                         SEQUENCE LISTING

<110>  The California Institute of Technology
 
<120>  ENGINEERED SYNTHASE FOR PRODUCTION OF TRYPTOPHAN DERIVATIVES AND 
       INTRANSIGENT SUBSTRATES

<130>  00016-132WO1

<140>  Not yet assigned
<141>  2017-08-24

<150>  US 62/379,039
<151>  2016-08-24

<150>  US 62/462,193
<151>  2017-02-22

<150>  US 62/507,383
<151>  2017-05-17

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  1191
<212>  DNA
<213>  Pyrococcus furiosus


<220>
<221>  CDS
<222>  (1)..(1191)

<400>  1
atg tgg ttc ggt gaa ttt ggt ggt cag tac gtg cca gaa acg ctg att         48
Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Ile           
1               5                   10                  15                

gaa ccg ctg aaa gag ctg gaa aaa gct tac aaa cgt ttc aaa gat gac         96
Glu Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp           
            20                  25                  30                    

gaa gaa ttc aat cgt caa ctg aat tac tac ctg aaa acc tgg gca ggt        144
Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly           
        35                  40                  45                        

cgt cca acc cca ctg tac tac gca aaa cgc ctg act gaa aaa atc ggt        192
Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly           
    50                  55                  60                            

ggt gct aaa atc tac ctg aaa cgt gaa gac ctg gtt cac ggt ggt gca        240
Gly Ala Lys Ile Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala           
65                  70                  75                  80            

cac aag acc aac aac gcc atc ggt cag gca ctg ctg gca aag ttc atg        288
His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Phe Met           
                85                  90                  95                

ggt aaa act cgt ctg atc gct gag acc ggt gct ggt cag cac ggc gta        336
Gly Lys Thr Arg Leu Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val           
            100                 105                 110                   

gcg act gca atg gct ggt gca ctg ctg ggc atg aaa gtg gac att tac        384
Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr           
        115                 120                 125                       

atg ggt gct gag gac gta gaa cgt cag aaa atg aac gta ttc cgt atg        432
Met Gly Ala Glu Asp Val Glu Arg Gln Lys Met Asn Val Phe Arg Met           
    130                 135                 140                           

aag ctg ctg ggt gca aac gta att cca gtt aac tcc ggt tct cgc acc        480
Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr           
145                 150                 155                 160           

ctg aaa gac gca atc aac gag gct ctg cgt gat tgg gtg gct act ttt        528
Leu Lys Asp Ala Ile Asn Glu Ala Leu Arg Asp Trp Val Ala Thr Phe           
                165                 170                 175               

gaa tac acc cac tac ctg atc ggt tcc gtg gtc ggt cca cat ccg tat        576
Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr           
            180                 185                 190                   

ccg acc atc gtt cgt gat ttt cag tct gtt atc ggt cgt gag gct aaa        624
Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys           
        195                 200                 205                       

gcg cag atc ctg gag gct gaa ggt cag ctg cca gat gta atc gtt gct        672
Ala Gln Ile Leu Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala           
    210                 215                 220                           

tgt gtt ggt ggt ggc tct aac gcg atg ggt atc ttt tac ccg ttc gtg        720
Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val           
225                 230                 235                 240           

aac gac aaa aaa gtt aag ctg gtt ggc gtt gag gct ggt ggt aaa ggc        768
Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly           
                245                 250                 255               

ctg gaa tct ggt aag cat tcc gct agc ctg aac gca ggt cag gtt ggt        816
Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly           
            260                 265                 270                   

gtg ttc cat ggc atg ctg tcc tac ttt ctg cag gac gaa gaa ggt cag        864
Val Phe His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln           
        275                 280                 285                       

atc aaa cca act cac tcc atc gca cca ggt ctg gat tat cca ggt gtt        912
Ile Lys Pro Thr His Ser Ile Ala Pro Gly Leu Asp Tyr Pro Gly Val           
    290                 295                 300                           

ggt cca gaa cac gct tac ctg aaa aaa att cag cgt gct gaa tac gtg        960
Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val           
305                 310                 315                 320           

act gta acc gat gaa gaa gca ctg aaa gcg ttc cat gaa ctg agc cgt       1008
Thr Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg           
                325                 330                 335               

acc gaa ggt atc atc cca gct ctg gaa tct gcg cat gct gtg gct tac       1056
Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr           
            340                 345                 350                   

gct atg aaa ctg gct aag gaa atg tct cgt gat gag atc atc atc gta       1104
Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val           
        355                 360                 365                       

aac ctg tct ggt cgt ggt gac aaa gac ctg gat att gtt ctg aaa gtg       1152
Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Val           
    370                 375                 380                           

tct ggc aac gtg ctc gag cac cat cac cat cac cat tga                   1191
Ser Gly Asn Val Leu Glu His His His His His His                           
385                 390                 395                               


<210>  2
<211>  396
<212>  PRT
<213>  Pyrococcus furiosus

<400>  2

Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Ile 
1               5                   10                  15      


Glu Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp 
            20                  25                  30          


Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly 
        35                  40                  45              


Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly 
    50                  55                  60                  


Gly Ala Lys Ile Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala 
65                  70                  75                  80  


His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Phe Met 
                85                  90                  95      


Gly Lys Thr Arg Leu Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val 
            100                 105                 110         


Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr 
        115                 120                 125             


Met Gly Ala Glu Asp Val Glu Arg Gln Lys Met Asn Val Phe Arg Met 
    130                 135                 140                 


Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr 
145                 150                 155                 160 


Leu Lys Asp Ala Ile Asn Glu Ala Leu Arg Asp Trp Val Ala Thr Phe 
                165                 170                 175     


Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr 
            180                 185                 190         


Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys 
        195                 200                 205             


Ala Gln Ile Leu Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala 
    210                 215                 220                 


Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val 
225                 230                 235                 240 


Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly 
                245                 250                 255     


Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly 
            260                 265                 270         


Val Phe His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln 
        275                 280                 285             


Ile Lys Pro Thr His Ser Ile Ala Pro Gly Leu Asp Tyr Pro Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val 
305                 310                 315                 320 


Thr Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg 
                325                 330                 335     


Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr 
            340                 345                 350         


Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val 
        355                 360                 365             


Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Val 
    370                 375                 380                 


Ser Gly Asn Val Leu Glu His His His His His His 
385                 390                 395     


<210>  3
<211>  1218
<212>  DNA
<213>  Archaeoglobus fulgidus


<220>
<221>  CDS
<222>  (1)..(1218)

