                         SEQUENCE LISTING

<110>  Universit de Namur ASBL
 
<120>  LIPOPROTEIN EXPORT SIGNALS AND USES THEREOF

<130>  UNA-005-PCT

<150>  EP 16183962.6
<151>  2016-08-12

<160>  206   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Bacteroides fragilis

<400>  1

Ser Asp Asp Asp Asp 
1               5   


<210>  2
<211>  5
<212>  PRT
<213>  Flavobacterium johnsoniae

<400>  2

Ser Asp Asp Phe Glu 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  3

Ser Glu Glu Glu Glu 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  4

Ser Asp Glu Asp Glu 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  5

Ser Glu Asp Glu Asp 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  6

Ser Asp Asp Glu Glu 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  7

Ser Glu Glu Asp Asp 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  8

Ser Glu Glu Glu Asp 
1               5   


<210>  9
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  9

Ser Asp Asp Asp Glu 
1               5   


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 2

<400>  10

Ser Glu Glu Phe Glu 
1               5   


<210>  11
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 2

<400>  11

Ser Glu Glu Phe Asp 
1               5   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 2

<400>  12

Ser Glu Asp Phe Glu 
1               5   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 2

<400>  13

Ser Asp Glu Phe Glu 
1               5   


<210>  14
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 2

<400>  14

Ser Glu Asp Phe Asp 
1               5   


<210>  15
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 2

<400>  15

Ser Asp Glu Phe Asp 
1               5   


<210>  16
<211>  5
<212>  PRT
<213>  Capnocytophaga canimorsus

<400>  16

Gln Lys Asp Asp Glu 
1               5   


<210>  17
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 16

<400>  17

Ala Lys Asp Asp Glu 
1               5   


<210>  18
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 16

<400>  18

Ala Lys Asp Asp Ala 
1               5   


<210>  19
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 16

<400>  19

Ala Lys Glu Glu Ala 
1               5   


<210>  20
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 16

<400>  20

Gln Ala Asp Asp Glu 
1               5   


<210>  21
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  any amino acid

<400>  21

Cys Xaa Lys Asp Glu Xaa 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  any amino acid

<400>  22

Cys Xaa Lys Glu Asp Xaa 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  any amino acid

<400>  23

Cys Xaa Lys Asp Asp Xaa 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  any amino acid

<400>  24

Cys Xaa Lys Glu Glu Xaa 
1               5       


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  25

Thr Asp Asp Asp Asp 
1               5   


<210>  26
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 2

<400>  26

Thr Asp Asp Phe Glu 
1               5   


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  27

Thr Glu Glu Glu Glu 
1               5   


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  28

Thr Asp Glu Asp Glu 
1               5   


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  29

Thr Glu Asp Glu Asp 
1               5   


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  30

Thr Asp Asp Glu Glu 
1               5   


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  31

Thr Glu Glu Asp Asp 
1               5   


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  32

Thr Glu Glu Glu Asp 
1               5   


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 1

<400>  33

Thr Asp Asp Asp Glu 
1               5   


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 2

<400>  34

Thr Glu Glu Phe Glu 
1               5   


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 2

<400>  35

Thr Glu Glu Phe Asp 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 2

<400>  36

Thr Glu Asp Phe Glu 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 2

<400>  37

Thr Asp Glu Phe Glu 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 2

<400>  38

Thr Glu Asp Phe Asp 
1               5   


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 2

<400>  39

Thr Asp Glu Phe Asp 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  any amino acid

<400>  40

Xaa Lys Asp Asp Asp 
1               5   


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  any amino acid

<400>  41

Xaa Lys Glu Glu Glu 
1               5   


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  any amino acid

<400>  42

Xaa Lys Asp Asp Glu 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  any amino acid

<400>  43

Xaa Lys Asp Glu Asp 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  any amino acid

<400>  44

Xaa Lys Asp Glu Glu 
1               5   


<210>  45
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  any amino acid

<400>  45

Xaa Lys Glu Asp Glu 
1               5   


<210>  46
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  any amino acid

<400>  46

Xaa Lys Glu Asp Asp 
1               5   


<210>  47
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  any amino acid

<400>  47

Xaa Lys Glu Glu Asp 
1               5   


<210>  48
<211>  10
<212>  PRT
<213>  Capnocytophaga canimorsus

<400>  48

Cys Lys Lys Glu Val Glu Val Glu Glu Glu 
1               5                   10  


<210>  49
<211>  7
<212>  PRT
<213>  Capnocytophaga canimorsus

<400>  49

Lys Lys Glu Val Glu Glu Glu 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 49

