  1128
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  30
atgttgagaa cgtcaacatt gttcaccagg cgtgtccaac caagcctatt ttctagaaac       60

attcttagat tgcaatccac agctgcaatc cctaagactc aaaaaggtgt catcttttat      120

gagaataagg ggaagctgca ttacaaagat atccctgtcc ccgagcctaa gccaaatgaa      180

attttaatca acgttaaata ttctggtgta tgtcacaccg atttacatgc ttggcacggc      240

gattggccat tacctgttaa actaccatta gtaggtggtc atgaaggtgc tggtgtagtt      300

gtcaaactag gttccaatgt caagggctgg aaagtcggtg atttagcagg tatcaaatgg      360

ctgaacggtt cttgtatgac atgcgaattc tgtgaatcag gtcatgaatc aaattgtcca      420

gatgctgatt tatctggtta cactcatgat ggttctttcc aacaatttgc gaccgctgat      480

gctattcaag ccgccaaaat tcaacagggt accgacttgg ccgaagtagc cccaatatta      540

tgtgctggtg ttactgtata taaagcacta aaagaggcag acttgaaagc tggtgactgg      600

gttgccatct ctggtgctgc aggtggcttg ggttccttgg ccgttcaata tgcaactgcg      660

atgggttaca gagttctagg tattgatgca ggtgaggaaa aggaaaaact tttcaagaaa      720

ttggggggtg aagtattcat cgactttact aaaacaaaga atatggtttc tgacattcaa      780

gaagctacca aaggtggccc tcatggtgtc attaacgttt ccgtttctga agccgctatt      840

tctctatcta cggaatatgt tagaccatgt ggtaccgtcg ttttggttgg tttgcccgct      900

aacgcctacg ttaaatcaga ggtattctct catgtggtga agtccatcaa tatcaagggt      960

tcttatgttg gtaacagagc tgatacgaga gaagccttag acttctttag cagaggtttg     1020

atcaaatcac caatcaaaat tgttggatta tctgaattac caaaggttta tgacttgatg     1080

gaaaagggca agattttggg tagatacgtc gtcgatacta gtaaataa                  1128


<210>  31
<211>  382
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  31

Met Ser Ser Val Thr Gly Phe Tyr Ile Pro Pro Ile Ser Phe Phe Gly 
1               5                   10                  15      


Glu Gly Ala Leu Glu Glu Thr Ala Asp Tyr Ile Lys Asn Lys Asp Tyr 
            20                  25                  30          


Lys Lys Ala Leu Ile Val Thr Asp Pro Gly Ile Ala Ala Ile Gly Leu 
        35                  40                  45              


Ser Gly Arg Val Gln Lys Met Leu Glu Glu Arg Asp Leu Asn Val Ala 
    50                  55                  60                  


Ile Tyr Asp Lys Thr Gln Pro Asn Pro Asn Ile Ala Asn Val Thr Ala 
65                  70                  75                  80  


Gly Leu Lys Val Leu Lys Glu Gln Asn Ser Glu Ile Val Val Ser Ile 
                85                  90                  95      


Gly Gly Gly Ser Ala His Asp Asn Ala Lys Ala Ile Ala Leu Leu Ala 
            100                 105                 110         


Thr Asn Gly Gly Glu Ile Gly Asp Tyr Glu Gly Val Asn Gln Ser Lys 
        115                 120                 125             


Lys Ala Ala Leu Pro Leu Phe Ala Ile Asn Thr Thr Ala Gly Thr Ala 
    130                 135                 140                 


Ser Glu Met Thr Arg Phe Thr Ile Ile Ser Asn Glu Glu Lys Lys Ile 
145                 150                 155                 160 


Lys Met Ala Ile Ile Asp Asn Asn Val Thr Pro Ala Val Ala Val Asn 
                165                 170                 175     


Asp Pro Ser Thr Met Phe Gly Leu Pro Pro Ala Leu Thr Ala Ala Thr 
            180                 185                 190         


Gly Leu Asp Ala Leu Thr His Cys Ile Glu Ala Tyr Val Ser Thr Ala 
        195                 200                 205             


Ser Asn Pro Ile Thr Asp Ala Cys Ala Leu Lys Gly Ile Asp Leu Ile 
    210                 215                 220                 


Asn Glu Ser Leu Val Ala Ala Tyr Lys Asp Gly Lys Asp Lys Lys Ala 
225                 230                 235                 240 


Arg Thr Asp Met Cys Tyr Ala Glu Tyr Leu Ala Gly Met Ala Phe Asn 
                245                 250                 255     


Asn Ala Ser Leu Gly Tyr Val His Ala Leu Ala His Gln Leu Gly Gly 
            260                 265                 270         


Phe Tyr His Leu Pro His Gly Val Cys Asn Ala Val Leu Leu Pro His 
        275                 280                 285             


Val Gln Glu Ala Asn Met Gln Cys Pro Lys Ala Lys Lys Arg Leu Gly 
    290                 295                 300                 


Glu Ile Ala Leu His Phe Gly Ala Ser Gln Glu Asp Pro Glu Glu Thr 
305                 310                 315                 320 


Ile Lys Ala Leu His Val Leu Asn Arg Thr Met Asn Ile Pro Arg Asn 
                325                 330                 335     


Leu Lys Glu Leu Gly Val Lys Thr Glu Asp Phe Glu Ile Leu Ala Glu 
            340                 345                 350         


His Ala Met His Asp Ala Cys His Leu Thr Asn Pro Val Gln Phe Thr 
        355                 360                 365             


Lys Glu Gln Val Val Ala Ile Ile Lys Lys Ala Tyr Glu Tyr 
    370                 375                 380         


<210>  32
<211>  1149
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  32
atgtcttccg ttactgggtt ttacattcca ccaatctctt tctttggtga aggtgcttta       60

gaagaaaccg ctgattacat caaaaacaag gattacaaaa aggctttgat cgttactgat      120

cctggtattg cagctattgg tctctccggt agagtccaaa agatgttgga agaacgtgac      180

ttaaacgttg ctatctatga caaaactcaa ccaaacccaa atattgccaa tgtcacagct      240

ggtttgaagg ttttgaagga acaaaactct gaaattgttg tttccattgg tggtggttct      300

gctcacgaca atgctaaggc cattgcttta ttggctacta acggtgggga aatcggagac      360

tatgaaggtg tcaatcaatc taagaaggct gctttaccac tatttgccat caacactact      420

gctggtactg cttccgaaat gaccagattc actattatct ctaatgaaga aaagaaaatc      480

aagatggcta tcattgacaa caacgtcact ccagctgttg ctgtcaacga tccatctacc      540

atgtttggtt tgccacctgc tttgactgct gctactggtc tagatgcttt gactcactgt      600

atcgaagctt atgtttccac cgcctctaac ccaatcaccg atgcctgtgc tttgaagggt      660

attgatttga tcaatgaaag cttagtcgct gcatacaaag acggtaaaga caagaaggcc      720

agaactgaca tgtgttacgc tgaatacttg gcaggtatgg ctttcaacaa tgcttctcta      780

ggttatgttc atgcccttgc tcatcaactt ggtggtttct accacttgcc tcatggtgtt      840

tgtaacgctg tcttgttgcc tcatgttcaa gaggccaaca tgcaatgtcc aaaggccaag      900

aagagattag gtgaaattgc tttgcatttc ggtgcttctc aagaagatcc agaagaaacc      960

atcaaggctt tgcacgtttt aaacagaacc atgaacattc caagaaactt gaaagaatta     1020

ggtgttaaaa ccgaagattt tgaaattttg gctgaacacg ccatgcatga tgcctgccat     1080

ttgactaacc cagttcaatt caccaaagaa caagtggttg ccattatcaa gaaagcctat     1140

gaatattaa                                                             1149


<210>  33
<211>  500
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  33

Met Thr Lys Leu His Phe Asp Thr Ala Glu Pro Val Lys Ile Thr Leu 
1               5                   10                  15      


Pro Asn Gly Leu Thr Tyr Glu Gln Pro Thr Gly Leu Phe Ile Asn Asn 
            20                  25                  30          


Lys Phe Met Lys Ala Gln Asp Gly Lys Thr Tyr Pro Val Glu Asp Pro 
        35                  40                  45              


Ser Thr Glu Asn Thr Val Cys Glu Val Ser Ser Ala Thr Thr Glu Asp 
    50                  55                  60                  


Val Glu Tyr Ala Ile Glu Cys Ala Asp Arg Ala Phe His Asp Thr Glu 
65                  70                  75                  80  


Trp Ala Thr Gln Asp Pro Arg Glu Arg Gly Arg Leu Leu Ser Lys Leu 
                85                  90                  95      


Ala Asp Glu Leu Glu Ser Gln Ile Asp Leu Val Ser Ser Ile Glu Ala 
            100                 105                 110         


Leu Asp Asn Gly Lys Thr Leu Ala Leu Ala Arg Gly Asp Val Thr Ile 
        115                 120                 125             


Ala Ile Asn Cys Leu Arg Asp Ala Ala Ala Tyr Ala Asp Lys Val Asn 
    130                 135                 140                 


Gly Arg Thr Ile Asn Thr Gly Asp Gly Tyr Met Asn Phe Thr Thr Leu 
145                 150                 155                 160 


Glu Pro Ile Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Ile 
                165                 170                 175     


Met Met Leu Ala Trp Lys Ile Ala Pro Ala Leu Ala Met Gly Asn Val 
            180                 185                 190         


Cys Ile Leu Lys Pro Ala Ala Val Thr Pro Leu Asn Ala Leu Tyr Phe 
        195                 200                 205             


Ala Ser Leu Cys Lys Lys Val Gly Ile Pro Ala Gly Val Val Asn Ile 
    210                 215                 220                 


Val Pro Gly Pro Gly Arg Thr Val Gly Ala Ala Leu Thr Asn Asp Pro 
225                 230                 235                 240 


Arg Ile Arg Lys Leu Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Ser 
                245                 250                 255     


Val Ala Val Asp Ser Ser Glu Ser Asn Leu Lys Lys Ile Thr Leu Glu 
            260                 265                 270         


Leu Gly Gly Lys Ser Ala His Leu Val Phe Asp Asp Ala Asn Ile Lys 
        275                 280                 285             


Lys Thr Leu Pro Asn Leu Val Asn Gly Ile Phe Lys Asn Ala Gly Gln 
    290                 295                 300                 


Ile Cys Ser Ser Gly Ser Arg Ile Tyr Val Gln Glu Gly Ile Tyr Asp 
305                 310                 315                 320 


Glu Leu Leu Ala Ala Phe Lys Ala Tyr Leu Glu Thr Glu Ile Lys Val 
                325                 330                 335     


Gly Asn Pro Phe Asp Lys Ala Asn Phe Gln Gly Ala Ile Thr Asn Arg 
            340                 345                 350         


Gln Gln Phe Asp Thr Ile Met Asn Tyr Ile Asp Ile Gly Lys Lys Glu 
        355                 360                 365             


Gly Ala Lys Ile Leu Thr Gly Gly Glu Lys Val Gly Asp Lys Gly Tyr 
    370                 375                 380                 


Phe Ile Arg Pro Thr Val Phe Tyr Asp Val Asn Glu Asp Met Arg Ile 
385                 390                 395                 400 


Val Lys Glu Glu Ile Phe Gly Pro Val Val Thr Val Ala Lys Phe Lys 
                405                 410                 415     


Thr Leu Glu Glu Gly Val Glu Met Ala Asn Ser Ser Glu Phe Gly Leu 
            420                 425                 430         


Gly Ser Gly Ile Glu Thr Glu Ser Leu Ser Thr Gly Leu Lys Val Ala 
        435                 440                 445             


Lys Met Leu Lys Ala Gly Thr Val Trp Ile Asn Thr Tyr Asn Asp Phe 
    450                 455                 460                 


Asp Ser Arg Val Pro Phe Gly Gly Val Lys Gln Ser Gly Tyr Gly Arg 
465                 470                 475                 480 


Glu Met Gly Glu Glu Val Tyr His Ala Tyr Thr Glu Val Lys Ala Val 
                485                 490                 495     


Arg Ile Lys Leu 
            500 


<210>  34
<211>  1503
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  34
atgactaagc tacactttga cactgctgaa ccagtcaaga tcacacttcc aaatggtttg       60

acatacgagc aaccaaccgg tctattcatt aacaacaagt ttatgaaagc tcaagacggt      120

aagacctatc ccgtcgaaga tccttccact gaaaacaccg tttgtgaggt ctcttctgcc      180

accactgaag atgttgaata tgctatcgaa tgtgccgacc gtgctttcca cgacactgaa      240

tgggctaccc aagacccaag agaaagaggc cgtctactaa gtaagttggc tgacgaattg      300

gaaagccaaa ttgacttggt ttcttccatt gaagctttgg acaatggtaa aactttggcc      360

ttagcccgtg gggatgttac cattgcaatc aactgtctaa gagatgctgc tgcctatgcc      420

gacaaagtca acggtagaac aatcaacacc ggtgacggct acatgaactt caccacctta      480

gagccaatcg gtgtctgtgg tcaaattatt ccatggaact ttccaataat gatgttggct      540

tggaagatcg ccccagcatt ggccatgggt aacgtctgta tcttgaaacc cgctgctgtc      600

acacctttaa atgccctata ctttgcttct ttatgtaaga aggttggtat tccagctggt      660

gtcgtcaaca tcgttccagg tcctggtaga actgttggtg ctgctttgac caacgaccca      720

agaatcagaa agctggcttt taccggttct acagaagtcg gtaagagtgt tgctgtcgac      780

tcttctgaat ctaacttgaa gaaaatcact ttggaactag gtggtaagtc cgcccatttg      840

gtctttgacg atgctaacat taagaagact ttaccaaatc tagtaaacgg tattttcaag      900

aacgctggtc aaatttgttc ctctggttct agaatttacg ttcaagaagg tatttacgac      960

gaactattgg ctgctttcaa ggcttacttg gaaaccgaaa tcaaagttgg taatccattt     1020

gacaaggcta acttccaagg tgctatcact aaccgtcaac aattcgacac aattatgaac     1080

tacatcgata tcggtaagaa agaaggcgcc aagatcttaa ctggtggcga aaaagttggt     1140

gacaagggtt acttcatcag accaaccgtt ttctacgatg ttaatgaaga catgagaatt     1200

gttaaggaag aaatttttgg accagttgtc actgtcgcaa agttcaagac tttagaagaa     1260

ggtgtcgaaa tggctaacag ctctgaattc ggtctaggtt ctggtatcga aacagaatct     1320

ttgagcacag gtttgaaggt ggccaagatg ttgaaggccg gtaccgtctg gatcaacaca     1380

tacaacgatt ttgactccag agttccattc ggtggtgtta agcaatctgg ttacggtaga     1440

gaaatgggtg aagaagtcta ccatgcatac actgaagtaa aagctgtcag aattaagttg     1500

taa                                                                   1503


<210>  35
<211>  382
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  35

Met Arg Ala Leu Ala Tyr Phe Lys Lys Gly Asp Ile His Phe Thr Asn 
1               5                   10                  15      


Asp Ile Pro Arg Pro Glu Ile Gln Thr Asp Asp Glu Val Ile Ile Asp 
            20                  25                  30          


Val Ser Trp Cys Gly Ile Cys Gly Ser Asp Leu His Glu Tyr Leu Asp 
        35                  40                  45              


Gly Pro Ile Phe Met Pro Lys Asp Gly Glu Cys His Lys Leu Ser Asn 
    50                  55                  60                  


Ala Ala Leu Pro Leu Ala Met Gly His Glu Met Ser Gly Ile Val Ser 
65                  70                  75                  80  


Lys Val Gly Pro Lys Val Thr Lys Val Lys Val Gly Asp His Val Val 
                85                  90                  95      


Val Asp Ala Ala Ser Ser Cys Ala Asp Leu His Cys Trp Pro His Ser 
            100                 105                 110         


Lys Phe Tyr Asn Ser Lys Pro Cys Asp Ala Cys Gln Arg Gly Ser Glu 
        115                 120                 125             


Asn Leu Cys Thr His Ala Gly Phe Val Gly Leu Gly Val Ile Ser Gly 
    130                 135                 140                 


Gly Phe Ala Glu Gln Val Val Val Ser Gln His His Ile Ile Pro Val 
145                 150                 155                 160 


Pro Lys Glu Ile Pro Leu Asp Val Ala Ala Leu Val Glu Pro Leu Ser 
                165                 170                 175     


Val Thr Trp His Ala Val Lys Ile Ser Gly Phe Lys Lys Gly Ser Ser 
            180                 185                 190         


Ala Leu Val Leu Gly Ala Gly Pro Ile Gly Leu Cys Thr Ile Leu Val 
        195                 200                 205             