<400>  3
atg cgt tgc tgg ctg gaa aac ctg tct ggc ggt cgt aaa atg aag ttt         48
Met Arg Cys Trp Leu Glu Asn Leu Ser Gly Gly Arg Lys Met Lys Phe           
1               5                   10                  15                

ggt gag ttt ggc ggt cgt ttc gtt ccg gag gta ctg atc cca ccg ctg         96
Gly Glu Phe Gly Gly Arg Phe Val Pro Glu Val Leu Ile Pro Pro Leu           
            20                  25                  30                    

gaa gaa ctg gaa aaa gca tat gac cgc ttt aaa gat gat gag gaa ttt        144
Glu Glu Leu Glu Lys Ala Tyr Asp Arg Phe Lys Asp Asp Glu Glu Phe           
        35                  40                  45                        

aaa gca cgt ctg gaa tac tac ctg aaa tcc tat gca ggt cgt ccg acc        192
Lys Ala Arg Leu Glu Tyr Tyr Leu Lys Ser Tyr Ala Gly Arg Pro Thr           
    50                  55                  60                            

cca ctg tac ttc gct gag aac ctg agc cgt gaa ctg ggc gtc aaa atc        240
Pro Leu Tyr Phe Ala Glu Asn Leu Ser Arg Glu Leu Gly Val Lys Ile           
65                  70                  75                  80            

tat ctg aaa cgc gaa gac ctg ctg cat ggt ggt gcg cac aaa atc aac        288
Tyr Leu Lys Arg Glu Asp Leu Leu His Gly Gly Ala His Lys Ile Asn           
                85                  90                  95                

aat acc atc ggt caa gcg ctg ctg gcg aaa ttc atg ggt aaa aag cgt        336
Asn Thr Ile Gly Gln Ala Leu Leu Ala Lys Phe Met Gly Lys Lys Arg           
            100                 105                 110                   

gtt att gcg gaa acc ggt gca ggt cag cac ggt gtg gcg act gcg atg        384
Val Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val Ala Thr Ala Met           
        115                 120                 125                       

gct gcg gca ctg ctg ggc ctg gaa gcg gaa att tat atg ggt gct gaa        432
Ala Ala Ala Leu Leu Gly Leu Glu Ala Glu Ile Tyr Met Gly Ala Glu           
    130                 135                 140                           

gac tat gag cgc caa aaa atg aac gtg ttt cgt atg gaa ctg ctg ggt        480
Asp Tyr Glu Arg Gln Lys Met Asn Val Phe Arg Met Glu Leu Leu Gly           
145                 150                 155                 160           

gcc aaa gtc acc gct gta gaa agc ggt tcc cgt acc ctg aaa gac gca        528
Ala Lys Val Thr Ala Val Glu Ser Gly Ser Arg Thr Leu Lys Asp Ala           
                165                 170                 175               

atc aac gag gca ctg cgt gac tgg gtg gaa tct ttc gaa cac act cac        576
Ile Asn Glu Ala Leu Arg Asp Trp Val Glu Ser Phe Glu His Thr His           
            180                 185                 190                   

tac ctg atc ggt tct gta gta ggt ccg cat ccg ttc ccg act atc gtc        624
Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Phe Pro Thr Ile Val           
        195                 200                 205                       

cgc gac ttc caa gct gtg atc ggc aag gag gca cgc cgt cag atc atc        672
Arg Asp Phe Gln Ala Val Ile Gly Lys Glu Ala Arg Arg Gln Ile Ile           
    210                 215                 220                           

gaa gcg gaa ggt ggt atg ccg gat gct atc atc gcg tgc gta ggc ggt        720
Glu Ala Glu Gly Gly Met Pro Asp Ala Ile Ile Ala Cys Val Gly Gly           
225                 230                 235                 240           

ggc tcc aac gct atg ggc atc ttc cac ccg ttc ctg aac gac gac gta        768
Gly Ser Asn Ala Met Gly Ile Phe His Pro Phe Leu Asn Asp Asp Val           
                245                 250                 255               

cgt ctg att ggt gta gaa gct ggc ggt gaa ggt atc gaa tct ggt cgt        816
Arg Leu Ile Gly Val Glu Ala Gly Gly Glu Gly Ile Glu Ser Gly Arg           
            260                 265                 270                   

cat tcc gca agc ctg acc gct ggc tct aaa ggt gtt ctg cac ggt atg        864
His Ser Ala Ser Leu Thr Ala Gly Ser Lys Gly Val Leu His Gly Met           
        275                 280                 285                       

ctg agc tat ttc ctg cag gac gaa gag ggt atg atg ctg gac acc cac        912
Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Met Met Leu Asp Thr His           
    290                 295                 300                           

tcc gta tct gca ggt ctg gat tat ccg ggt gtt ggt ccg gaa cac gcc        960
Ser Val Ser Ala Gly Leu Asp Tyr Pro Gly Val Gly Pro Glu His Ala           
305                 310                 315                 320           

tac ctg aag gaa acg ggt cgt tgt gag tac gtt acc gta aat gac gaa       1008
Tyr Leu Lys Glu Thr Gly Arg Cys Glu Tyr Val Thr Val Asn Asp Glu           
                325                 330                 335               

gaa gcg ctg cgt gct ttc aaa acc ctg tcc aaa ctg gaa ggt atc att       1056
Glu Ala Leu Arg Ala Phe Lys Thr Leu Ser Lys Leu Glu Gly Ile Ile           
            340                 345                 350                   

cct gcg ctg gaa tcc gct cac gcc att gca tat gct atg aaa atg gcc       1104
Pro Ala Leu Glu Ser Ala His Ala Ile Ala Tyr Ala Met Lys Met Ala           
        355                 360                 365                       

gag gaa atg cag cgt gat gat gtg ctg gtt gta aac ctg tcc ggt cgt       1152
Glu Glu Met Gln Arg Asp Asp Val Leu Val Val Asn Leu Ser Gly Arg           
    370                 375                 380                           

ggc gat aaa gat atg gac atc gta cgt cgt cgt ctg gct ctc gag cac       1200
Gly Asp Lys Asp Met Asp Ile Val Arg Arg Arg Leu Ala Leu Glu His           
385                 390                 395                 400           

cac cac cac cac cac tga                                               1218
His His His His His                                                       
                405                                                       


<210>  4
<211>  405
<212>  PRT
<213>  Archaeoglobus fulgidus

<400>  4

Met Arg Cys Trp Leu Glu Asn Leu Ser Gly Gly Arg Lys Met Lys Phe 
1               5                   10                  15      


Gly Glu Phe Gly Gly Arg Phe Val Pro Glu Val Leu Ile Pro Pro Leu 
            20                  25                  30          


Glu Glu Leu Glu Lys Ala Tyr Asp Arg Phe Lys Asp Asp Glu Glu Phe 
        35                  40                  45              


Lys Ala Arg Leu Glu Tyr Tyr Leu Lys Ser Tyr Ala Gly Arg Pro Thr 
    50                  55                  60                  


Pro Leu Tyr Phe Ala Glu Asn Leu Ser Arg Glu Leu Gly Val Lys Ile 
65                  70                  75                  80  


Tyr Leu Lys Arg Glu Asp Leu Leu His Gly Gly Ala His Lys Ile Asn 
                85                  90                  95      


Asn Thr Ile Gly Gln Ala Leu Leu Ala Lys Phe Met Gly Lys Lys Arg 
            100                 105                 110         


Val Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val Ala Thr Ala Met 
        115                 120                 125             


Ala Ala Ala Leu Leu Gly Leu Glu Ala Glu Ile Tyr Met Gly Ala Glu 
    130                 135                 140                 


Asp Tyr Glu Arg Gln Lys Met Asn Val Phe Arg Met Glu Leu Leu Gly 
145                 150                 155                 160 


Ala Lys Val Thr Ala Val Glu Ser Gly Ser Arg Thr Leu Lys Asp Ala 
                165                 170                 175     


Ile Asn Glu Ala Leu Arg Asp Trp Val Glu Ser Phe Glu His Thr His 
            180                 185                 190         


Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Phe Pro Thr Ile Val 
        195                 200                 205             


Arg Asp Phe Gln Ala Val Ile Gly Lys Glu Ala Arg Arg Gln Ile Ile 
    210                 215                 220                 


Glu Ala Glu Gly Gly Met Pro Asp Ala Ile Ile Ala Cys Val Gly Gly 
225                 230                 235                 240 


