                               SEQUENCE LISTING

<110> NOVARTIS AG
 
<120> MRNA-MEDIATED IMMUNIZATION METHODS

<130> PAT057169-WO-PCT

<140>
<141>

<150> 62/399,544
<151> 2016-09-26

<150> 62/371,834
<151> 2016-08-07

<160> 60    

<170> PatentIn version 3.5

<210> 1
<211> 9
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence

<400> 1
gccaccatg                                                                9


<210> 2
<211> 3874
<212> RNA
<213> Homo sapiens

<400> 2
gugcgugugu guaaagaagg agauuaggac auuuagagaa ggagggcggg gaggagagau       60

ccugagaaua gaaaggagga aagaaaaaaa gaggaaugga aagagacaga gaaaggaaau      120

gggaguggaa ggagggagga cugcuuugua acugcuaaga uugcagacag aaauagcaca      180

caaccacugu gagcuguaug cgauucagaa accaagacca aauuuugcuc acuuucauua      240

aucaguugcu cagauagaag gaaaugacau cugguucugu cuucuucuac aucuuaauuu      300

uuggaaaaua uuuuucucau ggggguggac aggaugucaa gugcucccuu ggcuauuucc      360

ccugugggaa caucacaaag ugcuugccuc agcuccugca cuguaacggu guggacgacu      420

gcgggaauca ggccgaugag gacaacugug gagacaacaa uggauggucu cugcaauuug      480

acaaauauuu ugccaguuac uacaaaauga cuucccaaua uccuuuugag gcagaaacac      540

cugaauguuu ggucgguucu gugccagugc aaugucuuug ccaaggucug gagcuugacu      600

gugaugaaac caauuuacga gcuguuccau cgguuucuuc aaaugugacu gcaaugucac      660

uucaguggaa cuuaauaaga aagcuuccuc cugauugcuu caagaauuau caugaucuuc      720

agaagcugua ccugcaaaac aauaagauua cauccaucuc caucuaugcu uucagaggac      780

ugaauagccu uacuaaacug uaucucaguc auaacagaau aaccuuccug aagccgggug      840

uuuuugaaga ucuucacaga cuagaauggc ugauaauuga agauaaucac cucagucgaa      900

uuuccccacc aacauuuuau ggacuaaauu cucuuauucu cuuaguccug augaauaacg      960

uccucacccg uuuaccugau aaaccucucu gucaacacau gccaagacua cauuggcugg     1020

accuugaagg caaccauauc cauaauuuaa gaaauuugac uuuuauuucc ugcaguaauu     1080

uaacuguuuu agugaugagg aaaaacaaaa uuaaucacuu aaaugaaaau acuuuugcac     1140

cucuccagaa acuggaugaa uuggauuuag gaaguaauaa gauugaaaau cuuccaccgc     1200

uuauauucaa ggaccugaag gagcugucac aauugaaucu uuccuauaau ccaauccaga     1260

aaauucaagc aaaccaauuu gauuaucuug ucaaacucaa gucucucagc cuagaaggga     1320

uugaaauuuc aaauauccaa caaaggaugu uuagaccucu uaugaaucuc ucucacauau     1380

auuuuaagaa auuccaguac uguggguaug caccacaugu ucgcagcugu aaaccaaaca     1440

cugauggaau uucaucucua gagaaucucu uggcaagcau uauucagaga guauuugucu     1500

ggguuguauc ugcaguuacc ugcuuuggaa acauuuuugu cauuugcaug cgaccuuaua     1560

ucaggucuga gaacaagcug uaugccaugu caaucauuuc ucucugcugu gccgacugcu     1620

uaaugggaau auauuuauuc gugaucggag gcuuugaccu aaaguuucgu ggagaauaca     1680

auaagcaugc gcagcugugg auggagagua cucauuguca gcuuguagga ucuuuggcca     1740

uucuguccac agaaguauca guuuuacugu uaacauuucu gacauuggaa aaauacaucu     1800

gcauugucua uccuuuuaga ugugugagac cuggaaaaug cagaacaauu acaguucuga     1860

uucucauuug gauuacuggu uuuauagugg cuuucauucc auugagcaau aaggaauuuu     1920

ucaaaaacua cuauggcacc aauggaguau gcuucccucu ucauucagaa gauacagaaa     1980

guauuggagc ccagauuuau ucaguggcaa uuuuucuugg uauuaauuug gccgcauuua     2040

ucaucauagu uuuuuccuau ggaagcaugu uuuauagugu ucaucaaagu gccauaacag     2100

caacugaaau acggaaucaa guuaaaaaag agaugauccu ugccaaacgu uuuuucuuua     2160

uaguauuuac ugaugcauua ugcuggauac ccauuuuugu agugaaauuu cuuucacugc     2220

uucagguaga aauaccaggu accauaaccu cuuggguagu gauuuuuauu cugcccauua     2280

acagugcuuu gaacccaauu cucuauacuc ugaccacaag accauuuaaa gaaaugauuc     2340

aucgguuuug guauaacuac agacaaagaa aaucuaugga cagcaaaggu cagaaaacau     2400

augcuccauc auucaucugg guggaaaugu ggccacugca ggagaugcca ccugaguuaa     2460

ugaagccgga ccuuuucaca uaccccugug aaaugucacu gauuucucaa ucaacgagac     2520

ucaauuccua uucaugacug acucugaaau ucauuucuuc gcagagaaua cugugggggu     2580

gcuucaugag ggauuuacug guaugaaaug aauaccacaa aauuaauuua uaauaauagc     2640

uaagauaaau auuuuacaag gacaugagga aaaauaaaaa ugacuaaugc ucuuacaaag     2700

ggaaguaauu auaucaauaa uguauauaua uuaguagaca uuuugcauaa gaaauuaaga     2760

gaaaucuacu ucaguaacau ucauucauuu uucuaacaug cauuuauuga guacccacua     2820

cuaugugcau agcauugcaa uauaguccug gaaguagaca gugcagaacc uuucaaucug     2880

uagauggugu uuaaugacaa aagacuauac aaaguccauc ugcaguuccu aguuuaaagu     2940

agagcuuuac cugucaugug caucagcaag aaucauaggc acuuuuaaau aaagguuuaa     3000

aguuuuggaa uacucagugu auuugcauca uagaaaaugu cugacuguuu gcaaaauaau     3060

auucuguuuu aagaauccau cuuaccucuc uuuaaguuuc cauacacuug agagccaaca     3120

caacauauuu auuacuaaaa agaugcuuug cuagaaacuc aaaaacagca cuucuuuugg     3180

cacuuccugc ccaguuuucu cuuugcuuua aaugaacauc aucauaugga auuggaauag     3240

gagaguauga guacggcaga gaaguggauc agaaaaacua gaaugaggau aaacauuuac     3300

auuaguggaa acuccugaaa uaaauccuug uauugucagu uaacugauuu ucaacaagga     3360

ugccaagaca aaaaggcuuu ucaacaaacc gugcuguuuu aagaacagac cuaagugguu     3420

uaauucaccc acuuuagaug ggugaauguu auggugugug aaauaucuca guaaagcagu     3480

uaaaaggaaa aagagcugga augcacugau ucaggaacuu aauuucagga aggaaagguc     3540

uguauguaca cauuucacuu uaagcagaaa aucuuucuuc aagaaaugac uuuacuuucu     3600

cuuugcacug ccagcacgug agauacuaac uuuuuaacua guuguucuuc ucuagucucu     3660

acguuauuag aauuuuuugc uuucauaaug ugaaaccuuu aagcaggaga agaaaauguu     3720

uucagauagu uucaaauaca ccaaaaaugu uugaaacaca aaaauacugg aaucaaacca     3780

uaaugcacuu auugaauaua uaguuguaua gauuuguucu gaaaauaaau uaucugaaau     3840

uuaacuauua aaaaaaaaaa aaaaaaaaaa aaaa                                 3874


<210> 3
<211> 757
<212> PRT
<213> Homo sapiens

<400> 3
Met Thr Ser Gly Ser Val Phe Phe Tyr Ile Leu Ile Phe Gly Lys Tyr 
1               5                   10                  15      


Phe Ser His Gly Gly Gly Gln Asp Val Lys Cys Ser Leu Gly Tyr Phe 
            20                  25                  30          


Pro Cys Gly Asn Ile Thr Lys Cys Leu Pro Gln Leu Leu His Cys Asn 
        35                  40                  45              


Gly Val Asp Asp Cys Gly Asn Gln Ala Asp Glu Asp Asn Cys Gly Asp 
    50                  55                  60                  


Asn Asn Gly Trp Ser Leu Gln Phe Asp Lys Tyr Phe Ala Ser Tyr Tyr 
65                  70                  75                  80  


Lys Met Thr Ser Gln Tyr Pro Phe Glu Ala Glu Thr Pro Glu Cys Leu 
                85                  90                  95      


Val Gly Ser Val Pro Val Gln Cys Leu Cys Gln Gly Leu Glu Leu Asp 
            100                 105                 110         


Cys Asp Glu Thr Asn Leu Arg Ala Val Pro Ser Val Ser Ser Asn Val 
        115                 120                 125             


Thr Ala Met Ser Leu Gln Trp Asn Leu Ile Arg Lys Leu Pro Pro Asp 
    130                 135                 140                 


Cys Phe Lys Asn Tyr His Asp Leu Gln Lys Leu Tyr Leu Gln Asn Asn 
145                 150                 155                 160 


Lys Ile Thr Ser Ile Ser Ile Tyr Ala Phe Arg Gly Leu Asn Ser Leu 
                165                 170                 175     


Thr Lys Leu Tyr Leu Ser His Asn Arg Ile Thr Phe Leu Lys Pro Gly 
            180                 185                 190         


Val Phe Glu Asp Leu His Arg Leu Glu Trp Leu Ile Ile Glu Asp Asn 
        195                 200                 205             


His Leu Ser Arg Ile Ser Pro Pro Thr Phe Tyr Gly Leu Asn Ser Leu 
    210                 215                 220                 


Ile Leu Leu Val Leu Met Asn Asn Val Leu Thr Arg Leu Pro Asp Lys 
225                 230                 235                 240 


Pro Leu Cys Gln His Met Pro Arg Leu His Trp Leu Asp Leu Glu Gly 
                245                 250                 255     


Asn His Ile His Asn Leu Arg Asn Leu Thr Phe Ile Ser Cys Ser Asn 
            260                 265                 270         


Leu Thr Val Leu Val Met Arg Lys Asn Lys Ile Asn His Leu Asn Glu 
        275                 280                 285             


Asn Thr Phe Ala Pro Leu Gln Lys Leu Asp Glu Leu Asp Leu Gly Ser 
    290                 295                 300                 


Asn Lys Ile Glu Asn Leu Pro Pro Leu Ile Phe Lys Asp Leu Lys Glu 
305                 310                 315                 320 


Leu Ser Gln Leu Asn Leu Ser Tyr Asn Pro Ile Gln Lys Ile Gln Ala 
                325                 330                 335     


Asn Gln Phe Asp Tyr Leu Val Lys Leu Lys Ser Leu Ser Leu Glu Gly 
            340                 345                 350         


Ile Glu Ile Ser Asn Ile Gln Gln Arg Met Phe Arg Pro Leu Met Asn 
        355                 360                 365             


Leu Ser His Ile Tyr Phe Lys Lys Phe Gln Tyr Cys Gly Tyr Ala Pro 
    370                 375                 380                 


His Val Arg Ser Cys Lys Pro Asn Thr Asp Gly Ile Ser Ser Leu Glu 
385                 390                 395                 400 


Asn Leu Leu Ala Ser Ile Ile Gln Arg Val Phe Val Trp Val Val Ser 
                405                 410                 415     


Ala Val Thr Cys Phe Gly Asn Ile Phe Val Ile Cys Met Arg Pro Tyr 
            420                 425                 430         


Ile Arg Ser Glu Asn Lys Leu Tyr Ala Met Ser Ile Ile Ser Leu Cys 
        435                 440                 445             


Cys Ala Asp Cys Leu Met Gly Ile Tyr Leu Phe Val Ile Gly Gly Phe 
    450                 455                 460                 


Asp Leu Lys Phe Arg Gly Glu Tyr Asn Lys His Ala Gln Leu Trp Met 
465                 470                 475                 480 


Glu Ser Thr His Cys Gln Leu Val Gly Ser Leu Ala Ile Leu Ser Thr 
                485                 490                 495     


Glu Val Ser Val Leu Leu Leu Thr Phe Leu Thr Leu Glu Lys Tyr Ile 
            500                 505                 510         


Cys Ile Val Tyr Pro Phe Arg Cys Val Arg Pro Gly Lys Cys Arg Thr 
        515                 520                 525             


Ile Thr Val Leu Ile Leu Ile Trp Ile Thr Gly Phe Ile Val Ala Phe 
    530                 535                 540                 


Ile Pro Leu Ser Asn Lys Glu Phe Phe Lys Asn Tyr Tyr Gly Thr Asn 
545                 550                 555                 560 


Gly Val Cys Phe Pro Leu His Ser Glu Asp Thr Glu Ser Ile Gly Ala 
                565                 570                 575     


Gln Ile Tyr Ser Val Ala Ile Phe Leu Gly Ile Asn Leu Ala Ala Phe 
            580                 585                 590         


Ile Ile Ile Val Phe Ser Tyr Gly Ser Met Phe Tyr Ser Val His Gln 
        595                 600                 605             


Ser Ala Ile Thr Ala Thr Glu Ile Arg Asn Gln Val Lys Lys Glu Met 
    610                 615                 620                 


Ile Leu Ala Lys Arg Phe Phe Phe Ile Val Phe Thr Asp Ala Leu Cys 
625                 630                 635                 640 


Trp Ile Pro Ile Phe Val Val Lys Phe Leu Ser Leu Leu Gln Val Glu 
                645                 650                 655     


Ile Pro Gly Thr Ile Thr Ser Trp Val Val Ile Phe Ile Leu Pro Ile 
            660                 665                 670         


Asn Ser Ala Leu Asn Pro Ile Leu Tyr Thr Leu Thr Thr Arg Pro Phe 
        675                 680                 685             


Lys Glu Met Ile His Arg Phe Trp Tyr Asn Tyr Arg Gln Arg Lys Ser 
    690                 695                 700                 


Met Asp Ser Lys Gly Gln Lys Thr Tyr Ala Pro Ser Phe Ile Trp Val 
705                 710                 715                 720 


Glu Met Trp Pro Leu Gln Glu Met Pro Pro Glu Leu Met Lys Pro Asp 
                725                 730                 735     


Leu Phe Thr Tyr Pro Cys Glu Met Ser Leu Ile Ser Gln Ser Thr Arg 
            740                 745                 750         


Leu Asn Ser Tyr Ser 
        755         


<210> 4
<211> 2883
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
ggaggccgga gaauuguaau acgacucacu auagggagac gcguguuaaa uaacaaaucu       60

caacacaaca uauacaaaac aaacgaaucu caagcaauca agcauucuac uucuauugca      120

gcaauuuaaa ucauuucuuu uaaagcaaaa gcaauuuucu gaaaauuuuc accauuuacg      180

aacgauagcc gccaccauga caagcggcag cguguucuuc uacauccuga ucuucggcaa      240

guacuucagc cacggcggag gccaggacgu gaaguguagc cugggcuacu uccccugcgg      300

caacaucacc aagugccugc cccagcugcu gcacugcaac ggcguggacg auugcggcaa      360

ccaggccgac gaggacaacu gcggcgacaa caauggcugg ucccugcagu ucgauaagua      420

cuucgccucc uacuacaaga ugaccagcca guaccccuuc gaggccgaga caccugagug      480

ccucgugggc ucugugccug ugcagugucu gugccagggc cuggaacugg acugcgacga      540

gacaaaccug agagccgugc ccagcguguc cagcaacgug acagccauga gccugcagug      600

gaaccugauc cggaagcugc cccccgacug cuucaagaac uaccacgacc ugcagaagcu      660

guaucugcag aacaacaaga ucaccuccau cagcaucuac gccuuccggg gccugaacag      720

ccugaccaag cuguaccuga gccacaaccg gaucaccuuu cugaagcccg gcguguucga      780

ggaccugcac agacuggaau ggcugaucau cgaggacaau caccugagcc ggaucagccc      840

ccccaccuuc uacggccuga acucccugau ccugcuggug cugaugaaca acgugcugac      900

ccggcugccc gacaagcccc ugugucagca caugcccaga cugcacuggc uggaccugga      960

aggcaaccac auccacaacc ugcggaaccu gaccuucauc agcugcagca accugaccgu     1020

gcucgugaug cggaagaaca agauuaacca ccugaacgag aacaccuucg ccccccugca     1080

gaaacuggac gagcuggauc ugggcucuaa caagaucgag aaccugcccc cucugaucuu     1140

caaggaccug aaagagcuga gccagcugaa ccuguccuac aaccccaucc agaagaucca     1200

ggccaaccag uucgacuacc ucgugaagcu gaagucccug ucccuggaag ggaucgagau     1260

cagcaacauc cagcagcgga uguuccggcc ccugaugaau cugucccaca ucuacuucaa     1320

gaaguuccag uacugcggcu acgcccccca cgugcggagc ugcaagccua acacagacgg     1380

caucagcagc cuggaaaacc ugcuggccuc caucauccag cggguguucg uguggguggu     1440

guccgccgug accugcuucg gcaauaucuu cgugaucugc augcggcccu acauucggag     1500

cgagaacaag cuguaugcca ugagcaucau cucccugugc ugcgccgacu gccugauggg     1560

caucuaccug uucgugaucg gcggcuucga ccugaaguuc cggggcgagu acaacaagca     1620

cgcccagcug uggauggaaa gcacccacug ccagcucgug ggcagccugg ccauccugag     1680

cacugaagug uccgugcugc ugcugaccuu ccugacccug gaaaaguaca ucugcaucgu     1740

guacccuuuc agaugcgugc ggccuggcaa gugccggacc aucacagugc ugauccugau     1800

uuggaucacc ggcuucaucg uggccuucau cccccugagc aacaaagagu ucuucaagaa     1860

uuacuacggc accaauggcg ugugcuuccc acugcacucc gaggacacag agagcaucgg     1920

cgcccagauc uacagcgugg ccaucuuccu gggcaucaau cuggccgccu ucaucaucau     1980

cguguucagc uacggcucca uguucuacuc cgugcaccag agcgccauca ccgccaccga     2040

gauccggaac caagugaaga aagagaugau ccuggccaag cgcuucuucu ucauuguguu     2100

caccgacgcc cuguguugga uuccaaucuu cgucgugaag uuccugagcc ugcugcaggu     2160

ggaaaucccc ggcacaauca ccagcugggu cgugaucuuc auccugccca ucaacagcgc     2220

ccugaacccu auccuguaca cccugaccac ccggcccuuc aaagaaauga uccaccgguu     2280

cugguacaac uaccggcaga gaaagagcau ggacagcaag ggccagaaaa ccuacgcccc     2340

uagcuucauc uggguggaaa uguggccacu gcaggaaaug ccucccgaac ugaugaagcc     2400

cgaccuguuc accuaccccu gcgagaugag ccugaucucc cagagcaccc ggcugaacag     2460

cuacuccuga uaacggaccg gcgauagaug aagcucgcuu ucuugcuguc caauuucuau     2520

uaaagguucc uuuguucccu aaguccaacu acuaaacugg gggauauuau gaagggccuu     2580

gagcaucugg auucugccua auaaaaaaca uuuauuuuca uugcagcucg cuuucuugcu     2640

guccaauuuc uauuaaaggu uccuuuguuc ccuaagucca acuacuaaac ugggggauau     2700

uaugaagggc cuugagcauc uggauucugc cuaauaaaaa acauuuauuu ucauugcggc     2760

cgcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2820

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2880

aaa                                                                   2883


<210> 5
<211> 1786
<212> RNA
<213> Homo sapiens

<400> 5
gggcgggacu uccggucgug ggccaugccg ggggcgggcc cggaaccgcc acggcuagaa       60

gaagucuuca cuucccagga gagccaaagc gugucuggcc cuagguggga aaagaacugg      120

cugugaccuu ugcccugacc uggaagggcc cagccuuggg cugaauggca gcacccacgc      180

ccgcccgucc ggugcugacc caccugcugg uggcucucuu cggcaugggc uccugggcug      240

cggucaaugg gaucugggug gagcuaccug ugguggucaa agagcuucca gaggguugga      300

gccuccccuc uuacgucucu gugcuugugg cucuggggaa ccugggucug cuggugguga      360

cccucuggag gaggcuggcc ccaggaaagg acgagcaggu ccccauccgg guggugcagg      420

ugcugggcau ggugggcaca gcccugcugg ccucucugug gcaccaugug gccccagugg      480

caggacaguu gcauucugug gccuucuuag cacuggccuu ugugcuggca cuggcaugcu      540

gugccucgaa ugucacuuuc cugcccuucu ugagccaccu gccaccucgc uucuuacggu      600

cauucuuccu gggucaaggc cugagugccc ugcugcccug cgugcuggcc cuagugcagg      660

gugugggccg ccucgagugc ccgccagccc ccaucaacgg caccccuggc cccccgcucg      720

acuuccuuga gcguuuuccc gccagcaccu ucuucugggc acugacugcc cuucuggucg      780

cuucagcugc ugccuuccag ggucuucugc ugcuguugcc gccaccacca ucuguaccca      840

caggggaguu aggaucaggc cuccaggugg gagccccagg agcagaggaa gagguggaag      900

aguccucacc acugcaagag ccaccaagcc aggcagcagg caccaccccu gguccagacc      960

cuaaggccua ucagcuucua ucagcccgca gugccugccu gcugggccug uuggccgcca     1020

ccaacgcgcu gaccaauggc gugcugccug ccgugcagag cuuuuccugc uuacccuacg     1080

ggcgucuggc cuaccaccug gcuguggugc ugggcagugc ugccaauccc cuggccugcu     1140

uccuggccau gggugugcug ugcagguccu uggcagggcu gggcggccuc ucucugcugg     1200

gcguguucug ugggggcuac cugauggcgc uggcaguccu gagccccugc ccgccccugg     1260

ugggcaccuc ggcgggggug guccucgugg ugcugucgug ggugcugugu cuuggcgugu     1320

ucuccuacgu gaagguggca gccagcuccc ugcugcaugg cgggggccgg ccggcauugc     1380

uggcagccgg cguggccauc caggugggcu cucugcucgg cgcuguugcu auguuccccc     1440

cgaccagcau cuaucacgug uuccacagca gaaaggacug ugcagacccc ugugacuccu     1500

gagccugggc agguggggac cccgcucccc aacaccuguc uuucccucaa ugcugccacc     1560

augccugagu gccugcagcc caggaggccc gcacaccggu acacucgugg acaccuacac     1620

acuccauagg agauccuggc uuuccagggu gggcaagggc aaggagcagg cuuggagcca     1680

gggaccagug ggggcuguag gguaagcccc ugagccuggg accuacaugu gguuugcgua     1740

auaaaacauu uguauuuaau gaguuggcau uaaaaaaaaa aaaaaa                    1786


<210> 6
<211> 445
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Ala Pro Thr Pro Ala Arg Pro Val Leu Thr His Leu Leu Val 
1               5                   10                  15      


