                         SEQUENCE LISTING

<110>  Chen, Danica
       Luo, Hanzhi
 
<120>  COMPOSITIONS AND METHODS FOR INHIBITING STEM CELL AGING

<130>  BERK-341WO

<150>  62/380,101
<151>  2016-08-26

<160>  54    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  1

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  2
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  2

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  3
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  3

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  4
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  4

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  5
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  5

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  6

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  7

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  8

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  9
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  9

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  10
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  10

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  11
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  11

Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr Pro Pro Glu Lys Gly 
1               5                   10                  15      


<210>  12
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  12

Lys Leu Ala Gln Tyr Leu Glu Asp Leu Glu Asp Val Asp Leu Lys Lys 
1               5                   10                  15      


Phe Lys Met His Leu Glu 
            20          


<210>  13
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  13

Phe Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Ile 
1               5                   10                  15      


Met Leu Asp Trp Ala Leu Gly Lys Leu Phe 
            20                  25      


<210>  14
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  14

Lys Asp Lys Phe Asp Tyr Leu Phe Phe Ile His Cys Arg Glu 
1               5                   10                  


<210>  15
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  15

Arg Lys Gly Pro Gly Gly Cys Ser Asp Leu Leu Asn Arg Asp 
1               5                   10                  


<210>  16
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  16

Tyr Leu Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Val Arg Leu 
1               5                   10                  15      


Glu Leu Leu Lys Trp 
            20      


<210>  17
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  17

Tyr Leu Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Val Arg Leu 
1               5                   10                  15      


Glu 
    


<210>  18
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  18

Arg Leu Tyr Ile Gly Glu Asn Ala Leu Gly Asp Ser Gly Val Gln Val 
1               5                   10                  15      


Leu Cys Glu Lys Met Lys Asp Pro Gln Cys Asn Leu Gln 
            20                  25                  


<210>  19
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  19

Leu Tyr Ile Gly Glu Asn Ala Leu Gly Asp Ser Gly Val Gln Val Leu 
1               5                   10                  15      


Cys Glu Lys Met Lys Asp Pro Gln Cys Asn Leu Gln 
            20                  25              


<210>  20
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  20

Arg Leu Tyr Ile Gly Glu Asn Ala Leu Gly Asp Ser Gly Val Gln Val 
1               5                   10                  15      


Leu Cys Glu Lys Met Lys Asp Pro Gln Cys Asn Leu 
            20                  25              


<210>  21
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  21

Arg Lys Leu Asn Leu Gly Asn Asn Asp Leu Gly Asp Leu Cys Val Val 
1               5                   10                  15      


Thr Leu Cys Glu Val Leu Lys Gln 
            20                  


<210>  22
<211>  829
<212>  PRT
<213>  Mus musculus

<400>  22

Met Thr Ser Val Arg Cys Lys Leu Ala Gln Tyr Leu Glu Asp Leu Glu 
1               5                   10                  15      


Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr Pro Pro 
            20                  25                  30          


Glu Lys Gly Cys Ile Pro Val Pro Arg Gly Gln Met Glu Lys Ala Asp 
        35                  40                  45              


His Leu Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu Glu Lys 
    50                  55                  60                  


Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg Arg Asp 
65                  70                  75                  80  


Leu Trp Glu Lys Ala Lys Lys Asp Gln Pro Glu Trp Asn Asp Thr Cys 
                85                  90                  95      


Thr Ser His Ser Ser Met Val Cys Gln Glu Asp Ser Leu Glu Glu Glu 
            100                 105                 110         


Trp Met Gly Leu Leu Gly Tyr Leu Ser Arg Ile Ser Ile Cys Lys Lys 
        115                 120                 125             


Lys Lys Asp Tyr Cys Lys Met Tyr Arg Arg His Val Arg Ser Arg Phe 
    130                 135                 140                 


Tyr Ser Ile Lys Asp Arg Asn Ala Arg Leu Gly Glu Ser Val Asp Leu 
145                 150                 155                 160 


Asn Ser Arg Tyr Thr Gln Leu Gln Leu Val Lys Glu His Pro Ser Lys 
                165                 170                 175     


Gln Glu Arg Glu His Glu Leu Leu Thr Ile Gly Arg Thr Lys Met Arg 
            180                 185                 190         


Asp Ser Pro Met Ser Ser Leu Lys Leu Glu Leu Leu Phe Glu Pro Glu 
        195                 200                 205             


Asp Gly His Ser Glu Pro Val His Thr Val Val Phe Gln Gly Ala Ala 
    210                 215                 220                 


Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Ile Met Leu Asp Trp Ala 
225                 230                 235                 240 


Leu Gly Lys Leu Phe Lys Asp Lys Phe Asp Tyr Leu Phe Phe Ile His 
                245                 250                 255     


Cys Arg Glu Val Ser Leu Arg Thr Pro Arg Ser Leu Ala Asp Leu Ile 
            260                 265                 270         


Val Ser Cys Trp Pro Asp Pro Asn Pro Pro Val Cys Lys Ile Leu Arg 
        275                 280                 285             


Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe Asp Glu Leu Gln 
    290                 295                 300                 


Gly Ala Phe Asp Glu His Ile Gly Glu Val Cys Thr Asp Trp Gln Lys 
305                 310                 315                 320 


Ala Val Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile Arg Lys Lys Leu 
                325                 330                 335     


Leu Pro Lys Ala Ser Leu Leu Ile Thr Thr Arg Pro Val Ala Leu Glu 
            340                 345                 350         


Lys Leu Gln His Leu Leu Asp His Pro Arg His Val Glu Ile Leu Gly 
        355                 360                 365             


Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys Tyr Phe Ser Asn 
    370                 375                 380                 


Glu Leu Gln Ala Arg Glu Ala Phe Arg Leu Ile Gln Glu Asn Glu Val 
385                 390                 395                 400 


Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp Ile Val Cys Thr 
                405                 410                 415     


Gly Leu Lys Gln Gln Met Glu Thr Gly Lys Ser Leu Ala Gln Thr Ser 
            420                 425                 430         


Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser Ser Leu Leu Gln 
        435                 440                 445             


Ser Arg Gly Gly Ile Glu Glu His Leu Phe Ser Asp Tyr Leu Gln Gly 
    450                 455                 460                 


Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln Lys Ile Leu Phe 
465                 470                 475                 480 


Glu Glu Cys Asp Leu Arg Lys His Gly Leu Gln Lys Thr Asp Val Ser 
                485                 490                 495     


Ala Phe Leu Arg Met Asn Val Phe Gln Lys Glu Val Asp Cys Glu Arg 
            500                 505                 510         


Phe Tyr Ser Phe Ser His Met Thr Phe Gln Glu Phe Phe Ala Ala Met 
        515                 520                 525             


Tyr Tyr Leu Leu Glu Glu Glu Ala Glu Gly Glu Thr Val Arg Lys Gly 
    530                 535                 540                 


Pro Gly Gly Cys Ser Asp Leu Leu Asn Arg Asp Val Lys Val Leu Leu 
545                 550                 555                 560 


Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val Val Arg 
                565                 570                 575     


Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu Glu Lys 
            580                 585                 590         


Lys Leu Ser Cys Lys Ile Ser Gln Gln Val Arg Leu Glu Leu Leu Lys 
        595                 600                 605             


Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Trp Gln Pro Ser 
    610                 615                 620                 


Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu Asp Phe 
625                 630                 635                 640 


Val Gln Ser Ala Met Asp His Phe Pro Lys Ile Glu Ile Asn Leu Ser 
                645                 650                 655     


Thr Arg Met Asp His Val Val Ser Ser Phe Cys Ile Lys Asn Cys His 
            660                 665                 670         


Arg Val Lys Thr Leu Ser Leu Gly Phe Phe His Asn Ser Pro Lys Glu 
        675                 680                 685             


Glu Glu Glu Glu Arg Arg Gly Gly Arg Pro Leu Asp Gln Val Gln Cys 
    690                 695                 700                 


Val Phe Pro Asp Thr His Val Ala Cys Ser Ser Arg Leu Val Asn Cys 
705                 710                 715                 720 


Cys Leu Thr Ser Ser Phe Cys Arg Gly Leu Phe Ser Ser Leu Ser Thr 
                725                 730                 735     


Asn Arg Ser Leu Thr Glu Leu Asp Leu Ser Asp Asn Thr Leu Gly Asp 
            740                 745                 750         


Pro Gly Met Arg Val Leu Cys Glu Ala Leu Gln His Pro Gly Cys Asn 
        755                 760                 765             


Ile Gln Arg Leu Trp Leu Gly Arg Cys Gly Leu Ser His Gln Cys Cys 
    770                 775                 780                 


Phe Asp Ile Ser Ser Val Leu Ser Ser Ser Gln Lys Leu Val Glu Leu 
785                 790                 795                 800 


Asp Leu Ser Asp Asn Ala Leu Gly Asp Phe Gly Ile Arg Leu Leu Cys 
                805                 810                 815     


Val Gly Leu Lys His Leu Leu Cys Asn Leu Gln Lys Leu 
            820                 825                 


<210>  23
<211>  1016
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly Leu 
705                 710                 715                 720 


Val Asn Ser His Leu Thr Ser Ser Phe Cys Arg Gly Leu Phe Ser Val 
                725                 730                 735     


Leu Ser Thr Ser Gln Ser Leu Thr Glu Leu Asp Leu Ser Asp Asn Ser 
            740                 745                 750         


Leu Gly Asp Pro Gly Met Arg Val Leu Cys Glu Thr Leu Gln His Pro 
        755                 760                 765             


Gly Cys Asn Ile Arg Arg Leu Cys Asn Gln Lys Leu Val Glu Leu Asp 
    770                 775                 780                 


Leu Ser Asp Asn Ala Leu Gly Asp Phe Gly Ile Arg Leu Leu Cys Val 
785                 790                 795                 800 


Gly Leu Lys His Leu Leu Cys Asn Leu Lys Lys Leu Trp Leu Val Ser 
                805                 810                 815     


Cys Cys Leu Thr Ser Ala Cys Cys Gln Asp Leu Ala Ser Val Leu Ser 
            820                 825                 830         