<400>  50

Ala Lys Glu Val Glu Glu Glu 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 49

<400>  51

Lys Lys Glu Ala Glu Glu Glu 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 49

<400>  52

Lys Lys Glu Val Glu Ala Glu 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 49

<400>  53

Lys Ala Glu Val Glu Glu Glu 
1               5           


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 49

<400>  54

Lys Lys Ala Val Glu Glu Glu 
1               5           


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 49

<400>  55

Lys Lys Glu Val Ala Glu Glu 
1               5           


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 49

<400>  56

Ala Ala Glu Val Glu Glu Glu 
1               5           


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 49

<400>  57

Lys Lys Ala Ala Ala Ala Ala 
1               5           


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 49

<400>  58

Lys Lys Ala Ala Ala Glu Glu 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 49

<400>  59

Lys Lys Glu Val Ala Ala Ala 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 49

<400>  60

Arg Arg Glu Val Glu Glu Glu 
1               5           


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 49

<400>  61

Arg Ala Glu Val Glu Glu Glu 
1               5           


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 49

<400>  62

Ala Arg Glu Val Glu Glu Glu 
1               5           


<210>  63
<211>  6
<212>  PRT
<213>  Capnocytophaga canimorsus

<400>  63

Lys Lys Glu Val Glu Glu 
1               5       


<210>  64
<211>  5
<212>  PRT
<213>  Capnocytophaga canimorsus

<400>  64

Lys Lys Glu Val Glu 
1               5   


<210>  65
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 64

<400>  65

Lys Ala Glu Val Glu 
1               5   


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 64

<400>  66

Ala Lys Glu Val Glu 
1               5   


<210>  67
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated sequence of SEQ ID 64

<400>  67

Lys Glu Val Glu Glu 
1               5   


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is selected from K, S, T and A with the proviso that when X(2) 
       is A, X(1) is Q

<400>  68

Xaa Xaa Asp Asp 
1               


<210>  69
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is selected from K, S, T and A, with the proviso that when X(2)
       is A, X(1) is Q

<400>  69

Xaa Xaa Asp Glu 
1               


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is selected from K, S, T and A, with the proviso that when X(2)
       is A, X(1) is Q

<400>  70

Xaa Xaa Glu Asp 
1               


<210>  71
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is selected from K, S, T and A, with the proviso that when X(2)
       is A, X(1) is Q

<400>  71

Xaa Xaa Glu Glu 
1               


<210>  72
<211>  30
<212>  DNA
<213>  Primer

<400>  72
cataccatgg gaaatcgaat tttttatctt                                        30


<210>  73
<211>  76
<212>  DNA
<213>  Primer

<400>  73
catgccatgg gaaatcgaat tttttatctt ttattcgctt ttgttctttt gtcggctggt       60

ggaagccaaa aaaacg                                                       76


<210>  74
<211>  31
<212>  DNA
<213>  Primer

<400>  74
ggccatgggg aaaaaaatag tatccattag c                                      31


<210>  75
<211>  80
<212>  DNA
<213>  Primer

<400>  75
ggccatgggg aaaaaaatag tatccattag cttatttttc cttatctcag caactatttg       60

gttagccggt aaaaaggaag                                                   80


<210>  76
<211>  35
<212>  DNA
<213>  Primer

<400>  76
tggttagcct gtgcaaagga agttgaagaa gaacc                                  35


<210>  77
<211>  35
<212>  DNA
<213>  Primer

<400>  77
ggttcttctt caacttcctt tgcacaggct aacca                                  35


<210>  78
<211>  37
<212>  DNA
<213>  Primer

<400>  78
ttagcctgta aagcggaagt tgaagaagaa ccttttc                                37


<210>  79
<211>  37
<212>  DNA
<213>  Primer

<400>  79
gaaaaggttc ttcttcaact tccgctttac aggctaa                                37


<210>  80
<211>  38
<212>  DNA
<213>  Primer

<400>  80
gcctgtaaaa aggcagttga agaagaacct tttctaac                               38


<210>  81
<211>  38
<212>  DNA
<213>  Primer

<400>  81
gttagaaaag gttcttcttc aactgccttt ttacaggc                               38