Leu Lys Gly Met Gly Ala Ser Lys Ile Val Val Ser Glu Ile Ala Glu 
    210                 215                 220                 


Arg Arg Ile Glu Met Ala Lys Lys Leu Gly Val Glu Val Phe Asn Pro 
225                 230                 235                 240 


Ser Lys His Gly His Lys Ser Ile Glu Ile Leu Arg Gly Leu Thr Lys 
                245                 250                 255     


Ser His Asp Gly Phe Asp Tyr Ser Tyr Asp Cys Ser Gly Ile Gln Val 
            260                 265                 270         


Thr Phe Glu Thr Ser Leu Lys Ala Leu Thr Phe Lys Gly Thr Ala Thr 
        275                 280                 285             


Asn Ile Ala Val Trp Gly Pro Lys Pro Val Pro Phe Gln Pro Met Asp 
    290                 295                 300                 


Val Thr Leu Gln Glu Lys Val Met Thr Gly Ser Ile Gly Tyr Val Val 
305                 310                 315                 320 


Glu Asp Phe Glu Glu Val Val Arg Ala Ile His Asn Gly Asp Ile Ala 
                325                 330                 335     


Met Glu Asp Cys Lys Gln Leu Ile Thr Gly Lys Gln Arg Ile Glu Asp 
            340                 345                 350         


Gly Trp Glu Lys Gly Phe Gln Glu Leu Met Asp His Lys Glu Ser Asn 
        355                 360                 365             


Val Lys Ile Leu Leu Thr Pro Asn Asn His Gly Glu Met Lys 
    370                 375                 380         


<210>  36
<211>  1149
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  36
atgagagctt tggcatattt caagaagggt gatattcact tcactaatga tatccctagg       60

ccagaaatcc aaaccgacga tgaggttatt atcgacgtct cttggtgtgg gatttgtggc      120

tcggatcttc acgagtactt ggatggtcca atcttcatgc ctaaagatgg agagtgccat      180

aaattatcca acgctgcttt acctctggca atgggccatg agatgtcagg aattgtttcc      240

aaggttggtc ctaaagtgac aaaggtgaag gttggcgacc acgtggtcgt tgatgctgcc      300

agcagttgtg cggacctgca ttgctggcca cactccaaat tttacaattc caaaccatgt      360

gatgcttgtc agaggggcag tgaaaatcta tgtacccacg ccggttttgt aggactaggt      420

gtgatcagtg gtggctttgc tgaacaagtc gtagtctctc aacatcacat tatcccggtt      480

ccaaaggaaa ttcctctaga tgtggctgct ttagttgagc ctctttctgt cacctggcat      540

gctgttaaga tttctggttt caaaaaaggc agttcagcct tggttcttgg tgcaggtccc      600

attgggttgt gtaccatttt ggtacttaag ggaatggggg ctagtaaaat tgtagtgtct      660

gaaattgcag agagaagaat agaaatggcc aagaaactgg gcgttgaggt gttcaatccc      720

tccaagcacg gtcataaatc tatagagata ctacgtggtt tgaccaagag ccatgatggg      780

tttgattaca gttatgattg ttctggtatt caagttactt tcgaaacctc tttgaaggca      840

ttaacattca aggggacagc caccaacatt gcagtttggg gtccaaaacc tgtcccattc      900

caaccaatgg atgtgactct ccaagagaaa gttatgactg gttcgatcgg ctatgttgtc      960

gaagacttcg aagaagttgt tcgtgccatc cacaacggag acatcgccat ggaagattgt     1020

aagcaactaa tcactggtaa gcaaaggatt gaggacggtt gggaaaaggg attccaagag     1080

ttgatggatc acaaggaatc caacgttaag attctattga cgcctaacaa tcacggtgaa     1140

atgaagtaa                                                             1149


<210>  37
<211>  417
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  37

Met Arg Ala Leu Ala Tyr Phe Gly Lys Gly Asn Ile Arg Phe Thr Asn 
1               5                   10                  15      


His Leu Lys Glu Pro His Ile Val Ala Pro Asp Glu Leu Val Ile Asp 
            20                  25                  30          


Ile Glu Trp Cys Gly Ile Cys Gly Thr Asp Leu His Glu Tyr Thr Asp 
        35                  40                  45              


Gly Pro Ile Phe Phe Pro Glu Asp Gly His Thr His Glu Ile Ser His 
    50                  55                  60                  


Asn Pro Leu Pro Gln Ala Met Gly His Glu Met Ala Gly Thr Val Leu 
65                  70                  75                  80  


Glu Val Gly Pro Gly Val Lys Asn Leu Lys Val Gly Asp Lys Val Val 
                85                  90                  95      


Val Glu Pro Thr Gly Thr Cys Arg Asp Arg Tyr Arg Trp Pro Leu Ser 
            100                 105                 110         


Pro Asn Val Asp Lys Glu Trp Cys Ala Ala Cys Lys Lys Gly Tyr Tyr 
        115                 120                 125             


Asn Ile Cys Ser Tyr Leu Gly Leu Cys Gly Ala Gly Val Gln Ser Gly 
    130                 135                 140                 


Gly Phe Ala Glu Arg Val Val Met Asn Glu Ser His Cys Tyr Lys Val 
145                 150                 155                 160 


Pro Asp Phe Val Pro Leu Asp Val Ala Ala Leu Ile Gln Pro Leu Ala 
                165                 170                 175     


Val Cys Trp His Ala Ile Arg Val Cys Glu Phe Lys Ala Gly Ser Thr 
            180                 185                 190         


Ala Leu Ile Ile Gly Ala Gly Pro Ile Gly Leu Gly Thr Ile Leu Ala 
        195                 200                 205             


Leu Asn Ala Ala Gly Cys Lys Asp Ile Val Val Ser Glu Pro Ala Lys 
    210                 215                 220                 


Val Arg Arg Glu Leu Ala Glu Lys Met Gly Ala Arg Val Tyr Asp Pro 
225                 230                 235                 240 


Thr Ala His Ala Ala Lys Glu Ser Ile Asp Tyr Leu Arg Ser Ile Ala 
                245                 250                 255     


Asp Gly Gly Asp Gly Phe Asp Tyr Thr Phe Asp Cys Ser Gly Leu Glu 
            260                 265                 270         


Val Thr Leu Asn Ala Ala Ile Gln Cys Leu Thr Phe Arg Gly Thr Ala 
        275                 280                 285             


Val Asn Leu Ala Met Trp Gly His His Lys Ile Gln Phe Ser Pro Met 
    290                 295                 300                 


Asp Ile Thr Leu His Glu Arg Lys Tyr Thr Gly Ser Met Cys Tyr Thr 
305                 310                 315                 320 


His His Asp Phe Glu Ala Val Ile Glu Ala Leu Glu Glu Gly Arg Ile 
                325                 330                 335     


Asp Ile Asp Arg Ala Arg His Met Ile Thr Gly Arg Val Asn Ile Glu 
            340                 345                 350         


Asp Gly Leu Asp Gly Ala Ile Met Lys Leu Ile Asn Glu Lys Glu Ser 
        355                 360                 365             


Thr Ile Lys Ile Ile Leu Thr Pro Asn Asn His Gly Glu Leu Asn Arg 
    370                 375                 380                 


Glu Ala Asp Asn Glu Lys Lys Glu Ile Ser Glu Leu Ser Ser Arg Lys 
385                 390                 395                 400 


Asp Gln Glu Arg Leu Arg Glu Ser Ile Asn Glu Ala Lys Leu Arg His 
                405                 410                 415     


Thr 
    


<210>  38
<211>  1254
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  38
atgagagcct tagcgtattt cggtaaaggt aacatcagat tcaccaacca tttaaaggag       60

ccacatattg tggcgcccga tgagcttgtg attgatatcg aatggtgtgg tatttgcggt      120

acggacctgc atgagtacac agatggtcct atctttttcc cagaagatgg acacacacat      180

gagattagtc ataacccatt gccacaggcg atgggccacg aaatggctgg taccgttttg      240

gaggtgggcc ctggtgtgaa aaacttgaaa gtgggagaca aggtagttgt cgagcccaca      300

ggtacatgca gagaccggta tcgttggccc ctgtcgccaa acgttgacaa ggaatggtgc      360

gctgcttgca aaaagggcta ctataacatt tgttcatatt tggggctttg tggtgcgggt      420

gtgcagagcg gtggatttgc agaacgtgtt gtgatgaacg aatctcactg ctacaaagta      480

ccggacttcg tgcccttaga cgttgcagct ttgattcaac cgttggctgt gtgctggcat      540

gcaattagag tctgcgagtt caaagcaggc tctacggctt tgatcattgg tgctggcccc      600

atcggactgg gcacgatact ggcgttgaac gctgcaggtt gcaaggacat cgtcgtttca      660

gagcctgcca aggtaagaag agaactggct gaaaaaatgg gtgccagggt ttacgaccca      720

actgcgcacg ctgccaagga gagcattgat tatctgaggt cgattgctga tggtggagac      780

ggcttcgatt acacatttga ttgctccggg ttggaagtca cattgaatgc tgctattcag      840

tgtctcactt tcagaggcac cgcagtgaac ttggccatgt ggggccatca caagatacag      900

ttttctccga tggacatcac attgcatgaa agaaagtaca cagggtccat gtgctacaca      960

caccacgatt ttgaggcagt aatagaagct ttggaagaag gcaggattga cattgataga     1020

gcaagacata tgataacggg cagagtcaac attgaggacg gccttgatgg cgccatcatg     1080

aagctgataa acgagaagga gtctacaatc aagattattc tgactccaaa caatcacgga     1140

gagttgaaca gggaagccga taatgagaag aaagaaattt ccgagctgag cagtcggaaa     1200

gatcaagaaa gactacgaga atcaataaac gaggctaaac tgcgtcacac atga           1254


<210>  39
<211>  900
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  39

Met Pro Gly Asn Leu Ser Phe Lys Asp Arg Val Val Val Ile Thr Gly 
1               5                   10                  15      


Ala Gly Gly Gly Leu Gly Lys Val Tyr Ala Leu Ala Tyr Ala Ser Arg 
            20                  25                  30          


Gly Ala Lys Val Val Val Asn Asp Leu Gly Gly Thr Leu Gly Gly Ser 
        35                  40                  45              


Gly His Asn Ser Lys Ala Ala Asp Leu Val Val Asp Glu Ile Lys Lys 
    50                  55                  60                  


Ala Gly Gly Ile Ala Val Ala Asn Tyr Asp Ser Val Asn Glu Asn Gly 
65                  70                  75                  80  


Glu Lys Ile Ile Glu Thr Ala Ile Lys Glu Phe Gly Arg Val Asp Val 
                85                  90                  95      


Leu Ile Asn Asn Ala Gly Ile Leu Arg Asp Val Ser Phe Ala Lys Met 
            100                 105                 110         


Thr Glu Arg Glu Phe Ala Ser Val Val Asp Val His Leu Thr Gly Gly 
        115                 120                 125             


Tyr Lys Leu Ser Arg Ala Ala Trp Pro Tyr Met Arg Ser Gln Lys Phe 
    130                 135                 140                 


Gly Arg Ile Ile Asn Thr Ala Ser Pro Ala Gly Leu Phe Gly Asn Phe 
145                 150                 155                 160 


Gly Gln Ala Asn Tyr Ser Ala Ala Lys Met Gly Leu Val Gly Leu Ala 
                165                 170                 175     


Glu Thr Leu Ala Lys Glu Gly Ala Lys Tyr Asn Ile Asn Val Asn Ser 
            180                 185                 190         


Ile Ala Pro Leu Ala Arg Ser Arg Met Thr Glu Asn Val Leu Pro Pro 
        195                 200                 205             


His Ile Leu Lys Gln Leu Gly Pro Glu Lys Ile Val Pro Leu Val Leu 
    210                 215                 220                 


Tyr Leu Thr His Glu Ser Thr Lys Val Ser Asn Ser Ile Phe Glu Leu 
225                 230                 235                 240 


Ala Ala Gly Phe Phe Gly Gln Leu Arg Trp Glu Arg Ser Ser Gly Gln 
                245                 250                 255     


Ile Phe Asn Pro Asp Pro Lys Thr Tyr Thr Pro Glu Ala Ile Leu Asn 
            260                 265                 270         


Lys Trp Lys Glu Ile Thr Asp Tyr Arg Asp Lys Pro Phe Asn Lys Thr 
        275                 280                 285             


Gln His Pro Tyr Gln Leu Ser Asp Tyr Asn Asp Leu Ile Thr Lys Ala 
    290                 295                 300                 


Lys Lys Leu Pro Pro Asn Glu Gln Gly Ser Val Lys Ile Lys Ser Leu 
305                 310                 315                 320 


Cys Asn Lys Val Val Val Val Thr Gly Ala Gly Gly Gly Leu Gly Lys 
                325                 330                 335     


Ser His Ala Ile Trp Phe Ala Arg Tyr Gly Ala Lys Val Val Val Asn 
            340                 345                 350         


Asp Ile Lys Asp Pro Phe Ser Val Val Glu Glu Ile Asn Lys Leu Tyr 
        355                 360                 365             


Gly Glu Gly Thr Ala Ile Pro Asp Ser His Asp Val Val Thr Glu Ala 
    370                 375                 380                 


Pro Leu Ile Ile Gln Thr Ala Ile Ser Lys Phe Gln Arg Val Asp Ile 
385                 390                 395                 400 


Leu Val Asn Asn Ala Gly Ile Leu Arg Asp Lys Ser Phe Leu Lys Met 
                405                 410                 415     


Lys Asp Glu Glu Trp Phe Ala Val Leu Lys Val His Leu Phe Ser Thr 
            420                 425                 430         


Phe Ser Leu Ser Lys Ala Val Trp Pro Ile Phe Thr Lys Gln Lys Ser 
        435                 440                 445             


Gly Phe Ile Ile Asn Thr Thr Ser Thr Ser Gly Ile Tyr Gly Asn Phe 
    450                 455                 460                 


Gly Gln Ala Asn Tyr Ala Ala Ala Lys Ala Ala Ile Leu Gly Phe Ser 
465                 470                 475                 480 


Lys Thr Ile Ala Leu Glu Gly Ala Lys Arg Gly Ile Ile Val Asn Val 
                485                 490                 495     


Ile Ala Pro His Ala Glu Thr Ala Met Thr Lys Thr Ile Phe Ser Glu 
            500                 505                 510         


Lys Glu Leu Ser Asn His Phe Asp Ala Ser Gln Val Ser Pro Leu Val 
        515                 520                 525             


Val Leu Leu Ala Ser Glu Glu Leu Gln Lys Tyr Ser Gly Arg Arg Val 
    530                 535                 540                 


Ile Gly Gln Leu Phe Glu Val Gly Gly Gly Trp Cys Gly Gln Thr Arg 
545                 550                 555                 560 


Trp Gln Arg Ser Ser Gly Tyr Val Ser Ile Lys Glu Thr Ile Glu Pro 
                565                 570                 575     


Glu Glu Ile Lys Glu Asn Trp Asn His Ile Thr Asp Phe Ser Arg Asn 
            580                 585                 590         


Thr Ile Asn Pro Ser Ser Thr Glu Glu Ser Ser Met Ala Thr Leu Gln 
        595                 600                 605             


Ala Val Gln Lys Ala His Ser Ser Lys Glu Leu Asp Asp Gly Leu Phe 
    610                 615                 620                 


Lys Tyr Thr Thr Lys Asp Cys Ile Leu Tyr Asn Leu Gly Leu Gly Cys 
625                 630                 635                 640 


Thr Ser Lys Glu Leu Lys Tyr Thr Tyr Glu Asn Asp Pro Asp Phe Gln 
                645                 650                 655     


Val Leu Pro Thr Phe Ala Val Ile Pro Phe Met Gln Ala Thr Ala Thr 
            660                 665                 670         


Leu Ala Met Asp Asn Leu Val Asp Asn Phe Asn Tyr Ala Met Leu Leu 
        675                 680                 685             


His Gly Glu Gln Tyr Phe Lys Leu Cys Thr Pro Thr Met Pro Ser Asn 
    690                 695                 700                 


Gly Thr Leu Lys Thr Leu Ala Lys Pro Leu Gln Val Leu Asp Lys Asn 
705                 710                 715                 720 


Gly Lys Ala Ala Leu Val Val Gly Gly Phe Glu Thr Tyr Asp Ile Lys 
                725                 730                 735     


Thr Lys Lys Leu Ile Ala Tyr Asn Glu Gly Ser Phe Phe Ile Arg Gly 
            740                 745                 750         


Ala His Val Pro Pro Glu Lys Glu Val Arg Asp Gly Lys Arg Ala Lys 
        755                 760                 765             


