                         SEQUENCE LISTING

<110>  ARSANIS Biosciences GmbH
       Max-Planck-Gesellschaft zur Frderung der Wissenschaften 
       e.V.
 
<120>  KLEBSIELLA PNEUMONIAE O3 SPECIFIC ANTIBODIES

<130>  AR018P

<160>  79    

<170>  PatentIn version 3.5

<210>  1
<211>  367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH

<400>  1
gaagtgcagc tggtggagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc       60

tcctgtgaag cctctggctt cacctttagt aggaattgga tgagttgggt ccgccagatt      120

ccagggaagg ggctggagtg ggtggccgac ataaaggcag atggaagtga gaaagtctat      180

ctggactcta tgaagggccg attaaccatt tccagagaca acgccaggaa tttattgtat      240

ctgcaaatgg acagcctgag agtcgaggac tcggccctat atcactgtgc gagaggcccc      300

tcttatggtg acaggtgtga ctacttggac cactggggcc ggggagccct ggtcaccgtc      360

tcctcag                                                                367


<210>  2
<211>  367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH

<400>  2
gaggtgcagc tgttggagtc tgggggaggc ttggtgcagc cgggggggtc cctgagactc       60

tcctgtgcaa cctccggatt cacctttaac aactatgcca tccactgggt ccgccaggct      120

ccagggaagg ggctggaatg ggtctcagcc attggtggtg atggtcattc gacatattat      180

gtagaggccg tgaagggccg gttcaccatc tccagtgaca gttccaagaa cacggtatat      240

ctgcaggtga acagcctgag acccgaggac acggccctat attattgtgc gagagagggc      300

tatagtagtg gccggtgcgg gtcttttgac cactggggcc agggaaccct ggtcaccgtc      360

tcctcag                                                                367


<210>  3
<211>  361
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH

<400>  3
cagctgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgctctg tctctggtgt ctccatcagc aattttaatt actactgggg ctgggtccgc      120

cagcccccag ggaagccgct ggagtggatt gggactatct attataatgg aaacacctac      180

tacaacccgt ccctcaagag tcgagtcacc atatccgtag acacgtccaa gactcagttg      240

tccctgaagc tgctctctgt gaccgccgca gacacggctg tgtattactg tgcgtgggac      300

tccggttctg tggaaagatt tgaccactgg agccagggaa ccctggtcac cgtctcctca      360

g                                                                      361


<210>  4
<211>  367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH

<400>  4
gaagtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgttcaa cgtctggatt cgactttagt aggcattgga tgacctgggt ccgacaggct      120

ccagggaagg ggctggagtg ggtggccgac ataaagaaag atggaagtga ggagaactat      180

gtggacactg tgaagggccg actcaccatc tccagagaca acgccaggag gtcactctat      240

ctgcaaatga acagcctgag aaccgacgac acggccgtgt attattgtgc gagaggaccc      300

tcgtatggtg accggagtga ctacctggac aactggggcc aggggaccct ggtcaccgtc      360

tcctcag                                                                367


<210>  5
<211>  367
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH

<400>  5
gaagtgcagc tggtggagtc tgggggaggc ttggtccagc cgggggggtc cctgagactc       60

tcctgttcaa cgtctggatt cgactttagt aggcattgga tgacctgggt ccgacaggct      120

ccagggaagg ggctggagtg ggtggccgac ataaagaaag atggaagtga ggagaactat      180

gtggacactg tgaagggccg actcaccatc tccagagaca acgccaggag gtcactctat      240

ctgcaaatga acagcctgag aaccgacgac acggccgtgt attattgtgc gagaggaccc      300

tcgtatggtg accggagtga ctacctggac aactggggcc aggggaccct ggtcaccgtc      360

tcctcag                                                                367


<210>  6
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL

<400>  6
gatattgtga tgactcagtc tccactctcc ctgcccgtca ccccaggaga gccggcctcc       60

atctcctgca ggtctagtca gagcctcctg gagcctaatg gacacaacta tgtggattgg      120

taccagcaaa agccagggca gtctccacgg ctcctgatct atttgggttc taaccgggcc      180

tccggggtcc ctgacaggtt cagtggcagt ggaggaggca cagactttac actgaaaatc      240

agcagagtgg aggctgagga tgttgggctt tattactgca tgcaacctct gcaaactccg      300

tacacttttg gccaggggac caagctggag atcaaac                               337


<210>  7
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL

<400>  7
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgttggaga cagagtcacc       60

atcacttgcc gggccagtca gagtatcagt agctggttgg cctggtatca gcagaaacca      120

ggaaaagccc ctaagctcct gatcaataag gcgtctagtt tggaaagtgg ggtcccatca      180

agattcagcg gcagcggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct      240