Ala Leu Phe Gly Met Gly Ser Trp Ala Ala Val Asn Gly Ile Trp Val 
            20                  25                  30          


Glu Leu Pro Val Val Val Lys Glu Leu Pro Glu Gly Trp Ser Leu Pro 
        35                  40                  45              


Ser Tyr Val Ser Val Leu Val Ala Leu Gly Asn Leu Gly Leu Leu Val 
    50                  55                  60                  


Val Thr Leu Trp Arg Arg Leu Ala Pro Gly Lys Asp Glu Gln Val Pro 
65                  70                  75                  80  


Ile Arg Val Val Gln Val Leu Gly Met Val Gly Thr Ala Leu Leu Ala 
                85                  90                  95      


Ser Leu Trp His His Val Ala Pro Val Ala Gly Gln Leu His Ser Val 
            100                 105                 110         


Ala Phe Leu Ala Leu Ala Phe Val Leu Ala Leu Ala Cys Cys Ala Ser 
        115                 120                 125             


Asn Val Thr Phe Leu Pro Phe Leu Ser His Leu Pro Pro Arg Phe Leu 
    130                 135                 140                 


Arg Ser Phe Phe Leu Gly Gln Gly Leu Ser Ala Leu Leu Pro Cys Val 
145                 150                 155                 160 


Leu Ala Leu Val Gln Gly Val Gly Arg Leu Glu Cys Pro Pro Ala Pro 
                165                 170                 175     


Ile Asn Gly Thr Pro Gly Pro Pro Leu Asp Phe Leu Glu Arg Phe Pro 
            180                 185                 190         


Ala Ser Thr Phe Phe Trp Ala Leu Thr Ala Leu Leu Val Ala Ser Ala 
        195                 200                 205             


Ala Ala Phe Gln Gly Leu Leu Leu Leu Leu Pro Pro Pro Pro Ser Val 
    210                 215                 220                 


Pro Thr Gly Glu Leu Gly Ser Gly Leu Gln Val Gly Ala Pro Gly Ala 
225                 230                 235                 240 


Glu Glu Glu Val Glu Glu Ser Ser Pro Leu Gln Glu Pro Pro Ser Gln 
                245                 250                 255     


Ala Ala Gly Thr Thr Pro Gly Pro Asp Pro Lys Ala Tyr Gln Leu Leu 
            260                 265                 270         


Ser Ala Arg Ser Ala Cys Leu Leu Gly Leu Leu Ala Ala Thr Asn Ala 
        275                 280                 285             


Leu Thr Asn Gly Val Leu Pro Ala Val Gln Ser Phe Ser Cys Leu Pro 
    290                 295                 300                 


Tyr Gly Arg Leu Ala Tyr His Leu Ala Val Val Leu Gly Ser Ala Ala 
305                 310                 315                 320 


Asn Pro Leu Ala Cys Phe Leu Ala Met Gly Val Leu Cys Arg Ser Leu 
                325                 330                 335     


Ala Gly Leu Gly Gly Leu Ser Leu Leu Gly Val Phe Cys Gly Gly Tyr 
            340                 345                 350         


Leu Met Ala Leu Ala Val Leu Ser Pro Cys Pro Pro Leu Val Gly Thr 
        355                 360                 365             


Ser Ala Gly Val Val Leu Val Val Leu Ser Trp Val Leu Cys Leu Gly 
    370                 375                 380                 


Val Phe Ser Tyr Val Lys Val Ala Ala Ser Ser Leu Leu His Gly Gly 
385                 390                 395                 400 


Gly Arg Pro Ala Leu Leu Ala Ala Gly Val Ala Ile Gln Val Gly Ser 
                405                 410                 415     


Leu Leu Gly Ala Val Ala Met Phe Pro Pro Thr Ser Ile Tyr His Val 
            420                 425                 430         


Phe His Ser Arg Lys Asp Cys Ala Asp Pro Cys Asp Ser 
        435                 440                 445 


<210> 7
<211> 1911
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
gggagacgcg uguuaaauaa caaaucucaa cacaacauau acaaaacaaa cgaaucucaa       60

gcaaucaagc auucuacuuc uauugcagca auuuaaauca uuucuuuuaa agcaaaagca      120

auuuucugaa aauuuucacc auuuacgaac gauagccgcc accauggcag cacccacgcc      180

cgcccguccg gugcugaccc accugcuggu ggcucucuuc ggcaugggcu ccugggcugc      240

ggucaauggg aucugggugg agcuaccugu gguggucaaa gagcuuccag aggguuggag      300

ccuccccucu uacgucucug ugcuuguggc ucuggggaac cugggucugc ugguggugac      360

ccucuggagg aggcuggccc caggaaagga cgagcagguc cccauccggg uggugcaggu      420

gcugggcaug gugggcacag cccugcuggc cucucugugg caccaugugg ccccaguggc      480

aggacaguug cauucugugg ccuucuuagc acuggccuuu gugcuggcac uggcaugcug      540

ugccucgaau gucacuuucc ugcccuucuu gagccaccug ccaccucgcu ucuuacgguc      600

auucuuccug ggucaaggcc ugagugcccu gcugcccugc gugcuggccc uagugcaggg      660

ugugggccgc cucgagugcc cgccagcccc caucaacggc accccuggcc ccccgcucga      720

cuuccuugag cguuuucccg ccagcaccuu cuucugggca cugacugccc uucuggucgc      780

uucagcugcu gccuuccagg gucuucugcu gcuguugccg ccaccaccau cuguacccac      840

aggggaguua ggaucaggcc uccagguggg agccccagga gcagaggaag agguggaaga      900

guccucacca cugcaagagc caccaagcca ggcagcaggc accaccccug guccagaccc      960

uaaggccuau cagcuucuau cagcccgcag ugccugccug cugggccugu uggccgccac     1020

caacgcgcug accaauggcg ugcugccugc cgugcagagc uuuuccugcu uacccuacgg     1080

gcgucuggcc uaccaccugg cuguggugcu gggcagugcu gccaaucccc uggccugcuu     1140

ccuggcaaug ggugugcugu gcagguccuu ggcagggcug ggcggccucu cucugcuggg     1200

cguguucugu gggggcuacc ugauggcgcu ggcaguccug agccccugcc cgccccuggu     1260

gggcaccucg gcgggggugg uccucguggu gcugucgugg gugcuguguc uuggcguguu     1320

cuccuacgug aagguggcag ccagcucccu gcugcauggc gggggccggc cggcauugcu     1380

ggcagccggc guggccaucc aggugggcuc ucugcucggc gcuguugcua uguucccccc     1440

gaccagcauc uaucacgugu uccacagcag aaaggacugu gcagaccccu gugacuccug     1500

acggaccggc gauagaugaa gcucgcuuuc uugcugucca auuucuauua aagguuccuu     1560

uguucccuaa guccaacuac uaaacugggg gauauuauga agggccuuga gcaucuggau     1620

ucugccuaau aaaaaacauu uauuuucauu gcagcucgcu uucuugcugu ccaauuucua     1680

uuaaagguuc cuuuguuccc uaaguccaac uacuaaacug ggggauauua ugaagggccu     1740

ugagcaucug gauucugccu aauaaaaaac auuuauuuuc auugcggccg caaaaaaaaa     1800

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a              1911


<210> 8
<211> 888
<212> RNA
<213> Homo sapiens

<400> 8
auaccuuaga cccucaguca ugccagugcc ugcucugugc cugcucuggg cccuggcaau       60

ggugacccgg ccugccucag cggcccccau gggcggccca gaacuggcac agcaugagga      120

gcugacccug cucuuccaug ggacccugca gcugggccag gcccucaacg guguguacag      180

gaccacggag ggacggcuga caaaggccag gaacagccug ggucucuaug gccgcacaau      240

agaacuccug gggcaggagg ucagccgggg ccgggaugca gcccaggaac uucgggcaag      300

ccuguuggag acucagaugg aggaggauau ucugcagcug caggcagagg ccacagcuga      360

ggugcugggg gagguggccc aggcacagaa ggugcuacgg gacagcgugc agcggcuaga      420

aguccagcug aggagcgccu ggcugggccc ugccuaccga gaauuugagg ucuuaaaggc      480

ucacgcugac aagcagagcc acauccuaug ggcccucaca ggccacgugc agcggcagag      540

gcgggagaug guggcacagc agcaucggcu gcgacagauc caggagagac uccacacagc      600

ggcgcuccca gccugaaucu gccuggaugg aacugaggac caaucaugcu gcaaggaaca      660

cuuccacgcc ccgugaggcc ccugugcagg gaggagcugc cuguucacug ggaucagcca      720

gggcgccggg ccccacuucu gagcacagag cagagacaga cgcaggcggg gacaaaggca      780

gaggauguag ccccauuggg gaggggugga ggaaggacau guacccuuuc augccuacac      840

accccucauu aaagcagagu cguggcaucu caaaaaaaaa aaaaaaaa                   888


<210> 9
<211> 198
<212> PRT
<213> Homo sapiens

<400> 9
Met Pro Val Pro Ala Leu Cys Leu Leu Trp Ala Leu Ala Met Val Thr 
1               5                   10                  15      


Arg Pro Ala Ser Ala Ala Pro Met Gly Gly Pro Glu Leu Ala Gln His 
            20                  25                  30          


Glu Glu Leu Thr Leu Leu Phe His Gly Thr Leu Gln Leu Gly Gln Ala 
        35                  40                  45              


Leu Asn Gly Val Tyr Arg Thr Thr Glu Gly Arg Leu Thr Lys Ala Arg 
    50                  55                  60                  


Asn Ser Leu Gly Leu Tyr Gly Arg Thr Ile Glu Leu Leu Gly Gln Glu 
65                  70                  75                  80  


Val Ser Arg Gly Arg Asp Ala Ala Gln Glu Leu Arg Ala Ser Leu Leu 
                85                  90                  95      


Glu Thr Gln Met Glu Glu Asp Ile Leu Gln Leu Gln Ala Glu Ala Thr 
            100                 105                 110         


Ala Glu Val Leu Gly Glu Val Ala Gln Ala Gln Lys Val Leu Arg Asp 
        115                 120                 125             


Ser Val Gln Arg Leu Glu Val Gln Leu Arg Ser Ala Trp Leu Gly Pro 
    130                 135                 140                 


Ala Tyr Arg Glu Phe Glu Val Leu Lys Ala His Ala Asp Lys Gln Ser 
145                 150                 155                 160 


His Ile Leu Trp Ala Leu Thr Gly His Val Gln Arg Gln Arg Arg Glu 
                165                 170                 175     


Met Val Ala Gln Gln His Arg Leu Arg Gln Ile Gln Glu Arg Leu His 
            180                 185                 190         


Thr Ala Ala Leu Pro Ala 
        195             


<210> 10
<211> 1266
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
gggagacgcg uguuaaauaa caaaucucaa cacaacauau acaaaacaaa cgaaucucaa       60

gcaaucaagc auucuacuuc uauugcagca auuuaaauca uuucuuuuaa agcaaaagca      120

auuuucugaa aauuuucacc auuuacgaac gauagccgcc accaugaaga ccuucauccu      180

gcugcugugg gugcugcugc ugugggucau cuuccugcug ccuggcgcca cagccgcucc      240

uaugggagga ccugaacugg cccagcacga ggaacugacc cugcuguuuc acggcacccu      300

gcagcuggga caggcccuga auggcgugua cagaaccacc gagggccggc ugaccaaggc      360

cagaaauagc cugggccugu acggccggac caucgaacug cuggggcagg aaguguccag      420

aggcagagau gccgcccagg aacugagagc cagccugcug gaaacccaga uggaagagga      480

cauccugcag cugcaggccg aggccacagc ugaggugcug ggagaagugg cccaggccca      540

gaaggugcug agagacagcg ugcagcggcu ggaagugcag cugagaucug ccuggcuggg      600

cccugccuac cgcgaguucg aagugcugaa agcccacgcc gacaagcaga gccacauccu      660

gugggcccug acaggccacg ugcagagaca gaggcgggaa augguggcuc agcagcacag      720

acugcggcag auccaggaac ggcugcauac agcugcccug cccgccgacu acaaggacga      780

cgacgacaag caccaccacc aucaccacgg cggaggccug aacgacaucu ucgaagccca      840

gaaaaucgag uggcacgagu aacggaccgg cgauagauga agcucgcuuu cuugcugucc      900

aauuucuauu aaagguuccu uuguucccua aguccaacua cuaaacuggg ggauauuaug      960

aagggccuug agcaucugga uucugccuaa uaaaaaacau uuauuuucau ugcagcucgc     1020

uuucuugcug uccaauuucu auuaaagguu ccuuuguucc cuaaguccaa cuacuaaacu     1080

gggggauauu augaagggcc uugagcaucu ggauucugcc uaauaaaaaa cauuuauuuu     1140

cauugcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaa                                                                1266


<210> 11
<211> 9
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence

<400> 11
gccaccaug                                                                9


<210> 12
<211> 13
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence

<400> 12
gccgccrcca ugg                                                          13


<210> 13
<211> 8
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence


<220>
<221> modified_base
<222> (3)..(4)
<223> a, g, c or u

<220>
<221> modified_base
<222> (8)..(8)
<223> a, g, c or u

<400> 13
agnnaugn                                                                 8


<210> 14
<211> 4410
<212> RNA
<213> Homo sapiens

<400> 14
ccuccuccac aguggugagg ucacagcccc uuggagcccu cccucuuccc accccucccg       60

cucccggguc uccuuuggcc ugggguaacc cgaggugcag agcugagaau gaggcgauuu      120

cggaggaugg agaaauagcc ccgagucccg uggaaaauga ggccggcgga cuugcugcag      180

cuggugcugc ugcucgaccu gcccagggac cugggcggaa ugggguguuc gucuccaccc      240

ugcgagugcc aucaggagga ggacuucaga gucaccugca aggauauuca acgcaucccc      300

agcuuaccgc ccaguacgca gacucugaag cuuauugaga cucaccugag aacuauucca      360

agucaugcau uuucuaaucu gcccaauauu uccagaaucu acguaucuau agaugugacu      420

cugcagcagc uggaaucaca cuccuucuac aauuugagua aagugacuca cauagaaauu      480

cggaauacca ggaacuuaac uuacauagac ccugaugccc ucaaagagcu cccccuccua      540

aaguuccuug gcauuuucaa cacuggacuu aaaauguucc cugaccugac caaaguuuau      600

uccacugaua uauucuuuau acuugaaauu acagacaacc cuuacaugac gucaaucccu      660

gugaaugcuu uucagggacu augcaaugaa accuugacac ugaagcugua caacaauggc      720

uuuacuucag uccaaggaua ugcuuucaau gggacaaagc uggaugcugu uuaccuaaac      780

aagaauaaau accugacagu uauugacaaa gaugcauuug gaggaguaua caguggacca      840

agcuugcugg acgugucuca aaccaguguc acugcccuuc cauccaaagg ccuggagcac      900

cugaaggaac ugauagcaag aaacaccugg acucuuaaga aacuuccacu uuccuugagu      960

uuccuucacc ucacacgggc ugaccuuucu uacccaagcc acugcugugc uuuuaagaau     1020

cagaagaaaa ucagaggaau ccuugagucc uugaugugua augagagcag uaugcagagc     1080

uugcgccaga gaaaaucugu gaaugccuug aauagccccc uccaccagga auaugaagag     1140

aaucugggug acagcauugu uggguacaag gaaaagucca aguuccagga uacucauaac     1200

aacgcucauu auuacgucuu cuuugaagaa caagaggaug agaucauugg uuuuggccag     1260

gagcucaaaa acccccagga agagacucua caagcuuuug acagccauua ugacuacacc     1320

auaugugggg acagugaaga cauggugugu acccccaagu ccgaugaguu caacccgugu     1380

gaagacauaa ugggcuacaa guuccugaga auuguggugu gguucguuag ucugcuggcu     1440

cuccugggca augucuuugu ccugcuuauu cuccucacca gccacuacaa acugaacguc     1500

ccccgcuuuc ucaugugcaa ccuggccuuu gcggauuucu gcauggggau guaccugcuc     1560

cucaucgccu cuguagaccu cuacacucac ucugaguacu acaaccaugc caucgacugg     1620

cagacaggcc cugggugcaa cacggcuggu uucuucacug ucuuugcaag cgaguuaucg     1680

guguauacgc ugacggucau cacccuggag cgcugguaug ccaucaccuu cgccaugcgc     1740

cuggaccgga agauccgccu caggcacgca ugugccauca ugguuggggg cuggguuugc     1800

ugcuuccuuc ucgcccugcu uccuuuggug ggaauaagua gcuaugccaa agucaguauc     1860

ugccugccca uggacaccga gaccccucuu gcucuggcau auauuguuuu uguucugacg     1920

cucaacauag uugccuucgu caucgucugc ugcuguuaug ugaagaucua caucacaguc     1980

cgaaauccgc aguacaaccc aggggacaaa gauaccaaaa uugccaagag gauggcugug     2040

uugaucuuca ccgacuucau augcauggcc ccaaucucau ucuaugcucu gucagcaauu     2100

cugaacaagc cucucaucac uguuagcaac uccaaaaucu ugcugguacu cuucuaucca     2160

cuuaacuccu gugccaaucc auuccucuau gcuauuuuca ccaaggccuu ccagagggau     2220

guguucaucc uacucagcaa guuuggcauc uguaaacgcc aggcucaggc auaccggggg     2280

cagaggguuc cuccaaagaa cagcacugau auucagguuc aaaagguuac ccacgagaug     2340

aggcaggguc uccacaacau ggaagauguc uaugaacuga uugaaaacuc ccaucuaacc     2400

ccaaagaagc aaggccaaau cucagaagag uauaugcaaa cgguuuugua aguuaacacu     2460

acacuacuca caaugguagg ggaacuuaca aaauaauagu uucuugaaua ugcauuccaa     2520

ucccaugaca cccccaacac auagcugccc ucacucuugu gcaggcgaug uuucaauguu     2580

ucauggggca agaguuuauc ucuggagagu gauuaguauu aaccuaauca uugcccccaa     2640

gaaggaaguu aggcuaccag cauauuugaa ugccagguga aaucaaaaua aucuacacua     2700

ucuagaagac uuucuugaug ccaaguccag agaugucauu guguaggaug uucaguaaau     2760

auuaacugag cuaugucaau auagagcuuc ucaguuuugu auaacauuuc auacuaaaga     2820

uucagcaaau ggaaaaugcu auuaauuugg uuggugacca caagauaaaa ucagucccac     2880

guuggcucag uucaacuaga uguucccuga uacaaagaga acuugauuuc cuuaaaacug     2940

aaaagccaaa cacagcuagc ugucauacaa gaaacagcua uuaugagaca ugaaggaggg     3000

uaagaauuag cuuuaaguuu uguuuugcuu uguuuuguuu uuuaacucaa ccuauuaauc     3060

aucucuucac aagaauccac cugaugugac caagcuauua uguguugccu ggaaaaacug     3120

gcaagauuuc agcuuaugug gccuagcaaa cuaagaauug cucuucuugg ccagccucau     3180

agcauaaaag augugaacuc uaggaagucu uucugaguag caauaagugg gaauuauggg     3240

cagagcacac ucaauccccu guugauuaau aaaacaggcu ggacacuaau uaacuauggg     3300

acuuaaaucu guagaaauga aggaguccaa uagcuucuuc caauuuuaaa acucuaguac     3360

aucccuuucc cucaaauaua uauuucuaag auaaagagaa agaagagcac uaaguaagua     3420

gaaucuguuu uuccuauuuu guagggcugc ugacuccuag uccuugaagc cuagacacau     3480

gacccaggaa auuuuuccuu uguuucacuu uugauuauga ugucugagcc aaaaauucaa     3540

uuaaguaaac auacucgccu ggaucugaau cauucauuua auuacuagau cuacccagcu     3600

guuauaucag gccaaaaaca gauucguguu uauauaaaag aguaaacgau gguugcaaau     3660

uuuggcuauu uagaguugcu acuucacuau gaagagucac uucaaaacac uucgcuuguc     3720

uuuagggaug auuuuugcca uuuccagucc acgguaugau acuaaagcug ucaagagagg     3780

uuucuucuuu ucugaaacug ccagcucuuu ccagcccugu ugaucacugg acauaaagcu     3840

ucuuuucccc aauaauucuu cuuuacuuaa aauagucagg aucuuuaucu acagauguac     3900

ucuccagguu accugugaug auagcccccu aauguccugc uagaaaaguc uccaagcaga     3960

gaugacauua cuucugaaug cucauaaacc acaccaugaa auaaaagcuc uuuguuguuu     4020

uaagauugug aagugucguu aauggguccc cacagauggu cccugcugga cucaccugga     4080

aucucuccac agccauaccc acucaucacu aucauugaga ccugcacauc uuaauagaaa     4140

uauuauaaac aucgaaaauc augacuuacc uagaaguucg cuuguaacua augaaauuaa     4200

acaaaugugu ugccuuuugu cauguguuuc ucuccuguga cauuucaaaa uaucacaucu     4260

ugauaaauaa uguguuucau cuugaauagc ugaacuaauu gcuuuggaaa cagaguccua     4320

gaaaagugac uucaacagaa uuguuacuaa aauuugcacu cacaacauga aauaaauuuu     4380

cuuccuaugg aauaaucgug aaaaaaaaaa                                      4410


<210> 15
<211> 764
<212> PRT
<213> Homo sapiens

<400> 15
Met Arg Pro Ala Asp Leu Leu Gln Leu Val Leu Leu Leu Asp Leu Pro 
1               5                   10                  15      