Phe Ala Val Gln Asn Phe Glu Val Pro His Gly Lys Val Pro Asp Phe 
    770                 775                 780                 


Glu Ala Glu Ile Ser Thr Asn Lys Asp Gln Ala Ala Leu Tyr Arg Leu 
785                 790                 795                 800 


Ser Gly Asp Phe Asn Pro Leu His Ile Asp Pro Thr Leu Ala Lys Ala 
                805                 810                 815     


Val Lys Phe Pro Thr Pro Ile Leu His Gly Leu Cys Thr Leu Gly Ile 
            820                 825                 830         


Ser Ala Lys Ala Leu Phe Glu His Tyr Gly Pro Tyr Glu Glu Leu Lys 
        835                 840                 845             


Val Arg Phe Thr Asn Val Val Phe Pro Gly Asp Thr Leu Lys Val Lys 
    850                 855                 860                 


Ala Trp Lys Gln Gly Ser Val Val Val Phe Gln Thr Ile Asp Thr Thr 
865                 870                 875                 880 


Arg Asn Val Ile Val Leu Asp Asn Ala Ala Val Lys Leu Ser Gln Ala 
                885                 890                 895     


Lys Ser Lys Leu 
            900 


<210>  40
<211>  2703
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  40
atgcctggaa atttatcctt caaagataga gttgttgtaa tcacgggcgc tggagggggc       60

ttaggtaagg tgtatgcact agcttacgca agcagaggtg caaaagtggt cgtcaatgat      120

ctaggtggca ctttgggtgg ttcaggacat aactccaaag ctgcagactt agtggtggat      180

gagataaaaa aagccggagg tatagctgtg gcaaattacg actctgttaa tgaaaatgga      240

gagaaaataa ttgaaacggc tataaaagaa ttcggcaggg ttgatgtact aattaacaac      300

gctggaatat taagggatgt ttcatttgca aagatgacag aacgtgagtt tgcatctgtg      360

gtagatgttc atttgacagg tggctataag ctatcgcgtg ctgcttggcc ttatatgcgc      420

tctcagaaat ttggtagaat cattaacacc gcttcccctg ccggtctatt tggaaatttt      480

ggtcaagcta attattcagc agctaaaatg ggcttagttg gtttggcgga aaccctcgcg      540

aaggagggtg ccaaatacaa cattaatgtt aattcaattg cgccattggc tagatcacgt      600

atgacagaaa acgtgttacc accacatatc ttgaaacagt taggaccgga aaaaattgtt      660

cccttagtac tctatttgac acacgaaagt acgaaagtgt caaactccat ttttgaactc      720

gctgctggat tctttggaca gctcagatgg gagaggtctt ctggacaaat tttcaatcca      780

gaccccaaga catatactcc tgaagcaatt ttaaataagt ggaaggaaat cacagactat      840

agggacaagc catttaacaa aactcagcat ccatatcaac tctcggatta taatgattta      900

atcaccaaag caaaaaaatt acctcccaat gaacaaggct cagtgaaaat caagtcgctt      960

tgcaacaaag tcgtagtagt tacgggtgca ggaggtggtc ttgggaagtc tcatgcaatc     1020

tggtttgcac ggtacggtgc gaaggtagtt gtaaatgaca tcaaggatcc tttttcagtt     1080

gttgaagaaa taaataaact atatggtgaa ggcacagcca ttccagattc ccatgatgtg     1140

gtcaccgaag ctcctctcat tatccaaact gcaataagta agtttcagag agtagacatc     1200

ttggtcaata acgctggtat tttgcgtgac aaatcttttt taaaaatgaa agatgaggaa     1260

tggtttgctg tcctgaaagt ccaccttttt tccacatttt cattgtcaaa agcagtatgg     1320

ccaatattta ccaaacaaaa gtctggattt attatcaata ctacttctac ctcaggaatt     1380

tatggtaatt ttggacaggc caattatgcc gctgcaaaag ccgccatttt aggattcagt     1440

aaaactattg cactggaagg tgccaagaga ggaattattg ttaatgttat cgctcctcat     1500

gcagaaacgg ctatgacaaa gactatattc tcggagaagg aattatcaaa ccactttgat     1560

gcatctcaag tctccccact tgttgttttg ttggcatctg aagaactaca aaagtattct     1620

ggaagaaggg ttattggcca attattcgaa gttggcggtg gttggtgtgg gcaaaccaga     1680

tggcaaagaa gttccggtta tgtttctatt aaagagacta ttgaaccgga agaaattaaa     1740

gaaaattgga accacatcac tgatttcagt cgcaacacta tcaacccgag ctccacagag     1800

gagtcttcta tggcaacctt gcaagccgtg caaaaagcgc actcttcaaa ggagttggat     1860

gatggattat tcaagtacac taccaaggat tgtatcttgt acaatttagg acttggatgc     1920

acaagcaaag agcttaagta cacctacgag aatgatccag acttccaagt tttgcccacg     1980

ttcgccgtca ttccatttat gcaagctact gccacactag ctatggacaa tttagtcgat     2040

aacttcaatt atgcaatgtt actgcatgga gaacaatatt ttaagctctg cacgccgaca     2100

atgccaagta atggaactct aaagacactt gctaaacctt tacaagtact tgacaagaat     2160

ggtaaagccg ctttagttgt tggtggcttc gaaacttatg acattaaaac taagaaactc     2220

atagcttata acgaaggatc gttcttcatc aggggcgcac atgtacctcc agaaaaggaa     2280

gtgagggatg ggaaaagagc caagtttgct gtccaaaatt ttgaagtgcc acatggaaag     2340

gtaccagatt ttgaggcgga gatttctacg aataaagatc aagccgcatt gtacaggtta     2400

tctggcgatt tcaatccttt acatatcgat cccacgctag ccaaagcagt taaatttcct     2460

acgccaattc tgcatgggct ttgtacatta ggtattagtg cgaaagcatt gtttgaacat     2520

tatggtccat atgaggagtt gaaagtgaga tttaccaatg ttgttttccc aggtgatact     2580

ctaaaggtta aagcttggaa gcaaggctcg gttgtcgttt ttcaaacaat tgatacgacc     2640

agaaacgtca ttgtattgga taacgccgct gtaaaactat cgcaggcaaa atctaaacta     2700

taa                                                                   2703


<210>  41
<211>  312
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  41

Met Pro Ala Thr Leu His Asp Ser Thr Lys Ile Leu Ser Leu Asn Thr 
1               5                   10                  15      


Gly Ala Gln Ile Pro Gln Ile Gly Leu Gly Thr Trp Gln Ser Lys Glu 
            20                  25                  30          


Asn Asp Ala Tyr Lys Ala Val Leu Thr Ala Leu Lys Asp Gly Tyr Arg 
        35                  40                  45              


His Ile Asp Thr Ala Ala Ile Tyr Arg Asn Glu Asp Gln Val Gly Gln 
    50                  55                  60                  


Ala Ile Lys Asp Ser Gly Val Pro Arg Glu Glu Ile Phe Val Thr Thr 
65                  70                  75                  80  


Lys Leu Trp Cys Thr Gln His His Glu Pro Glu Val Ala Leu Asp Gln 
                85                  90                  95      


Ser Leu Lys Arg Leu Gly Leu Asp Tyr Val Asp Leu Tyr Leu Met His 
            100                 105                 110         


Trp Pro Ala Arg Leu Asp Pro Ala Tyr Ile Lys Asn Glu Asp Ile Leu 
        115                 120                 125             


Ser Val Pro Thr Lys Lys Asp Gly Ser Arg Ala Val Asp Ile Thr Asn 
    130                 135                 140                 


Trp Asn Phe Ile Lys Thr Trp Glu Leu Met Gln Glu Leu Pro Lys Thr 
145                 150                 155                 160 


Gly Lys Thr Lys Ala Val Gly Val Ser Asn Phe Ser Ile Asn Asn Leu 
                165                 170                 175     


Lys Asp Leu Leu Ala Ser Gln Gly Asn Lys Leu Thr Pro Ala Ala Asn 
            180                 185                 190         


Gln Val Glu Ile His Pro Leu Leu Pro Gln Asp Glu Leu Ile Asn Phe 
        195                 200                 205             


Cys Lys Ser Lys Gly Ile Val Val Glu Ala Tyr Ser Pro Leu Gly Ser 
    210                 215                 220                 


Thr Asp Ala Pro Leu Leu Lys Glu Pro Val Ile Leu Glu Ile Ala Lys 
225                 230                 235                 240 


Lys Asn Asn Val Gln Pro Gly His Val Val Ile Ser Trp His Val Gln 
                245                 250                 255     


Arg Gly Tyr Val Val Leu Pro Lys Ser Val Asn Pro Asp Arg Ile Lys 
            260                 265                 270         


Thr Asn Arg Lys Ile Phe Thr Leu Ser Thr Glu Asp Phe Glu Ala Ile 
        275                 280                 285             


Asn Asn Ile Ser Lys Glu Lys Gly Glu Lys Arg Val Val His Pro Asn 
    290                 295                 300                 


Trp Ser Pro Phe Glu Val Phe Lys 
305                 310         


<210>  42
<211>  939
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  42
atgcctgcta ctttacatga ttctacgaaa atcctttctc taaatactgg agcccaaatc       60

cctcaaatag gtttaggtac gtggcagtcg aaagagaacg atgcttataa ggctgtttta      120

accgctttga aagatggcta ccgacacatt gatactgctg ctatttaccg taatgaagac      180

caagtcggtc aagccatcaa ggattcaggt gttcctcggg aagaaatctt tgttactaca      240

aagttatggt gtacacaaca ccacgaacct gaagtagcgc tggatcaatc actaaagagg      300

ttaggattgg actacgtaga cttatatttg atgcattggc ctgccagatt agatccagcc      360

tacatcaaaa atgaagacat cttgagtgtg ccaacaaaga aggatggttc tcgtgcagtg      420

gatatcacca attggaattt catcaaaacc tgggaattaa tgcaggaact accaaagact      480

ggtaaaacta aggccgttgg agtctccaac ttttctataa ataacctgaa agatctatta      540

gcatctcaag gtaataagct tacgccagct gctaaccaag tcgaaataca tccattacta      600

cctcaagacg aattgattaa tttttgtaaa agtaaaggca ttgtggttga agcttattct      660

ccgttaggta gtaccgatgc tccactattg aaggaaccgg ttatccttga aattgcgaag      720

aaaaataacg ttcaacccgg acacgttgtt attagctggc acgtccaaag aggttatgtt      780

gtcttgccaa aatctgtgaa tcccgatcga atcaaaacga acaggaaaat atttactttg      840

tctactgagg actttgaagc tatcaataac atatcgaagg aaaagggcga aaaaagggtt      900

gtacatccaa attggtctcc tttcgaagta ttcaagtaa                             939


<210>  43
<211>  350
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  43

Met Ser Lys Lys Pro Ile Val Leu Lys Leu Gly Lys Asp Ala Phe Gly 
1               5                   10                  15      


Asp Gln Ala Trp Gly Glu Leu Glu Lys Ile Ala Asp Val Ile Thr Ile 
            20                  25                  30          


Pro Glu Ser Thr Thr Arg Glu Gln Phe Leu Arg Glu Val Lys Asp Pro 
        35                  40                  45              


Gln Asn Lys Leu Ser Gln Val Gln Val Ile Thr Arg Thr Ala Arg Ser 
    50                  55                  60                  


Val Lys Asn Thr Gly Arg Phe Asp Glu Glu Leu Ala Leu Ala Leu Pro 
65                  70                  75                  80  


Ser Ser Val Val Ala Val Cys His Thr Gly Ala Gly Tyr Asp Gln Ile 
                85                  90                  95      


Asp Val Glu Pro Phe Lys Lys Arg His Ile Gln Val Ala Asn Val Pro 
            100                 105                 110         


Asp Leu Val Ser Asn Ala Thr Ala Asp Thr His Val Phe Leu Leu Leu 
        115                 120                 125             


Gly Ala Leu Arg Asn Phe Gly Ile Gly Asn Arg Arg Leu Ile Glu Gly 
    130                 135                 140                 


Asn Trp Pro Glu Ala Gly Pro Ala Cys Gly Ser Pro Phe Gly Tyr Asp 
145                 150                 155                 160 


Pro Glu Gly Lys Thr Val Gly Ile Leu Gly Leu Gly Arg Ile Gly Arg 
                165                 170                 175     


Cys Ile Leu Glu Arg Leu Lys Pro Phe Gly Phe Glu Asn Phe Ile Tyr 
            180                 185                 190         


His Asn Arg His Gln Leu Pro Ser Glu Glu Glu His Gly Cys Glu Tyr 
        195                 200                 205             


Val Gly Phe Glu Glu Phe Leu Lys Arg Ser Asp Ile Val Ser Val Asn 
    210                 215                 220                 


Val Pro Leu Asn His Asn Thr His His Leu Ile Asn Ala Glu Thr Ile 
225                 230                 235                 240 


Glu Lys Met Lys Asp Gly Val Val Ile Val Asn Thr Ala Arg Gly Ala 
                245                 250                 255     


Val Ile Asp Glu Gln Ala Met Thr Asp Ala Leu Arg Ser Gly Lys Ile 
            260                 265                 270         


Arg Ser Ala Gly Leu Asp Val Phe Glu Tyr Glu Pro Lys Ile Ser Lys 
        275                 280                 285             


Glu Leu Leu Ser Met Ser Gln Val Leu Gly Leu Pro His Met Gly Thr 
    290                 295                 300                 


His Ser Val Glu Thr Arg Lys Lys Met Glu Glu Leu Val Val Glu Asn 
305                 310                 315                 320 


Ala Lys Asn Val Ile Leu Thr Gly Lys Val Leu Thr Ile Val Pro Glu 
                325                 330                 335     


Leu Gln Asn Glu Asp Trp Pro Asn Glu Ser Lys Pro Leu Val 
            340                 345                 350 


<210>  44
<211>  1053
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  44
atgagtaaga aaccaattgt tttgaaatta ggaaaggatg cctttggtga ccaagcctgg       60

ggggaattgg aaaagattgc ggatgtaatt accatccctg aatccaccac tagagaacag      120

tttttgcggg aggtaaaaga cccacaaaat aagctctccc aagtacaagt cattactaga      180

acagcaagga gtgtgaaaaa caccggtaga tttgatgaag agcttgctct tgctttgccc      240

tcctccgtag tggctgtatg tcatactggt gctggttatg accaaattga tgttgagcca      300

ttcaagaaaa ggcacatcca ggttgccaat gttcctgatt tagttagcaa tgctaccgct      360

gatacgcatg tatttttgct attgggtgcc ctaagaaact tcggtattgg taacagaagg      420

ttgatcgagg gaaactggcc ggaggcagga cccgcatgtg gttctccctt tggatacgac      480

cctgaaggga aaacagttgg tatactgggt ctaggtagga ttggtcgttg tattttagag      540

agattgaagc cgtttgggtt cgagaatttc atatatcata acagacacca gcttccttcc      600

gaagaagagc atggttgtga atatgtagga ttcgaggagt ttttgaagcg ttctgatata      660

gtatctgtaa acgtcccact gaaccacaat actcaccatc taatcaatgc agagactatt      720

gaaaaaatga aagatggtgt agttattgtt aacacagcgc gtggtgccgt gatagacgaa      780

caagccatga ctgatgcttt gcgttctgga aagattagaa gtgctggttt ggacgttttc      840

gaatatgagc caaaaatatc caaagagtta ttatcgatgt cccaagtctt aggactgcct      900

catatgggca cacatagtgt agaaacaaga aagaaaatgg aagaactggt cgttgaaaat      960

gcaaagaatg tgatattgac cgggaaagtc ttgactattg ttccggaatt acaaaatgaa     1020

gactggccca atgaatctaa gccattagtt tga                                  1053


<210>  45
<211>  391
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  45

Met Ser Ala Ala Ala Asp Arg Leu Asn Leu Thr Ser Gly His Leu Asn 
1               5                   10                  15      


Ala Gly Arg Lys Arg Ser Ser Ser Ser Val Ser Leu Lys Ala Ala Glu 
            20                  25                  30          


Lys Pro Phe Lys Val Thr Val Ile Gly Ser Gly Asn Trp Gly Thr Thr 
        35                  40                  45              


Ile Ala Lys Val Val Ala Glu Asn Cys Lys Gly Tyr Pro Glu Val Phe 
    50                  55                  60                  


Ala Pro Ile Val Gln Met Trp Val Phe Glu Glu Glu Ile Asn Gly Glu 
65                  70                  75                  80  


Lys Leu Thr Glu Ile Ile Asn Thr Arg His Gln Asn Val Lys Tyr Leu 
                85                  90                  95      