Thr Ser His Ser Leu Thr Arg Leu Tyr Val Gly Glu Asn Ala Leu Gly 
        835                 840                 845             


Asp Ser Gly Val Ala Ile Leu Cys Glu Lys Ala Lys Asn Pro Gln Cys 
    850                 855                 860                 


Asn Leu Gln Lys Leu Gly Leu Val Asn Ser Gly Leu Thr Ser Val Cys 
865                 870                 875                 880 


Cys Ser Ala Leu Ser Ser Val Leu Ser Thr Asn Gln Asn Leu Thr His 
                885                 890                 895     


Leu Tyr Leu Arg Gly Asn Thr Leu Gly Asp Lys Gly Ile Lys Leu Leu 
            900                 905                 910         


Cys Glu Gly Leu Leu His Pro Asp Cys Lys Leu Gln Val Leu Glu Leu 
        915                 920                 925             


Asp Asn Cys Asn Leu Thr Ser His Cys Cys Trp Asp Leu Ser Thr Leu 
    930                 935                 940                 


Leu Thr Ser Ser Gln Ser Leu Arg Lys Leu Ser Leu Gly Asn Asn Asp 
945                 950                 955                 960 


Leu Gly Asp Leu Gly Val Met Met Phe Cys Glu Val Leu Lys Gln Gln 
                965                 970                 975     


Ser Cys Leu Leu Gln Asn Leu Gly Leu Ser Glu Met Tyr Phe Asn Tyr 
            980                 985                 990         


Glu Thr Lys Ser Ala Leu Glu Thr  Leu Gln Glu Glu Lys  Pro Glu Leu 
        995                 1000                 1005             


Thr Val  Val Phe Glu Pro Ser  Trp 
    1010                 1015     


<210>  24
<211>  1035
<212>  PRT
<213>  Macaca mulatta

<400>  24

Met Lys Met Met Ser Val Arg Cys Lys Leu Ala Gln Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Glu Lys Gly Cys Val Pro Ile Pro Arg Gly Gln Met Glu Lys 
        35                  40                  45              


Ala Asp His Leu Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Gly Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Trp Glu Lys Ala Lys Lys Asp Gln Pro Glu Trp Asn Asp 
                85                  90                  95      


Ala Cys Thr Ser Asn Leu Ser Met Val Cys Gln Glu Asp Ser Leu Glu 
            100                 105                 110         


Glu Glu Trp Ile Gly Leu Leu Gly Tyr Leu Ser Arg Ile Ser Ile Cys 
        115                 120                 125             


Lys Lys Lys Lys Asp Tyr Cys Lys Ile Tyr Arg Arg His Val Arg Ser 
    130                 135                 140                 


Arg Phe Tyr Ser Ile Lys Asp Arg Asn Ala Arg Leu Gly Glu Ser Val 
145                 150                 155                 160 


Asp Leu Asn Arg Arg Tyr Thr Gln Leu Gln Leu Val Lys Glu His Pro 
                165                 170                 175     


Ser Lys Gln Glu Arg Glu His Glu Leu Leu Thr Ile Gly Arg Thr Lys 
            180                 185                 190         


Met Trp Asp Arg Pro Met Ser Ser Leu Lys Leu Glu Leu Leu Phe Glu 
        195                 200                 205             


Pro Glu Asp Glu His Leu Glu Pro Val His Thr Val Val Phe Gln Gly 
    210                 215                 220                 


Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Ile Met Leu Asp 
225                 230                 235                 240 


Trp Ala Leu Gly Lys Leu Phe Lys Asp Lys Phe Asp Tyr Leu Phe Phe 
                245                 250                 255     


Ile His Cys Arg Glu Val Ser Leu Arg Ala Pro Lys Ser Leu Ala Asp 
            260                 265                 270         


Leu Ile Ile Ser Cys Trp Pro Asp Pro Asn Pro Pro Val Cys Lys Ile 
        275                 280                 285             


Leu Cys Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe Asp Glu 
    290                 295                 300                 


Leu Gln Gly Ala Phe Asp Glu His Ile Glu Glu Val Cys Thr Asp Trp 
305                 310                 315                 320 


Gln Lys Ala Val Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile Arg Lys 
                325                 330                 335     


Lys Leu Leu Pro Lys Ala Ser Leu Leu Ile Thr Thr Arg Pro Val Ala 
            340                 345                 350         


Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val Glu Ile 
        355                 360                 365             


Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys Tyr Phe 
    370                 375                 380                 


Ser Asn Glu Leu Gln Ala Arg Glu Ala Phe Arg Leu Ile Gln Glu Asn 
385                 390                 395                 400 


Glu Ile Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp Ile Val 
                405                 410                 415     


Cys Thr Gly Leu Lys Gln Gln Met Glu Thr Gly Lys Ser Leu Ala Gln 
            420                 425                 430         


Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser Ser Leu 
        435                 440                 445             


Leu Gln Ser Arg Gly Gly Ile Glu Glu His Leu Phe Ser Ala Tyr Leu 
    450                 455                 460                 


Pro Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln Lys Ile 
465                 470                 475                 480 


Leu Phe Glu Glu Cys Asp Leu Arg Lys His Gly Leu Gln Lys Thr Asp 
                485                 490                 495     


Val Ser Ala Phe Leu Arg Met Asn Val Phe Gln Lys Glu Val Asp Cys 
            500                 505                 510         


Glu Arg Phe Tyr Ser Phe Ser His Met Thr Phe Gln Glu Phe Phe Ala 
        515                 520                 525             


Ala Met Tyr Tyr Leu Leu Glu Glu Glu Glu Glu Gly Val Thr Val Arg 
    530                 535                 540                 


Lys Gly Pro Glu Gly Cys Ser Asp Leu Leu Asn Arg Asp Val Lys Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Val Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Arg Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Ser Ala Met Gly His Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Val Val Ser Ser Phe Cys Ile Lys Asn 
            660                 665                 670         


Cys His Arg Val Lys Thr Leu Ser Leu Gly Phe Leu His Asn Ser Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Lys Arg Gly Ser Gln Pro Leu Asp Gln Val 
    690                 695                 700                 


Gln Cys Val Phe Pro Asp Pro His Val Ala Cys Ser Ser Arg Leu Val 
705                 710                 715                 720 


Asn Cys Cys Leu Thr Ser Ser Phe Cys Arg Gly Leu Phe Ser Ser Leu 
                725                 730                 735     


Ser Thr Asn Gln Ser Leu Thr Glu Leu Asp Leu Ser Asp Asn Thr Leu 
            740                 745                 750         


Gly Asp Pro Gly Met Arg Val Leu Cys Glu Ala Leu Gln His Pro Gly 
        755                 760                 765             


Cys Asn Ile Gln Arg Leu Trp Leu Gly Arg Cys Gly Leu Thr His Gln 
    770                 775                 780                 


Cys Cys Phe Asn Ile Ser Ser Val Leu Ser Ser Ser Gln Lys Leu Val 
785                 790                 795                 800 


Glu Leu Asp Leu Ser Asp Asn Ala Leu Gly Asp Phe Gly Val Arg Leu 
                805                 810                 815     


Leu Cys Val Gly Leu Lys His Leu Leu Cys Asn Leu Gln Lys Leu Trp 
            820                 825                 830         


Leu Val Ser Cys Cys Leu Thr Ser Ala Cys Cys Gln Asp Leu Ala Leu 
        835                 840                 845             


Val Leu Ser Ser Asn His Ser Leu Thr Arg Leu Tyr Ile Gly Glu Asn 
    850                 855                 860                 


Ala Leu Gly Asp Ser Gly Val Gln Val Leu Cys Glu Lys Met Lys Asp 
865                 870                 875                 880 


Pro Gln Cys Asn Leu Gln Lys Leu Gly Leu Val Asn Ser Gly Leu Thr 
                885                 890                 895     


Ser Leu Cys Cys Ser Ala Leu Thr Ser Val Leu Lys Thr Asn Gln Asn 
            900                 905                 910         


Leu Thr His Leu Tyr Leu Arg Ser Asn Ala Leu Gly Asp Met Gly Leu 
        915                 920                 925             


Lys Leu Leu Cys Glu Gly Leu Leu His Pro Asp Cys Lys Leu Gln Met 
    930                 935                 940                 


Leu Glu Leu Asp Asn Cys Ser Leu Thr Ser His Ser Cys Trp Asp Leu 
945                 950                 955                 960 


Ser Thr Ile Leu Thr His Asn Gln Ser Leu Arg Lys Leu Asn Leu Ser 
                965                 970                 975     


Asn Asn Asp Leu Gly Asp Leu Cys Val Val Thr Leu Cys Glu Val Leu 
            980                 985                 990         


Lys Gln Gln Gly Cys Leu Leu Gln  Ser Leu Gln Leu Gly  Glu Met Tyr 
        995                 1000                 1005             


Leu Asn  Cys Glu Thr Lys Arg  Thr Leu Glu Ala Leu  Gln Glu Glu 
    1010                 1015                 1020             


Lys Pro  Glu Leu Thr Val Val  Phe Glu Ile Ser Trp  
    1025                 1030                 1035 


<210>  25
<211>  1031
<212>  PRT
<213>  Bos taurus

<400>  25

Met Arg Met Val Ser Val Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Ile Asp Phe Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Ser Gln Lys Gly Cys Thr Ser Ile Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Lys Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Glu Glu Pro Glu Trp Glu Asn 
                85                  90                  95      


Ala Asn Ile Ser Val Leu Ser Gln Glu Glu Ser Leu Glu Glu Glu Trp 
            100                 105                 110         


Met Gly Leu Leu Gly Tyr Leu Ser Arg Ile Ser Ile Cys Arg Lys Lys 
        115                 120                 125             


Lys Asp Tyr Cys Lys Lys Tyr Arg Lys Tyr Val Arg Ser Lys Phe Gln 
    130                 135                 140                 


Cys Ile Lys Asp Arg Asn Ala Arg Leu Gly Glu Ser Val Asn Leu Asn 
145                 150                 155                 160 


Lys Arg Phe Thr Arg Leu Arg Leu Ile Lys Glu His Arg Ser Gln Gln 
                165                 170                 175     