Arg Asp Leu Gly Gly Met Gly Cys Ser Ser Pro Pro Cys Glu Cys His 
            20                  25                  30          


Gln Glu Glu Asp Phe Arg Val Thr Cys Lys Asp Ile Gln Arg Ile Pro 
        35                  40                  45              


Ser Leu Pro Pro Ser Thr Gln Thr Leu Lys Leu Ile Glu Thr His Leu 
    50                  55                  60                  


Arg Thr Ile Pro Ser His Ala Phe Ser Asn Leu Pro Asn Ile Ser Arg 
65                  70                  75                  80  


Ile Tyr Val Ser Ile Asp Val Thr Leu Gln Gln Leu Glu Ser His Ser 
                85                  90                  95      


Phe Tyr Asn Leu Ser Lys Val Thr His Ile Glu Ile Arg Asn Thr Arg 
            100                 105                 110         


Asn Leu Thr Tyr Ile Asp Pro Asp Ala Leu Lys Glu Leu Pro Leu Leu 
        115                 120                 125             


Lys Phe Leu Gly Ile Phe Asn Thr Gly Leu Lys Met Phe Pro Asp Leu 
    130                 135                 140                 


Thr Lys Val Tyr Ser Thr Asp Ile Phe Phe Ile Leu Glu Ile Thr Asp 
145                 150                 155                 160 


Asn Pro Tyr Met Thr Ser Ile Pro Val Asn Ala Phe Gln Gly Leu Cys 
                165                 170                 175     


Asn Glu Thr Leu Thr Leu Lys Leu Tyr Asn Asn Gly Phe Thr Ser Val 
            180                 185                 190         


Gln Gly Tyr Ala Phe Asn Gly Thr Lys Leu Asp Ala Val Tyr Leu Asn 
        195                 200                 205             


Lys Asn Lys Tyr Leu Thr Val Ile Asp Lys Asp Ala Phe Gly Gly Val 
    210                 215                 220                 


Tyr Ser Gly Pro Ser Leu Leu Asp Val Ser Gln Thr Ser Val Thr Ala 
225                 230                 235                 240 


Leu Pro Ser Lys Gly Leu Glu His Leu Lys Glu Leu Ile Ala Arg Asn 
                245                 250                 255     


Thr Trp Thr Leu Lys Lys Leu Pro Leu Ser Leu Ser Phe Leu His Leu 
            260                 265                 270         


Thr Arg Ala Asp Leu Ser Tyr Pro Ser His Cys Cys Ala Phe Lys Asn 
        275                 280                 285             


Gln Lys Lys Ile Arg Gly Ile Leu Glu Ser Leu Met Cys Asn Glu Ser 
    290                 295                 300                 


Ser Met Gln Ser Leu Arg Gln Arg Lys Ser Val Asn Ala Leu Asn Ser 
305                 310                 315                 320 


Pro Leu His Gln Glu Tyr Glu Glu Asn Leu Gly Asp Ser Ile Val Gly 
                325                 330                 335     


Tyr Lys Glu Lys Ser Lys Phe Gln Asp Thr His Asn Asn Ala His Tyr 
            340                 345                 350         


Tyr Val Phe Phe Glu Glu Gln Glu Asp Glu Ile Ile Gly Phe Gly Gln 
        355                 360                 365             


Glu Leu Lys Asn Pro Gln Glu Glu Thr Leu Gln Ala Phe Asp Ser His 
    370                 375                 380                 


Tyr Asp Tyr Thr Ile Cys Gly Asp Ser Glu Asp Met Val Cys Thr Pro 
385                 390                 395                 400 


Lys Ser Asp Glu Phe Asn Pro Cys Glu Asp Ile Met Gly Tyr Lys Phe 
                405                 410                 415     


Leu Arg Ile Val Val Trp Phe Val Ser Leu Leu Ala Leu Leu Gly Asn 
            420                 425                 430         


Val Phe Val Leu Leu Ile Leu Leu Thr Ser His Tyr Lys Leu Asn Val 
        435                 440                 445             


Pro Arg Phe Leu Met Cys Asn Leu Ala Phe Ala Asp Phe Cys Met Gly 
    450                 455                 460                 


Met Tyr Leu Leu Leu Ile Ala Ser Val Asp Leu Tyr Thr His Ser Glu 
465                 470                 475                 480 


Tyr Tyr Asn His Ala Ile Asp Trp Gln Thr Gly Pro Gly Cys Asn Thr 
                485                 490                 495     


Ala Gly Phe Phe Thr Val Phe Ala Ser Glu Leu Ser Val Tyr Thr Leu 
            500                 505                 510         


Thr Val Ile Thr Leu Glu Arg Trp Tyr Ala Ile Thr Phe Ala Met Arg 
        515                 520                 525             


Leu Asp Arg Lys Ile Arg Leu Arg His Ala Cys Ala Ile Met Val Gly 
    530                 535                 540                 


Gly Trp Val Cys Cys Phe Leu Leu Ala Leu Leu Pro Leu Val Gly Ile 
545                 550                 555                 560 


Ser Ser Tyr Ala Lys Val Ser Ile Cys Leu Pro Met Asp Thr Glu Thr 
                565                 570                 575     


Pro Leu Ala Leu Ala Tyr Ile Val Phe Val Leu Thr Leu Asn Ile Val 
            580                 585                 590         


Ala Phe Val Ile Val Cys Cys Cys Tyr Val Lys Ile Tyr Ile Thr Val 
        595                 600                 605             


Arg Asn Pro Gln Tyr Asn Pro Gly Asp Lys Asp Thr Lys Ile Ala Lys 
    610                 615                 620                 


Arg Met Ala Val Leu Ile Phe Thr Asp Phe Ile Cys Met Ala Pro Ile 
625                 630                 635                 640 


Ser Phe Tyr Ala Leu Ser Ala Ile Leu Asn Lys Pro Leu Ile Thr Val 
                645                 650                 655     


Ser Asn Ser Lys Ile Leu Leu Val Leu Phe Tyr Pro Leu Asn Ser Cys 
            660                 665                 670         


Ala Asn Pro Phe Leu Tyr Ala Ile Phe Thr Lys Ala Phe Gln Arg Asp 
        675                 680                 685             


Val Phe Ile Leu Leu Ser Lys Phe Gly Ile Cys Lys Arg Gln Ala Gln 
    690                 695                 700                 


Ala Tyr Arg Gly Gln Arg Val Pro Pro Lys Asn Ser Thr Asp Ile Gln 
705                 710                 715                 720 


Val Gln Lys Val Thr His Glu Met Arg Gln Gly Leu His Asn Met Glu 
                725                 730                 735     


Asp Val Tyr Glu Leu Ile Glu Asn Ser His Leu Thr Pro Lys Lys Gln 
            740                 745                 750         


Gly Gln Ile Ser Glu Glu Tyr Met Gln Thr Val Leu 
        755                 760                 


<210> 16
<211> 2871
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
gggagacgcg uguuaaauaa caaaucucaa cacaacauau acaaaacaaa cgaaucucaa       60

gcaaucaagc auucuacuuc uauugcagca auuuaaauca uuucuuuuaa agcaaaagca      120

auuuucugaa aauuuucacc auuuacgaac gauagccgcc accaugaggc cugccgaccu      180

gcugcagcug gugcugcugc uggaccugcc uagagaucug ggcggcaugg gcuguagcag      240

cccuccaugc gagugccacc aggaagagga cuucagagug accugcaagg acauccagag      300

aauccccagc cugcccccca gcacccagac ccugaagcug aucgagacac accugagaac      360

caucccuagc cacgccuuca gcaaccugcc caacaucagc agaaucuacg uguccaucga      420

cgugacccug cagcagcugg aaagccacag cuucuacaac cugagcaaag ugacccacau      480

cgagaucaga aacacccgga accugaccua caucgacccc gacgcccuga aagagcugcc      540

ccugcugaag uuccugggca ucuucaacac cggccugaag auguuccccg accugaccaa      600

gguguacucu accgacaucu ucuucauccu ggaaaucacc gacaaccccu acaugaccag      660

cauccccgug aacgccuucc agggccugug caacgagaca cugacacuga agcuguacaa      720

caacggcuuc accagcgugc agggcuacgc cuucaacggc acaaagcugg acgccgugua      780

ccugaacaag aacaaguacc ugaccgugau cgacaaggac gccuucggcg gcguguacuc      840

uggaccuucu cugcuggacg ugucccagac cagcgugaca gcccugccua gcaagggccu      900

ggaacaccug aaagaacuga ucgcccgcaa caccuggacu cugaagaagc ugccucugag      960

ccugagcuuc cugcaccuga ccagagccga ccugagcuac ccaagccacu gcugcgccuu     1020

caagaaccag aagaagaucc ggggaauccu ggaaucccug auguguaacg agagcagcau     1080

gcagagccug agacagagaa agucugugaa cgcucugaac agcccccugc accaggaaua     1140

cgaggaaaac cugggcgaca gcaucguggg cuacaaagag aaguccaagu uccaggacac     1200

ccacaacaac gcccacuacu acguguucuu cgaggaacag gaagaugaga ucaucggcuu     1260

cggccaggaa cugaagaacc cucaggaaga gacacugcag gccuucgaca gccacuacga     1320

cuacaccauc ugcggcgaca gcgaggacau ggugugcacc ccuaagagcg acgaguucaa     1380

ccccugcgag gauauuaugg gguacaaguu ccugaggauc gucguguggu ucgugucccu     1440

gcuggcucug cugggcaacg uguucgugcu gcugauccug cugaccuccc acuacaagcu     1500

gaacgugccc agauuccuga ugugcaaccu ggccuucgcc gacuucugca ugggcaugua     1560

ccugcugcug auugccagcg uggaccugua cacccacagc gaguacuaca accacgccau     1620

cgacuggcag accggcccug gcuguaacac cgccggcuuu uucaccgugu ucgccagcga     1680

gcugagcgug uacacccuga cagugaucac ccuggaaagg ugguacgcca ucaccuucgc     1740

caugagacug gacagaaaga ucagacugag acacgccugc gccaucaugg ugggaggcug     1800

ggugugcugu uuccugcugg cccugcugcc ccucgugggc aucagcucuu acgccaaggu     1860

guccaucugc cugcccaugg acaccgagac accucuggcc cuggccuaca uuguguuugu     1920

gcugacccug aacaucgugg ccuucgugau cgugugcugc uguuacguga agaucuacau     1980

caccgugcgg aacccccagu acaaccccgg cgacaaggau accaagaucg ccaagagaau     2040

ggccgugcug aucuucaccg acuucaucug cauggccccc aucagcuucu augcccugag     2100

cgccauucug aacaagccuc ugaucaccgu guccaacagc aaaauccugc uggugcuguu     2160

cuacccccug aacagcugcg ccaaccccuu ccuguacgcu aucuucacca aggccuucca     2220

gagggacgug uucauccugc ugucuaaguu cggcaucugc aagagacagg cccaggccua     2280

ccggggccag agagugccuc cuaagaacuc cacagacauc caggugcaga aagugacaca     2340

cgacaugaga cagggccugc acaacaugga agauguguac gagcugauug agaacagcca     2400

ccugaccccc aagaaacagg gacagaucag cgaagaguac augcagaccg ugcugugaua     2460

acggaccggc gauagaugaa gcucgcuuuc uugcugucca auuucuauua aagguuccuu     2520

uguucccuaa guccaacuac uaaacugggg gauauuauga agggccuuga gcaucuggau     2580

ucugccuaau aaaaaacauu uauuuucauu gcagcucgcu uucuugcugu ccaauuucua     2640

uuaaagguuc cuuuguuccc uaaguccaac uacuaaacug ggggauauua ugaagggccu     2700

ugagcaucug gauucugccu aauaaaaaac auuuauuuuc auugcggccg caaaaaaaaa     2760

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2820

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a              2871


<210> 17
<211> 3877
<212> RNA
<213> Homo sapiens

<400> 17
ggaaagccga cuugcaaaac cacagauaau guucagccca gcacaguagg ggucaauuug       60

guccacuugc ucagugacaa aaagaaaaaa aaagugggcu gucacuaaag auuuugacuc      120

acaagagagg ggcuggucug gaggugggag gagggaguga cgagucaagg aggagacagg      180

gacgcaggag ggugcaagga agugucuuaa cugagacggg gguaaggcaa gagagggugg      240

aggaaauucu gcaggagaca ggcuuccucc agggucugga gaacccagag gcagcuccuc      300

cugagugcug ggaaggacuc ugggcaucuu cagcccuucu uacucucuga ggcucaagcc      360

agaaauucag gcugcuugca gaguggguga cagagccacg gagcuggugu cccugggacc      420

cucugcccgu cuucucucca cuccccagca uggaggaagg uggugauuuu gacaacuacu      480

auggggcaga caaccagucu gagugugagu acacagacug gaaauccucg ggggcccuca      540

ucccugccau cuacauguug gucuuccucc ugggcaccac gggcaacggu cuggugcucu      600

ggaccguguu ucggagcagc cgggagaaga ggcgcucagc ugauaucuuc auugcuagcc      660

uggcgguggc ugaccugacc uucgugguga cgcugccccu gugggcuacc uacacguacc      720

gggacuauga cuggcccuuu gggaccuucu ucugcaagcu cagcagcuac cucaucuucg      780

ucaacaugua cgccagcguc uucugccuca ccggccucag cuucgaccgc uaccuggcca      840

ucgugaggcc aguggccaau gcucggcuga ggcugcgggu cagcggggcc guggccacgg      900

caguucuuug ggugcuggcc gcccuccugg ccaugccugu caugguguua cgcaccaccg      960

gggacuugga gaacaccacu aaggugcagu gcuacaugga cuacuccaug guggccacug     1020

ugagcucaga gugggccugg gaggugggcc uuggggucuc guccaccacc gugggcuuug     1080

uggugcccuu caccaucaug cugaccuguu acuucuucau cgcccaaacc aucgcuggcc     1140

acuuccgcaa ggaacgcauc gagggccugc ggaagcggcg ccggcugcuc agcaucaucg     1200

uggugcuggu ggugaccuuu gcccugugcu ggaugcccua ccaccuggug aagacgcugu     1260

acaugcuggg cagccugcug cacuggcccu gugacuuuga ccucuuccuc augaacaucu     1320

uccccuacug caccugcauc agcuacguca acagcugccu caaccccuuc cucuaugccu     1380

uuuucgaccc ccgcuuccgc caggccugca ccuccaugcu cugcuguggc cagagcaggu     1440

gcgcaggcac cucccacagc agcagugggg agaagucagc cagcuacucu ucggggcaca     1500

gccaggggcc cggccccaac augggcaagg guggagaaca gaugcacgag aaauccaucc     1560

ccuacagcca ggagacccuu gugguugacu agggcuggga gcagagagaa gccuggcgcc     1620

cucggcccuc cccggccuuu gcccuugcuu ucugaaaauc agguagugug gcuacuccuu     1680

guccuaugca cauccuuuaa cuguccccug auucugcccc gcccuguccu ccucuacugc     1740

uuuauucuuu cucagagguu ugugguuuag gggaaagaga cugggcucua cagaccugac     1800

ccugcacaag ccauuuaauc ucacucagcc ucaguuucuc cauugguaug aaauggggga     1860

aagucauauu gauccuaaaa uguugaagcc ugagucugga cgcaguaaaa gcuuguuucc     1920

cucugcugcu uucuuagauc ugcaaucguc uuuccucccu ucuuuccuug uaguuuuucc     1980

cccaccacuc ucugcagcug ccgcuccuua ucccugccuu cuggcaccaa uccccuccua     2040

cagcucgucc cccucccucc auccauccuu cuccccuguc uacuuucuug uucugaaggg     2100

cuacuaaggg uuaaggaucc caaagcuugc agagacugac ccuguuuaag cuuucuaucc     2160

uguuuucuga gugugaggca gggaaugggc uggggccggg ggugggcugu gugucagcag     2220

auaauuagug cuccagcccu uagaucuggg agcuccagag cuugcccuaa aauuggauca     2280

cuucccuguc auuuugggca uuggggcuag ugugauuccu gcaguucccc cauggcacca     2340

ugacacugac uagauaugcu uucuccaaau uguccgcaga cccuuucauc cuuccucuau     2400

uuucuaugag aauuggaagg cagcagggcu gaugaaugga uguacuccuu gguuucauua     2460

ugugaguggg gaguugggaa gggcaacuag agagagagga uggaggggug ucugcauuua     2520

guccagacac ugcuuggcuc gcuccccgag uccuccuguu ucugacuucc ugcauaacug     2580

ugagcugaag gguuuccuca ucuccccauc uuaccccauc auacugauuu cuuucuuggg     2640

cacuggugcu acuuggugcc aagaaucaug uuguuuggga uggagaugcc ugccucuugu     2700

cugugugugu uguacuuaua ugucuauaug gaugagccug gcaugaacag cagugugccu     2760

gggucauuug gacaaaccuc cucccacccc ccaauccacu gcaacucugc uguucacaca     2820

uuacccuugg cagggggugg uggggggcag ggacacacug aggcaaugaa aaauguagaa     2880

uaaaaaugag uccacccccu acuggauuug ggggcuccaa cggcuggucc gugcuuuagg     2940

agcgaaguua auguuugcac caggcuuccu guagggagau cccuccccaa agcagcuggc     3000

gccaaggcuu gggggcgucc uacugagcug gguuccugcu ccuucuuggg cuccaugaag     3060

gaaguaagag gcuaguugag agccucccuu ggccccuuuc cggugccucc ccgccuggcu     3120

ucaaauuuau gagcauugcc cucaucgucc uuucuuguuc cagggucagu ggcccucuuc     3180

cuaaggaggc cuccugcuug ccaugggcca aaaggcacgg gguggguuuu uucucucccu     3240

acccucagga uuggaccucu uggcuucugc uggauugggg aucugggaau agggacugga     3300

gcaagugugc agauagcaug augucuacac ugccagagag accgugagga ugaaauuaau     3360

aguggggccu uugugagcua gaggcuggga gugucuauuc cggguuuugu ucuuggagga     3420

cuaugaaagu gaaggacaag acaugagcga uggagauaag aaaagcccag cuugauguga     3480

auggacaucu ugacccuccc uggaaugacg ccagcucugg gggcagaggg aggaggagag     3540

gggaaggggc uccucacagc cuagucuccc caucuuaaga uagcaucuuu cacagaguca     3600

ccuccucugc ccagagcugu ccucaaagca uccagugaac acuggaagag gcuucuagaa     3660

gggaagaaau ugucccucug aggccgccgu gggugaccug cagagacuuc cugccuggaa     3720

cucaucugug aacugggaca gaagcagagg aggcugccug cugugauacc cccuuaccuc     3780

ccccagugcc uucuucagaa uaucugcacu gucuucugau ccuguuaguc acugugguuc     3840

aucaaauaaa acuguuugug caacuguugu guccaaa                              3877


<210> 18
<211> 380
<212> PRT
<213> Homo sapiens

<400> 18
Met Glu Glu Gly Gly Asp Phe Asp Asn Tyr Tyr Gly Ala Asp Asn Gln 
1               5                   10                  15      


Ser Glu Cys Glu Tyr Thr Asp Trp Lys Ser Ser Gly Ala Leu Ile Pro 
            20                  25                  30          


Ala Ile Tyr Met Leu Val Phe Leu Leu Gly Thr Thr Gly Asn Gly Leu 
        35                  40                  45              


Val Leu Trp Thr Val Phe Arg Ser Ser Arg Glu Lys Arg Arg Ser Ala 
    50                  55                  60                  


Asp Ile Phe Ile Ala Ser Leu Ala Val Ala Asp Leu Thr Phe Val Val 
65                  70                  75                  80  


Thr Leu Pro Leu Trp Ala Thr Tyr Thr Tyr Arg Asp Tyr Asp Trp Pro 
                85                  90                  95      


Phe Gly Thr Phe Phe Cys Lys Leu Ser Ser Tyr Leu Ile Phe Val Asn 
            100                 105                 110         


Met Tyr Ala Ser Val Phe Cys Leu Thr Gly Leu Ser Phe Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Arg Pro Val Ala Asn Ala Arg Leu Arg Leu Arg Val 
    130                 135                 140                 


Ser Gly Ala Val Ala Thr Ala Val Leu Trp Val Leu Ala Ala Leu Leu 
145                 150                 155                 160 


Ala Met Pro Val Met Val Leu Arg Thr Thr Gly Asp Leu Glu Asn Thr 
                165                 170                 175     


Thr Lys Val Gln Cys Tyr Met Asp Tyr Ser Met Val Ala Thr Val Ser 
            180                 185                 190         


Ser Glu Trp Ala Trp Glu Val Gly Leu Gly Val Ser Ser Thr Thr Val 
        195                 200                 205             


Gly Phe Val Val Pro Phe Thr Ile Met Leu Thr Cys Tyr Phe Phe Ile 
    210                 215                 220                 


Ala Gln Thr Ile Ala Gly His Phe Arg Lys Glu Arg Ile Glu Gly Leu 
225                 230                 235                 240 


Arg Lys Arg Arg Arg Leu Leu Ser Ile Ile Val Val Leu Val Val Thr 
                245                 250                 255     


Phe Ala Leu Cys Trp Met Pro Tyr His Leu Val Lys Thr Leu Tyr Met 
            260                 265                 270         


Leu Gly Ser Leu Leu His Trp Pro Cys Asp Phe Asp Leu Phe Leu Met 
        275                 280                 285             


Asn Ile Phe Pro Tyr Cys Thr Cys Ile Ser Tyr Val Asn Ser Cys Leu 
    290                 295                 300                 


Asn Pro Phe Leu Tyr Ala Phe Phe Asp Pro Arg Phe Arg Gln Ala Cys 
305                 310                 315                 320 


Thr Ser Met Leu Cys Cys Gly Gln Ser Arg Cys Ala Gly Thr Ser His 
                325                 330                 335     


Ser Ser Ser Gly Glu Lys Ser Ala Ser Tyr Ser Ser Gly His Ser Gln 
            340                 345                 350         


Gly Pro Gly Pro Asn Met Gly Lys Gly Gly Glu Gln Met His Glu Lys 
        355                 360                 365             


Ser Ile Pro Tyr Ser Gln Glu Thr Leu Val Val Asp 
    370                 375                 380 