Gly Ser Asn Ala Met Gly Ile Phe His Pro Phe Leu Asn Asp Asp Val 
                245                 250                 255     


Arg Leu Ile Gly Val Glu Ala Gly Gly Glu Gly Ile Glu Ser Gly Arg 
            260                 265                 270         


His Ser Ala Ser Leu Thr Ala Gly Ser Lys Gly Val Leu His Gly Met 
        275                 280                 285             


Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Met Met Leu Asp Thr His 
    290                 295                 300                 


Ser Val Ser Ala Gly Leu Asp Tyr Pro Gly Val Gly Pro Glu His Ala 
305                 310                 315                 320 


Tyr Leu Lys Glu Thr Gly Arg Cys Glu Tyr Val Thr Val Asn Asp Glu 
                325                 330                 335     


Glu Ala Leu Arg Ala Phe Lys Thr Leu Ser Lys Leu Glu Gly Ile Ile 
            340                 345                 350         


Pro Ala Leu Glu Ser Ala His Ala Ile Ala Tyr Ala Met Lys Met Ala 
        355                 360                 365             


Glu Glu Met Gln Arg Asp Asp Val Leu Val Val Asn Leu Ser Gly Arg 
    370                 375                 380                 


Gly Asp Lys Asp Met Asp Ile Val Arg Arg Arg Leu Ala Leu Glu His 
385                 390                 395                 400 


His His His His His 
                405 


<210>  5
<211>  1194
<212>  DNA
<213>  Thermotoga maritima


<220>
<221>  CDS
<222>  (1)..(1194)

<400>  5
atg aaa ggc tac ttc ggt ccg tac ggt ggc cag tac gtg ccg gaa atc         48
Met Lys Gly Tyr Phe Gly Pro Tyr Gly Gly Gln Tyr Val Pro Glu Ile           
1               5                   10                  15                

ctg atg cca gct ctg gaa gaa ctg gaa gct gcg tac gaa gaa atc atg         96
Leu Met Pro Ala Leu Glu Glu Leu Glu Ala Ala Tyr Glu Glu Ile Met           
            20                  25                  30                    

aaa gat gag tct ttc tgg aaa gaa ttc aat gac ctg ctg cgc gat tat        144
Lys Asp Glu Ser Phe Trp Lys Glu Phe Asn Asp Leu Leu Arg Asp Tyr           
        35                  40                  45                        

gcg ggt cgt ccg act ccg ctg tac ttc gca cgt cgt ctg tcc gaa aaa        192
Ala Gly Arg Pro Thr Pro Leu Tyr Phe Ala Arg Arg Leu Ser Glu Lys           
    50                  55                  60                            

tac ggt gct cgc atc tat ctg aaa cgt gaa gac ctg ctg cat act ggt        240
Tyr Gly Ala Arg Ile Tyr Leu Lys Arg Glu Asp Leu Leu His Thr Gly           
65                  70                  75                  80            

gcg cat aaa atc aat aac gct atc ggc cag gtt ctg ctg gca aaa aaa        288
Ala His Lys Ile Asn Asn Ala Ile Gly Gln Val Leu Leu Ala Lys Lys           
                85                  90                  95                

atg ggc aaa acc cgt atc att gct gaa acg ggt gct ggt cag cac ggc        336
Met Gly Lys Thr Arg Ile Ile Ala Glu Thr Gly Ala Gly Gln His Gly           
            100                 105                 110                   

gta gca act gct acc gca gca gcg ctg ttc ggt atg gaa tgt gta atc        384
Val Ala Thr Ala Thr Ala Ala Ala Leu Phe Gly Met Glu Cys Val Ile           
        115                 120                 125                       

tat atg ggc gaa gaa gac acg atc cgc cag aaa ccg aac gtt gaa cgt        432
Tyr Met Gly Glu Glu Asp Thr Ile Arg Gln Lys Pro Asn Val Glu Arg           
    130                 135                 140                           

atg aaa ctg ctg ggt gct aaa gtt gta ccg gta aaa tcc ggt agc cgt        480
Met Lys Leu Leu Gly Ala Lys Val Val Pro Val Lys Ser Gly Ser Arg           
145                 150                 155                 160           

acc ctg aaa gac gca att aac gaa gct ctg cgt gac tgg att acc aac        528
Thr Leu Lys Asp Ala Ile Asn Glu Ala Leu Arg Asp Trp Ile Thr Asn           
                165                 170                 175               

ctg cag acc acc tat tac gtg atc ggc tct gtg gtt ggt ccg cat cca        576
Leu Gln Thr Thr Tyr Tyr Val Ile Gly Ser Val Val Gly Pro His Pro           
            180                 185                 190                   

tat ccg att atc gta cgt aac ttc caa aag gtt atc ggc gaa gag acc        624
Tyr Pro Ile Ile Val Arg Asn Phe Gln Lys Val Ile Gly Glu Glu Thr           
        195                 200                 205                       

aaa aaa cag att ctg gaa aaa gaa ggc cgt ctg ccg gac tac atc gtt        672
Lys Lys Gln Ile Leu Glu Lys Glu Gly Arg Leu Pro Asp Tyr Ile Val           
    210                 215                 220                           

gcg tgc gtg ggt ggt ggt tct aac gct gcc ggt atc ttc tat ccg ttt        720
Ala Cys Val Gly Gly Gly Ser Asn Ala Ala Gly Ile Phe Tyr Pro Phe           
225                 230                 235                 240           

atc gat tct ggt gtg aag ctg atc ggc gta gaa gcc ggt ggc gaa ggt        768
Ile Asp Ser Gly Val Lys Leu Ile Gly Val Glu Ala Gly Gly Glu Gly           
                245                 250                 255               

ctg gaa acc ggt aaa cat gcg gct tct ctg ctg aaa ggt aaa atc ggc        816
Leu Glu Thr Gly Lys His Ala Ala Ser Leu Leu Lys Gly Lys Ile Gly           
            260                 265                 270                   

tac ctg cac ggt tct aag acg ttc gtt ctg cag gat gac tgg ggt caa        864
Tyr Leu His Gly Ser Lys Thr Phe Val Leu Gln Asp Asp Trp Gly Gln           
        275                 280                 285                       

gtt cag gtg acg cac tcc gtc tcc gct ggc ctg gac tac tcc ggt gtc        912
Val Gln Val Thr His Ser Val Ser Ala Gly Leu Asp Tyr Ser Gly Val           
    290                 295                 300                           

ggt ccg gaa cac gcc tat tgg cgt gag acc ggt aaa gtg ctg tac gat        960
Gly Pro Glu His Ala Tyr Trp Arg Glu Thr Gly Lys Val Leu Tyr Asp           
305                 310                 315                 320           

gct gtg acc gat gaa gaa gct ctg gac gca ttc atc gaa ctg tct cgc       1008
Ala Val Thr Asp Glu Glu Ala Leu Asp Ala Phe Ile Glu Leu Ser Arg           
                325                 330                 335               

ctg gaa ggc atc atc cca gcc ctg gag tct tct cac gca ctg gct tat       1056
Leu Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser His Ala Leu Ala Tyr           
            340                 345                 350                   

ctg aag aag atc aac atc aag ggt aaa gtt gtg gtg gtt aat ctg tct       1104
Leu Lys Lys Ile Asn Ile Lys Gly Lys Val Val Val Val Asn Leu Ser           
        355                 360                 365                       

ggt cgt ggt gac aag gat ctg gaa tct gta ctg aac cac ccg tat gtt       1152
Gly Arg Gly Asp Lys Asp Leu Glu Ser Val Leu Asn His Pro Tyr Val           
    370                 375                 380                           

cgc gaa cgc atc cgc ctc gag cac cac cac cac cac cac tga               1194
Arg Glu Arg Ile Arg Leu Glu His His His His His His                       
385                 390                 395                               