Pro Gly Ile Thr Leu Pro Asp Asn Leu Val Ala Asn Pro Asp Leu Ile 
            100                 105                 110         


Asp Ser Val Lys Asp Val Asp Ile Ile Val Phe Asn Ile Pro His Gln 
        115                 120                 125             


Phe Leu Pro Arg Ile Cys Ser Gln Leu Lys Gly His Val Asp Ser His 
    130                 135                 140                 


Val Arg Ala Ile Ser Cys Leu Lys Gly Phe Glu Val Gly Ala Lys Gly 
145                 150                 155                 160 


Val Gln Leu Leu Ser Ser Tyr Ile Thr Glu Glu Leu Gly Ile Gln Cys 
                165                 170                 175     


Gly Ala Leu Ser Gly Ala Asn Ile Ala Thr Glu Val Ala Gln Glu His 
            180                 185                 190         


Trp Ser Glu Thr Thr Val Ala Tyr His Ile Pro Lys Asp Phe Arg Gly 
        195                 200                 205             


Glu Gly Lys Asp Val Asp His Lys Val Leu Lys Ala Leu Phe His Arg 
    210                 215                 220                 


Pro Tyr Phe His Val Ser Val Ile Glu Asp Val Ala Gly Ile Ser Ile 
225                 230                 235                 240 


Cys Gly Ala Leu Lys Asn Val Val Ala Leu Gly Cys Gly Phe Val Glu 
                245                 250                 255     


Gly Leu Gly Trp Gly Asn Asn Ala Ser Ala Ala Ile Gln Arg Val Gly 
            260                 265                 270         


Leu Gly Glu Ile Ile Arg Phe Gly Gln Met Phe Phe Pro Glu Ser Arg 
        275                 280                 285             


Glu Glu Thr Tyr Tyr Gln Glu Ser Ala Gly Val Ala Asp Leu Ile Thr 
    290                 295                 300                 


Thr Cys Ala Gly Gly Arg Asn Val Lys Val Ala Arg Leu Met Ala Thr 
305                 310                 315                 320 


Ser Gly Lys Asp Ala Trp Glu Cys Glu Lys Glu Leu Leu Asn Gly Gln 
                325                 330                 335     


Ser Ala Gln Gly Leu Ile Thr Cys Lys Glu Val His Glu Trp Leu Glu 
            340                 345                 350         


Thr Cys Gly Ser Val Glu Asp Phe Pro Leu Phe Glu Ala Val Tyr Gln 
        355                 360                 365             


Ile Val Tyr Asn Asn Tyr Pro Met Lys Asn Leu Pro Asp Met Ile Glu 
    370                 375                 380                 


Glu Leu Asp Leu His Glu Asp 
385                 390     


<210>  46
<211>  1176
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  46
atgtctgctg ctgctgatag attaaactta acttccggcc acttgaatgc tggtagaaag       60

agaagttcct cttctgtttc tttgaaggct gccgaaaagc ctttcaaggt tactgtgatt      120

ggatctggta actggggtac tactattgcc aaggtggttg ccgaaaattg taagggatac      180

ccagaagttt tcgctccaat agtacaaatg tgggtgttcg aagaagagat caatggtgaa      240

aaattgactg aaatcataaa tactagacat caaaacgtga aatacttgcc tggcatcact      300

ctacccgaca atttggttgc taatccagac ttgattgatt cagtcaagga tgtcgacatc      360

atcgttttca acattccaca tcaatttttg ccccgtatct gtagccaatt gaaaggtcat      420

gttgattcac acgtcagagc tatctcctgt ctaaagggtt ttgaagttgg tgctaaaggt      480

gtccaattgc tatcctctta catcactgag gaactaggta ttcaatgtgg tgctctatct      540

ggtgctaaca ttgccaccga agtcgctcaa gaacactggt ctgaaacaac agttgcttac      600

cacattccaa aggatttcag aggcgagggc aaggacgtcg accataaggt tctaaaggcc      660

ttgttccaca gaccttactt ccacgttagt gtcatcgaag atgttgctgg tatctccatc      720

tgtggtgctt tgaagaacgt tgttgcctta ggttgtggtt tcgtcgaagg tctaggctgg      780

ggtaacaacg cttctgctgc catccaaaga gtcggtttgg gtgagatcat cagattcggt      840

caaatgtttt tcccagaatc tagagaagaa acatactacc aagagtctgc tggtgttgct      900

gatttgatca ccacctgcgc tggtggtaga aacgtcaagg ttgctaggct aatggctact      960

tctggtaagg acgcctggga atgtgaaaag gagttgttga atggccaatc cgctcaaggt     1020

ttaattacct gcaaagaagt tcacgaatgg ttggaaacat gtggctctgt cgaagacttc     1080

ccattatttg aagccgtata ccaaatcgtt tacaacaact acccaatgaa gaacctgccg     1140

gacatgattg aagaattaga tctacatgaa gattag                               1176


<210>  47
<211>  799
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  47

Met Val Leu Pro Ile Leu Pro Leu Ile Asp Asp Leu Ala Ser Trp Asn 
1               5                   10                  15      


Ser Lys Lys Glu Tyr Val Ser Leu Val Gly Gln Val Leu Leu Asp Gly 
            20                  25                  30          


Ser Ser Leu Ser Asn Glu Glu Ile Leu Gln Phe Ser Lys Glu Glu Glu 
        35                  40                  45              


Val Pro Leu Val Ala Leu Ser Leu Pro Ser Gly Lys Phe Ser Asp Asp 
    50                  55                  60                  


Glu Ile Ile Ala Phe Leu Asn Asn Gly Val Ser Ser Leu Phe Ile Ala 
65                  70                  75                  80  


Ser Gln Asp Ala Lys Thr Ala Glu His Leu Val Glu Gln Leu Asn Val 
                85                  90                  95      


Pro Lys Glu Arg Val Val Val Glu Glu Asn Gly Val Phe Ser Asn Gln 
            100                 105                 110         


Phe Met Val Lys Gln Lys Phe Ser Gln Asp Lys Ile Val Ser Ile Lys 
        115                 120                 125             


Lys Leu Ser Lys Asp Met Leu Thr Lys Glu Val Leu Gly Glu Val Arg 
    130                 135                 140                 


Thr Asp Arg Pro Asp Gly Leu Tyr Thr Thr Leu Val Val Asp Gln Tyr 
145                 150                 155                 160 


Glu Arg Cys Leu Gly Leu Val Tyr Ser Ser Lys Lys Ser Ile Ala Lys 
                165                 170                 175     


Ala Ile Asp Leu Gly Arg Gly Val Tyr Tyr Ser Arg Ser Arg Asn Glu 
            180                 185                 190         


Ile Trp Ile Lys Gly Glu Thr Ser Gly Asn Gly Gln Lys Leu Leu Gln 
        195                 200                 205             


Ile Ser Thr Asp Cys Asp Ser Asp Ala Leu Lys Phe Ile Val Glu Gln 
    210                 215                 220                 


Glu Asn Val Gly Phe Cys His Leu Glu Thr Met Ser Cys Phe Gly Glu 
225                 230                 235                 240 


Phe Lys His Gly Leu Val Gly Leu Glu Ser Leu Leu Lys Gln Arg Leu 
                245                 250                 255     


Gln Asp Ala Pro Glu Glu Ser Tyr Thr Arg Arg Leu Phe Asn Asp Ser 
            260                 265                 270         


Ala Leu Leu Asp Ala Lys Ile Lys Glu Glu Ala Glu Glu Leu Thr Glu 
        275                 280                 285             


Ala Lys Gly Lys Lys Glu Leu Ser Trp Glu Ala Ala Asp Leu Phe Tyr 
    290                 295                 300                 


Phe Ala Leu Ala Lys Leu Val Ala Asn Asp Val Ser Leu Lys Asp Val 
305                 310                 315                 320 


Glu Asn Asn Leu Asn Met Lys His Leu Lys Val Thr Arg Arg Lys Gly 
                325                 330                 335     


Asp Ala Lys Pro Lys Phe Val Gly Gln Pro Lys Ala Glu Glu Glu Lys 
            340                 345                 350         


Leu Thr Gly Pro Ile His Leu Asp Val Val Lys Ala Ser Asp Lys Val 
        355                 360                 365             


Gly Val Gln Lys Ala Leu Ser Arg Pro Ile Gln Lys Thr Ser Glu Ile 
    370                 375                 380                 


Met His Leu Val Asn Pro Ile Ile Glu Asn Val Arg Asp Lys Gly Asn 
385                 390                 395                 400 


Ser Ala Leu Leu Glu Tyr Thr Glu Lys Phe Asp Gly Val Lys Leu Ser 
                405                 410                 415     


Asn Pro Val Leu Asn Ala Pro Phe Pro Glu Glu Tyr Phe Glu Gly Leu 
            420                 425                 430         


Thr Glu Glu Met Lys Glu Ala Leu Asp Leu Ser Ile Glu Asn Val Arg 
        435                 440                 445             


Lys Phe His Ala Ala Gln Leu Pro Thr Glu Thr Leu Glu Val Glu Thr 
    450                 455                 460                 


Gln Pro Gly Val Leu Cys Ser Arg Phe Pro Arg Pro Ile Glu Lys Val 
465                 470                 475                 480 


Gly Leu Tyr Ile Pro Gly Gly Thr Ala Ile Leu Pro Ser Thr Ala Leu 
                485                 490                 495     


Met Leu Gly Val Pro Ala Gln Val Ala Gln Cys Lys Glu Ile Val Phe 
            500                 505                 510         


Ala Ser Pro Pro Arg Lys Ser Asp Gly Lys Val Ser Pro Glu Val Val 
        515                 520                 525             


Tyr Val Ala Glu Lys Val Gly Ala Ser Lys Ile Val Leu Ala Gly Gly 
    530                 535                 540                 


Ala Gln Ala Val Ala Ala Met Ala Tyr Gly Thr Glu Thr Ile Pro Lys 
545                 550                 555                 560 


Val Asp Lys Ile Leu Gly Pro Gly Asn Gln Phe Val Thr Ala Ala Lys 
                565                 570                 575     


Met Tyr Val Gln Asn Asp Thr Gln Ala Leu Cys Ser Ile Asp Met Pro 
            580                 585                 590         


Ala Gly Pro Ser Glu Val Leu Val Ile Ala Asp Glu Asp Ala Asp Val 
        595                 600                 605             


Asp Phe Val Ala Ser Asp Leu Leu Ser Gln Ala Glu His Gly Ile Asp 
    610                 615                 620                 


Ser Gln Val Ile Leu Val Gly Val Asn Leu Ser Glu Lys Lys Ile Gln 
625                 630                 635                 640 


Glu Ile Gln Asp Ala Val His Asn Gln Ala Leu Gln Leu Pro Arg Val 
                645                 650                 655     


Asp Ile Val Arg Lys Cys Ile Ala His Ser Thr Ile Val Leu Cys Asp 
            660                 665                 670         


Gly Tyr Glu Glu Ala Leu Glu Met Ser Asn Gln Tyr Ala Pro Glu His 
        675                 680                 685             


Leu Ile Leu Gln Ile Ala Asn Ala Asn Asp Tyr Val Lys Leu Val Asp 
    690                 695                 700                 


Asn Ala Gly Ser Val Phe Val Gly Ala Tyr Thr Pro Glu Ser Cys Gly 
705                 710                 715                 720 


Asp Tyr Ser Ser Gly Thr Asn His Thr Leu Pro Thr Tyr Gly Tyr Ala 
                725                 730                 735     


Arg Gln Tyr Ser Gly Ala Asn Thr Ala Thr Phe Gln Lys Phe Ile Thr 
            740                 745                 750         


Ala Gln Asn Ile Thr Pro Glu Gly Leu Glu Asn Ile Gly Arg Ala Val 
        755                 760                 765             


Met Cys Val Ala Lys Lys Glu Gly Leu Asp Gly His Arg Asn Ala Val 
    770                 775                 780                 


Lys Ile Arg Met Ser Lys Leu Gly Leu Ile Pro Lys Asp Phe Gln 
785                 790                 795                 


<210>  48
<211>  2400
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  48
atggttttgc cgattctacc gttaattgat gatctggcct catggaatag taagaaggaa       60

tacgtttcac ttgttggtca ggtacttttg gatggctcga gcctgagtaa tgaagagatt      120

ctccagttct ccaaagagga agaagttcca ttggtggctt tgtccttgcc aagtggtaaa      180

ttcagcgatg atgaaatcat tgccttcttg aacaacggag tttcttctct gttcattgct      240

agccaagatg ctaaaacagc cgaacacttg gttgaacaat tgaatgtacc aaaggagcgt      300

gttgttgtgg aagagaacgg tgttttctcc aatcaattca tggtaaaaca aaaattctcg      360

caagataaaa ttgtgtccat aaagaaatta agcaaggata tgttgaccaa agaagtgctt      420

ggtgaagtac gtacagaccg tcctgacggt ttatatacca ccctagttgt cgaccaatat      480

gagcgttgtc tagggttggt gtattcttcg aagaaatcta tagcaaaggc catcgatttg      540

ggtcgtggcg tttattattc tcgttctagg aatgaaatct ggatcaaggg tgaaacttct      600

ggcaatggcc aaaagctttt acaaatctct actgactgtg attcggatgc cttaaagttt      660

atcgttgaac aagaaaacgt tggattttgc cacttggaga ccatgtcttg ctttggtgaa      720

ttcaagcatg gtttggtggg gctagaatct ttactaaaac aaaggctaca ggacgctcca      780

gaggaatctt atactagaag actattcaac gactctgcat tgttagatgc caagatcaag      840

gaagaagctg aagaactgac tgaggcaaag ggtaagaagg agctttcttg ggaggctgcc      900

gatttgttct actttgcact ggccaaatta gtggccaacg atgtttcatt gaaggacgtc      960

gagaataatc tgaatatgaa gcatctgaag gttacaagac ggaaaggtga tgctaagcca     1020

aagtttgttg gacaaccaaa ggctgaagaa gaaaaactga ccggtccaat tcacttggac     1080

gtggtgaagg cttccgacaa agttggtgtg cagaaggctt tgagcagacc aatccaaaag     1140

acttctgaaa ttatgcattt agtcaatccg atcatcgaaa atgttagaga caaaggtaac     1200

tctgcccttt tggagtacac agaaaagttt gatggtgtaa aattatccaa tcctgttctt     1260

aatgctccat tcccagaaga atactttgaa ggtttaaccg aggaaatgaa ggaagctttg     1320

gacctttcaa ttgaaaacgt ccgcaaattc catgctgctc aattgccaac agagactctt     1380

gaagttgaaa cccaacctgg tgtcttgtgt tccagattcc ctcgtcctat tgaaaaagtt     1440

ggtttgtata tccctggtgg cactgccatt ttaccaagta ctgcattaat gcttggtgtt     1500

ccagcacaag ttgcccaatg taaggagatt gtgtttgcat ctccaccaag aaaatctgat     1560

ggtaaagttt cacccgaagt tgtttatgtc gcagaaaaag ttggcgcttc caagattgtt     1620

ctagctggtg gtgcccaagc cgttgctgct atggcttacg ggacagaaac tattcctaaa     1680

gtggataaga tcttgggtcc aggtaatcaa tttgtgactg ccgccaaaat gtatgttcaa     1740

aatgacactc aagctctatg ttccattgat atgccagctg gcccaagtga agttttggtt     1800

attgccgatg aagatgccga tgtggatttt gttgcaagtg atttgctatc gcaagctgaa     1860

cacggtattg actcccaagt tatccttgtt ggtgttaact tgagcgaaaa gaaaattcaa     1920

gagattcaag atgctgtcca caatcaagct ttacaactgc cacgtgtgga tattgttcgt     1980

aaatgtattg ctcacagtac gatcgttctt tgtgacggtt acgaagaagc ccttgaaatg     2040

tccaaccaat atgcaccaga acatttgatt ctacaaatcg ccaatgctaa cgattatgtt     2100

aaattggttg acaatgcagg gtccgtattt gtgggtgctt acactccaga atcgtgcggt     2160

gactattcaa gtggtactaa ccatacatta ccaacctatg gttacgctag gcagtacagt     2220

ggtgccaaca ctgcaacctt ccaaaagttt atcactgccc aaaacattac ccctgaaggt     2280

ttagaaaaca tcggtagagc tgttatgtgc gttgccaaga aggagggtct agacggtcac     2340

agaaacgctg tgaaaatcag aatgagtaag cttgggttga tcccaaagga tttccagtag     2400


<210>  49
<211>  1054
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  49

Met Pro Pro Leu Phe Lys Gly Leu Lys Gln Met Ala Lys Pro Ile Ala 
1               5                   10                  15      