<210> 19
<211> 1716
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
gggagacgcg uguuaaauaa caaaucucaa cacaacauau acaaaacaaa cgaaucucaa       60

gcaaucaagc auucuacuuc uauugcagca auuuaaauca uuucuuuuaa agcaaaagca      120

auuuucugaa aauuuucacc auuuacgaac gauagccgcc accauggaag agggcggcga      180

cuucgacaac uacuacggcg ccgacaacca gagcgagugc gaguacaccg acuggaaguc      240

cucuggcgcc cugauccccg cuaucuacau gcugguguuu cugcugggca ccaccggcaa      300

cggacuggug cuguggaccg uguucagaag cagcagagag aagcggcgga gcgccgacau      360

cuuuaucgcc agccuggccg uggccgaccu gaccuuuguc gugacacugc cucugugggc      420

caccuacacc uaccgggacu acgacuggcc cuucggcaca uuuuucugca agcugagcag      480

cuaccugauc uucgugaaua uguacgccag cguguucugc cugaccggcc ugagcuucga      540

cagauaccug gccaucgugc ggcccguggc caacgcuaga cugcggcuga gagugucugg      600

cgccguggcu acagcugugc ugugggugcu ggcugcccug cuggcuaugc cugugauggu      660

gcugagaacc accggcgacc uggaaaacac caccaaggug cagugcuaca uggacuacag      720

caugguggcc acagugucca gcgagugggc cugggaagug ggacugggag ugucuagcac      780

caccgugggc uucguggugc ccuucaccau uaugcugacc ugcuacuucu ucauugccca      840

gacaaucgcc ggccacuucc ggaaagagcg gaucgagggc cugcggaaga gaaggcggcu      900

gcugagcauc aucguggugc uggucgugac cuucgcccug ugcuggaugc cuuaccaccu      960

cgugaaaacc cuguauaugc ugggcagccu gcugcacugg cccugcgauu ucgaccuguu     1020

ccugaugaac aucuuccccu acugcaccug uaucagcuac gugaacagcu gccugaaccc     1080

cuuccuguac gccuucuucg acccccgguu cagacaggcc ugcaccucca ugcugugcug     1140

cggccagucu agaugcgccg gcacaagcca cagcagcagc ggcgagaagu cugccagcua     1200

cagcucuggc cacagccagg gcccaggccc caauauggga aagggcggag agcagaugca     1260

cgagaagucc aucccuuaca gccaggaaac ccugguggug gacugacgga ccggcgauag     1320

augaagcucg cuuucuugcu guccaauuuc uauuaaaggu uccuuuguuc ccuaagucca     1380

acuacuaaac ugggggauau uaugaagggc cuugagcauc uggauucugc cuaauaaaaa     1440

acauuuauuu ucauugcagc ucgcuuucuu gcuguccaau uucuauuaaa gguuccuuug     1500

uucccuaagu ccaacuacua aacuggggga uauuaugaag ggccuugagc aucuggauuc     1560

ugccuaauaa aaaacauuua uuuucauugc ggccgcaaaa aaaaaaaaaa aaaaaaaaaa     1620

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                               1716


<210> 20
<211> 3085
<212> RNA
<213> Homo sapiens

<400> 20
gagcagccaa aaggcccgcg gagucgcgcu gggccgcccc ggcgcagcug aaccgggggc       60

cgcgccugcc aggccgacgg gucuggccca gccuggcgcc aagggguucg ugcgcugugg      120

agacgcggag ggucgaggcg gcgcggccug agugaaaccc aauggaaaaa gcaugacauu      180

uagaaguaga agacuuagcu ucaaaucccu acuccuucac uuacuaauuu ugugauuugg      240

aaauauccgc gcaagauguu gacguugcag acuuggguag ugcaagccuu guuuauuuuc      300

cucaccacug aaucuacagg ugaacuucua gauccaugug guuauaucag uccugaaucu      360

ccaguuguac aacuucauuc uaauuucacu gcaguuugug ugcuaaagga aaaauguaug      420

gauuauuuuc auguaaaugc uaauuacauu gucuggaaaa caaaccauuu uacuauuccu      480

aaggagcaau auacuaucau aaacagaaca gcauccagug ucaccuuuac agauauagcu      540

ucauuaaaua uucagcucac uugcaacauu cuuacauucg gacagcuuga acagaauguu      600

uauggaauca caauaauuuc aggcuugccu ccagaaaaac cuaaaaauuu gaguugcauu      660

gugaacgagg ggaagaaaau gaggugugag ugggauggug gaagggaaac acacuuggag      720

acaaacuuca cuuuaaaauc ugaaugggca acacacaagu uugcugauug caaagcaaaa      780

cgugacaccc ccaccucaug cacuguugau uauucuacug uguauuuugu caacauugaa      840

gucuggguag aagcagagaa ugcccuuggg aagguuacau cagaucauau caauuuugau      900

ccuguauaua aagugaagcc caauccgcca cauaauuuau cagugaucaa cucagaggaa      960

cugucuagua ucuuaaaauu gacauggacc aacccaagua uuaagagugu uauaauacua     1020

aaauauaaca uucaauauag gaccaaagau gccucaacuu ggagccagau uccuccugaa     1080

gacacagcau ccacccgauc uucauucacu guccaagacc uuaaaccuuu uacagaauau     1140

guguuuagga uucgcuguau gaaggaagau gguaagggau acuggaguga cuggagugaa     1200

gaagcaagug ggaucaccua ugaagauaga ccaucuaaag caccaaguuu cugguauaaa     1260

auagauccau cccauacuca aggcuacaga acuguacaac ucguguggaa gacauugccu     1320

ccuuuugaag ccaauggaaa aaucuuggau uaugaaguga cucucacaag auggaaauca     1380

cauuuacaaa auuacacagu uaaugccaca aaacugacag uaaaucucac aaaugaucgc     1440

uaucuagcaa cccuaacagu aagaaaucuu guuggcaaau cagaugcagc uguuuuaacu     1500

aucccugccu gugacuuuca agcuacucac ccuguaaugg aucuuaaagc auuccccaaa     1560

gauaacaugc uuugggugga auggacuacu ccaagggaau cuguaaagaa auauauacuu     1620

gaguggugug uguuaucaga uaaagcaccc uguaucacag acuggcaaca agaagauggu     1680

accgugcauc gcaccuauuu aagagggaac uuagcagaga gcaaaugcua uuugauaaca     1740

guuacuccag uauaugcuga uggaccagga agcccugaau ccauaaaggc auaccuuaaa     1800

caagcuccac cuuccaaagg accuacuguu cggacaaaaa aaguagggaa aaacgaagcu     1860

gucuuagagu gggaccaacu uccuguugau guucagaaug gauuuaucag aaauuauacu     1920

auauuuuaua gaaccaucau uggaaaugaa acugcuguga auguggauuc uucccacaca     1980

gaauauacau uguccucuuu gacuagugac acauuguaca ugguacgaau ggcagcauac     2040

acagaugaag gugggaagga ugguccagaa uucacuuuua cuaccccaaa guuugcucaa     2100

ggagaaauug aagccauagu cgugccuguu ugcuuagcau uccuauugac aacucuucug     2160

ggagugcugu ucugcuuuaa uaagcgagac cuaauuaaaa aacacaucug gccuaauguu     2220

ccagauccuu caaagaguca uauugcccag uggucaccuc acacuccucc aaggcacaau     2280

uuuaauucaa aagaucaaau guauucagau ggcaauuuca cugauguaag uguuguggaa     2340

auagaagcaa augacaaaaa gccuuuucca gaagaucuga aaucauugga ccuguucaaa     2400

aaggaaaaaa uuaauacuga aggacacagc agugguauug gggggucuuc augcauguca     2460

ucuucuaggc caagcauuuc uagcagugau gaaaaugaau cuucacaaaa cacuucgagc     2520

acuguccagu auucuaccgu gguacacagu ggcuacagac accaaguucc gucaguccaa     2580

gucuucucaa gauccgaguc uacccagccc uuguuagauu cagaggagcg gccagaagau     2640

cuacaauuag uagaucaugu agauggcggu gaugguauuu ugcccaggca acaguacuuc     2700

aaacagaacu gcagucagca ugaauccagu ccagauauuu cacauuuuga aaggucaaag     2760

caaguuucau cagucaauga ggaagauuuu guuagacuua aacagcagau uucagaucau     2820

auuucacaau ccuguggauc ugggcaaaug aaaauguuuc aggaaguuuc ugcagcagau     2880

gcuuuugguc cagguacuga gggacaagua gaaagauuug aaacaguugg cauggaggcu     2940

gcgacugaug aaggcaugcc uaaaaguuac uuaccacaga cuguacggca aggcggcuac     3000

augccucagu gaaggacuag uaguuccugc uacaacuuca gcaguaccua uaaaguaaag     3060

cuaaaaugau uuuaucugug aauuc                                           3085


<210> 21
<211> 918
<212> PRT
<213> Homo sapiens

<400> 21
Met Leu Thr Leu Gln Thr Trp Leu Val Gln Ala Leu Phe Ile Phe Leu 
1               5                   10                  15      


Thr Thr Glu Ser Thr Gly Glu Leu Leu Asp Pro Cys Gly Tyr Ile Ser 
            20                  25                  30          


Pro Glu Ser Pro Val Val Gln Leu His Ser Asn Phe Thr Ala Val Cys 
        35                  40                  45              


Val Leu Lys Glu Lys Cys Met Asp Tyr Phe His Val Asn Ala Asn Tyr 
    50                  55                  60                  


Ile Val Trp Lys Thr Asn His Phe Thr Ile Pro Lys Glu Gln Tyr Thr 
65                  70                  75                  80  


Ile Ile Asn Arg Thr Ala Ser Ser Val Thr Phe Thr Asp Ile Ala Ser 
                85                  90                  95      


Leu Asn Ile Gln Leu Thr Cys Asn Ile Leu Thr Phe Gly Gln Leu Glu 
            100                 105                 110         


Gln Asn Val Tyr Gly Ile Thr Ile Ile Ser Gly Leu Pro Pro Glu Lys 
        115                 120                 125             


Pro Lys Asn Leu Ser Cys Ile Val Asn Glu Gly Lys Lys Met Arg Cys 
    130                 135                 140                 


Glu Trp Asp Arg Gly Arg Glu Thr His Leu Glu Thr Asn Phe Thr Leu 
145                 150                 155                 160 


Lys Ser Glu Trp Ala Thr His Lys Phe Ala Asp Cys Lys Ala Lys Arg 
                165                 170                 175     


Asp Thr Pro Thr Ser Cys Thr Val Asp Tyr Ser Thr Val Tyr Phe Val 
            180                 185                 190         


Asn Ile Glu Val Trp Val Glu Ala Glu Asn Ala Leu Gly Lys Val Thr 
        195                 200                 205             


Ser Asp His Ile Asn Phe Asp Pro Val Tyr Lys Val Lys Pro Asn Pro 
    210                 215                 220                 


Pro His Asn Leu Ser Val Ile Asn Ser Glu Glu Leu Ser Ser Ile Leu 
225                 230                 235                 240 


Lys Leu Thr Trp Thr Asn Pro Ser Ile Lys Ser Val Ile Ile Leu Lys 
                245                 250                 255     


Tyr Asn Ile Gln Tyr Arg Thr Lys Asp Ala Ser Thr Trp Ser Gln Ile 
            260                 265                 270         


Pro Pro Glu Asp Thr Ala Ser Thr Arg Ser Ser Phe Thr Val Gln Asp 
        275                 280                 285             


Leu Lys Pro Phe Thr Glu Tyr Val Phe Arg Ile Arg Cys Met Lys Glu 
    290                 295                 300                 


Asp Gly Lys Gly Tyr Trp Ser Asp Trp Ser Glu Glu Ala Ser Gly Ile 
305                 310                 315                 320 


Thr Tyr Glu Asp Arg Pro Ser Lys Ala Pro Ser Phe Trp Tyr Lys Ile 
                325                 330                 335     


Asp Pro Ser His Thr Gln Gly Tyr Arg Thr Val Gln Leu Val Trp Lys 
            340                 345                 350         


Thr Leu Pro Pro Phe Glu Ala Asn Gly Lys Ile Leu Asp Tyr Glu Val 
        355                 360                 365             


Thr Leu Thr Arg Trp Lys Ser His Leu Gln Asn Tyr Thr Val Asn Ala 
    370                 375                 380                 


Thr Lys Leu Thr Val Asn Leu Thr Asn Asp Arg Tyr Val Ala Thr Leu 
385                 390                 395                 400 


Thr Val Arg Asn Leu Val Gly Lys Ser Asp Ala Ala Val Leu Thr Ile 
                405                 410                 415     


Pro Ala Cys Asp Phe Gln Ala Thr His Pro Val Met Asp Leu Lys Ala 
            420                 425                 430         


Phe Pro Lys Asp Asn Met Leu Trp Val Glu Trp Thr Thr Pro Arg Glu 
        435                 440                 445             


Ser Val Lys Lys Tyr Ile Leu Glu Trp Cys Val Leu Ser Asp Lys Ala 
    450                 455                 460                 


Pro Cys Ile Thr Asp Trp Gln Gln Glu Asp Gly Thr Val His Arg Thr 
465                 470                 475                 480 


Tyr Leu Arg Gly Asn Leu Ala Glu Ser Lys Cys Tyr Leu Ile Thr Val 
                485                 490                 495     


Thr Pro Val Tyr Ala Asp Gly Pro Gly Ser Pro Glu Ser Ile Lys Ala 
            500                 505                 510         


Tyr Leu Lys Gln Ala Pro Pro Ser Lys Gly Pro Thr Val Arg Thr Lys 
        515                 520                 525             


Lys Val Gly Lys Asn Glu Ala Val Leu Glu Trp Asp Gln Leu Pro Val 
    530                 535                 540                 


Asp Val Gln Asn Gly Phe Ile Arg Asn Tyr Thr Ile Phe Tyr Arg Thr 
545                 550                 555                 560 


Ile Ile Gly Asn Glu Thr Ala Val Asn Val Asp Ser Ser His Thr Glu 
                565                 570                 575     


Tyr Thr Leu Ser Ser Leu Thr Ser Asp Thr Leu Tyr Met Val Arg Met 
            580                 585                 590         


Ala Ala Tyr Thr Asp Glu Gly Gly Lys Asp Gly Pro Glu Phe Thr Phe 
        595                 600                 605             


Thr Thr Pro Lys Phe Ala Gln Gly Glu Ile Glu Ala Ile Val Val Pro 
    610                 615                 620                 


Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu Gly Val Leu Phe Cys 
625                 630                 635                 640 


Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro 
                645                 650                 655     


Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro 
            660                 665                 670         


Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe 
        675                 680                 685             


Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe 
    690                 695                 700                 


Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn 
705                 710                 715                 720 


Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser 
                725                 730                 735     


Ser Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn 
            740                 745                 750         


Thr Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg 
        755                 760                 765             


His Gln Val Pro Ser Val Gln Val Phe Ser Arg Ser Glu Ser Thr Gln 
    770                 775                 780                 


Pro Leu Leu Asp Ser Glu Glu Arg Pro Glu Asp Leu Gln Leu Val Asp 
785                 790                 795                 800 


His Val Asp Gly Gly Asp Gly Ile Leu Pro Arg Gln Gln Tyr Phe Lys 
                805                 810                 815     


Gln Asn Cys Ser Gln His Glu Ser Ser Pro Asp Ile Ser His Phe Glu 
            820                 825                 830         


Arg Ser Lys Gln Val Ser Ser Val Asn Glu Glu Asp Phe Val Arg Leu 
        835                 840                 845             


Lys Gln Gln Ile Ser Asp His Ile Ser Gln Ser Cys Gly Ser Gly Gln 
    850                 855                 860                 


Met Lys Met Phe Gln Glu Val Ser Ala Ala Asp Ala Phe Gly Pro Gly 
865                 870                 875                 880 


Thr Glu Gly Gln Val Glu Arg Phe Glu Thr Val Gly Met Glu Ala Ala 
                885                 890                 895     


Thr Asp Glu Gly Met Pro Lys Ser Tyr Leu Pro Gln Thr Val Arg Gln 
            900                 905                 910         


Gly Gly Tyr Met Pro Gln 
        915             


<210> 22
<211> 3329
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 22
gggagacgcg uguuaaauaa caaaucucaa cacaacauau acaaaacaaa cgaaucucaa       60

gcaaucaagc auucuacuuc uauugcagca auuuaaauca uuucuuuuaa agcaaaagca      120

auuuucugaa aauuuucacc auuuacgaac gauagccgcc accgcaucgu gaacgagggc      180

aagaaaaugc ugacccugca gaccuggcug gugcaggccc uguucaucuu ccugaccacc      240

gagagcaccg gcgagcugcu ggacccuugu ggcuacauca gccccgagag cccuguggug      300

cagcugcaua gcaacuucac cgccgugugc gugcugaaag aaaagugcau ggacuacuuc      360

cacgugaacg ccaacuacau cguguggaaa acaaaccacu ucaccauccc caaagagcag      420

uacaccauca ucaacagaac cgccagcagc gugaccuuca ccgauaucgc cagccugaac      480

auccagcuga ccugcaacau ccugaccuuc ggccagcugg aacagaacgu guacggcauc      540

acaaucauca gcggccugcc ccccgagaag cccaagaacc ugagcugcau cgugaacgag      600

ggcaagaaaa ugagaugcga gugggacggc ggcagagaga cacaccugga aacaaacuuc      660

acccugaagu ccgagugggc cacccacaag uucgccgacu gcaaggccaa gagggacacc      720

cccaccagcu guaccgugga cuacagcacc guguacuucg ugaacaucga agugugggug      780

gaagccgaga acgcccuggg caaagugacc agcgaccaca ucaacuucga cccuguguac      840

aaagugaagc ccaacccccc ccacaaccug agcgugauca acagcgagga acugagcagc      900

auccugaagc ugacauggac caaccccagc aucaaguccg ugaucauucu gaaguacaac      960

auccaguacc ggaccaagga cgccagcacc uggucccaga ucccuccaga ggacaccgcc     1020

uccaccagau ccagcuucac agugcaggac cugaagccuu ucaccgagua cguguucagg     1080

auucggugca ugaaggaaga uggcaagggc uacuggagcg auuggagcga ggaagccagc     1140

ggcaucaccu acgaggacag acccucuaag gcccccagcu ucugguacaa gaucgacccc     1200

agccacaccc agggcuacag aaccgugcag cucgugugga aaacccugcc cccauucgag     1260

gccaacggca agauccugga cuacgaagug acccugacca gauggaaguc ccaucugcag     1320

aacuacaccg ugaacgcuac caagcugacc gugaaccuga caaacgacag auaccuggcc     1380

acccugaccg ugcggaaccu cgugggcaag ucugaugccg ccgugcugac cauccccgca     1440

ugcgauuuuc aagccaccca ccccgugaug gaucugaagg cuuuccccaa ggacaacaug     1500

cugugggugg aauggaccac ccccagagaa agcgugaaaa aguacauccu ggaauggugu     1560

gugcugagcg acaaggcccc cugcaucacc gauuggcagc aggaagaugg aaccgugcac     1620

agaaccuacc ugagaggcaa ccuggccgag agcaagugcu accugaucac cgugaccccc     1680

guguacgcug acggcccugg aagcccugag agcaucaagg ccuaccugaa gcaggccccu     1740

cccagcaagg gaccuacagu gcggaccaag aaagugggca agaacgaggc cgugcuggaa     1800

ugggaccagc ugccugugga ugugcagaac ggcuucauca gaaacuacac caucuucuac     1860

aggaccauca ucggcaacga gacagccgug aacguggaca gcagccacac agaguacacc     1920

cugagcagcc ugaccuccga cacccuguau auggugcgaa uggccgccua caccgacgag     1980

ggcggaaagg auggccccga guucaccuuc accacaccua aguucgcuca gggcgagauc     2040

gaggccaucg uggugccugu gugucuggcu uuccugcuga ccacccugcu gggcgugcug     2100

uucugcuuca acaagcggga ccugaucaag aagcacaucu ggcccaacgu gcccgacccu     2160

agcaagagcc auaucgccca gugguccccc cacacccccc cuagacacaa cuucaacagc     2220

aaggaccaga uguacagcga cggcaacuuu acagacgugu ccguggugga aaucgaggcu     2280

aacgauaaga agcccuuccc agaagaucug aagucccugg aucuguucaa gaaagagaag     2340

aucaacacag agggccacag cuccggcauc ggcggcagcu cuuguaugag cagcagcaga     2400

ccuagcauca gcagcagcga cgagaacgag agcagccaga acaccucuag caccgugcag     2460

uacuccaccg uggugcacag cggcuacaga caccaggugc caagcgugca gguguucagc     2520

agaagcgagu ccacccagcc ccugcuggac agcgaagaga ggccugagga ucugcagcug     2580

guggaccaug uggacggcgg agauggcauc cugcccagac agcaguacuu caagcagaac     2640

ugcucccagc acgaguccag ccccgacauc agccacuucg agagaagcaa acaggugucc     2700

agcgugaacg aagaggacuu cgugcggcug aagcagcaga ucagcgauca caucucccag     2760

agcugcggca gcggccagau gaagauguuc caggaagugu ccgccgcuga cgccuucgga     2820

ccuggaacug agggccaggu ggaaagauuc gagacagugg gcauggaagc cgccacagac     2880

gagggcaugc cuaagagcua ccugccccag acugugcggc agggcggcua caugccucag     2940

ugaagcucgc uuucuugcug uccaauuucu auuaaagguu ccuuuguucc cuaaguccaa     3000

cuacuaaacu gggggauauu augaagggcc uugagcaucu ggauucugcc uaauaaaaaa     3060

cauuuauuuu cauugcagcu cgcuuucuug cuguccaauu ucuauuaaag guuccuuugu     3120

ucccuaaguc caacuacuaa acugggggau auuaugaagg gccuugagca ucuggauucu     3180

gccuaauaaa aaacauuuau uuucauugca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3240

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaa                                       3329


<210> 23
<211> 7
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence


<220>
<221> modified_base
<222> (2)..(3)
<223> a, g, c or u

<400> 23
annaugg                                                                  7


<210> 24
<211> 7
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence

<400> 24
accaugg                                                                  7


<210> 25
<211> 10
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence

<400> 25
gacaccaugg                                                              10