<210>  82
<211>  35
<212>  DNA
<213>  Primer

<400>  82
tgtaaaaagg aagctgaaga agaacctttt ctaac                                  35


<210>  83
<211>  35
<212>  DNA
<213>  Primer

<400>  83
gttagaaaag gttcttcttc agcttccttt ttaca                                  35


<210>  84
<211>  37
<212>  DNA
<213>  Primer

<400>  84
aaaaaggaag ttgcagaaga accttttcta acaatag                                37


<210>  85
<211>  37
<212>  DNA
<213>  Primer

<400>  85
ctattgttag aaaaggttct tctgcaactt ccttttt                                37


<210>  86
<211>  35
<212>  DNA
<213>  Primer

<400>  86
tggttagcct gtgcagcgga agttgaagaa gaacc                                  35


<210>  87
<211>  35
<212>  DNA
<213>  Primer

<400>  87
ggttcttctt caacttccgc tgcacaggct aacca                                  35


<210>  88
<211>  38
<212>  DNA
<213>  Primer

<400>  88
gcctgtaaaa aggcagctgc agaagaacct tttctaac                               38


<210>  89
<211>  38
<212>  DNA
<213>  Primer

<400>  89
gttagaaaag gttcttctgc agctgccttt ttacaggc                               38


<210>  90
<211>  37
<212>  DNA
<213>  Primer

<400>  90
aaaaaggaag ttgcagcagc accttttcta acaatag                                37


<210>  91
<211>  37
<212>  DNA
<213>  Primer

<400>  91
ctattgttag aaaaggtgct gctgcaactt ccttttt                                37


<210>  92
<211>  39
<212>  DNA
<213>  Primer

<400>  92
gttgaagaag aagcttttct aacaatagaa gaaaaaacc                              39


<210>  93
<211>  39
<212>  DNA
<213>  Primer

<400>  93
ggttttttct tctattgtta gaaaagcttc ttcttcaac                              39


<210>  94
<211>  57
<212>  DNA
<213>  Primer

<400>  94
ggctcgagct aagcgtaatc tggaacatcg tatgggtaaa acgtaacttg agttctc          57


<210>  95
<211>  35
<212>  DNA
<213>  Primer

<400>  95
ggctcgagtt agttcttgat aaattcctca actgg                                  35


<210>  96
<211>  40
<212>  DNA
<213>  Primer

<400>  96
tggttagcct gtagagcgga agttgaagaa gaaccttttc                             40


<210>  97
<211>  40
<212>  DNA
<213>  Primer

<400>  97
gaaaaggttc ttcttcaact tccgctctac aggctaacca                             40


<210>  98
<211>  37
<212>  DNA
<213>  Primer

<400>  98
ttagcctgtg caagagaagt tgaagaagaa ccttttc                                37


<210>  99
<211>  37
<212>  DNA
<213>  Primer

<400>  99
gaaaaggttc ttcttcaact tctcttgcac aggctaa                                37


<210>  100
<211>  40
<212>  DNA
<213>  Primer

<400>  100
tggttagcct gtagaagaga agttgaagaa gaaccttttc                             40


<210>  101
<211>  40
<212>  DNA
<213>  Primer

<400>  101
gaaaaggttc ttcttcaact tctcttctac aggctaacca                             40


<210>  102
<211>  42
<212>  DNA
<213>  Primer

<400>  102
gcagctgcag cggctccttt tctaacaata gaagaaaaaa cc                          42


<210>  103
<211>  42
<212>  DNA
<213>  Primer

<400>  103
agccgctgca gctgcctttt tacaggctaa ccaaatagtt gc                          42


<210>  104
<211>  52
<212>  DNA
<213>  Primer

<400>  104
aaaaaggaag ttgaagaaga agtaatcggc ggaggcgaat ttacacaacc cg               52


<210>  105
<211>  46
<212>  DNA
<213>  Primer

<400>  105
ttcttcttca acttcctttt tacaagccga caaaagaaca aaagcg                      46


<210>  106
<211>  46
<212>  DNA
<213>  Primer

<400>  106
aaaaaggaag ttgaagtaat cggcggaggc gaatttacac aacccg                      46


<210>  107
<211>  40
<212>  DNA
<213>  Primer

<400>  107
ttcaacttcc tttttacaag ccgacaaaag aacaaaagcg                             40


