                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
       PRAG, Gali
 
<120>  BACTERIAL SYSTEMS FOR ANALYZING UBIQUITYLATED POLYPEPTIDES

<130>  70435

<150>  US 62/371,881
<151>  2016-08-08

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide

<400>  1

Cys Ser Leu Tyr Asp Lys Asp Thr Leu Val Gln Leu Val Glu Thr Gly 
1               5                   10                  15      


Gly Ala His Pro Leu Ser Arg Glu Pro Ile Thr Glu Ser Met Ile Met 
            20                  25                  30          


Arg 
    


<210>  2
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide

<400>  2

Cys Thr Leu Phe Asp Ala Ala Ala Phe Ser Arg Leu Val Gly Glu Gly 
1               5                   10                  15      


Leu Pro His Pro Leu Thr Arg Glu Pro Ile Thr Ala Ser Ile Ile Val 
            20                  25                  30          


Lys 
    


<210>  3
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic peptide

<400>  3

Cys Thr Leu Phe Asp Ala Ala Ala Phe Ser Arg Leu Val Gly Glu Gly 
1               5                   10                  15      


Leu Pro His Pro Leu Thr Arg Glu Pro Ile Thr Ala Ser Ile Ile Val 
            20                  25                  30          


Lys 
    


<210>  4
<211>  140
<212>  PRT
<213>  Artificial sequence

<220>
<223>  full length sequence of the NleG6-3 ligase

<400>  4

Met Glu Arg Arg Ala Val Ala Leu Glu Arg Gln Leu Asn Gly Gly Val 
1               5                   10                  15      


Asp Phe Leu Arg Ser Val Asn Asn Tyr Phe Gln Ser Val Met Ala Glu 
            20                  25                  30          


His Arg Glu Asn Lys Thr Ser Asn Lys Ile Leu Met Glu Lys Ile Asn 
        35                  40                  45              


Ser Cys Val Phe Gly Thr Asp Ser Asn His Phe Ser Cys Pro Glu Ser 
    50                  55                  60                  


Phe Leu Thr Cys Pro Ile Thr Leu Asp Thr Pro Ala Asn Gly Val Phe 
65                  70                  75                  80  


Met Arg Asn Ser Gln Gly Ala Glu Ile Cys Ser Leu Tyr Asp Lys Asp 
                85                  90                  95      


Thr Leu Val Gln Leu Val Glu Thr Gly Gly Ala His Pro Leu Ser Arg 
            100                 105                 110         


Glu Pro Ile Thr Glu Ser Met Ile Met Arg Lys Asp Glu Cys His Phe 
        115                 120                 125             


Asp Ser Lys Lys Glu Ser Phe Val Ala Ser Asp Ala 
    130                 135                 140 


<210>  5
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker amino acid sequence

<400>  5

Leu Ile Lys Ala Ala Gln Arg Ala Arg Glu Ala Glu Arg Asp Leu Ala 
1               5                   10                  15      


Ala Ala Val Ala Gln Ala Ala Ala Gly Gln Ala Val Pro Arg Ala Ala 
            20                  25                  30          


Pro Arg Gln 
        35  


<210>  6
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Flexible linker amino acid sequence

<400>  6

Gly Gly Ser Ala Gly Ser Gly Ser Gly Ala Gly Ser Gly Ser Gly Gly 
1               5                   10                  15      


Ser Ala Gly Ser Ser Gly Ser Ser Gly Ala Ser Ser Gly 
            20                  25                  


<210>  7
<211>  76
<212>  PRT
<213>  Artificial sequence

<220>
<223>  mammalian ubiquitin amino acid sequence

<400>  7

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly 
65                  70                  75      


<210>  8
<211>  75
<212>  PRT
<213>  Artificial sequence

<220>
<223>  yeast ubiquitin amino acid sequence

<400>  8

Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Ser Ser Asp Thr Ile Asp Asn Val Lys Ser Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser 
    50                  55                  60                  


Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly 
65                  70                  75  


<210>  9
<211>  1051
<212>  PRT
<213>  Triticum aestivum

<400>  9

Met Leu Pro Arg Lys Arg Glu Ile Val Ala Gly Glu Val Glu Asp Leu 
1               5                   10                  15      


Gln Lys Lys Thr Arg Ala Gly Glu Gly Glu Val Thr Arg Glu Glu Gly 
            20                  25                  30          


Asp Ala Ala Met Ala Gly Arg Gly Asn Glu Ile Asp Glu Asp Leu His 
        35                  40                  45              


Ser Arg Gln Leu Ala Val Tyr Gly Arg Glu Thr Met Lys Arg Leu Phe 
    50                  55                  60                  


Gly Ser Asn Val Leu Val Ser Gly Leu Gln Gly Leu Gly Ala Glu Ile 
65                  70                  75                  80  


Ala Lys Asn Leu Val Leu Ala Gly Val Lys Ser Val Thr Leu His Asp 
                85                  90                  95      


Asp Gly Asn Val Glu Leu Trp Asp Leu Ser Ser Asn Phe Phe Leu Ser 
            100                 105                 110         


Glu Asn Asp Val Gly Gln Asn Arg Ala Gln Ala Cys Val Gln Lys Leu 
        115                 120                 125             


Gln Glu Leu Asn Asn Ala Val Leu Val Ser Ala Leu Thr Gly Asp Leu 
    130                 135                 140                 


Thr Lys Glu His Leu Ser Lys Phe Gln Ala Val Val Phe Thr Asp Ile 
145                 150                 155                 160 


Ser Leu Asp Lys Ala Ile Glu Phe Asp Asp Tyr Cys His Ser Gln Gln 
                165                 170                 175     


Pro Pro Ile Ala Phe Ile Lys Ser Glu Val Arg Gly Leu Phe Gly Ser 
            180                 185                 190         


Val Phe Cys Asp Phe Gly Pro Glu Phe Thr Val Leu Asp Val Asp Gly 
        195                 200                 205             


Glu Glu Pro His Thr Gly Ile Val Ala Ser Ile Ser Asn Asp Asn Pro 
    210                 215                 220                 


Ala Leu Val Ser Cys Val Asp Asp Glu Arg Leu Glu Phe Gln Asp Gly 
225                 230                 235                 240 


Asp Leu Val Val Phe Ser Glu Val His Gly Met Thr Glu Leu Asn Asp 
                245                 250                 255     


Gly Lys Pro Arg Lys Val Lys Asn Ala Arg Pro Tyr Ser Phe Phe Leu 
            260                 265                 270         


Glu Glu Asp Thr Ser Ser Phe Gly Ala Tyr Val Arg Gly Gly Ile Val 
        275                 280                 285             


Thr Gln Val Lys Pro Pro Lys Val Ile Lys Phe Lys Pro Leu Lys Glu 
    290                 295                 300                 


Ala Met Ser Glu Pro Gly Glu Phe Leu Met Ser Asp Phe Ser Lys Phe 
305                 310                 315                 320 


Glu Arg Pro Pro Leu Leu His Leu Ala Phe Gln Ala Leu Asp Lys Phe 
                325                 330                 335     


Arg Thr Glu Leu Ser Arg Phe Pro Val Ala Gly Ser Thr Asp Asp Val 
            340                 345                 350         


Gln Arg Val Ile Glu Tyr Ala Ile Ser Ile Asn Asp Thr Leu Gly Asp 
        355                 360                 365             


Arg Lys Leu Glu Glu Ile Asp Lys Lys Leu Leu His His Phe Ala Ser 
    370                 375                 380                 


Gly Ser Arg Ala Val Leu Asn Pro Met Ala Ala Met Phe Gly Gly Ile 
385                 390                 395                 400 


Val Gly Gln Glu Val Val Lys Ala Cys Ser Gly Lys Phe His Pro Leu 
                405                 410                 415     


Tyr Gln Phe Phe Tyr Phe Asp Ser Val Glu Ser Leu Pro Val Asp Pro 
            420                 425                 430         


Leu Glu Pro Gly Asp Leu Lys Pro Lys Asn Ser Arg Tyr Asp Ala Gln 
        435                 440                 445             


Ile Ser Val Phe Gly Ser Lys Leu Gln Asn Lys Leu Glu Glu Ala Lys 
    450                 455                 460                 


Ile Phe Met Val Gly Ser Gly Ala Leu Gly Cys Glu Phe Leu Lys Asn 
465                 470                 475                 480 


Leu Ala Leu Met Gly Ile Ser Cys Ser Gln Asn Gly Asn Leu Thr Leu 
                485                 490                 495     


Thr Asp Asp Asp Val Ile Glu Lys Ser Asn Leu Ser Arg Gln Phe Leu 
            500                 505                 510         


Phe Arg Asp Trp Asn Ile Gly Gln Pro Lys Ser Thr Val Ala Ala Thr 
        515                 520                 525             


Ala Ala Met Val Ile Asn Pro Lys Leu His Val Glu Ala Leu Gln Asn 
    530                 535                 540                 


Arg Ala Ser Pro Glu Thr Glu Asn Val Phe Asn Asp Ala Phe Trp Glu 
545                 550                 555                 560 


Asn Leu Asp Ala Val Val Asn Ala Leu Asp Asn Val Thr Ala Arg Met 
                565                 570                 575     


Tyr Ile Asp Ser Arg Cys Val Tyr Phe Gln Lys Pro Leu Leu Glu Ser 
            580                 585                 590         


Gly Thr Leu Gly Ala Lys Cys Asn Thr Gln Met Val Ile Pro His Leu 
        595                 600                 605             


Thr Glu Asn Tyr Gly Ala Ser Arg Asp Pro Pro Glu Lys Gln Ala Pro 
    610                 615                 620                 


Met Cys Thr Val His Ser Phe Pro His Asn Ile Asp His Cys Leu Thr 
625                 630                 635                 640 


Trp Ala Arg Ser Glu Phe Glu Gly Leu Leu Glu Lys Thr Pro Thr Glu 
                645                 650                 655     


Val Asn Ala Phe Leu Ser Asn Pro Thr Thr Tyr Ile Ser Ala Ala Arg 
            660                 665                 670         


Thr Ala Gly Asp Ala Gln Ala Arg Asp Gln Leu Glu Arg Val Ile Glu 
        675                 680                 685             


Cys Leu Asp Arg Asp Lys Cys Glu Thr Phe Gln Asp Ser Ile Thr Trp 
    690                 695                 700                 


Ala Arg Leu Lys Phe Glu Asp Tyr Phe Ser Asn Arg Val Lys Gln Leu 
705                 710                 715                 720 


Thr Phe Thr Phe Pro Glu Asp Ser Met Thr Ser Ser Gly Ala Pro Phe 
                725                 730                 735     


Trp Ser Ala Pro Lys Arg Phe Pro Arg Pro Val Glu Phe Ser Ser Ser 
            740                 745                 750         


Asp Gln Ser Gln Leu Ser Phe Ile Leu Ala Ala Ala Ile Leu Arg Ala 
        755                 760                 765             


Glu Thr Phe Gly Ile Pro Ile Pro Glu Trp Ala Lys Thr Pro Asn Lys 
    770                 775                 780                 


Leu Ala Ala Glu Ala Val Asp Lys Val Ile Val Pro Asp Phe Gln Pro 
785                 790                 795                 800 


Lys Gln Gly Val Lys Ile Val Thr His Glu Lys Ala Thr Ser Leu Ser 
                805                 810                 815     


Ser Ala Ser Val Asp Asp Ala Ala Val Ile Glu Glu Leu Ile Ala Lys 
            820                 825                 830         


Leu Glu Glu Val Ser Lys Thr Leu Pro Ser Gly Phe His Met Asn Pro 
        835                 840                 845             


Ile Gln Phe Glu Lys Asp Asp Asp Thr Asn Phe His Met Asp Val Ile 
    850                 855                 860                 


Ala Gly Phe Ala Asn Met Arg Ala Arg Asn Tyr Ser Ile Pro Glu Val 
865                 870                 875                 880 


Asp Lys Leu Lys Ala Lys Phe Ile Ala Gly Arg Ile Ile Pro Ala Ile 
                885                 890                 895     


Ala Thr Ser Thr Ala Met Ala Thr Gly Leu Val Cys Leu Glu Leu Tyr 
            900                 905                 910         


Lys Ala Leu Ala Gly Gly His Lys Val Glu Asp Tyr Arg Asn Thr Phe 
        915                 920                 925             


Ala Asn Leu Ala Ile Pro Leu Phe Ser Ile Ala Glu Pro Val Pro Pro 
    930                 935                 940                 


Lys Thr Ile Lys His Gln Glu Leu Ser Trp Thr Val Trp Asp Arg Trp 
945                 950                 955                 960 


Thr Val Thr Gly Asn Ile Thr Leu Arg Glu Leu Leu Glu Trp Leu Lys 
                965                 970                 975     


Glu Lys Gly Leu Asn Ala Tyr Ser Ile Ser Cys Gly Thr Ser Leu Leu 
            980                 985                 990         


Tyr Asn Ser Met Phe Pro Arg His  Lys Glu Arg Leu Asp  Arg Lys Val 
        995                 1000                 1005             


Val Asp  Val Ala Arg Glu Val  Ala Lys Met Glu Val  Pro Ser Tyr 
    1010                 1015                 1020             


Arg Arg  His Leu Asp Val Val  Val Ala Cys Glu Asp  Asp Asp Asp 
    1025                 1030                 1035             


Asn Asp  Val Asp Ile Pro Leu  Val Ser Val Tyr Phe  Arg 
    1040                 1045                 1050     


<210>  10
<211>  1053
<212>  PRT
<213>  Triticum aestivum

<400>  10

Met Leu Pro Ser Lys Arg Pro Ser Asp Ala Ala Ala Gly Asp Glu Asn 
1               5                   10                  15      


Gly Arg Gly Gly Asp Ala Arg Gly Pro Gly Ser Gly Arg Arg Arg Ala 
            20                  25                  30          


Arg Ala Ala Ala Gly Ala Val Thr Ala Ala Pro Gln Glu Ile Asp Glu 
        35                  40                  45              


Asp Leu His Ser Arg Gln Leu Ala Val Tyr Gly Arg Glu Thr Met Arg 
    50                  55                  60                  


Arg Leu Phe Ala Ser Asp Val Leu Val Ser Gly Leu Asn Gly Leu Gly 
65                  70                  75                  80  


Ala Glu Ile Ala Lys Asn Leu Ala Leu Ala Gly Val Lys Ser Val Thr 
                85                  90                  95      


Ile His Asp Val Lys Thr Val Lys Met Trp Asp Leu Ser Gly Asn Phe 
            100                 105                 110         


Phe Leu Ser Glu Asp Asp Ile Gly Lys Asn Arg Ala Ala Ala Cys Val 
        115                 120                 125             


Ala Lys Leu Gln Glu Leu Asn Asn Ala Val Leu Ile Ser Ala Leu Thr 
    130                 135                 140                 


Glu Glu Leu Thr Thr Glu His Leu Ser Lys Phe Gln Ala Val Val Phe 
145                 150                 155                 160 


Thr Asp Ile Asp Leu Asp Lys Ala Tyr Glu Phe Asp Asp Tyr Cys His 
                165                 170                 175     


Asn His Gln Pro Pro Ile Ser Phe Ile Lys Ser Glu Val Cys Gly Leu 
            180                 185                 190         


Phe Gly Ser Val Phe Cys Asp Phe Gly Pro Lys Phe Thr Val Leu Asp 
        195                 200                 205             


Val Asp Gly Glu Asp Pro His Thr Gly Ile Ile Ala Ser Ile Ser Asn 
    210                 215                 220                 


Asp Asn Pro Ala Leu Ile Ser Cys Val Asp Asp Glu Arg Leu Glu Phe 
225                 230                 235                 240 


Gln Asp Gly Asp Leu Val Val Phe Ser Glu Val His Gly Met Thr Glu 
                245                 250                 255     


Leu Asn Asp Gly Lys Pro Arg Lys Val Lys Asn Ala Arg Pro Phe Ser 
            260                 265                 270         


Phe Ser Ile Glu Glu Asp Thr Ser Asn Phe Gly Ile Tyr Val Lys Gly 
        275                 280                 285             


Gly Ile Val Thr Gln Val Lys Glu Pro Lys Val Leu Cys Phe Lys Ala 
    290                 295                 300                 


Leu Arg Asp Ala Met Thr Asp Pro Gly Glu Val Leu Leu Ser Asp Phe 
305                 310                 315                 320 


Ser Lys Phe Glu Arg Pro Pro Val Leu His Leu Ala Phe Gln Ala Leu 
                325                 330                 335     


Asp Lys Phe Lys Lys Asp His Gly Arg Cys Pro Ala Ala Gly Cys Glu 
            340                 345                 350         


Glu Asp Ala His Ser Phe Leu Lys Ile Ala Ala Ala Ile Asn Glu Ala 
        355                 360                 365             


Ser Ala Asp Arg Lys Leu Asp Thr Ile Asp Glu Lys Leu Phe Arg Gln 
    370                 375                 380                 


Phe Ala Ser Gly Ser Arg Ala Val Leu Asn Pro Met Ala Ala Met Phe 
385                 390                 395                 400 


Gly Gly Ile Val Gly Gln Glu Val Val Lys Ala Cys Ser Gly Lys Phe 
                405                 410                 415     


His Pro Leu Asn Gln Phe Phe Tyr Phe Asp Ser Val Glu Ser Leu Pro 
            420                 425                 430         


Thr Tyr Pro Leu Glu Pro Gln Asp Leu Lys Pro Ser Asn Asn Arg Tyr 
        435                 440                 445             


Asp Ala Gln Val Ser Val Phe Gly Ser Lys Leu Gln Lys Lys Met Glu 
    450                 455                 460                 


Glu Ala Asn Thr Phe Val Val Gly Ser Gly Ala Leu Gly Cys Glu Phe 
465                 470                 475                 480 


Leu Lys Asn Leu Ala Leu Met Gly Val Ser Cys Ser Ser Lys Gly Lys 
                485                 490                 495     


Leu Thr Ile Thr Asp Asp Asp Ile Ile Glu Lys Ser Asn Leu Ser Arg 
            500                 505                 510         


Gln Phe Leu Phe Arg Asp Trp Asn Ile Gly Gln Ala Lys Ser Thr Val 
        515                 520                 525             


Ala Ala Thr Ala Ala Ser Ala Ile Asn Pro Ser Leu His Ile Asp Ala 
    530                 535                 540                 


Leu Gln Asn Arg Ala Cys Pro Asp Thr Glu Asn Val Phe His Asp Thr 
545                 550                 555                 560 


Phe Trp Glu Gly Leu Asp Val Val Ile Asn Ala Leu Asp Asn Val Asn 
                565                 570                 575     


Ala Arg Met Tyr Met Asp Met Arg Cys Leu Tyr Phe Gln Lys Pro Leu 
            580                 585                 590         


Leu Glu Ser Gly Thr Leu Gly Ala Lys Cys Asn Ile Gln Met Val Ile 
        595                 600                 605             


Pro His Leu Thr Glu Asn Tyr Gly Ala Ser Arg Asp Pro Pro Glu Lys 
    610                 615                 620                 


Gln Ala Pro Met Cys Thr Val His Ser Phe Pro His Asn Ile Asp His 
625                 630                 635                 640 


Cys Leu Thr Trp Ala Arg Ser Glu Phe Glu Gly Leu Leu Glu Lys Thr 
                645                 650                 655     


Pro Asn Glu Val Asn Ser Phe Leu Ser Asn Pro Ala Gln Tyr Ala Ala 
            660                 665                 670         


Ala Met Arg Lys Ala Gly Asp Ala Gln Ala Arg Glu Leu Leu Glu Arg 
        675                 680                 685             


Val Ser Glu Cys Leu Asn Lys Asp Arg Cys Ser Thr Phe Asp Asp Cys 
    690                 695                 700                 


Ile Ser Trp Ala Arg Leu Lys Phe Glu Asp Tyr Phe Ser Asn Arg Val 
705                 710                 715                 720 


Lys Gln Leu Thr Phe Thr Phe Pro Glu Asp Ala Ala Thr Ser Met Gly 
                725                 730                 735     


Ala Pro Phe Trp Ser Ala Pro Lys Arg Phe Pro Arg Ala Leu Gln Phe 
            740                 745                 750         


Ser Ala Ala Asp Gln Ser His Leu Asn Phe Ile Met Ser Ala Ser Ile 
        755                 760                 765             


Leu Arg Ala Glu Ser Phe Gly Val Ala Ile Pro Glu Trp Ala Lys Asp 
    770                 775                 780                 


Thr Ser Lys Leu Ala Asp Val Val Asn Lys Ile Ala Val Pro Thr Phe 
785                 790                 795                 800 


Glu Pro Lys Gln Gly Val Asn Ile Val Thr Asp Glu Lys Ala Ser Asn 
                805                 810                 815     


Leu Ser Ser Thr Ser Val Asp Asp Val Ala Val Ile Glu Asp Leu Leu 
            820                 825                 830         


Ala Lys Leu Gln Glu Tyr Ala Lys Met Leu Leu Pro Gly Phe Gln Met 
        835                 840                 845             


Lys Pro Ile Gln Phe Glu Lys Asp Asp Asp Thr Asn Phe His Met Asp 
    850                 855                 860                 


Leu Ile Ser Gly Leu Ala Asn Met Arg Ala Arg Asn Tyr Ser Ile Pro 
865                 870                 875                 880 


Glu Val Asp Lys Leu Lys Ala Lys Phe Ile Ala Gly Arg Ile Ile Pro 
                885                 890                 895     


Ala Ile Ala Thr Ser Thr Ala Met Ala Thr Gly Leu Val Cys Leu Glu 
            900                 905                 910         


Leu Tyr Lys Val Ile Ala Gly Glu His Pro Val Glu Asp Tyr Arg Asn 
        915                 920                 925             


Thr Phe Ala Asn Leu Ala Leu Pro Leu Phe Ser Met Ala Glu Pro Val 
    930                 935                 940                 


Pro Pro Lys Val Met Lys His Lys Glu Thr Ser Trp Thr Val Trp Asp 
945                 950                 955                 960 


Arg Trp Ser Val Gln Gly Asn Leu Thr Leu Ala Glu Leu Leu Gln Trp 
                965                 970                 975     


Phe Ala Asp Lys Gly Leu Thr Ala Tyr Ser Ile Ser Cys Gly Thr Ser 
            980                 985                 990         


Leu Leu Tyr Asn Asn Met Phe Ala  Arg His Lys Asp Arg  Leu Thr Lys 
        995                 1000                 1005             


Lys Val  Val Asp Ile Ala Arg  Glu Val Ala Lys Val  Asp Val Pro 
    1010                 1015                 1020             


Glu Tyr  Arg Arg His Leu Asp  Ile Gly Val Ala Cys  Glu Asp Glu 
    1025                 1030                 1035             


Asp Glu  Asn Asp Val Asp Ile  Pro Leu Val Ser Val  Tyr Phe Arg 
    1040                 1045                 1050             


<210>  11
<211>  1058
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Ser Ser Pro Leu Ser Lys Lys Arg Arg Val Ser Gly Pro Asp 
1               5                   10                  15      


Pro Lys Pro Gly Ser Asn Cys Ser Pro Ala Gln Ser Val Leu Ser Glu 
            20                  25                  30          


Val Pro Ser Val Pro Thr Asn Gly Met Ala Lys Asn Gly Ser Glu Ala 
        35                  40                  45              


Asp Ile Asp Glu Gly Leu Tyr Ser Arg Gln Leu Tyr Val Leu Gly His 
    50                  55                  60                  


Glu Ala Met Lys Arg Leu Gln Thr Ser Ser Val Leu Val Ser Gly Leu 
65                  70                  75                  80  


Arg Gly Leu Gly Val Glu Ile Ala Lys Asn Ile Ile Leu Gly Gly Val 
                85                  90                  95      


Lys Ala Val Thr Leu His Asp Gln Gly Thr Ala Gln Trp Ala Asp Leu 
            100                 105                 110         


Ser Ser Gln Phe Tyr Leu Arg Glu Glu Asp Ile Gly Lys Asn Arg Ala 
        115                 120                 125             


Glu Val Ser Gln Pro Arg Leu Ala Glu Leu Asn Ser Tyr Val Pro Val 
    130                 135                 140                 


Thr Ala Tyr Thr Gly Pro Leu Val Glu Asp Phe Leu Ser Gly Phe Gln 
145                 150                 155                 160 


Val Val Val Leu Thr Asn Thr Pro Leu Glu Asp Gln Leu Arg Val Gly 
                165                 170                 175     


Glu Phe Cys His Asn Arg Gly Ile Lys Leu Val Val Ala Asp Thr Arg 
            180                 185                 190         


Gly Leu Phe Gly Gln Leu Phe Cys Asp Phe Gly Glu Glu Met Ile Leu 
        195                 200                 205             


Thr Asp Ser Asn Gly Glu Gln Pro Leu Ser Ala Met Val Ser Met Val 
    210                 215                 220                 


Thr Lys Asp Asn Pro Gly Val Val Thr Cys Leu Asp Glu Ala Arg His 
225                 230                 235                 240 


Gly Phe Glu Ser Gly Asp Phe Val Ser Phe Ser Glu Val Gln Gly Met 
                245                 250                 255     


Val Glu Leu Asn Gly Asn Gln Pro Met Glu Ile Lys Val Leu Gly Pro 
            260                 265                 270         


Tyr Thr Phe Ser Ile Cys Asp Thr Ser Asn Phe Ser Asp Tyr Ile Arg 
        275                 280                 285             


Gly Gly Ile Val Ser Gln Val Lys Val Pro Lys Lys Ile Ser Phe Lys 
    290                 295                 300                 


Ser Leu Val Ala Ser Leu Ala Glu Pro Asp Phe Val Val Thr Asp Phe 
305                 310                 315                 320 


Ala Lys Phe Ser Arg Pro Ala Gln Leu His Ile Gly Phe Gln Ala Leu 
                325                 330                 335     


His Gln Phe Cys Ala Gln His Gly Arg Pro Pro Arg Pro Arg Asn Glu 
            340                 345                 350         


Glu Asp Ala Ala Glu Leu Val Ala Leu Ala Gln Ala Val Asn Ala Arg 
        355                 360                 365             


Ala Leu Pro Ala Val Gln Gln Asn Asn Leu Asp Glu Asp Leu Ile Arg 
    370                 375                 380                 


Lys Leu Ala Tyr Val Ala Ala Gly Asp Leu Ala Pro Ile Asn Ala Phe 
385                 390                 395                 400 


Ile Gly Gly Leu Ala Ala Gln Glu Val Met Lys Ala Cys Ser Gly Lys 
                405                 410                 415     


Phe Met Pro Ile Met Gln Trp Leu Tyr Phe Asp Ala Leu Glu Cys Leu 
            420                 425                 430         


Pro Glu Asp Lys Glu Val Leu Thr Glu Asp Lys Cys Leu Gln Arg Gln 
        435                 440                 445             


Asn Arg Tyr Asp Gly Gln Val Ala Val Phe Gly Ser Asp Leu Gln Glu 
    450                 455                 460                 


Lys Leu Gly Lys Gln Lys Tyr Phe Leu Val Gly Ala Gly Ala Ile Gly 
465                 470                 475                 480 


Cys Glu Leu Leu Lys Asn Phe Ala Met Ile Gly Leu Gly Cys Gly Glu 
                485                 490                 495     


Gly Gly Glu Ile Ile Val Thr Asp Met Asp Thr Ile Glu Lys Ser Asn 
            500                 505                 510         


Leu Asn Arg Gln Phe Leu Phe Arg Pro Trp Asp Val Thr Lys Leu Lys 
        515                 520                 525             


Ser Asp Thr Ala Ala Ala Ala Val Arg Gln Met Asn Pro His Ile Arg 
    530                 535                 540                 


Val Thr Ser His Gln Asn Arg Val Gly Pro Asp Thr Glu Arg Ile Tyr 
545                 550                 555                 560 


Asp Asp Asp Phe Phe Gln Asn Leu Asp Gly Val Ala Asn Ala Leu Asp 
                565                 570                 575     


Asn Val Asp Ala Arg Met Tyr Met Asp Arg Arg Cys Val Tyr Tyr Arg 
            580                 585                 590         


Lys Pro Leu Leu Glu Ser Gly Thr Leu Gly Thr Lys Gly Asn Val Gln 
        595                 600                 605             


Val Val Ile Pro Phe Leu Thr Glu Ser Tyr Ser Ser Ser Gln Asp Pro 
    610                 615                 620                 


Pro Glu Lys Ser Ile Pro Ile Cys Thr Leu Lys Asn Phe Pro Asn Ala 
625                 630                 635                 640 


Ile Glu His Thr Leu Gln Trp Ala Arg Asp Glu Phe Glu Gly Leu Phe 
                645                 650                 655     


Lys Gln Pro Ala Glu Asn Val Asn Gln Tyr Leu Thr Asp Pro Lys Phe 
            660                 665                 670         


Val Glu Arg Thr Leu Arg Leu Ala Gly Thr Gln Pro Leu Glu Val Leu 
        675                 680                 685             


Glu Ala Val Gln Arg Ser Leu Val Leu Gln Arg Pro Gln Thr Trp Ala 
    690                 695                 700                 


Asp Cys Val Thr Trp Ala Cys His His Trp His Thr Gln Tyr Ser Asn 
705                 710                 715                 720 


Asn Ile Arg Gln Leu Leu His Asn Phe Pro Pro Asp Gln Leu Thr Ser 
                725                 730                 735     


Ser Gly Ala Pro Phe Trp Ser Gly Pro Lys Arg Cys Pro His Pro Leu 
            740                 745                 750         


Thr Phe Asp Val Asn Asn Pro Leu His Leu Asp Tyr Val Met Ala Ala 
        755                 760                 765             


Ala Asn Leu Phe Ala Gln Thr Tyr Gly Leu Thr Gly Ser Gln Asp Arg 
    770                 775                 780                 


Ala Ala Val Ala Thr Phe Leu Gln Ser Val Gln Val Pro Glu Phe Thr 
785                 790                 795                 800 


Pro Lys Ser Gly Val Lys Ile His Val Ser Asp Gln Glu Leu Gln Ser 
                805                 810                 815     


Ala Asn Ala Ser Val Asp Asp Ser Arg Leu Glu Glu Leu Lys Ala Thr 
            820                 825                 830         


Leu Pro Ser Pro Asp Lys Leu Pro Gly Phe Lys Met Tyr Pro Ile Asp 
        835                 840                 845             


Phe Glu Lys Asp Asp Asp Ser Asn Phe His Met Asp Phe Ile Val Ala 
    850                 855                 860                 


Ala Ser Asn Leu Arg Ala Glu Asn Tyr Asp Ile Pro Ser Ala Asp Arg 
865                 870                 875                 880 


His Lys Ser Lys Leu Ile Ala Gly Lys Ile Ile Pro Ala Ile Ala Thr 
                885                 890                 895     


Thr Thr Ala Ala Val Val Gly Leu Val Cys Leu Glu Leu Tyr Lys Val 
            900                 905                 910         


Val Gln Gly His Arg Gln Leu Asp Ser Tyr Lys Asn Gly Phe Leu Asn 
        915                 920                 925             


Leu Ala Leu Pro Phe Phe Gly Phe Ser Glu Pro Leu Ala Ala Pro Arg 
    930                 935                 940                 


His Gln Tyr Tyr Asn Gln Glu Trp Thr Leu Trp Asp Arg Phe Glu Val 
945                 950                 955                 960 


Gln Gly Leu Gln Pro Asn Gly Glu Glu Met Thr Leu Lys Gln Phe Leu 
                965                 970                 975     


Asp Tyr Phe Lys Thr Glu His Lys Leu Glu Ile Thr Met Leu Ser Gln 
            980                 985                 990         