<210>  6
<211>  397
<212>  PRT
<213>  Thermotoga maritima

<400>  6

Met Lys Gly Tyr Phe Gly Pro Tyr Gly Gly Gln Tyr Val Pro Glu Ile 
1               5                   10                  15      


Leu Met Pro Ala Leu Glu Glu Leu Glu Ala Ala Tyr Glu Glu Ile Met 
            20                  25                  30          


Lys Asp Glu Ser Phe Trp Lys Glu Phe Asn Asp Leu Leu Arg Asp Tyr 
        35                  40                  45              


Ala Gly Arg Pro Thr Pro Leu Tyr Phe Ala Arg Arg Leu Ser Glu Lys 
    50                  55                  60                  


Tyr Gly Ala Arg Ile Tyr Leu Lys Arg Glu Asp Leu Leu His Thr Gly 
65                  70                  75                  80  


Ala His Lys Ile Asn Asn Ala Ile Gly Gln Val Leu Leu Ala Lys Lys 
                85                  90                  95      


Met Gly Lys Thr Arg Ile Ile Ala Glu Thr Gly Ala Gly Gln His Gly 
            100                 105                 110         


Val Ala Thr Ala Thr Ala Ala Ala Leu Phe Gly Met Glu Cys Val Ile 
        115                 120                 125             


Tyr Met Gly Glu Glu Asp Thr Ile Arg Gln Lys Pro Asn Val Glu Arg 
    130                 135                 140                 


Met Lys Leu Leu Gly Ala Lys Val Val Pro Val Lys Ser Gly Ser Arg 
145                 150                 155                 160 


Thr Leu Lys Asp Ala Ile Asn Glu Ala Leu Arg Asp Trp Ile Thr Asn 
                165                 170                 175     


Leu Gln Thr Thr Tyr Tyr Val Ile Gly Ser Val Val Gly Pro His Pro 
            180                 185                 190         


Tyr Pro Ile Ile Val Arg Asn Phe Gln Lys Val Ile Gly Glu Glu Thr 
        195                 200                 205             


Lys Lys Gln Ile Leu Glu Lys Glu Gly Arg Leu Pro Asp Tyr Ile Val 
    210                 215                 220                 


Ala Cys Val Gly Gly Gly Ser Asn Ala Ala Gly Ile Phe Tyr Pro Phe 
225                 230                 235                 240 


Ile Asp Ser Gly Val Lys Leu Ile Gly Val Glu Ala Gly Gly Glu Gly 
                245                 250                 255     


Leu Glu Thr Gly Lys His Ala Ala Ser Leu Leu Lys Gly Lys Ile Gly 
            260                 265                 270         


Tyr Leu His Gly Ser Lys Thr Phe Val Leu Gln Asp Asp Trp Gly Gln 
        275                 280                 285             


Val Gln Val Thr His Ser Val Ser Ala Gly Leu Asp Tyr Ser Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Trp Arg Glu Thr Gly Lys Val Leu Tyr Asp 
305                 310                 315                 320 


Ala Val Thr Asp Glu Glu Ala Leu Asp Ala Phe Ile Glu Leu Ser Arg 
                325                 330                 335     


Leu Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser His Ala Leu Ala Tyr 
            340                 345                 350         


Leu Lys Lys Ile Asn Ile Lys Gly Lys Val Val Val Val Asn Leu Ser 
        355                 360                 365             


Gly Arg Gly Asp Lys Asp Leu Glu Ser Val Leu Asn His Pro Tyr Val 
    370                 375                 380                 


Arg Glu Arg Ile Arg Leu Glu His His His His His His 
385                 390                 395         


<210>  7
<211>  1218
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(1218)

<400>  7
atg act act ctg ctg aac ccg tac ttc ggt gag ttc ggt ggt atg tac         48
Met Thr Thr Leu Leu Asn Pro Tyr Phe Gly Glu Phe Gly Gly Met Tyr           
1               5                   10                  15                

gtg cca cag atc ctg atg cct gcg ctg cgc cag ctg gag gag gcg ttt         96
Val Pro Gln Ile Leu Met Pro Ala Leu Arg Gln Leu Glu Glu Ala Phe           
            20                  25                  30                    

gtt agc gcc cag aaa gat ccg gag ttc cag gct cag ttc aac gac ctg        144
Val Ser Ala Gln Lys Asp Pro Glu Phe Gln Ala Gln Phe Asn Asp Leu           
        35                  40                  45                        

ctg aaa aac tat gct ggt cgt ccg acc gcg ctg acg aaa tgc cag aac        192
Leu Lys Asn Tyr Ala Gly Arg Pro Thr Ala Leu Thr Lys Cys Gln Asn           
    50                  55                  60                            

atc act gct ggt acg aac acc acc ctg tac ctg aag cgt gag gac ctg        240
Ile Thr Ala Gly Thr Asn Thr Thr Leu Tyr Leu Lys Arg Glu Asp Leu           
65                  70                  75                  80            

ctg cat ggt ggt gcg cac aaa acc aac cag gtc ctg ggt caa gca ctg        288
Leu His Gly Gly Ala His Lys Thr Asn Gln Val Leu Gly Gln Ala Leu           
                85                  90                  95                

ctg gca aaa cgt atg ggc aaa act gaa att att gcg gaa acg ggt gca        336
Leu Ala Lys Arg Met Gly Lys Thr Glu Ile Ile Ala Glu Thr Gly Ala           
            100                 105                 110                   

ggt cag cac ggt gta gct tct gcg ctg gcc agc gca ctg ctg ggt ctg        384
Gly Gln His Gly Val Ala Ser Ala Leu Ala Ser Ala Leu Leu Gly Leu           
        115                 120                 125                       

aag tgt cgt atc tat atg ggt gcg aaa gat gtg gag cgt cag tct ccg        432
Lys Cys Arg Ile Tyr Met Gly Ala Lys Asp Val Glu Arg Gln Ser Pro           
    130                 135                 140                           

aac gta ttc cgc atg cgt ctg atg ggt gca gaa gtg atc ccg gta cac        480
Asn Val Phe Arg Met Arg Leu Met Gly Ala Glu Val Ile Pro Val His           
145                 150                 155                 160           

tct ggt tcc gca act ctg aaa gac gca tgt aat gaa gca ctg cgt gac        528
Ser Gly Ser Ala Thr Leu Lys Asp Ala Cys Asn Glu Ala Leu Arg Asp           
                165                 170                 175               

tgg tcc ggt tct tat gaa act gct cac tac atg ctg ggc acc gca gct        576
Trp Ser Gly Ser Tyr Glu Thr Ala His Tyr Met Leu Gly Thr Ala Ala           
            180                 185                 190                   

ggt cct cac ccg tac ccg acc atc gta cgt gaa ttc cag cgc atg att        624
Gly Pro His Pro Tyr Pro Thr Ile Val Arg Glu Phe Gln Arg Met Ile           
        195                 200                 205                       