<210>  108
<211>  46
<212>  DNA
<213>  Primer

<400>  108
gcaaaggaag ttgaagtaat cggcggaggc gaatttacac aacccg                      46


<210>  109
<211>  40
<212>  DNA
<213>  Primer

<400>  109
ttcaacttcc tttgcacaag ccgacaaaag aacaaaagcg                             40


<210>  110
<211>  46
<212>  DNA
<213>  Primer

<400>  110
aaagcggaag ttgaagtaat cggcggaggc gaatttacac aacccg                      46


<210>  111
<211>  40
<212>  DNA
<213>  Primer

<400>  111
ttcaacttcc gctttacaag ccgacaaaag aacaaaagcg                             40


<210>  112
<211>  44
<212>  DNA
<213>  Primer

<400>  112
aggaagttga agcagaacct tttctaacaa tagaagaaaa aacc                        44


<210>  113
<211>  39
<212>  DNA
<213>  Primer

<400>  113
gaaaaggttc tgcttcaact tcctttttac aggctaacc                              39


<210>  114
<211>  43
<212>  DNA
<213>  Primer

<400>  114
ggaagttgaa gaagcacctt ttctaacaat agaagaaaaa acc                         43


<210>  115
<211>  48
<212>  DNA
<213>  Primer

<400>  115
gaaaaggtgc ttcttcaact tcctttttac aggctaacca aatagttg                    48


<210>  116
<211>  46
<212>  DNA
<213>  Primer

<400>  116
aaggaagttg aagaagtaat cggcggaggc gaatttacac aacccg                      46


<210>  117
<211>  40
<212>  DNA
<213>  Primer

<400>  117
ttcttcaact tccttacaag ccgacaaaag aacaaaagcg                             40


<210>  118
<211>  49
<212>  DNA
<213>  Primer

<400>  118
aaaaaggaag ttgaagaagt aatcggcgga ggcgaattta cacaacccg                   49


<210>  119
<211>  43
<212>  DNA
<213>  Primer

<400>  119
ttcttcaact tcctttttac aagccgacaa aagaacaaaa gcg                         43


<210>  120
<211>  46
<212>  DNA
<213>  Primer

<400>  120
caaaaggacg atgaagtaat cggcggaggc gaatttacac aacccg                      46


<210>  121
<211>  40
<212>  DNA
<213>  Primer

<400>  121
ttcatcgtcc ttttgacaag ccgacaaaag aacaaaagcg                             40


<210>  122
<211>  46
<212>  DNA
<213>  Primer

<400>  122
gcaaaggacg atgcagtaat cggcggaggc gaatttacac aacccg                      46


<210>  123
<211>  40
<212>  DNA
<213>  Primer

<400>  123
tgcatcgtcc tttgcacaag ccgacaaaag aacaaaagcg                             40


<210>  124
<211>  46
<212>  DNA
<213>  Primer

<400>  124
gcaaaggacg atgaagtaat cggcggaggc gaatttacac aacccg                      46


<210>  125
<211>  40
<212>  DNA
<213>  Primer

<400>  125
ttcatcgtcc tttgcacaag ccgacaaaag aacaaaagcg                             40


<210>  126
<211>  46
<212>  DNA
<213>  Primer

<400>  126
gcaaaggacg ctgcagtaat cggcggaggc gaatttacac aacccg                      46


<210>  127
<211>  40
<212>  DNA
<213>  Primer

<400>  127
tgcagcgtcc tttgcacaag ccgacaaaag aacaaaagcg                             40


<210>  128
<211>  46
<212>  DNA
<213>  Primer

<400>  128
gcaaaggaag ctgcagtaat cggcggaggc gaatttacac aacccg                      46


<210>  129
<211>  40
<212>  DNA
<213>  Primer

<400>  129
tgcagcttcc tttgcacaag ccgacaaaag aacaaaagcg                             40


<210>  130
<211>  46
<212>  DNA
<213>  Primer

<400>  130
gcaaaggaag aggcagtaat cggcggaggc gaatttacac aacccg                      46


<210>  131
<211>  40
<212>  DNA
<213>  Primer

<400>  131
tgcctcttcc tttgcacaag ccgacaaaag aacaaaagcg                             40


<210>  132
<211>  46
<212>  DNA
<213>  Primer

<400>  132
gctgcaaagg acgatgtaat cggcggaggc gaatttacac aacccg                      46