gatgattttg caacttatta ctgccaacag tataatgatt attctcccgc attcggccaa      300

gggaccaagg tggagatcaa ac                                               322


<210>  8
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL

<400>  8
cagtctgtgc tgactcagcc accctcaacg tctgggaccc ccgggcagag ggtcaccatc       60

tcttgttctg gaagcagctc caacatcgga agtaaaactg tcaactggta caagcaagtc      120

ccaggaacgg cccccaaact cctcgtcttt aatgataatc aacggccctc cagggtccct      180

gaccgattct ctgggtccaa gtctggcacg tcagcctccc tggccatcag tgggctccag      240

tctgacgatg aggctgatta ttactgtgca gcgtgggatg acaacttcaa tggcctgcta      300

ttcggcggag ggaccaagct gaccgtccta                                       330


<210>  9
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL

<400>  9
gatattgtga tgactcagtc tcctctctcc ctggccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gtggctcctg gagagtaatg gacacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacaa ctcctgatcc ctttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt gggtcaggca cagattttac actgacaatc      240

agcagagtgg aggctgagga tgttggggtt tattattgca tgcaacctct aaaacttccg      300

tacacttttg gccaggggac caagctggag atcaaac                               337


<210>  10
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL

<400>  10
gatattgtga tgactcagtc tcctctctcc ctggccgtca cccctggaga gccggcctcc       60

atctcctgca ggtctagtca gtggctcctg gagagtaatg gacacaacta tttggattgg      120

tacctgcaga agccagggca gtctccacaa ctcctgatct ctttgggttc taatcgggcc      180

tccggggtcc ctgacaggtt cagtggcagt gggtcaggca cagattttac actgacaatc      240

agcagagtgg aggctgagga tgttggggtt tattattgca tgcaacctct aaaacttccg      300

tacacttttg gccaggggac caagctggag atcaaac                               337


<210>  11
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ile Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Lys Ala Asp Gly Ser Glu Lys Val Tyr Leu Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Arg Asn Leu Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Val Glu Asp Ser Ala Leu Tyr His Cys 
                85                  90                  95      


Ala Arg Gly Pro Ser Tyr Gly Asp Arg Cys Asp Tyr Leu Asp His Trp 
            100                 105                 110         


Gly Arg Gly Ala Leu Val Thr Val Ser Ser 
        115                 120         


<210>  12
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  12

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Gly Asp Gly His Ser Thr Tyr Tyr Val Glu Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Ser Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Val Asn Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Tyr Ser Ser Gly Arg Cys Gly Ser Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  13
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  13

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Ser Gly Val Ser Ile Ser Asn Phe 
            20                  25                  30          


Asn Tyr Tyr Trp Gly Trp Val Arg Gln Pro Pro Gly Lys Pro Leu Glu 
        35                  40                  45              


Trp Ile Gly Thr Ile Tyr Tyr Asn Gly Asn Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Thr Gln Leu 
65                  70                  75                  80  


Ser Leu Lys Leu Leu Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Trp Asp Ser Gly Ser Val Glu Arg Phe Asp His Trp Ser Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  14
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Thr Ser Gly Phe Asp Phe Ser Arg His 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Lys Lys Asp Gly Ser Glu Glu Asn Tyr Val Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Arg Arg Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Ser Tyr Gly Asp Arg Ser Asp Tyr Leu Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  15
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Thr Ser Gly Phe Asp Phe Ser Arg His 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Lys Lys Asp Gly Ser Glu Glu Asn Tyr Val Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Arg Arg Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Thr Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Ser Tyr Gly Asp Arg Ser Asp Tyr Leu Asp Asn Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  16
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Glu Pro 
            20                  25                  30          


Asn Gly His Asn Tyr Val Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Gly Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Leu Tyr Tyr Cys Met Gln Pro 
                85                  90                  95      


Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Asn Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Asp Tyr Ser Pro 
                85                  90                  95      


Ala Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  18
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  18

Gln Ser Val Leu Thr Gln Pro Pro Ser Thr Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys 
            20                  25                  30          


Thr Val Asn Trp Tyr Lys Gln Val Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Val Phe Asn Asp Asn Gln Arg Pro Ser Arg Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Asn Phe 
                85                  90                  95      


Asn Gly Leu Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  19
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  19

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ala Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Trp Leu Leu Glu Ser 
            20                  25                  30          


Asn Gly His Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Pro Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Pro 
                85                  90                  95      


Leu Lys Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  20
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Ala Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Trp Leu Leu Glu Ser 
            20                  25                  30          


Asn Gly His Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Ser Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Pro 
                85                  90                  95      


Leu Lys Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  21
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  21