Gly Val Ser Met Leu Tyr Ser Phe  Phe Met Pro Ala Ala  Lys Leu Lys 
        995                 1000                 1005             


Glu Arg  Leu Asp Gln Pro Met  Thr Glu Ile Val Ser  Arg Val Ser 
    1010                 1015                 1020             


Lys Arg  Lys Leu Gly Arg His  Val Arg Ala Leu Val  Leu Glu Leu 
    1025                 1030                 1035             


Cys Cys  Asn Asp Glu Ser Gly  Glu Asp Val Glu Val  Pro Tyr Val 
    1040                 1045                 1050             


Arg Tyr  Thr Ile Arg 
    1055             


<210>  12
<211>  1058
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  12

Met Ser Ser Ser Pro Leu Ser Lys Lys Arg Arg Val Ser Gly Pro Asp 
1               5                   10                  15      


Pro Lys Pro Gly Ser Asn Cys Ser Pro Ala Gln Ser Val Leu Pro Gln 
            20                  25                  30          


Val Pro Ser Ala Pro Thr Asn Gly Met Ala Lys Asn Gly Ser Glu Ala 
        35                  40                  45              


Asp Ile Asp Glu Gly Leu Tyr Ser Arg Gln Leu Tyr Val Leu Gly His 
    50                  55                  60                  


Glu Ala Met Lys Arg Leu Gln Thr Ser Ser Val Leu Val Ser Gly Leu 
65                  70                  75                  80  


Arg Gly Leu Gly Val Glu Ile Ala Lys Asn Ile Ile Leu Gly Gly Val 
                85                  90                  95      


Lys Ala Val Thr Leu His Asp Gln Gly Thr Ala Gln Trp Ala Asp Leu 
            100                 105                 110         


Ser Ser Gln Phe Tyr Leu Arg Glu Glu Asp Ile Gly Lys Asn Arg Ala 
        115                 120                 125             


Glu Val Ser Gln Pro Arg Leu Ala Glu Leu Asn Ser Tyr Val Pro Val 
    130                 135                 140                 


Thr Ala Tyr Thr Gly Pro Leu Val Glu Asp Phe Leu Ser Gly Phe Gln 
145                 150                 155                 160 


Val Val Val Leu Thr Asn Ser Pro Leu Glu Asp Gln Leu Arg Val Gly 
                165                 170                 175     


Glu Phe Cys His Ser Arg Gly Ile Lys Leu Val Val Ala Asp Thr Arg 
            180                 185                 190         


Gly Leu Phe Gly Gln Leu Phe Cys Asp Phe Gly Glu Glu Met Ile Leu 
        195                 200                 205             


Thr Asp Ser Asn Gly Glu Gln Pro Leu Ser Thr Met Val Ser Met Val 
    210                 215                 220                 


Thr Lys Asp Asn Pro Gly Val Val Thr Cys Leu Asp Glu Ala Arg His 
225                 230                 235                 240 


Gly Phe Glu Ser Gly Asp Phe Val Ser Phe Ser Glu Val Gln Gly Met 
                245                 250                 255     


Thr Glu Leu Asn Gly Asn Gln Pro Ile Glu Ile Lys Val Leu Gly Pro 
            260                 265                 270         


Tyr Thr Phe Ser Ile Cys Asp Thr Ser Asn Phe Ser Asp Tyr Ile Arg 
        275                 280                 285             


Gly Gly Ile Val Ser Gln Val Lys Val Pro Lys Lys Ile Ser Phe Lys 
    290                 295                 300                 


Ser Leu Ser Ala Ser Leu Ala Glu Pro Asp Phe Val Met Thr Asp Phe 
305                 310                 315                 320 


Ala Lys Phe Ser Arg Pro Ala Gln Leu His Ile Gly Phe Gln Ala Leu 
                325                 330                 335     


His Lys Phe Cys Ala Gln His Ser Arg Pro Pro Arg Pro Arg Asn Glu 
            340                 345                 350         


Glu Asp Ala Ala Glu Leu Val Thr Leu Ala Arg Ala Val Asn Ser Lys 
        355                 360                 365             


Ala Ser Ser Ala Val Gln Gln Asp Ser Leu Asp Glu Asp Leu Ile Arg 
    370                 375                 380                 


Asn Leu Ala Phe Val Ala Ala Gly Asp Leu Ala Pro Ile Asn Ala Phe 
385                 390                 395                 400 


Ile Gly Gly Leu Ala Ala Gln Glu Val Met Lys Ala Cys Ser Gly Lys 
                405                 410                 415     


Phe Met Pro Ile Met Gln Trp Leu Tyr Phe Asp Ala Leu Glu Cys Leu 
            420                 425                 430         


Pro Glu Asp Lys Glu Ser Leu Thr Glu Asp Lys Cys Leu Pro Arg Gln 
        435                 440                 445             


Asn Arg Tyr Asp Gly Gln Val Ala Val Phe Gly Ser Asp Leu Gln Glu 
    450                 455                 460                 


Lys Leu Gly Arg Gln Lys Tyr Phe Leu Val Gly Ala Gly Ala Ile Gly 
465                 470                 475                 480 


Cys Glu Leu Leu Lys Asn Phe Ala Met Ile Gly Leu Gly Cys Gly Glu 
                485                 490                 495     


Asn Gly Glu Ile Ile Val Thr Asp Met Asp Thr Ile Glu Lys Ser Asn 
            500                 505                 510         


Leu Asn Arg Gln Phe Leu Phe Arg Pro Trp Asp Val Thr Lys Leu Lys 
        515                 520                 525             


Ser Asp Thr Ala Ala Ala Ala Val His Gln Met Asn Pro His Ile Arg 
    530                 535                 540                 


Val Thr Ser His Gln Asn Arg Val Gly Pro Asp Thr Glu Arg Ile Tyr 
545                 550                 555                 560 


Asp Asp Asp Phe Phe Gln Thr Leu Asp Gly Val Ala Asn Ala Leu Asp 
                565                 570                 575     


Asn Val Asp Ala Arg Met Tyr Met Asp Arg Arg Cys Val Tyr Tyr Arg 
            580                 585                 590         


Lys Pro Leu Leu Glu Ser Gly Thr Leu Gly Thr Lys Gly Asn Val Gln 
        595                 600                 605             


Val Val Ile Pro Phe Leu Thr Glu Ser Tyr Ser Ser Ser Gln Asp Pro 
    610                 615                 620                 


Pro Glu Lys Ser Ile Pro Ile Cys Thr Leu Lys Asn Phe Pro Asn Ala 
625                 630                 635                 640 


Ile Glu His Thr Leu Gln Trp Ala Arg Asp Glu Phe Glu Gly Leu Phe 
                645                 650                 655     


Lys Gln Pro Ala Glu Asn Val Asn Gln Tyr Leu Thr Asp Pro Lys Phe 
            660                 665                 670         


Val Glu Arg Thr Leu Arg Leu Ala Gly Thr Gln Pro Leu Glu Val Leu 
        675                 680                 685             


Glu Ala Val Gln Arg Ser Leu Val Leu Gln Leu Pro Gln Ser Trp Ala 
    690                 695                 700                 


Asp Cys Val Thr Trp Ala Cys His His Trp His Thr Gln Tyr Ser Asn 
705                 710                 715                 720 


Asn Ile Arg Gln Leu Leu His Asn Phe Pro Pro Asp Gln Leu Thr Ser 
                725                 730                 735     


Ser Gly Ala Pro Phe Trp Ser Gly Pro Lys Arg Cys Pro His Pro Leu 
            740                 745                 750         


Thr Phe Asp Val Ser Asn Pro Leu His Leu Asp Tyr Val Met Ala Ala 
        755                 760                 765             


Ala Asn Leu Phe Ala Gln Thr Tyr Gly Leu Ala Gly Ser Gln Asp Arg 
    770                 775                 780                 


Ala Ala Val Ala Thr Leu Leu Gln Ser Val Gln Val Pro Glu Phe Thr 
785                 790                 795                 800 


Pro Lys Ser Gly Val Lys Ile His Val Ser Asp Gln Glu Leu Gln Ser 
                805                 810                 815     


Ala Asn Ala Ser Val Asp Asp Ser Arg Leu Glu Glu Leu Lys Ala Thr 
            820                 825                 830         


Leu Pro Ser Pro Asp Lys Leu Pro Gly Phe Lys Met Tyr Pro Ile Asp 
        835                 840                 845             


Phe Glu Lys Asp Asp Asp Ser Asn Phe His Met Asp Phe Ile Val Ala 
    850                 855                 860                 


Ala Ser Asn Leu Arg Ala Glu Asn Tyr Asp Ile Pro Pro Ala Asp Arg 
865                 870                 875                 880 


His Lys Ser Lys Leu Ile Ala Gly Lys Ile Ile Pro Ala Ile Ala Thr 
                885                 890                 895     


Thr Thr Ala Ala Val Val Gly Leu Val Cys Leu Glu Leu Tyr Lys Val 
            900                 905                 910         


Val Gln Gly His Arg His Leu Asp Ser Tyr Lys Asn Gly Phe Leu Asn 
        915                 920                 925             


Leu Ala Leu Pro Phe Phe Gly Phe Ser Glu Pro Leu Ala Ala Pro Arg 
    930                 935                 940                 


His Gln Tyr Tyr Asn Gln Glu Trp Thr Leu Trp Asp Arg Phe Glu Val 
945                 950                 955                 960 


Gln Gly Leu Gln Pro Asn Gly Glu Glu Met Thr Leu Lys Gln Phe Leu 
                965                 970                 975     


Asp Tyr Phe Lys Thr Glu His Lys Leu Glu Ile Thr Met Leu Ser Gln 
            980                 985                 990         


Gly Val Ser Met Leu Tyr Ser Phe  Phe Met Pro Ala Ala  Lys Leu Lys 
        995                 1000                 1005             


Glu Arg  Leu Asp Gln Pro Met  Thr Glu Ile Val Ser  Arg Val Ser 
    1010                 1015                 1020             


Lys Arg  Lys Leu Gly Arg His  Val Arg Ala Leu Val  Leu Glu Leu 
    1025                 1030                 1035             


Cys Cys  Asn Asp Glu Ser Gly  Glu Asp Val Glu Val  Pro Tyr Val 
    1040                 1045                 1050             


Arg Tyr  Thr Ile Arg 
    1055             


<210>  13
<211>  1058
<212>  PRT
<213>  Bos taurus

<400>  13

Met Ser Ser Ser Pro Leu Ser Lys Lys Arg Arg Val Ser Gly Pro Asp 
1               5                   10                  15      


Pro Lys Pro Gly Ser Asn Cys Ser Pro Ala His Ser Val Leu Ser Glu 
            20                  25                  30          


Val Pro Ser Val Pro Ala Asn Gly Met Ala Lys Asn Val Ser Asp Ala 
        35                  40                  45              


Asp Ile Asp Glu Gly Leu Tyr Ser Arg Gln Leu Tyr Val Leu Gly His 
    50                  55                  60                  


Glu Ala Met Lys Arg Leu Gln Thr Ser Ser Val Leu Val Ser Gly Leu 
65                  70                  75                  80  


Arg Gly Leu Gly Val Glu Ile Ala Lys Asn Ile Ile Leu Gly Gly Val 
                85                  90                  95      


Lys Ala Val Thr Leu His Asp Gln Gly Thr Ala Gln Trp Ala Asp Leu 
            100                 105                 110         


Ser Ser Gln Phe Tyr Leu Arg Glu Glu Asp Ile Gly Lys Asn Arg Ala 
        115                 120                 125             


Glu Val Ser Gln Pro Arg Leu Ala Glu Leu Asn Ser Tyr Val Pro Val 
    130                 135                 140                 


Ser Ala Tyr Thr Gly Pro Leu Val Glu Asp Phe Leu Ser Asp Phe Gln 
145                 150                 155                 160 


Val Val Val Leu Thr Asn Ser Pro Leu Glu Asp Gln Leu Arg Val Gly 
                165                 170                 175     


Glu Phe Cys His Ser His Gly Ile Lys Leu Val Val Ala Asp Thr Arg 
            180                 185                 190         


Gly Leu Phe Gly Gln Leu Phe Cys Asp Phe Gly Glu Glu Met Ile Leu 
        195                 200                 205             


Thr Asp Ser Asn Gly Glu Gln Pro Leu Ser Ala Met Val Ser Met Val 
    210                 215                 220                 


Thr Lys Asp Asn Pro Gly Val Val Thr Cys Leu Asp Glu Ala Arg His 
225                 230                 235                 240 


Gly Phe Glu Ser Gly Asp Phe Val Ser Phe Ser Glu Val Gln Gly Met 
                245                 250                 255     


Ile Glu Leu Asn Gly Ser Gln Pro Met Glu Ile Lys Val Leu Gly Pro 
            260                 265                 270         


Tyr Thr Phe Ser Ile Cys Asp Thr Ser Asn Phe Ser Asp Tyr Ile Arg 
        275                 280                 285             


Gly Gly Ile Val Ser Gln Val Lys Val Pro Lys Lys Ile Ser Phe Lys 
    290                 295                 300                 


Ser Leu Pro Ala Ser Leu Ala Glu Pro Asp Phe Val Met Thr Asp Phe 
305                 310                 315                 320 


Ala Lys Tyr Ser Arg Pro Ala Gln Leu His Ile Gly Phe Gln Ala Leu 
                325                 330                 335     


His His Phe Cys Ala Gln His Gly Arg Ser Pro Arg Pro His Asn Glu 
            340                 345                 350         


Glu Asp Ala Ala Glu Leu Val Thr Ile Ala Gln Ala Val Asn Ala Arg 
        355                 360                 365             


Ser Leu Pro Ala Val Gln Gln Gly Ser Leu Asp Glu Asp Leu Ile Arg 
    370                 375                 380                 


Lys Leu Ala Tyr Val Ala Ala Gly Asp Leu Ala Pro Ile Asn Ala Phe 
385                 390                 395                 400 


Ile Gly Gly Leu Ala Ala Gln Glu Val Met Lys Ala Cys Ser Gly Lys 
                405                 410                 415     


Phe Met Pro Ile Met Gln Trp Leu Tyr Phe Asp Ala Leu Glu Cys Leu 
            420                 425                 430         


Pro Glu Asp Lys Glu Ala Leu Thr Glu Asp Lys Cys Leu Pro Arg Gln 
        435                 440                 445             


Asn Arg Tyr Asp Gly Gln Val Ala Val Phe Gly Ser Asp Leu Gln Glu 
    450                 455                 460                 


Arg Leu Gly Lys Gln Lys Tyr Phe Leu Val Gly Ala Gly Ala Ile Gly 
465                 470                 475                 480 


Cys Glu Leu Leu Lys Asn Phe Ala Met Ile Gly Leu Gly Cys Ala Glu 
                485                 490                 495     


Asp Gly Glu Ile Val Val Thr Asp Met Asp Thr Ile Glu Lys Ser Asn 
            500                 505                 510         


Leu Asn Arg Gln Phe Leu Phe Arg Pro Trp Asp Val Thr Lys Leu Lys 
        515                 520                 525             


Ser Asp Thr Ala Ala Ala Ala Val Arg Gln Met Asn Pro His Ile Arg 
    530                 535                 540                 


Val Thr Ser His Gln Asn Arg Val Gly Pro Asp Thr Glu Arg Ile Tyr 
545                 550                 555                 560 


Asp Asp Asp Phe Phe Gln Asn Leu Asp Gly Val Thr Asn Ala Leu Asp 
                565                 570                 575     


Asn Val Asp Ala Arg Met Tyr Met Asp Arg Arg Cys Val Tyr Tyr Arg 
            580                 585                 590         


Lys Pro Leu Leu Glu Ser Gly Thr Leu Gly Thr Lys Gly Asn Val Gln 
        595                 600                 605             


Val Val Ile Pro Phe Leu Thr Glu Ser Tyr Ser Ser Ser Gln Asp Pro 
    610                 615                 620                 


Pro Glu Lys Ser Ile Pro Ile Cys Thr Leu Lys Asn Phe Pro Asn Ala 
625                 630                 635                 640 


Ile Glu His Thr Leu Gln Trp Ala Arg Asp Glu Phe Glu Gly Leu Phe 
                645                 650                 655     


Lys Gln Pro Ala Glu Asn Val Asn Gln Tyr Leu Thr Asp Pro Lys Phe 
            660                 665                 670         


Val Glu Arg Thr Leu Arg Leu Ala Gly Thr Gln Pro Leu Glu Val Leu 
        675                 680                 685             


Glu Ala Val Gln Arg Ser Leu Val Leu Gln Arg Pro Gln Thr Trp Ala 
    690                 695                 700                 


Asp Cys Val Thr Trp Ala Cys His His Trp His Thr Gln Tyr Ser Asn 
705                 710                 715                 720 


Asn Ile Arg Gln Leu Leu His Asn Phe Pro Pro Asp Gln Leu Thr Ser 
                725                 730                 735     


Ser Gly Ala Pro Phe Trp Ser Gly Pro Lys Arg Cys Pro His Pro Leu 
            740                 745                 750         


Thr Phe Asp Val Ser Asn Pro Leu His Leu Asp Tyr Val Ile Ala Ala 
        755                 760                 765             


Ala Asn Leu Phe Ala Gln Thr Tyr Gly Leu Thr Gly Ser Gln Asp Arg 
    770                 775                 780                 


Ala Ala Val Ala Thr Leu Leu Gln Ser Val Gln Val Pro Glu Phe Thr 
785                 790                 795                 800 


Pro Lys Ser Gly Val Lys Ile His Val Ser Asp Gln Glu Leu Gln Ser 
                805                 810                 815     


Ala Asn Ala Ser Val Asp Asp Ser Arg Leu Glu Glu Leu Lys Ala Thr 
            820                 825                 830         


Leu Pro Ser Pro Glu Lys Leu Pro Gly Phe Lys Met Tyr Pro Ile Asp 
        835                 840                 845             


Phe Glu Lys Asp Asp Asp Thr Asn Phe His Met Asp Phe Ile Val Ala 
    850                 855                 860                 


Ala Ser Asn Leu Arg Ala Glu Asn Tyr Asp Ile Pro Pro Ala Asp Arg 
865                 870                 875                 880 


His Lys Ser Lys Leu Ile Ala Gly Lys Ile Ile Pro Ala Ile Ala Thr 
                885                 890                 895     


Thr Thr Ala Ala Val Val Gly Leu Val Cys Leu Glu Leu Tyr Lys Val 
            900                 905                 910         


Val Gln Gly His Arg Gln Leu Asn Ser Tyr Lys Asn Gly Phe Leu Asn 
        915                 920                 925             


Leu Ala Leu Pro Phe Phe Gly Phe Ser Glu Pro Leu Ala Ala Pro Arg 
    930                 935                 940                 


His Gln Tyr Tyr Asn Gln Glu Trp Thr Leu Trp Asp Arg Phe Glu Val 
945                 950                 955                 960 


Gln Gly Leu Gln Pro Asn Gly Glu Glu Met Thr Leu Lys Gln Phe Leu 
                965                 970                 975     


Asp Tyr Phe Lys Thr Glu His Lys Leu Glu Ile Thr Met Leu Ser Gln 
            980                 985                 990         


Gly Val Ser Met Leu Tyr Ser Phe  Phe Met Pro Ala Ala  Lys Leu Lys 
        995                 1000                 1005             


Glu Arg  Leu Asp Gln Pro Met  Thr Glu Ile Val Ser  Arg Val Ser 
    1010                 1015                 1020             


Lys Arg  Lys Leu Gly Arg His  Val Arg Ala Leu Val  Leu Glu Leu 
    1025                 1030                 1035             


Cys Cys  Asn Asp Glu Ser Gly  Glu Asp Val Glu Val  Pro Tyr Val 
    1040                 1045                 1050             


Arg Tyr  Thr Ile Arg 
    1055             


<210>  14
<211>  1024
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  14

Met Ser Ser Asn Asn Ser Gly Leu Ser Ala Ala Gly Glu Ile Asp Glu 
1               5                   10                  15      


Ser Leu Tyr Ser Arg Gln Leu Tyr Val Leu Gly Lys Glu Ala Met Leu 
            20                  25                  30          


Lys Met Gln Thr Ser Asn Val Leu Ile Leu Gly Leu Lys Gly Leu Gly 
        35                  40                  45              


Val Glu Ile Ala Lys Asn Val Val Leu Ala Gly Val Lys Ser Met Thr 
    50                  55                  60                  


Val Phe Asp Pro Glu Pro Val Gln Leu Ala Asp Leu Ser Thr Gln Phe 
65                  70                  75                  80  


Phe Leu Thr Glu Lys Asp Ile Gly Gln Lys Arg Gly Asp Val Thr Arg 
                85                  90                  95      


Ala Lys Leu Ala Glu Leu Asn Ala Tyr Val Pro Val Asn Val Leu Asp 
            100                 105                 110         


Ser Leu Asp Asp Val Thr Gln Leu Ser Gln Phe Gln Val Val Val Ala 
        115                 120                 125             


Thr Asp Thr Val Ser Leu Glu Asp Lys Val Lys Ile Asn Glu Phe Cys 
    130                 135                 140                 


His Ser Ser Gly Ile Arg Phe Ile Ser Ser Glu Thr Arg Gly Leu Phe 
145                 150                 155                 160 


Gly Asn Thr Phe Val Asp Leu Gly Asp Glu Phe Thr Val Leu Asp Pro 
                165                 170                 175     


Thr Gly Glu Glu Pro Arg Thr Gly Met Val Ser Asp Ile Glu Pro Asp 
            180                 185                 190         


Gly Thr Val Thr Met Leu Asp Asp Asn Arg His Gly Leu Glu Asp Gly 
        195                 200                 205             


Asn Phe Val Arg Phe Ser Glu Val Glu Gly Leu Asp Lys Leu Asn Asp 
    210                 215                 220                 


Gly Thr Leu Phe Lys Val Glu Val Leu Gly Pro Phe Ala Phe Arg Ile 
225                 230                 235                 240 


Gly Ser Val Lys Glu Tyr Gly Glu Tyr Lys Lys Gly Gly Ile Phe Thr 
                245                 250                 255     


Glu Val Lys Val Pro Arg Lys Ile Ser Phe Lys Ser Leu Lys Gln Gln 
            260                 265                 270         


Leu Ser Asn Pro Glu Phe Val Phe Ser Asp Phe Ala Lys Phe Asp Arg 
        275                 280                 285             


Ala Ala Gln Leu His Leu Gly Phe Gln Ala Leu His Gln Phe Ala Val 
    290                 295                 300                 


Arg His Asn Gly Glu Leu Pro Arg Thr Met Asn Asp Glu Asp Ala Asn 
305                 310                 315                 320 


Glu Leu Ile Lys Leu Val Thr Asp Leu Ser Val Gln Gln Pro Glu Val 
                325                 330                 335     


Leu Gly Glu Gly Val Asp Val Asn Glu Asp Leu Ile Lys Glu Leu Ser 
            340                 345                 350         


Tyr Gln Ala Arg Gly Asp Ile Pro Gly Val Val Ala Phe Phe Gly Gly 
        355                 360                 365             


Leu Val Ala Gln Glu Val Leu Lys Ala Cys Ser Gly Lys Phe Thr Pro 
    370                 375                 380                 


Leu Lys Gln Phe Met Tyr Phe Asp Ser Leu Glu Ser Leu Pro Asp Pro 
385                 390                 395                 400 


Lys Asn Phe Pro Arg Asn Glu Lys Thr Thr Gln Pro Val Asn Ser Arg 
                405                 410                 415     


Tyr Asp Asn Gln Ile Ala Val Phe Gly Leu Asp Phe Gln Lys Lys Ile 
            420                 425                 430         


Ala Asn Ser Lys Val Phe Leu Val Gly Ser Gly Ala Ile Gly Cys Glu 
        435                 440                 445             


Met Leu Lys Asn Trp Ala Leu Leu Gly Leu Gly Ser Gly Ser Asp Gly 
    450                 455                 460                 


Tyr Ile Val Val Thr Asp Asn Asp Ser Ile Glu Lys Ser Asn Leu Asn 
465                 470                 475                 480 


Arg Gln Phe Leu Phe Arg Pro Lys Asp Val Gly Lys Asn Lys Ser Glu 
                485                 490                 495     


Val Ala Ala Glu Ala Val Cys Ala Met Asn Pro Asp Leu Lys Gly Lys 
            500                 505                 510         


Ile Asn Ala Lys Ile Asp Lys Val Gly Pro Glu Thr Glu Glu Ile Phe 
        515                 520                 525             


Asn Asp Ser Phe Trp Glu Ser Leu Asp Phe Val Thr Asn Ala Leu Asp 
    530                 535                 540                 


Asn Val Asp Ala Arg Thr Tyr Val Asp Arg Arg Cys Val Phe Tyr Arg 
545                 550                 555                 560 


Lys Pro Leu Leu Glu Ser Gly Thr Leu Gly Thr Lys Gly Asn Thr Gln 
                565                 570                 575     


Val Ile Ile Pro Arg Leu Thr Glu Ser Tyr Ser Ser Ser Arg Asp Pro 
            580                 585                 590         


Pro Glu Lys Ser Ile Pro Leu Cys Thr Leu Arg Ser Phe Pro Asn Lys 
        595                 600                 605             


Ile Asp His Thr Ile Ala Trp Ala Lys Ser Leu Phe Gln Gly Tyr Phe 
    610                 615                 620                 


Thr Asp Ser Ala Glu Asn Val Asn Met Tyr Leu Thr Gln Pro Asn Phe 
625                 630                 635                 640 


Val Glu Gln Thr Leu Lys Gln Ser Gly Asp Val Lys Gly Val Leu Glu 
                645                 650                 655     


Ser Ile Ser Asp Ser Leu Ser Ser Lys Pro His Asn Phe Glu Asp Cys 
            660                 665                 670         


Ile Lys Trp Ala Arg Leu Glu Phe Glu Lys Lys Phe Asn His Asp Ile 
        675                 680                 685             


Lys Gln Leu Leu Phe Asn Phe Pro Lys Asp Ala Lys Thr Ser Asn Gly 
    690                 695                 700                 


Glu Pro Phe Trp Ser Gly Ala Lys Arg Ala Pro Thr Pro Leu Glu Phe 
705                 710                 715                 720 


Asp Ile Tyr Asn Asn Asp His Phe His Phe Val Val Ala Gly Ala Ser 
                725                 730                 735     


Leu Arg Ala Tyr Asn Tyr Gly Ile Lys Ser Asp Asp Ser Asn Ser Lys 
            740                 745                 750         


Pro Asn Val Asp Glu Tyr Lys Ser Val Ile Asp His Met Ile Ile Pro 
        755                 760                 765             


Glu Phe Thr Pro Asn Ala Asn Leu Lys Ile Gln Val Asn Asp Asp Asp 
    770                 775                 780                 


Pro Asp Pro Asn Ala Asn Ala Ala Asn Gly Ser Asp Glu Ile Asp Gln 
785                 790                 795                 800 


Leu Val Ser Ser Leu Pro Asp Pro Ser Thr Leu Ala Gly Phe Lys Leu 
                805                 810                 815     


Glu Pro Val Asp Phe Glu Lys Asp Asp Asp Thr Asn His His Ile Glu 
            820                 825                 830         


Phe Ile Thr Ala Cys Ser Asn Cys Arg Ala Gln Asn Tyr Phe Ile Glu 
        835                 840                 845             


Thr Ala Asp Arg Gln Lys Thr Lys Phe Ile Ala Gly Arg Ile Ile Pro 
    850                 855                 860                 


Ala Ile Ala Thr Thr Thr Ser Leu Val Thr Gly Leu Val Asn Leu Glu 
865                 870                 875                 880 


Leu Tyr Lys Leu Ile Asp Asn Lys Thr Asp Ile Glu Gln Tyr Lys Asn 
                885                 890                 895     


Gly Phe Val Asn Leu Ala Leu Pro Phe Phe Gly Phe Ser Glu Pro Ile 
            900                 905                 910         


Ala Ser Pro Lys Gly Glu Tyr Asn Asn Lys Lys Tyr Asp Lys Ile Trp 
        915                 920                 925             


Asp Arg Phe Asp Ile Lys Gly Asp Ile Lys Leu Ser Asp Leu Ile Glu 
    930                 935                 940                 


His Phe Glu Lys Asp Glu Gly Leu Glu Ile Thr Met Leu Ser Tyr Gly 
945                 950                 955                 960 


Val Ser Leu Leu Tyr Ala Ser Phe Phe Pro Pro Lys Lys Leu Lys Glu 
                965                 970                 975     


Arg Leu Asn Leu Pro Ile Thr Gln Leu Val Lys Leu Val Thr Lys Lys 
            980                 985                 990         


Asp Ile Pro Ala His Val Ser Thr  Met Ile Leu Glu Ile  Cys Ala Asp 
        995                 1000                 1005             


Asp Lys  Glu Gly Glu Asp Val  Glu Val Pro Phe Ile  Thr Ile His 
    1010                 1015                 1020             


Leu 
    


<210>  15
<211>  1080
<212>  PRT
<213>  Arabidopsis thaliana

<400>  15

Met Leu His Lys Arg Ala Ser Glu Ala Asn Asp Lys Asn Asp Asn Thr 
1               5                   10                  15      


Ile Ile Gly Ser Asp Leu Ala Ser Ser Lys Lys Arg Arg Ile Asp Phe 
            20                  25                  30          


Thr Glu Ser Ser Ser Asp Lys Ser Ser Ser Ile Leu Ala Ser Gly Ser 
        35                  40                  45              


Ser Arg Gly Phe His Gly Asp Ser Val Val Gln Gln Ile Asp Met Ala 
    50                  55                  60                  


Phe Gly Asn Ser Asn Arg Gln Glu Ile Asp Glu Asp Leu His Ser Arg 
65                  70                  75                  80  


Gln Leu Ala Val Tyr Gly Arg Glu Thr Met Arg Arg Leu Phe Ala Ser 
                85                  90                  95      


Asn Val Leu Ile Ser Gly Met His Gly Leu Gly Ala Glu Ile Ala Lys 
            100                 105                 110         


Asn Leu Ile Leu Ala Gly Val Lys Ser Val Thr Leu His Asp Glu Arg 
        115                 120                 125             


Val Val Glu Leu Trp Asp Leu Ser Ser Asn Phe Val Phe Ser Glu Asp 
    130                 135                 140                 


Asp Val Gly Lys Asn Arg Ala Asp Ala Ser Val Gln Lys Leu Gln Asp 
145                 150                 155                 160 


Leu Asn Asn Ala Val Val Val Ser Ser Leu Thr Lys Ser Leu Asn Lys 
                165                 170                 175     


Glu Asp Leu Ser Gly Phe Gln Val Val Val Phe Ser Asp Ile Ser Met 
            180                 185                 190         


Glu Arg Ala Ile Glu Phe Asp Asp Tyr Cys His Ser His Gln Pro Pro 
        195                 200                 205             


Ile Ala Phe Val Lys Ala Asp Val Arg Gly Leu Phe Gly Ser Val Phe 
    210                 215                 220                 


Cys Asp Phe Gly Pro Glu Phe Ala Val Leu Asp Val Asp Gly Glu Glu 
225                 230                 235                 240 


Pro His Thr Gly Ile Ile Ala Ser Ile Ser Asn Glu Asn Gln Ala Phe 
                245                 250                 255     


Ile Ser Cys Val Asp Asp Glu Arg Leu Glu Phe Glu Asp Gly Asp Leu 
            260                 265                 270         


Val Val Phe Ser Glu Val Glu Gly Met Thr Glu Leu Asn Asp Gly Lys 
        275                 280                 285             


Pro Arg Lys Ile Lys Ser Thr Arg Pro Tyr Ser Phe Thr Leu Asp Glu 
    290                 295                 300                 