<210> 26
<211> 1017
<212> RNA
<213> Homo sapiens

<400> 26
gaguauuuga ggcucggagc caccgccccg ccggcgcccg cagcaccucc ucgccagcag       60

ccguccggag ccagccaacg agcggaaaau ggcagacaau uuuucgcucc augaugcguu      120

aucugggucu ggaaacccaa acccucaagg auggccuggc gcauggggga accagccugc      180

uggggcaggg ggcuacccag gggcuuccua uccuggggcc uaccccgggc aggcaccccc      240

aggggcuuau ccuggacagg caccuccagg cgccuacccu ggagcaccug gagcuuaucc      300

cggagcaccu gcaccuggag ucuacccagg gccacccagc ggcccugggg ccuacccauc      360

uucuggacag ccaagugcca ccggagccua cccugccacu ggccccuaug gcgccccugc      420

ugggccacug auugugccuu auaaccugcc uuugccuggg ggaguggugc cucgcaugcu      480

gauaacaauu cugggcacgg ugaagcccaa ugcaaacaga auugcuuuag auuuccaaag      540

agggaaugau guugccuucc acuuuaaccc acgcuucaau gagaacaaca ggagagucau      600

uguuugcaau acaaagcugg auaauaacug gggaagggaa gaaagacagu cgguuuuccc      660

auuugaaagu gggaaaccau ucaaaauaca aguacugguu gaaccugacc acuucaaggu      720

ugcagugaau gaugcucacu uguugcagua caaucaucgg guuaaaaaac ucaaugaaau      780

cagcaaacug ggaauuucug gugacauaga ccucaccagu gcuucauaua ccaugauaua      840

aucugaaagg ggcagauuaa aaaaaaaaaa agaaucuaaa ccuuacaugu guaaagguuu      900

cauguucacu gugagugaaa auuuuuacau ucaucaauau cccucuugua agucaucuac      960

uuaauaaaua uuacagugaa uuaccugucu caauauguca aaaaaaaaaa aaaaaaa        1017


<210> 27
<211> 250
<212> PRT
<213> Homo sapiens

<400> 27
Met Ala Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn 
1               5                   10                  15      


Pro Asn Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly 
            20                  25                  30          


Ala Gly Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln 
        35                  40                  45              


Ala Pro Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro 
    50                  55                  60                  


Gly Ala Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro 
65                  70                  75                  80  


Gly Pro Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser 
                85                  90                  95      


Ala Thr Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly 
            100                 105                 110         


Pro Leu Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro 
        115                 120                 125             


Arg Met Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg 
    130                 135                 140                 


Ile Ala Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn 
145                 150                 155                 160 


Pro Arg Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys 
                165                 170                 175     


Leu Asp Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe 
            180                 185                 190         


Glu Ser Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His 
        195                 200                 205             


Phe Lys Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg 
    210                 215                 220                 


Val Lys Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile 
225                 230                 235                 240 


Asp Leu Thr Ser Ala Ser Tyr Thr Met Ile 
                245                 250 


<210> 28
<211> 11
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence

<400> 28
aaaaaatgtc t                                                            11


<210> 29
<211> 12
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence


<220>
<221> modified_base
<222> (11)..(11)
<223> a, g, c or t

<400> 29
aaaaaaatgr na                                                           12


<210> 30
<211> 12
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence


<220>
<221> modified_base
<222> (1)..(1)
<223> a, g, c or t

<400> 30
ntaaaaatgr ct                                                           12


<210> 31
<211> 12
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence


<220>
<221> modified_base
<222> (12)..(12)
<223> a, g, c or t

<400> 31
taaaaaatga an                                                           12


<210> 32
<211> 10
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence


<220>
<221> modified_base
<222> (2)..(2)
<223> a, g, c or t

<400> 32
gncaaaatgg                                                              10


<210> 33
<211> 11
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence


<220>
<221> modified_base
<222> (1)..(3)
<223> a, g, c or t

<220>
<221> modified_base
<222> (5)..(6)
<223> a, g, c or t

<220>
<221> modified_base
<222> (10)..(10)
<223> a, g, c or t

<400> 33
nnnannatgn c                                                            11


<210> 34
<211> 9
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence

<400> 34
aacaatggc                                                                9


<210> 35
<211> 3874
<212> DNA
<213> Homo sapiens

<400> 35
gtgcgtgtgt gtaaagaagg agattaggac atttagagaa ggagggcggg gaggagagat       60

cctgagaata gaaaggagga aagaaaaaaa gaggaatgga aagagacaga gaaaggaaat      120

gggagtggaa ggagggagga ctgctttgta actgctaaga ttgcagacag aaatagcaca      180

caaccactgt gagctgtatg cgattcagaa accaagacca aattttgctc actttcatta      240

atcagttgct cagatagaag gaaatgacat ctggttctgt cttcttctac atcttaattt      300

ttggaaaata tttttctcat gggggtggac aggatgtcaa gtgctccctt ggctatttcc      360

cctgtgggaa catcacaaag tgcttgcctc agctcctgca ctgtaacggt gtggacgact      420

gcgggaatca ggccgatgag gacaactgtg gagacaacaa tggatggtct ctgcaatttg      480

acaaatattt tgccagttac tacaaaatga cttcccaata tccttttgag gcagaaacac      540

ctgaatgttt ggtcggttct gtgccagtgc aatgtctttg ccaaggtctg gagcttgact      600

gtgatgaaac caatttacga gctgttccat cggtttcttc aaatgtgact gcaatgtcac      660

ttcagtggaa cttaataaga aagcttcctc ctgattgctt caagaattat catgatcttc      720

agaagctgta cctgcaaaac aataagatta catccatctc catctatgct ttcagaggac      780

tgaatagcct tactaaactg tatctcagtc ataacagaat aaccttcctg aagccgggtg      840

tttttgaaga tcttcacaga ctagaatggc tgataattga agataatcac ctcagtcgaa      900

tttccccacc aacattttat ggactaaatt ctcttattct cttagtcctg atgaataacg      960

tcctcacccg tttacctgat aaacctctct gtcaacacat gccaagacta cattggctgg     1020

accttgaagg caaccatatc cataatttaa gaaatttgac ttttatttcc tgcagtaatt     1080

taactgtttt agtgatgagg aaaaacaaaa ttaatcactt aaatgaaaat acttttgcac     1140

ctctccagaa actggatgaa ttggatttag gaagtaataa gattgaaaat cttccaccgc     1200

ttatattcaa ggacctgaag gagctgtcac aattgaatct ttcctataat ccaatccaga     1260

aaattcaagc aaaccaattt gattatcttg tcaaactcaa gtctctcagc ctagaaggga     1320

ttgaaatttc aaatatccaa caaaggatgt ttagacctct tatgaatctc tctcacatat     1380

attttaagaa attccagtac tgtgggtatg caccacatgt tcgcagctgt aaaccaaaca     1440

ctgatggaat ttcatctcta gagaatctct tggcaagcat tattcagaga gtatttgtct     1500

gggttgtatc tgcagttacc tgctttggaa acatttttgt catttgcatg cgaccttata     1560

tcaggtctga gaacaagctg tatgccatgt caatcatttc tctctgctgt gccgactgct     1620

taatgggaat atatttattc gtgatcggag gctttgacct aaagtttcgt ggagaataca     1680

ataagcatgc gcagctgtgg atggagagta ctcattgtca gcttgtagga tctttggcca     1740

ttctgtccac agaagtatca gttttactgt taacatttct gacattggaa aaatacatct     1800

gcattgtcta tccttttaga tgtgtgagac ctggaaaatg cagaacaatt acagttctga     1860

ttctcatttg gattactggt tttatagtgg ctttcattcc attgagcaat aaggaatttt     1920

tcaaaaacta ctatggcacc aatggagtat gcttccctct tcattcagaa gatacagaaa     1980

gtattggagc ccagatttat tcagtggcaa tttttcttgg tattaatttg gccgcattta     2040

tcatcatagt tttttcctat ggaagcatgt tttatagtgt tcatcaaagt gccataacag     2100

caactgaaat acggaatcaa gttaaaaaag agatgatcct tgccaaacgt tttttcttta     2160

tagtatttac tgatgcatta tgctggatac ccatttttgt agtgaaattt ctttcactgc     2220

ttcaggtaga aataccaggt accataacct cttgggtagt gatttttatt ctgcccatta     2280

acagtgcttt gaacccaatt ctctatactc tgaccacaag accatttaaa gaaatgattc     2340

atcggttttg gtataactac agacaaagaa aatctatgga cagcaaaggt cagaaaacat     2400

atgctccatc attcatctgg gtggaaatgt ggccactgca ggagatgcca cctgagttaa     2460

tgaagccgga ccttttcaca tacccctgtg aaatgtcact gatttctcaa tcaacgagac     2520

tcaattccta ttcatgactg actctgaaat tcatttcttc gcagagaata ctgtgggggt     2580

gcttcatgag ggatttactg gtatgaaatg aataccacaa aattaattta taataatagc     2640

taagataaat attttacaag gacatgagga aaaataaaaa tgactaatgc tcttacaaag     2700

ggaagtaatt atatcaataa tgtatatata ttagtagaca ttttgcataa gaaattaaga     2760

gaaatctact tcagtaacat tcattcattt ttctaacatg catttattga gtacccacta     2820

ctatgtgcat agcattgcaa tatagtcctg gaagtagaca gtgcagaacc tttcaatctg     2880

tagatggtgt ttaatgacaa aagactatac aaagtccatc tgcagttcct agtttaaagt     2940

agagctttac ctgtcatgtg catcagcaag aatcataggc acttttaaat aaaggtttaa     3000

agttttggaa tactcagtgt atttgcatca tagaaaatgt ctgactgttt gcaaaataat     3060

attctgtttt aagaatccat cttacctctc tttaagtttc catacacttg agagccaaca     3120

caacatattt attactaaaa agatgctttg ctagaaactc aaaaacagca cttcttttgg     3180

cacttcctgc ccagttttct ctttgcttta aatgaacatc atcatatgga attggaatag     3240

gagagtatga gtacggcaga gaagtggatc agaaaaacta gaatgaggat aaacatttac     3300

attagtggaa actcctgaaa taaatccttg tattgtcagt taactgattt tcaacaagga     3360

tgccaagaca aaaaggcttt tcaacaaacc gtgctgtttt aagaacagac ctaagtggtt     3420

taattcaccc actttagatg ggtgaatgtt atggtgtgtg aaatatctca gtaaagcagt     3480

taaaaggaaa aagagctgga atgcactgat tcaggaactt aatttcagga aggaaaggtc     3540

tgtatgtaca catttcactt taagcagaaa atctttcttc aagaaatgac tttactttct     3600

ctttgcactg ccagcacgtg agatactaac tttttaacta gttgttcttc tctagtctct     3660

acgttattag aattttttgc tttcataatg tgaaaccttt aagcaggaga agaaaatgtt     3720

ttcagatagt ttcaaataca ccaaaaatgt ttgaaacaca aaaatactgg aatcaaacca     3780

taatgcactt attgaatata tagttgtata gatttgttct gaaaataaat tatctgaaat     3840

ttaactatta aaaaaaaaaa aaaaaaaaaa aaaa                                 3874


<210> 36
<211> 2883
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 36
ggaggccgga gaattgtaat acgactcact atagggagac gcgtgttaaa taacaaatct       60

caacacaaca tatacaaaac aaacgaatct caagcaatca agcattctac ttctattgca      120

gcaatttaaa tcatttcttt taaagcaaaa gcaattttct gaaaattttc accatttacg      180

aacgatagcc gccaccatga caagcggcag cgtgttcttc tacatcctga tcttcggcaa      240

gtacttcagc cacggcggag gccaggacgt gaagtgtagc ctgggctact tcccctgcgg      300

caacatcacc aagtgcctgc cccagctgct gcactgcaac ggcgtggacg attgcggcaa      360

ccaggccgac gaggacaact gcggcgacaa caatggctgg tccctgcagt tcgataagta      420

cttcgcctcc tactacaaga tgaccagcca gtaccccttc gaggccgaga cacctgagtg      480

cctcgtgggc tctgtgcctg tgcagtgtct gtgccagggc ctggaactgg actgcgacga      540

gacaaacctg agagccgtgc ccagcgtgtc cagcaacgtg acagccatga gcctgcagtg      600

gaacctgatc cggaagctgc cccccgactg cttcaagaac taccacgacc tgcagaagct      660

gtatctgcag aacaacaaga tcacctccat cagcatctac gccttccggg gcctgaacag      720

cctgaccaag ctgtacctga gccacaaccg gatcaccttt ctgaagcccg gcgtgttcga      780

ggacctgcac agactggaat ggctgatcat cgaggacaat cacctgagcc ggatcagccc      840

ccccaccttc tacggcctga actccctgat cctgctggtg ctgatgaaca acgtgctgac      900

ccggctgccc gacaagcccc tgtgtcagca catgcccaga ctgcactggc tggacctgga      960

aggcaaccac atccacaacc tgcggaacct gaccttcatc agctgcagca acctgaccgt     1020

gctcgtgatg cggaagaaca agattaacca cctgaacgag aacaccttcg cccccctgca     1080

gaaactggac gagctggatc tgggctctaa caagatcgag aacctgcccc ctctgatctt     1140

caaggacctg aaagagctga gccagctgaa cctgtcctac aaccccatcc agaagatcca     1200

ggccaaccag ttcgactacc tcgtgaagct gaagtccctg tccctggaag ggatcgagat     1260

cagcaacatc cagcagcgga tgttccggcc cctgatgaat ctgtcccaca tctacttcaa     1320

gaagttccag tactgcggct acgcccccca cgtgcggagc tgcaagccta acacagacgg     1380

catcagcagc ctggaaaacc tgctggcctc catcatccag cgggtgttcg tgtgggtggt     1440

gtccgccgtg acctgcttcg gcaatatctt cgtgatctgc atgcggccct acattcggag     1500

cgagaacaag ctgtatgcca tgagcatcat ctccctgtgc tgcgccgact gcctgatggg     1560

catctacctg ttcgtgatcg gcggcttcga cctgaagttc cggggcgagt acaacaagca     1620

cgcccagctg tggatggaaa gcacccactg ccagctcgtg ggcagcctgg ccatcctgag     1680

cactgaagtg tccgtgctgc tgctgacctt cctgaccctg gaaaagtaca tctgcatcgt     1740

gtaccctttc agatgcgtgc ggcctggcaa gtgccggacc atcacagtgc tgatcctgat     1800

ttggatcacc ggcttcatcg tggccttcat ccccctgagc aacaaagagt tcttcaagaa     1860

ttactacggc accaatggcg tgtgcttccc actgcactcc gaggacacag agagcatcgg     1920

cgcccagatc tacagcgtgg ccatcttcct gggcatcaat ctggccgcct tcatcatcat     1980

cgtgttcagc tacggctcca tgttctactc cgtgcaccag agcgccatca ccgccaccga     2040

gatccggaac caagtgaaga aagagatgat cctggccaag cgcttcttct tcattgtgtt     2100

caccgacgcc ctgtgttgga ttccaatctt cgtcgtgaag ttcctgagcc tgctgcaggt     2160

ggaaatcccc ggcacaatca ccagctgggt cgtgatcttc atcctgccca tcaacagcgc     2220

cctgaaccct atcctgtaca ccctgaccac ccggcccttc aaagaaatga tccaccggtt     2280

ctggtacaac taccggcaga gaaagagcat ggacagcaag ggccagaaaa cctacgcccc     2340

tagcttcatc tgggtggaaa tgtggccact gcaggaaatg cctcccgaac tgatgaagcc     2400

cgacctgttc acctacccct gcgagatgag cctgatctcc cagagcaccc ggctgaacag     2460

ctactcctga taacggaccg gcgatagatg aagctcgctt tcttgctgtc caatttctat     2520

taaaggttcc tttgttccct aagtccaact actaaactgg gggatattat gaagggcctt     2580

gagcatctgg attctgccta ataaaaaaca tttattttca ttgcagctcg ctttcttgct     2640

gtccaatttc tattaaaggt tcctttgttc cctaagtcca actactaaac tgggggatat     2700

tatgaagggc cttgagcatc tggattctgc ctaataaaaa acatttattt tcattgcggc     2760

cgcaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2820

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2880

aaa                                                                   2883


<210> 37
<211> 2277
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 37
augacaagcg gcagcguguu cuucuacauc cugaucuucg gcaaguacuu cagccacggc       60

ggaggccagg acgugaagug uagccugggc uacuuccccu gcggcaacau caccaagugc      120

cugccccagc ugcugcacug caacggcgug gacgauugcg gcaaccaggc cgacgaggac      180

aacugcggcg acaacaaugg cuggucccug caguucgaua aguacuucgc cuccuacuac      240

aagaugacca gccaguaccc cuucgaggcc gagacaccug agugccucgu gggcucugug      300

ccugugcagu gucugugcca gggccuggaa cuggacugcg acgagacaaa ccugagagcc      360

gugcccagcg uguccagcaa cgugacagcc augagccugc aguggaaccu gauccggaag      420

cugccccccg acugcuucaa gaacuaccac gaccugcaga agcuguaucu gcagaacaac      480

aagaucaccu ccaucagcau cuacgccuuc cggggccuga acagccugac caagcuguac      540

cugagccaca accggaucac cuuucugaag cccggcgugu ucgaggaccu gcacagacug      600

gaauggcuga ucaucgagga caaucaccug agccggauca gcccccccac cuucuacggc      660

cugaacuccc ugauccugcu ggugcugaug aacaacgugc ugacccggcu gcccgacaag      720

ccccuguguc agcacaugcc cagacugcac uggcuggacc uggaaggcaa ccacauccac      780

aaccugcgga accugaccuu caucagcugc agcaaccuga ccgugcucgu gaugcggaag      840

aacaagauua accaccugaa cgagaacacc uucgcccccc ugcagaaacu ggacgagcug      900

gaucugggcu cuaacaagau cgagaaccug cccccucuga ucuucaagga ccugaaagag      960

cugagccagc ugaaccuguc cuacaacccc auccagaaga uccaggccaa ccaguucgac     1020

uaccucguga agcugaaguc ccugucccug gaagggaucg agaucagcaa cauccagcag     1080

cggauguucc ggccccugau gaaucugucc cacaucuacu ucaagaaguu ccaguacugc     1140

ggcuacgccc cccacgugcg gagcugcaag ccuaacacag acggcaucag cagccuggaa     1200

aaccugcugg ccuccaucau ccagcgggug uucguguggg ugguguccgc cgugaccugc     1260

uucggcaaua ucuucgugau cugcaugcgg cccuacauuc ggagcgagaa caagcuguau     1320

gccaugagca ucaucucccu gugcugcgcc gacugccuga ugggcaucua ccuguucgug     1380

aucggcggcu ucgaccugaa guuccggggc gaguacaaca agcacgccca gcuguggaug     1440

gaaagcaccc acugccagcu cgugggcagc cuggccaucc ugagcacuga aguguccgug     1500

cugcugcuga ccuuccugac ccuggaaaag uacaucugca ucguguaccc uuucagaugc     1560

gugcggccug gcaagugccg gaccaucaca gugcugaucc ugauuuggau caccggcuuc     1620

aucguggccu ucaucccccu gagcaacaaa gaguucuuca agaauuacua cggcaccaau     1680

ggcgugugcu ucccacugca cuccgaggac acagagagca ucggcgccca gaucuacagc     1740

guggccaucu uccugggcau caaucuggcc gccuucauca ucaucguguu cagcuacggc     1800

uccauguucu acuccgugca ccagagcgcc aucaccgcca ccgagauccg gaaccaagug     1860

aagaaagaga ugauccuggc caagcgcuuc uucuucauug uguucaccga cgcccugugu     1920

uggauuccaa ucuucgucgu gaaguuccug agccugcugc agguggaaau ccccggcaca     1980

aucaccagcu gggucgugau cuucauccug cccaucaaca gcgcccugaa cccuauccug     2040

uacacccuga ccacccggcc cuucaaagaa augauccacc gguucuggua caacuaccgg     2100

cagagaaaga gcauggacag caagggccag aaaaccuacg ccccuagcuu caucugggug     2160

gaaauguggc cacugcagga aaugccuccc gaacugauga agcccgaccu guucaccuac     2220

cccugcgaga ugagccugau cucccagagc acccggcuga acagcuacuc cugauaa        2277


<210> 38
<211> 1786
<212> DNA
<213> Homo sapiens

<400> 38
gggcgggact tccggtcgtg ggccatgccg ggggcgggcc cggaaccgcc acggctagaa       60

gaagtcttca cttcccagga gagccaaagc gtgtctggcc ctaggtggga aaagaactgg      120

ctgtgacctt tgccctgacc tggaagggcc cagccttggg ctgaatggca gcacccacgc      180

ccgcccgtcc ggtgctgacc cacctgctgg tggctctctt cggcatgggc tcctgggctg      240

cggtcaatgg gatctgggtg gagctacctg tggtggtcaa agagcttcca gagggttgga      300

gcctcccctc ttacgtctct gtgcttgtgg ctctggggaa cctgggtctg ctggtggtga      360

ccctctggag gaggctggcc ccaggaaagg acgagcaggt ccccatccgg gtggtgcagg      420

tgctgggcat ggtgggcaca gccctgctgg cctctctgtg gcaccatgtg gccccagtgg      480

caggacagtt gcattctgtg gccttcttag cactggcctt tgtgctggca ctggcatgct      540

gtgcctcgaa tgtcactttc ctgcccttct tgagccacct gccacctcgc ttcttacggt      600

cattcttcct gggtcaaggc ctgagtgccc tgctgccctg cgtgctggcc ctagtgcagg      660

gtgtgggccg cctcgagtgc ccgccagccc ccatcaacgg cacccctggc cccccgctcg      720

acttccttga gcgttttccc gccagcacct tcttctgggc actgactgcc cttctggtcg      780

cttcagctgc tgccttccag ggtcttctgc tgctgttgcc gccaccacca tctgtaccca      840

caggggagtt aggatcaggc ctccaggtgg gagccccagg agcagaggaa gaggtggaag      900

agtcctcacc actgcaagag ccaccaagcc aggcagcagg caccacccct ggtccagacc      960

ctaaggccta tcagcttcta tcagcccgca gtgcctgcct gctgggcctg ttggccgcca     1020

ccaacgcgct gaccaatggc gtgctgcctg ccgtgcagag cttttcctgc ttaccctacg     1080

ggcgtctggc ctaccacctg gctgtggtgc tgggcagtgc tgccaatccc ctggcctgct     1140

tcctggccat gggtgtgctg tgcaggtcct tggcagggct gggcggcctc tctctgctgg     1200

gcgtgttctg tgggggctac ctgatggcgc tggcagtcct gagcccctgc ccgcccctgg     1260

tgggcacctc ggcgggggtg gtcctcgtgg tgctgtcgtg ggtgctgtgt cttggcgtgt     1320

tctcctacgt gaaggtggca gccagctccc tgctgcatgg cgggggccgg ccggcattgc     1380

tggcagccgg cgtggccatc caggtgggct ctctgctcgg cgctgttgct atgttccccc     1440

cgaccagcat ctatcacgtg ttccacagca gaaaggactg tgcagacccc tgtgactcct     1500

gagcctgggc aggtggggac cccgctcccc aacacctgtc tttccctcaa tgctgccacc     1560

atgcctgagt gcctgcagcc caggaggccc gcacaccggt acactcgtgg acacctacac     1620

actccatagg agatcctggc tttccagggt gggcaagggc aaggagcagg cttggagcca     1680

gggaccagtg ggggctgtag ggtaagcccc tgagcctggg acctacatgt ggtttgcgta     1740

ataaaacatt tgtatttaat gagttggcat taaaaaaaaa aaaaaa                    1786


<210> 39
<211> 1950
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 39
ggatccggag gccggagaat tgtaatacga ctcactatag ggagacgcgt gttaaataac       60