Glu Arg Glu His Glu Leu Leu Ala Ile Gly Arg Thr Trp Ala Lys Ile 
            180                 185                 190         


Gln Asp Ser Pro Val Ser Ser Val Asn Leu Glu Leu Leu Phe Asp Pro 
        195                 200                 205             


Glu Asp Gln His Ser Glu Pro Val His Thr Val Val Phe Gln Gly Ala 
    210                 215                 220                 


Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Ile Met Leu Asp Trp 
225                 230                 235                 240 


Ala Ser Glu Lys Leu Tyr Gln Asp Arg Phe Asp Tyr Leu Phe Tyr Ile 
                245                 250                 255     


His Cys Arg Glu Val Ser Leu Gly Thr Gln Arg Ser Leu Gly Asp Leu 
            260                 265                 270         


Ile Ala Ser Cys Cys Pro Gly Pro Asn Pro Pro Ile Gly Lys Ile Val 
        275                 280                 285             


Ser Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe Asp Glu Leu 
    290                 295                 300                 


Gln Gly Ala Phe Asp Glu His Thr Glu Ala Leu Cys Thr Asn Trp Arg 
305                 310                 315                 320 


Lys Val Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile Arg Lys Arg 
                325                 330                 335     


Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro Val Ala Leu 
            340                 345                 350         


Glu Lys Leu Gln His Leu Leu Gly Gln Ala Arg His Val Glu Ile Leu 
        355                 360                 365             


Gly Phe Ser Glu Ala Arg Arg Lys Glu Tyr Phe Leu Lys Tyr Phe Ser 
    370                 375                 380                 


Asp Glu Gln Gln Ala Arg Glu Ala Phe Arg Leu Ile Gln Glu Asn Glu 
385                 390                 395                 400 


Ile Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp Ile Val Cys 
                405                 410                 415     


Thr Gly Leu Lys Gln Gln Met Asp Ser Gly Lys Ser Leu Ala Arg Thr 
            420                 425                 430         


Ser Lys Thr Thr Thr Ala Val Tyr Ile Phe Phe Leu Ser Ser Leu Leu 
        435                 440                 445             


Gln Ser Gln Gly Gly Ser Gln Glu Asn His Asn Ser Ala Thr Leu Trp 
    450                 455                 460                 


Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln Lys Ile Leu 
465                 470                 475                 480 


Phe Gln Glu Cys Asp Leu Arg Asn His Gly Leu Gln Lys Ala Asp Val 
                485                 490                 495     


Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val Asp Cys Glu 
            500                 505                 510         


Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe Phe Ala Ala 
        515                 520                 525             


Met Tyr Tyr Leu Leu Glu Glu Asp Asn His Gly Glu Met Arg Asn Thr 
    530                 535                 540                 


Pro Gln Ala Cys Ser Lys Leu Pro Asn Arg Asp Val Lys Val Leu Leu 
545                 550                 555                 560 


Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val Val Arg 
                565                 570                 575     


Phe Leu Phe Gly Leu Ile Asn Gln Glu Arg Thr Ser Tyr Leu Glu Lys 
            580                 585                 590         


Lys Leu Ser Cys Lys Ile Ser Gln Lys Ile Arg Leu Glu Leu Leu Lys 
        595                 600                 605             


Trp Ile Glu Ala Lys Ala Asn Ala Lys Thr Leu Gln Ile Glu Pro Ser 
    610                 615                 620                 


Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu Asp Phe 
625                 630                 635                 640 


Val Gln Arg Ala Met Ser His Phe Pro Lys Ile Glu Ile Lys Leu Ser 
                645                 650                 655     


Thr Arg Met Asp His Val Val Ser Ser Phe Cys Ile Glu Asn Cys Arg 
            660                 665                 670         


His Val Glu Ser Leu Ser Leu Arg Leu Leu His Asn Ser Pro Lys Glu 
        675                 680                 685             


Glu Glu Glu Glu Glu Glu Val Arg His Ser His Met Asp Arg Ser Val 
    690                 695                 700                 


Leu Ser Asp Phe Glu Val Ala Tyr Ser Gln Gly Leu Val Asn Tyr Leu 
705                 710                 715                 720 


Thr Ser Ser Ile Cys Arg Gly Ile Phe Ser Val Leu Ser Asn Asn Trp 
                725                 730                 735     


Asn Leu Thr Glu Leu Asn Leu Ser Gly Asn Thr Leu Gly Asp Pro Gly 
            740                 745                 750         


Met Asn Val Leu Cys Glu Thr Leu Gln Gln Pro Gly Cys Asn Ile Arg 
        755                 760                 765             


Arg Leu Trp Leu Gly Gln Cys Cys Leu Ser His Gln Cys Cys Phe Asn 
    770                 775                 780                 


Ile Ser Ser Val Leu Ser Asn Asn Gln Lys Leu Val Glu Leu Asp Leu 
785                 790                 795                 800 


Ser His Asn Ala Leu Gly Asp Phe Gly Ile Arg Leu Leu Cys Val Gly 
                805                 810                 815     


Leu Arg His Leu Phe Cys Asn Leu Lys Lys Leu Trp Leu Val Ser Cys 
            820                 825                 830         


Cys Leu Thr Ser Ala Ser Cys Glu Asp Leu Ala Ser Val Leu Ser Thr 
        835                 840                 845             


Asn His Ser Leu Thr Arg Leu Tyr Leu Gly Glu Asn Ala Leu Gly Asp 
    850                 855                 860                 


Ser Gly Val Gly Ile Leu Cys Glu Lys Val Lys Asn Pro His Cys Asn 
865                 870                 875                 880 


Leu Gln Lys Leu Gly Leu Val Asn Ser Gly Leu Thr Ser Gly Cys Cys 
                885                 890                 895     


Pro Ala Leu Ser Ser Val Leu Ser Thr Asn Gln Asn Leu Thr His Leu 
            900                 905                 910         


Tyr Leu Gln Gly Asn Ala Leu Gly Asp Met Gly Val Lys Leu Leu Cys 
        915                 920                 925             


Glu Gly Leu Leu His Arg Asn Cys Lys Leu Gln Val Leu Glu Leu Asp 
    930                 935                 940                 


Asn Cys Ser Leu Thr Ser His Cys Cys Trp Asp Leu Ser Thr Leu Leu 
945                 950                 955                 960 


Thr Ser Asn Gln Ser Leu Arg Lys Leu Cys Leu Gly Asn Asn Asp Leu 
                965                 970                 975     


Gly Asp Leu Gly Val Met Leu Leu Cys Glu Val Leu Lys Gln Gln Gly 
            980                 985                 990         


Cys Leu Leu Lys Ser Leu Arg Leu  Cys Glu Met Tyr Phe  Asn Tyr Asp 
        995                 1000                 1005             


Thr Lys  Arg Ala Leu Glu Thr  Leu Gln Glu Glu Lys  Pro Glu Leu 
    1010                 1015                 1020             


Thr Ile  Val Phe Glu Pro Ser  Arg 
    1025                 1030     


<210>  26
<211>  1027
<212>  PRT
<213>  Equus caballus

<400>  26

Met Ala Ser Val Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp Leu Glu 
1               5                   10                  15      


Asp Ala Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr Pro Pro 
            20                  25                  30          


Gln Lys Gly Cys Thr Arg Pro Pro Arg Gly Gln Thr Glu Lys Ala Asp 
        35                  40                  45              


Pro Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu Glu Lys 
    50                  55                  60                  


Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg Arg Asp 
65                  70                  75                  80  


Leu His Glu Lys Ala Lys Leu Glu Glu Pro Glu Trp Ala His Ser Cys 
                85                  90                  95      


Cys Tyr Arg Ser His Leu Ile Cys Gln Glu Glu Ser Ile Glu Glu Glu 
            100                 105                 110         


Trp Ile Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser Ile Cys Lys Lys 
        115                 120                 125             


Lys Lys Asp Tyr Cys Lys Lys Tyr Arg Lys His Val Arg Ser Arg Phe 
    130                 135                 140                 


Gln Cys Ile Lys Asp Arg Asn Ala Arg Leu Gly Glu Ser Val Asn Leu 
145                 150                 155                 160 


Asn Lys Arg Tyr Thr Arg Leu Cys Leu Leu Lys Glu His Arg Ser Gln 
                165                 170                 175     


Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Arg Thr Ser Pro Lys 
            180                 185                 190         


Thr Gln Asp Cys Pro Met Ser Ser Met Asn Leu Glu Leu Leu Phe Glu 
        195                 200                 205             


Pro Asp Asp Gln His Ser Glu Pro Val His Thr Val Val Phe Gln Gly 
    210                 215                 220                 


Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Ile Met Leu Asp 
225                 230                 235                 240 


Trp Ala Ser Glu Lys Leu Tyr Lys Asn Arg Phe Asp Tyr Leu Phe Tyr 
                245                 250                 255     


Ile His Cys Arg Glu Val Ser Leu Gly Thr Arg Arg Ser Leu Gly Asp 
            260                 265                 270         


Leu Ile Val Ser Cys Cys Pro Asp Pro Lys Pro Pro Ile Gly Lys Ile 
        275                 280                 285             


Leu Ser Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe Asp Glu 
    290                 295                 300                 


Leu Gln Gly Ala Phe Asp Glu His Thr Glu Ala Leu Cys Thr Asp Trp 
305                 310                 315                 320 


Gln Lys Val Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile Arg Lys 
                325                 330                 335     


Arg Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro Val Ala 
            340                 345                 350         


Leu Glu Lys Leu Gln His Leu Leu Asp Arg Pro Arg His Val Glu Ile 
        355                 360                 365             


Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys Tyr Phe 
    370                 375                 380                 


Ser Asp Glu Gln Gln Ala His Glu Ala Phe Arg Leu Ile Gln Glu Asn 
385                 390                 395                 400 


Glu Ile Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp Ile Val 
                405                 410                 415     


Cys Thr Gly Leu Lys Gln Gln Met Asp Ser Gly Lys Ser Leu Ala Gln 
            420                 425                 430         


Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser Ser Leu 
        435                 440                 445             


Leu Gln Ser Arg Gly Glu Ser Gln Lys Gln His Leu Ser Ala Asn Val 
    450                 455                 460                 