Tyr Val Ser Arg Phe Ser Ala Lys Arg Pro Ile His Ile Ile Leu Phe 
            20                  25                  30          


Ser Leu Ile Ile Ser Ala Phe Ala Tyr Leu Ser Val Ile Gln Tyr Tyr 
        35                  40                  45              


Phe Asn Gly Trp Gln Leu Asp Ser Asn Ser Val Phe Glu Thr Ala Pro 
    50                  55                  60                  


Asn Lys Asp Ser Asn Thr Leu Phe Gln Glu Cys Ser His Tyr Tyr Arg 
65                  70                  75                  80  


Asp Ser Ser Leu Asp Gly Trp Val Ser Ile Thr Ala His Glu Ala Ser 
                85                  90                  95      


Glu Leu Pro Ala Pro His His Tyr Tyr Leu Leu Asn Leu Asn Phe Asn 
            100                 105                 110         


Ser Pro Asn Glu Thr Asp Ser Ile Pro Glu Leu Ala Asn Thr Val Phe 
        115                 120                 125             


Glu Lys Asp Asn Thr Lys Tyr Ile Leu Gln Glu Asp Leu Ser Val Ser 
    130                 135                 140                 


Lys Glu Ile Ser Ser Thr Asp Gly Thr Lys Trp Arg Leu Arg Ser Asp 
145                 150                 155                 160 


Arg Lys Ser Leu Phe Asp Val Lys Thr Leu Ala Tyr Ser Leu Tyr Asp 
                165                 170                 175     


Val Phe Ser Glu Asn Val Thr Gln Ala Asp Pro Phe Asp Val Leu Ile 
            180                 185                 190         


Met Val Thr Ala Tyr Leu Met Met Phe Tyr Thr Ile Phe Gly Leu Phe 
        195                 200                 205             


Asn Asp Met Arg Lys Thr Gly Ser Asn Phe Trp Leu Ser Ala Ser Thr 
    210                 215                 220                 


Val Val Asn Ser Ala Ser Ser Leu Phe Leu Ala Leu Tyr Val Thr Gln 
225                 230                 235                 240 


Cys Ile Leu Gly Lys Glu Val Ser Ala Leu Thr Leu Phe Glu Gly Leu 
                245                 250                 255     


Pro Phe Ile Val Val Val Val Gly Phe Lys His Lys Ile Lys Ile Ala 
            260                 265                 270         


Gln Tyr Ala Leu Glu Lys Phe Glu Arg Val Gly Leu Ser Lys Arg Ile 
        275                 280                 285             


Thr Thr Asp Glu Ile Val Phe Glu Ser Val Ser Glu Glu Gly Gly Arg 
    290                 295                 300                 


Leu Ile Gln Asp His Leu Leu Cys Ile Phe Ala Phe Ile Gly Cys Ser 
305                 310                 315                 320 


Met Tyr Ala His Gln Leu Lys Thr Leu Thr Asn Phe Cys Ile Leu Ser 
                325                 330                 335     


Ala Phe Ile Leu Ile Phe Glu Leu Ile Leu Thr Pro Thr Phe Tyr Ser 
            340                 345                 350         


Ala Ile Leu Ala Leu Arg Leu Glu Met Asn Val Ile His Arg Ser Thr 
        355                 360                 365             


Ile Ile Lys Gln Thr Leu Glu Glu Asp Gly Val Val Pro Ser Thr Ala 
    370                 375                 380                 


Arg Ile Ile Ser Lys Ala Glu Lys Lys Ser Val Ser Ser Phe Leu Asn 
385                 390                 395                 400 


Leu Ser Val Val Val Ile Ile Met Lys Leu Ser Val Ile Leu Leu Phe 
                405                 410                 415     


Val Phe Ile Asn Phe Tyr Asn Phe Gly Ala Asn Trp Val Asn Asp Ala 
            420                 425                 430         


Phe Asn Ser Leu Tyr Phe Asp Lys Glu Arg Val Ser Leu Pro Asp Phe 
        435                 440                 445             


Ile Thr Ser Asn Ala Ser Glu Asn Phe Lys Glu Gln Ala Ile Val Ser 
    450                 455                 460                 


Val Thr Pro Leu Leu Tyr Tyr Lys Pro Ile Lys Ser Tyr Gln Arg Ile 
465                 470                 475                 480 


Glu Asp Met Val Leu Leu Leu Leu Arg Asn Val Ser Val Ala Ile Arg 
                485                 490                 495     


Asp Arg Phe Val Ser Lys Leu Val Leu Ser Ala Leu Val Cys Ser Ala 
            500                 505                 510         


Val Ile Asn Val Tyr Leu Leu Asn Ala Ala Arg Ile His Thr Ser Tyr 
        515                 520                 525             


Thr Ala Asp Gln Leu Val Lys Thr Glu Val Thr Lys Lys Ser Phe Thr 
    530                 535                 540                 


Ala Pro Val Gln Lys Ala Ser Thr Pro Val Leu Thr Asn Lys Thr Val 
545                 550                 555                 560 


Ile Ser Gly Ser Lys Val Lys Ser Leu Ser Ser Ala Gln Ser Ser Ser 
                565                 570                 575     


Ser Gly Pro Ser Ser Ser Ser Glu Glu Asp Asp Ser Arg Asp Ile Glu 
            580                 585                 590         


Ser Leu Asp Lys Lys Ile Arg Pro Leu Glu Glu Leu Glu Ala Leu Leu 
        595                 600                 605             


Ser Ser Gly Asn Thr Lys Gln Leu Lys Asn Lys Glu Val Ala Ala Leu 
    610                 615                 620                 


Val Ile His Gly Lys Leu Pro Leu Tyr Ala Leu Glu Lys Lys Leu Gly 
625                 630                 635                 640 


Asp Thr Thr Arg Ala Val Ala Val Arg Arg Lys Ala Leu Ser Ile Leu 
                645                 650                 655     


Ala Glu Ala Pro Val Leu Ala Ser Asp Arg Leu Pro Tyr Lys Asn Tyr 
            660                 665                 670         


Asp Tyr Asp Arg Val Phe Gly Ala Cys Cys Glu Asn Val Ile Gly Tyr 
        675                 680                 685             


Met Pro Leu Pro Val Gly Val Ile Gly Pro Leu Val Ile Asp Gly Thr 
    690                 695                 700                 


Ser Tyr His Ile Pro Met Ala Thr Thr Glu Gly Cys Leu Val Ala Ser 
705                 710                 715                 720 


Ala Met Arg Gly Cys Lys Ala Ile Asn Ala Gly Gly Gly Ala Thr Thr 
                725                 730                 735     


Val Leu Thr Lys Asp Gly Met Thr Arg Gly Pro Val Val Arg Phe Pro 
            740                 745                 750         


Thr Leu Lys Arg Ser Gly Ala Cys Lys Ile Trp Leu Asp Ser Glu Glu 
        755                 760                 765             


Gly Gln Asn Ala Ile Lys Lys Ala Phe Asn Ser Thr Ser Arg Phe Ala 
    770                 775                 780                 


Arg Leu Gln His Ile Gln Thr Cys Leu Ala Gly Asp Leu Leu Phe Met 
785                 790                 795                 800 


Arg Phe Arg Thr Thr Thr Gly Asp Ala Met Gly Met Asn Met Ile Ser 
                805                 810                 815     


Lys Gly Val Glu Tyr Ser Leu Lys Gln Met Val Glu Glu Tyr Gly Trp 
            820                 825                 830         


Glu Asp Met Glu Val Val Ser Val Ser Gly Asn Tyr Cys Thr Asp Lys 
        835                 840                 845             


Lys Pro Ala Ala Ile Asn Trp Ile Glu Gly Arg Gly Lys Ser Val Val 
    850                 855                 860                 


Ala Glu Ala Thr Ile Pro Gly Asp Val Val Arg Lys Val Leu Lys Ser 
865                 870                 875                 880 


Asp Val Ser Ala Leu Val Glu Leu Asn Ile Ala Lys Asn Leu Val Gly 
                885                 890                 895     


Ser Ala Met Ala Gly Ser Val Gly Gly Phe Asn Ala His Ala Ala Asn 
            900                 905                 910         


Leu Val Thr Ala Val Phe Leu Ala Leu Gly Gln Asp Pro Ala Gln Asn 
        915                 920                 925             


Val Glu Ser Ser Asn Cys Ile Thr Leu Met Lys Glu Val Asp Gly Asp 
    930                 935                 940                 


Leu Arg Ile Ser Val Ser Met Pro Ser Ile Glu Val Gly Thr Ile Gly 
945                 950                 955                 960 


Gly Gly Thr Val Leu Glu Pro Gln Gly Ala Met Leu Asp Leu Leu Gly 
                965                 970                 975     


Val Arg Gly Pro His Ala Thr Ala Pro Gly Thr Asn Ala Arg Gln Leu 
            980                 985                 990         


Ala Arg Ile Val Ala Cys Ala Val  Leu Ala Gly Glu Leu  Ser Leu Cys 
        995                 1000                 1005             


Ala Ala  Leu Ala Ala Gly His  Leu Val Gln Ser His  Met Thr His 
    1010                 1015                 1020             


Asn Arg  Lys Pro Ala Glu Pro  Thr Lys Pro Asn Asn  Leu Asp Ala 
    1025                 1030                 1035             


Thr Asp  Ile Asn Arg Leu Lys  Asp Gly Ser Val Thr  Cys Ile Lys 
    1040                 1045                 1050             


Ser 
    


<210>  50
<211>  3165
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  50
atgccgccgc tattcaaggg actgaaacag atggcaaagc caattgccta tgtttcaaga       60

ttttcggcga aacgaccaat tcatataata cttttttctc taatcatatc cgcattcgct      120

tatctatccg tcattcagta ttacttcaat ggttggcaac tagattcaaa tagtgttttt      180

gaaactgctc caaataaaga ctccaacact ctatttcaag aatgttccca ttactacaga      240

gattcctctc tagatggttg ggtatcaatc accgcgcatg aagctagtga gttaccagcc      300

ccacaccatt actatctatt aaacctgaac ttcaatagtc ctaatgaaac tgactccatt      360

ccagaactag ctaacacggt ttttgagaaa gataatacaa aatatattct gcaagaagat      420

ctcagtgttt ccaaagaaat ttcttctact gatggaacga aatggaggtt aagaagtgac      480

agaaaaagtc ttttcgacgt aaagacgtta gcatattctc tctacgatgt attttcagaa      540

aatgtaaccc aagcagaccc gtttgacgtc cttattatgg ttactgccta cctaatgatg      600

ttctacacca tattcggcct cttcaatgac atgaggaaga ccgggtcaaa tttttggttg      660

agcgcctcta cagtggtcaa ttctgcatca tcacttttct tagcattgta tgtcacccaa      720

tgtattctag gcaaagaagt ttccgcatta actctttttg aaggtttgcc tttcattgta      780

gttgttgttg gtttcaagca caaaatcaag attgcccagt atgccctgga gaaatttgaa      840

agagtcggtt tatctaaaag gattactacc gatgaaatcg tttttgaatc cgtgagcgaa      900

gagggtggtc gtttgattca agaccatttg ctttgtattt ttgcctttat cggatgctct      960

atgtatgctc accaattgaa gactttgaca aacttctgca tattatcagc atttatccta     1020

atttttgaat tgattttaac tcctacattt tattctgcta tcttagcgct tagactggaa     1080

atgaatgtta tccacagatc tactattatc aagcaaacat tagaagaaga cggtgttgtt     1140

ccatctacag caagaatcat ttctaaagca gaaaagaaat ccgtatcttc tttcttaaat     1200

ctcagtgtgg ttgtcattat catgaaactc tctgtcatac tgttgtttgt cttcatcaac     1260

ttttataact ttggtgcaaa ttgggtcaat gatgccttca attcattgta cttcgataag     1320

gaacgtgttt ctctaccaga ttttattacc tcgaatgcct ctgaaaactt taaagagcaa     1380

gctattgtta gtgtcacccc attattatat tacaaaccca ttaagtccta ccaacgcatt     1440

gaggatatgg ttcttctatt gcttcgtaat gtcagtgttg ccattcgtga taggttcgtc     1500

agtaaattag ttctttccgc cttagtatgc agtgctgtca tcaatgtgta tttattgaat     1560

gctgctagaa ttcataccag ttatactgca gaccaattgg tgaaaactga agtcaccaag     1620

aagtctttta ctgctcctgt acaaaaggct tctacaccag ttttaaccaa taaaacagtc     1680

atttctggat cgaaagtcaa aagtttatca tctgcgcaat cgagctcatc aggaccttca     1740

tcatctagtg aggaagatga ttcccgcgat attgaaagct tggataagaa aatacgtcct     1800

ttagaagaat tagaagcatt attaagtagt ggaaatacaa aacaattgaa gaacaaagag     1860

gtcgctgcct tggttattca cggtaagtta cctttgtacg ctttggagaa aaaattaggt     1920

gatactacga gagcggttgc ggtacgtagg aaggctcttt caattttggc agaagctcct     1980

gtattagcat ctgatcgttt accatataaa aattatgact acgaccgcgt atttggcgct     2040

tgttgtgaaa atgttatagg ttacatgcct ttgcccgttg gtgttatagg ccccttggtt     2100

atcgatggta catcttatca tataccaatg gcaactacag agggttgttt ggtagcttct     2160

gccatgcgtg gctgtaaggc aatcaatgct ggcggtggtg caacaactgt tttaactaag     2220

gatggtatga caagaggccc agtagtccgt ttcccaactt tgaaaagatc tggtgcctgt     2280

aagatatggt tagactcaga agagggacaa aacgcaatta aaaaagcttt taactctaca     2340

tcaagatttg cacgtctgca acatattcaa acttgtctag caggagattt actcttcatg     2400

agatttagaa caactactgg tgacgcaatg ggtatgaata tgatttctaa aggtgtcgaa     2460

tactcattaa agcaaatggt agaagagtat ggctgggaag atatggaggt tgtctccgtt     2520

tctggtaact actgtaccga caaaaaacca gctgccatca actggatcga aggtcgtggt     2580

aagagtgtcg tcgcagaagc tactattcct ggtgatgttg tcagaaaagt gttaaaaagt     2640

gatgtttccg cattggttga gttgaacatt gctaagaatt tggttggatc tgcaatggct     2700

gggtctgttg gtggatttaa cgcacatgca gctaatttag tgacagctgt tttcttggca     2760

ttaggacaag atcctgcaca aaatgttgaa agttccaact gtataacatt gatgaaagaa     2820

gtggacggtg atttgagaat ttccgtatcc atgccatcca tcgaagtagg taccatcggt     2880

ggtggtactg ttctagaacc acaaggtgcc atgttggact tattaggtgt aagaggcccg     2940

catgctaccg ctcctggtac caacgcacgt caattagcaa gaatagttgc ctgtgccgtc     3000

ttggcaggtg aattatcctt atgtgctgcc ctagcagccg gccatttggt tcaaagtcat     3060

atgacccaca acaggaaacc tgctgaacca acaaaaccta acaatttgga cgccactgat     3120

ataaatcgtt tgaaagatgg gtccgtcacc tgcattaaat cctaa                     3165


<210>  51
<211>  428
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  51

Met Ser Met Leu Ser Arg Arg Leu Phe Ser Thr Ser Arg Leu Ala Ala 
1               5                   10                  15      


Phe Ser Lys Ile Lys Val Lys Gln Pro Val Val Glu Leu Asp Gly Asp 
            20                  25                  30          


Glu Met Thr Arg Ile Ile Trp Asp Lys Ile Lys Lys Lys Leu Ile Leu 
        35                  40                  45              


Pro Tyr Leu Asp Val Asp Leu Lys Tyr Tyr Asp Leu Ser Val Glu Ser 
    50                  55                  60                  


Arg Asp Ala Thr Ser Asp Lys Ile Thr Gln Asp Ala Ala Glu Ala Ile 
65                  70                  75                  80  


Lys Lys Tyr Gly Val Gly Ile Lys Cys Ala Thr Ile Thr Pro Asp Glu 
                85                  90                  95      


Ala Arg Val Lys Glu Phe Asn Leu His Lys Met Trp Lys Ser Pro Asn 
            100                 105                 110         


Gly Thr Ile Arg Asn Ile Leu Gly Gly Thr Val Phe Arg Glu Pro Ile 
        115                 120                 125             


Val Ile Pro Arg Ile Pro Arg Leu Val Pro Arg Trp Glu Lys Pro Ile 
    130                 135                 140                 


Ile Ile Gly Arg His Ala His Gly Asp Gln Tyr Lys Ala Thr Asp Thr 
145                 150                 155                 160 