Asp Thr Thr Asn Tyr Gly Thr Tyr Val Lys Gly Gly Ile Val Thr Gln 
305                 310                 315                 320 


Val Lys Gln Pro Lys Leu Leu Asn Phe Lys Pro Leu Arg Glu Ala Leu 
                325                 330                 335     


Lys Asp Pro Gly Asp Phe Leu Phe Ser Asp Phe Ser Lys Phe Asp Arg 
            340                 345                 350         


Pro Pro Leu Leu His Leu Ala Phe Gln Ala Leu Asp His Phe Lys Ala 
        355                 360                 365             


Glu Ala Gly Arg Phe Pro Val Ala Gly Ser Glu Glu Asp Ala Gln Lys 
    370                 375                 380                 


Leu Ile Ser Ile Ala Thr Ala Ile Asn Thr Gly Gln Gly Asp Leu Lys 
385                 390                 395                 400 


Val Glu Asn Val Asp Gln Lys Leu Leu Arg His Phe Ser Phe Gly Ala 
                405                 410                 415     


Lys Ala Val Leu Asn Pro Met Ala Ala Met Phe Gly Gly Ile Val Gly 
            420                 425                 430         


Gln Glu Val Val Lys Ala Cys Ser Gly Lys Phe His Pro Leu Phe Gln 
        435                 440                 445             


Phe Phe Tyr Phe Asp Ser Val Glu Ser Leu Pro Ser Glu Pro Val Asp 
    450                 455                 460                 


Ser Ser Asp Phe Ala Pro Arg Asn Ser Arg Tyr Asp Ala Gln Ile Ser 
465                 470                 475                 480 


Val Phe Gly Ala Lys Phe Gln Lys Lys Leu Glu Asp Ala Lys Val Phe 
                485                 490                 495     


Thr Val Gly Ser Gly Ala Leu Gly Cys Glu Phe Leu Lys Asn Leu Ala 
            500                 505                 510         


Leu Met Gly Val Ser Cys Gly Ser Gln Gly Lys Leu Thr Val Thr Asp 
        515                 520                 525             


Asp Asp Ile Ile Glu Lys Ser Asn Leu Ser Arg Gln Phe Leu Phe Arg 
    530                 535                 540                 


Asp Trp Asn Ile Gly Gln Ala Lys Ser Thr Val Ala Ala Ser Ala Ala 
545                 550                 555                 560 


Ala Val Ile Asn Pro Arg Phe Asn Ile Glu Ala Leu Gln Asn Arg Val 
                565                 570                 575     


Gly Ala Glu Thr Glu Asn Val Phe Asp Asp Ala Phe Trp Glu Asn Leu 
            580                 585                 590         


Thr Val Val Val Asn Ala Leu Asp Asn Val Asn Ala Arg Leu Tyr Val 
        595                 600                 605             


Asp Ser Arg Cys Leu Tyr Phe Gln Lys Pro Leu Leu Glu Ser Gly Thr 
    610                 615                 620                 


Leu Gly Thr Lys Cys Asn Thr Gln Ser Val Ile Pro His Leu Thr Glu 
625                 630                 635                 640 


Asn Tyr Gly Ala Ser Arg Asp Pro Pro Glu Lys Gln Ala Pro Met Cys 
                645                 650                 655     


Thr Val His Ser Phe Pro His Asn Ile Asp His Cys Leu Thr Trp Ala 
            660                 665                 670         


Arg Ser Glu Phe Glu Gly Leu Leu Glu Lys Thr Pro Ala Glu Val Asn 
        675                 680                 685             


Ala Tyr Leu Ser Ser Pro Val Glu Tyr Thr Asn Ser Met Met Ser Ala 
    690                 695                 700                 


Gly Asp Ala Gln Ala Arg Asp Thr Leu Glu Arg Ile Val Glu Cys Leu 
705                 710                 715                 720 


Glu Lys Glu Lys Cys Glu Thr Phe Gln Asp Cys Leu Thr Trp Ala Arg 
                725                 730                 735     


Leu Arg Phe Glu Asp Tyr Phe Val Asn Arg Val Lys Gln Leu Ile Tyr 
            740                 745                 750         


Thr Phe Pro Glu Asp Ala Ala Thr Ser Thr Gly Ala Pro Phe Trp Ser 
        755                 760                 765             


Ala Pro Lys Arg Phe Pro Arg Pro Leu Gln Tyr Ser Ser Ser Asp Pro 
    770                 775                 780                 


Ser Leu Leu Asn Phe Ile Thr Ala Thr Ala Ile Leu Arg Ala Glu Thr 
785                 790                 795                 800 


Phe Gly Ile Pro Ile Pro Glu Trp Thr Lys Asn Pro Lys Glu Ala Ala 
                805                 810                 815     


Glu Ala Val Asp Arg Val Ile Val Pro Asp Phe Glu Pro Arg Gln Asp 
            820                 825                 830         


Ala Lys Ile Val Thr Asp Glu Lys Ala Thr Thr Leu Thr Thr Ala Ser 
        835                 840                 845             


Val Asp Asp Ala Ala Val Ile Asp Asp Leu Ile Ala Lys Ile Asp Gln 
    850                 855                 860                 


Cys Arg His Asn Leu Ser Pro Asp Phe Arg Met Lys Pro Ile Gln Phe 
865                 870                 875                 880 


Glu Lys Asp Asp Asp Thr Asn Tyr His Met Asp Val Ile Ala Gly Leu 
                885                 890                 895     


Ala Asn Met Arg Ala Arg Asn Tyr Ser Ile Pro Glu Val Asp Lys Leu 
            900                 905                 910         


Lys Ala Lys Phe Ile Ala Gly Arg Ile Ile Pro Ala Ile Ala Thr Ser 
        915                 920                 925             


Thr Ala Met Ala Thr Gly Leu Val Cys Leu Glu Leu Tyr Lys Val Leu 
    930                 935                 940                 


Asp Gly Gly His Lys Val Glu Ala Tyr Arg Asn Thr Phe Ala Asn Leu 
945                 950                 955                 960 


Ala Leu Pro Leu Phe Ser Met Ala Glu Pro Leu Pro Pro Lys Val Val 
                965                 970                 975     


Lys His Arg Asp Met Ala Trp Thr Val Trp Asp Arg Trp Val Leu Lys 
            980                 985                 990         


Gly Asn Pro Thr Leu Arg Glu Val  Leu Gln Trp Leu Glu  Asp Lys Gly 
        995                 1000                 1005             


Leu Ser  Ala Tyr Ser Ile Ser  Cys Gly Ser Cys Leu  Leu Phe Asn 
    1010                 1015                 1020             


Ser Met  Phe Thr Arg His Lys  Glu Arg Met Asp Lys  Lys Val Val 
    1025                 1030                 1035             


Asp Leu  Ala Arg Asp Val Ala  Lys Val Glu Leu Pro  Pro Tyr Arg 
    1040                 1045                 1050             


Asn His  Leu Asp Val Val Val  Ala Cys Glu Asp Glu  Asp Asp Asn 
    1055                 1060                 1065             


Asp Val  Asp Ile Pro Leu Val  Ser Ile Tyr Phe Arg  
    1070                 1075                 1080 


<210>  16
<211>  1058
<212>  PRT
<213>  Rattus norvegicus

<400>  16

Met Ser Ser Ser Pro Leu Ser Lys Lys Arg Arg Val Ser Gly Pro Asp 
1               5                   10                  15      


Pro Lys Pro Gly Ser Asn Cys Ser Ser Ala Gln Ser Val Leu Ser Glu 
            20                  25                  30          


Val Ser Ser Val Pro Thr Asn Gly Met Ala Lys Asn Gly Ser Glu Ala 
        35                  40                  45              


Asp Ile Asp Glu Ser Leu Tyr Ser Arg Gln Leu Tyr Val Leu Gly His 
    50                  55                  60                  


Glu Ala Met Lys Met Leu Gln Thr Ser Ser Val Leu Val Ser Gly Leu 
65                  70                  75                  80  


Arg Gly Leu Gly Val Glu Ile Ala Lys Asn Ile Ile Leu Gly Gly Val 
                85                  90                  95      


Lys Ala Val Thr Leu His Asp Gln Gly Thr Thr Gln Trp Ala Asp Leu 
            100                 105                 110         


Ser Ser Gln Phe Tyr Leu Arg Glu Glu Asp Ile Gly Lys Asn Arg Ala 
        115                 120                 125             


Glu Val Ser Gln Pro Arg Leu Ala Glu Leu Asn Ser Tyr Val Pro Val 
    130                 135                 140                 


Thr Ala Tyr Thr Gly Pro Leu Val Glu Asp Phe Leu Ser Gly Phe Gln 
145                 150                 155                 160 


Val Val Val Leu Thr Asn Ser Pro Leu Glu Glu Gln Leu Arg Val Gly 
                165                 170                 175     


Glu Phe Cys His Ser Arg Gly Ile Lys Leu Val Val Ala Asp Thr Arg 
            180                 185                 190         


Gly Leu Phe Gly Gln Leu Phe Cys Asp Phe Gly Glu Glu Met Val Leu 
        195                 200                 205             


Thr Asp Ser Asn Gly Glu Gln Pro Leu Ser Ala Met Val Ser Met Val 
    210                 215                 220                 


Thr Lys Asp Asn Pro Gly Val Val Thr Cys Leu Asp Glu Ala Arg His 
225                 230                 235                 240 


Gly Phe Glu Thr Gly Asp Phe Val Ser Phe Ser Glu Val Gln Gly Met 
                245                 250                 255     


Val Gln Leu Asn Gly Cys Gln Pro Ile Glu Ile Lys Val Leu Gly Pro 
            260                 265                 270         


Tyr Thr Phe Ser Ile Cys Asp Thr Ser Asn Phe Ser Asp Tyr Ile Arg 
        275                 280                 285             


Gly Gly Ile Val Ser Gln Val Lys Val Pro Lys Lys Ile Ser Phe Lys 
    290                 295                 300                 


Ser Leu Pro Ala Ser Leu Ala Glu Pro Asp Phe Val Met Thr Asp Phe 
305                 310                 315                 320 


Ala Lys Tyr Ser Arg Pro Ala Gln Leu His Ile Gly Phe Gln Ala Leu 
                325                 330                 335     


His Gln Phe Cys Ala Gln His Asn Arg Pro Pro Arg Pro Arg Asn Glu 
            340                 345                 350         


Glu Asp Ala Thr Glu Leu Val Thr Leu Ala Gln Ala Val Asn Ala Arg 
        355                 360                 365             


Ser Pro Pro Ala Val Gln Gln Asp Asn Val Asp Glu Asp Leu Ile Arg 
    370                 375                 380                 


Lys Leu Ala Tyr Val Ala Ala Gly Asp Leu Ala Pro Ile Asn Ala Phe 
385                 390                 395                 400 


Ile Gly Gly Leu Ala Ala Gln Glu Val Met Lys Ala Cys Ser Gly Lys 
                405                 410                 415     


Phe Met Pro Ile Met Gln Trp Leu Tyr Phe Asp Ala Leu Glu Cys Leu 
            420                 425                 430         


Pro Glu Asp Lys Glu Ala Leu Thr Glu Asp Lys Cys Leu Pro Arg Gln 
        435                 440                 445             


Asn Arg Tyr Asp Gly Gln Val Ala Val Phe Gly Ser Asp Leu Gln Glu 
    450                 455                 460                 


Lys Leu Gly Lys Gln Lys Tyr Phe Leu Val Gly Ala Gly Ala Ile Gly 
465                 470                 475                 480 


Cys Glu Leu Leu Lys Asn Phe Ala Met Ile Gly Leu Gly Cys Gly Glu 
                485                 490                 495     


Gly Gly Glu Val Val Val Thr Asp Met Asp Thr Ile Glu Lys Ser Asn 
            500                 505                 510         


Leu Asn Arg Gln Phe Leu Phe Arg Pro Trp Asp Val Thr Lys Leu Lys 
        515                 520                 525             


Ser Asp Thr Ala Ala Ala Ala Val Arg Gln Met Asn Pro Tyr Ile Gln 
    530                 535                 540                 


Val Thr Ser His Gln Asn Arg Val Gly Pro Asp Thr Glu Arg Ile Tyr 
545                 550                 555                 560 


Asp Asp Asp Phe Phe Gln Asn Leu Asp Gly Val Ala Asn Ala Leu Asp 
                565                 570                 575     


Asn Val Asp Ala Arg Met Tyr Met Asp Arg Arg Cys Val Tyr Tyr Arg 
            580                 585                 590         


Lys Pro Leu Leu Glu Ser Gly Thr Leu Gly Thr Lys Gly Asn Val Gln 
        595                 600                 605             


Val Val Ile Pro Phe Leu Thr Glu Ser Tyr Ser Ser Ser Gln Asp Pro 
    610                 615                 620                 


Pro Glu Lys Ser Ile Pro Ile Cys Thr Leu Lys Asn Phe Pro Asn Ala 
625                 630                 635                 640 


Ile Glu His Thr Leu Gln Trp Ala Arg Asp Glu Phe Glu Gly Leu Phe 
                645                 650                 655     


Lys Gln Pro Ala Glu Asn Val Asn Gln Tyr Leu Thr Asp Ser Lys Phe 
            660                 665                 670         


Val Glu Arg Thr Leu Arg Leu Ala Gly Thr Gln Pro Leu Glu Val Leu 
        675                 680                 685             


Glu Ala Val Gln Arg Ser Leu Val Leu Gln Arg Pro Gln Thr Trp Gly 
    690                 695                 700                 


Asp Cys Val Thr Trp Ala Cys His His Trp His Thr Gln Tyr Cys Asn 
705                 710                 715                 720 


Asn Ile Arg Gln Leu Leu His Asn Phe Pro Pro Asp Gln Leu Thr Ser 
                725                 730                 735     


Ser Gly Ala Pro Phe Trp Ser Gly Pro Lys Arg Cys Pro His Pro Leu 
            740                 745                 750         


Thr Phe Asp Val Asn Asn Thr Leu His Leu Asp Tyr Val Met Ala Ala 
        755                 760                 765             


Ala Asn Leu Phe Ala Gln Thr Tyr Gly Leu Thr Gly Ser Gln Asp Arg 
    770                 775                 780                 


Ala Ala Val Ala Ser Leu Leu Gln Ser Val Gln Val Pro Glu Phe Thr 
785                 790                 795                 800 


Pro Lys Ser Gly Val Lys Ile His Val Ser Asp Gln Glu Leu Gln Ser 
                805                 810                 815     


Ala Asn Ala Ser Val Asp Asp Ser Arg Leu Glu Glu Leu Lys Ala Thr 
            820                 825                 830         


Leu Pro Ser Pro Asp Lys Leu Pro Gly Phe Lys Met Tyr Pro Ile Asp 
        835                 840                 845             


Phe Glu Lys Asp Asp Asp Ser Asn Phe His Met Asp Phe Ile Val Ala 
    850                 855                 860                 


Ala Ser Asn Leu Arg Ala Glu Asn Tyr Asp Ile Ser Pro Ala Asp Arg 
865                 870                 875                 880 


His Lys Ser Lys Leu Ile Ala Gly Lys Ile Ile Pro Ala Ile Ala Thr 
                885                 890                 895     


Thr Thr Ala Ala Val Val Gly Leu Val Cys Leu Glu Leu Tyr Lys Val 
            900                 905                 910         


Val Gln Gly His Gln Gln Leu Asp Ser Tyr Lys Asn Gly Phe Leu Asn 
        915                 920                 925             


Leu Ala Leu Pro Phe Phe Gly Phe Ser Glu Pro Leu Ala Ala Pro Arg 
    930                 935                 940                 


His Gln Tyr Tyr Asn Gln Glu Trp Thr Leu Trp Asp Arg Phe Glu Val 
945                 950                 955                 960 


Gln Gly Leu Gln Pro Asn Gly Glu Glu Met Thr Leu Lys Gln Phe Leu 
                965                 970                 975     


Asp Tyr Phe Lys Thr Glu His Lys Leu Glu Ile Thr Met Leu Ser Gln 
            980                 985                 990         


Gly Val Ser Met Leu Tyr Ser Phe  Phe Met Pro Ala Ala  Lys Leu Lys 
        995                 1000                 1005             


Glu Arg  Leu Asp Gln Pro Met  Thr Glu Ile Val Ser  Arg Val Ser 
    1010                 1015                 1020             


Lys Arg  Lys Leu Gly Arg His  Val Arg Ala Leu Val  Leu Glu Leu 
    1025                 1030                 1035             


Cys Cys  Asn Asp Glu Ser Gly  Glu Asp Val Glu Val  Pro Tyr Val 
    1040                 1045                 1050             


Arg Tyr  Thr Ile Arg 
    1055             


<210>  17
<211>  148
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  17

Met Ser Ser Ser Lys Arg Ile Ala Lys Glu Leu Ser Asp Leu Gly Arg 
1               5                   10                  15      


Asp Pro Pro Ala Ser Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Tyr 
            20                  25                  30          


His Trp Gln Ala Ser Ile Met Gly Pro Ser Asp Ser Pro Tyr Ala Gly 
        35                  40                  45              


Gly Val Phe Phe Leu Ser Ile His Phe Pro Thr Asp Tyr Pro Phe Lys 
    50                  55                  60                  


Pro Pro Lys Val Asn Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn 
65                  70                  75                  80  


Ser Ser Gly Asn Ile Cys Leu Asp Ile Leu Lys Asp Gln Trp Ser Pro 
                85                  90                  95      


Ala Leu Thr Leu Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Thr 
            100                 105                 110         


Asp Ala Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Gln Ile Tyr 
        115                 120                 125             


Lys Thr Asp Lys Ala Lys Tyr Glu Ala Thr Ala Lys Glu Trp Thr Lys 
    130                 135                 140                 


Lys Tyr Ala Val 
145             


<210>  18
<211>  185
<212>  PRT
<213>  Arabidopsis lyrata

<400>  18

Met Ser Ser Pro Ser Lys Arg Arg Glu Met Asp Leu Met Lys Leu Met 
1               5                   10                  15      


Met Ser Asp Tyr Lys Val Glu Met Ile Asn Asp Gly Met Gln Glu Phe 
            20                  25                  30          


Tyr Val Glu Phe Asn Gly Pro Lys Asp Ser Ile Tyr Glu Gly Gly Val 
        35                  40                  45              


Trp Lys Ile Arg Val Glu Leu Pro Asp Ala Tyr Pro Tyr Lys Ser Pro 
    50                  55                  60                  


Ser Val Gly Phe Ile Thr Lys Ile Tyr His Pro Asn Val Asp Glu Met 
65                  70                  75                  80  


Ser Gly Ser Val Cys Leu Asp Val Ile Asn Gln Thr Trp Ser Pro Met 
                85                  90                  95      


Phe Asp Leu Val Asn Val Phe Glu Thr Phe Leu Pro Gln Leu Leu Leu 
            100                 105                 110         


Tyr Pro Asn Pro Ser Asp Pro Leu Asn Gly Glu Ala Ala Ala Leu Met 
        115                 120                 125             


Met Arg Asp Arg Pro Thr Tyr Glu Gln Arg Val Lys Glu Tyr Cys Glu 
    130                 135                 140                 


Lys Tyr Ala Lys Pro Arg Ala Asp Thr Glu Glu Met Ser Ser Asp Asp 
145                 150                 155                 160 


Glu Met Ser Glu Asp Glu Tyr Ala Ser Asp Cys Asp Asp Glu Asp Asp 
                165                 170                 175     


Val Ala Ile Ala Gly Lys Leu Asp Pro 
            180                 185 


<210>  19
<211>  148
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  19

Met Ser Ser Ser Lys Arg Ile Ala Lys Glu Leu Ser Asp Leu Glu Arg 
1               5                   10                  15      


Asp Pro Pro Thr Ser Cys Ser Ala Gly Pro Val Gly Asp Asp Leu Tyr 
            20                  25                  30          


His Trp Gln Ala Ser Ile Met Gly Pro Ala Asp Ser Pro Tyr Ala Gly 
        35                  40                  45              


Gly Val Phe Phe Leu Ser Ile His Phe Pro Thr Asp Tyr Pro Phe Lys 
    50                  55                  60                  


Pro Pro Lys Ile Ser Phe Thr Thr Lys Ile Tyr His Pro Asn Ile Asn 
65                  70                  75                  80  


Ala Asn Gly Asn Ile Cys Leu Asp Ile Leu Lys Asp Gln Trp Ser Pro 
                85                  90                  95      


Ala Leu Thr Leu Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Thr 
            100                 105                 110         


Asp Ala Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala His Ile Tyr 
        115                 120                 125             


Lys Thr Asp Arg Pro Lys Tyr Glu Ala Thr Ala Arg Glu Trp Thr Lys 
    130                 135                 140                 


Lys Tyr Ala Val 
145             


<210>  20
<211>  170
<212>  PRT
<213>  Arabidopsis thaliana

<400>  20

Met Met Ser Asp Tyr Lys Val Glu Met Ile Asn Asp Gly Met Gln Glu 
1               5                   10                  15      


Phe Phe Val Glu Phe Ser Gly Pro Lys Asp Ser Ile Tyr Glu Gly Gly 
            20                  25                  30          


Val Trp Lys Ile Arg Val Glu Leu Pro Asp Ala Tyr Pro Tyr Lys Ser 
        35                  40                  45              


Pro Ser Val Gly Phe Ile Thr Lys Ile Tyr His Pro Asn Val Asp Glu 
    50                  55                  60                  


Met Ser Gly Ser Val Cys Leu Asp Val Ile Asn Gln Thr Trp Ser Pro 
65                  70                  75                  80  


Met Phe Asp Leu Val Asn Val Phe Glu Thr Phe Leu Pro Gln Leu Leu 
                85                  90                  95      


Leu Tyr Pro Asn Pro Ser Asp Pro Leu Asn Gly Glu Ala Ala Ala Leu 
            100                 105                 110         


Met Met Arg Asp Arg Pro Thr Tyr Glu Gln Arg Val Lys Glu Tyr Cys 
        115                 120                 125             


Glu Lys Tyr Ala Lys Pro Arg Ala Asp Thr Glu Glu Met Ser Ser Asp 
    130                 135                 140                 


Asp Glu Met Ser Glu Asp Glu Tyr Ala Ser Asp Gly Asp Asp Glu Asp 
145                 150                 155                 160 


Asp Val Ala Ile Ala Gly Lys Leu Asp Pro 
                165                 170 


<210>  21
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Arg Pro Leu Val Pro Ser Ser Gln Lys Ala Leu Leu Leu Glu 
1               5                   10                  15      


Leu Lys Gly Leu Gln Glu Glu Pro Val Glu Gly Phe Arg Val Thr Leu 
            20                  25                  30          


Val Asp Glu Gly Asp Leu Tyr Asn Trp Glu Val Ala Ile Phe Gly Pro 
        35                  40                  45              


Pro Asn Thr Tyr Tyr Glu Gly Gly Tyr Phe Lys Ala Arg Leu Lys Phe 
    50                  55                  60                  


Pro Ile Asp Tyr Pro Tyr Ser Pro Pro Ala Phe Arg Phe Leu Thr Lys 
65                  70                  75                  80  


Met Trp His Pro Asn Ile Tyr Glu Thr Gly Asp Val Cys Ile Ser Ile 
                85                  90                  95      


Leu His Pro Pro Val Asp Asp Pro Gln Ser Gly Glu Leu Pro Ser Glu 
            100                 105                 110         


Arg Trp Asn Pro Thr Gln Asn Val Arg Thr Ile Leu Leu Ser Val Ile 
        115                 120                 125             


Ser Leu Leu Asn Glu Pro Asn Thr Phe Ser Pro Ala Asn Val Asp Ala 
    130                 135                 140                 


Ser Val Met Tyr Arg Lys Trp Lys Glu Ser Lys Gly Lys Asp Arg Glu 
145                 150                 155                 160 


Tyr Thr Asp Ile Ile Arg Lys Gln Val Leu Gly Thr Lys Val Asp Ala 
                165                 170                 175     


Glu Arg Asp Gly Val Lys Val Pro Thr Thr Leu Ala Glu Tyr Cys Val 
            180                 185                 190         


Lys Thr Lys Ala Pro Ala Pro Asp Glu Gly Ser Asp Leu Phe Tyr Asp 
        195                 200                 205             


Asp Tyr Tyr Glu Asp Gly Glu Val Glu Glu Glu Ala Asp Ser Cys Phe 
    210                 215                 220                 


Gly Asp Asp Glu Asp Asp Ser Gly Thr Glu Glu Ser 
225                 230                 235     


<210>  22
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Leu Lys Arg Ile His Lys Glu Leu Asn Asp Leu Ala Arg Asp 
1               5                   10                  15      


Pro Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Met Phe His 
            20                  25                  30          


Trp Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly 
        35                  40                  45              


Val Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
    50                  55                  60                  


Pro Lys Val Ala Phe Thr Thr Arg Ile Tyr His Pro Asn Ile Asn Ser 
65                  70                  75                  80  


Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                85                  90                  95      


Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
            100                 105                 110         


Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Arg Ile Tyr Lys 
        115                 120                 125             


Thr Asp Arg Glu Lys Tyr Asn Arg Ile Ala Arg Glu Trp Thr Gln Lys 
    130                 135                 140                 


Tyr Ala Met 
145         


<210>  23
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Leu Lys Arg Ile Asn Lys Glu Leu Ser Asp Leu Ala Arg Asp 
1               5                   10                  15      


Pro Pro Ala Gln Cys Ser Ala Gly Pro Val Gly Asp Asp Met Phe His 
            20                  25                  30          


Trp Gln Ala Thr Ile Met Gly Pro Asn Asp Ser Pro Tyr Gln Gly Gly 
        35                  40                  45              


Val Phe Phe Leu Thr Ile His Phe Pro Thr Asp Tyr Pro Phe Lys Pro 
    50                  55                  60                  


Pro Lys Val Ala Phe Thr Thr Arg Ile Tyr His Pro Asn Ile Asn Ser 
65                  70                  75                  80  


Asn Gly Ser Ile Cys Leu Asp Ile Leu Arg Ser Gln Trp Ser Pro Ala 
                85                  90                  95      


Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Cys Asp 
            100                 105                 110         


Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala Arg Ile Tyr Lys 
        115                 120                 125             


Thr Asp Arg Asp Lys Tyr Asn Arg Ile Ser Arg Glu Trp Thr Gln Lys 
    130                 135                 140                 


Tyr Ala Met 
145         


<210>  24
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Asn Ile Ala Val Gln Arg Ile Lys Arg Glu Phe Lys Glu Val 
1               5                   10                  15      


Leu Lys Ser Glu Glu Thr Ser Lys Asn Gln Ile Lys Val Asp Leu Val 
            20                  25                  30          


Asp Glu Asn Phe Thr Glu Leu Arg Gly Glu Ile Ala Gly Pro Pro Asp 
        35                  40                  45              


Thr Pro Tyr Glu Gly Gly Arg Tyr Gln Leu Glu Ile Lys Ile Pro Glu 
    50                  55                  60                  


Thr Tyr Pro Phe Asn Pro Pro Lys Val Arg Phe Ile Thr Lys Ile Trp 
65                  70                  75                  80  


His Pro Asn Ile Ser Ser Val Thr Gly Ala Ile Cys Leu Asp Ile Leu 
                85                  90                  95      


Lys Asp Gln Trp Ala Ala Ala Met Thr Leu Arg Thr Val Leu Leu Ser 
            100                 105                 110         


Leu Gln Ala Leu Leu Ala Ala Ala Glu Pro Asp Asp Pro Gln Asp Ala 
        115                 120                 125             


Val Val Ala Asn Gln Tyr Lys Gln Asn Pro Glu Met Phe Lys Gln Thr 
    130                 135                 140                 


Ala Arg Leu Trp Ala His Val Tyr Ala Gly Ala Pro Val Ser Ser Pro 
145                 150                 155                 160 


Glu Tyr Thr Lys Lys Ile Glu Asn Leu Cys Ala Met Gly Phe Asp Arg 
                165                 170                 175     


Asn Ala Val Ile Val Ala Leu Ser Ser Lys Ser Trp Asp Val Glu Thr 
            180                 185                 190         


Ala Thr Glu Leu Leu Leu Ser Asn 
        195                 200 


<210>  25
<211>  428
<212>  PRT
<213>  Arabidopsis thaliana

<400>  25

Met Ala Thr Ala Phe Ala Pro Thr Lys Leu Thr Ala Thr Val Pro Leu 
1               5                   10                  15      


His Gly Ser His Glu Asn Arg Leu Leu Leu Pro Ile Arg Leu Ala Pro 
            20                  25                  30          


Pro Ser Ser Phe Leu Gly Ser Thr Arg Ser Leu Ser Leu Arg Arg Leu 
        35                  40                  45              


Asn His Ser Asn Ala Thr Arg Arg Ser Pro Val Val Ser Val Gln Glu 
    50                  55                  60                  


Val Val Lys Glu Lys Gln Ser Thr Asn Asn Thr Ser Leu Leu Ile Thr 
65                  70                  75                  80  


Lys Glu Glu Gly Leu Glu Leu Tyr Glu Asp Met Ile Leu Gly Arg Ser 
                85                  90                  95      


Phe Glu Asp Met Cys Ala Gln Met Tyr Tyr Arg Gly Lys Met Phe Gly 
            100                 105                 110         


Phe Val His Leu Tyr Asn Gly Gln Glu Ala Val Ser Thr Gly Phe Ile 
        115                 120                 125             


Lys Leu Leu Thr Lys Ser Asp Ser Val Val Ser Thr Tyr Arg Asp His 
    130                 135                 140                 


Val His Ala Leu Ser Lys Gly Val Ser Ala Arg Ala Val Met Ser Glu 
145                 150                 155                 160 


Leu Phe Gly Lys Val Thr Gly Cys Cys Arg Gly Gln Gly Gly Ser Met 
                165                 170                 175     


His Met Phe Ser Lys Glu His Asn Met Leu Gly Gly Phe Ala Phe Ile 
            180                 185                 190         


Gly Glu Gly Ile Pro Val Ala Thr Gly Ala Ala Phe Ser Ser Lys Tyr 
        195                 200                 205             


Arg Arg Glu Val Leu Lys Gln Asp Cys Asp Asp Val Thr Val Ala Phe 
    210                 215                 220                 


Phe Gly Asp Gly Thr Cys Asn Asn Gly Gln Phe Phe Glu Cys Leu Asn 
225                 230                 235                 240 


Met Ala Ala Leu Tyr Lys Leu Pro Ile Ile Phe Val Val Glu Asn Asn 
                245                 250                 255     


Leu Trp Ala Ile Gly Met Ser His Leu Arg Ala Thr Ser Asp Pro Glu 
            260                 265                 270         


Ile Trp Lys Lys Gly Pro Ala Phe Gly Met Pro Gly Val His Val Asp 
        275                 280                 285             


Gly Met Asp Val Leu Lys Val Arg Glu Val Ala Lys Glu Ala Val Thr 
    290                 295                 300                 


Arg Ala Arg Arg Gly Glu Gly Pro Thr Leu Val Glu Cys Glu Thr Tyr 
305                 310                 315                 320 


Arg Phe Arg Gly His Ser Leu Ala Asp Pro Asp Glu Leu Arg Asp Ala 
                325                 330                 335     


Ala Glu Lys Ala Lys Tyr Ala Ala Arg Asp Pro Ile Ala Ala Leu Lys 
            340                 345                 350         


Lys Tyr Leu Ile Glu Asn Lys Leu Ala Lys Glu Ala Glu Leu Lys Ser 
        355                 360                 365             


Ile Glu Lys Lys Ile Asp Glu Leu Val Glu Glu Ala Val Glu Phe Ala 
    370                 375                 380                 