ggt gaa gaa acc aaa gcg cag atc ctg gaa cgt gaa ggt cgc ctg cca        672
Gly Glu Glu Thr Lys Ala Gln Ile Leu Glu Arg Glu Gly Arg Leu Pro           
    210                 215                 220                           

gat gcg gtg atc gcg tgc gta ggt ggt ggt tcc aac gcg atc ggt atg        720
Asp Ala Val Ile Ala Cys Val Gly Gly Gly Ser Asn Ala Ile Gly Met           
225                 230                 235                 240           

ttc gct gat ttc atc aac gaa acc aac gtt ggc ctg att ggt gta gaa        768
Phe Ala Asp Phe Ile Asn Glu Thr Asn Val Gly Leu Ile Gly Val Glu           
                245                 250                 255               

cca ggt ggc cac ggc att gaa act ggc gag cac ggt gca cct ctg aaa        816
Pro Gly Gly His Gly Ile Glu Thr Gly Glu His Gly Ala Pro Leu Lys           
            260                 265                 270                   

cac ggt cgc gta ggc att tac ttc ggt atg aaa gct ccg atg atg cag        864
His Gly Arg Val Gly Ile Tyr Phe Gly Met Lys Ala Pro Met Met Gln           
        275                 280                 285                       

act gaa gac ggt cag atc gaa gaa tct tac tcc att tct gca ggt ctg        912
Thr Glu Asp Gly Gln Ile Glu Glu Ser Tyr Ser Ile Ser Ala Gly Leu           
    290                 295                 300                           

gac ttc ccg tct gtt ggt ccg caa cac gca tat ctg aac tct acc ggt        960
Asp Phe Pro Ser Val Gly Pro Gln His Ala Tyr Leu Asn Ser Thr Gly           
305                 310                 315                 320           

cgt gcg gac tac gtg tct atc act gac gac gag gct ctg gag gcc ttt       1008
Arg Ala Asp Tyr Val Ser Ile Thr Asp Asp Glu Ala Leu Glu Ala Phe           
                325                 330                 335               

aaa act ctg tgc ctg cac gaa ggt atc att cca gct ctg gaa tcc agc       1056
Lys Thr Leu Cys Leu His Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser           
            340                 345                 350                   

cac gca ctg gca cac gca ctg aaa atg atg cgt gaa aac cca gac aaa       1104
His Ala Leu Ala His Ala Leu Lys Met Met Arg Glu Asn Pro Asp Lys           
        355                 360                 365                       

gaa cag ctg ctg gtg gtt aac ctg agc ggt cgt ggt gac aag gat atc       1152
Glu Gln Leu Leu Val Val Asn Leu Ser Gly Arg Gly Asp Lys Asp Ile           
    370                 375                 380                           

ttc acg gtt cac gac atc ctg aag gct cgt ggt gaa atc ctc gag cac       1200
Phe Thr Val His Asp Ile Leu Lys Ala Arg Gly Glu Ile Leu Glu His           
385                 390                 395                 400           

cac cac cac cac cac tga                                               1218
His His His His His                                                       
                405                                                       


<210>  8
<211>  405
<212>  PRT
<213>  Escherichia coli

<400>  8

Met Thr Thr Leu Leu Asn Pro Tyr Phe Gly Glu Phe Gly Gly Met Tyr 
1               5                   10                  15      


Val Pro Gln Ile Leu Met Pro Ala Leu Arg Gln Leu Glu Glu Ala Phe 
            20                  25                  30          


Val Ser Ala Gln Lys Asp Pro Glu Phe Gln Ala Gln Phe Asn Asp Leu 
        35                  40                  45              


Leu Lys Asn Tyr Ala Gly Arg Pro Thr Ala Leu Thr Lys Cys Gln Asn 
    50                  55                  60                  


Ile Thr Ala Gly Thr Asn Thr Thr Leu Tyr Leu Lys Arg Glu Asp Leu 
65                  70                  75                  80  


Leu His Gly Gly Ala His Lys Thr Asn Gln Val Leu Gly Gln Ala Leu 
                85                  90                  95      


Leu Ala Lys Arg Met Gly Lys Thr Glu Ile Ile Ala Glu Thr Gly Ala 
            100                 105                 110         


Gly Gln His Gly Val Ala Ser Ala Leu Ala Ser Ala Leu Leu Gly Leu 
        115                 120                 125             


Lys Cys Arg Ile Tyr Met Gly Ala Lys Asp Val Glu Arg Gln Ser Pro 
    130                 135                 140                 


Asn Val Phe Arg Met Arg Leu Met Gly Ala Glu Val Ile Pro Val His 
145                 150                 155                 160 


Ser Gly Ser Ala Thr Leu Lys Asp Ala Cys Asn Glu Ala Leu Arg Asp 
                165                 170                 175     


Trp Ser Gly Ser Tyr Glu Thr Ala His Tyr Met Leu Gly Thr Ala Ala 
            180                 185                 190         


Gly Pro His Pro Tyr Pro Thr Ile Val Arg Glu Phe Gln Arg Met Ile 
        195                 200                 205             


Gly Glu Glu Thr Lys Ala Gln Ile Leu Glu Arg Glu Gly Arg Leu Pro 
    210                 215                 220                 


Asp Ala Val Ile Ala Cys Val Gly Gly Gly Ser Asn Ala Ile Gly Met 
225                 230                 235                 240 


Phe Ala Asp Phe Ile Asn Glu Thr Asn Val Gly Leu Ile Gly Val Glu 
                245                 250                 255     


Pro Gly Gly His Gly Ile Glu Thr Gly Glu His Gly Ala Pro Leu Lys 
            260                 265                 270         


His Gly Arg Val Gly Ile Tyr Phe Gly Met Lys Ala Pro Met Met Gln 
        275                 280                 285             


Thr Glu Asp Gly Gln Ile Glu Glu Ser Tyr Ser Ile Ser Ala Gly Leu 
    290                 295                 300                 


Asp Phe Pro Ser Val Gly Pro Gln His Ala Tyr Leu Asn Ser Thr Gly 
305                 310                 315                 320 


Arg Ala Asp Tyr Val Ser Ile Thr Asp Asp Glu Ala Leu Glu Ala Phe 
                325                 330                 335     


Lys Thr Leu Cys Leu His Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser 
            340                 345                 350         


His Ala Leu Ala His Ala Leu Lys Met Met Arg Glu Asn Pro Asp Lys 
        355                 360                 365             


Glu Gln Leu Leu Val Val Asn Leu Ser Gly Arg Gly Asp Lys Asp Ile 
    370                 375                 380                 


Phe Thr Val His Asp Ile Leu Lys Ala Arg Gly Glu Ile Leu Glu His 
385                 390                 395                 400 


His His His His His 
                405 


<210>  9
<211>  1191
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PfTrpB2B9


<220>
<221>  CDS
<222>  (1)..(1191)