Arg Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln Lys Ile 
465                 470                 475                 480 


Leu Phe Glu Glu Ser Asp Leu Arg Lys His Gly Leu Gln Arg Ala Asp 
                485                 490                 495     


Ala Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val Asp Cys 
            500                 505                 510         


Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe Phe Ala 
        515                 520                 525             


Ala Met Tyr Tyr Leu Leu Glu Asp Glu Glu Gln Gly Ser Val Arg Asn 
    530                 535                 540                 


Met Pro Trp Gly Arg Ser Asn Leu Pro Asn Arg Asp Val Ser Val Leu 
545                 550                 555                 560 


Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val Val 
                565                 570                 575     


Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu Glu 
            580                 585                 590         


Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu Leu 
        595                 600                 605             


Lys Trp Ile Ser Ala Lys Ala Glu Val Lys Lys Leu Gln Thr Gln Pro 
    610                 615                 620                 


Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu Asp 
625                 630                 635                 640 


Phe Val Arg Arg Ala Met Gly Tyr Phe Pro Lys Ile Glu Ile Ser Leu 
                645                 650                 655     


Ser Thr Arg Met Asp His Val Val Ser Ser Phe Cys Ile Glu Asn Cys 
            660                 665                 670         


Arg Ser Val Glu Ser Leu Ser Leu Arg Leu Leu Tyr Asn Ser Pro Lys 
        675                 680                 685             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Gly Ile Asp Phe Leu 
    690                 695                 700                 


Phe Ser Pro Ser Ser Phe Leu Pro Ile Ser Arg Leu Val Asn Cys Ser 
705                 710                 715                 720 


Leu Thr Ser Ser Phe Cys Gln Ser Leu Phe Ser Ala Leu Ser Thr Asn 
                725                 730                 735     


Trp Ser Leu Thr Glu Leu Asn Leu Gly Asp Asn Thr Leu Gly Asp Ser 
            740                 745                 750         


Gly Met Lys Val Leu Cys Asp Met Leu Gln His Pro Gly Cys Asn Ile 
        755                 760                 765             


Gln Arg Leu Cys Ala Thr His Trp Gly Leu Lys Gln Gln Lys Phe Thr 
    770                 775                 780                 


Phe Ser His Leu Ile Thr Ser Leu Lys Ala Leu Ser Pro Asn Thr Val 
785                 790                 795                 800 


Thr Phe Ser Gly Cys Gly Glu Thr Gly Thr Thr Leu His Cys Gly Trp 
                805                 810                 815     


Lys Cys Lys Met Val Gln Leu Leu Leu Val Gly Cys Cys Leu Thr Ser 
            820                 825                 830         


Ala Cys Cys Glu Asp Leu Ala Ser Val Leu Ser Thr Ser His Ser Leu 
        835                 840                 845             


Ile Arg Leu Tyr Leu Gly Glu Asn Ala Leu Gly Asp Ser Gly Val Gly 
    850                 855                 860                 


Ile Leu Cys Glu Lys Ala Lys His Pro Arg Cys Asn Leu Gln Val Leu 
865                 870                 875                 880 


Gly Leu Val Asn Ser Gly Leu Thr Ser Gly Cys Cys Pro Ala Leu Ser 
                885                 890                 895     


Ser Val Leu Ser Ala Asn His Asn Leu Lys Gln Leu Tyr Leu Arg Gly 
            900                 905                 910         


Asn Ala Leu Gly Asp Thr Gly Val Lys Leu Leu Cys Glu Gly Leu Ser 
        915                 920                 925             


His Pro Asn Cys Lys Leu Gln Met Leu Glu Leu Asp Ser Cys Ser Leu 
    930                 935                 940                 


Thr Ser His Cys Cys Trp Asp Leu Ser Thr Leu Leu Thr Ser Asn Gln 
945                 950                 955                 960 


Ser Leu Arg Glu Leu Ser Leu Gly Gly Asn Asp Leu Gly Asp Leu Gly 
                965                 970                 975     


Val Met Leu Leu Cys Glu Val Leu Lys Gln Gln Gly Cys Leu Leu Arg 
            980                 985                 990         


Ser Leu Gly Leu Cys Glu Met Tyr  Phe Asn Tyr Glu Thr  Lys Cys Ala 
        995                 1000                 1005             


Leu Glu  Thr Leu Gln Glu Glu  Lys Pro Glu Leu Ser  Val Val Phe 
    1010                 1015                 1020             


Glu Pro  Ser Trp 
    1025         


<210>  27
<211>  722
<212>  PRT
<213>  Sus scrofa

<400>  27

Met Ser Met Ala Ser Val Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Phe Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Ser Gln Lys Gly Cys Ile Ser Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Thr Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Glu Trp Val Pro 
                85                  90                  95      


Asp Asn Ala Asn Leu Ser Val Ile Ser Gln Glu Glu Ser Leu Glu Glu 
            100                 105                 110         


Glu Trp Met Gly Leu Leu Gly Tyr Leu Ser Arg Ile Ser Ile Cys Lys 
        115                 120                 125             


Lys Lys Lys Asp Tyr Cys Lys Lys Tyr Arg Lys His Val Arg Ser Arg 
    130                 135                 140                 


Phe Gln Cys Ile Lys Asp Arg Asn Ala Arg Leu Gly Glu Ser Val Asn 
145                 150                 155                 160 


Leu Asn Lys Arg Phe Thr Arg Leu Arg Leu Ile Lys Glu His Arg Ser 
                165                 170                 175     


Gln Gln Glu Arg Glu His Glu Leu Leu Ala Ile Gly Arg Thr Ser Ala 
            180                 185                 190         


Lys Met Gln Asp Gly Pro Val Ser Ser Leu Asn Leu Glu Leu Leu Phe 
        195                 200                 205             


Asp Pro Glu Asp Gln His Ser Glu Pro Val His Thr Val Val Phe Gln 
    210                 215                 220                 


Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Ile Met Leu 
225                 230                 235                 240 


Asp Trp Ala Ser Glu Lys Leu Tyr Gln Glu Lys Phe Asp Tyr Leu Phe 
                245                 250                 255     


Tyr Ile His Cys Arg Glu Val Ser Leu Gly Thr Arg Arg Ser Leu Gly 
            260                 265                 270         


Asp Leu Ile Ala Ser Cys Cys Pro Gly Pro Asn Pro Pro Ile Gly Lys 
        275                 280                 285             


Ile Val Ser Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe Asp 
    290                 295                 300                 


Glu Leu Gln Gly Ala Phe Asp Glu Arg Thr Glu Ala Leu Cys Thr Asn 
305                 310                 315                 320 


Trp Gln Lys Val Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile Arg 
                325                 330                 335     


Lys Arg Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro Val 
            340                 345                 350         


Ala Leu Glu Lys Leu Gln His Leu Leu Gly Arg Ala Arg His Val Glu 
        355                 360                 365             


Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys Tyr 
    370                 375                 380                 


Phe Ser Asp Glu Gln Gln Ala Arg Glu Ala Phe Arg Leu Ile Gln Glu 
385                 390                 395                 400 


Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp Ile 
                405                 410                 415     


Val Cys Thr Gly Leu Lys Gln Gln Met Asp Ser Gly Lys Ser Leu Ala 
            420                 425                 430         


Arg Thr Ser Lys Thr Thr Thr Ala Val Tyr Ile Phe Phe Leu Ser Thr 
        435                 440                 445             


Leu Leu Gln Ser Gln Glu Gly Ser Gln Asp His His Val Ser Ala Thr 
    450                 455                 460                 


Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln Lys 
465                 470                 475                 480 


Ile Leu Phe Glu Glu Cys Asp Leu Arg Asn His Gly Leu Gln Lys Ala 
                485                 490                 495     


Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val Asp 
            500                 505                 510         


Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe Phe 
        515                 520                 525             


Ala Ala Met Tyr Tyr Leu Leu Glu Lys Glu Asp Gln Gly Glu Met Arg 
    530                 535                 540                 


Asn Val Pro Arg Ser Cys Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Lys Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Ala Lys Ala Lys Ala Lys Lys Leu Gln Ile Glu 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Lys Ala Met Gly His Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Val Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys Arg His Val Glu Ser Leu Ser Leu Arg Leu Leu His Asn Ser Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Glu Ile Glu Glu Glu Asp Val Gln His 
    690                 695                 700                 


Ser Asp Val Asp Asn Cys Ile Leu Ser Glu Ser His Val Ala Tyr Ser 
705                 710                 715                 720 


Gln Arg 
        


<210>  28
<211>  1035
<212>  PRT
<213>  Rattus norvegicus

<400>  28

Met Lys Met Met Ser Val Arg Cys Lys Leu Ala Gln Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Glu Lys Gly Cys Val Pro Ile Pro Arg Gly Gln Met Glu Lys 
        35                  40                  45              


Ala Asp His Leu Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Gly Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Trp Glu Lys Ala Lys Lys Asp Gln Pro Glu Trp Asn Asp 
                85                  90                  95      


Ala Cys Thr Ser Asn Leu Ser Met Val Cys Gln Glu Asp Ser Leu Glu 
            100                 105                 110         


Glu Glu Trp Ile Gly Leu Leu Gly Tyr Leu Ser Arg Ile Ser Ile Cys 
        115                 120                 125             


Lys Lys Lys Lys Asp Tyr Cys Lys Ile Tyr Arg Arg His Val Arg Ser 
    130                 135                 140                 


Arg Phe Tyr Ser Ile Lys Asp Arg Asn Ala Arg Leu Gly Glu Ser Val 
145                 150                 155                 160 


Asp Leu Asn Arg Arg Tyr Thr Gln Leu Gln Leu Val Lys Glu His Pro 
                165                 170                 175     


Ser Lys Gln Glu Arg Glu His Glu Leu Leu Thr Ile Gly Arg Thr Lys 
            180                 185                 190         


Met Trp Asp Arg Pro Met Ser Ser Leu Lys Leu Glu Leu Leu Phe Glu 
        195                 200                 205             


Pro Glu Asp Glu His Leu Glu Pro Val His Thr Val Val Phe Gln Gly 
    210                 215                 220                 


Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Ile Met Leu Asp 
225                 230                 235                 240 