Leu Ile Pro Gly Pro Gly Ser Leu Glu Leu Val Tyr Lys Pro Ser Asp 
                165                 170                 175     


Pro Thr Thr Ala Gln Pro Gln Thr Leu Lys Val Tyr Asp Tyr Lys Gly 
            180                 185                 190         


Ser Gly Val Ala Met Ala Met Tyr Asn Thr Asp Glu Ser Ile Glu Gly 
        195                 200                 205             


Phe Ala His Ser Ser Phe Lys Leu Ala Ile Asp Lys Lys Leu Asn Leu 
    210                 215                 220                 


Phe Leu Ser Thr Lys Asn Thr Ile Leu Lys Lys Tyr Asp Gly Arg Phe 
225                 230                 235                 240 


Lys Asp Ile Phe Gln Glu Val Tyr Glu Ala Gln Tyr Lys Ser Lys Phe 
                245                 250                 255     


Glu Gln Leu Gly Ile His Tyr Glu His Arg Leu Ile Asp Asp Met Val 
            260                 265                 270         


Ala Gln Met Ile Lys Ser Lys Gly Gly Phe Ile Met Ala Leu Lys Asn 
        275                 280                 285             


Tyr Asp Gly Asp Val Gln Ser Asp Ile Val Ala Gln Gly Phe Gly Ser 
    290                 295                 300                 


Leu Gly Leu Met Thr Ser Ile Leu Val Thr Pro Asp Gly Lys Thr Phe 
305                 310                 315                 320 


Glu Ser Glu Ala Ala His Gly Thr Val Thr Arg His Tyr Arg Lys Tyr 
                325                 330                 335     


Gln Lys Gly Glu Glu Thr Ser Thr Asn Ser Ile Ala Ser Ile Phe Ala 
            340                 345                 350         


Trp Ser Arg Gly Leu Leu Lys Arg Gly Glu Leu Asp Asn Thr Pro Ala 
        355                 360                 365             


Leu Cys Lys Phe Ala Asn Ile Leu Glu Ser Ala Thr Leu Asn Thr Val 
    370                 375                 380                 


Gln Gln Asp Gly Ile Met Thr Lys Asp Leu Ala Leu Ala Cys Gly Asn 
385                 390                 395                 400 


Asn Glu Arg Ser Ala Tyr Val Thr Thr Glu Glu Phe Leu Asp Ala Val 
                405                 410                 415     


Glu Lys Arg Leu Gln Lys Glu Ile Lys Ser Ile Glu 
            420                 425             


<210>  52
<211>  1287
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  52
atgagtatgt tatctagaag attattttcc acctctcgcc ttgctgcttt cagtaagatt       60

aaggtcaaac aacccgttgt cgagttggac ggtgatgaaa tgacccgtat catttgggat      120

aagatcaaga agaaattgat tctaccctac ttggacgtag atttgaagta ctacgactta      180

tctgtcgaat ctcgtgacgc cacctccgac aagattactc aggatgctgc tgaggcgatc      240

aagaagtatg gtgttggtat caaatgtgcc accatcactc ctgatgaagc tcgtgtgaag      300

gaattcaacc tgcacaagat gtggaaatct cctaatggta ccatcagaaa cattctcggc      360

ggtacagtgt tcagagagcc cattgtgatt cctagaattc ctagactggt cccacgttgg      420

gaaaaaccaa tcattattgg aagacacgcc cacggtgatc aatataaagc tacggacaca      480

ctgatcccag gcccaggatc tttggaactg gtctacaagc catccgaccc tacgactgct      540

caaccacaaa ctttgaaagt gtatgactac aagggcagtg gtgtggccat ggccatgtac      600

aatactgacg aatccatcga agggtttgct cattcgtctt tcaagctggc cattgacaaa      660

aagctaaatc ttttcttgtc aaccaagaac actattttga agaaatatga cggtcggttc      720

aaagacattt tccaagaagt ttatgaagct caatataaat ccaaattcga acaactaggg      780

atccactatg aacaccgttt aattgatgat atggtcgctc aaatgataaa atctaaaggt      840

ggctttatca tggcgctaaa gaactatgac ggtgatgtcc aatctgacat cgtcgctcaa      900

ggatttggct ccttaggttt gatgacttct atcttagtta caccagacgg taaaactttc      960

gaaagtgaag ctgctcatgg taccgtgaca agacattata gaaagtacca aaagggtgaa     1020

gaaacttcta caaactccat tgcatccatt ttcgcgtggt cgagaggtct attgaagaga     1080

ggtgaattgg acaatactcc tgctttgtgt aaatttgcca atattttgga atccgccact     1140

ttgaacacag ttcagcaaga cggtatcatg acgaaggact tggctttggc ttgcggtaac     1200

aacgaaagat ctgcttatgt taccacagaa gaatttttgg atgccgttga aaaaagacta     1260

caaaaagaaa tcaagtcgat cgagtaa                                         1287


<210>  53
<211>  371
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  53

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu Arg Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val Arg Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  54
<211>  1116
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  54
atgtttagat ctgttgctac tagattatct gcctgccgtg ggttagcatc taacgctgct       60

cgcaaatcac tcactattgg tcttatcccc ggtgacggta tcggtaagga agtcattcct      120

gctggtaagc aagttttgga aaaccttaac tccaagcacg gcctaagctt caactttatt      180

gatctctacg ccggtttcca aacattccaa gaaacaggaa aggcgttgcc tgatgagact      240

gttaaagtgt tgaaggaaca atgtcaaggt gctcttttcg gtgcagttca gtctccaact      300

actaaggtgg aaggttactc ctcaccaatt gttgctctaa ggagggaaat gggccttttc      360

gctaatgttc gtcctgttaa gtctgtagag ggagaaaagg gtaaaccaat tgacatggtt      420

atcgtcagag aaaatactga ggacctgtac attaaaattg aaaaaacata cattgacaag      480

gccacaggta caagagttgc tgatgccaca aagagaatat ccgaaattgc aacaagaaga      540

attgcaacca ttgcattaga tattgccttg aaaagattac aaacaagagg ccaagccact      600

ttgacagtga ctcataaatc aaatgttcta tctcaaagtg atggtctatt cagagaaatc      660

tgtaaggaag tctacgaatc taacaaggac aagtacggtc aaatcaaata taacgaacaa      720

attgtggatt ccatggttta taggctgttc agagaaccac aatgttttga tgtgatagtg      780

gcaccaaacc tatacgggga tatattatct gacggtgctg ctgctttagt cggttcatta      840

ggtgttgttc caagcgccaa cgtaggtcca gaaattgtca ttggtgaacc atgccatggt      900

tctgcaccag atattgctgg taaaggtatt gctaacccaa tcgccactat aagatctact      960

gctttgatgt tggaattctt gggccacaac gaagctgccc aagatatcta caaggctgtt     1020

gatgctaact taagagaggg ttctatcaag acaccagatt taggtggtaa ggcttctact     1080

caacaagtcg ttgacgacgt tttgtcgaga ttatag                               1116


<210>  55
<211>  469
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  55

Met Ser Tyr Ser Ala Ala Asp Asn Leu Gln Asp Ser Phe Gln Arg Ala 
1               5                   10                  15      


Met Asn Phe Ser Gly Ser Pro Gly Ala Val Ser Thr Ser Pro Thr Gln 
            20                  25                  30          


Ser Phe Met Asn Thr Leu Pro Arg Arg Val Ser Ile Thr Lys Gln Pro 
        35                  40                  45              


Lys Ala Leu Lys Pro Phe Ser Thr Gly Asp Met Asn Ile Leu Leu Leu 
    50                  55                  60                  


Glu Asn Val Asn Ala Thr Ala Ile Lys Ile Phe Lys Asp Gln Gly Tyr 
65                  70                  75                  80  


Gln Val Glu Phe His Lys Ser Ser Leu Pro Glu Asp Glu Leu Ile Glu 
                85                  90                  95      


Lys Ile Lys Asp Val His Ala Ile Gly Ile Arg Ser Lys Thr Arg Leu 
            100                 105                 110         


Thr Glu Lys Ile Leu Gln His Ala Arg Asn Leu Val Cys Ile Gly Cys 
        115                 120                 125             


Phe Cys Ile Gly Thr Asn Gln Val Asp Leu Lys Tyr Ala Ala Ser Lys 
    130                 135                 140                 


Gly Ile Ala Val Phe Asn Ser Pro Phe Ser Asn Ser Arg Ser Val Ala 
145                 150                 155                 160 


Glu Leu Val Ile Gly Glu Ile Ile Ser Leu Ala Arg Gln Leu Gly Asp 
                165                 170                 175     


Arg Ser Ile Glu Leu His Thr Gly Thr Trp Asn Lys Val Ala Ala Arg 
            180                 185                 190         


Cys Trp Glu Val Arg Gly Lys Thr Leu Gly Ile Ile Gly Tyr Gly His 
        195                 200                 205             


Ile Gly Ser Gln Leu Ser Val Leu Ala Glu Ala Met Gly Leu His Val 
    210                 215                 220                 


Leu Tyr Tyr Asp Ile Val Thr Ile Met Ala Leu Gly Thr Ala Arg Gln 
225                 230                 235                 240 


Val Ser Thr Leu Asp Glu Leu Leu Asn Lys Ser Asp Phe Val Thr Leu 
                245                 250                 255     


His Val Pro Ala Thr Pro Glu Thr Glu Lys Met Leu Ser Ala Pro Gln 
            260                 265                 270         


Phe Ala Ala Met Lys Asp Gly Ala Tyr Val Ile Asn Ala Ser Arg Gly 
        275                 280                 285             


Thr Val Val Asp Ile Pro Ser Leu Ile Gln Ala Val Lys Ala Asn Lys 
    290                 295                 300                 


Ile Ala Gly Ala Ala Leu Asp Val Tyr Pro His Glu Pro Ala Lys Asn 
305                 310                 315                 320 


Gly Glu Gly Ser Phe Asn Asp Glu Leu Asn Ser Trp Thr Ser Glu Leu 
                325                 330                 335     


Val Ser Leu Pro Asn Ile Ile Leu Thr Pro His Ile Gly Gly Ser Thr 
            340                 345                 350         


Glu Glu Ala Gln Ser Ser Ile Gly Ile Glu Val Ala Thr Ala Leu Ser 
        355                 360                 365             


Lys Tyr Ile Asn Glu Gly Asn Ser Val Gly Ser Val Asn Phe Pro Glu 
    370                 375                 380                 


Val Ser Leu Lys Ser Leu Asp Tyr Asp Gln Glu Asn Thr Val Arg Val 
385                 390                 395                 400 


Leu Tyr Ile His Arg Asn Val Pro Gly Val Leu Lys Thr Val Asn Asp 
                405                 410                 415     


Ile Leu Ser Asp His Asn Ile Glu Lys Gln Phe Ser Asp Ser His Gly 
            420                 425                 430         


Glu Ile Ala Tyr Leu Met Ala Asp Ile Ser Ser Val Asn Gln Ser Glu 
        435                 440                 445             


Ile Lys Asp Ile Tyr Glu Lys Leu Asn Gln Thr Ser Ala Lys Val Ser 
    450                 455                 460                 


Ile Arg Leu Leu Tyr 
465                 


<210>  56
<211>  1410
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  56
atgtcttatt cagctgccga taatttacaa gattcattcc aacgtgccat gaacttttct       60

ggctctcctg gtgcagtctc aacctcacca actcagtcat ttatgaacac actacctcgt      120

cgtgtaagca ttacaaagca accaaaggct ttaaaacctt tttctactgg tgacatgaat      180

attctactgt tggaaaatgt caatgcaact gcaatcaaaa tcttcaagga tcagggttac      240

caagtagagt tccacaagtc ttctctacct gaggatgaat tgattgaaaa aatcaaagac      300

gtacacgcta tcggtataag atccaaaact agattgactg aaaaaatact acagcatgcc      360

aggaatctag tttgtattgg ttgtttttgc ataggtacca atcaagtaga cctaaaatat      420

gccgctagta aaggtattgc tgttttcaat tcgccattct ccaattcaag atccgtagca      480

gaattggtaa ttggtgagat cattagttta gcaagacaat taggtgatag atccattgaa      540

ctgcatacag gtacatggaa taaagtcgct gctaggtgtt gggaagtaag aggaaaaact      600

ctcggtatta ttgggtatgg tcacattggt tcgcaattat cagttcttgc agaagctatg      660

ggcctgcatg tgctatacta tgatatcgtg acaattatgg ccttaggtac tgccagacaa      720

gtttctacat tagatgaatt gttgaataaa tctgattttg taacactaca tgtaccagct      780

actccagaaa ctgaaaaaat gttatctgct ccacaattcg ctgctatgaa ggacggggct      840

tatgttatta atgcctcaag aggtactgtc gtggacattc catctctgat ccaagccgtc      900

aaggccaaca aaattgcagg tgctgcttta gatgtttatc cacatgaacc agctaagaac      960

ggtgaaggtt catttaacga tgaacttaac agctggactt ctgagttggt ttcattacca     1020

aatataatcc tgacaccaca tattggtggc tctacagaag aagctcaaag ttcaatcggt     1080

attgaggtgg ctactgcatt gtccaaatac atcaatgaag gtaactctgt cggttctgtg     1140

aacttcccag aagtcagttt gaagtctttg gactacgatc aagagaacac agtacgtgtc     1200

ttgtatattc atcgtaacgt tcctggtgtt ttgaagaccg ttaatgatat cttatccgat     1260

cataatatcg agaaacagtt ttctgattct cacggcgaga tcgcttatct aatggcagac     1320

atctcttctg ttaatcaaag tgaaatcaag gatatatatg aaaagttgaa ccaaacttct     1380

gccaaagttt ccatcaggtt attatactaa                                      1410


<210>  57
<211>  505
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  57

Met Ser Glu Gly Pro Val Lys Phe Glu Lys Asn Thr Val Ile Ser Val 
1               5                   10                  15      


Phe Gly Ala Ser Gly Asp Leu Ala Lys Lys Lys Thr Phe Pro Ala Leu 
            20                  25                  30          


Phe Gly Leu Phe Arg Glu Gly Tyr Leu Asp Pro Ser Thr Lys Ile Phe 
        35                  40                  45              


Gly Tyr Ala Arg Ser Lys Leu Ser Met Glu Glu Asp Leu Lys Ser Arg 
    50                  55                  60                  


Val Leu Pro His Leu Lys Lys Pro His Gly Glu Ala Asp Asp Ser Lys 
65                  70                  75                  80  


Val Glu Gln Phe Phe Lys Met Val Ser Tyr Ile Ser Gly Asn Tyr Asp 
                85                  90                  95      


Thr Asp Glu Gly Phe Asp Glu Leu Arg Thr Gln Ile Glu Lys Phe Glu 
            100                 105                 110         


Lys Ser Ala Asn Val Asp Val Pro His Arg Leu Phe Tyr Leu Ala Leu 
        115                 120                 125             


Pro Pro Ser Val Phe Leu Thr Val Ala Lys Gln Ile Lys Ser Arg Val 
    130                 135                 140                 


Tyr Ala Glu Asn Gly Ile Thr Arg Val Ile Val Glu Lys Pro Phe Gly 
145                 150                 155                 160 


His Asp Leu Ala Ser Ala Arg Glu Leu Gln Lys Asn Leu Gly Pro Leu 
                165                 170                 175     


Phe Lys Glu Glu Glu Leu Tyr Arg Ile Asp His Tyr Leu Gly Lys Glu 
            180                 185                 190         


Leu Val Lys Asn Leu Leu Val Leu Arg Phe Gly Asn Gln Phe Leu Asn 
        195                 200                 205             


Ala Ser Trp Asn Arg Asp Asn Ile Gln Ser Val Gln Ile Ser Phe Lys 
    210                 215                 220                 


Glu Arg Phe Gly Thr Glu Gly Arg Gly Gly Tyr Phe Asp Ser Ile Gly 
225                 230                 235                 240 


Ile Ile Arg Asp Val Met Gln Asn His Leu Leu Gln Ile Met Thr Leu 
                245                 250                 255     


Leu Thr Met Glu Arg Pro Val Ser Phe Asp Pro Glu Ser Ile Arg Asp 
            260                 265                 270         


Glu Lys Val Lys Val Leu Lys Ala Val Ala Pro Ile Asp Thr Asp Asp 
        275                 280                 285             


Val Leu Leu Gly Gln Tyr Gly Lys Ser Glu Asp Gly Ser Lys Pro Ala 
    290                 295                 300                 


Tyr Val Asp Asp Asp Thr Val Asp Lys Asp Ser Lys Cys Val Thr Phe 
305                 310                 315                 320 


Ala Ala Met Thr Phe Asn Ile Glu Asn Glu Arg Trp Glu Gly Val Pro 
                325                 330                 335     