<400>  9
atg tgg ttc ggt gaa ttt ggt ggt cag tac gtg cca gaa acg ctg gtt         48
Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val           
1               5                   10                  15                

gga ccc ctg aaa gag ctg gaa aaa gct tac aaa cgt ttc aaa gat gac         96
Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp           
            20                  25                  30                    

gaa gaa ttc aat cgt cag ctg aat tac tac ctg aaa acc tgg gca ggt        144
Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly           
        35                  40                  45                        

cgt cca acc cca ctg tac tac gca aaa cgc ctg act gaa aaa atc ggt        192
Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly           
    50                  55                  60                            

ggt gct aaa gtc tac ctg aaa cgt gaa gac ctg gtt cac ggt ggt gca        240
Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala           
65                  70                  75                  80            

cac aag acc aac aac gcc atc ggt cag gca ctg ctg gca aag ctc atg        288
His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met           
                85                  90                  95                

ggt aaa act cgt ctg atc gct gag acc ggt gct ggt cag cac ggc gta        336
Gly Lys Thr Arg Leu Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val           
            100                 105                 110                   

gcg act gca atg gct ggt gca ctg ctg ggc atg aaa gtg gac att tac        384
Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr           
        115                 120                 125                       

atg ggt gct gag gac gta gaa cgt cag aaa atg aac gta ttc cgt atg        432
Met Gly Ala Glu Asp Val Glu Arg Gln Lys Met Asn Val Phe Arg Met           
    130                 135                 140                           

aag ctg ctg ggt gca aac gta att cca gtt aac tcc ggt tct cgc acc        480
Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr           
145                 150                 155                 160           

ctg aaa gac gca atc aac gag gct ctg cgt gat tgg gtg gct act ttt        528
Leu Lys Asp Ala Ile Asn Glu Ala Leu Arg Asp Trp Val Ala Thr Phe           
                165                 170                 175               

gaa tac acc cac tac cta atc ggt tcc gtg gtc ggt cca cat ccg tat        576
Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr           
            180                 185                 190                   

ccg acc atc gtt cgt gat ttt cag tct gtt atc ggt cgt gag gct aaa        624
Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys           
        195                 200                 205                       

gcg cag atc ctg gag gct gaa ggt cag ctg cca gat gta atc gtt gct        672
Ala Gln Ile Leu Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala           
    210                 215                 220                           

tgt gtt ggt ggt ggc tct aac gcg atg ggt atc ttt tac ccg ttc gtg        720
Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val           
225                 230                 235                 240           

aac gac aaa aaa gtt aag ctg gtt ggc gtt gag gct ggt ggt aaa ggc        768
Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly           
                245                 250                 255               

ctg gaa tct ggt aag cat tcc gct agc ctg aac gca ggt cag gtt ggt        816
Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly           
            260                 265                 270                   

gtg tcc cat ggc atg ctg tcc tac ttt ctg cag gac gaa gaa ggt cag        864
Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln           
        275                 280                 285                       

atc aaa cca agc cac tcc atc gca cca ggt ctg gat tat cca ggt gtt        912
Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp Tyr Pro Gly Val           
    290                 295                 300                           

ggt cca gaa cac gct tac ctg aaa aaa att cag cgt gct gaa tac gtg        960
Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val           
305                 310                 315                 320           

gct gta acc gat gaa gaa gca ctg aaa gcg ttc cat gaa ctg agc cgt       1008
Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg           
                325                 330                 335               

acc gaa ggt atc atc cca gct ctg gaa tct gcg cat gct gtg gct tac       1056
Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr           
            340                 345                 350                   

gct atg aaa ctg gct aag gaa atg tct cgt gat gag atc atc atc gta       1104
Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val           
        355                 360                 365                       

aac ctg tct ggt cgt ggt gac aaa gac ctg gat att gtc ctg aaa gcg       1152
Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala           
    370                 375                 380                           

tct ggc aac gtg ctc gag cac cac cac cac cac cac tga                   1191
Ser Gly Asn Val Leu Glu His His His His His His                           
385                 390                 395                               


<210>  10
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val 
1               5                   10                  15      


Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp 
            20                  25                  30          


Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly 
        35                  40                  45              


Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly 
    50                  55                  60                  


Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala 
65                  70                  75                  80  


His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met 
                85                  90                  95      


Gly Lys Thr Arg Leu Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val 
            100                 105                 110         


Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr 
        115                 120                 125             


Met Gly Ala Glu Asp Val Glu Arg Gln Lys Met Asn Val Phe Arg Met 
    130                 135                 140                 


Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr 
145                 150                 155                 160 


Leu Lys Asp Ala Ile Asn Glu Ala Leu Arg Asp Trp Val Ala Thr Phe 
                165                 170                 175     


Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr 
            180                 185                 190         


Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys 
        195                 200                 205             


Ala Gln Ile Leu Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala 
    210                 215                 220                 


Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val 
225                 230                 235                 240 


Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly 
                245                 250                 255     


Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly 
            260                 265                 270         


Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln 
        275                 280                 285             


Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp Tyr Pro Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val 
305                 310                 315                 320 


Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg 
                325                 330                 335     


Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr 
            340                 345                 350         


Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val 
        355                 360                 365             


Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala 
    370                 375                 380                 


Ser Gly Asn Val Leu Glu His His His His His His 
385                 390                 395     


<210>  11
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pf2B9 L161V


<220>
<221>  CDS
<222>  (1)..(1164)

<400>  11
atg tgg ttc ggt gaa ttt ggt ggt cag tac gtg cca gaa acg ctg gtt         48
Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val           
1               5                   10                  15                

gga ccc ctg aaa gag ctg gaa aaa gct tac aaa cgt ttc aaa gat gac         96
Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp           
            20                  25                  30                    

gaa gaa ttc aat cgt cag ctg aat tac tac ctg aaa acc tgg gca ggt        144
Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly           
        35                  40                  45                        

cgt cca acc cca ctg tac tac gca aaa cgc ctg act gaa aaa atc ggt        192
Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly           
    50                  55                  60                            

ggt gct aaa gtc tac ctg aaa cgt gaa gac ctg gtt cac ggt ggt gca        240
Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala           
65                  70                  75                  80            

cac aag acc aac aac gcc atc ggt cag gca ctg ctg gca aag ctc atg        288
His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met           
                85                  90                  95                

ggt aaa act cgt ctg atc gct gag acc ggt gct ggt cag cac ggc gta        336
Gly Lys Thr Arg Leu Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val           
            100                 105                 110                   

gcg act gca atg gct ggt gca ctg ctg ggc atg aaa gtg gac att tac        384
Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr           
        115                 120                 125                       

atg ggt gct gag gac gta gaa cgt cag aaa atg aac gta ttc cgt atg        432
Met Gly Ala Glu Asp Val Glu Arg Gln Lys Met Asn Val Phe Arg Met           
    130                 135                 140                           

aag ctg ctg ggt gca aac gta att cca gtt aac tcc ggt tct cgc acc        480
Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr           
145                 150                 155                 160           

gtg aaa gac gca atc aac gag gct ctg cgt gat tgg gtg gct act ttt        528
Val Lys Asp Ala Ile Asn Glu Ala Leu Arg Asp Trp Val Ala Thr Phe           
                165                 170                 175               

gaa tac acc cac tac cta atc ggt tcc gtg gtc ggt cca cat ccg tat        576
Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr           
            180                 185                 190                   

ccg acc atc gtt cgt gat ttt cag tct gtt atc ggt cgt gag gct aaa        624
Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys           
        195                 200                 205                       

gcg cag atc ctg gag gct gaa ggt cag ctg cca gat gta atc gtt gct        672
Ala Gln Ile Leu Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala           
    210                 215                 220                           

tgt gtt ggt ggt ggc tct aac gcg atg ggt atc ttt tac ccg ttc gtg        720
Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val           
225                 230                 235                 240           

aac gac aaa aaa gtt aag ctg gtt ggc gtt gag gct ggt ggt aaa ggc        768
Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly           
                245                 250                 255               