aaatctcaac acaacatata caaaacaaac gaatctcaag caatcaagca ttctacttct      120

attgcagcaa tttaaatcat ttcttttaaa gcaaaagcaa ttttctgaaa attttcacca      180

tttacgaacg atagccgcca ccatggcagc acccacgccc gcccgtccgg tgctgaccca      240

cctgctggtg gctctcttcg gcatgggctc ctgggctgcg gtcaatggga tctgggtgga      300

gctacctgtg gtggtcaaag agcttccaga gggttggagc ctcccctctt acgtctctgt      360

gcttgtggct ctggggaacc tgggtctgct ggtggtgacc ctctggagga ggctggcccc      420

aggaaaggac gagcaggtcc ccatccgggt ggtgcaggtg ctgggcatgg tgggcacagc      480

cctgctggcc tctctgtggc accatgtggc cccagtggca ggacagttgc attctgtggc      540

cttcttagca ctggcctttg tgctggcact ggcatgctgt gcctcgaatg tcactttcct      600

gcccttcttg agccacctgc cacctcgctt cttacggtca ttcttcctgg gtcaaggcct      660

gagtgccctg ctgccctgcg tgctggccct agtgcagggt gtgggccgcc tcgagtgccc      720

gccagccccc atcaacggca cccctggccc cccgctcgac ttccttgagc gttttcccgc      780

cagcaccttc ttctgggcac tgactgccct tctggtcgct tcagctgctg ccttccaggg      840

tcttctgctg ctgttgccgc caccaccatc tgtacccaca ggggagttag gatcaggcct      900

ccaggtggga gccccaggag cagaggaaga ggtggaagag tcctcaccac tgcaagagcc      960

accaagccag gcagcaggca ccacccctgg tccagaccct aaggcctatc agcttctatc     1020

agcccgcagt gcctgcctgc tgggcctgtt ggccgccacc aacgcgctga ccaatggcgt     1080

gctgcctgcc gtgcagagct tttcctgctt accctacggg cgtctggcct accacctggc     1140

tgtggtgctg ggcagtgctg ccaatcccct ggcctgcttc ctggcaatgg gtgtgctgtg     1200

caggtccttg gcagggctgg gcggcctctc tctgctgggc gtgttctgtg ggggctacct     1260

gatggcgctg gcagtcctga gcccctgccc gcccctggtg ggcacctcgg cgggggtggt     1320

cctcgtggtg ctgtcgtggg tgctgtgtct tggcgtgttc tcctacgtga aggtggcagc     1380

cagctccctg ctgcatggcg ggggccggcc ggcattgctg gcagccggcg tggccatcca     1440

ggtgggctct ctgctcggcg ctgttgctat gttccccccg accagcatct atcacgtgtt     1500

ccacagcaga aaggactgtg cagacccctg tgactcctga cggaccggcg atagatgaag     1560

ctcgctttct tgctgtccaa tttctattaa aggttccttt gttccctaag tccaactact     1620

aaactggggg atattatgaa gggccttgag catctggatt ctgcctaata aaaaacattt     1680

attttcattg cagctcgctt tcttgctgtc caatttctat taaaggttcc tttgttccct     1740

aagtccaact actaaactgg gggatattat gaagggcctt gagcatctgg attctgccta     1800

ataaaaaaca tttattttca ttgcggccgc aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1860

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                                      1950


<210> 40
<211> 1338
<212> RNA
<213> Homo sapiens

<400> 40
auggcagcac ccacgcccgc ccguccggug cugacccacc ugcugguggc ucucuucggc       60

augggcuccu gggcugcggu caaugggauc uggguggagc uaccuguggu ggucaaagag      120

cuuccagagg guuggagccu ccccucuuac gucucugugc uuguggcucu ggggaaccug      180

ggucugcugg uggugacccu cuggaggagg cuggccccag gaaaggacga gcaggucccc      240

auccgggugg ugcaggugcu gggcauggug ggcacagccc ugcuggccuc ucuguggcac      300

cauguggccc caguggcagg acaguugcau ucuguggccu ucuuagcacu ggccuuugug      360

cuggcacugg caugcugugc cucgaauguc acuuuccugc ccuucuugag ccaccugcca      420

ccucgcuucu uacggucauu cuuccugggu caaggccuga gugcccugcu gcccugcgug      480

cuggcccuag ugcagggugu gggccgccuc gagugcccgc cagcccccau caacggcacc      540

ccuggccccc cgcucgacuu ccuugagcgu uuucccgcca gcaccuucuu cugggcacug      600

acugcccuuc uggucgcuuc agcugcugcc uuccaggguc uucugcugcu guugccgcca      660

ccaccaucug uacccacagg ggaguuagga ucaggccucc aggugggagc cccaggagca      720

gaggaagagg uggaagaguc cucaccacug caagagccac caagccaggc agcaggcacc      780

accccugguc cagacccuaa ggccuaucag cuucuaucag cccgcagugc cugccugcug      840

ggccuguugg ccgccaccaa cgcgcugacc aauggcgugc ugccugccgu gcagagcuuu      900

uccugcuuac ccuacgggcg ucuggccuac caccuggcug uggugcuggg cagugcugcc      960

aauccccugg ccugcuuccu ggcaaugggu gugcugugca gguccuuggc agggcugggc     1020

ggccucucuc ugcugggcgu guucuguggg ggcuaccuga uggcgcuggc aguccugagc     1080

cccugcccgc cccugguggg caccucggcg gggguggucc ucguggugcu gucgugggug     1140

cugugucuug gcguguucuc cuacgugaag guggcagcca gcucccugcu gcauggcggg     1200

ggccggccgg cauugcuggc agccggcgug gccauccagg ugggcucucu gcucggcgcu     1260

guugcuaugu uccccccgac cagcaucuau cacguguucc acagcagaaa ggacugugca     1320

gaccccugug acuccuga                                                   1338


<210> 41
<211> 888
<212> DNA
<213> Homo sapiens

<400> 41
ataccttaga ccctcagtca tgccagtgcc tgctctgtgc ctgctctggg ccctggcaat       60

ggtgacccgg cctgcctcag cggcccccat gggcggccca gaactggcac agcatgagga      120

gctgaccctg ctcttccatg ggaccctgca gctgggccag gccctcaacg gtgtgtacag      180

gaccacggag ggacggctga caaaggccag gaacagcctg ggtctctatg gccgcacaat      240

agaactcctg gggcaggagg tcagccgggg ccgggatgca gcccaggaac ttcgggcaag      300

cctgttggag actcagatgg aggaggatat tctgcagctg caggcagagg ccacagctga      360

ggtgctgggg gaggtggccc aggcacagaa ggtgctacgg gacagcgtgc agcggctaga      420

agtccagctg aggagcgcct ggctgggccc tgcctaccga gaatttgagg tcttaaaggc      480

tcacgctgac aagcagagcc acatcctatg ggccctcaca ggccacgtgc agcggcagag      540

gcgggagatg gtggcacagc agcatcggct gcgacagatc caggagagac tccacacagc      600

ggcgctccca gcctgaatct gcctggatgg aactgaggac caatcatgct gcaaggaaca      660

cttccacgcc ccgtgaggcc cctgtgcagg gaggagctgc ctgttcactg ggatcagcca      720

gggcgccggg ccccacttct gagcacagag cagagacaga cgcaggcggg gacaaaggca      780

gaggatgtag ccccattggg gaggggtgga ggaaggacat gtaccctttc atgcctacac      840

acccctcatt aaagcagagt cgtggcatct caaaaaaaaa aaaaaaaa                   888


<210> 42
<211> 1306
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 42
gggatccgga ggccggagaa ttgtaatacg actcactata gggagacgcg tgttaaataa       60

caaatctcaa cacaacatat acaaaacaaa cgaatctcaa gcaatcaagc attctacttc      120

tattgcagca atttaaatca tttcttttaa agcaaaagca attttctgaa aattttcacc      180

atttacgaac gatagccgcc accatgaaga ccttcatcct gctgctgtgg gtgctgctgc      240

tgtgggtcat cttcctgctg cctggcgcca cagccgctcc tatgggagga cctgaactgg      300

cccagcacga ggaactgacc ctgctgtttc acggcaccct gcagctggga caggccctga      360

atggcgtgta cagaaccacc gagggccggc tgaccaaggc cagaaatagc ctgggcctgt      420

acggccggac catcgaactg ctggggcagg aagtgtccag aggcagagat gccgcccagg      480

aactgagagc cagcctgctg gaaacccaga tggaagagga catcctgcag ctgcaggccg      540

aggccacagc tgaggtgctg ggagaagtgg cccaggccca gaaggtgctg agagacagcg      600

tgcagcggct ggaagtgcag ctgagatctg cctggctggg ccctgcctac cgcgagttcg      660

aagtgctgaa agcccacgcc gacaagcaga gccacatcct gtgggccctg acaggccacg      720

tgcagagaca gaggcgggaa atggtggctc agcagcacag actgcggcag atccaggaac      780

ggctgcatac agctgccctg cccgccgact acaaggacga cgacgacaag caccaccacc      840

atcaccacgg cggaggcctg aacgacatct tcgaagccca gaaaatcgag tggcacgagt      900

aacggaccgg cgatagatga agctcgcttt cttgctgtcc aatttctatt aaaggttcct      960

ttgttcccta agtccaacta ctaaactggg ggatattatg aagggccttg agcatctgga     1020

ttctgcctaa taaaaaacat ttattttcat tgcagctcgc tttcttgctg tccaatttct     1080

attaaaggtt cctttgttcc ctaagtccaa ctactaaact gggggatatt atgaagggcc     1140

ttgagcatct ggattctgcc taataaaaaa catttatttt cattgcaaaa aaaaaaaaaa     1200

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa                    1306


<210> 43
<211> 699
<212> RNA
<213> Homo sapiens

<400> 43
augaagaccu ucauccugcu gcugugggug cugcugcugu gggucaucuu ccugcugccu       60

ggcgccacag ccgcuccuau gggaggaccu gaacuggccc agcacgagga acugacccug      120

cuguuucacg gcacccugca gcugggacag gcccugaaug gcguguacag aaccaccgag      180

ggccggcuga ccaaggccag aaauagccug ggccuguacg gccggaccau cgaacugcug      240

gggcaggaag uguccagagg cagagaugcc gcccaggaac ugagagccag ccugcuggaa      300

acccagaugg aagaggacau ccugcagcug caggccgagg ccacagcuga ggugcuggga      360

gaaguggccc aggcccagaa ggugcugaga gacagcgugc agcggcugga agugcagcug      420

agaucugccu ggcugggccc ugccuaccgc gaguucgaag ugcugaaagc ccacgccgac      480

aagcagagcc acauccugug ggcccugaca ggccacgugc agagacagag gcgggaaaug      540

guggcucagc agcacagacu gcggcagauc caggaacggc ugcauacagc ugcccugccc      600

gccgacuaca aggacgacga cgacaagcac caccaccauc accacggcgg aggccugaac      660

gacaucuucg aagcccagaa aaucgagugg cacgaguaa                             699


<210> 44
<211> 4410
<212> DNA
<213> Homo sapiens

<400> 44
cctcctccac agtggtgagg tcacagcccc ttggagccct ccctcttccc acccctcccg       60

ctcccgggtc tcctttggcc tggggtaacc cgaggtgcag agctgagaat gaggcgattt      120

cggaggatgg agaaatagcc ccgagtcccg tggaaaatga ggccggcgga cttgctgcag      180

ctggtgctgc tgctcgacct gcccagggac ctgggcggaa tggggtgttc gtctccaccc      240

tgcgagtgcc atcaggagga ggacttcaga gtcacctgca aggatattca acgcatcccc      300

agcttaccgc ccagtacgca gactctgaag cttattgaga ctcacctgag aactattcca      360

agtcatgcat tttctaatct gcccaatatt tccagaatct acgtatctat agatgtgact      420

ctgcagcagc tggaatcaca ctccttctac aatttgagta aagtgactca catagaaatt      480

cggaatacca ggaacttaac ttacatagac cctgatgccc tcaaagagct ccccctccta      540

aagttccttg gcattttcaa cactggactt aaaatgttcc ctgacctgac caaagtttat      600

tccactgata tattctttat acttgaaatt acagacaacc cttacatgac gtcaatccct      660

gtgaatgctt ttcagggact atgcaatgaa accttgacac tgaagctgta caacaatggc      720

tttacttcag tccaaggata tgctttcaat gggacaaagc tggatgctgt ttacctaaac      780

aagaataaat acctgacagt tattgacaaa gatgcatttg gaggagtata cagtggacca      840

agcttgctgg acgtgtctca aaccagtgtc actgcccttc catccaaagg cctggagcac      900

ctgaaggaac tgatagcaag aaacacctgg actcttaaga aacttccact ttccttgagt      960

ttccttcacc tcacacgggc tgacctttct tacccaagcc actgctgtgc ttttaagaat     1020

cagaagaaaa tcagaggaat ccttgagtcc ttgatgtgta atgagagcag tatgcagagc     1080

ttgcgccaga gaaaatctgt gaatgccttg aatagccccc tccaccagga atatgaagag     1140

aatctgggtg acagcattgt tgggtacaag gaaaagtcca agttccagga tactcataac     1200

aacgctcatt attacgtctt ctttgaagaa caagaggatg agatcattgg ttttggccag     1260

gagctcaaaa acccccagga agagactcta caagcttttg acagccatta tgactacacc     1320

atatgtgggg acagtgaaga catggtgtgt acccccaagt ccgatgagtt caacccgtgt     1380

gaagacataa tgggctacaa gttcctgaga attgtggtgt ggttcgttag tctgctggct     1440

ctcctgggca atgtctttgt cctgcttatt ctcctcacca gccactacaa actgaacgtc     1500

ccccgctttc tcatgtgcaa cctggccttt gcggatttct gcatggggat gtacctgctc     1560

ctcatcgcct ctgtagacct ctacactcac tctgagtact acaaccatgc catcgactgg     1620

cagacaggcc ctgggtgcaa cacggctggt ttcttcactg tctttgcaag cgagttatcg     1680

gtgtatacgc tgacggtcat caccctggag cgctggtatg ccatcacctt cgccatgcgc     1740

ctggaccgga agatccgcct caggcacgca tgtgccatca tggttggggg ctgggtttgc     1800

tgcttccttc tcgccctgct tcctttggtg ggaataagta gctatgccaa agtcagtatc     1860

tgcctgccca tggacaccga gacccctctt gctctggcat atattgtttt tgttctgacg     1920

ctcaacatag ttgccttcgt catcgtctgc tgctgttatg tgaagatcta catcacagtc     1980

cgaaatccgc agtacaaccc aggggacaaa gataccaaaa ttgccaagag gatggctgtg     2040

ttgatcttca ccgacttcat atgcatggcc ccaatctcat tctatgctct gtcagcaatt     2100

ctgaacaagc ctctcatcac tgttagcaac tccaaaatct tgctggtact cttctatcca     2160

cttaactcct gtgccaatcc attcctctat gctattttca ccaaggcctt ccagagggat     2220

gtgttcatcc tactcagcaa gtttggcatc tgtaaacgcc aggctcaggc ataccggggg     2280

cagagggttc ctccaaagaa cagcactgat attcaggttc aaaaggttac ccacgagatg     2340

aggcagggtc tccacaacat ggaagatgtc tatgaactga ttgaaaactc ccatctaacc     2400

ccaaagaagc aaggccaaat ctcagaagag tatatgcaaa cggttttgta agttaacact     2460

acactactca caatggtagg ggaacttaca aaataatagt ttcttgaata tgcattccaa     2520

tcccatgaca cccccaacac atagctgccc tcactcttgt gcaggcgatg tttcaatgtt     2580

tcatggggca agagtttatc tctggagagt gattagtatt aacctaatca ttgcccccaa     2640

gaaggaagtt aggctaccag catatttgaa tgccaggtga aatcaaaata atctacacta     2700

tctagaagac tttcttgatg ccaagtccag agatgtcatt gtgtaggatg ttcagtaaat     2760

attaactgag ctatgtcaat atagagcttc tcagttttgt ataacatttc atactaaaga     2820

ttcagcaaat ggaaaatgct attaatttgg ttggtgacca caagataaaa tcagtcccac     2880

gttggctcag ttcaactaga tgttccctga tacaaagaga acttgatttc cttaaaactg     2940

aaaagccaaa cacagctagc tgtcatacaa gaaacagcta ttatgagaca tgaaggaggg     3000

taagaattag ctttaagttt tgttttgctt tgttttgttt tttaactcaa cctattaatc     3060

atctcttcac aagaatccac ctgatgtgac caagctatta tgtgttgcct ggaaaaactg     3120

gcaagatttc agcttatgtg gcctagcaaa ctaagaattg ctcttcttgg ccagcctcat     3180

agcataaaag atgtgaactc taggaagtct ttctgagtag caataagtgg gaattatggg     3240

cagagcacac tcaatcccct gttgattaat aaaacaggct ggacactaat taactatggg     3300

acttaaatct gtagaaatga aggagtccaa tagcttcttc caattttaaa actctagtac     3360

atccctttcc ctcaaatata tatttctaag ataaagagaa agaagagcac taagtaagta     3420

gaatctgttt ttcctatttt gtagggctgc tgactcctag tccttgaagc ctagacacat     3480

gacccaggaa atttttcctt tgtttcactt ttgattatga tgtctgagcc aaaaattcaa     3540

ttaagtaaac atactcgcct ggatctgaat cattcattta attactagat ctacccagct     3600

gttatatcag gccaaaaaca gattcgtgtt tatataaaag agtaaacgat ggttgcaaat     3660

tttggctatt tagagttgct acttcactat gaagagtcac ttcaaaacac ttcgcttgtc     3720

tttagggatg atttttgcca tttccagtcc acggtatgat actaaagctg tcaagagagg     3780

tttcttcttt tctgaaactg ccagctcttt ccagccctgt tgatcactgg acataaagct     3840

tcttttcccc aataattctt ctttacttaa aatagtcagg atctttatct acagatgtac     3900

tctccaggtt acctgtgatg atagccccct aatgtcctgc tagaaaagtc tccaagcaga     3960

gatgacatta cttctgaatg ctcataaacc acaccatgaa ataaaagctc tttgttgttt     4020

taagattgtg aagtgtcgtt aatgggtccc cacagatggt ccctgctgga ctcacctgga     4080

atctctccac agccataccc actcatcact atcattgaga cctgcacatc ttaatagaaa     4140

tattataaac atcgaaaatc atgacttacc tagaagttcg cttgtaacta atgaaattaa     4200

acaaatgtgt tgccttttgt catgtgtttc tctcctgtga catttcaaaa tatcacatct     4260

tgataaataa tgtgtttcat cttgaatagc tgaactaatt gctttggaaa cagagtccta     4320

gaaaagtgac ttcaacagaa ttgttactaa aatttgcact cacaacatga aataaatttt     4380

cttcctatgg aataatcgtg aaaaaaaaaa                                      4410


<210> 45
<211> 2904
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 45
ggaggccgga gaattgtaat acgactcact atagggagac gcgtgttaaa taacaaatct       60

caacacaaca tatacaaaac aaacgaatct caagcaatca agcattctac ttctattgca      120

gcaatttaaa tcatttcttt taaagcaaaa gcaattttct gaaaattttc accatttacg      180

aacgatagcc gccaccatga ggcctgccga cctgctgcag ctggtgctgc tgctggacct      240

gcctagagat ctgggcggca tgggctgtag cagccctcca tgcgagtgcc accaggaaga      300

ggacttcaga gtgacctgca aggacatcca gagaatcccc agcctgcccc ccagcaccca      360

gaccctgaag ctgatcgaga cacacctgag aaccatccct agccacgcct tcagcaacct      420

gcccaacatc agcagaatct acgtgtccat cgacgtgacc ctgcagcagc tggaaagcca      480

cagcttctac aacctgagca aagtgaccca catcgagatc agaaacaccc ggaacctgac      540

ctacatcgac cccgacgccc tgaaagagct gcccctgctg aagttcctgg gcatcttcaa      600

caccggcctg aagatgttcc ccgacctgac caaggtgtac tctaccgaca tcttcttcat      660

cctggaaatc accgacaacc cctacatgac cagcatcccc gtgaacgcct tccagggcct      720

gtgcaacgag acactgacac tgaagctgta caacaacggc ttcaccagcg tgcagggcta      780

cgccttcaac ggcacaaagc tggacgccgt gtacctgaac aagaacaagt acctgaccgt      840

gatcgacaag gacgccttcg gcggcgtgta ctctggacct tctctgctgg acgtgtccca      900

gaccagcgtg acagccctgc ctagcaaggg cctggaacac ctgaaagaac tgatcgcccg      960

caacacctgg actctgaaga agctgcctct gagcctgagc ttcctgcacc tgaccagagc     1020

cgacctgagc tacccaagcc actgctgcgc cttcaagaac cagaagaaga tccggggaat     1080

cctggaatcc ctgatgtgta acgagagcag catgcagagc ctgagacaga gaaagtctgt     1140

gaacgctctg aacagccccc tgcaccagga atacgaggaa aacctgggcg acagcatcgt     1200

gggctacaaa gagaagtcca agttccagga cacccacaac aacgcccact actacgtgtt     1260

cttcgaggaa caggaagatg agatcatcgg cttcggccag gaactgaaga accctcagga     1320

agagacactg caggccttcg acagccacta cgactacacc atctgcggcg acagcgagga     1380

catggtgtgc acccctaaga gcgacgagtt caacccctgc gaggatatta tggggtacaa     1440

gttcctgagg atcgtcgtgt ggttcgtgtc cctgctggct ctgctgggca acgtgttcgt     1500

gctgctgatc ctgctgacct cccactacaa gctgaacgtg cccagattcc tgatgtgcaa     1560

cctggccttc gccgacttct gcatgggcat gtacctgctg ctgattgcca gcgtggacct     1620

gtacacccac agcgagtact acaaccacgc catcgactgg cagaccggcc ctggctgtaa     1680

caccgccggc tttttcaccg tgttcgccag cgagctgagc gtgtacaccc tgacagtgat     1740

caccctggaa aggtggtacg ccatcacctt cgccatgaga ctggacagaa agatcagact     1800

gagacacgcc tgcgccatca tggtgggagg ctgggtgtgc tgtttcctgc tggccctgct     1860

gcccctcgtg ggcatcagct cttacgccaa ggtgtccatc tgcctgccca tggacaccga     1920

gacacctctg gccctggcct acattgtgtt tgtgctgacc ctgaacatcg tggccttcgt     1980

gatcgtgtgc tgctgttacg tgaagatcta catcaccgtg cggaaccccc agtacaaccc     2040

cggcgacaag gataccaaga tcgccaagag aatggccgtg ctgatcttca ccgacttcat     2100

ctgcatggcc cccatcagct tctatgccct gagcgccatt ctgaacaagc ctctgatcac     2160

cgtgtccaac agcaaaatcc tgctggtgct gttctacccc ctgaacagct gcgccaaccc     2220

cttcctgtac gctatcttca ccaaggcctt ccagagggac gtgttcatcc tgctgtctaa     2280

gttcggcatc tgcaagagac aggcccaggc ctaccggggc cagagagtgc ctcctaagaa     2340

ctccacagac atccaggtgc agaaagtgac acacgacatg agacagggcc tgcacaacat     2400

ggaagatgtg tacgagctga ttgagaacag ccacctgacc cccaagaaac agggacagat     2460

cagcgaagag tacatgcaga ccgtgctgtg ataacggacc ggcgatagat gaagctcgct     2520

ttcttgctgt ccaatttcta ttaaaggttc ctttgttccc taagtccaac tactaaactg     2580

ggggatatta tgaagggcct tgagcatctg gattctgcct aataaaaaac atttattttc     2640

attgcagctc gctttcttgc tgtccaattt ctattaaagg ttcctttgtt ccctaagtcc     2700

aactactaaa ctgggggata ttatgaaggg ccttgagcat ctggattctg cctaataaaa     2760

aacatttatt ttcattgcgg ccgcaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2820