Ile Met Met Arg Ala Gly Lys Ala Leu Asn Glu Ser Lys Val Glu Ile 
            340                 345                 350         


Arg Leu Gln Tyr Lys Ala Val Ala Ser Gly Val Phe Lys Asp Ile Pro 
        355                 360                 365             


Asn Asn Glu Leu Val Ile Arg Val Gln Pro Asp Ala Ala Val Tyr Leu 
    370                 375                 380                 


Lys Phe Asn Ala Lys Thr Pro Gly Leu Ser Asn Ala Thr Gln Val Thr 
385                 390                 395                 400 


Asp Leu Asn Leu Thr Tyr Ala Ser Arg Tyr Gln Asp Phe Trp Ile Pro 
                405                 410                 415     


Glu Ala Tyr Glu Val Leu Ile Arg Asp Ala Leu Leu Gly Asp His Ser 
            420                 425                 430         


Asn Phe Val Arg Asp Asp Glu Leu Asp Ile Ser Trp Gly Ile Phe Thr 
        435                 440                 445             


Pro Leu Leu Lys His Ile Glu Arg Pro Asp Gly Pro Thr Pro Glu Ile 
    450                 455                 460                 


Tyr Pro Tyr Gly Ser Arg Gly Pro Lys Gly Leu Lys Glu Tyr Met Gln 
465                 470                 475                 480 


Lys His Lys Tyr Val Met Pro Glu Lys His Pro Tyr Ala Trp Pro Val 
                485                 490                 495     


Thr Lys Pro Glu Asp Thr Lys Asp Asn 
            500                 505 


<210>  58
<211>  1518
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  58
atgagtgaag gccccgtcaa attcgaaaaa aataccgtca tatctgtctt tggtgcgtca       60

ggtgatctgg caaagaagaa gacttttccc gccttatttg ggcttttcag agaaggttac      120

cttgatccat ctaccaagat cttcggttat gcccggtcca aattgtccat ggaggaggac      180

ctgaagtccc gtgtcctacc ccacttgaaa aaacctcacg gtgaagccga tgactctaag      240

gtcgaacagt tcttcaagat ggtcagctac atttcgggaa attacgacac agatgaaggc      300

ttcgacgaat taagaacgca gatcgagaaa ttcgagaaaa gtgccaacgt cgatgtccca      360

caccgtctct tctatctggc cttgccgcca agcgtttttt tgacggtggc caagcagatc      420

aagagtcgtg tgtacgcaga gaatggcatc acccgtgtaa tcgtagagaa acctttcggc      480

cacgacctgg cctctgccag ggagctgcaa aaaaacctgg ggcccctctt taaagaagaa      540

gagttgtaca gaattgacca ttacttgggt aaagagttgg tcaagaatct tttagtcttg      600

aggttcggta accagttttt gaatgcctcg tggaatagag acaacattca aagcgttcag      660

atttcgttta aagagaggtt cggcaccgaa ggccgtggcg gctatttcga ctctataggc      720

ataatcagag acgtgatgca gaaccatctg ttacaaatca tgactctctt gactatggaa      780

agaccggtgt cttttgaccc ggaatctatt cgtgacgaaa aggttaaggt tctaaaggcc      840

gtggccccca tcgacacgga cgacgtcctc ttgggccagt acggtaaatc tgaggacggg      900

tctaagcccg cctacgtgga tgatgacact gtagacaagg actctaaatg tgtcactttt      960

gcagcaatga ctttcaacat cgaaaacgag cgttgggagg gcgtccccat catgatgcgt     1020

gccggtaagg ctttgaatga gtccaaggtg gagatcagac tgcagtacaa agcggtcgca     1080

tcgggtgtct tcaaagacat tccaaataac gaactggtca tcagagtgca gcccgatgcc     1140

gctgtgtacc taaagtttaa tgctaagacc cctggtctgt caaatgctac ccaagtcaca     1200

gatctgaatc taacttacgc aagcaggtac caagactttt ggattccaga ggcttacgag     1260

gtgttgataa gagacgccct actgggtgac cattccaact ttgtcagaga tgacgaattg     1320

gatatcagtt ggggcatatt caccccatta ctgaagcaca tagagcgtcc ggacggtcca     1380

acaccggaaa tttaccccta cggatcaaga ggtccaaagg gattgaagga atatatgcaa     1440

aaacacaagt atgttatgcc cgaaaagcac ccttacgctt ggcccgtgac taagccagaa     1500

gatacgaagg ataattag                                                   1518


<210>  59
<211>  342
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  59

Met Val Leu Val Lys Gln Val Arg Leu Gly Asn Ser Gly Leu Lys Ile 
1               5                   10                  15      


Ser Pro Ile Val Ile Gly Cys Met Ser Tyr Gly Ser Lys Lys Trp Ala 
            20                  25                  30          


Asp Trp Val Ile Glu Asp Lys Thr Gln Ile Phe Lys Ile Met Lys His 
        35                  40                  45              


Cys Tyr Asp Lys Gly Leu Arg Thr Phe Asp Thr Ala Asp Phe Tyr Ser 
    50                  55                  60                  


Asn Gly Leu Ser Glu Arg Ile Ile Lys Glu Phe Leu Glu Tyr Tyr Ser 
65                  70                  75                  80  


Ile Lys Arg Glu Thr Val Val Ile Met Thr Lys Ile Tyr Phe Pro Val 
                85                  90                  95      


Asp Glu Thr Leu Asp Leu His His Asn Phe Thr Leu Asn Glu Phe Glu 
            100                 105                 110         


Glu Leu Asp Leu Ser Asn Gln Arg Gly Leu Ser Arg Lys His Ile Ile 
        115                 120                 125             


Ala Gly Val Glu Asn Ser Val Lys Arg Leu Gly Thr Tyr Ile Asp Leu 
    130                 135                 140                 


Leu Gln Ile His Arg Leu Asp His Glu Thr Pro Met Lys Glu Ile Met 
145                 150                 155                 160 


Lys Ala Leu Asn Asp Val Val Glu Ala Gly His Val Arg Tyr Ile Gly 
                165                 170                 175     


Ala Ser Ser Met Leu Ala Thr Glu Phe Ala Glu Leu Gln Phe Thr Ala 
            180                 185                 190         


Asp Lys Tyr Gly Trp Phe Gln Phe Ile Ser Ser Gln Ser Tyr Tyr Asn 
        195                 200                 205             


Leu Leu Tyr Arg Glu Asp Glu Arg Glu Leu Ile Pro Phe Ala Lys Arg 
    210                 215                 220                 


His Asn Ile Gly Leu Leu Pro Trp Ser Pro Asn Ala Arg Gly Met Leu 
225                 230                 235                 240 


Thr Arg Pro Leu Asn Gln Ser Thr Asp Arg Ile Lys Ser Asp Pro Thr 
                245                 250                 255     


Phe Lys Ser Leu His Leu Asp Asn Leu Glu Glu Glu Gln Lys Glu Ile 
            260                 265                 270         


Ile Asn Arg Val Glu Lys Val Ser Lys Asp Lys Lys Val Ser Met Ala 
        275                 280                 285             


Met Leu Ser Ile Ala Trp Val Leu His Lys Gly Cys His Pro Ile Val 
    290                 295                 300                 


Gly Leu Asn Thr Thr Ala Arg Val Asp Glu Ala Ile Ala Ala Leu Gln 
305                 310                 315                 320 


Val Thr Leu Thr Glu Glu Glu Ile Lys Tyr Leu Glu Glu Pro Tyr Lys 
                325                 330                 335     


Pro Gln Arg Gln Arg Cys 
            340         


<210>  60
<211>  1029
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  60
atggttttag ttaagcaggt aagactcggt aactcaggtc ttaagatatc accgatagtg       60

ataggatgta tgtcatacgg gtccaagaaa tgggcggact gggtcataga ggacaagacc      120

caaattttca agattatgaa gcattgttac gataaaggtc ttcgtacttt tgacacagca      180

gatttttatt ctaatggttt gagtgaaaga ataattaagg agtttctgga gtactacagt      240

ataaagagag aaacggtggt gattatgacc aaaatttact tcccagttga tgaaacgctt      300

gatttgcatc ataacttcac tttaaatgaa tttgaagaat tggacttgtc caaccagcgg      360

ggtttatcca gaaagcatat aattgctggt gtcgagaact ctgtgaaaag actgggcaca      420

tatatagacc ttttacaaat tcacagatta gatcatgaaa cgccaatgaa agagatcatg      480

aaggcattga atgatgttgt tgaagcgggc cacgttagat acattggggc ttcgagtatg      540

ttggcaactg aatttgcaga actgcagttc acagccgata aatatggctg gtttcagttc      600

atttcttcgc agtcttacta caatttgctc tatcgtgaag atgaacgcga attgattcct      660

tttgccaaaa gacacaatat tggtttactt ccatggtctc ctaacgcacg aggcatgttg      720

actcgtcctc tgaaccaaag cacggacagg attaagagtg atccaacttt caagtcgtta      780

catttggata atctcgaaga agaacaaaag gaaattataa atcgtgtgga aaaggtgtcg      840

aaggacaaaa aagtctcgat ggctatgctc tccattgcat gggttttgca taaaggatgt      900

caccctattg tgggattgaa cactacagca agagtagacg aagcgattgc cgcactacaa      960

gtaactctaa cagaagaaga gataaagtac ctcgaggagc cctacaaacc ccagaggcaa     1020

agatgttaa                                                             1029


<210>  61
<211>  344
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  61

Met Ser Ser Ser Val Ala Ser Thr Glu Asn Ile Val Glu Asn Met Leu 
1               5                   10                  15      


His Pro Lys Thr Thr Glu Ile Tyr Phe Ser Leu Asn Asn Gly Val Arg 
            20                  25                  30          


Ile Pro Ala Leu Gly Leu Gly Thr Ala Asn Pro His Glu Lys Leu Ala 
        35                  40                  45              


Glu Thr Lys Gln Ala Val Lys Ala Ala Ile Lys Ala Gly Tyr Arg His 
    50                  55                  60                  


Ile Asp Thr Ala Trp Ala Tyr Glu Thr Glu Pro Phe Val Gly Glu Ala 
65                  70                  75                  80  


Ile Lys Glu Leu Leu Glu Asp Gly Ser Ile Lys Arg Glu Asp Leu Phe 
                85                  90                  95      


Ile Thr Thr Lys Val Trp Pro Val Leu Trp Asp Glu Val Asp Arg Ser 
            100                 105                 110         


Leu Asn Glu Ser Leu Lys Ala Leu Gly Leu Glu Tyr Val Asp Leu Leu 
        115                 120                 125             


Leu Gln His Trp Pro Leu Cys Phe Glu Lys Ile Lys Asp Pro Lys Gly 
    130                 135                 140                 


Ile Ser Gly Leu Val Lys Thr Pro Val Asp Asp Ser Gly Lys Thr Met 
145                 150                 155                 160 


Tyr Ala Ala Asp Gly Asp Tyr Leu Glu Thr Tyr Lys Gln Leu Glu Lys 
                165                 170                 175     


Ile Tyr Leu Asp Pro Asn Asp His Arg Val Arg Ala Ile Gly Val Ser 
            180                 185                 190         


Asn Phe Ser Ile Glu Tyr Leu Glu Arg Leu Ile Lys Glu Cys Arg Val 
        195                 200                 205             


Lys Pro Thr Val Asn Gln Val Glu Thr His Pro His Leu Pro Gln Met 
    210                 215                 220                 


Glu Leu Arg Lys Phe Cys Phe Met His Asp Ile Leu Leu Thr Ala Tyr 
225                 230                 235                 240 


Ser Pro Leu Gly Ser His Gly Ala Pro Asn Leu Lys Ile Pro Leu Val 
                245                 250                 255     


Lys Lys Leu Ala Glu Lys Tyr Asn Val Thr Gly Asn Asp Leu Leu Ile 
            260                 265                 270         


Ser Tyr His Ile Arg Gln Gly Thr Ile Val Ile Pro Arg Ser Leu Asn 
        275                 280                 285             


Pro Val Arg Ile Ser Ser Ser Ile Glu Phe Ala Ser Leu Thr Lys Asp 
    290                 295                 300                 


Glu Leu Gln Glu Leu Asn Asp Phe Gly Glu Lys Tyr Pro Val Arg Phe 
305                 310                 315                 320 


Ile Asp Glu Pro Phe Ala Ala Ile Leu Pro Glu Phe Thr Gly Asn Gly 
                325                 330                 335     


Pro Asn Leu Asp Asn Leu Lys Tyr 
            340                 


<210>  62
<211>  1035
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  62
atgtcttctt cagtagcctc aaccgaaaac atagtcgaaa atatgttgca tccaaagact       60

acagaaatat acttttcact caacaatggt gttcgtatcc cagcactggg tttggggaca      120

gcaaatcctc acgaaaagtt agctgaaaca aaacaagccg taaaagctgc aatcaaagct      180

ggatacaggc acattgatac tgcttgggcc tacgagacag agccattcgt aggtgaagcc      240

atcaaggagt tattagaaga tggatctatc aaaagggagg atcttttcat aaccacaaaa      300

gtgtggccgg ttctatggga cgaagtggac agatcattga atgaatcttt gaaagcttta      360

ggcttggaat acgtcgactt gctcttgcaa cattggccgc tatgttttga aaagattaag      420

gaccctaagg ggatcagcgg actggtgaag actccggttg atgattctgg aaaaacaatg      480

tatgctgccg acggtgacta tttagaaact tacaagcaat tggaaaaaat ttaccttgat      540

cctaacgatc atcgtgtgag agccattggt gtctcaaatt tttccattga gtatttggaa      600

cgtctcatta aggaatgcag agttaagcca acggtgaacc aagtggaaac tcaccctcac      660

ttaccacaaa tggaactaag aaagttctgc tttatgcacg acattctgtt aacagcatac      720

tcaccattag gttcccatgg cgcaccaaac ttgaaaatcc cactagtgaa aaagcttgcc      780

gaaaagtaca atgtcacagg aaatgacttg ctaatttctt accatattag acaaggcact      840

atcgtaattc cgagatcctt gaatccagtt aggatttcct cgagtattga attcgcatct      900

ttgacaaagg atgaattaca agagttgaac gacttcggtg aaaaataccc agtgagattc      960

atcgatgagc catttgcagc catccttcca gagtttactg gtaacggacc aaacttggac     1020

aatttaaagt attaa                                                      1035


<210>  63
<211>  6311
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector pEVE2120