Trp Ala Leu Gly Lys Leu Phe Lys Asp Lys Phe Asp Tyr Leu Phe Phe 
                245                 250                 255     


Ile His Cys Arg Glu Val Ser Leu Arg Ala Pro Lys Ser Leu Ala Asp 
            260                 265                 270         


Leu Ile Ile Ser Cys Trp Pro Asp Pro Asn Pro Pro Val Cys Lys Ile 
        275                 280                 285             


Leu Cys Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe Asp Glu 
    290                 295                 300                 


Leu Gln Gly Ala Phe Asp Glu His Ile Glu Glu Val Cys Thr Asp Trp 
305                 310                 315                 320 


Gln Lys Ala Val Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile Arg Lys 
                325                 330                 335     


Lys Leu Leu Pro Lys Ala Ser Leu Leu Ile Thr Thr Arg Pro Val Ala 
            340                 345                 350         


Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val Glu Ile 
        355                 360                 365             


Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys Tyr Phe 
    370                 375                 380                 


Ser Asn Glu Leu Gln Ala Arg Glu Ala Phe Arg Leu Ile Gln Glu Asn 
385                 390                 395                 400 


Glu Ile Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp Ile Val 
                405                 410                 415     


Cys Thr Gly Leu Lys Gln Gln Met Glu Thr Gly Lys Ser Leu Ala Gln 
            420                 425                 430         


Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser Ser Leu 
        435                 440                 445             


Leu Gln Ser Arg Gly Gly Ile Glu Glu His Leu Phe Ser Ala Tyr Leu 
    450                 455                 460                 


Pro Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln Lys Ile 
465                 470                 475                 480 


Leu Phe Glu Glu Cys Asp Leu Arg Lys His Gly Leu Gln Lys Thr Asp 
                485                 490                 495     


Val Ser Ala Phe Leu Arg Met Asn Val Phe Gln Lys Glu Val Asp Cys 
            500                 505                 510         


Glu Arg Phe Tyr Ser Phe Ser His Met Thr Phe Gln Glu Phe Phe Ala 
        515                 520                 525             


Ala Met Tyr Tyr Leu Leu Glu Glu Glu Glu Glu Gly Val Thr Val Arg 
    530                 535                 540                 


Lys Gly Pro Glu Gly Cys Ser Asp Leu Leu Asn Arg Asp Val Lys Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Val Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Arg Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Ser Ala Met Gly His Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Val Val Ser Ser Phe Cys Ile Lys Asn 
            660                 665                 670         


Cys His Arg Val Lys Thr Leu Ser Leu Gly Phe Leu His Asn Ser Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Lys Arg Gly Ser Gln Pro Leu Asp Gln Val 
    690                 695                 700                 


Gln Cys Val Phe Pro Asp Pro His Val Ala Cys Ser Ser Arg Leu Val 
705                 710                 715                 720 


Asn Cys Cys Leu Thr Ser Ser Phe Cys Arg Gly Leu Phe Ser Ser Leu 
                725                 730                 735     


Ser Thr Asn Gln Ser Leu Thr Glu Leu Asp Leu Ser Asp Asn Thr Leu 
            740                 745                 750         


Gly Asp Pro Gly Met Arg Val Leu Cys Glu Ala Leu Gln His Pro Gly 
        755                 760                 765             


Cys Asn Ile Gln Arg Leu Trp Leu Gly Arg Cys Gly Leu Thr His Gln 
    770                 775                 780                 


Cys Cys Phe Asn Ile Ser Ser Val Leu Ser Ser Ser Gln Lys Leu Val 
785                 790                 795                 800 


Glu Leu Asp Leu Ser Asp Asn Ala Leu Gly Asp Phe Gly Val Arg Leu 
                805                 810                 815     


Leu Cys Val Gly Leu Lys His Leu Leu Cys Asn Leu Gln Lys Leu Trp 
            820                 825                 830         


Leu Val Ser Cys Cys Leu Thr Ser Ala Cys Cys Gln Asp Leu Ala Leu 
        835                 840                 845             


Val Leu Ser Ser Asn His Ser Leu Thr Arg Leu Tyr Ile Gly Glu Asn 
    850                 855                 860                 


Ala Leu Gly Asp Ser Gly Val Gln Val Leu Cys Glu Lys Met Lys Asp 
865                 870                 875                 880 


Pro Gln Cys Asn Leu Gln Lys Leu Gly Leu Val Asn Ser Gly Leu Thr 
                885                 890                 895     


Ser Leu Cys Cys Ser Ala Leu Thr Ser Val Leu Lys Thr Asn Gln Asn 
            900                 905                 910         


Leu Thr His Leu Tyr Leu Arg Ser Asn Ala Leu Gly Asp Met Gly Leu 
        915                 920                 925             


Lys Leu Leu Cys Glu Gly Leu Leu His Pro Asp Cys Lys Leu Gln Met 
    930                 935                 940                 


Leu Glu Leu Asp Asn Cys Ser Leu Thr Ser His Ser Cys Trp Asp Leu 
945                 950                 955                 960 


Ser Thr Ile Leu Thr His Asn Gln Ser Leu Arg Lys Leu Asn Leu Ser 
                965                 970                 975     


Asn Asn Asp Leu Gly Asp Leu Cys Val Val Thr Leu Cys Glu Val Leu 
            980                 985                 990         


Lys Gln Gln Gly Cys Leu Leu Gln  Ser Leu Gln Leu Gly  Glu Met Tyr 
        995                 1000                 1005             


Leu Asn  Cys Glu Thr Lys Arg  Thr Leu Glu Ala Leu  Gln Glu Glu 
    1010                 1015                 1020             


Lys Pro  Glu Leu Thr Val Val  Phe Glu Ile Ser Trp  
    1025                 1030                 1035 


<210>  29
<211>  1046
<212>  PRT
<213>  Oryctolagus cuniculu

<400>  29

Met Ala Gly Thr Arg Cys Lys Leu Ala Gln Tyr Leu Glu Asp Leu Glu 
1               5                   10                  15      


Glu Leu Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr Pro Pro 
            20                  25                  30          


Asp Gln Gly Cys Ile Pro Leu Pro Arg Gly Gln Ala Ala Arg Ala Asp 
        35                  40                  45              


Pro Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu Glu Lys 
    50                  55                  60                  


Ala Trp Ala Met Ala Leu Trp Ile Phe Thr Ala Ile Asn Arg Arg Asp 
65                  70                  75                  80  


Leu Tyr Glu Arg Ala Lys Arg Asp Glu Pro Val Trp Glu Pro Ala His 
                85                  90                  95      


Val Ser Asn Ala Thr Val Ile Cys His Glu Glu Ile Ile Glu Glu Glu 
            100                 105                 110         


Arg Met Gly Ile Leu Gly His Leu Ser Arg Ile Ser Ile Cys Thr Lys 
        115                 120                 125             


Arg Lys Asp Tyr Cys Lys Lys Tyr Arg Lys His Val Arg Ser Arg Phe 
    130                 135                 140                 


Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu Ser Val Asn Leu 
145                 150                 155                 160 


Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ala Lys Glu His Leu Ser Arg 
                165                 170                 175     


Gln Glu Arg Glu Gln Glu Leu Val Ala Ile Gly Arg Thr His Val Trp 
            180                 185                 190         


Asp Ser Pro Ala Ser Pro Val Arg Val Glu Leu Leu Phe Asp Ala Asp 
        195                 200                 205             


Glu Glu Cys Leu Glu Pro Val Arg Thr Val Val Leu Gln Gly Ala Ala 
    210                 215                 220                 


Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Ile Met Leu Asp Trp Ala 
225                 230                 235                 240 


Ser Gly Gln Leu Phe Gln Asp Arg Phe Asp Tyr Leu Phe Tyr Ile His 
                245                 250                 255     


Cys Arg Glu Met Ser Leu Gly Met His Arg Ser Leu Val Asp Leu Ile 
            260                 265                 270         


Ala Gly Cys Cys Ser Asp Pro Ser Pro Pro Val Ser Lys Met Leu His 
        275                 280                 285             


Arg Pro Ser Arg Val Leu Phe Leu Met Asp Gly Phe Asp Glu Leu Gln 
    290                 295                 300                 


Gly Ala Phe Asp Glu Ser Ser Gly Ala Leu Cys Ser Asp Trp Arg Val 
305                 310                 315                 320 


Ala Val Arg Gly Asp Val Leu Leu Gly Ser Leu Ile Arg Lys Lys Leu 
                325                 330                 335     


Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro Val Ala Leu Glu 
            340                 345                 350         


Lys Leu Gln His Leu Leu Asp Arg Pro Arg His Val Glu Val Leu Gly 
        355                 360                 365             


Phe Ser Glu Ala Arg Arg Lys Glu Tyr Phe Phe Lys Tyr Phe Leu Glu 
    370                 375                 380                 


Glu Ala Gln Ala Arg Glu Ala Phe Ser Leu Leu Gln Glu Asn Glu Val 
385                 390                 395                 400 


Leu Leu Ser Met Cys Cys Ile Pro Leu Val Cys Trp Ile Val Cys Thr 
                405                 410                 415     


Gly Leu Lys Gln Gln Met Gln Gly Gly Lys His Arg Ala Lys Thr Thr 
            420                 425                 430         


Thr Ser Lys Thr Thr Thr Ala Val Tyr Thr Phe Phe Leu Ser Ser Leu 
        435                 440                 445             


Leu Gln Ser Arg Gly Gly Ser Gln Glu Gln Arg Leu Ser Gly His Leu 
    450                 455                 460                 


Arg Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln Lys Ile 
465                 470                 475                 480 


Leu Phe Glu Glu Arg Asp Leu Arg Arg His Gly Leu Gln Glu Ala Glu 
                485                 490                 495     


Val Ser Ala Phe Leu Arg Met Ser Leu Phe Gln Lys Glu Val Asp Cys 
            500                 505                 510         


Glu Ala Phe Tyr Ser Phe Val His Leu Thr Phe Gln Glu Phe Phe Ala 
        515                 520                 525             


Ala Met Tyr Tyr Val Leu Glu Glu Glu Glu Glu Glu Lys Glu Glu Glu 
    530                 535                 540                 