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2880

aaaaaaaaaa aaaaaaaaaa aaaa                                            2904


<210> 46
<211> 2298
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 46
augaggccug ccgaccugcu gcagcuggug cugcugcugg accugccuag agaucugggc       60

ggcaugggcu guagcagccc uccaugcgag ugccaccagg aagaggacuu cagagugacc      120

ugcaaggaca uccagagaau ccccagccug ccccccagca cccagacccu gaagcugauc      180

gagacacacc ugagaaccau cccuagccac gccuucagca accugcccaa caucagcaga      240

aucuacgugu ccaucgacgu gacccugcag cagcuggaaa gccacagcuu cuacaaccug      300

agcaaaguga cccacaucga gaucagaaac acccggaacc ugaccuacau cgaccccgac      360

gcccugaaag agcugccccu gcugaaguuc cugggcaucu ucaacaccgg ccugaagaug      420

uuccccgacc ugaccaaggu guacucuacc gacaucuucu ucauccugga aaucaccgac      480

aaccccuaca ugaccagcau ccccgugaac gccuuccagg gccugugcaa cgagacacug      540

acacugaagc uguacaacaa cggcuucacc agcgugcagg gcuacgccuu caacggcaca      600

aagcuggacg ccguguaccu gaacaagaac aaguaccuga ccgugaucga caaggacgcc      660

uucggcggcg uguacucugg accuucucug cuggacgugu cccagaccag cgugacagcc      720

cugccuagca agggccugga acaccugaaa gaacugaucg cccgcaacac cuggacucug      780

aagaagcugc cucugagccu gagcuuccug caccugacca gagccgaccu gagcuaccca      840

agccacugcu gcgccuucaa gaaccagaag aagauccggg gaauccugga aucccugaug      900

uguaacgaga gcagcaugca gagccugaga cagagaaagu cugugaacgc ucugaacagc      960

ccccugcacc aggaauacga ggaaaaccug ggcgacagca ucgugggcua caaagagaag     1020

uccaaguucc aggacaccca caacaacgcc cacuacuacg uguucuucga ggaacaggaa     1080

gaugagauca ucggcuucgg ccaggaacug aagaacccuc aggaagagac acugcaggcc     1140

uucgacagcc acuacgacua caccaucugc ggcgacagcg aggacauggu gugcaccccu     1200

aagagcgacg aguucaaccc cugcgaggau auuauggggu acaaguuccu gaggaucguc     1260

gugugguucg ugucccugcu ggcucugcug ggcaacgugu ucgugcugcu gauccugcug     1320

accucccacu acaagcugaa cgugcccaga uuccugaugu gcaaccuggc cuucgccgac     1380

uucugcaugg gcauguaccu gcugcugauu gccagcgugg accuguacac ccacagcgag     1440

uacuacaacc acgccaucga cuggcagacc ggcccuggcu guaacaccgc cggcuuuuuc     1500

accguguucg ccagcgagcu gagcguguac acccugacag ugaucacccu ggaaaggugg     1560

uacgccauca ccuucgccau gagacuggac agaaagauca gacugagaca cgccugcgcc     1620

aucauggugg gaggcugggu gugcuguuuc cugcuggccc ugcugccccu cgugggcauc     1680

agcucuuacg ccaagguguc caucugccug cccauggaca ccgagacacc ucuggcccug     1740

gccuacauug uguuugugcu gacccugaac aucguggccu ucgugaucgu gugcugcugu     1800

uacgugaaga ucuacaucac cgugcggaac ccccaguaca accccggcga caaggauacc     1860

aagaucgcca agagaauggc cgugcugauc uucaccgacu ucaucugcau ggcccccauc     1920

agcuucuaug cccugagcgc cauucugaac aagccucuga ucaccguguc caacagcaaa     1980

auccugcugg ugcuguucua cccccugaac agcugcgcca accccuuccu guacgcuauc     2040

uucaccaagg ccuuccagag ggacguguuc auccugcugu cuaaguucgg caucugcaag     2100

agacaggccc aggccuaccg gggccagaga gugccuccua agaacuccac agacauccag     2160

gugcagaaag ugacacacga caugagacag ggccugcaca acauggaaga uguguacgag     2220

cugauugaga acagccaccu gacccccaag aaacagggac agaucagcga agaguacaug     2280

cagaccgugc ugugauaa                                                   2298


<210> 47
<211> 3877
<212> DNA
<213> Homo sapiens

<400> 47
ggaaagccga cttgcaaaac cacagataat gttcagccca gcacagtagg ggtcaatttg       60

gtccacttgc tcagtgacaa aaagaaaaaa aaagtgggct gtcactaaag attttgactc      120

acaagagagg ggctggtctg gaggtgggag gagggagtga cgagtcaagg aggagacagg      180

gacgcaggag ggtgcaagga agtgtcttaa ctgagacggg ggtaaggcaa gagagggtgg      240

aggaaattct gcaggagaca ggcttcctcc agggtctgga gaacccagag gcagctcctc      300

ctgagtgctg ggaaggactc tgggcatctt cagcccttct tactctctga ggctcaagcc      360

agaaattcag gctgcttgca gagtgggtga cagagccacg gagctggtgt ccctgggacc      420

ctctgcccgt cttctctcca ctccccagca tggaggaagg tggtgatttt gacaactact      480

atggggcaga caaccagtct gagtgtgagt acacagactg gaaatcctcg ggggccctca      540

tccctgccat ctacatgttg gtcttcctcc tgggcaccac gggcaacggt ctggtgctct      600

ggaccgtgtt tcggagcagc cgggagaaga ggcgctcagc tgatatcttc attgctagcc      660

tggcggtggc tgacctgacc ttcgtggtga cgctgcccct gtgggctacc tacacgtacc      720

gggactatga ctggcccttt gggaccttct tctgcaagct cagcagctac ctcatcttcg      780

tcaacatgta cgccagcgtc ttctgcctca ccggcctcag cttcgaccgc tacctggcca      840

tcgtgaggcc agtggccaat gctcggctga ggctgcgggt cagcggggcc gtggccacgg      900

cagttctttg ggtgctggcc gccctcctgg ccatgcctgt catggtgtta cgcaccaccg      960

gggacttgga gaacaccact aaggtgcagt gctacatgga ctactccatg gtggccactg     1020

tgagctcaga gtgggcctgg gaggtgggcc ttggggtctc gtccaccacc gtgggctttg     1080

tggtgccctt caccatcatg ctgacctgtt acttcttcat cgcccaaacc atcgctggcc     1140

acttccgcaa ggaacgcatc gagggcctgc ggaagcggcg ccggctgctc agcatcatcg     1200

tggtgctggt ggtgaccttt gccctgtgct ggatgcccta ccacctggtg aagacgctgt     1260

acatgctggg cagcctgctg cactggccct gtgactttga cctcttcctc atgaacatct     1320

tcccctactg cacctgcatc agctacgtca acagctgcct caaccccttc ctctatgcct     1380

ttttcgaccc ccgcttccgc caggcctgca cctccatgct ctgctgtggc cagagcaggt     1440

gcgcaggcac ctcccacagc agcagtgggg agaagtcagc cagctactct tcggggcaca     1500

gccaggggcc cggccccaac atgggcaagg gtggagaaca gatgcacgag aaatccatcc     1560

cctacagcca ggagaccctt gtggttgact agggctggga gcagagagaa gcctggcgcc     1620

ctcggccctc cccggccttt gcccttgctt tctgaaaatc aggtagtgtg gctactcctt     1680

gtcctatgca catcctttaa ctgtcccctg attctgcccc gccctgtcct cctctactgc     1740

tttattcttt ctcagaggtt tgtggtttag gggaaagaga ctgggctcta cagacctgac     1800

cctgcacaag ccatttaatc tcactcagcc tcagtttctc cattggtatg aaatggggga     1860

aagtcatatt gatcctaaaa tgttgaagcc tgagtctgga cgcagtaaaa gcttgtttcc     1920

ctctgctgct ttcttagatc tgcaatcgtc tttcctccct tctttccttg tagtttttcc     1980

cccaccactc tctgcagctg ccgctcctta tccctgcctt ctggcaccaa tcccctccta     2040

cagctcgtcc ccctccctcc atccatcctt ctcccctgtc tactttcttg ttctgaaggg     2100

ctactaaggg ttaaggatcc caaagcttgc agagactgac cctgtttaag ctttctatcc     2160

tgttttctga gtgtgaggca gggaatgggc tggggccggg ggtgggctgt gtgtcagcag     2220

ataattagtg ctccagccct tagatctggg agctccagag cttgccctaa aattggatca     2280

cttccctgtc attttgggca ttggggctag tgtgattcct gcagttcccc catggcacca     2340

tgacactgac tagatatgct ttctccaaat tgtccgcaga ccctttcatc cttcctctat     2400

tttctatgag aattggaagg cagcagggct gatgaatgga tgtactcctt ggtttcatta     2460

tgtgagtggg gagttgggaa gggcaactag agagagagga tggaggggtg tctgcattta     2520

gtccagacac tgcttggctc gctccccgag tcctcctgtt tctgacttcc tgcataactg     2580

tgagctgaag ggtttcctca tctccccatc ttaccccatc atactgattt ctttcttggg     2640

cactggtgct acttggtgcc aagaatcatg ttgtttggga tggagatgcc tgcctcttgt     2700

ctgtgtgtgt tgtacttata tgtctatatg gatgagcctg gcatgaacag cagtgtgcct     2760

gggtcatttg gacaaacctc ctcccacccc ccaatccact gcaactctgc tgttcacaca     2820

ttacccttgg cagggggtgg tggggggcag ggacacactg aggcaatgaa aaatgtagaa     2880

taaaaatgag tccaccccct actggatttg ggggctccaa cggctggtcc gtgctttagg     2940

agcgaagtta atgtttgcac caggcttcct gtagggagat ccctccccaa agcagctggc     3000

gccaaggctt gggggcgtcc tactgagctg ggttcctgct ccttcttggg ctccatgaag     3060

gaagtaagag gctagttgag agcctccctt ggcccctttc cggtgcctcc ccgcctggct     3120

tcaaatttat gagcattgcc ctcatcgtcc tttcttgttc cagggtcagt ggccctcttc     3180

ctaaggaggc ctcctgcttg ccatgggcca aaaggcacgg ggtgggtttt ttctctccct     3240

accctcagga ttggacctct tggcttctgc tggattgggg atctgggaat agggactgga     3300

gcaagtgtgc agatagcatg atgtctacac tgccagagag accgtgagga tgaaattaat     3360

agtggggcct ttgtgagcta gaggctggga gtgtctattc cgggttttgt tcttggagga     3420

ctatgaaagt gaaggacaag acatgagcga tggagataag aaaagcccag cttgatgtga     3480

atggacatct tgaccctccc tggaatgacg ccagctctgg gggcagaggg aggaggagag     3540

gggaaggggc tcctcacagc ctagtctccc catcttaaga tagcatcttt cacagagtca     3600

cctcctctgc ccagagctgt cctcaaagca tccagtgaac actggaagag gcttctagaa     3660

gggaagaaat tgtccctctg aggccgccgt gggtgacctg cagagacttc ctgcctggaa     3720

ctcatctgtg aactgggaca gaagcagagg aggctgcctg ctgtgatacc cccttacctc     3780

ccccagtgcc ttcttcagaa tatctgcact gtcttctgat cctgttagtc actgtggttc     3840

atcaaataaa actgtttgtg caactgttgt gtccaaa                              3877


<210> 48
<211> 1749
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 48
ggaggccgga gaattgtaat acgactcact atagggagac gcgtgttaaa taacaaatct       60

caacacaaca tatacaaaac aaacgaatct caagcaatca agcattctac ttctattgca      120

gcaatttaaa tcatttcttt taaagcaaaa gcaattttct gaaaattttc accatttacg      180

aacgatagcc gccaccatgg aagagggcgg cgacttcgac aactactacg gcgccgacaa      240

ccagagcgag tgcgagtaca ccgactggaa gtcctctggc gccctgatcc ccgctatcta      300

catgctggtg tttctgctgg gcaccaccgg caacggactg gtgctgtgga ccgtgttcag      360

aagcagcaga gagaagcggc ggagcgccga catctttatc gccagcctgg ccgtggccga      420

cctgaccttt gtcgtgacac tgcctctgtg ggccacctac acctaccggg actacgactg      480

gcccttcggc acatttttct gcaagctgag cagctacctg atcttcgtga atatgtacgc      540

cagcgtgttc tgcctgaccg gcctgagctt cgacagatac ctggccatcg tgcggcccgt      600

ggccaacgct agactgcggc tgagagtgtc tggcgccgtg gctacagctg tgctgtgggt      660

gctggctgcc ctgctggcta tgcctgtgat ggtgctgaga accaccggcg acctggaaaa      720

caccaccaag gtgcagtgct acatggacta cagcatggtg gccacagtgt ccagcgagtg      780

ggcctgggaa gtgggactgg gagtgtctag caccaccgtg ggcttcgtgg tgcccttcac      840

cattatgctg acctgctact tcttcattgc ccagacaatc gccggccact tccggaaaga      900

gcggatcgag ggcctgcgga agagaaggcg gctgctgagc atcatcgtgg tgctggtcgt      960

gaccttcgcc ctgtgctgga tgccttacca cctcgtgaaa accctgtata tgctgggcag     1020

cctgctgcac tggccctgcg atttcgacct gttcctgatg aacatcttcc cctactgcac     1080

ctgtatcagc tacgtgaaca gctgcctgaa ccccttcctg tacgccttct tcgacccccg     1140

gttcagacag gcctgcacct ccatgctgtg ctgcggccag tctagatgcg ccggcacaag     1200

ccacagcagc agcggcgaga agtctgccag ctacagctct ggccacagcc agggcccagg     1260

ccccaatatg ggaaagggcg gagagcagat gcacgagaag tccatccctt acagccagga     1320

aaccctggtg gtggactgac ggaccggcga tagatgaagc tcgctttctt gctgtccaat     1380

ttctattaaa ggttcctttg ttccctaagt ccaactacta aactggggga tattatgaag     1440

ggccttgagc atctggattc tgcctaataa aaaacattta ttttcattgc agctcgcttt     1500

cttgctgtcc aatttctatt aaaggttcct ttgttcccta agtccaacta ctaaactggg     1560

ggatattatg aagggccttg agcatctgga ttctgcctaa taaaaaacat ttattttcat     1620

tgcggccgca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1680

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1740

aaaaaaaaa                                                             1749


<210> 49
<211> 1143
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 49
auggaagagg gcggcgacuu cgacaacuac uacggcgccg acaaccagag cgagugcgag       60

uacaccgacu ggaaguccuc uggcgcccug auccccgcua ucuacaugcu gguguuucug      120

cugggcacca ccggcaacgg acuggugcug uggaccgugu ucagaagcag cagagagaag      180

cggcggagcg ccgacaucuu uaucgccagc cuggccgugg ccgaccugac cuuugucgug      240

acacugccuc ugugggccac cuacaccuac cgggacuacg acuggcccuu cggcacauuu      300

uucugcaagc ugagcagcua ccugaucuuc gugaauaugu acgccagcgu guucugccug      360

accggccuga gcuucgacag auaccuggcc aucgugcggc ccguggccaa cgcuagacug      420

cggcugagag ugucuggcgc cguggcuaca gcugugcugu gggugcuggc ugcccugcug      480

gcuaugccug ugauggugcu gagaaccacc ggcgaccugg aaaacaccac caaggugcag      540

ugcuacaugg acuacagcau gguggccaca guguccagcg agugggccug ggaaguggga      600

cugggagugu cuagcaccac cgugggcuuc guggugcccu ucaccauuau gcugaccugc      660

uacuucuuca uugcccagac aaucgccggc cacuuccgga aagagcggau cgagggccug      720

cggaagagaa ggcggcugcu gagcaucauc guggugcugg ucgugaccuu cgcccugugc      780

uggaugccuu accaccucgu gaaaacccug uauaugcugg gcagccugcu gcacuggccc      840

ugcgauuucg accuguuccu gaugaacauc uuccccuacu gcaccuguau cagcuacgug      900

aacagcugcc ugaaccccuu ccuguacgcc uucuucgacc cccgguucag acaggccugc      960

accuccaugc ugugcugcgg ccagucuaga ugcgccggca caagccacag cagcagcggc     1020

gagaagucug ccagcuacag cucuggccac agccagggcc caggccccaa uaugggaaag     1080

ggcggagagc agaugcacga gaaguccauc ccuuacagcc aggaaacccu ggugguggac     1140

uga                                                                   1143


<210> 50
<211> 3085
<212> DNA
<213> Homo sapiens

<400> 50
gagcagccaa aaggcccgcg gagtcgcgct gggccgcccc ggcgcagctg aaccgggggc       60