Asp Ala Ser Pro Gln Pro Gly Arg Ser Gln Leu Leu Glu Asn Val Phe 
385                 390                 395                 400 


Ala Asp Pro Lys Gly Phe Gly Ile Gly Pro Asp Gly Arg Tyr Arg Cys 
                405                 410                 415     


Glu Asp Pro Lys Phe Thr Glu Gly Thr Ala Gln Val 
            420                 425             


<210>  26
<211>  235
<212>  PRT
<213>  Mus musculus

<400>  26

Met Ala Arg Pro Leu Val Pro Ser Ser Gln Lys Ala Leu Leu Leu Glu 
1               5                   10                  15      


Leu Lys Gly Leu Gln Glu Glu Pro Val Glu Gly Phe Arg Val Thr Leu 
            20                  25                  30          


Val Asp Glu Gly Asp Leu Tyr Asn Trp Glu Val Ala Ile Phe Gly Pro 
        35                  40                  45              


Pro Asn Thr Tyr Tyr Glu Gly Gly Tyr Phe Lys Ala Arg Leu Lys Phe 
    50                  55                  60                  


Pro Ile Asp Tyr Pro Tyr Ser Pro Pro Ala Phe Arg Phe Leu Thr Lys 
65                  70                  75                  80  


Met Trp His Pro Asn Ile Tyr Glu Thr Gly Asp Val Cys Ile Ser Ile 
                85                  90                  95      


Leu His Pro Pro Val Asp Asp Pro Gln Ser Gly Glu Leu Pro Ser Glu 
            100                 105                 110         


Arg Trp Asn Pro Thr Gln Asn Val Arg Thr Ile Leu Leu Ser Val Ile 
        115                 120                 125             


Ser Leu Leu Asn Glu Pro Asn Thr Phe Ser Pro Ala Asn Val Asp Ala 
    130                 135                 140                 


Ser Val Met Tyr Arg Lys Trp Lys Glu Ser Lys Gly Lys Asp Arg Glu 
145                 150                 155                 160 


Tyr Thr Asp Ile Ile Arg Lys Gln Val Leu Gly Thr Lys Val Asp Ala 
                165                 170                 175     


Glu Arg Asp Gly Val Lys Val Pro Thr Thr Leu Ala Glu Tyr Cys Val 
            180                 185                 190         


Lys Thr Lys Ala Pro Ala Pro Asp Glu Gly Ser Asp Leu Phe Tyr Asp 
        195                 200                 205             


Asp Tyr Tyr Glu Asp Gly Glu Val Glu Glu Ala Asp Ser Cys Phe Gly 
    210                 215                 220                 


Asp Glu Glu Asp Asp Ser Gly Thr Glu Glu Ser 
225                 230                 235 


<210>  27
<211>  172
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  27

Met Ser Thr Pro Ala Arg Arg Arg Leu Met Arg Asp Phe Lys Arg Met 
1               5                   10                  15      


Lys Glu Asp Ala Pro Pro Gly Val Ser Ala Ser Pro Leu Pro Asp Asn 
            20                  25                  30          


Val Met Val Trp Asn Ala Met Ile Ile Gly Pro Ala Asp Thr Pro Tyr 
        35                  40                  45              


Glu Asp Gly Thr Phe Arg Leu Leu Leu Glu Phe Asp Glu Glu Tyr Pro 
    50                  55                  60                  


Asn Lys Pro Pro His Val Lys Phe Leu Ser Glu Met Phe His Pro Asn 
65                  70                  75                  80  


Val Tyr Ala Asn Gly Glu Ile Cys Leu Asp Ile Leu Gln Asn Arg Trp 
                85                  90                  95      


Thr Pro Thr Tyr Asp Val Ala Ser Ile Leu Thr Ser Ile Gln Ser Leu 
            100                 105                 110         


Phe Asn Asp Pro Asn Pro Ala Ser Pro Ala Asn Val Glu Ala Ala Thr 
        115                 120                 125             


Leu Phe Lys Asp His Lys Ser Gln Tyr Val Lys Arg Val Lys Glu Thr 
    130                 135                 140                 


Val Glu Lys Ser Trp Glu Asp Asp Met Asp Asp Met Asp Asp Asp Asp 
145                 150                 155                 160 


Asp Asp Asp Asp Asp Asp Asp Asp Asp Glu Ala Asp 
                165                 170         


<210>  28
<211>  200
<212>  PRT
<213>  Mus musculus

<400>  28

Met Ala Asn Ile Ala Val Gln Arg Ile Lys Arg Glu Phe Lys Glu Val 
1               5                   10                  15      


Leu Lys Ser Glu Glu Thr Ser Lys Asn Gln Ile Lys Val Asp Leu Val 
            20                  25                  30          


Asp Glu Asn Phe Thr Glu Leu Arg Gly Glu Ile Ala Gly Pro Pro Asp 
        35                  40                  45              


Thr Pro Tyr Glu Gly Gly Arg Tyr Gln Leu Glu Ile Lys Ile Pro Glu 
    50                  55                  60                  


Thr Tyr Pro Phe Asn Pro Pro Lys Val Arg Phe Ile Thr Lys Ile Trp 
65                  70                  75                  80  


His Pro Asn Ile Ser Ser Val Thr Gly Ala Ile Cys Leu Asp Ile Leu 
                85                  90                  95      


Lys Asp Gln Trp Ala Ala Ala Met Thr Leu Arg Thr Val Leu Leu Ser 
            100                 105                 110         


Leu Gln Ala Leu Leu Ala Ala Ala Glu Pro Asp Asp Pro Gln Asp Ala 
        115                 120                 125             


Val Val Ala Asn Gln Tyr Lys Gln Asn Pro Glu Met Phe Lys Gln Thr 
    130                 135                 140                 


Ala Arg Leu Trp Ala His Val Tyr Ala Gly Ala Pro Val Ser Ser Pro 
145                 150                 155                 160 


Glu Tyr Thr Lys Lys Ile Glu Asn Leu Cys Ala Met Gly Phe Asp Arg 
                165                 170                 175     


Asn Ala Val Ile Val Ala Leu Ser Ser Lys Ser Trp Asp Val Glu Thr 
            180                 185                 190         


Ala Thr Glu Leu Leu Leu Ser Asn 
        195                 200 


<210>  29
<211>  153
<212>  PRT
<213>  Arabidopsis thaliana

<400>  29

Met Ala Asn Ser Asn Leu Pro Arg Arg Ile Ile Lys Glu Thr Gln Arg 
1               5                   10                  15      


Leu Leu Ser Glu Pro Ala Pro Gly Ile Ser Ala Ser Pro Ser Glu Asp 
            20                  25                  30          


Asn Met Arg Tyr Phe Asn Val Met Ile Leu Gly Pro Thr Gln Ser Pro 
        35                  40                  45              


Tyr Glu Gly Gly Val Phe Lys Leu Glu Leu Phe Leu Pro Glu Glu Tyr 
    50                  55                  60                  


Pro Met Ala Ala Pro Lys Val Arg Phe Leu Thr Lys Ile Tyr His Pro 
65                  70                  75                  80  


Asn Ile Asp Lys Leu Gly Arg Ile Cys Leu Asp Ile Leu Lys Asp Lys 
                85                  90                  95      


Trp Ser Pro Ala Leu Gln Ile Arg Thr Val Leu Leu Ser Ile Gln Ala 
            100                 105                 110         


Leu Leu Ser Ala Pro Asn Pro Asp Asp Pro Leu Ser Glu Asn Ile Ala 
        115                 120                 125             


Lys His Trp Lys Ser Asn Glu Ala Glu Ala Val Asp Thr Ala Lys Glu 
    130                 135                 140                 


Trp Thr Arg Leu Tyr Ala Ser Gly Ala 
145                 150             


<210>  30
<211>  295
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  30

Met Ser Ser Arg Lys Ser Thr Ala Ser Ser Leu Leu Leu Arg Gln Tyr 
1               5                   10                  15      


Arg Glu Leu Thr Asp Pro Lys Lys Ala Ile Pro Ser Phe His Ile Glu 
            20                  25                  30          


Leu Glu Asp Asp Ser Asn Ile Phe Thr Trp Asn Ile Gly Val Met Val 
        35                  40                  45              


Leu Asn Glu Asp Ser Ile Tyr His Gly Gly Phe Phe Lys Ala Gln Met 
    50                  55                  60                  


Arg Phe Pro Glu Asp Phe Pro Phe Ser Pro Pro Gln Phe Arg Phe Thr 
65                  70                  75                  80  


Pro Ala Ile Tyr His Pro Asn Val Tyr Arg Asp Gly Arg Leu Cys Ile 
                85                  90                  95      


Ser Ile Leu His Gln Ser Gly Asp Pro Met Thr Asp Glu Pro Asp Ala 
            100                 105                 110         


Glu Thr Trp Ser Pro Val Gln Thr Val Glu Ser Val Leu Ile Ser Ile 
        115                 120                 125             


Val Ser Leu Leu Glu Asp Pro Asn Ile Asn Ser Pro Ala Asn Val Asp 
    130                 135                 140                 


Ala Ala Val Asp Tyr Arg Lys Asn Pro Glu Gln Tyr Lys Gln Arg Val 
145                 150                 155                 160 


Lys Met Glu Val Glu Arg Ser Lys Gln Asp Ile Pro Lys Gly Phe Ile 
                165                 170                 175     


Met Pro Thr Ser Glu Ser Ala Tyr Ile Ser Gln Ser Lys Leu Asp Glu 
            180                 185                 190         


Pro Glu Ser Asn Lys Asp Met Ala Asp Asn Phe Trp Tyr Asp Ser Asp 
        195                 200                 205             


Leu Asp Asp Asp Glu Asn Gly Ser Val Ile Leu Gln Asp Asp Asp Tyr 
    210                 215                 220                 


Asp Asp Gly Asn Asn His Ile Pro Phe Glu Asp Asp Asp Val Tyr Asn 
225                 230                 235                 240 


Tyr Asn Asp Asn Asp Asp Asp Asp Glu Arg Ile Glu Phe Glu Asp Asp 
                245                 250                 255     


Asp Asp Asp Asp Asp Asp Ser Ile Asp Asn Asp Ser Val Met Asp Arg 
            260                 265                 270         


Lys Gln Pro His Lys Ala Glu Asp Glu Ser Glu Asp Val Glu Asp Val 
        275                 280                 285             


Glu Arg Val Ser Lys Lys Ile 
    290                 295 


<210>  31
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Val Ser Thr Gly Val Lys Val Pro Arg Asn Phe Arg Leu Leu 
1               5                   10                  15      


Glu Glu Leu Glu Glu Gly Gln Lys Gly Val Gly Asp Gly Thr Val Ser 
            20                  25                  30          


Trp Gly Leu Glu Asp Asp Glu Asp Met Thr Leu Thr Arg Trp Thr Gly 
        35                  40                  45              


Met Ile Ile Gly Pro Pro Arg Thr Asn Tyr Glu Asn Arg Ile Tyr Ser 
    50                  55                  60                  


Leu Lys Val Glu Cys Gly Pro Lys Tyr Pro Glu Ala Pro Pro Ser Val 
65                  70                  75                  80  


Arg Phe Val Thr Lys Ile Asn Met Asn Gly Ile Asn Asn Ser Ser Gly 
                85                  90                  95      


Met Val Asp Ala Arg Ser Ile Pro Val Leu Ala Lys Trp Gln Asn Ser 
            100                 105                 110         


Tyr Ser Ile Lys Val Val Leu Gln Glu Leu Arg Arg Leu Met Met Ser 
        115                 120                 125             


Lys Glu Asn Met Lys Leu Pro Gln Pro Pro Glu Gly Gln Thr Tyr Asn 
    130                 135                 140                 


Asn 
145 


<210>  32
<211>  215
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  32

Met Ser Arg Ala Lys Arg Ile Met Lys Glu Ile Gln Ala Val Lys Asp 
1               5                   10                  15      


Asp Pro Ala Ala His Ile Thr Leu Glu Phe Val Ser Glu Ser Asp Ile 
            20                  25                  30          


His His Leu Lys Gly Thr Phe Leu Gly Pro Pro Gly Thr Pro Tyr Glu 
        35                  40                  45              


Gly Gly Lys Phe Val Val Asp Ile Glu Val Pro Met Glu Tyr Pro Phe 
    50                  55                  60                  


Lys Pro Pro Lys Met Gln Phe Asp Thr Lys Val Tyr His Pro Asn Ile 
65                  70                  75                  80  


Ser Ser Val Thr Gly Ala Ile Cys Leu Asp Ile Leu Lys Asn Ala Trp 
                85                  90                  95      


Ser Pro Val Ile Thr Leu Lys Ser Ala Leu Ile Ser Leu Gln Ala Leu 
            100                 105                 110         


Leu Gln Ser Pro Glu Pro Asn Asp Pro Gln Asp Ala Glu Val Ala Gln 
        115                 120                 125             


His Tyr Leu Arg Asp Arg Glu Ser Phe Asn Lys Thr Ala Ala Leu Trp 
    130                 135                 140                 


Thr Arg Leu Tyr Ala Ser Glu Thr Ser Asn Gly Gln Lys Gly Asn Val 
145                 150                 155                 160 


Glu Glu Ser Asp Leu Tyr Gly Ile Asp His Asp Leu Ile Asp Glu Phe 
                165                 170                 175     


Glu Ser Gln Gly Phe Glu Lys Asp Lys Ile Val Glu Val Leu Arg Arg 
            180                 185                 190         


Leu Gly Val Lys Ser Leu Asp Pro Asn Asp Asn Asn Thr Ala Asn Arg 
        195                 200                 205             


Ile Ile Glu Glu Leu Leu Lys 
    210                 215 


<210>  33
<211>  250
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  33

Met Ala Thr Lys Gln Ala His Lys Arg Leu Thr Lys Glu Tyr Lys Leu 
1               5                   10                  15      


Met Val Glu Asn Pro Pro Pro Tyr Ile Leu Ala Arg Pro Asn Glu Asp 
            20                  25                  30          


Asn Ile Leu Glu Trp His Tyr Ile Ile Thr Gly Pro Ala Asp Thr Pro 
        35                  40                  45              


Tyr Lys Gly Gly Gln Tyr His Gly Thr Leu Thr Phe Pro Ser Asp Tyr 
    50                  55                  60                  


Pro Tyr Lys Pro Pro Ala Ile Arg Met Ile Thr Pro Asn Gly Arg Phe 
65                  70                  75                  80  


Lys Pro Asn Thr Arg Leu Cys Leu Ser Met Ser Asp Tyr His Pro Asp 
                85                  90                  95      


Thr Trp Asn Pro Gly Trp Ser Val Ser Thr Ile Leu Asn Gly Leu Leu 
            100                 105                 110         


Ser Phe Met Thr Ser Asp Glu Ala Thr Thr Gly Ser Ile Thr Thr Ser 
        115                 120                 125             


Asp His Gln Lys Lys Thr Leu Ala Arg Asn Ser Ile Ser Tyr Asn Thr 
    130                 135                 140                 


Phe Gln Asn Val Arg Phe Lys Leu Ile Phe Pro Glu Val Val Gln Glu 
145                 150                 155                 160 


Asn Val Glu Thr Leu Glu Lys Arg Lys Leu Asp Glu Gly Asp Ala Ala 
                165                 170                 175     


Asn Thr Gly Asp Glu Thr Glu Asp Pro Phe Thr Lys Ala Ala Lys Glu 
            180                 185                 190         


Lys Val Ile Ser Leu Glu Glu Ile Leu Asp Pro Glu Asp Arg Ile Arg 
        195                 200                 205             


Ala Glu Gln Ala Leu Arg Gln Ser Glu Asn Asn Ser Lys Lys Asp Gly 
    210                 215                 220                 


Lys Glu Pro Asn Asp Ser Ser Ser Met Val Tyr Ile Gly Ile Ala Ile 
225                 230                 235                 240 


Phe Leu Phe Leu Val Gly Leu Phe Met Lys 
                245                 250 


<210>  34
<211>  148
<212>  PRT
<213>  Arabidopsis thaliana

<400>  34

Met Ala Ser Lys Arg Ile Leu Lys Glu Leu Lys Asp Leu Gln Lys Asp 
1               5                   10                  15      


Pro Pro Thr Ser Cys Ser Ala Gly Pro Val Ala Glu Asp Met Phe His 
            20                  25                  30          


Trp Gln Ala Thr Ile Met Gly Pro Ser Glu Ser Pro Tyr Ala Gly Gly 
        35                  40                  45              


Val Phe Leu Val Thr Ile His Phe Pro Pro Asp Tyr Pro Phe Lys Pro 
    50                  55                  60                  


Pro Lys Val Ala Phe Arg Thr Lys Val Phe His Pro Asn Ile Asn Ser 
65                  70                  75                  80  


Asn Gly Ser Ile Cys Leu Asp Ile Leu Lys Glu Gln Trp Ser Pro Ala 
                85                  90                  95      


Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Thr Asp 
            100                 105                 110         


Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala His Met Tyr Lys 
        115                 120                 125             


Thr Asp Lys Asn Lys Tyr Glu Ser Thr Ala Arg Ser Trp Thr Gln Lys 
    130                 135                 140                 


Tyr Ala Met Gly 
145             


<210>  35
<211>  318
<212>  PRT
<213>  Mus musculus

<400>  35

Met Glu Thr Arg Tyr Asn Leu Lys Ser Pro Ala Val Lys Arg Leu Met 
1               5                   10                  15      


Lys Glu Ala Ala Glu Leu Lys Asp Pro Thr Asp His Tyr His Ala Gln 
            20                  25                  30          


Pro Leu Glu Asp Asn Leu Phe Glu Trp His Phe Thr Val Arg Gly Pro 
        35                  40                  45              


Pro Asp Ser Asp Phe Asp Gly Gly Val Tyr His Gly Arg Ile Val Leu 
    50                  55                  60                  


Pro Pro Glu Tyr Pro Met Lys Pro Pro Ser Ile Ile Leu Leu Thr Ala 
65                  70                  75                  80  


Asn Gly Arg Phe Glu Val Gly Lys Lys Ile Cys Leu Ser Ile Ser Gly 
                85                  90                  95      


His His Pro Glu Thr Trp Gln Pro Ser Trp Ser Ile Arg Thr Ala Leu 
            100                 105                 110         


Leu Ala Ile Ile Gly Phe Met Pro Thr Lys Gly Glu Gly Ala Ile Gly 
        115                 120                 125             


Ser Leu Asp Tyr Thr Pro Glu Glu Arg Arg Ala Leu Ala Lys Lys Ser 
    130                 135                 140                 


Gln Asp Phe Cys Cys Glu Gly Cys Gly Ser Ala Met Lys Asp Val Leu 
145                 150                 155                 160 


Leu Pro Leu Lys Ser Gly Ser Gly Ser Ser Gln Ala Asp Gln Glu Ala 
                165                 170                 175     


Lys Glu Leu Ala Arg Gln Ile Ser Phe Lys Ala Glu Val Asn Ser Ser 
            180                 185                 190         


Gly Lys Thr Ile Ala Glu Ser Asp Leu Asn Gln Cys Phe Ser Leu Asn 
        195                 200                 205             


Asp Ser Gln Asp Asp Leu Pro Thr Thr Phe Gln Gly Ala Thr Ala Ser 
    210                 215                 220                 


Thr Ser Tyr Gly Ala Gln Asn Pro Ser Gly Ala Pro Leu Pro Gln Pro 
225                 230                 235                 240 


Thr Gln Pro Ala Pro Lys Asn Thr Ser Met Ser Pro Arg Gln Arg Arg 
                245                 250                 255     


Ala Gln Gln Gln Ser Gln Arg Arg Pro Ser Thr Ser Pro Asp Val Leu 
            260                 265                 270         


Gln Gly Gln Pro Pro Arg Ala His His Thr Glu His Gly Gly Ser Ala 
        275                 280                 285             


Met Leu Ile Ile Ile Leu Thr Leu Ala Leu Ala Ala Leu Ile Phe Arg 
    290                 295                 300                 


Arg Ile Tyr Leu Ala Asn Glu Tyr Ile Phe Asp Phe Glu Leu 
305                 310                 315             


<210>  36
<211>  148
<212>  PRT
<213>  Arabidopsis thaliana

<400>  36

Met Ala Ser Lys Arg Ile Leu Lys Glu Leu Lys Asp Leu Gln Lys Asp 
1               5                   10                  15      


Pro Pro Ser Asn Cys Ser Ala Gly Pro Val Ala Glu Asp Met Phe His 
            20                  25                  30          


Trp Gln Ala Thr Ile Met Gly Pro Pro Glu Ser Pro Tyr Ala Gly Gly 
        35                  40                  45              


Val Phe Leu Val Ser Ile His Phe Pro Pro Asp Tyr Pro Phe Lys Pro 
    50                  55                  60                  


Pro Lys Val Ser Phe Lys Thr Lys Val Tyr His Pro Asn Ile Asn Ser 
65                  70                  75                  80  


Asn Gly Ser Ile Cys Leu Asp Ile Leu Lys Glu Gln Trp Ser Pro Ala 
                85                  90                  95      


Leu Thr Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Thr Asp 
            100                 105                 110         


Pro Asn Pro Asp Asp Pro Leu Val Pro Glu Ile Ala His Met Tyr Lys 
        115                 120                 125             


Thr Asp Arg Ser Lys Tyr Glu Ser Thr Ala Arg Ser Trp Thr Gln Lys 
    130                 135                 140                 


Tyr Ala Met Gly 
145             


<210>  37
<211>  491
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys 
    50                  55                  60                  


Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val Lys Glu His 
                85                  90                  95      


Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val Val Asn Gln 
            100                 105                 110         


Gln Glu Ser Ser Asp Ser Gly Thr Ser Val Ser Glu Asn Arg Cys His 
        115                 120                 125             


Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu Val Gln Glu Leu Gln Glu 
    130                 135                 140                 


Glu Lys Pro Ser Ser Ser His Leu Val Ser Arg Pro Ser Thr Ser Ser 
145                 150                 155                 160 


Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu Asn Ser Asp Glu Leu Ser 
                165                 170                 175     


Gly Glu Arg Gln Arg Lys Arg His Lys Ser Asp Ser Ile Ser Leu Ser 
            180                 185                 190         


Phe Asp Glu Ser Leu Ala Leu Cys Val Ile Arg Glu Ile Cys Cys Glu 
        195                 200                 205             


Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr Pro Ser Asn Pro Asp Leu 
    210                 215                 220                 


Asp Ala Gly Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser 
225                 230                 235                 240 


Val Ser Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser 
                245                 250                 255     


Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp 
            260                 265                 270         


Asp Glu Val Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu Ser Asp Thr 
        275                 280                 285             


Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys 
    290                 295                 300                 


Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn 
305                 310                 315                 320 


Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys 
                325                 330                 335     


Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln 
            340                 345                 350         


Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn 
        355                 360                 365             


Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln 
    370                 375                 380                 


Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser 
385                 390                 395                 400 


Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg 
                405                 410                 415     


Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu 
            420                 425                 430         


Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly 
        435                 440                 445             


Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys 
    450                 455                 460                 


Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln 
465                 470                 475                 480 


Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
                485                 490     


<210>  38
<211>  465
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ile Val Phe Val Arg Phe Asn Ser Ser His Gly Phe Pro Val Glu 
1               5                   10                  15      


Val Asp Ser Asp Thr Ser Ile Phe Gln Leu Lys Glu Val Val Ala Lys 
            20                  25                  30          


Arg Gln Gly Val Pro Ala Asp Gln Leu Arg Val Ile Phe Ala Gly Lys 
        35                  40                  45              


Glu Leu Arg Asn Asp Trp Thr Val Gln Asn Cys Asp Leu Asp Gln Gln 
    50                  55                  60                  


Ser Ile Val His Ile Val Gln Arg Pro Trp Arg Lys Gly Gln Glu Met 
65                  70                  75                  80  


Asn Ala Thr Gly Gly Asp Asp Pro Arg Asn Ala Ala Gly Gly Cys Glu 
                85                  90                  95      


Arg Glu Pro Gln Ser Leu Thr Arg Val Asp Leu Ser Ser Ser Val Leu 
            100                 105                 110         


Pro Gly Asp Ser Val Gly Leu Ala Val Ile Leu His Thr Asp Ser Arg 
        115                 120                 125             


Lys Asp Ser Pro Pro Ala Gly Ser Pro Ala Gly Arg Ser Ile Tyr Asn 
    130                 135                 140                 


Ser Phe Tyr Val Tyr Cys Lys Gly Pro Cys Gln Arg Val Gln Pro Gly 
145                 150                 155                 160 


Lys Leu Arg Val Gln Cys Ser Thr Cys Arg Gln Ala Thr Leu Thr Leu 
                165                 170                 175     


Thr Gln Gly Pro Ser Cys Trp Asp Asp Val Leu Ile Pro Asn Arg Met 
            180                 185                 190         


Ser Gly Glu Cys Gln Ser Pro His Cys Pro Gly Thr Ser Ala Glu Phe 
        195                 200                 205             


Phe Phe Lys Cys Gly Ala His Pro Thr Ser Asp Lys Glu Thr Ser Val 
    210                 215                 220                 


Ala Leu His Leu Ile Ala Thr Asn Ser Arg Asn Ile Thr Cys Ile Thr 
225                 230                 235                 240 


Cys Thr Asp Val Arg Ser Pro Val Leu Val Phe Gln Cys Asn Ser Arg 
                245                 250                 255     


His Val Ile Cys Leu Asp Cys Phe His Leu Tyr Cys Val Thr Arg Leu 
            260                 265                 270         


Asn Asp Arg Gln Phe Val His Asp Pro Gln Leu Gly Tyr Ser Leu Pro 
        275                 280                 285             


Cys Val Ala Gly Cys Pro Asn Ser Leu Ile Lys Glu Leu His His Phe 
    290                 295                 300                 


Arg Ile Leu Gly Glu Glu Gln Tyr Asn Arg Tyr Gln Gln Tyr Gly Ala 
305                 310                 315                 320 


Glu Glu Cys Val Leu Gln Met Gly Gly Val Leu Cys Pro Arg Pro Gly 
                325                 330                 335     


Cys Gly Ala Gly Leu Leu Pro Glu Pro Asp Gln Arg Lys Val Thr Cys 
            340                 345                 350         


Glu Gly Gly Asn Gly Leu Gly Cys Gly Phe Ala Phe Cys Arg Glu Cys 
        355                 360                 365             


Lys Glu Ala Tyr His Glu Gly Glu Cys Ser Ala Val Phe Glu Ala Ser 
    370                 375                 380                 


Gly Thr Thr Thr Gln Ala Tyr Arg Val Asp Glu Arg Ala Ala Glu Gln 
385                 390                 395                 400 


Ala Arg Trp Glu Ala Ala Ser Lys Glu Thr Ile Lys Lys Thr Thr Lys 
                405                 410                 415     


Pro Cys Pro Arg Cys His Val Pro Val Glu Lys Asn Gly Gly Cys Met 
            420                 425                 430         


His Met Lys Cys Pro Gln Pro Gln Cys Arg Leu Glu Trp Cys Trp Asn 
        435                 440                 445             


Cys Gly Cys Glu Trp Asn Arg Val Cys Met Gly Asp His Trp Phe Asp 
    450                 455                 460                 


Val 
465 


<210>  39
<211>  1863
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  40
<211>  809
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  40

Met Pro Ser Ser Ile Ser Val Lys Leu Val Ala Ala Glu Ser Leu Tyr 
1               5                   10                  15      


Lys Arg Asp Val Phe Arg Ser Pro Asp Pro Phe Ala Val Leu Thr Ile 
            20                  25                  30          


Asp Gly Tyr Gln Thr Lys Ser Thr Ser Ala Ala Lys Lys Thr Leu Asn 
        35                  40                  45              


Pro Tyr Trp Asn Glu Thr Phe Lys Phe Asp Asp Ile Asn Glu Asn Ser 
    50                  55                  60                  


Ile Leu Thr Ile Gln Val Phe Asp Gln Lys Lys Phe Lys Lys Lys Asp 
65                  70                  75                  80  


Gln Gly Phe Leu Gly Val Val Asn Val Arg Val Gly Asp Val Leu Gly 
                85                  90                  95      


His Leu Asp Glu Asp Thr Ala Thr Ser Ser Gly Arg Pro Arg Glu Glu 
            100                 105                 110         


Thr Ile Thr Arg Asp Leu Lys Lys Ser Asn Asp Gly Met Ala Val Ser 
        115                 120                 125             


Gly Arg Leu Ile Val Val Leu Ser Lys Leu Pro Ser Ser Ser Pro His 
    130                 135                 140                 


Ser Gln Ala Pro Ser Gly His Thr Ala Ser Ser Ser Thr Asn Thr Ser 
145                 150                 155                 160 


Ser Thr Thr Arg Thr Asn Gly His Ser Thr Ser Ser Thr Arg Asn His 
                165                 170                 175     


Ser Thr Ser His Pro Ser Arg Gly Thr Ala Gln Ala Val Glu Ser Thr 
            180                 185                 190         


Leu Gln Ser Gly Thr Thr Ala Ala Thr Asn Thr Ala Thr Thr Ser His 
        195                 200                 205             


Arg Ser Thr Asn Ser Thr Ser Ser Ala Thr Arg Gln Tyr Ser Ser Phe 
    210                 215                 220                 


Glu Asp Gln Tyr Gly Arg Leu Pro Pro Gly Trp Glu Arg Arg Thr Asp 
225                 230                 235                 240 


Asn Phe Gly Arg Thr Tyr Tyr Val Asp His Asn Thr Arg Thr Thr Thr 
                245                 250                 255     


Trp Lys Arg Pro Thr Leu Asp Gln Thr Glu Ala Glu Arg Gly Asn Gln 
            260                 265                 270         


Leu Asn Ala Asn Thr Glu Leu Glu Arg Arg Gln His Arg Gly Arg Thr 
        275                 280                 285             


Leu Pro Gly Gly Ser Ser Asp Asn Ser Ser Val Thr Val Gln Val Gly 
    290                 295                 300                 


Gly Gly Ser Asn Ile Pro Pro Val Asn Gly Ala Ala Ala Ala Ala Phe 
305                 310                 315                 320 


Ala Ala Thr Gly Gly Thr Thr Ser Gly Leu Gly Glu Leu Pro Ser Gly 
                325                 330                 335     


Trp Glu Gln Arg Phe Thr Pro Glu Gly Arg Ala Tyr Phe Val Asp His 
            340                 345                 350         


Asn Thr Arg Thr Thr Thr Trp Val Asp Pro Arg Arg Gln Gln Tyr Ile 
        355                 360                 365             


Arg Thr Tyr Gly Pro Thr Asn Thr Thr Ile Gln Gln Gln Pro Val Ser 
    370                 375                 380                 


Gln Leu Gly Pro Leu Pro Ser Gly Trp Glu Met Arg Leu Thr Asn Thr 
385                 390                 395                 400 


Ala Arg Val Tyr Phe Val Asp His Asn Thr Lys Thr Thr Thr Trp Asp 
                405                 410                 415     


Asp Pro Arg Leu Pro Ser Ser Leu Asp Gln Asn Val Pro Gln Tyr Lys 
            420                 425                 430         


Arg Asp Phe Arg Arg Lys Val Ile Tyr Phe Arg Ser Gln Pro Ala Leu 
        435                 440                 445             


Arg Ile Leu Pro Gly Gln Cys His Ile Lys Val Arg Arg Lys Asn Ile 
    450                 455                 460                 


Phe Glu Asp Ala Tyr Gln Glu Ile Met Arg Gln Thr Pro Glu Asp Leu 
465                 470                 475                 480 


Lys Lys Arg Leu Met Ile Lys Phe Asp Gly Glu Glu Gly Leu Asp Tyr 
                485                 490                 495     