<400>  63
ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc       60

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct      120

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg      180

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc      240

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga      300

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct      360

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg      420

gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag      480

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat      540

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac      600

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac      660

tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc      720

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt      780

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc      840

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg      900

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca      960

atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca     1020

cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag     1080

ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac     1140

ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc     1200

agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct     1260

agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc     1320

gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg     1380

cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc     1440

gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat     1500

tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag     1560

tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat     1620

aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg     1680

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca     1740

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga     1800

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc     1860

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     1920

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg     1980

ccacctgggt ccttttcatc acgtgctata aaaataatta taatttaaat tttttaatat     2040

aaatatataa attaaaaata gaaagtaaaa aaagaaatta aagaaaaaat agtttttgtt     2100

ttccgaagat gtaaaagact ctagggggat cgccaacaaa tactaccttt tatcttgctc     2160

ttcctgctct caggtattaa tgccgaattg tttcatcttg tctgtgtaga agaccacaca     2220

cgaaaatcct gtgattttac attttactta tcgttaatcg aatgtatatc tatttaatct     2280

gcttttcttg tctaataaat atatatgtaa agtacgcttt ttgttgaaat tttttaaacc     2340

tttgtttatt tttttttctt cattccgtaa ctcttctacc ttctttattt actttctaaa     2400

atccaaatac aaaacataaa aataaataaa cacagagtaa attcccaaat tattccatca     2460

ttaaaagata cgaggcgcgt gtaagttaca ggcaagcgat ccgtcctaag aaaccattat     2520

tatcatgaca ttaacctata aaaataggcg tatcacgagg ccctttcgtc tcgcgcgttt     2580

cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca cagcttgtct     2640

gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg     2700

tcggggctgg cttaactatg cggcatcaga gcagattgta ctgagagtgc accataccac     2760

agcttttcaa ttcaattcat catttttttt ttattctttt ttttgatttc ggtttctttg     2820

aaattttttt gattcggtaa tctccgaaca gaaggaagaa cgaaggaagg agcacagact     2880

tagattggta tatatacgca tatgtagtgt tgaagaaaca tgaaattgcc cagtattctt     2940

aacccaactg cacagaacaa aaacctgcag gaaacgaaga taaatcatgt cgaaagctac     3000

atataaggaa cgtgctgcta ctcatcctag tcctgttgct gccaagctat ttaatatcat     3060

gcacgaaaag caaacaaact tgtgtgcttc attggatgtt cgtaccacca aggaattact     3120

ggagttagtt gaagcattag gtcccaaaat ttgtttacta aaaacacatg tggatatctt     3180

gactgatttt tccatggagg gcacagttaa gccgctaaag gcattatccg ccaagtacaa     3240

ttttttactc ttcgaagaca gaaaatttgc tgacattggt aatacagtca aattgcagta     3300

ctctgcgggt gtatacagaa tagcagaatg ggcagacatt acgaatgcac acggtgtggt     3360

gggcccaggt attgttagcg gtttgaagca ggcggcagaa gaagtaacaa aggaacctag     3420

aggccttttg atgttagcag aattgtcatg caagggctcc ctatctactg gagaatatac     3480

taagggtact gttgacattg cgaagagcga caaagatttt gttatcggct ttattgctca     3540

aagagacatg ggtggaagag atgaaggtta cgattggttg attatgacac ccggtgtggg     3600

tttagatgac aagggagacg cattgggtca acagtataga accgtggatg atgtggtctc     3660

tacaggatct gacattatta ttgttggaag aggactattt gcaaagggaa gggatgctaa     3720

ggtagagggt gaacgttaca gaaaagcagg ctgggaagca tatttgagaa gatgcggcca     3780

gcaaaactaa aaaactgtat tataagtaaa tgcatgtata ctaaactcac aaattagagc     3840

ttcaatttaa ttatatcagt tattacccta tgcggtgtga aataccgcac agatgcgtaa     3900

ggagaaaata ccgcatcagg aaattgtaaa cgttaatatt ttgttaaaat tcgcgttaaa     3960

tttttgttaa atcagctcat tttttaacca ataggccgaa atcggcaaaa tcccttataa     4020

atcaaaagaa tagaccgaga tagggttgag tgttgttcca gtttggaaca agagtccact     4080

attaaagaac gtggactcca acgtcaaagg gcgaaaaacc gtctatcagg gcgatggccc     4140

actacgtgaa ccatcaccct aatcaagttt tttggggtcg aggtgccgta aagcactaaa     4200

tcggaaccct aaagggagcc cccgatttag agcttgacgg ggaaagccgg cgaacgtggc     4260

gagaaaggaa gggaagaaag cgaaaggagc gggcgctagg gcgctggcaa gtgtagcggt     4320

cacgctgcgc gtaaccacca cacccgccgc gcttaatgcg ccgctacagg gcgcgtcgcg     4380

ccattcgcca ttcaggctgc gcaactgttg ggaagggcga tcggtgcggg cctcttcgct     4440

attacgccag ctgatttgcc cgggcagttc aggctcatca ggcgcgccat gcaggatgca     4500

ttgatcagtt aacccatggg catgcgaagg aaaatgagaa atatcgaggg agacgattca     4560

gaggagcagg acaaactata accgactgtt tgttggagga tgccgtacat aacgaacact     4620

gctgaagcta ccatgtctac agtttagagg aatgggtaca actcacaggc gagggatggt     4680

gttcactcgt gctagcaaac gcggtgggag caaaaagtag aatattatct tttattcgtg     4740

aaacttcgaa cactgtcatc taaagatgct atatactaat ataggcatac ttgataatga     4800

aaactataaa tcgtaaagac ataagagatc cgcggatccc cgggtcgagc ctgaacggcc     4860

tcgaggcctg aacggcctcg acgaattcat tatttgtaga gctcatccat gccatgtgta     4920

atcccagcag cagttacaaa ctcaagaagg accatgtggt cacgcttttc gttgggatct     4980

ttcgaaaggg cagattgtgt cgacaggtaa tggttgtctg gtaaaaggac agggccatcg     5040

ccaattggag tattttgttg ataatggtct gctagttgaa cggatccatc ttcaatgttg     5100

tggcgaattt tgaagttagc tttgattcca ttcttttgtt tgtctgccgt gatgtataca     5160

ttgtgtgagt tatagttgta ctcgagtttg tgtccgagaa tgtttccatc ttctttaaaa     5220

tcaatacctt ttaactcgat acgattaaca agggtatcac cttcaaactt gacttcagca     5280

cgcgtcttgt agttcccgtc atctttgaaa gatatagtgc gttcctgtac ataaccttcg     5340

ggcatggcac tcttgaaaaa gtcatgccgt ttcatatgat ccggataacg ggaaaagcat     5400

tgaacaccat aagagaaagt agtgacaagt gttggccatg gaacaggtag ttttccagta     5460

gtgcaaataa atttaagggt aagctggccc tgcaggccaa gctttgtttt atatttgttg     5520

taaaaagtag ataattactt ccttgatgat ctgtaaaaaa gagaaaaaga aagcatctaa     5580

gaacttgaaa aactacgaat tagaaaagac caaatatgta tttcttgcat tgaccaattt     5640

atgcaagttt atatatatgt aaatgtaagt ttcacgaggt tctactaaac taaaccaccc     5700

ccttggttag aagaaaagag tgtgtgagaa caggctgttg ttgtcacacg attcggacaa     5760

ttctgtttga aagagagaga gtaacagtac gatcgaacga actttgctct ggagatcaca     5820

gtgggcatca tagcatgtgg tactaaaccc tttcccgcca ttccagaacc ttcgattgct     5880

tgttacaaaa cctgtgagcc gtcgctagga ccttgttgtg tgacgaaatt ggaagctgca     5940

atcaatagga agacaggaag tcgagcgtgt ctgggttttt tcagttttgt tctttttgca     6000

aacaaatcac gagcgacggt aatttctttc tcgataagag gccacgtgct ttatgagggt     6060

aacatcaatt caagaaggag ggaaacactt cctttttctg gccctgataa tagtatgagg     6120

gtgaagccaa aataaaggat tcgcgcccaa atcggcatct ttaaatgcag gtatgcgata     6180

gttcctcact ctttccttac tcacgagtaa ttcttgcaaa tgcctattat gcagatgtta     6240

taatatctgt gcgtagatct gatatccctg catggcgcgc ctgatgagcc tgaactgccc     6300

gggcaaatca g                                                          6311


<210>  64
<211>  6248
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  vector pEVE27735

<400>  64
ctgatttgcc cgggcagttc aggctcatca ggcgcgccat gcagggatat cagatctacg       60

cacagatatt ataacatctg cataataggc atttgcaaga attactcgtg agtaaggaaa      120

gagtgaggaa ctatcgcata cctgcattta aagatgccga tttgggcgcg aatcctttat      180

tttggcttca ccctcatact attatcaggg ccagaaaaag gaagtgtttc cctccttctt      240

gaattgatgt taccctcata aagcacgtgg cctcttatcg agaaagaaat taccgtcgct      300

cgtgatttgt ttgcaaaaag aacaaaactg aaaaaaccca gacacgctcg acttcctgtc      360

ttcctattga ttgcagcttc caatttcgtc acacaacaag gtcctagcga cggctcacag      420

gttttgtaac aagcaatcga aggttctgga atggcgggaa agggtttagt accacatgct      480

atgatgccca ctgtgatctc cagagcaaag ttcgttcgat cgtactgtta ctctctctct      540

ttcaaacaga attgtccgaa tcgtgtgaca acaacagcct gttctcacac actcttttct      600

tctaaccaag ggggtggttt agtttagtag aacctcgtga aacttacatt tacatatata      660

taaacttgca taaattggtc aatgcaagaa atacatattt ggtcttttct aattcgtagt      720

ttttcaagtt cttagatgct ttctttttct cttttttaca gatcatcaag gaagtaatta      780

tctacttttt acaacaaata taaaacaaag cttaaaatga gaatggaagt cgtcttggtc      840

gttttcttga tgttcattgg tactatcaac tgcgaaagat tgatcttcaa tggtagacct      900

ttgttgcaca gagttaccaa agaagaaacc gttatgttgt accacgaatt ggaagttgct      960

gcttctgctg atgaagtttg gtctgttgaa ggttctccag aattgggttt acatttgcca     1020

gatttgttgc cagctggtat ttttgccaag ttcgaaatta ctggtgatgg tggtgaaggt     1080

tccattttgg atatgacttt tccaccaggt caattcccac atcattacag agaaaagttc     1140

gtctttttcg accacaagaa cagatacaag ttggtcgaac aaatcgatgg tgatttcttc     1200

gatttgggtg ttacttacta catggacacc attagagttg ttgctactgg tccagattct     1260

tgcgttatta agtctactac tgaataccac gtcaagccag aatttgctaa aatcgttaag     1320

ccattgatcg ataccgttcc attggctatt atgtctgaag ctattgccaa ggttgtcttg     1380

gaaaacaaac acaagtcatc tgaatgaaag actccgcgga tctcttatgt ctttacgatt     1440

tatagttttc attatcaagt atgcctatat tagtatatag catctttaga tgacagtgtt     1500

cgaagtttca cgaataaaag ataatattct actttttgct cccaccgcgt ttgctagcac     1560

gagtgaacac catccctcgc ctgtgagttg tacccattcc tctaaactgt agacatggta     1620

gcttcagcag tgttcgttat gtacggcatc ctccaacaaa cagtcggtta tagtttgtcc     1680

tgctcctctg aatcgtctcc ctcgatattt ctcattttcc ttcgcatgcc catgggttaa     1740

ctgatcaatg catcctgcat ggcgcgcctg atgagcctga actgcccggg caaatcagct     1800

ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg     1860

gcgaatggcg cgacgcgccc tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc     1920

gcagcgtgac cgctacactt gccagcgccc tagcgcccgc tcctttcgct ttcttccctt     1980

cctttctcgc cacgttcgcc ggctttcccc gtcaagctct aaatcggggg ctccctttag     2040

ggttccgatt tagtgcttta cggcacctcg accccaaaaa acttgattag ggtgatggtt     2100

cacgtagtgg gccatcgccc tgatagacgg tttttcgccc tttgacgttg gagtccacgt     2160

tctttaatag tggactcttg ttccaaactg gaacaacact caaccctatc tcggtctatt     2220

cttttgattt ataagggatt ttgccgattt cggcctattg gttaaaaaat gagctgattt     2280

aacaaaaatt taacgcgaat tttaacaaaa tattaacgtt tacaatttcc tgatgcggta     2340

ttttctcctt acgcatctgt gcggtatttc acaccgcata gggtaataac tgatataatt     2400

aaattgaagc tctaatttgt gagtttagta tacatgcatt tacttataat acagtttttt     2460

agttttgctg gccgcatctt ctcaaatatg cttcccagcc tgcttttctg taacgttcac     2520

cctctacctt agcatccctt ccctttgcaa atagtcctct tccaacaata ataatgtcag     2580

atcctgtaga gaccacatca tccacggttc tatactgttg acccaatgcg tctcccttgt     2640

catctaaacc cacaccgggt gtcataatca accaatcgta accttcatct cttccaccca     2700

tgtctctttg agcaataaag ccgataacaa aatctttgtc gctcttcgca atgtcaacag     2760

tacccttagt atattctcca gtagataggg agcccttgca tgacaattct gctaacatca     2820

aaaggcctct aggttccttt gttacttctt ctgccgcctg cttcaaaccg ctaacaatac     2880

ctgggcccac cacaccgtgt gcattcgtaa tgtctgccca ttctgctatt ctgtatacac     2940

ccgcagagta ctgcaatttg actgtattac caatgtcagc aaattttctg tcttcgaaga     3000

gtaaaaaatt gtacttggcg gataatgcct ttagcggctt aactgtgccc tccatggaaa     3060

aatcagtcaa gatatccaca tgtgttttta gtaaacaaat tttgggacct aatgcttcaa     3120

ctaactccag taattccttg gtggtacgaa catccaatga agcacacaag tttgtttgct     3180

tttcgtgcat gatattaaat agcttggcag caacaggact aggatgagta gcagcacgtt     3240

ccttatatgt agctttcgac atgatttatc ttcgtttcct gcaggttttt gttctgtgca     3300

gttgggttaa gaatactggg caatttcatg tttcttcaac actacatatg cgtatatata     3360

ccaatctaag tctgtgctcc ttccttcgtt cttccttctg ttcggagatt accgaatcaa     3420

aaaaatttca aagaaaccga aatcaaaaaa aagaataaaa aaaaaatgat gaattgaatt     3480

gaaaagctgt ggtatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc     3540

agccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat     3600

ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt     3660

catcaccgaa acgcgcgaga cgaaagggcc tcgtgatacg cctattttta taggttaatg     3720

tcatgataat aatggtttct taggacggat cgcttgcctg taacttacac gcgcctcgta     3780

tcttttaatg atggaataat ttgggaattt actctgtgtt tatttatttt tatgttttgt     3840

atttggattt tagaaagtaa ataaagaagg tagaagagtt acggaatgaa gaaaaaaaaa     3900

taaacaaagg tttaaaaaat ttcaacaaaa agcgtacttt acatatatat ttattagaca     3960

agaaaagcag attaaataga tatacattcg attaacgata agtaaaatgt aaaatcacag     4020

gattttcgtg tgtggtcttc tacacagaca agatgaaaca attcggcatt aatacctgag     4080

agcaggaaga gcaagataaa aggtagtatt tgttggcgat ccccctagag tcttttacat     4140

cttcggaaaa caaaaactat tttttcttta atttcttttt ttactttcta tttttaattt     4200

atatatttat attaaaaaat ttaaattata attattttta tagcacgtga tgaaaaggac     4260

ccaggtggca cttttcgggg aaatgtgcgc ggaaccccta tttgtttatt tttctaaata     4320

cattcaaata tgtatccgct catgagacaa taaccctgat aaatgcttca ataatattga     4380

aaaaggaaga gtatgagtat tcaacatttc cgtgtcgccc ttattccctt ttttgcggca     4440

ttttgccttc ctgtttttgc tcacccagaa acgctggtga aagtaaaaga tgctgaagat     4500

cagttgggtg cacgagtggg ttacatcgaa ctggatctca acagcggtaa gatccttgag     4560

agttttcgcc ccgaagaacg ttttccaatg atgagcactt ttaaagttct gctatgtggc     4620

gcggtattat cccgtattga cgccgggcaa gagcaactcg gtcgccgcat acactattct     4680

cagaatgact tggttgagta ctcaccagtc acagaaaagc atcttacgga tggcatgaca     4740

gtaagagaat tatgcagtgc tgccataacc atgagtgata acactgcggc caacttactt     4800

ctgacaacga tcggaggacc gaaggagcta accgcttttt tgcacaacat gggggatcat     4860

gtaactcgcc ttgatcgttg ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt     4920

gacaccacga tgcctgtagc aatggcaaca acgttgcgca aactattaac tggcgaacta     4980

cttactctag cttcccggca acaattaata gactggatgg aggcggataa agttgcagga     5040

ccacttctgc gctcggccct tccggctggc tggtttattg ctgataaatc tggagccggt     5100

gagcgtgggt ctcgcggtat cattgcagca ctggggccag atggtaagcc ctcccgtatc     5160

gtagttatct acacgacggg gagtcaggca actatggatg aacgaaatag acagatcgct     5220

gagataggtg cctcactgat taagcattgg taactgtcag accaagttta ctcatatata     5280

ctttagattg atttaaaact tcatttttaa tttaaaagga tctaggtgaa gatccttttt     5340

gataatctca tgaccaaaat cccttaacgt gagttttcgt tccactgagc gtcagacccc     5400

gtagaaaaga tcaaaggatc ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg     5460

caaacaaaaa aaccaccgct accagcggtg gtttgtttgc cggatcaaga gctaccaact     5520

ctttttccga aggtaactgg cttcagcaga gcgcagatac caaatactgt ccttctagtg     5580

tagccgtagt taggccacca cttcaagaac tctgtagcac cgcctacata cctcgctctg     5640

ctaatcctgt taccagtggc tgctgccagt ggcgataagt cgtgtcttac cgggttggac     5700

tcaagacgat agttaccgga taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca     5760

cagcccagct tggagcgaac gacctacacc gaactgagat acctacagcg tgagctatga     5820

gaaagcgcca cgcttcccga agggagaaag gcggacaggt atccggtaag cggcagggtc     5880

ggaacaggag agcgcacgag ggagcttcca gggggaaacg cctggtatct ttatagtcct     5940

gtcgggtttc gccacctctg acttgagcgt cgatttttgt gatgctcgtc aggggggcgg     6000

agcctatgga aaaacgccag caacgcggcc tttttacggt tcctggcctt ttgctggcct     6060

tttgctcaca tgttctttcc tgcgttatcc cctgattctg tggataaccg tattaccgcc     6120

tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc     6180

gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat     6240

taatgcag                                                              6248