Arg Asn Trp Met Ser 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  22

Asp Ile Lys Ala Asp Gly Ser Glu Lys Val Tyr Leu Asp Ser Met Lys 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  23

Gly Pro Ser Tyr Gly Asp Arg Cys Asp Tyr Leu Asp His 
1               5                   10              


<210>  24
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  24

Asn Tyr Ala Ile His 
1               5   


<210>  25
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  25

Ala Ile Gly Gly Asp Gly His Ser Thr Tyr Tyr Val Glu Ala Val Lys 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  26

Glu Gly Tyr Ser Ser Gly Arg Cys Gly Ser Phe Asp His 
1               5                   10              


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  27

Asn Phe Asn Tyr Tyr Trp Gly 
1               5           


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  28

Thr Ile Tyr Tyr Asn Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  29

Asp Ser Gly Ser Val Glu Arg Phe Asp His 
1               5                   10  


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  30

Arg His Trp Met Thr 
1               5   


<210>  31
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  31

Asp Ile Lys Lys Asp Gly Ser Glu Glu Asn Tyr Val Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  32

Gly Pro Ser Tyr Gly Asp Arg Ser Asp Tyr Leu Asp Asn 
1               5                   10              


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  33

Arg Ser Ser Gln Ser Leu Leu Glu Pro Asn Gly His Asn Tyr Val Asp 
1               5                   10                  15      


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  34

Leu Gly Ser Asn Arg Ala Ser 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MQPLQTPYT

<400>  35

Met Gln Pro Leu Gln Thr Pro Tyr Thr 
1               5                   


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  36

Arg Ala Ser Gln Ser Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  37
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  37

Lys Ala Ser Ser Leu Glu Ser 
1               5           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  38

Gln Gln Tyr Asn Asp Tyr Ser Pro Ala 
1               5                   


<210>  39
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  39

Ser Gly Ser Ser Ser Asn Ile Gly Ser Lys Thr Val Asn 
1               5                   10              


<210>  40
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  40

Asn Asp Asn Gln Arg Pro Ser 
1               5           


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  41

Ala Ala Trp Asp Asp Asn Phe Asn Gly Leu Leu 
1               5                   10      


<210>  42
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  42

Arg Ser Ser Gln Trp Leu Leu Glu Ser Asn Gly His Asn Tyr Leu Asp 
1               5                   10                  15      


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  43

Met Gln Pro Leu Lys Leu Pro Tyr Thr 
1               5                   


<210>  44
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  44

Gly Phe Thr Phe Ser Arg Asn Trp 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  45

Ile Lys Ala Asp Gly Ser Glu Lys 
1               5               


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  46

Ala Arg Gly Pro Ser Tyr Gly Asp Arg Cys Asp Tyr Leu Asp His 
1               5                   10                  15  


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  47

Gly Phe Thr Phe Asn Asn Tyr Ala 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  48

Ile Gly Gly Asp Gly His Ser Thr 
1               5               


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  49

Ala Arg Glu Gly Tyr Ser Ser Gly Arg Cys Gly Ser Phe Asp His 
1               5                   10                  15  


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  50

Gly Val Ser Ile Ser Asn Phe Asn Tyr Tyr 
1               5                   10  


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  51

Ile Tyr Tyr Asn Gly Asn Thr 
1               5           


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  52

Ala Trp Asp Ser Gly Ser Val Glu Arg Phe Asp His 
1               5                   10          


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  53

Gly Phe Asp Phe Ser Arg His Trp 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  54

Ile Lys Lys Asp Gly Ser Glu Glu 
1               5               


<210>  55
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  55

Ala Arg Gly Pro Ser Tyr Gly Asp Arg Ser Asp Tyr Leu Asp Asn 
1               5                   10                  15  


<210>  56
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  56

Gln Ser Leu Leu Glu Pro Asn Gly His Asn Tyr 
1               5                   10      


<210>  57
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  57

Leu Gly Ser 
1           


<210>  58
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  58

Met Gln Pro Leu Gln Thr Pro Tyr Thr 
1               5                   


<210>  59
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  59

Gln Ser Ile Ser Ser Trp 
1               5       


<210>  60
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  60

Lys Ala Ser 
1           


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  61

Gln Gln Tyr Asn Asp Tyr Ser Pro Ala 
1               5                   


<210>  62
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  62

Ser Ser Asn Ile Gly Ser Lys Thr 
1               5               


<210>  63
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  63

Asn Asp Asn 
1           


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  64

Ala Ala Trp Asp Asp Asn Phe Asn Gly Leu Leu 
1               5                   10      


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  65

Gln Trp Leu Leu Glu Ser Asn Gly His Asn Tyr 
1               5                   10      