Gly Gly Val Ser Arg Glu Phe Phe Phe Leu Leu Ser His Glu Met Phe 
            500                 505                 510         


Asn Pro Phe Tyr Cys Leu Phe Glu Tyr Ser Ala Tyr Asp Asn Tyr Thr 
        515                 520                 525             


Ile Gln Ile Asn Pro Asn Ser Gly Ile Asn Pro Glu His Leu Asn Tyr 
    530                 535                 540                 


Phe Lys Phe Ile Gly Arg Val Val Gly Leu Gly Val Phe His Arg Arg 
545                 550                 555                 560 


Phe Leu Asp Ala Phe Phe Val Gly Ala Leu Tyr Lys Met Met Leu Arg 
                565                 570                 575     


Lys Lys Val Val Leu Gln Asp Met Glu Gly Val Asp Ala Glu Val Tyr 
            580                 585                 590         


Asn Ser Leu Asn Trp Met Leu Glu Asn Ser Ile Asp Gly Val Leu Asp 
        595                 600                 605             


Leu Thr Phe Ser Ala Asp Asp Glu Arg Phe Gly Glu Val Val Thr Val 
    610                 615                 620                 


Asp Leu Lys Pro Asp Gly Arg Asn Ile Glu Val Thr Asp Gly Asn Lys 
625                 630                 635                 640 


Lys Glu Tyr Val Glu Leu Tyr Thr Gln Trp Arg Ile Val Asp Arg Val 
                645                 650                 655     


Gln Glu Gln Phe Lys Ala Phe Met Asp Gly Phe Asn Glu Leu Ile Pro 
            660                 665                 670         


Glu Asp Leu Val Thr Val Phe Asp Glu Arg Glu Leu Glu Leu Leu Ile 
        675                 680                 685             


Gly Gly Ile Ala Glu Ile Asp Ile Glu Asp Trp Lys Lys His Thr Asp 
    690                 695                 700                 


Tyr Arg Gly Tyr Gln Glu Ser Asp Glu Val Ile Gln Trp Phe Trp Lys 
705                 710                 715                 720 


Cys Val Ser Glu Trp Asp Asn Glu Gln Arg Ala Arg Leu Leu Gln Phe 
                725                 730                 735     


Thr Thr Gly Thr Ser Arg Ile Pro Val Asn Gly Phe Lys Asp Leu Gln 
            740                 745                 750         


Gly Ser Asp Gly Pro Arg Arg Phe Thr Ile Glu Lys Ala Gly Glu Val 
        755                 760                 765             


Gln Gln Leu Pro Lys Ser His Thr Cys Phe Asn Arg Val Asp Leu Pro 
    770                 775                 780                 


Gln Tyr Val Asp Tyr Asp Ser Met Lys Gln Lys Leu Thr Leu Ala Val 
785                 790                 795                 800 


Glu Glu Thr Ile Gly Phe Gly Gln Glu 
                805                 


<210>  41
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Ala Ala Ser Val Thr Pro Pro Gly Ser Leu Glu Leu Leu Gln 
1               5                   10                  15      


Pro Gly Phe Ser Lys Thr Leu Leu Gly Thr Lys Leu Glu Ala Lys Tyr 
            20                  25                  30          


Leu Cys Ser Ala Cys Arg Asn Val Leu Arg Arg Pro Phe Gln Ala Gln 
        35                  40                  45              


Cys Gly His Arg Tyr Cys Ser Phe Cys Leu Ala Ser Ile Leu Ser Ser 
    50                  55                  60                  


Gly Pro Gln Asn Cys Ala Ala Cys Val His Glu Gly Ile Tyr Glu Glu 
65                  70                  75                  80  


Gly Ile Ser Ile Leu Glu Ser Ser Ser Ala Phe Pro Asp Asn Ala Ala 
                85                  90                  95      


Arg Arg Glu Val Glu Ser Leu Pro Ala Val Cys Pro Ser Asp Gly Cys 
            100                 105                 110         


Thr Trp Lys Gly Thr Leu Lys Glu Tyr Glu Ser Cys His Glu Gly Arg 
        115                 120                 125             


Cys Pro Leu Met Leu Thr Glu Cys Pro Ala Cys Lys Gly Leu Val Arg 
    130                 135                 140                 


Leu Gly Glu Lys Glu Arg His Leu Glu His Glu Cys Pro Glu Arg Ser 
145                 150                 155                 160 


Leu Ser Cys Arg His Cys Arg Ala Pro Cys Cys Gly Ala Asp Val Lys 
                165                 170                 175     


Ala His His Glu Val Cys Pro Lys Phe Pro Leu Thr Cys Asp Gly Cys 
            180                 185                 190         


Gly Lys Lys Lys Ile Pro Arg Glu Lys Phe Gln Asp His Val Lys Thr 
        195                 200                 205             


Cys Gly Lys Cys Arg Val Pro Cys Arg Phe His Ala Ile Gly Cys Leu 
    210                 215                 220                 


Glu Thr Val Glu Gly Glu Lys Gln Gln Glu His Glu Val Gln Trp Leu 
225                 230                 235                 240 


Arg Glu His Leu Ala Met Leu Leu Ser Ser Val Leu Glu Ala Lys Pro 
                245                 250                 255     


Leu Leu Gly Asp Gln Ser His Ala Gly Ser Glu Leu Leu Gln Arg Cys 
            260                 265                 270         


Glu Ser Leu Glu Lys Lys Thr Ala Thr Phe Glu Asn Ile Val Cys Val 
        275                 280                 285             


Leu Asn Arg Glu Val Glu Arg Val Ala Met Thr Ala Glu Ala Cys Ser 
    290                 295                 300                 


Arg Gln His Arg Leu Asp Gln Asp Lys Ile Glu Ala Leu Ser Ser Lys 
305                 310                 315                 320 


Val Gln Gln Leu Glu Arg Ser Ile Gly Leu Lys Asp Leu Ala Met Ala 
                325                 330                 335     


Asp Leu Glu Gln Lys Val Leu Glu Met Glu Ala Ser Thr Tyr Asp Gly 
            340                 345                 350         


Val Phe Ile Trp Lys Ile Ser Asp Phe Ala Arg Lys Arg Gln Glu Ala 
        355                 360                 365             


Val Ala Gly Arg Ile Pro Ala Ile Phe Ser Pro Ala Phe Tyr Thr Ser 
    370                 375                 380                 


Arg Tyr Gly Tyr Lys Met Cys Leu Arg Ile Tyr Leu Asn Gly Asp Gly 
385                 390                 395                 400 


Thr Gly Arg Gly Thr His Leu Ser Leu Phe Phe Val Val Met Lys Gly 
                405                 410                 415     


Pro Asn Asp Ala Leu Leu Arg Trp Pro Phe Asn Gln Lys Val Thr Leu 
            420                 425                 430         


Met Leu Leu Asp Gln Asn Asn Arg Glu His Val Ile Asp Ala Phe Arg 
        435                 440                 445             


Pro Asp Val Thr Ser Ser Ser Phe Gln Arg Pro Val Asn Asp Met Asn 
    450                 455                 460                 


Ile Ala Ser Gly Cys Pro Leu Phe Cys Pro Val Ser Lys Met Glu Ala 
465                 470                 475                 480 


Lys Asn Ser Tyr Val Arg Asp Asp Ala Ile Phe Ile Lys Ala Ile Val 
                485                 490                 495     


Asp Leu Thr Gly Leu 
            500     


<210>  42
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ser Arg Gln Thr Ala Thr Ala Leu Pro Thr Gly Thr Ser Lys Cys 
1               5                   10                  15      


Pro Pro Ser Gln Arg Val Pro Ala Leu Thr Gly Thr Thr Ala Ser Asn 
            20                  25                  30          


Asn Asp Leu Ala Ser Leu Phe Glu Cys Pro Val Cys Phe Asp Tyr Val 
        35                  40                  45              


Leu Pro Pro Ile Leu Gln Cys Gln Ser Gly His Leu Val Cys Ser Asn 
    50                  55                  60                  


Cys Arg Pro Lys Leu Thr Cys Cys Pro Thr Cys Arg Gly Pro Leu Gly 
65                  70                  75                  80  


Ser Ile Arg Asn Leu Ala Met Glu Lys Val Ala Asn Ser Val Leu Phe 
                85                  90                  95      


Pro Cys Lys Tyr Ala Ser Ser Gly Cys Glu Ile Thr Leu Pro His Thr 
            100                 105                 110         


Glu Lys Ala Asp His Glu Glu Leu Cys Glu Phe Arg Pro Tyr Ser Cys 
        115                 120                 125             


Pro Cys Pro Gly Ala Ser Cys Lys Trp Gln Gly Ser Leu Asp Ala Val 
    130                 135                 140                 


Met Pro His Leu Met His Gln His Lys Ser Ile Thr Thr Leu Gln Gly 
145                 150                 155                 160 


Glu Asp Ile Val Phe Leu Ala Thr Asp Ile Asn Leu Pro Gly Ala Val 
                165                 170                 175     


Asp Trp Val Met Met Gln Ser Cys Phe Gly Phe His Phe Met Leu Val 
            180                 185                 190         


Leu Glu Lys Gln Glu Lys Tyr Asp Gly His Gln Gln Phe Phe Ala Ile 
        195                 200                 205             


Val Gln Leu Ile Gly Thr Arg Lys Gln Ala Glu Asn Phe Ala Tyr Arg 
    210                 215                 220                 


Leu Glu Leu Asn Gly His Arg Arg Arg Leu Thr Trp Glu Ala Thr Pro 
225                 230                 235                 240 


Arg Ser Ile His Glu Gly Ile Ala Thr Ala Ile Met Asn Ser Asp Cys 
                245                 250                 255     


Leu Val Phe Asp Thr Ser Ile Ala Gln Leu Phe Ala Glu Asn Gly Asn 
            260                 265                 270         


Leu Gly Ile Asn Val Thr Ile Ser Met Cys 
        275                 280         


<210>  43
<211>  464
<212>  PRT
<213>  Mus musculus

<400>  43

Met Ile Val Phe Val Arg Phe Asn Ser Ser Tyr Gly Phe Pro Val Glu 
1               5                   10                  15      


Val Asp Ser Asp Thr Ser Ile Leu Gln Leu Lys Glu Val Val Ala Lys 
            20                  25                  30          


Arg Gln Gly Val Pro Ala Asp Gln Leu Arg Val Ile Phe Ala Gly Lys 
        35                  40                  45              


Glu Leu Pro Asn His Leu Thr Val Gln Asn Cys Asp Leu Glu Gln Gln 
    50                  55                  60                  


Ser Ile Val His Ile Val Gln Arg Pro Arg Arg Arg Ser His Glu Thr 
65                  70                  75                  80  


Asn Ala Ser Gly Gly Asp Glu Pro Gln Ser Thr Ser Glu Gly Ser Ile 
                85                  90                  95      


Trp Glu Ser Arg Ser Leu Thr Arg Val Asp Leu Ser Ser His Thr Leu 
            100                 105                 110         


Pro Val Asp Ser Val Gly Leu Ala Val Ile Leu Asp Thr Asp Ser Lys 
        115                 120                 125             


Arg Asp Ser Glu Ala Ala Arg Gly Pro Val Lys Pro Thr Tyr Asn Ser 
    130                 135                 140                 


Phe Phe Ile Tyr Cys Lys Gly Pro Cys His Lys Val Gln Pro Gly Lys 
145                 150                 155                 160 


Leu Arg Val Gln Cys Gly Thr Cys Lys Gln Ala Thr Leu Thr Leu Ala 
                165                 170                 175     


Gln Gly Pro Ser Cys Trp Asp Asp Val Leu Ile Pro Asn Arg Met Ser 
            180                 185                 190         


Gly Glu Cys Gln Ser Pro Asp Cys Pro Gly Thr Arg Ala Glu Phe Phe 
        195                 200                 205             


Phe Lys Cys Gly Ala His Pro Thr Ser Asp Lys Asp Thr Ser Val Ala 
    210                 215                 220                 


Leu Asn Leu Ile Thr Ser Asn Arg Arg Ser Ile Pro Cys Ile Ala Cys 
225                 230                 235                 240 


Thr Asp Val Arg Ser Pro Val Leu Val Phe Gln Cys Asn His Arg His 
                245                 250                 255     


Val Ile Cys Leu Asp Cys Phe His Leu Tyr Cys Val Thr Arg Leu Asn 
            260                 265                 270         


Asp Arg Gln Phe Val His Asp Ala Gln Leu Gly Tyr Ser Leu Pro Cys 
        275                 280                 285             


Val Ala Gly Cys Pro Asn Ser Leu Ile Lys Glu Leu His His Phe Arg 
    290                 295                 300                 


Ile Leu Gly Glu Glu Gln Tyr Thr Arg Tyr Gln Gln Tyr Gly Ala Glu 
305                 310                 315                 320 


Glu Cys Val Leu Gln Met Gly Gly Val Leu Cys Pro Arg Pro Gly Cys 
                325                 330                 335     


Gly Ala Gly Leu Leu Pro Glu Gln Gly Gln Arg Lys Val Thr Cys Glu 
            340                 345                 350         


Gly Gly Asn Gly Leu Gly Cys Gly Phe Val Phe Cys Arg Asp Cys Lys 
        355                 360                 365             


Glu Ala Tyr His Glu Gly Asp Cys Asp Ser Leu Leu Glu Pro Ser Gly 
    370                 375                 380                 


Ala Thr Ser Gln Ala Tyr Arg Val Asp Lys Arg Ala Ala Glu Gln Ala 
385                 390                 395                 400 


Arg Trp Glu Glu Ala Ser Lys Glu Thr Ile Lys Lys Thr Thr Lys Pro 
                405                 410                 415     


Cys Pro Arg Cys Asn Val Pro Ile Glu Lys Asn Gly Gly Cys Met His 
            420                 425                 430         


Met Lys Cys Pro Gln Pro Gln Cys Lys Leu Glu Trp Cys Trp Asn Cys 
        435                 440                 445             


Gly Cys Glu Trp Asn Arg Ala Cys Met Gly Asp His Trp Phe Asp Val 
    450                 455                 460                 


<210>  44
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Lys Gly Lys Glu Glu Lys Glu Gly Gly Ala Arg Leu Gly Ala Gly 
1               5                   10                  15      


Gly Gly Ser Pro Glu Lys Ser Pro Ser Ala Gln Glu Leu Lys Glu Gln 
            20                  25                  30          


Gly Asn Arg Leu Phe Val Gly Arg Lys Tyr Pro Glu Ala Ala Ala Cys 
        35                  40                  45              


Tyr Gly Arg Ala Ile Thr Arg Asn Pro Leu Val Ala Val Tyr Tyr Thr 
    50                  55                  60                  


Asn Arg Ala Leu Cys Tyr Leu Lys Met Gln Gln His Glu Gln Ala Leu 
65                  70                  75                  80  


Ala Asp Cys Arg Arg Ala Leu Glu Leu Asp Gly Gln Ser Val Lys Ala 
                85                  90                  95      


His Phe Phe Leu Gly Gln Cys Gln Leu Glu Met Glu Ser Tyr Asp Glu 
            100                 105                 110         


Ala Ile Ala Asn Leu Gln Arg Ala Tyr Ser Leu Ala Lys Glu Gln Arg 
        115                 120                 125             


Leu Asn Phe Gly Asp Asp Ile Pro Ser Ala Leu Arg Ile Ala Lys Lys 
    130                 135                 140                 


Lys Arg Trp Asn Ser Ile Glu Glu Arg Arg Ile His Gln Glu Ser Glu 
145                 150                 155                 160 


Leu His Ser Tyr Leu Ser Arg Leu Ile Ala Ala Glu Arg Glu Arg Glu 
                165                 170                 175     


Leu Glu Glu Cys Gln Arg Asn His Glu Gly Asp Glu Asp Asp Ser His 
            180                 185                 190         


Val Arg Ala Gln Gln Ala Cys Ile Glu Ala Lys His Asp Lys Tyr Met 
        195                 200                 205             


Ala Asp Met Asp Glu Leu Phe Ser Gln Val Asp Glu Lys Arg Lys Lys 
    210                 215                 220                 


Arg Asp Ile Pro Asp Tyr Leu Cys Gly Lys Ile Ser Phe Glu Leu Met 
225                 230                 235                 240 


Arg Glu Pro Cys Ile Thr Pro Ser Gly Ile Thr Tyr Asp Arg Lys Asp 
                245                 250                 255     


Ile Glu Glu His Leu Gln Arg Val Gly His Phe Asp Pro Val Thr Arg 
            260                 265                 270         


Ser Pro Leu Thr Gln Glu Gln Leu Ile Pro Asn Leu Ala Met Lys Glu 
        275                 280                 285             


Val Ile Asp Ala Phe Ile Ser Glu Asn Gly Trp Val Glu Asp Tyr 
    290                 295                 300             


<210>  45
<211>  1030
<212>  PRT
<213>  Danio rerio

<400>  45

Met Thr Thr Gly Arg Asn Asn Arg Val Met Met Glu Gly Val Gly Ala 
1               5                   10                  15      


Arg Val Ile Arg Gly Pro Asp Trp Lys Trp Gly Lys Gln Asp Gly Gly 
            20                  25                  30          


Glu Gly His Val Gly Thr Val Arg Ser Phe Glu Ser Pro Glu Glu Val 
        35                  40                  45              


Val Val Val Trp Asp Asn Gly Thr Ala Ala Asn Tyr Arg Cys Ser Gly 
    50                  55                  60                  


Ala Tyr Asp Val Arg Ile Leu Asp Ser Ala Pro Thr Gly Ile Lys His 
65                  70                  75                  80  


Asp Gly Thr Met Cys Asp Thr Cys Arg Gln Gln Pro Ile Ile Gly Ile 
                85                  90                  95      


Arg Trp Lys Cys Ala Glu Cys Thr Asn Tyr Asp Leu Cys Thr Thr Cys 
            100                 105                 110         


Tyr His Gly Asp Lys His His Leu Arg His Arg Phe Tyr Arg Ile Thr 
        115                 120                 125             


Thr Pro Gly Ser Glu Arg Val Leu Leu Glu Ser Arg Arg Lys Ser Lys 
    130                 135                 140                 


Lys Ile Thr Ala Arg Gly Ile Phe Ala Gly Gly Arg Val Val Arg Gly 
145                 150                 155                 160 


Val Asp Trp Gln Trp Glu Asp Gln Asp Gly Gly Asn Gly Arg Arg Gly 
                165                 170                 175     


Lys Val Thr Glu Ile Gln Asp Trp Ser Ala Ala Ser Pro His Ser Ala 
            180                 185                 190         


Ala Tyr Val Leu Trp Asp Asn Gly Ala Lys Asn Leu Tyr Arg Val Gly 
        195                 200                 205             


Phe Glu Gly Met Ser Asp Leu Lys Cys Val Gln Asp Ala Lys Gly Gly 
    210                 215                 220                 


Thr Phe Tyr Arg Asp His Cys Pro Val Leu Gly Glu Gln Asn Gly Asn 
225                 230                 235                 240 


Arg Asn Pro Gly Gly Leu Gln Ile Gly Asp Leu Val Asn Ile Asp Leu 
                245                 250                 255     


Asp Leu Glu Ile Val Gln Ser Leu Gln His Gly His Gly Gly Trp Thr 
            260                 265                 270         


Asp Gly Met Phe Glu Thr Leu Thr Thr Thr Gly Thr Val Cys Gly Ile 
        275                 280                 285             


Asp Glu Asp His Asp Ile Val Val Gln Tyr Pro Ser Gly Asn Arg Trp 
    290                 295                 300                 


Thr Phe Asn Pro Ala Val Leu Thr Lys Ala Asn Val Val Arg Ser Gly 
305                 310                 315                 320 


Glu Val Ala Ala Gly Ala Glu Gly Gly Ser Ser Gln Phe Met Val Gly 
                325                 330                 335     


Asp Leu Val Gln Ile Cys Tyr Asp Ile Asp Arg Ile Lys Leu Leu Gln 
            340                 345                 350         


Arg Gly His Gly Glu Trp Ala Glu Ala Met Leu Pro Thr Leu Gly Lys 
        355                 360                 365             


Val Gly Arg Val Gln Gln Ile Tyr Ser Asp Ser Asp Leu Lys Val Glu 
    370                 375                 380                 


Val Cys Gly Thr Ser Trp Thr Tyr Asn Pro Ala Ala Val Thr Lys Val 
385                 390                 395                 400 


Ala Pro Ala Gly Ser Ala Val Thr Asn Ala Ser Gly Glu Arg Leu Ser 
                405                 410                 415     


Gln Leu Leu Lys Lys Leu Phe Glu Thr Gln Glu Ser Gly Asp Ile Asn 
            420                 425                 430         


Glu Glu Leu Val Lys Ala Ala Ala Asn Gly Asp Leu Ala Lys Val Glu 
        435                 440                 445             


Asp Ile Leu Lys Arg Pro Asp Val Asp Val Asn Gly Gln Cys Ala Gly 
    450                 455                 460                 


His Thr Ala Met Gln Ala Ala Ser Gln Asn Gly His Val Asp Val Leu 
465                 470                 475                 480 


Lys Leu Leu Leu Lys His Ser Val Asp Leu Glu Ala Glu Asp Lys Asp 
                485                 490                 495     


Gly Asp Arg Ala Val His His Ala Ser Phe Gly Asp Glu Gly Ser Val 
            500                 505                 510         


Ile Glu Val Leu His Arg Gly Gly Ala Asp Leu Asn Ala Arg Asn Lys 
        515                 520                 525             


Arg Arg Gln Thr Pro Leu His Ile Ala Val Asn Lys Gly His Leu Gln 
    530                 535                 540                 


Val Val Lys Thr Leu Leu Asp Phe Gly Cys His Pro Ser Leu Gln Asp 
545                 550                 555                 560 


Ser Glu Gly Asp Thr Pro Leu His Asp Ala Ile Ser Lys Lys Arg Asp 
                565                 570                 575     


Asp Met Leu Ser Val Leu Leu Glu Ala Gly Ala Asp Val Thr Ile Thr 
            580                 585                 590         


Asn Asn Asn Gly Phe Asn Ala Leu His His Ala Ala Leu Arg Gly Asn 
        595                 600                 605             


Pro Ser Ala Met Arg Val Leu Leu Ser Lys Leu Pro Arg Pro Trp Ile 
    610                 615                 620                 


Val Asp Glu Lys Lys Asp Asp Gly Tyr Thr Ala Leu His Leu Ala Ala 
625                 630                 635                 640 


Leu Asn Asn His Val Glu Val Ala Glu Leu Leu Val His Gln Gly Asn 
                645                 650                 655     


Ala Asn Leu Asp Val Gln Asn Val Asn Gln Gln Thr Ala Leu His Leu 
            660                 665                 670         


Ala Val Glu Arg Gln His Thr Gln Ile Val Arg Leu Leu Val Arg Ala 
        675                 680                 685             


Glu Ala Lys Leu Asp Val Gln Asp Lys Asp Gly Asp Thr Pro Leu His 
    690                 695                 700                 


Glu Ala Leu Arg His His Thr Leu Ser Gln Leu Arg Gln Leu Gln Asp 
705                 710                 715                 720 


Met Gln Asp Val Ser Lys Val Glu Pro Trp Glu Pro Ser Lys Asn Thr 
                725                 730                 735     


Leu Ile Met Gly Leu Gly Thr Gln Gly Ala Glu Lys Lys Ser Ala Ala 
            740                 745                 750         


Ser Ile Ala Cys Phe Leu Ala Ala Asn Gly Ala Asp Leu Thr Ile Arg 
        755                 760                 765             


Asn Lys Lys Gly Gln Ser Pro Leu Asp Leu Cys Pro Asp Pro Ser Leu 
    770                 775                 780                 


Cys Lys Ala Leu Ala Lys Cys His Lys Glu Lys Thr Ser Gly Gln Val 
785                 790                 795                 800 


Gly Ser Arg Ser Pro Ser Leu Asn Ser Asn Asn Glu Thr Leu Glu Glu 
                805                 810                 815     


Cys Met Val Cys Ser Asp Met Lys Arg Asp Thr Leu Phe Gly Pro Cys 
            820                 825                 830         


Gly His Ile Ala Thr Cys Ser Leu Cys Ser Pro Arg Val Lys Lys Cys 
        835                 840                 845             


Leu Ile Cys Lys Glu Gln Val Gln Ser Arg Thr Lys Ile Glu Glu Cys 
    850                 855                 860                 


Val Val Cys Ser Asp Lys Lys Ala Ala Val Leu Phe Gln Pro Cys Gly 
865                 870                 875                 880 


His Met Cys Ala Cys Glu Asn Cys Ala Ser Leu Met Lys Lys Cys Val 
                885                 890                 895     


Gln Cys Arg Ala Val Val Glu Arg Arg Thr Pro Phe Val Leu Cys Cys 
            900                 905                 910         


Gly Gly Lys Gly Met Glu Asp Ala Thr Asp Asp Glu Asp Leu Thr Gly 
        915                 920                 925             


Gly Ser Asn Ser Met Ala Gly Gly Ser Gln Asp Leu Leu Gln Pro Asn 
    930                 935                 940                 


Asn Leu Ala Leu Ser Trp Ser Ser Gly Asn Ile Pro Ala Leu Gln Arg 
945                 950                 955                 960 


Asp Lys Asp Asn Thr Asn Val Asn Ala Asp Val Gln Lys Leu Gln Gln 
                965                 970                 975     


Gln Leu Gln Asp Ile Lys Glu Gln Thr Met Cys Pro Val Cys Leu Asp 
            980                 985                 990         


Arg Leu Lys Asn Met Ile Phe Met  Cys Gly His Gly Thr  Cys Gln Leu 
        995                 1000                 1005             


Cys Gly  Asp Arg Met Ser Glu  Cys Pro Ile Cys Arg  Lys Ala Ile 
    1010                 1015                 1020             


Glu Arg  Arg Ile Leu Leu Tyr  
    1025                 1030 


<210>  46
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ser Asn Pro Gly Thr Arg Arg Asn Gly Ser Ser Ile Lys Ile Arg 
1               5                   10                  15      


Leu Thr Val Leu Cys Ala Lys Asn Leu Ala Lys Lys Asp Phe Phe Arg 
            20                  25                  30          


Leu Pro Asp Pro Phe Ala Lys Ile Val Val Asp Gly Ser Gly Gln Cys 
        35                  40                  45              


His Ser Thr Asp Thr Val Lys Asn Thr Leu Asp Pro Lys Trp Asn Gln 
    50                  55                  60                  


His Tyr Asp Leu Tyr Val Gly Lys Thr Asp Ser Ile Thr Ile Ser Val 
65                  70                  75                  80  


Trp Asn His Lys Lys Ile His Lys Lys Gln Gly Ala Gly Phe Leu Gly 
                85                  90                  95      


Cys Val Arg Leu Leu Ser Asn Ala Ile Ser Arg Leu Lys Asp Thr Gly 
            100                 105                 110         


Tyr Gln Arg Leu Asp Leu Cys Lys Leu Asn Pro Ser Asp Thr Asp Ala 
        115                 120                 125             


Val Arg Gly Gln Ile Val Val Ser Leu Gln Thr Arg Asp Arg Ile Gly 
    130                 135                 140                 


Thr Gly Gly Ser Val Val Asp Cys Arg Gly Leu Leu Glu Asn Glu Gly 
145                 150                 155                 160 


Thr Val Tyr Glu Asp Ser Gly Pro Gly Arg Pro Leu Ser Cys Phe Met 
                165                 170                 175     


Glu Glu Pro Ala Pro Tyr Thr Asp Ser Thr Gly Ala Ala Ala Gly Gly 
            180                 185                 190         


Gly Asn Cys Arg Phe Val Glu Ser Pro Ser Gln Asp Gln Arg Leu Gln 
        195                 200                 205             


Ala Gln Arg Leu Arg Asn Pro Asp Val Arg Gly Ser Leu Gln Thr Pro 
    210                 215                 220                 


Gln Asn Arg Pro His Gly His Gln Ser Pro Glu Leu Pro Glu Gly Tyr 
225                 230                 235                 240 


Glu Gln Arg Thr Thr Val Gln Gly Gln Val Tyr Phe Leu His Thr Gln 
                245                 250                 255     


Thr Gly Val Ser Thr Trp His Asp Pro Arg Ile Pro Ser Pro Ser Gly 
            260                 265                 270         


Thr Ile Pro Gly Gly Asp Ala Ala Phe Leu Tyr Glu Phe Leu Leu Gln 
        275                 280                 285             


Gly His Thr Ser Glu Pro Arg Asp Leu Asn Ser Val Asn Cys Asp Glu 
    290                 295                 300                 


Leu Gly Pro Leu Pro Pro Gly Trp Glu Val Arg Ser Thr Val Ser Gly 
305                 310                 315                 320 


Arg Ile Tyr Phe Val Asp His Asn Asn Arg Thr Thr Gln Phe Thr Asp 
                325                 330                 335     


Pro Arg Leu His His Ile Met Asn His Gln Cys Gln Leu Lys Glu Pro 
            340                 345                 350         


Ser Gln Pro Leu Pro Leu Pro Ser Glu Gly Ser Leu Glu Asp Glu Glu 
        355                 360                 365             


Leu Pro Ala Gln Arg Tyr Glu Arg Asp Leu Val Gln Lys Leu Lys Val 
    370                 375                 380                 


Leu Arg His Glu Leu Ser Leu Gln Gln Pro Gln Ala Gly His Cys Arg 
385                 390                 395                 400 


Ile Glu Val Ser Arg Glu Glu Ile Phe Glu Glu Ser Tyr Arg Gln Ile 
                405                 410                 415     


Met Lys Met Arg Pro Lys Asp Leu Lys Lys Arg Leu Met Val Lys Phe 
            420                 425                 430         


Arg Gly Glu Glu Gly Leu Asp Tyr Gly Gly Val Ala Arg Glu Trp Leu 
        435                 440                 445             


Tyr Leu Leu Cys His Glu Met Leu Asn Pro Tyr Tyr Gly Leu Phe Gln 
    450                 455                 460                 


Tyr Ser Thr Asp Asn Ile Tyr Met Leu Gln Ile Asn Pro Asp Ser Ser 
465                 470                 475                 480 


Ile Asn Pro Asp His Leu Ser Tyr Phe His Phe Val Gly Arg Ile Met 
                485                 490                 495     


Gly Leu Ala Val Phe His Gly His Tyr Ile Asn Gly Gly Phe Thr Val 
            500                 505                 510         


Pro Phe Tyr Lys Gln Leu Leu Gly Lys Pro Ile Gln Leu Ser Asp Leu 
        515                 520                 525             


Glu Ser Val Asp Pro Glu Leu His Lys Ser Leu Val Trp Ile Leu Glu 
    530                 535                 540                 


Asn Asp Ile Thr Pro Val Leu Asp His Thr Phe Cys Val Glu His Asn 
545                 550                 555                 560 


Ala Phe Gly Arg Ile Leu Gln His Glu Leu Lys Pro Asn Gly Arg Asn 
                565                 570                 575     


Val Pro Val Thr Glu Glu Asn Lys Lys Glu Tyr Val Arg Leu Tyr Val 
            580                 585                 590         


Asn Trp Arg Phe Met Arg Gly Ile Glu Ala Gln Phe Leu Ala Leu Gln 
        595                 600                 605             


Lys Gly Phe Asn Glu Leu Ile Pro Gln His Leu Leu Lys Pro Phe Asp 
    610                 615                 620                 


Gln Lys Glu Leu Glu Leu Ile Ile Gly Gly Leu Asp Lys Ile Asp Leu 
625                 630                 635                 640 


Asn Asp Trp Lys Ser Asn Thr Arg Leu Lys His Cys Val Ala Asp Ser 
                645                 650                 655     