Glu Gly Ala Gly Thr Gly Arg Ser Pro Pro Ala Arg Gly Leu Asp Leu 
545                 550                 555                 560 


Pro His Arg Asp Val Arg Val Leu Leu Glu Asn Tyr Gly Lys Phe Glu 
                565                 570                 575     


Lys Gly Tyr Leu Ile Phe Val Val Arg Phe Leu Phe Gly Leu Val Asn 
            580                 585                 590         


Gln Glu Arg Ala Ser Tyr Leu Glu Lys Lys Leu Ser Cys Lys Ile Ser 
        595                 600                 605             


Gln Gln Val Arg Pro Glu Leu Leu Arg Trp Ile Glu Thr Lys Ala Asn 
    610                 615                 620                 


Ala Lys Lys Leu Gln Ile Gln Pro Ser Gln Leu Glu Leu Phe Tyr Cys 
625                 630                 635                 640 


Leu Tyr Glu Met Gln Glu Glu Ala Phe Val Arg Glu Ala Met Gly His 
                645                 650                 655     


Phe Pro Arg Ile Glu Ile Asn Leu Ser Thr Arg Met Asp His Val Val 
            660                 665                 670         


Ser Ser Phe Cys Ile Gly Asn Cys His Ser Val Glu Ser Leu Ser Leu 
        675                 680                 685             


Gly Phe Leu His Asn Ser Pro Lys Glu Glu Glu Glu Glu Glu Glu Glu 
    690                 695                 700                 


Glu Glu Val Glu Ser Pro Leu Phe Asp Val Gly Cys Pro Asn Arg Gln 
705                 710                 715                 720 


Gly Pro His Ala Ala Cys Ser Trp Arg Leu Val Asn Ser Cys Leu Thr 
                725                 730                 735     


Ser Ser Phe Cys Arg Gly Leu Phe Ser Val Leu Ser Thr Asn Pro Ser 
            740                 745                 750         


Leu Thr Glu Leu Asp Leu Ser Asp Asn Ser Leu Gly Asp Pro Gly Met 
        755                 760                 765             


Arg Val Leu Cys Glu Ala Leu Gln His Pro Gly Cys Asn Ile Arg Arg 
    770                 775                 780                 


Leu Trp Leu Gly Arg Cys Gly Leu Ser His Gln Cys Cys Phe Asp Ile 
785                 790                 795                 800 


Ser Leu Val Leu Ser Gly Ser Gln Lys Leu Val Glu Leu Asp Leu Ser 
                805                 810                 815     


Asp Asn Ala Leu Gly Asp Phe Gly Val Arg Leu Leu Cys Val Gly Leu 
            820                 825                 830         


Arg His Leu Ser Cys Gln Leu Gln Lys Leu Trp Leu Val Ser Cys Cys 
        835                 840                 845             


Leu Thr Ser Met Cys Cys Gln Asp Leu Ala Ser Val Leu Ser Thr Asn 
    850                 855                 860                 


His Cys Leu Thr Arg Leu Tyr Leu Gly Glu Asn Thr Leu Gly Asp Tyr 
865                 870                 875                 880 


Gly Val Gly Leu Leu Cys Glu Lys Val Lys His Pro Gln Cys Asn Leu 
                885                 890                 895     


Gln Lys Leu Gly Leu Val Asn Ser Gly Leu Thr Ser Ala Cys Cys Ala 
            900                 905                 910         


Ala Leu Ser Ala Ala Leu Ser Thr Ser Arg Ser Leu Thr His Leu Tyr 
        915                 920                 925             


Leu Arg Gly Asn Ala Leu Gly Asp Ala Gly Val Lys Leu Leu Cys Glu 
    930                 935                 940                 


Gly Leu Leu His Pro Ser Cys Arg Leu Gln Met Leu Glu Leu Asp Ser 
945                 950                 955                 960 


Cys Ser Leu Thr Ser His Cys Cys Trp Asn Leu Cys Thr Ile Leu Thr 
                965                 970                 975     


Cys Ser Arg Ser Leu Arg Lys Leu Ser Leu Gly Asn Asn Asp Leu Gly 
            980                 985                 990         


Asp Leu Gly Val Met Met Leu Cys  Glu Val Leu Arg Gln  Pro Asp Cys 
        995                 1000                 1005             


Pro Leu  Gln Arg Leu Gln Leu  Cys Glu Met Tyr Phe  Asn Pro Glu 
    1010                 1015                 1020             


Thr Ile  His Ala Leu Glu Thr  Leu Arg Glu Glu Lys  Pro Ala Leu 
    1025                 1030                 1035             


Thr Val  Val Phe Glu Pro Ser  Trp 
    1040                 1045     


<210>  30
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  30

Thr Gly Gly Gly Cys Thr Gly Gly Ala Thr Gly Ala Ala Ala Gly Ala 
1               5                   10                  15      


Gly Ala Ala 
            


<210>  31
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  31

Gly Gly Thr Cys Cys Ala Cys Cys Thr Thr Gly Gly Ala Gly Ala Ala 
1               5                   10                  15      


Gly Thr Cys Thr Gly 
            20      


<210>  32
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  32

Gly Cys Gly Gly Ala Gly Gly Thr Gly Gly Gly Ala Gly Ala Thr Ala 
1               5                   10                  15      


Thr Gly 
        


<210>  33
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  33

Cys Gly Thr Ala Gly Ala Ala Gly Gly Thr Thr Thr Gly Gly Ala Ala 
1               5                   10                  15      


Cys Ala Gly Cys 
            20  


<210>  34
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  34

Gly Ala Thr Cys Thr Gly Gly Cys Ala Cys Cys Ala Cys Ala Cys Cys 
1               5                   10                  15      


Thr Thr Cys Thr 
            20  


<210>  35
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  35

Gly Gly Gly Gly Thr Gly Thr Thr Gly Ala Ala Gly Gly Thr Cys Thr 
1               5                   10                  15      


Cys Ala Ala Ala 
            20  


<210>  36
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  36

Gly Cys Ala Ala Cys Ala Gly Cys Ala Thr Cys Thr Thr Gly Cys Cys 
1               5                   10                  15      


Thr Gly Ala Thr 
            20  


<210>  37
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  37

Gly Thr Gly Cys Thr Ala Cys Thr Gly Gly Thr Cys Thr Cys Ala Cys 
1               5                   10                  15      


Thr Thr 
        


<210>  38
<211>  979
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Lys Met Ala Ser Thr Arg Cys Lys Leu Ala Arg Tyr Leu Glu Asp 
1               5                   10                  15      


Leu Glu Asp Val Asp Leu Lys Lys Phe Lys Met His Leu Glu Asp Tyr 
            20                  25                  30          


Pro Pro Gln Lys Gly Cys Ile Pro Leu Pro Arg Gly Gln Thr Glu Lys 
        35                  40                  45              


Ala Asp His Val Asp Leu Ala Thr Leu Met Ile Asp Phe Asn Gly Glu 
    50                  55                  60                  


Glu Lys Ala Trp Ala Met Ala Val Trp Ile Phe Ala Ala Ile Asn Arg 
65                  70                  75                  80  


Arg Asp Leu Tyr Glu Lys Ala Lys Arg Asp Glu Pro Lys Trp Gly Ser 
                85                  90                  95      


Asp Asn Ala Arg Val Ser Asn Pro Thr Val Ile Cys Gln Glu Asp Ser 
            100                 105                 110         


Ile Glu Glu Glu Trp Met Gly Leu Leu Glu Tyr Leu Ser Arg Ile Ser 
        115                 120                 125             


Ile Cys Lys Met Lys Lys Asp Tyr Arg Lys Lys Tyr Arg Lys Tyr Val 
    130                 135                 140                 


Arg Ser Arg Phe Gln Cys Ile Glu Asp Arg Asn Ala Arg Leu Gly Glu 
145                 150                 155                 160 


Ser Val Ser Leu Asn Lys Arg Tyr Thr Arg Leu Arg Leu Ile Lys Glu 
                165                 170                 175     


His Arg Ser Gln Gln Glu Arg Glu Gln Glu Leu Leu Ala Ile Gly Lys 
            180                 185                 190         


Thr Lys Thr Cys Glu Ser Pro Val Ser Pro Ile Lys Met Glu Leu Leu 
        195                 200                 205             


Phe Asp Pro Asp Asp Glu His Ser Glu Pro Val His Thr Val Val Phe 
    210                 215                 220                 


Gln Gly Ala Ala Gly Ile Gly Lys Thr Ile Leu Ala Arg Lys Met Met 
225                 230                 235                 240 


Leu Asp Trp Ala Ser Gly Thr Leu Tyr Gln Asp Arg Phe Asp Tyr Leu 
                245                 250                 255     


Phe Tyr Ile His Cys Arg Glu Val Ser Leu Val Thr Gln Arg Ser Leu 
            260                 265                 270         


Gly Asp Leu Ile Met Ser Cys Cys Pro Asp Pro Asn Pro Pro Ile His 
        275                 280                 285             


Lys Ile Val Arg Lys Pro Ser Arg Ile Leu Phe Leu Met Asp Gly Phe 
    290                 295                 300                 


Asp Glu Leu Gln Gly Ala Phe Asp Glu His Ile Gly Pro Leu Cys Thr 
305                 310                 315                 320 


Asp Trp Gln Lys Ala Glu Arg Gly Asp Ile Leu Leu Ser Ser Leu Ile 
                325                 330                 335     


Arg Lys Lys Leu Leu Pro Glu Ala Ser Leu Leu Ile Thr Thr Arg Pro 
            340                 345                 350         


Val Ala Leu Glu Lys Leu Gln His Leu Leu Asp His Pro Arg His Val 
        355                 360                 365             


Glu Ile Leu Gly Phe Ser Glu Ala Lys Arg Lys Glu Tyr Phe Phe Lys 
    370                 375                 380                 


Tyr Phe Ser Asp Glu Ala Gln Ala Arg Ala Ala Phe Ser Leu Ile Gln 
385                 390                 395                 400 


Glu Asn Glu Val Leu Phe Thr Met Cys Phe Ile Pro Leu Val Cys Trp 
                405                 410                 415     