<210>  133
<211>  40
<212>  DNA
<213>  Primer

<400>  133
atcgtccttt gcagcacaag ccgacaaaag aacaaaagcg                             40


<210>  134
<211>  49
<212>  DNA
<213>  Primer

<400>  134
gcagctgcaa aggacgatgt aatcggcgga ggcgaattta cacaacccg                   49


<210>  135
<211>  43
<212>  DNA
<213>  Primer

<400>  135
atcgtccttt gcagctgcac aagccgacaa aagaacaaaa gcg                         43


<210>  136
<211>  52
<212>  DNA
<213>  Primer

<400>  136
gccgcagctg caaaggacga tgtaatcggc ggaggcgaat ttacacaacc cg               52


<210>  137
<211>  46
<212>  DNA
<213>  Primer

<400>  137
atcgtccttt gcagctgcgg cacaagccga caaaagaaca aaagcg                      46


<210>  138
<211>  46
<212>  DNA
<213>  Primer

<400>  138
tctgatgact tcgaagtaat cggcggaggc gaatttacac aacccg                      46


<210>  139
<211>  40
<212>  DNA
<213>  Primer

<400>  139
ttcgaagtca tcagaacaag ccgacaaaag aacaaaagcg                             40


<210>  140
<211>  46
<212>  DNA
<213>  Primer

<400>  140
caagcggacg atgaagtaat cggcggaggc gaatttacac aacccg                      46


<210>  141
<211>  40
<212>  DNA
<213>  Primer

<400>  141
ttcatcgtcc gcttgacaag ccgacaaaag aacaaaagcg                             40


<210>  142
<211>  46
<212>  DNA
<213>  Primer

<400>  142
gcagctgacg atgcagtaat cggcggaggc gaatttacac aacccg                      46


<210>  143
<211>  40
<212>  DNA
<213>  Primer

<400>  143
tgcatcgtca gctgcacaag ccgacaaaag aacaaaagcg                             40


<210>  144
<211>  46
<212>  DNA
<213>  Primer

<400>  144
aaggacgatg cagctgtaat cggcggaggc gaatttacac aacccg                      46


<210>  145
<211>  40
<212>  DNA
<213>  Primer

<400>  145
agctgcatcg tccttacaag ccgacaaaag aacaaaagcg                             40


<210>  146
<211>  46
<212>  DNA
<213>  Primer

<400>  146
agtgatgacg acgatgtaat cggcggaggc gaatttacac aacccg                      46


<210>  147
<211>  40
<212>  DNA
<213>  Primer

<400>  147
atcgtcgtca tcactacaag ccgacaaaag aacaaaagcg                             40


<210>  148
<211>  15
<212>  PRT
<213>  C. canimorsus - SiaC

<400>  148

Cys Gly Ser Gln Lys Asn Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  149
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  149

Gly Gly Ser Gln Lys Asn Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  150
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  150

Cys Gln Lys Asp Asp Glu Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  151
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  151

Cys Ala Lys Asp Asp Glu Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  152
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  152

Cys Ala Lys Asp Asp Ala Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  153
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  153

Cys Ala Lys Glu Glu Ala Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  154
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  154

Cys Ala Lys Asp Ala Ala Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  155
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  155

Cys Ala Lys Glu Ala Ala Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  156
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  156

Cys Gln Ala Asp Asp Glu Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  157
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  157

Cys Ala Ala Asp Asp Ala Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  158
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  158

Cys Gly Ser Gln Lys Asn Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  159
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  159

Cys Ala Lys Asp Asp Ala Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  160
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  160

Cys Ala Ala Lys Asp Asp Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  161
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  161

Cys Ala Ala Lys Asp Asp Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  162
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  162

Cys Ala Ala Ala Ala Lys Asp Asp Val Ile Gly Gly Gly Glu Phe Thr 
1               5                   10                  15      


Ile 
    


<210>  163
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  163

Cys Lys Asp Asp Ala Ala Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  164
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  164

Gly Gly Ser Gln Lys Asn Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  165
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  165

Cys Gln Lys Asp Asp Glu Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  166
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  166

Cys Lys Lys Glu Val Glu Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  167
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  167

Cys Lys Lys Glu Val Glu Glu Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15      


<210>  168
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  168

Cys Lys Lys Glu Val Glu Glu Glu Val Ile Gly Gly Gly Glu Phe Thr 
1               5                   10                  15      


Ile 
    


<210>  169
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  169

Cys Ser Asp Asp Phe Glu Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  170
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  170