Asn Ile Val Arg Trp Phe Trp Gln Ala Val Glu Thr Phe Asp Glu Glu 
            660                 665                 670         


Arg Arg Ala Arg Leu Leu Gln Phe Val Thr Gly Ser Thr Arg Val Pro 
        675                 680                 685             


Leu Gln Gly Phe Lys Ala Leu Gln Gly Ser Thr Gly Ala Ala Gly Pro 
    690                 695                 700                 


Arg Leu Phe Thr Ile His Leu Ile Asp Ala Asn Thr Asp Asn Leu Pro 
705                 710                 715                 720 


Lys Ala His Thr Cys Phe Asn Arg Ile Asp Ile Pro Pro Tyr Glu Ser 
                725                 730                 735     


Tyr Glu Lys Leu Tyr Glu Lys Leu Leu Thr Ala Val Glu Glu Thr Cys 
            740                 745                 750         


Gly Phe Ala Val Glu 
        755         


<210>  47
<211>  1319
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ala Gln Ser Leu Arg Leu His Phe Ala Ala Arg Arg Ser Asn Thr 
1               5                   10                  15      


Tyr Pro Leu Ser Glu Thr Ser Gly Asp Asp Leu Asp Ser His Val His 
            20                  25                  30          


Met Cys Phe Lys Arg Pro Thr Arg Ile Ser Thr Ser Asn Val Val Gln 
        35                  40                  45              


Met Lys Leu Thr Pro Arg Gln Thr Ala Leu Ala Pro Leu Ile Lys Glu 
    50                  55                  60                  


Asn Val Gln Ser Gln Glu Arg Ser Ser Val Pro Ser Ser Glu Asn Val 
65                  70                  75                  80  


Asn Lys Lys Ser Ser Cys Leu Gln Ile Ser Leu Gln Pro Thr Arg Tyr 
                85                  90                  95      


Ser Gly Tyr Leu Gln Ser Ser Asn Val Leu Ala Asp Ser Asp Asp Ala 
            100                 105                 110         


Ser Phe Thr Cys Ile Leu Lys Asp Gly Ile Tyr Ser Ser Ala Val Val 
        115                 120                 125             


Asp Asn Glu Leu Asn Ala Val Asn Asp Gly His Leu Val Ser Ser Pro 
    130                 135                 140                 


Ala Ile Cys Ser Gly Ser Leu Ser Asn Phe Ser Thr Ser Asp Asn Gly 
145                 150                 155                 160 


Ser Tyr Ser Ser Asn Gly Ser Asp Phe Gly Ser Cys Ala Ser Ile Thr 
                165                 170                 175     


Ser Gly Gly Ser Tyr Thr Asn Ser Val Ile Ser Asp Ser Ser Ser Tyr 
            180                 185                 190         


Thr Phe Pro Pro Ser Asp Asp Thr Phe Leu Gly Gly Asn Leu Pro Ser 
        195                 200                 205             


Asp Ser Thr Ser Asn Arg Ser Val Pro Asn Arg Asn Thr Thr Pro Cys 
    210                 215                 220                 


Glu Ile Phe Ser Arg Ser Thr Ser Thr Asp Pro Phe Val Gln Asp Asp 
225                 230                 235                 240 


Leu Glu His Gly Leu Glu Ile Met Lys Leu Pro Val Ser Arg Asn Thr 
                245                 250                 255     


Lys Ile Pro Leu Lys Arg Tyr Ser Ser Leu Val Ile Phe Pro Arg Ser 
            260                 265                 270         


Pro Ser Thr Thr Arg Pro Thr Ser Pro Thr Ser Leu Cys Thr Leu Leu 
        275                 280                 285             


Ser Lys Gly Ser Tyr Gln Thr Ser His Gln Phe Ile Ile Ser Pro Ser 
    290                 295                 300                 


Glu Ile Ala His Asn Glu Asp Gly Thr Ser Ala Lys Gly Phe Leu Ser 
305                 310                 315                 320 


Thr Ala Val Asn Gly Leu Arg Leu Ser Lys Thr Ile Cys Thr Pro Gly 
                325                 330                 335     


Glu Val Arg Asp Ile Arg Pro Leu His Arg Lys Gly Ser Leu Gln Lys 
            340                 345                 350         


Lys Ile Val Leu Ser Asn Asn Thr Pro Arg Gln Thr Val Cys Glu Lys 
        355                 360                 365             


Ser Ser Glu Gly Tyr Ser Cys Val Ser Val His Phe Thr Gln Arg Lys 
    370                 375                 380                 


Ala Ala Thr Leu Asp Cys Glu Thr Thr Asn Gly Asp Cys Lys Pro Glu 
385                 390                 395                 400 


Met Ser Glu Ile Lys Leu Asn Ser Asp Ser Glu Tyr Ile Lys Leu Met 
                405                 410                 415     


His Arg Thr Ser Ala Cys Leu Pro Ser Ser Gln Asn Val Asp Cys Gln 
            420                 425                 430         


Ile Asn Ile Asn Gly Glu Leu Glu Arg Pro His Ser Gln Met Asn Lys 
        435                 440                 445             


Asn His Gly Ile Leu Arg Arg Ser Ile Ser Leu Gly Gly Ala Tyr Pro 
    450                 455                 460                 


Asn Ile Ser Cys Leu Ser Ser Leu Lys His Asn Cys Ser Lys Gly Gly 
465                 470                 475                 480 


Pro Ser Gln Leu Leu Ile Lys Phe Ala Ser Gly Asn Glu Gly Lys Val 
                485                 490                 495     


Asp Asn Leu Ser Arg Asp Ser Asn Arg Asp Cys Thr Asn Glu Leu Ser 
            500                 505                 510         


Asn Ser Cys Lys Thr Arg Asp Asp Phe Leu Gly Gln Val Asp Val Pro 
        515                 520                 525             


Leu Tyr Pro Leu Pro Thr Glu Asn Pro Arg Leu Glu Arg Pro Tyr Thr 
    530                 535                 540                 


Phe Lys Asp Phe Val Leu His Pro Arg Ser His Lys Ser Arg Val Lys 
545                 550                 555                 560 


Gly Tyr Leu Arg Leu Lys Met Thr Tyr Leu Pro Lys Thr Ser Gly Ser 
                565                 570                 575     


Glu Asp Asp Asn Ala Glu Gln Ala Glu Glu Leu Glu Pro Gly Trp Val 
            580                 585                 590         


Val Leu Asp Gln Pro Asp Ala Ala Cys His Leu Gln Gln Gln Gln Glu 
        595                 600                 605             


Pro Ser Pro Leu Pro Pro Gly Trp Glu Glu Arg Gln Asp Ile Leu Gly 
    610                 615                 620                 


Arg Thr Tyr Tyr Val Asn His Glu Ser Arg Arg Thr Gln Trp Lys Arg 
625                 630                 635                 640 


Pro Thr Pro Gln Asp Asn Leu Thr Asp Ala Glu Asn Gly Asn Ile Gln 
                645                 650                 655     


Leu Gln Ala Gln Arg Ala Phe Thr Thr Arg Arg Gln Ile Ser Glu Glu 
            660                 665                 670         


Thr Glu Ser Val Asp Asn Arg Glu Ser Ser Glu Asn Trp Glu Ile Ile 
        675                 680                 685             


Arg Glu Asp Glu Ala Thr Met Tyr Ser Asn Gln Ala Phe Pro Ser Pro 
    690                 695                 700                 


Pro Pro Ser Ser Asn Leu Asp Val Pro Thr His Leu Ala Glu Glu Leu 
705                 710                 715                 720 


Asn Ala Arg Leu Thr Ile Phe Gly Asn Ser Ala Val Ser Gln Pro Ala 
                725                 730                 735     


Ser Ser Ser Asn His Ser Ser Arg Arg Gly Ser Leu Gln Ala Tyr Thr 
            740                 745                 750         


Phe Glu Glu Gln Pro Thr Leu Pro Val Leu Leu Pro Thr Ser Ser Gly 
        755                 760                 765             


Leu Pro Pro Gly Trp Glu Glu Lys Gln Asp Glu Arg Gly Arg Ser Tyr 
    770                 775                 780                 


Tyr Val Asp His Asn Ser Arg Thr Thr Thr Trp Thr Lys Pro Thr Val 
785                 790                 795                 800 


Gln Ala Thr Val Glu Thr Ser Gln Leu Thr Ser Ser Gln Ser Ser Ala 
                805                 810                 815     


Gly Pro Gln Ser Gln Ala Ser Thr Ser Asp Ser Gly Gln Gln Val Thr 
            820                 825                 830         


Gln Pro Ser Glu Ile Glu Gln Gly Phe Leu Pro Lys Gly Trp Glu Val 
        835                 840                 845             


Arg His Ala Pro Asn Gly Arg Pro Phe Phe Ile Asp His Asn Thr Lys 
    850                 855                 860                 


Thr Thr Thr Trp Glu Asp Pro Arg Leu Lys Ile Pro Ala His Leu Arg 
865                 870                 875                 880 


Gly Lys Thr Ser Leu Asp Thr Ser Asn Asp Leu Gly Pro Leu Pro Pro 
                885                 890                 895     


Gly Trp Glu Glu Arg Thr His Thr Asp Gly Arg Ile Phe Tyr Ile Asn 
            900                 905                 910         


His Asn Ile Lys Arg Thr Gln Trp Glu Asp Pro Arg Leu Glu Asn Val 
        915                 920                 925             


Ala Ile Thr Gly Pro Ala Val Pro Tyr Ser Arg Asp Tyr Lys Arg Lys 
    930                 935                 940                 


Tyr Glu Phe Phe Arg Arg Lys Leu Lys Lys Gln Asn Asp Ile Pro Asn 
945                 950                 955                 960 


Lys Phe Glu Met Lys Leu Arg Arg Ala Thr Val Leu Glu Asp Ser Tyr 
                965                 970                 975     


Arg Arg Ile Met Gly Val Lys Arg Ala Asp Phe Leu Lys Ala Arg Leu 
            980                 985                 990         


Trp Ile Glu Phe Asp Gly Glu Lys  Gly Leu Asp Tyr Gly  Gly Val Ala 
        995                 1000                 1005             


Arg Glu  Trp Phe Phe Leu Ile  Ser Lys Glu Met Phe  Asn Pro Tyr 
    1010                 1015                 1020             


Tyr Gly  Leu Phe Glu Tyr Ser  Ala Thr Asp Asn Tyr  Thr Leu Gln 
    1025                 1030                 1035             


Ile Asn  Pro Asn Ser Gly Leu  Cys Asn Glu Asp His  Leu Ser Tyr 
    1040                 1045                 1050             


Phe Lys  Phe Ile Gly Arg Val  Ala Gly Met Ala Val  Tyr His Gly 
    1055                 1060                 1065             


Lys Leu  Leu Asp Gly Phe Phe  Ile Arg Pro Phe Tyr  Lys Met Met 
    1070                 1075                 1080             


Leu His  Lys Pro Ile Thr Leu  His Asp Met Glu Ser  Val Asp Ser 
    1085                 1090                 1095             


Glu Tyr  Tyr Asn Ser Leu Arg  Trp Ile Leu Glu Asn  Asp Pro Thr 
    1100                 1105                 1110             


Glu Leu  Asp Leu Arg Phe Ile  Ile Asp Glu Glu Leu  Phe Gly Gln 
    1115                 1120                 1125             


Thr His  Gln His Glu Leu Lys  Asn Gly Gly Ser Glu  Ile Val Val 
    1130                 1135                 1140             


Thr Asn  Lys Asn Lys Lys Glu  Tyr Ile Tyr Leu Val  Ile Gln Trp 
    1145                 1150                 1155             


Arg Phe  Val Asn Arg Ile Gln  Lys Gln Met Ala Ala  Phe Lys Glu 
    1160                 1165                 1170             


Gly Phe  Phe Glu Leu Ile Pro  Gln Asp Leu Ile Lys  Ile Phe Asp 
    1175                 1180                 1185             


Glu Asn  Glu Leu Glu Leu Leu  Met Cys Gly Leu Gly  Asp Val Asp 
    1190                 1195                 1200             


Val Asn  Asp Trp Arg Glu His  Thr Lys Tyr Lys Asn  Gly Tyr Ser 
    1205                 1210                 1215             


Ala Asn  His Gln Val Ile Gln  Trp Phe Trp Lys Ala  Val Leu Met 
    1220                 1225                 1230             


Met Asp  Ser Glu Lys Arg Ile  Arg Leu Leu Gln Phe  Val Thr Gly 
    1235                 1240                 1245             


Thr Ser  Arg Val Pro Met Asn  Gly Phe Ala Glu Leu  Tyr Gly Ser 
    1250                 1255                 1260             


Asn Gly  Pro Gln Ser Phe Thr  Val Glu Gln Trp Gly  Thr Pro Glu 
    1265                 1270                 1275             


Lys Leu  Pro Arg Ala His Thr  Cys Phe Asn Arg Leu  Asp Leu Pro 
    1280                 1285                 1290             


Pro Tyr  Glu Ser Phe Glu Glu  Leu Trp Asp Lys Leu  Gln Met Ala 
    1295                 1300                 1305             


Ile Glu  Asn Thr Gln Gly Phe  Asp Gly Val Asp 
    1310                 1315                 


<210>  48
<211>  887
<212>  PRT
<213>  Mus musculus

<400>  48

Met Ser Ser Asp Met Ala Ala Asp Glu Ser Glu Ala Pro Val Leu Ser 
1               5                   10                  15      


Glu Asp Glu Val Trp Glu Phe Cys Leu Asp Lys Thr Glu Asp Gly Gly 
            20                  25                  30          


Gly Ser Pro Gly Ser Asp Val Thr Asp Thr Cys Glu Pro Pro Cys Gly 
        35                  40                  45              


Cys Trp Glu Leu Asn Pro Asn Ser Leu Glu Glu Glu His Val Leu Phe 
    50                  55                  60                  


Thr Ala Asp Pro Tyr Leu Glu Leu His Asn Asp Asp Thr Arg Val Val 
65                  70                  75                  80  


Arg Val Lys Val Ile Ala Gly Ile Gly Leu Ala Lys Lys Asp Ile Leu 
                85                  90                  95      


Gly Ala Ser Asp Pro Tyr Val Arg Val Thr Leu Tyr Asp Pro Met Ser 
            100                 105                 110         


Gly Ile Leu Thr Ser Val Gln Thr Lys Thr Ile Lys Lys Ser Leu Asn 
        115                 120                 125             


Pro Lys Trp Asn Glu Glu Ile Leu Phe Arg Val Leu Pro Gln Arg His 
    130                 135                 140                 


Arg Ile Leu Phe Glu Val Phe Asp Glu Asn Arg Leu Thr Arg Asp Asp 
145                 150                 155                 160 


Phe Leu Gly Gln Val Asp Val Pro Leu Tyr Pro Leu Pro Thr Glu Asn 
                165                 170                 175     


Pro Arg Met Glu Arg Pro Tyr Thr Phe Lys Asp Phe Val Leu His Pro 
            180                 185                 190         


Arg Ser His Lys Ser Arg Val Lys Gly Tyr Leu Arg Leu Lys Met Thr 
        195                 200                 205             


Tyr Leu Pro Lys Asn Gly Ser Glu Asp Glu Asn Ala Asp Gln Ala Glu 
    210                 215                 220                 


Glu Leu Glu Pro Gly Trp Val Val Leu Asp Gln Pro Asp Ala Ala Thr 
225                 230                 235                 240 


His Leu Pro His Pro Pro Glu Pro Ser Pro Leu Pro Pro Gly Trp Glu 
                245                 250                 255     


Glu Arg Gln Asp Val Leu Gly Arg Thr Tyr Tyr Val Asn His Glu Ser 
            260                 265                 270         


Arg Arg Thr Gln Trp Lys Arg Pro Ser Pro Asp Asp Asp Leu Thr Asp 
        275                 280                 285             


Glu Asp Asn Asp Asp Met Gln Leu Gln Ala Gln Arg Ala Phe Thr Thr 
    290                 295                 300                 


Arg Arg Gln Ile Ser Glu Asp Val Asp Gly Pro Asp Asn Arg Glu Ser 
305                 310                 315                 320 


Pro Glu Asn Trp Glu Ile Val Arg Glu Asp Glu Asn Thr Glu Tyr Ser 
                325                 330                 335     


Gly Gln Ala Val Gln Ser Pro Pro Ser Gly His Ile Asp Val Gln Thr 
            340                 345                 350         


His Leu Ala Glu Glu Phe Asn Thr Arg Leu Ala Val Cys Gly Asn Pro 
        355                 360                 365             


Ala Thr Ser Gln Pro Val Thr Ser Ser Asn His Ser Ser Arg Gly Gly 
    370                 375                 380                 


Ser Leu Gln Thr Cys Ile Phe Glu Glu Gln Pro Thr Leu Pro Val Leu 
385                 390                 395                 400 


Leu Pro Thr Ser Ser Gly Leu Pro Pro Gly Trp Glu Glu Lys Gln Asp 
                405                 410                 415     


Asp Arg Gly Arg Ser Tyr Tyr Val Asp His Asn Ser Lys Thr Thr Thr 
            420                 425                 430         


Trp Ser Lys Pro Thr Met Gln Asp Asp Pro Arg Ser Lys Ile Pro Ala 
        435                 440                 445             


His Leu Arg Gly Lys Thr Asp Ser Asn Asp Leu Gly Pro Leu Pro Pro 
    450                 455                 460                 


Gly Trp Glu Glu Arg Thr His Thr Asp Gly Arg Val Phe Phe Ile Asn 
465                 470                 475                 480 


His Asn Ile Lys Lys Thr Gln Trp Glu Asp Pro Arg Leu Gln Asn Val 
                485                 490                 495     


Ala Ile Thr Gly Pro Ala Val Pro Tyr Ser Arg Asp Tyr Lys Arg Lys 
            500                 505                 510         


Tyr Glu Phe Phe Arg Arg Lys Leu Lys Lys Gln Thr Asp Ile Pro Asn 
        515                 520                 525             


Lys Phe Glu Met Lys Leu Arg Arg Ala Asn Ile Leu Glu Asp Ser Tyr 
    530                 535                 540                 


Arg Arg Ile Met Gly Val Lys Arg Ala Asp Leu Leu Lys Ala Arg Leu 
545                 550                 555                 560 


Trp Ile Glu Phe Asp Gly Glu Lys Gly Leu Asp Tyr Gly Gly Val Ala 
                565                 570                 575     


Arg Glu Trp Phe Phe Leu Ile Ser Lys Glu Met Phe Asn Pro Tyr Tyr 
            580                 585                 590         


Gly Leu Phe Glu Tyr Ser Ala Thr Asp Asn Tyr Thr Leu Gln Ile Asn 
        595                 600                 605             


Pro Asn Ser Gly Leu Cys Asn Glu Asp His Leu Ser Tyr Phe Lys Phe 
    610                 615                 620                 


Ile Gly Arg Val Ala Gly Met Ala Val Tyr His Gly Lys Leu Leu Asp 
625                 630                 635                 640 


Gly Phe Phe Ile Arg Pro Phe Tyr Lys Met Met Leu Gln Lys Leu Ile 
                645                 650                 655     


Thr Leu His Asp Met Glu Ser Val Asp Ser Glu Tyr Tyr Ser Ser Leu 
            660                 665                 670         


Arg Trp Ile Leu Glu Asn Asp Pro Thr Glu Leu Asp Leu Arg Phe Ile 
        675                 680                 685             


Ile Asp Glu Glu Leu Phe Gly Gln Thr His Gln His Glu Leu Lys Thr 
    690                 695                 700                 


Gly Gly Ser Glu Ile Val Val Thr Asn Lys Asn Lys Lys Glu Tyr Ile 
705                 710                 715                 720 


Tyr Leu Val Ile Gln Trp Arg Phe Val Asn Arg Ile Gln Lys Gln Met 
                725                 730                 735     


Ala Ala Phe Lys Glu Gly Phe Phe Glu Leu Ile Pro Gln Asp Leu Ile 
            740                 745                 750         


Lys Ile Phe Asp Glu Asn Glu Leu Glu Leu Leu Met Cys Gly Leu Gly 
        755                 760                 765             


Asp Val Asp Val Asn Asp Trp Arg Glu His Thr Lys Tyr Lys Asn Gly 
    770                 775                 780                 


Tyr Ser Met Asn His Gln Val Ile His Trp Phe Trp Lys Ala Val Trp 
785                 790                 795                 800 


Met Met Asp Ser Glu Lys Arg Ile Arg Leu Leu Gln Phe Val Thr Gly 
                805                 810                 815     


Thr Ser Arg Val Pro Met Asn Gly Phe Ala Glu Leu Tyr Gly Ser Asn 
            820                 825                 830         


Gly Pro Gln Ser Phe Thr Val Glu Gln Trp Gly Thr Pro Asp Lys Leu 
        835                 840                 845             


Pro Arg Ala His Thr Cys Phe Asn Arg Leu Asp Leu Pro Pro Tyr Glu 
    850                 855                 860                 


Ser Phe Asp Glu Leu Trp Asp Lys Leu Gln Met Ala Ile Glu Asn Thr 
865                 870                 875                 880 


Gln Gly Phe Asp Gly Val Asp 
                885         


<210>  49
<211>  324
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ser Arg Pro Ser Ser Thr Gly Pro Ser Ala Asn Lys Pro Cys Ser 
1               5                   10                  15      


Lys Gln Pro Pro Pro Gln Pro Gln His Thr Pro Ser Pro Ala Ala Pro 
            20                  25                  30          


Pro Ala Ala Ala Thr Ile Ser Ala Ala Gly Pro Gly Ser Ser Ala Val 
        35                  40                  45              


Pro Ala Ala Ala Ala Val Ile Ser Gly Pro Gly Gly Gly Gly Gly Ala 
    50                  55                  60                  


Gly Pro Val Ser Pro Gln His His Glu Leu Thr Ser Leu Phe Glu Cys 
65                  70                  75                  80  


Pro Val Cys Phe Asp Tyr Val Leu Pro Pro Ile Leu Gln Cys Gln Ala 
                85                  90                  95      


Gly His Leu Val Cys Asn Gln Cys Arg Gln Lys Leu Ser Cys Cys Pro 
            100                 105                 110         


Thr Cys Arg Gly Ala Leu Thr Pro Ser Ile Arg Asn Leu Ala Met Glu 
        115                 120                 125             


Lys Val Ala Ser Ala Val Leu Phe Pro Cys Lys Tyr Ala Thr Thr Gly 
    130                 135                 140                 


Cys Ser Leu Thr Leu His His Thr Glu Lys Pro Glu His Glu Asp Ile 
145                 150                 155                 160 


Cys Glu Tyr Arg Pro Tyr Ser Cys Pro Cys Pro Gly Ala Ser Cys Lys 
                165                 170                 175     


Trp Gln Gly Ser Leu Glu Ala Val Met Ser His Leu Met His Ala His 
            180                 185                 190         


Lys Ser Ile Thr Thr Leu Gln Gly Glu Asp Ile Val Phe Leu Ala Thr 
        195                 200                 205             


Asp Ile Asn Leu Pro Gly Ala Val Asp Trp Val Met Met Gln Ser Cys 
    210                 215                 220                 


Phe Gly His His Phe Met Leu Val Leu Glu Lys Gln Glu Lys Tyr Glu 
225                 230                 235                 240 


Gly His Gln Gln Phe Phe Ala Ile Val Leu Leu Ile Gly Thr Arg Lys 
                245                 250                 255     


Gln Ala Glu Asn Phe Ala Tyr Arg Leu Glu Leu Asn Gly Asn Arg Arg 
            260                 265                 270         


Arg Leu Thr Trp Glu Ala Thr Pro Arg Ser Ile His Asp Gly Val Ala 
        275                 280                 285             


Ala Ala Ile Met Asn Ser Asp Cys Leu Val Phe Asp Thr Ala Ile Ala 
    290                 295                 300                 


His Leu Phe Ala Asp Asn Gly Asn Leu Gly Ile Asn Val Thr Ile Ser 
305                 310                 315                 320 


Thr Cys Cys Pro 
                


<210>  50
<211>  301
<212>  PRT
<213>  Arabidopsis thaliana

<400>  50

Met Ala Phe Asn His Arg Lys Met Leu Leu Ser Cys Leu Gln Phe Lys 
1               5                   10                  15      


Asp Leu Arg Phe Cys Phe Arg Gln Tyr Pro Pro Pro Pro Pro Pro Pro 
            20                  25                  30          


Pro Pro Pro Arg Glu Leu Ser Leu Leu Leu Pro Thr Ser Ile Cys Val 
        35                  40                  45              


Val Gly Ser Ile Ile Leu Phe Leu Phe Leu Val Phe Phe Leu Tyr Leu 
    50                  55                  60                  


His Ile Thr Gln Gln Arg Arg Ile Ser Ala Ala Ser Val Thr Pro Gly 
65                  70                  75                  80  


Asp Thr Asn Gln Gln Glu Asp Glu Asp Glu Thr Glu Glu Arg Asp Phe 
                85                  90                  95      


Ser Asp Phe His His Val Trp Gln Ile Pro Thr Val Gly Leu His Arg 
            100                 105                 110         


Ser Ala Ile Asn Ser Ile Thr Val Val Gly Phe Lys Lys Gly Glu Gly 
        115                 120                 125             


Ile Ile Asp Gly Thr Glu Cys Ser Val Cys Leu Asn Glu Phe Glu Glu 
    130                 135                 140                 


Asp Glu Ser Leu Arg Leu Leu Pro Lys Cys Ser His Ala Phe His Leu 
145                 150                 155                 160 


Asn Cys Ile Asp Thr Trp Leu Leu Ser His Lys Asn Cys Pro Leu Cys 
                165                 170                 175     


Arg Ala Pro Val Leu Leu Ile Thr Glu Pro Pro His Gln Glu Thr Glu 
            180                 185                 190         


Thr Asn His Gln Pro Asp Ser Glu Ser Ser Asn Asp Leu Arg Gly Arg 
        195                 200                 205             


Gln Asp Ser Ser Arg Ser Arg Arg Asn His Asn Ile Phe Leu Pro Arg 
    210                 215                 220                 


Ala Gln Ser Asp Leu Ala Asn Tyr Cys Gly Ser Gly Arg Val Glu Asn 
225                 230                 235                 240 


Val Arg Arg Ser Phe Ser Ile Gly Gly Ser Leu Ser Leu Cys Asp Gly 
                245                 250                 255     


Ile Asn Asn Ala Thr Arg Ser Gly Arg Gln Phe Tyr Thr Ser Phe Ser 
            260                 265                 270         


Ala Asn Leu Phe Ser Ser Ser Arg Arg Val Arg Asn Glu Gln Pro Ile 
        275                 280                 285             


Pro Gln Asn Gln Met Pro Ser Val Thr Gly Asn Thr Ser 
    290                 295                 300     


<210>  51
<211>  1030
<212>  PRT
<213>  Danio rerio

<400>  51

Met Thr Thr Gly Arg Asn Asn Arg Val Met Met Glu Gly Val Gly Ala 
1               5                   10                  15      


Arg Val Ile Arg Gly Pro Asp Trp Lys Trp Gly Lys Gln Asp Gly Gly 
            20                  25                  30          


Glu Gly His Val Gly Thr Val Arg Ser Phe Glu Ser Pro Glu Glu Val 
        35                  40                  45              


Val Val Val Trp Asp Asn Gly Thr Ala Ala Asn Tyr Arg Cys Ser Gly 
    50                  55                  60                  


Ala Tyr Asp Val Arg Ile Leu Asp Ser Ala Pro Thr Gly Ile Lys His 
65                  70                  75                  80  


Asp Gly Thr Met Cys Asp Thr Cys Arg Gln Gln Pro Ile Ile Gly Ile 
                85                  90                  95      


Arg Trp Lys Cys Ala Glu Cys Thr Asn Tyr Asp Leu Cys Thr Thr Cys 
            100                 105                 110         


Tyr His Gly Asp Lys His His Leu Arg His Arg Phe Tyr Arg Ile Thr 
        115                 120                 125             


Thr Pro Gly Ser Glu Arg Val Leu Leu Glu Ser Arg Arg Lys Ser Lys 
    130                 135                 140                 


Lys Ile Thr Ala Arg Gly Ile Phe Ala Gly Gly Arg Val Val Arg Gly 
145                 150                 155                 160 


Val Asp Trp Gln Trp Glu Asp Gln Asp Gly Gly Asn Gly Arg Arg Gly 
                165                 170                 175     


Lys Val Thr Glu Ile Gln Asp Trp Ser Ala Ala Ser Pro His Ser Ala 
            180                 185                 190         


Ala Tyr Val Leu Trp Asp Asn Gly Ala Lys Asn Leu Tyr Arg Val Gly 
        195                 200                 205             


Phe Glu Gly Met Ser Asp Leu Lys Cys Val Gln Asp Ala Lys Gly Gly 
    210                 215                 220                 


Thr Phe Tyr Arg Asp His Cys Pro Val Leu Gly Glu Gln Asn Gly Asn 
225                 230                 235                 240 


Arg Asn Pro Gly Gly Leu Gln Ile Gly Asp Leu Val Asn Ile Asp Leu 
                245                 250                 255     


Asp Leu Glu Ile Val Gln Ser Leu Gln His Gly His Gly Gly Trp Thr 
            260                 265                 270         


Asp Gly Met Phe Glu Thr Leu Thr Thr Thr Gly Thr Val Cys Gly Ile 
        275                 280                 285             


Asp Glu Asp His Asp Ile Val Val Gln Tyr Pro Ser Gly Asn Arg Trp 
    290                 295                 300                 


Thr Phe Asn Pro Ala Val Leu Thr Lys Ala Asn Val Val Arg Ser Gly 
305                 310                 315                 320 


Glu Val Ala Ala Gly Ala Glu Gly Gly Ser Ser Gln Phe Met Val Gly 
                325                 330                 335     


Asp Leu Val Gln Ile Cys Tyr Asp Ile Asp Arg Ile Lys Leu Leu Gln 
            340                 345                 350         


Arg Gly His Gly Glu Trp Ala Glu Ala Met Leu Pro Thr Leu Gly Lys 
        355                 360                 365             


Val Gly Arg Val Gln Gln Ile Tyr Ser Asp Ser Asp Leu Lys Val Glu 
    370                 375                 380                 


Val Cys Gly Thr Ser Trp Thr Tyr Asn Pro Ala Ala Val Thr Lys Val 
385                 390                 395                 400 


Ala Pro Ala Gly Ser Ala Val Thr Asn Ala Ser Gly Glu Arg Leu Ser 
                405                 410                 415     


Gln Leu Leu Lys Lys Leu Phe Glu Thr Gln Glu Ser Gly Asp Ile Asn 
            420                 425                 430         


Glu Glu Leu Val Lys Ala Ala Ala Asn Gly Asp Leu Ala Lys Val Glu 
        435                 440                 445             


Asp Ile Leu Lys Arg Pro Asp Val Asp Val Asn Gly Gln Cys Ala Gly 
    450                 455                 460                 


His Thr Ala Met Gln Ala Ala Ser Gln Asn Gly His Val Asp Val Leu 
465                 470                 475                 480 


Lys Leu Leu Leu Lys His Ser Val Asp Leu Glu Ala Glu Asp Lys Asp 
                485                 490                 495     


Gly Asp Arg Ala Val His His Ala Ser Phe Gly Asp Glu Gly Ser Val 
            500                 505                 510         


Ile Glu Val Leu His Arg Gly Gly Ala Asp Leu Asn Ala Arg Asn Lys 
        515                 520                 525             


Arg Arg Gln Thr Pro Leu His Ile Ala Val Asn Lys Gly His Leu Gln 
    530                 535                 540                 