cgcgcctgcc aggccgacgg gtctggccca gcctggcgcc aaggggttcg tgcgctgtgg      120

agacgcggag ggtcgaggcg gcgcggcctg agtgaaaccc aatggaaaaa gcatgacatt      180

tagaagtaga agacttagct tcaaatccct actccttcac ttactaattt tgtgatttgg      240

aaatatccgc gcaagatgtt gacgttgcag acttgggtag tgcaagcctt gtttattttc      300

ctcaccactg aatctacagg tgaacttcta gatccatgtg gttatatcag tcctgaatct      360

ccagttgtac aacttcattc taatttcact gcagtttgtg tgctaaagga aaaatgtatg      420

gattattttc atgtaaatgc taattacatt gtctggaaaa caaaccattt tactattcct      480

aaggagcaat atactatcat aaacagaaca gcatccagtg tcacctttac agatatagct      540

tcattaaata ttcagctcac ttgcaacatt cttacattcg gacagcttga acagaatgtt      600

tatggaatca caataatttc aggcttgcct ccagaaaaac ctaaaaattt gagttgcatt      660

gtgaacgagg ggaagaaaat gaggtgtgag tgggatggtg gaagggaaac acacttggag      720

acaaacttca ctttaaaatc tgaatgggca acacacaagt ttgctgattg caaagcaaaa      780

cgtgacaccc ccacctcatg cactgttgat tattctactg tgtattttgt caacattgaa      840

gtctgggtag aagcagagaa tgcccttggg aaggttacat cagatcatat caattttgat      900

cctgtatata aagtgaagcc caatccgcca cataatttat cagtgatcaa ctcagaggaa      960

ctgtctagta tcttaaaatt gacatggacc aacccaagta ttaagagtgt tataatacta     1020

aaatataaca ttcaatatag gaccaaagat gcctcaactt ggagccagat tcctcctgaa     1080

gacacagcat ccacccgatc ttcattcact gtccaagacc ttaaaccttt tacagaatat     1140

gtgtttagga ttcgctgtat gaaggaagat ggtaagggat actggagtga ctggagtgaa     1200

gaagcaagtg ggatcaccta tgaagataga ccatctaaag caccaagttt ctggtataaa     1260

atagatccat cccatactca aggctacaga actgtacaac tcgtgtggaa gacattgcct     1320

ccttttgaag ccaatggaaa aatcttggat tatgaagtga ctctcacaag atggaaatca     1380

catttacaaa attacacagt taatgccaca aaactgacag taaatctcac aaatgatcgc     1440

tatctagcaa ccctaacagt aagaaatctt gttggcaaat cagatgcagc tgttttaact     1500

atccctgcct gtgactttca agctactcac cctgtaatgg atcttaaagc attccccaaa     1560

gataacatgc tttgggtgga atggactact ccaagggaat ctgtaaagaa atatatactt     1620

gagtggtgtg tgttatcaga taaagcaccc tgtatcacag actggcaaca agaagatggt     1680

accgtgcatc gcacctattt aagagggaac ttagcagaga gcaaatgcta tttgataaca     1740

gttactccag tatatgctga tggaccagga agccctgaat ccataaaggc ataccttaaa     1800

caagctccac cttccaaagg acctactgtt cggacaaaaa aagtagggaa aaacgaagct     1860

gtcttagagt gggaccaact tcctgttgat gttcagaatg gatttatcag aaattatact     1920

atattttata gaaccatcat tggaaatgaa actgctgtga atgtggattc ttcccacaca     1980

gaatatacat tgtcctcttt gactagtgac acattgtaca tggtacgaat ggcagcatac     2040

acagatgaag gtgggaagga tggtccagaa ttcactttta ctaccccaaa gtttgctcaa     2100

ggagaaattg aagccatagt cgtgcctgtt tgcttagcat tcctattgac aactcttctg     2160

ggagtgctgt tctgctttaa taagcgagac ctaattaaaa aacacatctg gcctaatgtt     2220

ccagatcctt caaagagtca tattgcccag tggtcacctc acactcctcc aaggcacaat     2280

tttaattcaa aagatcaaat gtattcagat ggcaatttca ctgatgtaag tgttgtggaa     2340

atagaagcaa atgacaaaaa gccttttcca gaagatctga aatcattgga cctgttcaaa     2400

aaggaaaaaa ttaatactga aggacacagc agtggtattg gggggtcttc atgcatgtca     2460

tcttctaggc caagcatttc tagcagtgat gaaaatgaat cttcacaaaa cacttcgagc     2520

actgtccagt attctaccgt ggtacacagt ggctacagac accaagttcc gtcagtccaa     2580

gtcttctcaa gatccgagtc tacccagccc ttgttagatt cagaggagcg gccagaagat     2640

ctacaattag tagatcatgt agatggcggt gatggtattt tgcccaggca acagtacttc     2700

aaacagaact gcagtcagca tgaatccagt ccagatattt cacattttga aaggtcaaag     2760

caagtttcat cagtcaatga ggaagatttt gttagactta aacagcagat ttcagatcat     2820

atttcacaat cctgtggatc tgggcaaatg aaaatgtttc aggaagtttc tgcagcagat     2880

gcttttggtc caggtactga gggacaagta gaaagatttg aaacagttgg catggaggct     2940

gcgactgatg aaggcatgcc taaaagttac ttaccacaga ctgtacggca aggcggctac     3000

atgcctcagt gaaggactag tagttcctgc tacaacttca gcagtaccta taaagtaaag     3060

ctaaaatgat tttatctgtg aattc                                           3085


<210> 51
<211> 3367
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 51
gatccggagg ccggagaatt gtaatacgac tcactatagg gagacgcgtg ttaaataaca       60

aatctcaaca caacatatac aaaacaaacg aatctcaagc aatcaagcat tctacttcta      120

ttgcagcaat ttaaatcatt tcttttaaag caaaagcaat tttctgaaaa ttttcaccat      180

ttacgaacga tagccgccac cgcatcgtga acgagggcaa gaaaatgctg accctgcaga      240

cctggctggt gcaggccctg ttcatcttcc tgaccaccga gagcaccggc gagctgctgg      300

acccttgtgg ctacatcagc cccgagagcc ctgtggtgca gctgcatagc aacttcaccg      360

ccgtgtgcgt gctgaaagaa aagtgcatgg actacttcca cgtgaacgcc aactacatcg      420

tgtggaaaac aaaccacttc accatcccca aagagcagta caccatcatc aacagaaccg      480

ccagcagcgt gaccttcacc gatatcgcca gcctgaacat ccagctgacc tgcaacatcc      540

tgaccttcgg ccagctggaa cagaacgtgt acggcatcac aatcatcagc ggcctgcccc      600

ccgagaagcc caagaacctg agctgcatcg tgaacgaggg caagaaaatg agatgcgagt      660

gggacggcgg cagagagaca cacctggaaa caaacttcac cctgaagtcc gagtgggcca      720

cccacaagtt cgccgactgc aaggccaaga gggacacccc caccagctgt accgtggact      780

acagcaccgt gtacttcgtg aacatcgaag tgtgggtgga agccgagaac gccctgggca      840

aagtgaccag cgaccacatc aacttcgacc ctgtgtacaa agtgaagccc aacccccccc      900

acaacctgag cgtgatcaac agcgaggaac tgagcagcat cctgaagctg acatggacca      960

accccagcat caagtccgtg atcattctga agtacaacat ccagtaccgg accaaggacg     1020

ccagcacctg gtcccagatc cctccagagg acaccgcctc caccagatcc agcttcacag     1080

tgcaggacct gaagcctttc accgagtacg tgttcaggat tcggtgcatg aaggaagatg     1140

gcaagggcta ctggagcgat tggagcgagg aagccagcgg catcacctac gaggacagac     1200

cctctaaggc ccccagcttc tggtacaaga tcgaccccag ccacacccag ggctacagaa     1260

ccgtgcagct cgtgtggaaa accctgcccc cattcgaggc caacggcaag atcctggact     1320

acgaagtgac cctgaccaga tggaagtccc atctgcagaa ctacaccgtg aacgctacca     1380

agctgaccgt gaacctgaca aacgacagat acctggccac cctgaccgtg cggaacctcg     1440

tgggcaagtc tgatgccgcc gtgctgacca tccccgcatg cgattttcaa gccacccacc     1500

ccgtgatgga tctgaaggct ttccccaagg acaacatgct gtgggtggaa tggaccaccc     1560

ccagagaaag cgtgaaaaag tacatcctgg aatggtgtgt gctgagcgac aaggccccct     1620

gcatcaccga ttggcagcag gaagatggaa ccgtgcacag aacctacctg agaggcaacc     1680

tggccgagag caagtgctac ctgatcaccg tgacccccgt gtacgctgac ggccctggaa     1740

gccctgagag catcaaggcc tacctgaagc aggcccctcc cagcaaggga cctacagtgc     1800

ggaccaagaa agtgggcaag aacgaggccg tgctggaatg ggaccagctg cctgtggatg     1860

tgcagaacgg cttcatcaga aactacacca tcttctacag gaccatcatc ggcaacgaga     1920

cagccgtgaa cgtggacagc agccacacag agtacaccct gagcagcctg acctccgaca     1980

ccctgtatat ggtgcgaatg gccgcctaca ccgacgaggg cggaaaggat ggccccgagt     2040

tcaccttcac cacacctaag ttcgctcagg gcgagatcga ggccatcgtg gtgcctgtgt     2100

gtctggcttt cctgctgacc accctgctgg gcgtgctgtt ctgcttcaac aagcgggacc     2160

tgatcaagaa gcacatctgg cccaacgtgc ccgaccctag caagagccat atcgcccagt     2220

ggtcccccca caccccccct agacacaact tcaacagcaa ggaccagatg tacagcgacg     2280

gcaactttac agacgtgtcc gtggtggaaa tcgaggctaa cgataagaag cccttcccag     2340

aagatctgaa gtccctggat ctgttcaaga aagagaagat caacacagag ggccacagct     2400

ccggcatcgg cggcagctct tgtatgagca gcagcagacc tagcatcagc agcagcgacg     2460

agaacgagag cagccagaac acctctagca ccgtgcagta ctccaccgtg gtgcacagcg     2520

gctacagaca ccaggtgcca agcgtgcagg tgttcagcag aagcgagtcc acccagcccc     2580

tgctggacag cgaagagagg cctgaggatc tgcagctggt ggaccatgtg gacggcggag     2640

atggcatcct gcccagacag cagtacttca agcagaactg ctcccagcac gagtccagcc     2700

ccgacatcag ccacttcgag agaagcaaac aggtgtccag cgtgaacgaa gaggacttcg     2760

tgcggctgaa gcagcagatc agcgatcaca tctcccagag ctgcggcagc ggccagatga     2820

agatgttcca ggaagtgtcc gccgctgacg ccttcggacc tggaactgag ggccaggtgg     2880

aaagattcga gacagtgggc atggaagccg ccacagacga gggcatgcct aagagctacc     2940

tgccccagac tgtgcggcag ggcggctaca tgcctcagtg aagctcgctt tcttgctgtc     3000

caatttctat taaaggttcc tttgttccct aagtccaact actaaactgg gggatattat     3060

gaagggcctt gagcatctgg attctgccta ataaaaaaca tttattttca ttgcagctcg     3120

ctttcttgct gtccaatttc tattaaaggt tcctttgttc cctaagtcca actactaaac     3180

tgggggatat tatgaagggc cttgagcatc tggattctgc ctaataaaaa acatttattt     3240

tcattgcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3360

aaaaaaa                                                               3367


<210> 52
<211> 2757
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 52
augcugaccc ugcagaccug gcuggugcag gcccuguuca ucuuccugac caccgagagc       60

accggcgagc ugcuggaccc uuguggcuac aucagccccg agagcccugu ggugcagcug      120

cauagcaacu ucaccgccgu gugcgugcug aaagaaaagu gcauggacua cuuccacgug      180

aacgccaacu acaucgugug gaaaacaaac cacuucacca uccccaaaga gcaguacacc      240

aucaucaaca gaaccgccag cagcgugacc uucaccgaua ucgccagccu gaacauccag      300

cugaccugca acauccugac cuucggccag cuggaacaga acguguacgg caucacaauc      360

aucagcggcc ugccccccga gaagcccaag aaccugagcu gcaucgugaa cgagggcaag      420

aaaaugagau gcgaguggga cggcggcaga gagacacacc uggaaacaaa cuucacccug      480

aaguccgagu gggccaccca caaguucgcc gacugcaagg ccaagaggga cacccccacc      540

agcuguaccg uggacuacag caccguguac uucgugaaca ucgaagugug gguggaagcc      600

gagaacgccc ugggcaaagu gaccagcgac cacaucaacu ucgacccugu guacaaagug      660

aagcccaacc ccccccacaa ccugagcgug aucaacagcg aggaacugag cagcauccug      720

aagcugacau ggaccaaccc cagcaucaag uccgugauca uucugaagua caacauccag      780

uaccggacca aggacgccag caccuggucc cagaucccuc cagaggacac cgccuccacc      840

agauccagcu ucacagugca ggaccugaag ccuuucaccg aguacguguu caggauucgg      900

ugcaugaagg aagauggcaa gggcuacugg agcgauugga gcgaggaagc cagcggcauc      960

accuacgagg acagacccuc uaaggccccc agcuucuggu acaagaucga ccccagccac     1020

acccagggcu acagaaccgu gcagcucgug uggaaaaccc ugcccccauu cgaggccaac     1080

ggcaagaucc uggacuacga agugacccug accagaugga agucccaucu gcagaacuac     1140

accgugaacg cuaccaagcu gaccgugaac cugacaaacg acagauaccu ggccacccug     1200

accgugcgga accucguggg caagucugau gccgccgugc ugaccauccc cgcaugcgau     1260

uuucaagcca cccaccccgu gauggaucug aaggcuuucc ccaaggacaa caugcugugg     1320

guggaaugga ccacccccag agaaagcgug aaaaaguaca uccuggaaug gugugugcug     1380

agcgacaagg cccccugcau caccgauugg cagcaggaag auggaaccgu gcacagaacc     1440

uaccugagag gcaaccuggc cgagagcaag ugcuaccuga ucaccgugac ccccguguac     1500

gcugacggcc cuggaagccc ugagagcauc aaggccuacc ugaagcaggc cccucccagc     1560

aagggaccua cagugcggac caagaaagug ggcaagaacg aggccgugcu ggaaugggac     1620

cagcugccug uggaugugca gaacggcuuc aucagaaacu acaccaucuu cuacaggacc     1680

aucaucggca acgagacagc cgugaacgug gacagcagcc acacagagua cacccugagc     1740

agccugaccu ccgacacccu guauauggug cgaauggccg ccuacaccga cgagggcgga     1800

aaggauggcc ccgaguucac cuucaccaca ccuaaguucg cucagggcga gaucgaggcc     1860

aucguggugc cugugugucu ggcuuuccug cugaccaccc ugcugggcgu gcuguucugc     1920

uucaacaagc gggaccugau caagaagcac aucuggccca acgugcccga cccuagcaag     1980

agccauaucg cccagugguc cccccacacc cccccuagac acaacuucaa cagcaaggac     2040

cagauguaca gcgacggcaa cuuuacagac guguccgugg uggaaaucga ggcuaacgau     2100

aagaagcccu ucccagaaga ucugaagucc cuggaucugu ucaagaaaga gaagaucaac     2160

acagagggcc acagcuccgg caucggcggc agcucuugua ugagcagcag cagaccuagc     2220

aucagcagca gcgacgagaa cgagagcagc cagaacaccu cuagcaccgu gcaguacucc     2280

accguggugc acagcggcua cagacaccag gugccaagcg ugcagguguu cagcagaagc     2340

gaguccaccc agccccugcu ggacagcgaa gagaggccug aggaucugca gcugguggac     2400

cauguggacg gcggagaugg cauccugccc agacagcagu acuucaagca gaacugcucc     2460

cagcacgagu ccagccccga caucagccac uucgagagaa gcaaacaggu guccagcgug     2520

aacgaagagg acuucgugcg gcugaagcag cagaucagcg aucacaucuc ccagagcugc     2580

ggcagcggcc agaugaagau guuccaggaa guguccgccg cugacgccuu cggaccugga     2640

acugagggcc agguggaaag auucgagaca gugggcaugg aagccgccac agacgagggc     2700

augccuaaga gcuaccugcc ccagacugug cggcagggcg gcuacaugcc ucaguga        2757


<210> 53
<211> 1017
<212> DNA
<213> Homo sapiens

<400> 53
gagtatttga ggctcggagc caccgccccg ccggcgcccg cagcacctcc tcgccagcag       60

ccgtccggag ccagccaacg agcggaaaat ggcagacaat ttttcgctcc atgatgcgtt      120

atctgggtct ggaaacccaa accctcaagg atggcctggc gcatggggga accagcctgc      180

tggggcaggg ggctacccag gggcttccta tcctggggcc taccccgggc aggcaccccc      240

aggggcttat cctggacagg cacctccagg cgcctaccct ggagcacctg gagcttatcc      300

cggagcacct gcacctggag tctacccagg gccacccagc ggccctgggg cctacccatc      360

ttctggacag ccaagtgcca ccggagccta ccctgccact ggcccctatg gcgcccctgc      420

tgggccactg attgtgcctt ataacctgcc tttgcctggg ggagtggtgc ctcgcatgct      480

gataacaatt ctgggcacgg tgaagcccaa tgcaaacaga attgctttag atttccaaag      540

agggaatgat gttgccttcc actttaaccc acgcttcaat gagaacaaca ggagagtcat      600

tgtttgcaat acaaagctgg ataataactg gggaagggaa gaaagacagt cggttttccc      660

atttgaaagt gggaaaccat tcaaaataca agtactggtt gaacctgacc acttcaaggt      720

tgcagtgaat gatgctcact tgttgcagta caatcatcgg gttaaaaaac tcaatgaaat      780

cagcaaactg ggaatttctg gtgacataga cctcaccagt gcttcatata ccatgatata      840

atctgaaagg ggcagattaa aaaaaaaaaa agaatctaaa ccttacatgt gtaaaggttt      900

catgttcact gtgagtgaaa atttttacat tcatcaatat ccctcttgta agtcatctac      960

ttaataaata ttacagtgaa ttacctgtct caatatgtca aaaaaaaaaa aaaaaaa        1017


<210> 54
<211> 1364
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 54
gatccggagg ccggagaatt gtaatacgac tcactatagg gagacgcgtg ttaaataaca       60

aatctcaaca caacatatac aaaacaaacg aatctcaagc aatcaagcat tctacttcta      120

ttgcagcaat ttaaatcatt tcttttaaag caaaagcaat tttctgaaaa ttttcaccat      180

ttacgaacga tagccgccac catggccgac aacttcagcc tgcacgatgc cctgagcggc      240

agcggcaacc ctaatcctca gggatggcct ggcgcttggg gcaatcagcc tgctggcgct      300

ggcggatatc ctggcgcatc ttacccaggc gcttaccccg gacaggctcc tccaggcgca      360

tatccaggcc aggcacctcc tggggcttat cctggggcac ctggcgccta ccctggcgct      420

cctgctcctg gcgtgtaccc tggacctcct tctggacccg gcgcataccc tagctctggc      480

cagccatctg ctaccggcgc ctatccagcc acaggacctt atggcgctcc agccggacct      540

ctgatcgtgc cctacaacct gcctctgcct ggcggcgtgg tgcccagaat gctgatcaca      600

atcctgggca ccgtgaagcc caacgccaac agaatcgccc tggacttcca gaggggcaac      660

gacgtggcct tccacttcaa ccccagattc aacgagaaca atcggcgcgt gatcgtgtgc      720

aacaccaagc tggacaacaa ctggggcaga gaagaaagac agagcgtgtt cccattcgag      780

agcggcaagc cattcaagat ccaggtgctg gtggaacccg accacttcaa ggtggccgtg      840

aacgacgccc atctgctgca gtacaaccac agagtgaaga agctgaacga gatcagcaag      900

ctgggcatca gcggcgacat cgacctgacc agcgcctcct acaccatgat ctgacggacc      960

ggcgatagat gaagctcgct ttcttgctgt ccaatttcta ttaaaggttc ctttgttccc     1020

taagtccaac tactaaactg ggggatatta tgaagggcct tgagcatctg gattctgcct     1080

aataaaaaac atttattttc attgcagctc gctttcttgc tgtccaattt ctattaaagg     1140

ttcctttgtt ccctaagtcc aactactaaa ctgggggata ttatgaaggg ccttgagcat     1200

ctggattctg cctaataaaa aacatttatt ttcattgcgg ccgcaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1320

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa                      1364


<210> 55
<211> 1326
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 55
gggagacgcg uguuaaauaa caaaucucaa cacaacauau acaaaacaaa cgaaucucaa       60

gcaaucaagc auucuacuuc uauugcagca auuuaaauca uuucuuuuaa agcaaaagca      120

auuuucugaa aauuuucacc auuuacgaac gauagccgcc accauggccg acaacuucag      180

ccugcacgau gcccugagcg gcagcggcaa cccuaauccu cagggauggc cuggcgcuug      240

gggcaaucag ccugcuggcg cuggcggaua uccuggcgca ucuuacccag gcgcuuaccc      300

cggacaggcu ccuccaggcg cauauccagg ccaggcaccu ccuggggcuu auccuggggc      360

accuggcgcc uacccuggcg cuccugcucc uggcguguac ccuggaccuc cuucuggacc      420

cggcgcauac ccuagcucug gccagccauc ugcuaccggc gccuauccag ccacaggacc      480

uuauggcgcu ccagccggac cucugaucgu gcccuacaac cugccucugc cuggcggcgu      540

ggugcccaga augcugauca caauccuggg caccgugaag cccaacgcca acagaaucgc      600

ccuggacuuc cagaggggca acgacguggc cuuccacuuc aaccccagau ucaacgagaa      660

caaucggcgc gugaucgugu gcaacaccaa gcuggacaac aacuggggca gagaagaaag      720

acagagcgug uucccauucg agagcggcaa gccauucaag auccaggugc ugguggaacc      780

cgaccacuuc aagguggccg ugaacgacgc ccaucugcug caguacaacc acagagugaa      840

gaagcugaac gagaucagca agcugggcau cagcggcgac aucgaccuga ccagcgccuc      900

cuacaccaug aucugacgga ccggcgauag augaagcucg cuuucuugcu guccaauuuc      960

uauuaaaggu uccuuuguuc ccuaagucca acuacuaaac ugggggauau uaugaagggc     1020

cuugagcauc uggauucugc cuaauaaaaa acauuuauuu ucauugcagc ucgcuuucuu     1080

gcuguccaau uucuauuaaa gguuccuuug uucccuaagu ccaacuacua aacuggggga     1140

uauuaugaag ggccuugagc aucuggauuc ugccuaauaa aaaacauuua uuuucauugc     1200

ggccgcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1320

aaaaaa                                                                1326


<210> 56
<211> 753
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 56
auggccgaca acuucagccu gcacgaugcc cugagcggca gcggcaaccc uaauccucag       60

ggauggccug gcgcuugggg caaucagccu gcuggcgcug gcggauaucc uggcgcaucu      120

uacccaggcg cuuaccccgg acaggcuccu ccaggcgcau auccaggcca ggcaccuccu      180

ggggcuuauc cuggggcacc uggcgccuac ccuggcgcuc cugcuccugg cguguacccu      240

ggaccuccuu cuggacccgg cgcauacccu agcucuggcc agccaucugc uaccggcgcc      300

uauccagcca caggaccuua uggcgcucca gccggaccuc ugaucgugcc cuacaaccug      360

ccucugccug gcggcguggu gcccagaaug cugaucacaa uccugggcac cgugaagccc      420

aacgccaaca gaaucgcccu ggacuuccag aggggcaacg acguggccuu ccacuucaac      480

cccagauuca acgagaacaa ucggcgcgug aucgugugca acaccaagcu ggacaacaac      540

uggggcagag aagaaagaca gagcguguuc ccauucgaga gcggcaagcc auucaagauc      600

caggugcugg uggaacccga ccacuucaag guggccguga acgacgccca ucugcugcag      660

uacaaccaca gagugaagaa gcugaacgag aucagcaagc ugggcaucag cggcgacauc      720

gaccugacca gcgccuccua caccaugauc uga                                   753


<210> 57
<211> 10
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence

<400> 57
gccrccatgg                                                              10


<210> 58
<211> 8
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Kozak sequence

<400> 58
caaacatg                                                                 8


<210> 59
<211> 120
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 59
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120


<210> 60
<211> 500
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> misc_feature
<222> (1)..(500)
<223> This sequence may encompass between 1 and 500 nucleotides

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 60
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      240

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      480

aaaaaaaaaa aaaaaaaaaa                                                  500