Ile Val Cys Thr Gly Leu Lys Gln Gln Met Glu Ser Gly Lys Ser Leu 
            420                 425                 430         


Ala Gln Thr Ser Lys Thr Thr Thr Ala Val Tyr Val Phe Phe Leu Ser 
        435                 440                 445             


Ser Leu Leu Gln Pro Arg Gly Gly Ser Gln Glu His Gly Leu Cys Ala 
    450                 455                 460                 


His Leu Trp Gly Leu Cys Ser Leu Ala Ala Asp Gly Ile Trp Asn Gln 
465                 470                 475                 480 


Lys Ile Leu Phe Glu Glu Ser Asp Leu Arg Asn His Gly Leu Gln Lys 
                485                 490                 495     


Ala Asp Val Ser Ala Phe Leu Arg Met Asn Leu Phe Gln Lys Glu Val 
            500                 505                 510         


Asp Cys Glu Lys Phe Tyr Ser Phe Ile His Met Thr Phe Gln Glu Phe 
        515                 520                 525             


Phe Ala Ala Met Tyr Tyr Leu Leu Glu Glu Glu Lys Glu Gly Arg Thr 
    530                 535                 540                 


Asn Val Pro Gly Ser Arg Leu Lys Leu Pro Ser Arg Asp Val Thr Val 
545                 550                 555                 560 


Leu Leu Glu Asn Tyr Gly Lys Phe Glu Lys Gly Tyr Leu Ile Phe Val 
                565                 570                 575     


Val Arg Phe Leu Phe Gly Leu Val Asn Gln Glu Arg Thr Ser Tyr Leu 
            580                 585                 590         


Glu Lys Lys Leu Ser Cys Lys Ile Ser Gln Gln Ile Arg Leu Glu Leu 
        595                 600                 605             


Leu Lys Trp Ile Glu Val Lys Ala Lys Ala Lys Lys Leu Gln Ile Gln 
    610                 615                 620                 


Pro Ser Gln Leu Glu Leu Phe Tyr Cys Leu Tyr Glu Met Gln Glu Glu 
625                 630                 635                 640 


Asp Phe Val Gln Arg Ala Met Asp Tyr Phe Pro Lys Ile Glu Ile Asn 
                645                 650                 655     


Leu Ser Thr Arg Met Asp His Met Val Ser Ser Phe Cys Ile Glu Asn 
            660                 665                 670         


Cys His Arg Val Glu Ser Leu Ser Leu Gly Phe Leu His Asn Met Pro 
        675                 680                 685             


Lys Glu Glu Glu Glu Glu Glu Lys Glu Gly Arg His Leu Asp Met Val 
    690                 695                 700                 


Gln Cys Val Leu Pro Ser Ser Ser His Ala Ala Cys Ser His Gly Leu 
705                 710                 715                 720 


Gly Arg Cys Gly Leu Ser His Glu Cys Cys Phe Asp Ile Ser Leu Val 
                725                 730                 735     


Leu Ser Ser Asn Gln Lys Leu Val Glu Leu Asp Leu Ser Asp Asn Ala 
            740                 745                 750         


Leu Gly Asp Phe Gly Ile Arg Leu Leu Cys Val Gly Leu Lys His Leu 
        755                 760                 765             


Leu Cys Asn Leu Lys Lys Leu Trp Leu Val Ser Cys Cys Leu Thr Ser 
    770                 775                 780                 


Ala Cys Cys Gln Asp Leu Ala Ser Val Leu Ser Thr Ser His Ser Leu 
785                 790                 795                 800 


Thr Arg Leu Tyr Val Gly Glu Asn Ala Leu Gly Asp Ser Gly Val Ala 
                805                 810                 815     


Ile Leu Cys Glu Lys Ala Lys Asn Pro Gln Cys Asn Leu Gln Lys Leu 
            820                 825                 830         


Gly Leu Val Asn Ser Gly Leu Thr Ser Val Cys Cys Ser Ala Leu Ser 
        835                 840                 845             


Ser Val Leu Ser Thr Asn Gln Asn Leu Thr His Leu Tyr Leu Arg Gly 
    850                 855                 860                 


Asn Thr Leu Gly Asp Lys Gly Ile Lys Leu Leu Cys Glu Gly Leu Leu 
865                 870                 875                 880 


His Pro Asp Cys Lys Leu Gln Val Leu Glu Leu Asp Asn Cys Asn Leu 
                885                 890                 895     


Thr Ser His Cys Cys Trp Asp Leu Ser Thr Leu Leu Thr Ser Ser Gln 
            900                 905                 910         


Ser Leu Arg Lys Leu Ser Leu Gly Asn Asn Asp Leu Gly Asp Leu Gly 
        915                 920                 925             


Val Met Met Phe Cys Glu Val Leu Lys Gln Gln Ser Cys Leu Leu Gln 
    930                 935                 940                 


Asn Leu Gly Leu Ser Glu Met Tyr Phe Asn Tyr Glu Thr Lys Ser Ala 
945                 950                 955                 960 


Leu Glu Thr Leu Gln Glu Glu Lys Pro Glu Leu Thr Val Val Phe Glu 
                965                 970                 975     


Pro Ser Trp 
            


<210>  39
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Asp Phe Leu Arg Asn Leu Phe Ser Gln Thr Leu Ser Leu Gly Ser 
1               5                   10                  15      


Gln Lys Glu Arg Leu Leu Asp Glu Leu Thr Leu Glu Gly Val Ala Arg 
            20                  25                  30          


Tyr Met Gln Ser Glu Arg Cys Arg Arg Val Ile Cys Leu Val Gly Ala 
        35                  40                  45              


Gly Ile Ser Thr Ser Ala Gly Ile Pro Asp Phe Arg Ser Pro Ser Thr 
    50                  55                  60                  


Gly Leu Tyr Asp Asn Leu Glu Lys Tyr His Leu Pro Tyr Pro Glu Ala 
65                  70                  75                  80  


Ile Phe Glu Ile Ser Tyr Phe Lys Lys His Pro Glu Pro Phe Phe Ala 
                85                  90                  95      


Leu Ala Lys Glu Leu Tyr Pro Gly Gln Phe Lys Pro Thr Ile Cys His 
            100                 105                 110         


Tyr Phe Met Arg Leu Leu Lys Asp Lys Gly Leu Leu Leu Arg Cys Tyr 
        115                 120                 125             


Thr Gln Asn Ile Asp Thr Leu Glu Arg Ile Ala Gly Leu Glu Gln Glu 
    130                 135                 140                 


Asp Leu Val Glu Ala His Gly Thr Phe Tyr Thr Ser His Cys Val Ser 
145                 150                 155                 160 


Ala Ser Cys Arg His Glu Tyr Pro Leu Ser Trp Met Lys Glu Lys Ile 
                165                 170                 175     


Phe Ser Glu Val Thr Pro Lys Cys Glu Asp Cys Gln Ser Leu Val Lys 
            180                 185                 190         


Pro Asp Ile Val Phe Phe Gly Glu Ser Leu Pro Ala Arg Phe Phe Ser 
        195                 200                 205             


Cys Met Gln Ser Asp Phe Leu Lys Val Asp Leu Leu Leu Val Met Gly 
    210                 215                 220                 


Thr Ser Leu Gln Val Gln Pro Phe Ala Ser Leu Ile Ser Lys Ala Pro 
225                 230                 235                 240 


Leu Ser Thr Pro Arg Leu Leu Ile Asn Lys Glu Lys Ala Gly Gln Ser 
                245                 250                 255     


Asp Pro Phe Leu Gly Met Ile Met Gly Leu Gly Gly Gly Met Asp Phe 
            260                 265                 270         


Asp Ser Lys Lys Ala Tyr Arg Asp Val Ala Trp Leu Gly Glu Cys Asp 
        275                 280                 285             


Gln Gly Cys Leu Ala Leu Ala Glu Leu Leu Gly Trp Lys Lys Glu Leu 
    290                 295                 300                 


Glu Asp Leu Val Arg Arg Glu His Ala Ser Ile Asp Ala Gln Ser Gly 
305                 310                 315                 320 


Ala Gly Val Pro Asn Pro Ser Thr Ser Ala Ser Pro Lys Lys Ser Pro 
                325                 330                 335     


Pro Pro Ala Lys Asp Glu Ala Arg Thr Thr Glu Arg Glu Lys Pro Gln 
            340                 345                 350         


<210>  40
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Thr 
            20                  25                  30          


Arg Val Leu Asn Lys Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala 
        35                  40                  45              


Thr Val Met Asp Lys Thr Arg Ala Leu Ile Asp Ser Val Ile Pro Lys 
    50                  55                  60                  


Gly Ala Gln Ala Cys Gln Ile Cys Ile Thr Tyr Ile Cys Glu Glu Asp 
65                  70                  75                  80  


Ser Tyr Leu Ala Gly Thr Leu Gly Leu Ser Ala Asp Gln Thr Ser Gly 
                85                  90                  95      


Asn Tyr Leu Asn Met Gln Asp Ser Gln Gly Val Leu Ser Ser Phe Pro 
            100                 105                 110         


Ala Pro Gln Ala Val Gln Asp Asn Pro Ala Met Pro Thr Ser Ser Gly 
        115                 120                 125             


Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu Glu Ala Gln Arg Ile 
    130                 135                 140                 


Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile Met Asp Lys Ser Ser 
145                 150                 155                 160 


Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Glu Glu Phe Asp Ser Ile 
                165                 170                 175     


Pro Arg Arg Thr Gly Ala Glu Val Asp Ile Thr Gly Met Thr Met Leu 
            180                 185                 190         


Leu Gln Asn Leu Gly Tyr Ser Val Asp Val Lys Lys Asn Leu Thr Ala 
        195                 200                 205             


Ser Asp Met Thr Thr Glu Leu Glu Ala Phe Ala His Arg Pro Glu His 
    210                 215                 220                 


Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser His Gly Ile Arg 
225                 230                 235                 240 


Glu Gly Ile Cys Gly Lys Lys His Ser Glu Gln Val Pro Asp Ile Leu 
                245                 250                 255     