Val Val Lys Thr Leu Leu Asp Phe Gly Cys His Pro Ser Leu Gln Asp 
545                 550                 555                 560 


Ser Glu Gly Asp Thr Pro Leu His Asp Ala Ile Ser Lys Lys Arg Asp 
                565                 570                 575     


Asp Met Leu Ser Val Leu Leu Glu Ala Gly Ala Asp Val Thr Ile Thr 
            580                 585                 590         


Asn Asn Asn Gly Phe Asn Ala Leu His His Ala Ala Leu Arg Gly Asn 
        595                 600                 605             


Pro Ser Ala Met Arg Val Leu Leu Ser Lys Leu Pro Arg Pro Trp Ile 
    610                 615                 620                 


Val Asp Glu Lys Lys Asp Asp Gly Tyr Thr Ala Leu His Leu Ala Ala 
625                 630                 635                 640 


Leu Asn Asn His Val Glu Val Ala Glu Leu Leu Val His Gln Gly Asn 
                645                 650                 655     


Ala Asn Leu Asp Val Gln Asn Val Asn Gln Gln Thr Ala Leu His Leu 
            660                 665                 670         


Ala Val Glu Arg Gln His Thr Gln Ile Val Arg Leu Leu Val Arg Ala 
        675                 680                 685             


Glu Ala Lys Leu Asp Val Gln Asp Lys Asp Gly Asp Thr Pro Leu His 
    690                 695                 700                 


Glu Ala Leu Arg His His Thr Leu Ser Gln Leu Arg Gln Leu Gln Asp 
705                 710                 715                 720 


Met Gln Asp Val Ser Lys Val Glu Pro Trp Glu Pro Ser Lys Asn Thr 
                725                 730                 735     


Leu Ile Met Gly Leu Gly Thr Gln Gly Ala Glu Lys Lys Ser Ala Ala 
            740                 745                 750         


Ser Ile Ala Cys Phe Leu Ala Ala Asn Gly Ala Asp Leu Thr Ile Arg 
        755                 760                 765             


Asn Lys Lys Gly Gln Ser Pro Leu Asp Leu Cys Pro Asp Pro Ser Leu 
    770                 775                 780                 


Cys Lys Ala Leu Ala Lys Cys His Lys Glu Lys Thr Ser Gly Gln Val 
785                 790                 795                 800 


Gly Ser Arg Ser Pro Ser Leu Asn Ser Asn Asn Glu Thr Leu Glu Glu 
                805                 810                 815     


Cys Met Val Cys Ser Asp Met Lys Arg Asp Thr Leu Phe Gly Pro Cys 
            820                 825                 830         


Gly His Ile Ala Thr Cys Ser Leu Cys Ser Pro Arg Val Lys Lys Cys 
        835                 840                 845             


Leu Ile Cys Lys Glu Gln Val Gln Ser Arg Thr Lys Ile Glu Glu Cys 
    850                 855                 860                 


Val Val Cys Ser Asp Lys Lys Ala Ala Val Leu Phe Gln Pro Cys Gly 
865                 870                 875                 880 


His Met Cys Ala Cys Glu Asn Cys Ala Ser Leu Met Lys Lys Cys Val 
                885                 890                 895     


Gln Cys Arg Ala Val Val Glu Arg Arg Thr Pro Phe Val Leu Cys Cys 
            900                 905                 910         


Gly Gly Lys Gly Met Glu Asp Ala Thr Asp Asp Glu Asp Leu Thr Gly 
        915                 920                 925             


Gly Ser Asn Ser Met Ala Gly Gly Ser Gln Asp Leu Leu Gln Pro Asn 
    930                 935                 940                 


Asn Leu Ala Leu Ser Trp Ser Ser Gly Asn Ile Pro Ala Leu Gln Arg 
945                 950                 955                 960 


Asp Lys Asp Asn Thr Asn Val Asn Ala Asp Val Gln Lys Leu Gln Gln 
                965                 970                 975     


Gln Leu Gln Asp Ile Lys Glu Gln Thr Met Cys Pro Val Cys Leu Asp 
            980                 985                 990         


Arg Leu Lys Asn Met Ile Phe Met  Cys Gly His Gly Thr  Cys Gln Leu 
        995                 1000                 1005             


Cys Gly  Asp Arg Met Ser Glu  Cys Pro Ile Cys Arg  Lys Ala Ile 
    1010                 1015                 1020             


Glu Arg  Arg Ile Leu Leu Tyr  
    1025                 1030 


<210>  52
<211>  522
<212>  PRT
<213>  Arabidopsis thaliana

<400>  52

Met Ser Val Lys Asn Asn Ser Phe Ser Ser Ala Glu Ile Pro Asp Val 
1               5                   10                  15      


Ala Asp Gln Pro Arg Asp Arg Phe Asn Pro Glu Ala Thr Gln Asp Leu 
            20                  25                  30          


Gln Glu Lys Asp Glu Thr Lys Glu Glu Lys Glu Gly Asp Glu Glu Val 
        35                  40                  45              


Lys His Asp Glu Ala Glu Glu Asp Gln Glu Val Val Lys Pro Asn Asp 
    50                  55                  60                  


Ala Glu Glu Asp Asp Asp Gly Asp Asp Ala Glu Glu Asp Glu Glu Glu 
65                  70                  75                  80  


Glu Val Glu Ala Glu Glu Asp Glu Glu Ala Glu Glu Glu Glu Glu Glu 
                85                  90                  95      


Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Ser Lys Glu Arg Ser Pro 
            100                 105                 110         


Ser Ser Ile Ser Gly Asp Gln Ser Glu Phe Met Glu Ile Asp Leu Gly 
        115                 120                 125             


Glu Ile Arg Lys Asp Val Gln Cys Pro Ile Cys Leu Gly Ile Ile Lys 
    130                 135                 140                 


Lys Thr Arg Thr Val Met Glu Cys Leu His Arg Phe Cys Arg Glu Cys 
145                 150                 155                 160 


Ile Asp Lys Ser Met Arg Leu Gly Asn Asn Glu Cys Pro Ala Cys Arg 
                165                 170                 175     


Lys His Cys Ala Ser Arg Arg Ser Leu Arg Asp Asp Pro Lys Phe Asp 
            180                 185                 190         


Ala Leu Ile Ala Ala Leu Phe Thr Asn Ile Asp Ser Tyr Glu Glu Glu 
        195                 200                 205             


Glu Leu Ala Phe His Glu Asp Glu Met Ala Arg Asn Lys Gln Ile Gln 
    210                 215                 220                 


Ala Ser Ile Ala Gln Ile Ser Gln Arg Gln Ser Glu Ala Leu Val Lys 
225                 230                 235                 240 


Arg Arg Ser Leu Gly Lys Glu Ala Ala Val Leu Met Arg Ser Pro Arg 
                245                 250                 255     


Ile Ala Ser Gly Ser Arg Arg Arg Arg Asn Ser Arg Asn Met Glu Gln 
            260                 265                 270         


Gln Asn Ala Ser Glu Ala His Glu Asp Asp Asp Asn Asp Asp Asn Asn 
        275                 280                 285             


Asn Arg Gly Arg Asp Lys Asp Ser Ser Ser Asp Glu Arg Gly Thr Glu 
    290                 295                 300                 


Val Arg Gln Lys Lys Arg Arg Lys Arg Ser Thr Ser Arg Ser Thr Gln 
305                 310                 315                 320 


His Pro Ser Ser Ser Gly Ala Asn Lys Asn Asn Gly Asn Cys Ala Asp 
                325                 330                 335     


Asn Asp Thr Glu Val Tyr Arg Asp Thr Lys Gly Ile Ser Pro Gly Leu 
            340                 345                 350         


Val Trp Asn Pro Glu Ile Leu Ala Trp Gly Arg Gly Gly Thr Arg Ser 
        355                 360                 365             


Asn Thr Arg His Gly Asn Asn Thr Ser Gly Gly Ser Ser Lys Ser Val 
    370                 375                 380                 


Arg Asn Ala Arg Val Asn Lys Leu Val Glu Tyr Leu Arg Ser Ser Val 
385                 390                 395                 400 


Asp Gly Ser Ser Val Glu Leu Asp Ile His Val Lys Leu Val Ser Leu 
                405                 410                 415     


Asp Thr Lys Cys Ile Pro Asp Leu Pro Gln Pro Tyr Leu Cys Cys Arg 
            420                 425                 430         


Pro Thr Leu Leu Val Lys Gln Leu Arg Glu Phe Val Ala Leu Gln Ile 
        435                 440                 445             


His Leu Lys Thr Glu Glu Val Glu Leu Leu Val Thr Arg Arg Arg Val 
    450                 455                 460                 


Gly Glu Asp Ala Ala Ile Glu Asn Leu Pro Ala Val Thr Pro Ala Ser 
465                 470                 475                 480 


Ala Ala Ala Ser Lys Asp Glu Met Leu Ser Leu Glu Asp Asn Glu Thr 
                485                 490                 495     


Leu Ser Arg Leu Lys Ile Asp Phe Ile Ser Ser His Glu Gln His Leu 
            500                 505                 510         


Ile Ile Ala Tyr Arg Lys Lys Gln Thr Glu 
        515                 520         


<210>  53
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Thr Leu Val Val Asn Lys Leu Gly Ala Gly Val Asp Ser Gly 
1               5                   10                  15      


Arg Gln Gly Ser Arg Gly Thr Ala Val Val Lys Val Leu Glu Cys Gly 
            20                  25                  30          


Val Cys Glu Asp Val Phe Ser Leu Gln Gly Asp Lys Val Pro Arg Leu 
        35                  40                  45              


Leu Leu Cys Gly His Thr Val Cys His Asp Cys Leu Thr Arg Leu Pro 
    50                  55                  60                  


Leu His Gly Arg Ala Ile Arg Cys Pro Phe Asp Arg Gln Val Thr Asp 
65                  70                  75                  80  


Leu Gly Asp Ser Gly Val Trp Gly Leu Lys Lys Asn Phe Ala Leu Leu 
                85                  90                  95      


Glu Leu Leu Glu Arg Leu Gln Asn Gly Pro Ile Gly Gln Tyr Gly Ala 
            100                 105                 110         


Ala Glu Glu Ser Ile Gly Ile Ser Gly Glu Ser Ile Ile Arg Cys Asp 
        115                 120                 125             


Glu Asp Glu Ala His Leu Ala Ser Val Tyr Cys Thr Val Cys Ala Thr 
    130                 135                 140                 


His Leu Cys Ser Glu Cys Ser Gln Val Thr His Ser Thr Lys Thr Leu 
145                 150                 155                 160 


Ala Lys His Arg Arg Val Pro Leu Ala Asp Lys Pro His Glu Lys Thr 
                165                 170                 175     


Met Cys Ser Gln His Gln Val His Ala Ile Glu Phe Val Cys Leu Glu 
            180                 185                 190         


Glu Gly Cys Gln Thr Ser Pro Leu Met Cys Cys Val Cys Lys Glu Tyr 
        195                 200                 205             


Gly Lys His Gln Gly His Lys His Ser Val Leu Glu Pro Glu Ala Asn 
    210                 215                 220                 


Gln Ile Arg Ala Ser Ile Leu Asp Met Ala His Cys Ile Arg Thr Phe 
225                 230                 235                 240 


Thr Glu Glu Ile Ser Asp Tyr Ser Arg Lys Leu Val Gly Ile Val Gln 
                245                 250                 255     


His Ile Glu Gly Gly Glu Gln Ile Val Glu Asp Gly Ile Gly Met Ala 
            260                 265                 270         


His Thr Glu His Val Pro Gly Thr Ala Glu Asn Ala Arg Ser Cys Ile 
        275                 280                 285             


Arg Ala Tyr Phe Tyr Asp Leu His Glu Thr Leu Cys Arg Gln Glu Glu 
    290                 295                 300                 


Met Ala Leu Ser Val Val Asp Ala His Val Arg Glu Lys Leu Ile Trp 
305                 310                 315                 320 


Leu Arg Gln Gln Gln Glu Asp Met Thr Ile Leu Leu Ser Glu Val Ser 
                325                 330                 335     


Ala Ala Cys Leu His Cys Glu Lys Thr Leu Gln Gln Asp Asp Cys Arg 
            340                 345                 350         


Val Val Leu Ala Lys Gln Glu Ile Thr Arg Leu Leu Glu Thr Leu Gln 
        355                 360                 365             


Lys Gln Gln Gln Gln Phe Thr Glu Val Ala Asp His Ile Gln Leu Asp 
    370                 375                 380                 


Ala Ser Ile Pro Val Thr Phe Thr Lys Asp Asn Arg Val His Ile Gly 
385                 390                 395                 400 


Pro Lys Met Glu Ile Arg Val Val Thr Leu Gly Leu Asp Gly Ala Gly 
                405                 410                 415     


Lys Thr Thr Ile Leu Phe Lys Leu Lys Gln Asp Glu Phe Met Gln Pro 
            420                 425                 430         


Ile Pro Thr Ile Gly Phe Asn Val Glu Thr Val Glu Tyr Lys Asn Leu 
        435                 440                 445             


Lys Phe Thr Ile Trp Asp Val Gly Gly Lys His Lys Leu Arg Pro Leu 
    450                 455                 460                 


Trp Lys His Tyr Tyr Leu Asn Thr Gln Ala Val Val Phe Val Val Asp 
465                 470                 475                 480 


Ser Ser His Arg Asp Arg Ile Ser Glu Ala His Ser Glu Leu Ala Lys 
                485                 490                 495     


Leu Leu Thr Glu Lys Glu Leu Arg Asp Ala Leu Leu Leu Ile Phe Ala 
            500                 505                 510         


Asn Lys Gln Asp Val Ala Gly Ala Leu Ser Val Glu Glu Ile Thr Glu 
        515                 520                 525             


Leu Leu Ser Leu His Lys Leu Cys Cys Gly Arg Ser Trp Tyr Ile Gln 
    530                 535                 540                 


Gly Cys Asp Ala Arg Ser Gly Met Gly Leu Tyr Glu Gly Leu Asp Trp 
545                 550                 555                 560 


Leu Ser Arg Gln Leu Val Ala Ala Gly Val Leu Asp Val Ala 
                565                 570                 


<210>  54
<211>  864
<212>  PRT
<213>  Mus musculus

<400>  54

Met Ser Asp Ser Gly Pro Gln Leu Asp Ser Met Gly Ser Leu Thr Met 
1               5                   10                  15      


Lys Ser Gln Leu Gln Ile Thr Val Ile Ser Ala Lys Leu Lys Glu Asn 
            20                  25                  30          


Lys Lys Asn Trp Phe Gly Pro Ser Pro Tyr Val Glu Val Thr Val Asp 
        35                  40                  45              


Gly Gln Ser Lys Lys Thr Glu Lys Cys Asn Asn Thr Asn Ser Pro Lys 
    50                  55                  60                  


Trp Lys Gln Pro Leu Thr Val Ile Val Thr Pro Thr Ser Lys Leu Cys 
65                  70                  75                  80  


Phe Arg Val Trp Ser His Gln Thr Leu Lys Ser Asp Val Leu Leu Gly 
                85                  90                  95      


Thr Ala Gly Leu Asp Ile Tyr Glu Thr Leu Lys Ser Asn Asn Met Lys 
            100                 105                 110         


Leu Glu Glu Val Val Met Thr Leu Gln Leu Val Gly Asp Lys Glu Pro 
        115                 120                 125             


Thr Glu Thr Met Gly Asp Leu Ser Val Cys Leu Asp Gly Leu Gln Val 
    130                 135                 140                 


Glu Ala Glu Val Val Thr Asn Gly Glu Thr Ser Cys Ser Glu Ser Thr 
145                 150                 155                 160 


Thr Gln Asn Asp Asp Gly Cys Arg Thr Arg Asp Asp Thr Arg Val Ser 
                165                 170                 175     


Thr Asn Gly Ser Glu Asp Pro Glu Val Ala Ala Ser Gly Glu Asn Lys 
            180                 185                 190         


Arg Ala Asn Gly Asn Asn Ser Pro Ser Leu Ser Asn Gly Gly Phe Lys 
        195                 200                 205             


Pro Ser Arg Pro Pro Arg Pro Ser Arg Pro Pro Pro Pro Thr Pro Arg 
    210                 215                 220                 


Arg Pro Ala Ser Val Asn Gly Ser Pro Ser Thr Asn Ser Asp Ser Asp 
225                 230                 235                 240 


Gly Ser Ser Thr Gly Ser Leu Pro Pro Thr Asn Thr Asn Val Asn Thr 
                245                 250                 255     


Ser Thr Ser Glu Gly Ala Thr Ser Gly Leu Ile Ile Pro Leu Thr Ile 
            260                 265                 270         


Ser Gly Gly Ser Gly Pro Arg Pro Leu Asn Thr Val Ser Gln Ala Pro 
        275                 280                 285             


Leu Pro Pro Gly Trp Glu Gln Arg Val Asp Gln His Gly Arg Val Tyr 
    290                 295                 300                 


Tyr Val Asp His Val Glu Lys Arg Thr Thr Trp Asp Arg Pro Glu Pro 
305                 310                 315                 320 


Leu Pro Pro Gly Trp Glu Arg Arg Val Asp Asn Met Gly Arg Ile Tyr 
                325                 330                 335     


Tyr Val Asp His Phe Thr Arg Thr Thr Thr Trp Gln Arg Pro Thr Leu 
            340                 345                 350         


Glu Ser Val Arg Asn Tyr Glu Gln Trp Gln Leu Gln Arg Ser Gln Leu 
        355                 360                 365             


Gln Gly Ala Met Gln Gln Phe Asn Gln Arg Phe Ile Tyr Gly Asn Gln 
    370                 375                 380                 


Asp Leu Phe Ala Thr Ser Gln Asn Lys Glu Phe Asp Pro Leu Gly Pro 
385                 390                 395                 400 


Leu Pro Pro Gly Trp Glu Lys Arg Thr Asp Ser Asn Gly Arg Val Tyr 
                405                 410                 415     


Phe Val Asn His Asn Thr Arg Ile Thr Gln Trp Glu Asp Pro Arg Ser 
            420                 425                 430         


Gln Gly Gln Leu Asn Glu Lys Pro Leu Pro Glu Gly Trp Glu Met Arg 
        435                 440                 445             


Phe Thr Val Asp Gly Ile Pro Tyr Phe Val Asp His Asn Arg Arg Ala 
    450                 455                 460                 


Thr Thr Tyr Ile Asp Pro Arg Thr Gly Lys Ser Ala Leu Asp Asn Gly 
465                 470                 475                 480 


Pro Gln Ile Ala Tyr Val Arg Asp Phe Lys Ala Lys Val Gln Tyr Phe 
                485                 490                 495     


Arg Phe Trp Cys Gln Gln Leu Ala Met Pro Gln His Ile Lys Ile Thr 
            500                 505                 510         


Val Thr Arg Lys Thr Leu Phe Glu Asp Ser Phe Gln Gln Ile Met Ser 
        515                 520                 525             


Phe Ser Pro Gln Asp Leu Arg Arg Arg Leu Trp Val Ile Phe Pro Gly 
    530                 535                 540                 


Glu Glu Gly Leu Asp Tyr Gly Gly Val Ala Arg Glu Trp Phe Phe Leu 
545                 550                 555                 560 


Leu Ser His Glu Val Leu Asn Pro Met Tyr Cys Leu Phe Glu Tyr Ala 
                565                 570                 575     


Gly Lys Asp Asn Tyr Cys Leu Gln Ile Asn Pro Ala Ser Tyr Ile Asn 
            580                 585                 590         


Pro Asp His Leu Lys Tyr Phe Arg Phe Ile Gly Arg Phe Ile Ala Met 
        595                 600                 605             


Ala Leu Phe His Gly Lys Phe Ile Asp Thr Gly Phe Ser Leu Pro Phe 
    610                 615                 620                 


Tyr Lys Arg Ile Leu Asn Lys Pro Val Gly Leu Lys Asp Leu Glu Ser 
625                 630                 635                 640 


Ile Asp Pro Glu Phe Tyr Asn Ser Leu Ile Trp Val Lys Glu Asn Asn 
                645                 650                 655     


Ile Glu Glu Cys Gly Leu Glu Met Tyr Phe Ser Val Asp Lys Glu Ile 
            660                 665                 670         


Leu Gly Glu Ile Lys Ser His Asp Leu Lys Pro Asn Gly Gly Asn Ile 
        675                 680                 685             


Leu Val Thr Glu Glu Asn Lys Glu Glu Tyr Ile Arg Met Val Ala Glu 
    690                 695                 700                 


Trp Arg Leu Ser Arg Gly Val Glu Glu Gln Thr Gln Ala Phe Phe Glu 
705                 710                 715                 720 


Gly Phe Asn Glu Ile Leu Pro Gln Gln Tyr Leu Gln Tyr Phe Asp Ala 
                725                 730                 735     


Lys Glu Leu Glu Val Leu Leu Cys Gly Met Gln Glu Ile Asp Leu Asn 
            740                 745                 750         


Asp Trp Gln Arg His Ala Ile Tyr Arg His Tyr Thr Arg Thr Ser Lys 
        755                 760                 765             


Gln Ile Met Trp Phe Trp Gln Phe Val Lys Glu Ile Asp Asn Glu Lys 
    770                 775                 780                 


Arg Met Arg Leu Leu Gln Phe Val Thr Gly Thr Cys Arg Leu Pro Val 
785                 790                 795                 800 


Gly Gly Phe Ala Asp Leu Met Gly Ser Asn Gly Pro Gln Lys Phe Cys 
                805                 810                 815     


Ile Glu Lys Val Gly Lys Glu Asn Trp Leu Pro Arg Ser His Thr Cys 
            820                 825                 830         


Phe Asn Arg Leu Asp Leu Pro Pro Tyr Lys Ser Tyr Glu Gln Leu Lys 
        835                 840                 845             


Glu Lys Leu Leu Phe Ala Ile Glu Glu Thr Glu Gly Phe Gly Gln Glu 
    850                 855                 860                 


<210>  55
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Asp Tyr Lys Ser Ser Leu Ile Gln Asp Gly Asn Pro Met Glu Asn 
1               5                   10                  15      


Leu Glu Lys Gln Leu Ile Cys Pro Ile Cys Leu Glu Met Phe Thr Lys 
            20                  25                  30          


Pro Val Val Ile Leu Pro Cys Gln His Asn Leu Cys Arg Lys Cys Ala 
        35                  40                  45              


Asn Asp Ile Phe Gln Ala Ala Asn Pro Tyr Trp Thr Ser Arg Gly Ser 
    50                  55                  60                  


Ser Val Ser Met Ser Gly Gly Arg Phe Arg Cys Pro Thr Cys Arg His 
65                  70                  75                  80  


Glu Val Ile Met Asp Arg His Gly Val Tyr Gly Leu Gln Arg Asn Leu 
                85                  90                  95      


Leu Val Glu Asn Ile Ile Asp Ile Tyr Lys Gln Glu Cys Ser Ser Arg 
            100                 105                 110         


Pro Leu Gln Lys Gly Ser His Pro Met Cys Lys Glu His Glu Asp Glu 
        115                 120                 125             


Lys Ile Asn Ile Tyr Cys Leu Thr Cys Glu Val Pro Thr Cys Ser Met 
    130                 135                 140                 


Cys Lys Val Phe Gly Ile His Lys Ala Cys Glu Val Ala Pro Leu Gln 
145                 150                 155                 160 


Ser Val Phe Gln Gly Gln Lys Thr Glu Leu Asn Asn Cys Ile Ser Met 
                165                 170                 175     


Leu Val Ala Gly Asn Asp Arg Val Gln Thr Ile Ile Thr Gln Leu Glu 
            180                 185                 190         


Asp Ser Arg Arg Val Thr Lys Glu Asn Ser His Gln Val Lys Glu Glu 
        195                 200                 205             


Leu Ser Gln Lys Phe Asp Thr Leu Tyr Ala Ile Leu Asp Glu Lys Lys 
    210                 215                 220                 


Ser Glu Leu Leu Gln Arg Ile Thr Gln Glu Gln Glu Lys Lys Leu Ser 
225                 230                 235                 240 


Phe Ile Glu Ala Leu Ile Gln Gln Tyr Gln Glu Gln Leu Asp Lys Ser 
                245                 250                 255     


Thr Lys Leu Val Glu Thr Ala Ile Gln Ser Leu Asp Glu Pro Gly Gly 
            260                 265                 270         


Ala Thr Phe Leu Leu Thr Ala Lys Gln Leu Ile Lys Ser Ile Val Glu 
        275                 280                 285             


Ala Ser Lys Gly Cys Gln Leu Gly Lys Thr Glu Gln Gly Phe Glu Asn 
    290                 295                 300                 


Met Asp Phe Phe Thr Leu Asp Leu Glu His Ile Ala Asp Ala Leu Arg 
305                 310                 315                 320 


Ala Ile Asp Phe Gly Thr Asp Glu Glu Glu Glu Glu Phe Ile Glu Glu 
                325                 330                 335     


Glu Asp Gln Glu Glu Glu Glu Ser Thr Glu Gly Lys Glu Glu Gly His 
            340                 345                 350         


Gln 
    


<210>  56
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Ser Ala Ser Ser Ser Arg Ala Gly Val Ala Leu Pro Phe Glu 
1               5                   10                  15      


Lys Ser Gln Leu Thr Leu Lys Val Val Ser Ala Lys Pro Lys Val His 
            20                  25                  30          


Asn Arg Gln Pro Arg Ile Asn Ser Tyr Val Glu Val Ala Val Asp Gly 
        35                  40                  45              


Leu Pro Ser Glu Thr Lys Lys Thr Gly Lys Arg Ile Gly Ser Ser Glu 
    50                  55                  60                  


Leu Leu Trp Asn Glu Ile Ile Ile Leu Asn Val Thr Ala Gln Ser His 
65                  70                  75                  80  


Leu Asp Leu Lys Val Trp Ser Cys His Thr Leu Arg Asn Glu Leu Leu 
                85                  90                  95      


Gly Thr Ala Ser Val Asn Leu Ser Asn Val Leu Lys Asn Asn Gly Gly 
            100                 105                 110         


Lys Met Glu Asn Met Gln Leu Thr Leu Asn Leu Gln Thr Glu Asn Lys 
        115                 120                 125             


Gly Ser Val Val Ser Gly Gly Glu Leu Thr Ile Phe Leu Asp Gly Pro 
    130                 135                 140                 


Thr Val Asp Leu Gly Asn Val Pro Asn Gly Ser Ala Leu Thr Asp Gly 
145                 150                 155                 160 


Ser Gln Leu Pro Ser Arg Asp Ser Ser Gly Thr Ala Val Ala Pro Glu 
                165                 170                 175     


Asn Arg His Gln Pro Pro Ser Thr Asn Cys Phe Gly Gly Arg Ser Arg 
            180                 185                 190         


Thr His Arg His Ser Gly Ala Ser Ala Arg Thr Thr Pro Ala Thr Gly 
        195                 200                 205             


Glu Gln Ser Pro Gly Ala Arg Ser Arg His Arg Gln Pro Val Lys Asn 
    210                 215                 220                 


Ser Gly His Ser Gly Leu Ala Asn Gly Thr Val Asn Asp Glu Pro Thr 
225                 230                 235                 240 


Thr Ala Thr Asp Pro Glu Glu Pro Ser Val Val Gly Val Thr Ser Pro 
                245                 250                 255     


Pro Ala Ala Pro Leu Ser Val Thr Pro Asn Pro Asn Thr Thr Ser Leu 
            260                 265                 270         


Pro Ala Pro Ala Thr Pro Ala Glu Gly Glu Glu Pro Ser Thr Ser Gly 
        275                 280                 285             


Thr Gln Gln Leu Pro Ala Ala Ala Gln Ala Pro Asp Ala Leu Pro Ala 
    290                 295                 300                 


Gly Trp Glu Gln Arg Glu Leu Pro Asn Gly Arg Val Tyr Tyr Val Asp 
305                 310                 315                 320 


His Asn Thr Lys Thr Thr Thr Trp Glu Arg Pro Leu Pro Pro Gly Trp 
                325                 330                 335     


Glu Lys Arg Thr Asp Pro Arg Gly Arg Phe Tyr Tyr Val Asp His Asn 
            340                 345                 350         


Thr Arg Thr Thr Thr Trp Gln Arg Pro Thr Ala Glu Tyr Val Arg Asn 
        355                 360                 365             


Tyr Glu Gln Trp Gln Ser Gln Arg Asn Gln Leu Gln Gly Ala Met Gln 
    370                 375                 380                 


His Phe Ser Gln Arg Phe Leu Tyr Gln Ser Ser Ser Ala Ser Thr Asp 
385                 390                 395                 400 


His Asp Pro Leu Gly Pro Leu Pro Pro Gly Trp Glu Lys Arg Gln Asp 
                405                 410                 415     


Asn Gly Arg Val Tyr Tyr Val Asn His Asn Thr Arg Thr Thr Gln Trp 
            420                 425                 430         


Glu Asp Pro Arg Thr Gln Gly Met Ile Gln Glu Pro Ala Leu Pro Pro 
        435                 440                 445             


Gly Trp Glu Met Lys Tyr Thr Ser Glu Gly Val Arg Tyr Phe Val Asp 
    450                 455                 460                 


His Asn Thr Arg Thr Thr Thr Phe Lys Asp Pro Arg Pro Gly Phe Glu 
465                 470                 475                 480 


Ser Gly Thr Lys Gln Gly Ser Pro Gly Ala Tyr Asp Arg Ser Phe Arg 
                485                 490                 495     


Trp Lys Tyr His Gln Phe Arg Phe Leu Cys His Ser Asn Ala Leu Pro 
            500                 505                 510         


Ser His Val Lys Ile Ser Val Ser Arg Gln Thr Leu Phe Glu Asp Ser 
        515                 520                 525             


Phe Gln Gln Ile Met Asn Met Lys Pro Tyr Asp Leu Arg Arg Arg Leu 
    530                 535                 540                 


Tyr Ile Ile Met Arg Gly Glu Glu Gly Leu Asp Tyr Gly Gly Ile Ala 
545                 550                 555                 560 


Arg Glu Trp Phe Phe Leu Leu Ser His Glu Val Leu Asn Pro Met Tyr 
                565                 570                 575     


Cys Leu Phe Glu Tyr Ala Gly Lys Asn Asn Tyr Cys Leu Gln Ile Asn 
            580                 585                 590         


Pro Ala Ser Ser Ile Asn Pro Asp His Leu Thr Tyr Phe Arg Phe Ile 
        595                 600                 605             


Gly Arg Phe Ile Ala Met Ala Leu Tyr His Gly Lys Phe Ile Asp Thr 
    610                 615                 620                 


Gly Phe Thr Leu Pro Phe Tyr Lys Arg Met Leu Asn Lys Arg Pro Thr 
625                 630                 635                 640 


Leu Lys Asp Leu Glu Ser Ile Asp Pro Glu Phe Tyr Asn Ser Ile Val 
                645                 650                 655     


Trp Ile Lys Glu Asn Asn Leu Glu Glu Cys Gly Leu Glu Leu Tyr Phe 
            660                 665                 670         


Ile Gln Asp Met Glu Ile Leu Gly Lys Val Thr Thr His Glu Leu Lys 
        675                 680                 685             


Glu Gly Gly Glu Ser Ile Arg Val Thr Glu Glu Asn Lys Glu Glu Tyr 
    690                 695                 700                 


Ile Met Leu Leu Thr Asp Trp Arg Phe Thr Arg Gly Val Glu Glu Gln 
705                 710                 715                 720 


Thr Lys Ala Phe Leu Asp Gly Phe Asn Glu Val Ala Pro Leu Glu Trp 
                725                 730                 735     