<210>  66
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<400>  66

Met Gln Pro Leu Lys Leu Pro Tyr Thr 
1               5                   


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  67

Ala Arg Gly Pro Ser Tyr Gly Asp Arg Ser Asp Tyr Leu Asp His 
1               5                   10                  15  


<210>  68
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  68

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ile Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Lys Ala Asp Gly Ser Glu Lys Val Tyr Leu Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Arg Asn Leu Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Val Glu Asp Ser Ala Leu Tyr His Cys 
                85                  90                  95      


Ala Arg Gly Pro Ser Tyr Gly Asp Arg Ser Asp Tyr Leu Asp His Trp 
            100                 105                 110         


Gly Arg Gly Ala Leu Val Thr Val Ser Ser 
        115                 120         


<210>  69
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ile Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Lys Ala Asp Gly Ser Glu Lys Val Tyr Leu Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Arg Asn Leu Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Val Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Ser Tyr Gly Asp Arg Cys Asp Tyr Leu Asp His Trp 
            100                 105                 110         


Gly Arg Gly Ala Leu Val Thr Val Ser Ser 
        115                 120         


<210>  70
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Phe Thr Phe Ser Arg Asn 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ile Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Asp Ile Lys Ala Asp Gly Ser Glu Lys Val Tyr Leu Asp Ser Met 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ala Arg Asn Leu Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Val Glu Asp Ser Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Pro Ser Tyr Gly Asp Arg Ser Asp Tyr Leu Asp His Trp 
            100                 105                 110         


Gly Arg Gly Ala Leu Val Thr Val Ser Ser 
        115                 120         


<210>  71
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH

<400>  71
gaggtgcagc tggtggaatc tggcggagga ctggtgcagc ctggcggctc tctgagactg       60

tcttgcgagg cctccggctt caccttctcc cggaactgga tgtcctgggt gcgacagatc      120

cctggcaagg gcctggaatg ggtggccgac atcaaggccg acggctccga gaaggtgtac      180

ctggactcta tgaagggccg gctgaccatc tcccgggaca acgccagaaa cctgctgtac      240

ctgcagatgg actccctgcg ggtggaagat tccgccctgt accactgtgc cagaggcccc      300

tcttacggcg acagatccga ctacctggac cattggggca gaggcgccct cgtgacagtg      360

tcctct                                                                 366


<210>  72
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH

<400>  72
gaggtgcagc tggtggaatc tggcggagga ctggtgcagc ctggcggctc tctgagactg       60

tcttgcgagg cctccggctt caccttctcc cggaactgga tgtcctgggt gcgacagatc      120

cctggcaagg gcctggaatg ggtggccgac atcaaggccg acggctccga gaaggtgtac      180

ctggactcta tgaagggccg gctgaccatc tcccgggaca acgccagaaa cctgctgtac      240

ctgcagatgg actccctgcg ggtggaagat tccgccctgt actactgtgc cagaggcccc      300

tcttacggcg acagatgcga ctacctggac cattggggca gaggcgccct cgtgacagtg      360

tcctct                                                                 366


<210>  73
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH

<400>  73
gaggtgcagc tggtggaatc tggcggagga ctggtgcagc ctggcggctc tctgagactg       60

tcttgcgagg cctccggctt caccttctcc cggaactgga tgtcctgggt gcgacagatc      120

cctggcaagg gcctggaatg ggtggccgac atcaaggccg acggctccga gaaggtgtac      180

ctggactcta tgaagggccg gctgaccatc tcccgggaca acgccagaaa cctgctgtac      240

ctgcagatgg actccctgcg ggtggaagat tccgccctgt actactgtgc cagaggcccc      300

tcttacggcg acagatccga ctacctggac cattggggca gaggcgccct cgtgacagtg      360

tcctct                                                                 366


<210>  74
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  74

Gly Pro Ser Tyr Gly Asp Arg Ser Asp Tyr Leu Asp His 
1               5                   10              


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR1


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is T or D

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is N or H

<400>  75

Gly Phe Xaa Phe Ser Arg Xaa Trp 
1               5               


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR2


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is A or K

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is K or E

<400>  76

Ile Lys Xaa Asp Gly Ser Glu Xaa 
1               5               


<210>  77
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR3


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is C or S

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is H or N

<400>  77

Ala Arg Gly Pro Ser Tyr Gly Asp Arg Xaa Asp Tyr Leu Asp Xaa 
1               5                   10                  15  


<210>  78
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR4


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X is S or W

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is P or S

<400>  78

Gln Xaa Leu Leu Glu Xaa Asn Gly His Asn Tyr 
1               5                   10      


<210>  79
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR6


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X is Q or K

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X is T or L

<400>  79

Met Gln Pro Leu Xaa Thr Pro Tyr Thr 
1               5                   