Gln Leu Asn Ala Ile Phe Asn Met Leu Asn Thr Lys Asn Cys Pro Ser 
            260                 265                 270         


Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Asp 
        275                 280                 285             


Ser Pro Gly Val Val Trp Phe Lys Asp Ser Val Gly Val Ser Gly Asn 
    290                 295                 300                 


Leu Ser Leu Pro Thr Thr Glu Glu Phe Glu Asp Asp Ala Ile Lys Lys 
305                 310                 315                 320 


Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro Asp 
                325                 330                 335     


Asn Val Ser Trp Arg His Pro Thr Met Gly Ser Val Phe Ile Gly Arg 
            340                 345                 350         


Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp Val Glu Glu 
        355                 360                 365             


Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp Gly Arg Ala 
    370                 375                 380                 


Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr Arg Cys Phe Tyr Leu 
385                 390                 395                 400 


Phe Pro Gly His 
                


<210>  41
<211>  383
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Gly Thr Ile Asn Gly Leu Leu Asp Glu Leu Leu Gln Thr 
            20                  25                  30          


Arg Val Leu Asn Lys Glu Glu Met Glu Lys Val Lys Arg Glu Asn Ala 
        35                  40                  45              


Thr Val Met Asp Lys Thr Arg Ala Leu Ile Asp Ser Val Ile Pro Lys 
    50                  55                  60                  


Gly Ala Gln Ala Cys Gln Ile Cys Ile Thr Tyr Ile Cys Glu Glu Asp 
65                  70                  75                  80  


Ser Tyr Leu Ala Gly Thr Leu Gly Leu Ser Ala Ala Pro Gln Ala Val 
                85                  90                  95      


Gln Asp Asn Pro Ala Met Pro Thr Ser Ser Gly Ser Glu Gly Asn Val 
            100                 105                 110         


Lys Leu Cys Ser Leu Glu Glu Ala Gln Arg Ile Trp Lys Gln Lys Ser 
        115                 120                 125             


Ala Glu Ile Tyr Pro Ile Met Asp Lys Ser Ser Arg Thr Arg Leu Ala 
    130                 135                 140                 


Leu Ile Ile Cys Asn Glu Glu Phe Asp Ser Ile Pro Arg Arg Thr Gly 
145                 150                 155                 160 


Ala Glu Val Asp Ile Thr Gly Met Thr Met Leu Leu Gln Asn Leu Gly 
                165                 170                 175     


Tyr Ser Val Asp Val Lys Lys Asn Leu Thr Ala Ser Asp Met Thr Thr 
            180                 185                 190         


Glu Leu Glu Ala Phe Ala His Arg Pro Glu His Lys Thr Ser Asp Ser 
        195                 200                 205             


Thr Phe Leu Val Phe Met Ser His Gly Ile Arg Glu Gly Ile Cys Gly 
    210                 215                 220                 


Lys Lys His Ser Glu Gln Val Pro Asp Ile Leu Gln Leu Asn Ala Ile 
225                 230                 235                 240 


Phe Asn Met Leu Asn Thr Lys Asn Cys Pro Ser Leu Lys Asp Lys Pro 
                245                 250                 255     


Lys Val Ile Ile Ile Gln Ala Cys Arg Gly Asp Ser Pro Gly Val Val 
            260                 265                 270         


Trp Phe Lys Asp Ser Val Gly Val Ser Gly Asn Leu Ser Leu Pro Thr 
        275                 280                 285             


Thr Glu Glu Phe Glu Asp Asp Ala Ile Lys Lys Ala His Ile Glu Lys 
    290                 295                 300                 


Asp Phe Ile Ala Phe Cys Ser Ser Thr Pro Asp Asn Val Ser Trp Arg 
305                 310                 315                 320 


His Pro Thr Met Gly Ser Val Phe Ile Gly Arg Leu Ile Glu His Met 
                325                 330                 335     


Gln Glu Tyr Ala Cys Ser Cys Asp Val Glu Glu Ile Phe Arg Lys Val 
            340                 345                 350         


Arg Phe Ser Phe Glu Gln Pro Asp Gly Arg Ala Gln Met Pro Thr Thr 
        355                 360                 365             


Glu Arg Val Thr Leu Thr Arg Cys Phe Tyr Leu Phe Pro Gly His 
    370                 375                 380             


<210>  42
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Ala Pro Gln Ala Val Gln Asp Asn Pro Ala Met Pro Thr 
            20                  25                  30          


Ser Ser Gly Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu Glu Ala 
        35                  40                  45              


Gln Arg Ile Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile Met Asp 
    50                  55                  60                  


Lys Ser Ser Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Glu Glu Phe 
65                  70                  75                  80  


Asp Ser Ile Pro Arg Arg Thr Gly Ala Glu Val Asp Ile Thr Gly Met 
                85                  90                  95      


Thr Met Leu Leu Gln Asn Leu Gly Tyr Ser Val Asp Val Lys Lys Asn 
            100                 105                 110         


Leu Thr Ala Ser Asp Met Thr Thr Glu Leu Glu Ala Phe Ala His Arg 
        115                 120                 125             


Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser His 
    130                 135                 140                 


Gly Ile Arg Glu Gly Ile Cys Gly Lys Lys His Ser Glu Gln Val Pro 
145                 150                 155                 160 


Asp Ile Leu Gln Leu Asn Ala Ile Phe Asn Met Leu Asn Thr Lys Asn 
                165                 170                 175     


Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala Cys 
            180                 185                 190         


Arg Gly Asp Ser Pro Gly Val Val Trp Phe Lys Asp Ser Val Gly Val 
        195                 200                 205             


Ser Gly Asn Leu Ser Leu Pro Thr Thr Glu Glu Phe Glu Asp Asp Ala 
    210                 215                 220                 


Ile Lys Lys Ala His Ile Glu Lys Asp Phe Ile Ala Phe Cys Ser Ser 
225                 230                 235                 240 


Thr Pro Asp Asn Val Ser Trp Arg His Pro Thr Met Gly Ser Val Phe 
                245                 250                 255     


Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp 
            260                 265                 270         


Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp 
        275                 280                 285             


Gly Arg Ala Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr Arg Cys 
    290                 295                 300                 


Phe Tyr Leu Phe Pro Gly His 
305                 310     


<210>  43
<211>  263
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Ala Pro Gln Ala Val Gln Asp Asn Pro Ala Met Pro Thr 
            20                  25                  30          


Ser Ser Gly Ser Glu Gly Asn Val Lys Leu Cys Ser Leu Glu Glu Ala 
        35                  40                  45              


Gln Arg Ile Trp Lys Gln Lys Ser Ala Glu Ile Tyr Pro Ile Met Asp 
    50                  55                  60                  


Lys Ser Ser Arg Thr Arg Leu Ala Leu Ile Ile Cys Asn Glu Glu Phe 
65                  70                  75                  80  


Asp Ser Ile Pro Arg Arg Thr Gly Ala Glu Val Asp Ile Thr Gly Met 
                85                  90                  95      


Thr Met Leu Leu Gln Asn Leu Gly Tyr Ser Val Asp Val Lys Lys Asn 
            100                 105                 110         


Leu Thr Ala Ser Asp Met Thr Thr Glu Leu Glu Ala Phe Ala His Arg 
        115                 120                 125             


Pro Glu His Lys Thr Ser Asp Ser Thr Phe Leu Val Phe Met Ser His 
    130                 135                 140                 


Gly Ile Arg Glu Gly Ile Cys Gly Lys Lys His Ser Glu Gln Val Pro 
145                 150                 155                 160 


Asp Ile Leu Gln Leu Asn Ala Ile Phe Asn Met Leu Asn Thr Lys Asn 
                165                 170                 175     


Cys Pro Ser Leu Lys Asp Lys Pro Lys Val Ile Ile Ile Gln Ala Cys 
            180                 185                 190         


Arg Gly Asp Asn Val Ser Trp Arg His Pro Thr Met Gly Ser Val Phe 
        195                 200                 205             


Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys Asp 
    210                 215                 220                 


Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro Asp 
225                 230                 235                 240 


Gly Arg Ala Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr Arg Cys 
                245                 250                 255     


Phe Tyr Leu Phe Pro Gly His 
            260             


<210>  44
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Asp Lys Val Leu Lys Glu Lys Arg Lys Leu Phe Ile Arg Ser 
1               5                   10                  15      


Met Gly Glu Asp Asn Val Ser Trp Arg His Pro Thr Met Gly Ser Val 
            20                  25                  30          


Phe Ile Gly Arg Leu Ile Glu His Met Gln Glu Tyr Ala Cys Ser Cys 
        35                  40                  45              


Asp Val Glu Glu Ile Phe Arg Lys Val Arg Phe Ser Phe Glu Gln Pro 
    50                  55                  60                  


Asp Gly Arg Ala Gln Met Pro Thr Thr Glu Arg Val Thr Leu Thr Arg 
65                  70                  75                  80  


Cys Phe Tyr Leu Phe Pro Gly His 
                85              


<210>  45
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  45
ccagaataag gcatttctct a                                                 21


<210>  46
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  46
aagcggcttg agggtaatca a                                                 21


<210>  47
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  47
attccacgtc ttgccctcat tattcaagag ataatgaggg caagacgtgt ttttttg          57


<210>  48
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  48
gatccaaaaa aacacgtctt gccctcatta tctcttgaat aatgagggca agacgtgg         58


<210>  49
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  49
attcggacaa taaatggatt gttggtcaag agccaacaat ccatttattg tccg             54


<210>  50
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  50
gatccggaca ataaatggat tgttggctct tgaccaacaa tccatttatt gtccg            55


<210>  51
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  51
attcccacat gactttccag gagtttcaag agaactcctg gaaagtcatg tggttttttg       60


<210>  52
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  52
gatccaaaaa accacatgac tttccaggag ttctcttgaa actcctggaa agtcatgtgg       60

g                                                                       61


<210>  53
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  53
attcgggtga agatatcgac ataattcaag agattatgtc gatatcttca cccttttttg       60


<210>  54
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  54
gatccaaaaa agggtgaaga tatcgacata atctcttgaa ttatgtcgat atcttcaccc       60

g                                                                       61