Cys Ser Asp Asp Asp Asp Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  171
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  171

Cys Ala Lys Glu Val Glu Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  172
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  172

Cys Lys Ala Glu Val Glu Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  173
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 148

<400>  173

Cys Lys Glu Val Glu Glu Val Ile Gly Gly Gly Glu Phe Thr Ile 
1               5                   10                  15  


<210>  174
<211>  18
<212>  PRT
<213>  C. canimorsus MucG

<400>  174

Cys Lys Lys Glu Val Glu Glu Glu Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  175
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  175

Gly Lys Lys Glu Val Glu Glu Glu Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  176
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  176

Cys Ala Lys Glu Val Glu Glu Glu Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  177
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  177

Cys Lys Ala Glu Val Glu Glu Glu Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  178
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  178

Cys Lys Lys Ala Val Glu Glu Glu Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  179
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  179

Cys Lys Lys Glu Ala Glu Glu Glu Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  180
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  180

Cys Lys Lys Glu Val Ala Glu Glu Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  181
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  181

Cys Lys Lys Glu Val Glu Ala Glu Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  182
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  182

Cys Lys Lys Glu Val Glu Glu Ala Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  183
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  183

Cys Lys Lys Glu Val Glu Glu Glu Ala Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  184
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  184

Cys Ala Ala Glu Val Glu Glu Glu Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  185
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  185

Cys Lys Lys Ala Ala Ala Ala Ala Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  186
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  186

Cys Lys Lys Ala Ala Ala Glu Glu Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  187
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  187

Cys Lys Lys Glu Val Ala Ala Ala Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  188
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  188

Cys Arg Arg Glu Val Glu Glu Glu Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  189
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  189

Cys Arg Ala Glu Val Glu Glu Glu Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  190
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated sequence of SEQ ID NO 174

<400>  190

Cys Ala Arg Glu Val Glu Glu Glu Pro Phe Leu Thr Ile Glu Glu Lys 
1               5                   10                  15      


Thr Ile 
        


<210>  191
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can be any amino acid

<400>  191

Xaa Lys Asp Glu Xaa 
1               5   


<210>  192
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can be any amino acid

<400>  192

Xaa Lys Glu Asp Xaa 
1               5   


<210>  193
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can be any amino acid

<400>  193

Xaa Lys Asp Asp Xaa 
1               5   


<210>  194
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X can be any amino acid

<400>  194

Xaa Lys Glu Glu Xaa 
1               5   


<210>  195
<211>  19
<212>  PRT
<213>  C. canimorsus 5

<400>  195

Met Asn Arg Ile Phe Tyr Leu Leu Phe Ala Phe Val Leu Leu Ser Ala 
1               5                   10                  15      


Cys Gly Ser 
            


<210>  196
<211>  22
<212>  PRT
<213>  C. canimorsus 5

<400>  196

Met Lys Lys Ile Val Ser Ile Ser Leu Phe Phe Leu Ile Ser Ala Thr 
1               5                   10                  15      


Ile Trp Leu Ala Cys Lys 
            20          


<210>  197
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is selected from K and A, with the proviso  that when X(2) is 
       A, X(1) is Q

<220>
<221>  MISC_FEATURE
<222>  (3)..(4)
<223>  X is selected from D and E

<400>  197

Xaa Xaa Xaa Xaa 
1               


<210>  198
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X is selected from S and T

<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  X is selected from D and E

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X is selected from D, E and F

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is selected from D and E

<400>  198

Xaa Xaa Xaa Xaa Xaa 
1               5   


<210>  199
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X can be any amino acid

<400>  199

Xaa Lys Glu Xaa Glu 
1               5   


<210>  200
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X can be any amino acid

<400>  200

Xaa Lys Glu Xaa Glu Glu 
1               5       


<210>  201
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any amino acid

<400>  201

Xaa Lys Glu Val Glu 
1               5   


<210>  202
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LES consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X can be any amino acid

<400>  202

Xaa Lys Glu Val Glu Glu 
1               5       


<210>  203
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  lipobox motif


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is selected from S and A

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is selected from A and G

<400>  203

Leu Xaa Xaa Cys 
1               


<210>  204
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  204

Glu Asn Leu Tyr Phe Gln Gly 
1               5           


<210>  205
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  205

Asp Asp Asp Asp Lys 
1               5   


<210>  206
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protease cleavage site

<400>  206

Leu Val Pro Arg Gly Ser 
1               5       