Leu Arg Tyr Phe Asp Glu Lys Glu Leu Glu Leu Met Leu Cys Gly Met 
            740                 745                 750         


Gln Glu Ile Asp Met Ser Asp Trp Gln Lys Ser Thr Ile Tyr Arg His 
        755                 760                 765             


Tyr Thr Lys Asn Ser Lys Gln Ile Gln Trp Phe Trp Gln Val Val Lys 
    770                 775                 780                 


Glu Met Asp Asn Glu Lys Arg Ile Arg Leu Leu Gln Phe Val Thr Gly 
785                 790                 795                 800 


Thr Cys Arg Leu Pro Val Gly Gly Phe Ala Glu Leu Ile Gly Ser Asn 
                805                 810                 815     


Gly Pro Gln Lys Phe Cys Ile Asp Lys Val Gly Lys Glu Thr Trp Leu 
            820                 825                 830         


Pro Arg Ser His Thr Cys Phe Asn Arg Leu Asp Leu Pro Pro Tyr Lys 
        835                 840                 845             


Ser Tyr Glu Gln Leu Arg Glu Lys Leu Leu Tyr Ala Ile Glu Glu Thr 
    850                 855                 860                 


Glu Gly Phe Gly Gln Glu 
865                 870 


<210>  57
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Ala Ala Ala Glu Glu Glu Asp Gly Gly Pro Glu Gly Pro Asn Arg 
1               5                   10                  15      


Glu Arg Gly Gly Ala Gly Ala Thr Phe Glu Cys Asn Ile Cys Leu Glu 
            20                  25                  30          


Thr Ala Arg Glu Ala Val Val Ser Val Cys Gly His Leu Tyr Cys Trp 
        35                  40                  45              


Pro Cys Leu His Gln Trp Leu Glu Thr Arg Pro Glu Arg Gln Glu Cys 
    50                  55                  60                  


Pro Val Cys Lys Ala Gly Ile Ser Arg Glu Lys Val Val Pro Leu Tyr 
65                  70                  75                  80  


Gly Arg Gly Ser Gln Lys Pro Gln Asp Pro Arg Leu Lys Thr Pro Pro 
                85                  90                  95      


Arg Pro Gln Gly Gln Arg Pro Ala Pro Glu Ser Arg Gly Gly Phe Gln 
            100                 105                 110         


Pro Phe Gly Asp Thr Gly Gly Phe His Phe Ser Phe Gly Val Gly Ala 
        115                 120                 125             


Phe Pro Phe Gly Phe Phe Thr Thr Val Phe Asn Ala His Glu Pro Phe 
    130                 135                 140                 


Arg Arg Gly Thr Gly Val Asp Leu Gly Gln Gly His Pro Ala Ser Ser 
145                 150                 155                 160 


Trp Gln Asp Ser Leu Phe Leu Phe Leu Ala Ile Phe Phe Phe Phe Trp 
                165                 170                 175     


Leu Leu Ser Ile 
            180 


<210>  58
<211>  875
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Glu Lys Leu His Gln Cys Tyr Trp Lys Ser Gly Glu Pro Gln Ser 
1               5                   10                  15      


Asp Asp Ile Glu Ala Ser Arg Met Lys Arg Ala Ala Ala Lys His Leu 
            20                  25                  30          


Ile Glu Arg Tyr Tyr His Gln Leu Thr Glu Gly Cys Gly Asn Glu Ala 
        35                  40                  45              


Cys Thr Asn Glu Phe Cys Ala Ser Cys Pro Thr Phe Leu Arg Met Asp 
    50                  55                  60                  


Asn Asn Ala Ala Ala Ile Lys Ala Leu Glu Leu Tyr Lys Ile Asn Ala 
65                  70                  75                  80  


Lys Leu Cys Asp Pro His Pro Ser Lys Lys Gly Ala Ser Ser Ala Tyr 
                85                  90                  95      


Leu Glu Asn Ser Lys Gly Ala Pro Asn Asn Ser Cys Ser Glu Ile Lys 
            100                 105                 110         


Met Asn Lys Lys Gly Ala Arg Ile Asp Phe Lys Asp Val Thr Tyr Leu 
        115                 120                 125             


Thr Glu Glu Lys Val Tyr Glu Ile Leu Glu Leu Cys Arg Glu Arg Glu 
    130                 135                 140                 


Asp Tyr Ser Pro Leu Ile Arg Val Ile Gly Arg Val Phe Ser Ser Ala 
145                 150                 155                 160 


Glu Ala Leu Val Gln Ser Phe Arg Lys Val Lys Gln His Thr Lys Glu 
                165                 170                 175     


Glu Leu Lys Ser Leu Gln Ala Lys Asp Glu Asp Lys Asp Glu Asp Glu 
            180                 185                 190         


Lys Glu Lys Ala Ala Cys Ser Ala Ala Ala Met Glu Glu Asp Ser Glu 
        195                 200                 205             


Ala Ser Ser Ser Arg Ile Gly Asp Ser Ser Gln Gly Asp Asn Asn Leu 
    210                 215                 220                 


Gln Lys Leu Gly Pro Asp Asp Val Ser Val Asp Ile Asp Ala Ile Arg 
225                 230                 235                 240 


Arg Val Tyr Thr Arg Leu Leu Ser Asn Glu Lys Ile Glu Thr Ala Phe 
                245                 250                 255     


Leu Asn Ala Leu Val Tyr Leu Ser Pro Asn Val Glu Cys Asp Leu Thr 
            260                 265                 270         


Tyr His Asn Val Tyr Ser Arg Asp Pro Asn Tyr Leu Asn Leu Phe Ile 
        275                 280                 285             


Ile Val Met Glu Asn Arg Asn Leu His Ser Pro Glu Tyr Leu Glu Met 
    290                 295                 300                 


Ala Leu Pro Leu Phe Cys Lys Ala Met Ser Lys Leu Pro Leu Ala Ala 
305                 310                 315                 320 


Gln Gly Lys Leu Ile Arg Leu Trp Ser Lys Tyr Asn Ala Asp Gln Ile 
                325                 330                 335     


Arg Arg Met Met Glu Thr Phe Gln Gln Leu Ile Thr Tyr Lys Val Ile 
            340                 345                 350         


Ser Asn Glu Phe Asn Ser Arg Asn Leu Val Asn Asp Asp Asp Ala Ile 
        355                 360                 365             


Val Ala Ala Ser Lys Cys Leu Lys Met Val Tyr Tyr Ala Asn Val Val 
    370                 375                 380                 


Gly Gly Glu Val Asp Thr Asn His Asn Glu Glu Asp Asp Glu Glu Pro 
385                 390                 395                 400 


Ile Pro Glu Ser Ser Glu Leu Thr Leu Gln Glu Leu Leu Gly Glu Glu 
                405                 410                 415     


Arg Arg Asn Lys Lys Gly Pro Arg Val Asp Pro Leu Glu Thr Glu Leu 
            420                 425                 430         


Gly Val Lys Thr Leu Asp Cys Arg Lys Pro Leu Ile Pro Phe Glu Glu 
        435                 440                 445             


Phe Ile Asn Glu Pro Leu Asn Glu Val Leu Glu Met Asp Lys Asp Tyr 
    450                 455                 460                 


Thr Phe Phe Lys Val Glu Thr Glu Asn Lys Phe Ser Phe Met Thr Cys 
465                 470                 475                 480 


Pro Phe Ile Leu Asn Ala Val Thr Lys Asn Leu Gly Leu Tyr Tyr Asp 
                485                 490                 495     


Asn Arg Ile Arg Met Tyr Ser Glu Arg Arg Ile Thr Val Leu Tyr Ser 
            500                 505                 510         


Leu Val Gln Gly Gln Gln Leu Asn Pro Tyr Leu Arg Leu Lys Val Arg 
        515                 520                 525             


Arg Asp His Ile Ile Asp Asp Ala Leu Val Arg Leu Glu Met Ile Ala 
    530                 535                 540                 


Met Glu Asn Pro Ala Asp Leu Lys Lys Gln Leu Tyr Val Glu Phe Glu 
545                 550                 555                 560 


Gly Glu Gln Gly Val Asp Glu Gly Gly Val Ser Lys Glu Phe Phe Gln 
                565                 570                 575     


Leu Val Val Glu Glu Ile Phe Asn Pro Asp Ile Gly Met Phe Thr Tyr 
            580                 585                 590         


Asp Glu Ser Thr Lys Leu Phe Trp Phe Asn Pro Ser Ser Phe Glu Thr 
        595                 600                 605             


Glu Gly Gln Phe Thr Leu Ile Gly Ile Val Leu Gly Leu Ala Ile Tyr 
    610                 615                 620                 


Asn Asn Cys Ile Leu Asp Val His Phe Pro Met Val Val Tyr Arg Lys 
625                 630                 635                 640 


Leu Met Gly Lys Lys Gly Thr Phe Arg Asp Leu Gly Asp Ser His Pro 
                645                 650                 655     


Val Leu Tyr Gln Ser Leu Lys Asp Leu Leu Glu Tyr Glu Gly Asn Val 
            660                 665                 670         


Glu Asp Asp Met Met Ile Thr Phe Gln Ile Ser Gln Thr Asp Leu Phe 
        675                 680                 685             


Gly Asn Pro Met Met Tyr Asp Leu Lys Glu Asn Gly Asp Lys Ile Pro 
    690                 695                 700                 


Ile Thr Asn Glu Asn Arg Lys Glu Phe Val Asn Leu Tyr Ser Asp Tyr 
705                 710                 715                 720 


Ile Leu Asn Lys Ser Val Glu Lys Gln Phe Lys Ala Phe Arg Arg Gly 
                725                 730                 735     


Phe His Met Val Thr Asn Glu Ser Pro Leu Lys Tyr Leu Phe Arg Pro 
            740                 745                 750         


Glu Glu Ile Glu Leu Leu Ile Cys Gly Ser Arg Asn Leu Asp Phe Gln 
        755                 760                 765             


Ala Leu Glu Glu Thr Thr Glu Tyr Asp Gly Gly Tyr Thr Arg Asp Ser 
    770                 775                 780                 


Val Leu Ile Arg Glu Phe Trp Glu Ile Val His Ser Phe Thr Asp Glu 
785                 790                 795                 800 


Gln Lys Arg Leu Phe Leu Gln Phe Thr Thr Gly Thr Asp Arg Ala Pro 
                805                 810                 815     


Val Gly Gly Leu Gly Lys Leu Lys Met Ile Ile Ala Lys Asn Gly Pro 
            820                 825                 830         


Asp Thr Glu Arg Leu Pro Thr Ser His Thr Cys Phe Asn Val Leu Leu 
        835                 840                 845             


Leu Pro Glu Tyr Ser Ser Lys Glu Lys Leu Lys Glu Arg Leu Leu Lys 
    850                 855                 860                 


Ala Ile Thr Tyr Ala Lys Gly Phe Gly Met Leu 
865                 870                 875 


<210>  59
<211>  1068
<212>  PRT
<213>  Homo sapiens

<400>  59

Met Phe Thr Leu Ser Gln Thr Ser Arg Ala Trp Phe Ile Asp Arg Ala 
1               5                   10                  15      


Arg Gln Ala Arg Glu Glu Arg Leu Val Gln Lys Glu Arg Glu Arg Ala 
            20                  25                  30          


Ala Val Val Ile Gln Ala His Val Arg Ser Phe Leu Cys Arg Ser Arg 
        35                  40                  45              


Leu Gln Arg Asp Ile Arg Arg Glu Ile Asp Asp Phe Phe Lys Ala Asp 
    50                  55                  60                  


Asp Pro Glu Ser Thr Lys Arg Ser Ala Leu Cys Ile Phe Lys Ile Ala 
65                  70                  75                  80  


Arg Lys Leu Leu Phe Leu Phe Arg Ile Lys Glu Asp Asn Glu Arg Phe 
                85                  90                  95      


Glu Lys Leu Cys Arg Ser Ile Leu Ser Ser Met Asp Ala Glu Asn Glu 
            100                 105                 110         


Pro Lys Val Trp Tyr Val Ser Leu Ala Cys Ser Lys Asp Leu Thr Leu 
        115                 120                 125             


Leu Trp Ile Gln Gln Ile Lys Asn Ile Leu Trp Tyr Cys Cys Asp Phe 
    130                 135                 140                 


Leu Lys Gln Leu Lys Pro Glu Ile Leu Gln Asp Ser Arg Leu Ile Thr 
145                 150                 155                 160 


Leu Tyr Leu Thr Met Leu Val Thr Phe Thr Asp Thr Ser Thr Trp Lys 
                165                 170                 175     


Ile Leu Arg Gly Lys Gly Glu Ser Leu Arg Pro Ala Met Asn His Ile 
            180                 185                 190         


Cys Ala Asn Ile Met Gly His Leu Asn Gln His Gly Phe Tyr Ser Val 
        195                 200                 205             


Leu Gln Ile Leu Leu Thr Arg Gly Leu Ala Arg Pro Arg Pro Cys Leu 
    210                 215                 220                 


Ser Lys Gly Thr Leu Thr Ala Ala Phe Ser Leu Ala Leu Arg Pro Val 
225                 230                 235                 240 


Ile Ala Ala Gln Phe Ser Asp Asn Leu Ile Arg Pro Phe Leu Ile His 
                245                 250                 255     


Ile Met Ser Val Pro Ala Leu Val Thr His Leu Ser Thr Val Thr Pro 
            260                 265                 270         


Glu Arg Leu Thr Val Leu Glu Ser His Asp Met Leu Arg Lys Phe Ile 
        275                 280                 285             


Ile Phe Leu Arg Asp Gln Asp Arg Cys Arg Asp Val Cys Glu Ser Leu 
    290                 295                 300                 


Glu Gly Cys His Thr Leu Cys Leu Met Gly Asn Leu Leu His Leu Gly 
305                 310                 315                 320 


Ser Leu Ser Pro Arg Val Leu Glu Glu Glu Thr Asp Gly Phe Val Ser 
                325                 330                 335     


Leu Leu Thr Gln Thr Leu Cys Tyr Cys Arg Lys Tyr Val Ser Gln Lys 
            340                 345                 350         


Lys Ser Asn Leu Thr His Trp His Pro Val Leu Gly Trp Phe Ser Gln 
        355                 360                 365             


Ser Val Asp Tyr Gly Leu Asn Glu Ser Met His Leu Ile Thr Lys Gln 
    370                 375                 380                 


Leu Gln Phe Leu Trp Gly Val Pro Leu Ile Arg Ile Phe Phe Cys Asp 
385                 390                 395                 400 


Ile Leu Ser Lys Lys Leu Leu Glu Ser Gln Glu Pro Ala His Ala Gln 
                405                 410                 415     


Pro Ala Ser Pro Gln Asn Val Leu Pro Val Lys Ser Leu Leu Lys Arg 
            420                 425                 430         


Ala Phe Gln Lys Ser Ala Ser Val Arg Asn Ile Leu Arg Pro Val Gly 
        435                 440                 445             


Gly Lys Arg Val Asp Ser Ala Glu Val Gln Lys Val Cys Asn Ile Cys 
    450                 455                 460                 


Val Leu Tyr Gln Thr Ser Leu Thr Thr Leu Thr Gln Ile Arg Leu Gln 
465                 470                 475                 480 


Ile Leu Thr Gly Leu Thr Tyr Leu Asp Asp Leu Leu Pro Lys Leu Trp 
                485                 490                 495     


Ala Phe Ile Cys Glu Leu Gly Pro His Gly Gly Leu Lys Leu Phe Leu 
            500                 505                 510         


Glu Cys Leu Asn Asn Asp Thr Glu Glu Ser Lys Gln Leu Leu Ala Met 
        515                 520                 525             


Leu Met Leu Phe Cys Asp Cys Ser Arg His Leu Ile Thr Ile Leu Asp 
    530                 535                 540                 


Asp Ile Glu Val Tyr Glu Glu Gln Ile Ser Phe Lys Leu Glu Glu Leu 
545                 550                 555                 560 


Val Thr Ile Ser Ser Phe Leu Asn Ser Phe Val Phe Lys Met Ile Trp 
                565                 570                 575     


Asp Gly Ile Val Glu Asn Ala Lys Gly Glu Thr Leu Glu Leu Phe Gln 
            580                 585                 590         


Ser Val His Gly Trp Leu Met Val Leu Tyr Glu Arg Asp Cys Arg Arg 
        595                 600                 605             


Arg Phe Thr Pro Glu Asp His Trp Leu Arg Lys Asp Leu Lys Pro Ser 
    610                 615                 620                 


Val Leu Phe Gln Glu Leu Asp Arg Asp Arg Lys Arg Ala Gln Leu Ile 
625                 630                 635                 640 


Leu Gln Tyr Ile Pro His Val Ile Pro His Lys Asn Arg Val Leu Leu 
                645                 650                 655     


Phe Arg Thr Met Val Thr Lys Glu Lys Glu Lys Leu Gly Leu Val Glu 
            660                 665                 670         


Thr Ser Ser Ala Ser Pro His Val Thr His Ile Thr Ile Arg Arg Ser 
        675                 680                 685             


Arg Met Leu Glu Asp Gly Tyr Glu Gln Leu Arg Gln Leu Ser Gln His 
    690                 695                 700                 


Ala Met Lys Gly Val Ile Arg Val Lys Phe Val Asn Asp Leu Gly Val 
705                 710                 715                 720 


Asp Glu Ala Gly Ile Asp Gln Asp Gly Val Phe Lys Glu Phe Leu Glu 
                725                 730                 735     


Glu Ile Ile Lys Arg Val Phe Asp Pro Ala Leu Asn Leu Phe Lys Thr 
            740                 745                 750         


Thr Ser Gly Asp Glu Arg Leu Tyr Pro Ser Pro Thr Ser Tyr Ile His 
        755                 760                 765             


Glu Asn Tyr Leu Gln Leu Phe Glu Phe Val Gly Lys Met Leu Gly Lys 
    770                 775                 780                 


Ala Val Tyr Glu Gly Ile Val Val Asp Val Pro Phe Ala Ser Phe Phe 
785                 790                 795                 800 


Leu Ser Gln Leu Leu Gly His His His Ser Val Phe Tyr Ser Ser Val 
                805                 810                 815     


Asp Glu Leu Pro Ser Leu Asp Ser Glu Phe Tyr Lys Asn Leu Thr Ser 
            820                 825                 830         


Ile Lys Arg Tyr Asp Gly Asp Ile Thr Asp Leu Gly Leu Thr Leu Ser 
        835                 840                 845             


Tyr Asp Glu Asp Val Met Gly Gln Leu Val Cys His Glu Leu Ile Pro 
    850                 855                 860                 


Gly Gly Lys Thr Ile Pro Val Thr Asn Glu Asn Lys Ile Ser Tyr Ile 
865                 870                 875                 880 


His Leu Met Ala His Phe Arg Met His Thr Gln Ile Lys Asn Gln Thr 
                885                 890                 895     


Ala Ala Leu Ile Ser Gly Phe Arg Ser Ile Ile Lys Pro Glu Trp Ile 
            900                 905                 910         


Arg Met Phe Ser Thr Pro Glu Leu Gln Arg Leu Ile Ser Gly Asp Asn 
        915                 920                 925             


Ala Glu Ile Asp Leu Glu Asp Leu Lys Lys His Thr Val Tyr Tyr Gly 
    930                 935                 940                 


Gly Phe His Gly Ser His Arg Val Ile Ile Trp Leu Trp Asp Ile Leu 
945                 950                 955                 960 


Ala Ser Asp Phe Thr Pro Asp Glu Arg Ala Met Phe Leu Lys Phe Val 
                965                 970                 975     


Thr Ser Cys Ser Arg Pro Pro Leu Leu Gly Phe Ala Tyr Leu Lys Pro 
            980                 985                 990         


Pro Phe Ser Ile Arg Cys Val Glu  Val Ser Asp Asp Gln  Asp Thr Gly 
        995                 1000                 1005             


Asp Thr  Leu Gly Ser Val Leu  Arg Gly Phe Phe Thr  Ile Arg Lys 
    1010                 1015                 1020             


Arg Glu  Pro Gly Gly Arg Leu  Pro Thr Ser Ser Thr  Cys Phe Asn 
    1025                 1030                 1035             


Leu Leu  Lys Leu Pro Asn Tyr  Ser Lys Lys Ser Val  Leu Arg Glu 
    1040                 1045                 1050             


Lys Leu  Arg Tyr Ala Ile Ser  Met Asn Thr Gly Phe  Glu Leu Ser 
    1055                 1060                 1065             


<210>  60
<211>  216
<212>  PRT
<213>  Escherichia coli

<400>  60

Met Pro Phe Ser Phe Asn Leu Ser Ser Gly Asn Tyr Leu Ser Thr Gln 
1               5                   10                  15      


Asp Val Glu Val Leu Gln Arg Ala Thr Arg Asp His Gln Met Glu Arg 
            20                  25                  30          


Leu Thr Ile Gly Glu Arg Ser Phe Ser Val Arg Tyr Gln Ser Ala Met 
        35                  40                  45              


Asp Ala Phe Ile Val Asp Pro Val Gln Gly Glu Leu Tyr Ser Gly Leu 
    50                  55                  60                  


Ser His Thr Glu Leu Ala Asp Ile Ile Arg Leu Ala Asp Ser Val Glu 
65                  70                  75                  80  


Asn Gln Leu Asn Gly Gly Asn Ser Phe Leu Asp Val Phe Ser Thr Tyr 
                85                  90                  95      


Met Gly Gln Val Ile Ser Glu Phe Met His Ser Asn Asp Asn Arg Ile 
            100                 105                 110         


Glu Leu Leu Gln Arg Arg Leu His Ser Cys Ser Phe Leu Val Asn Ile 
        115                 120                 125             


Glu Glu Met Ser Tyr Ile Asp Glu Ala Leu Gln Cys Pro Ile Thr Leu 
    130                 135                 140                 


Ala Ile Pro Gln Arg Gly Val Phe Leu Arg Asn Ala Glu Gly Ser Arg 
145                 150                 155                 160 


Val Cys Ser Leu Tyr Asp Glu Met Ala Leu Ser Arg Ile Ile Asn Asp 
                165                 170                 175     


Gly Met His His Pro Leu Ser Arg Glu Pro Ile Thr Leu Ser Met Leu 
            180                 185                 190         


Val Ala Arg Glu Gln Cys Glu Phe Asp Cys Ser Ile Gly His Phe Thr 
        195                 200                 205             


Val Arg Ser Asp Cys Tyr Ser Val 
    210                 215     


<210>  61
<211>  140
<212>  PRT
<213>  Escherichia coli

<400>  61

Met Glu Arg Arg Ala Val Ala Leu Glu Arg Gln Leu Asn Gly Gly Val 
1               5                   10                  15      


Asp Phe Leu Arg Ser Val Asn Asn Tyr Phe Gln Ser Val Met Ala Glu 
            20                  25                  30          


His Arg Glu Asn Lys Thr Ser Asn Lys Ile Leu Met Glu Lys Ile Asn 
        35                  40                  45              


Ser Cys Val Phe Gly Thr Asp Ser Asn His Phe Ser Cys Pro Glu Ser 
    50                  55                  60                  


Phe Leu Thr Cys Pro Ile Thr Leu Asp Thr Pro Ala Asn Gly Val Phe 
65                  70                  75                  80  


Met Arg Asn Ser Gln Gly Ala Glu Ile Cys Ser Leu Tyr Asp Lys Asp 
                85                  90                  95      


Thr Leu Val Gln Leu Val Glu Thr Gly Gly Ala His Pro Leu Ser Arg 
            100                 105                 110         


Glu Pro Ile Thr Glu Ser Met Ile Met Arg Lys Asp Glu Cys His Phe 
        115                 120                 125             


Asp Ser Lys Lys Glu Ser Phe Val Ala Ser Asp Ala 
    130                 135                 140 


<210>  62
<211>  123
<212>  PRT
<213>  Escherichia coli

<400>  62

Met Leu Gln Leu Ser Ser Asn Ile Gly Trp Lys Lys Gly Ala Glu Asn 
1               5                   10                  15      


Ala Leu Lys Asn Lys Ile His Ser His Ser Phe Val Val Asn Pro Asp 
            20                  25                  30          


Glu Phe Ser Cys Asp Thr Gln Phe Leu Lys Cys Pro Ile Thr Leu Cys 
        35                  40                  45              


Val Pro Glu Lys Gly Val Phe Val Lys Asn Ala Leu Asn Ser Asn Ile 
    50                  55                  60                  


Cys Thr Leu Tyr Asp Lys Ser Ala Phe Met Asn Leu Thr Arg Glu His 
65                  70                  75                  80  


Leu Pro His Pro Leu Ser Arg Glu Lys Ile Val Lys Glu Met Ile Ile 
                85                  90                  95      


Glu Arg Asn Met Cys Tyr Phe Asp Thr Ile Ser Gln His Phe Ile Ile 
            100                 105                 110         


Met Asp Ala Asp Gln Gln Lys Gln His Cys Lys 
        115                 120             


<210>  63
<211>  660
<212>  DNA
<213>  Artificial sequence

<220>
<223>  An exemplary DNA sequence that encodes full length CAT

<400>  63
atggagaaaa aaatcactgg atataccacc gttgatatat cccaatggca tcgtaaagaa       60

cattttgagg catttcagtc agttgctcaa tgtacctata accagaccgt tcagctggat      120

attacggcct ttttaaagac cgtaaagaaa aataagcaca agttttatcc ggcctttatt      180

cacattcttg cccgcctgat gaatgctcat ccggaattcc gtatggcaat gaaagacggt      240

gagctggtga tatgggatag tgttcaccct tgttacaccg ttttccatga gcaaactgaa      300

acgttttcat cgctctggag tgaataccac gacgatttcc ggcagtttct acacatatat      360

tcgcaagatg tggcgtgtta cggtgaaaac ctggcctatt tccctaaagg gtttattgag      420

aatatgtttt tcgtctcagc caatccctgg gtgagtttca ccagttttga tttaaacgtg      480

gccaatatgg acaacttctt cgcccccgtt ttcaccatgg gcaaatatta tacgcaaggc      540

gacaaggtgc tgatgccgct ggcgattcag gttcatcatg ccgtctgtga tggcttccat      600

gtcggcagaa tgcttaatga attacaacag tactgcgatg agtggcaggg cggggcgtaa      660


<210>  64
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  amino acid sequence of CAT

<400>  64

Met Glu Lys Lys Ile Thr Gly Tyr Thr Thr Val Asp Ile Ser Gln Trp 
1               5                   10                  15      


His Arg Lys Glu His Phe Glu Ala Phe Gln Ser Val Ala Gln Cys Thr 
            20                  25                  30          


Tyr Asn Gln Thr Val Gln Leu Asp Ile Thr Ala Phe Leu Lys Thr Val 
        35                  40                  45              


Lys Lys Asn Lys His Lys Phe Tyr Pro Ala Phe Ile His Ile Leu Ala 
    50                  55                  60                  


Arg Leu Met Asn Ala His Pro Glu Phe Arg Met Ala Met Lys Asp Gly 
65                  70                  75                  80  


Glu Leu Val Ile Trp Asp Ser Val His Pro Cys Tyr Thr Val Phe His 
                85                  90                  95      


Glu Gln Thr Glu Thr Phe Ser Ser Leu Trp Ser Glu Tyr His Asp Asp 
            100                 105                 110         


Phe Arg Gln Phe Leu His Ile Tyr Ser Gln Asp Val Ala Cys Tyr Gly 
        115                 120                 125             


Glu Asn Leu Ala Tyr Phe Pro Lys Gly Phe Ile Glu Asn Met Phe Phe 
    130                 135                 140                 


Val Ser Ala Asn Pro Trp Val Ser Phe Thr Ser Phe Asp Leu Asn Val 
145                 150                 155                 160 


Ala Asn Met Asp Asn Phe Phe Ala Pro Val Phe Thr Met Gly Lys Tyr 
                165                 170                 175     


Tyr Thr Gln Gly Asp Lys Val Leu Met Pro Leu Ala Ile Gln Val His 
            180                 185                 190         


His Ala Val Cys Asp Gly Phe His Val Gly Arg Met Leu Asn Glu Leu 
        195                 200                 205             


Gln Gln Tyr Cys Asp Glu Trp Gln Gly Gly Ala 
    210                 215                 


<210>  65
<211>  93
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CAT N-terminal fragment nucleic acid sequence

<400>  65
atggagaaaa aaatcactgg atataccacc gttgatatat cccaatggca tcgtaaagaa       60

cattttgagg catttcagtc agttgctcaa taa                                    93


<210>  66
<211>  573
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CAT C-terminal fragment  nucleic acid sequence

<400>  66
atgtgtacct ataaccagac cgttcagctg gatattacgg cctttttaaa gaccgtaaag       60

aaaaataagc acaagtttta tccggccttt attcacattc ttgcccgcct gatgaatgct      120

catccggaat tccgtatggc aatgaaagac ggtgagctgg tgatatggga tagtgttcac      180

ccttgttaca ccgttttcca tgagcaaact gaaacgtttt catcgctctg gagtgaatac      240

cacgacgatt tccggcagtt tctacacata tattcgcaag atgtggcgtg ttacggtgaa      300

aacctggcct atttccctaa agggtttatt gagaatatgt ttttcgtctc agccaatccc      360

tgggtgagtt tcaccagttt tgatttaaac gtggccaata tggacaactt cttcgccccc      420

gttttcacca tgggcaaata ttatacgcaa ggcgacaagg tgctgatgcc gctggcgatt      480

caggttcatc atgccgtctg tgatggcttc catgtcggca gaatgcttaa tgaattacaa      540

cagtactgcg atgagtggca gggcggggcg taa                                   573


<210>  67
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CAT N-terminal fragment amino acid sequence

<400>  67

Met Glu Lys Lys Ile Thr Gly Tyr Thr Thr Val Asp Ile Ser Gln Trp 
1               5                   10                  15      


His Arg Lys Glu His Phe Glu Ala Phe Gln Ser Val Ala Gln 
            20                  25                  30  


<210>  68
<211>  190
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CAT C-terminal fragment  amino acid sequence

<400>  68

Met Cys Thr Tyr Asn Gln Thr Val Gln Leu Asp Ile Thr Ala Phe Leu 
1               5                   10                  15      


Lys Thr Val Lys Lys Asn Lys His Lys Phe Tyr Pro Ala Phe Ile His 
            20                  25                  30          


Ile Leu Ala Arg Leu Met Asn Ala His Pro Glu Phe Arg Met Ala Met 
        35                  40                  45              


Lys Asp Gly Glu Leu Val Ile Trp Asp Ser Val His Pro Cys Tyr Thr 
    50                  55                  60                  


Val Phe His Glu Gln Thr Glu Thr Phe Ser Ser Leu Trp Ser Glu Tyr 
65                  70                  75                  80  


His Asp Asp Phe Arg Gln Phe Leu His Ile Tyr Ser Gln Asp Val Ala 
                85                  90                  95      


Cys Tyr Gly Glu Asn Leu Ala Tyr Phe Pro Lys Gly Phe Ile Glu Asn 
            100                 105                 110         


Met Phe Phe Val Ser Ala Asn Pro Trp Val Ser Phe Thr Ser Phe Asp 
        115                 120                 125             


Leu Asn Val Ala Asn Met Asp Asn Phe Phe Ala Pro Val Phe Thr Met 
    130                 135                 140                 


Gly Lys Tyr Tyr Thr Gln Gly Asp Lys Val Leu Met Pro Leu Ala Ile 
145                 150                 155                 160 


Gln Val His His Ala Val Cys Asp Gly Phe His Val Gly Arg Met Leu 
                165                 170                 175     


Asn Glu Leu Gln Gln Tyr Cys Asp Glu Trp Gln Gly Gly Ala 
            180                 185                 190 