ctg gaa tct ggt aag cat tcc gct agc ctg aac gca ggt cag gtt ggt        816
Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly           
            260                 265                 270                   

gtg tcc cat ggc atg ctg tcc tac ttt ctg cag gac gaa gaa ggt cag        864
Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln           
        275                 280                 285                       

atc aaa cca agc cac tcc atc gca cca ggt ctg gat tat cca ggt gtt        912
Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp Tyr Pro Gly Val           
    290                 295                 300                           

ggt cca gaa cac gct tac ctg aaa aaa att cag cgt gct gaa tac gtg        960
Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val           
305                 310                 315                 320           

gct gta acc gat gaa gaa gca ctg aaa gcg ttc cat gaa ctg agc cgt       1008
Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg           
                325                 330                 335               

acc gaa ggt atc atc cca gct ctg gaa tct gcg cat gct gtg gct tac       1056
Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr           
            340                 345                 350                   

gct atg aaa ctg gct aag gaa atg tct cgt gat gag atc atc atc gta       1104
Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val           
        355                 360                 365                       

aac ctg tct ggt cgt ggt gac aaa gac ctg gat att gtc ctg aaa gcg       1152
Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala           
    370                 375                 380                           

tct ggc aac gtg                                                       1164
Ser Gly Asn Val                                                           
385                                                                       


<210>  12
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  12

Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val 
1               5                   10                  15      


Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp 
            20                  25                  30          


Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly 
        35                  40                  45              


Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly 
    50                  55                  60                  


Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala 
65                  70                  75                  80  


His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met 
                85                  90                  95      


Gly Lys Thr Arg Leu Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val 
            100                 105                 110         


Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr 
        115                 120                 125             


Met Gly Ala Glu Asp Val Glu Arg Gln Lys Met Asn Val Phe Arg Met 
    130                 135                 140                 


Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr 
145                 150                 155                 160 


Val Lys Asp Ala Ile Asn Glu Ala Leu Arg Asp Trp Val Ala Thr Phe 
                165                 170                 175     


Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr 
            180                 185                 190         


Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys 
        195                 200                 205             


Ala Gln Ile Leu Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala 
    210                 215                 220                 


Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val 
225                 230                 235                 240 


Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly 
                245                 250                 255     


Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly 
            260                 265                 270         


Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln 
        275                 280                 285             


Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp Tyr Pro Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val 
305                 310                 315                 320 


Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg 
                325                 330                 335     


Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr 
            340                 345                 350         


Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val 
        355                 360                 365             


Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala 
    370                 375                 380                 


Ser Gly Asn Val 
385             


<210>  13
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pf5G8


<220>
<221>  CDS
<222>  (1)..(1164)

<400>  13
atg tgg ttc ggt gaa ttt ggt ggt cag tac gtg cca gaa acg ctg gtt         48
Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val           
1               5                   10                  15                

gga ccc ctg aaa gag ctg gaa aaa gct tac aaa cgt ttc aaa gat gac         96
Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp           
            20                  25                  30                    

gaa gaa ttc aat cgt cag ctg aat tac tac ctg aaa acc tgg gca ggt        144
Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly           
        35                  40                  45                        

cgt cca acc cca ctg tac tac gca aaa cgc ctg act gaa aaa atc ggt        192
Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly           
    50                  55                  60                            

ggt gct aaa gtc tac ctg aaa cgt gaa gac ctg gtt cac ggt ggt gca        240
Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala           
65                  70                  75                  80            

cac aag acc aac aac gcc atc ggt cag gca ctg ctg gca aag ctc atg        288
His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met           
                85                  90                  95                

ggt aaa act cgt ctg atc gct gag acc ggt gct ggt cag cac ggc gta        336
Gly Lys Thr Arg Leu Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val           
            100                 105                 110                   

gcg act gca atg gct ggt gca ctg ctg ggc atg aaa gtg gac att tac        384
Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr           
        115                 120                 125                       

atg ggt gct gag gac gta gaa cgt cag aaa ttg aac gta ttc cgt atg        432
Met Gly Ala Glu Asp Val Glu Arg Gln Lys Leu Asn Val Phe Arg Met           
    130                 135                 140                           

aag ctg ctg ggt gca aac gta att cca gtt aac tcc ggt tct cgc acc        480
Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr           
145                 150                 155                 160           

ctg aaa gac gca atc gac gag gct ctg cgt gat tgg gtg gct act ttt        528
Leu Lys Asp Ala Ile Asp Glu Ala Leu Arg Asp Trp Val Ala Thr Phe           
                165                 170                 175               

gaa tac acc cac tac cta atc ggt tcc gtg gtc ggt cca cat ccg tat        576
Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr           
            180                 185                 190                   

ccg acc atc gtt cgt gat ttt cag tct gtt atc ggt cgt gag gct aaa        624
Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys           
        195                 200                 205                       

gcg cag atc ccg gag gct gaa ggt cag ctg cca gat gta atc gtt gct        672
Ala Gln Ile Pro Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala           
    210                 215                 220                           

tgt gtt ggt ggt ggc tct aac gcg atg ggt atc ttt tac ccg ttc gtg        720
Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val           
225                 230                 235                 240           

aac gac aaa aaa gtt aag ctg gtt ggc gtt gag gct ggt ggt aaa ggc        768
Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly           
                245                 250                 255               

ctg gaa tct ggt aag cat tcc gct agc ctg aac gca ggt cag gtt ggt        816
Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly           
            260                 265                 270                   

gtg tcc cat ggc atg ctg tcc tac ttt ctg cag gac gaa gaa ggt cag        864
Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln           
        275                 280                 285                       

atc aaa cca agc cac tcc atc gca cca ggt ctg gat tat cca ggt gtt        912
Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp Tyr Pro Gly Val           
    290                 295                 300                           

ggt cca gaa cac gct tac ctg aaa aaa att cag cgt gct gaa tac gtg        960
Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val           
305                 310                 315                 320           

gct gta acc gat gaa gaa gca ctg aaa gcg ttc cat gaa ctg agc cgt       1008
Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg           
                325                 330                 335               

acc gaa ggt atc atc cca gct ctg gaa tct gcg cat gct gtg gct tac       1056
Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr           
            340                 345                 350                   

gct atg aaa ctg gct aag gaa atg tct cgt gat gag atc atc atc gta       1104
Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val           
        355                 360                 365                       

aac ctg tct ggt cgt ggt gac aaa gac ctg gat att gtc ctg aaa gcg       1152
Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala           
    370                 375                 380                           

tct ggc aac gtg                                                       1164
Ser Gly Asn Val                                                           
385                                                                       


<210>  14
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14

Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val 
1               5                   10                  15      


Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp 
            20                  25                  30          


Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly 
        35                  40                  45              


Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly 
    50                  55                  60                  


Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala 
65                  70                  75                  80  


His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met 
                85                  90                  95      


Gly Lys Thr Arg Leu Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val 
            100                 105                 110         


Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr 
        115                 120                 125             


Met Gly Ala Glu Asp Val Glu Arg Gln Lys Leu Asn Val Phe Arg Met 
    130                 135                 140                 


Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr 
145                 150                 155                 160 


Leu Lys Asp Ala Ile Asp Glu Ala Leu Arg Asp Trp Val Ala Thr Phe 
                165                 170                 175     


Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr 
            180                 185                 190         


Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys 
        195                 200                 205             


Ala Gln Ile Pro Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala 
    210                 215                 220                 


Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val 
225                 230                 235                 240 


Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly 
                245                 250                 255     


Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly 
            260                 265                 270         


Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln 
        275                 280                 285             


Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp Tyr Pro Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val 
305                 310                 315                 320 


Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg 
                325                 330                 335     


Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr 
            340                 345                 350         


Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val 
        355                 360                 365             


Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala 
    370                 375                 380                 


Ser Gly Asn Val 
385             


<210>  15
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pf5G8 E104G


<220>
<221>  CDS
<222>  (1)..(1164)

<400>  15
atg tgg ttc ggt gaa ttt ggt ggt cag tac gtg cca gaa acg ctg gtt         48
Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val           
1               5                   10                  15                

gga ccc ctg aaa gag ctg gaa aaa gct tac aaa cgt ttc aaa gat gac         96
Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp           
            20                  25                  30                    

gaa gaa ttc aat cgt cag ctg aat tac tac ctg aaa acc tgg gca ggt        144
Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly           
        35                  40                  45                        

cgt cca acc cca ctg tac tac gca aaa cgc ctg act gaa aaa atc ggt        192
Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly           
    50                  55                  60                            

ggt gct aaa gtc tac ctg aaa cgt gaa gac ctg gtt cac ggt ggt gca        240
Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala           
65                  70                  75                  80            

cac aag acc aac aac gcc atc ggt cag gca ctg ctg gca aag ctc atg        288
His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met           
                85                  90                  95                

ggt aaa act cgt ctg atc gct ggg acc ggt gct ggt cag cac ggc gta        336
Gly Lys Thr Arg Leu Ile Ala Gly Thr Gly Ala Gly Gln His Gly Val           
            100                 105                 110                   

gcg act gca atg gct ggt gca ctg ctg ggc atg aaa gtg gac att tac        384
Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr           
        115                 120                 125                       

atg ggt gct gag gac gta gaa cgt cag aaa ttg aac gta ttc cgt atg        432
Met Gly Ala Glu Asp Val Glu Arg Gln Lys Leu Asn Val Phe Arg Met           
    130                 135                 140                           

aag ctg ctg ggt gca aac gta att cca gtt aac tcc ggt tct cgc acc        480
Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr           
145                 150                 155                 160           

ctg aaa gac gca atc gac gag gct ctg cgt gat tgg gtg gct act ttt        528
Leu Lys Asp Ala Ile Asp Glu Ala Leu Arg Asp Trp Val Ala Thr Phe           
                165                 170                 175               

gaa tac acc cac tac cta atc ggt tcc gtg gtc ggt cca cat ccg tat        576
Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr           
            180                 185                 190                   

ccg acc atc gtt cgt gat ttt cag tct gtt atc ggt cgt gag gct aaa        624
Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys           
        195                 200                 205                       

gcg cag atc ccg gag gct gaa ggt cag ctg cca gat gta atc gtt gct        672
Ala Gln Ile Pro Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala           
    210                 215                 220                           

tgt gtt ggt ggt ggc tct aac gcg atg ggt atc ttt tac ccg ttc gtg        720
Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val           
225                 230                 235                 240           

aac gac aaa aaa gtt aag ctg gtt ggc gtt gag gct ggt ggt aaa ggc        768
Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly           
                245                 250                 255               

ctg gaa tct ggt aag cat tcc gct agc ctg aac gca ggt cag gtt ggt        816
Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly           
            260                 265                 270                   

gtg tcc cat ggc atg ctg tcc tac ttt ctg cag gac gaa gaa ggt cag        864
Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln           
        275                 280                 285                       

atc aaa cca agc cac tcc atc gca cca ggt ctg gat tat cca ggt gtt        912
Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp Tyr Pro Gly Val           
    290                 295                 300                           

ggt cca gaa cac gct tac ctg aaa aaa att cag cgt gct gaa tac gtg        960
Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val           
305                 310                 315                 320           

gct gta acc gat gaa gaa gca ctg aaa gcg ttc cat gaa ctg agc cgt       1008
Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg           
                325                 330                 335               

acc gaa ggt atc atc cca gct ctg gaa tct gcg cat gct gtg gct tac       1056
Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr           
            340                 345                 350                   

gct atg aaa ctg gct aag gaa atg tct cgt gat gag atc atc atc gta       1104
Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val           
        355                 360                 365                       

aac ctg tct ggt cgt ggt gac aaa gac ctg gat att gtc ctg aaa gcg       1152
Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala           
    370                 375                 380                           

tct ggc aac gtg                                                       1164
Ser Gly Asn Val                                                           
385                                                                       


<210>  16
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val 
1               5                   10                  15      


Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp 
            20                  25                  30          


Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly 
        35                  40                  45              


Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly 
    50                  55                  60                  


Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala 
65                  70                  75                  80  


His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met 
                85                  90                  95      


Gly Lys Thr Arg Leu Ile Ala Gly Thr Gly Ala Gly Gln His Gly Val 
            100                 105                 110         


Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr 
        115                 120                 125             


Met Gly Ala Glu Asp Val Glu Arg Gln Lys Leu Asn Val Phe Arg Met 
    130                 135                 140                 


Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr 
145                 150                 155                 160 


Leu Lys Asp Ala Ile Asp Glu Ala Leu Arg Asp Trp Val Ala Thr Phe 
                165                 170                 175     


Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr 
            180                 185                 190         


Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys 
        195                 200                 205             


Ala Gln Ile Pro Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala 
    210                 215                 220                 


Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val 
225                 230                 235                 240 


Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly 
                245                 250                 255     


Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly 
            260                 265                 270         


Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln 
        275                 280                 285             


Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp Tyr Pro Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val 
305                 310                 315                 320 


Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg 
                325                 330                 335     


Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr 
            340                 345                 350         


Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val 
        355                 360                 365             


Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala 
    370                 375                 380                 


Ser Gly Asn Val 
385             


<210>  17
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pf2A6


<220>
<221>  CDS
<222>  (1)..(1164)

<400>  17
atg tgg ttc ggt gaa ttt ggt ggt cag tac gtg cca gaa acg ctg gtt         48
Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val           
1               5                   10                  15                

gga ccc ctg aaa gag ctg gaa aaa gct tac aaa cgt ttc aaa gat gac         96
Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp           
            20                  25                  30                    

gaa gaa ttc aat cgt cag ctg aat tac tac ctg aaa acc tgg gca ggt        144
Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly           
        35                  40                  45                        

cgt cca acc cca ctg tac tac gca aaa cgc ctg act gaa aaa atc ggt        192
Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly           
    50                  55                  60                            

ggt gct aaa gtc tac ctg aaa cgt gaa gac ctg gtt cac ggt ggt gca        240
Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala           
65                  70                  75                  80            

cac aag acc aac aac gcc atc ggt cag gca ctg ctg gca aag ctc atg        288
His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met           
                85                  90                  95                

ggt aaa act cgt ctg atc gct ggg acc ggt gct ggt cag cac ggc gta        336
Gly Lys Thr Arg Leu Ile Ala Gly Thr Gly Ala Gly Gln His Gly Val           
            100                 105                 110                   

gcg act gca atg gct ggt gca ctg ctg ggc atg aaa gtg gac att tac        384
Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr           
        115                 120                 125                       

atg ggt gct gag gac gta gaa cgt cag aaa ttg aac gta ttc cgt atg        432
Met Gly Ala Glu Asp Val Glu Arg Gln Lys Leu Asn Val Phe Arg Met           
    130                 135                 140                           

aag ctg ctg ggt gca aac gta att cca gtt aac tcc ggt tct cgc acc        480
Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr           
145                 150                 155                 160           

ctg aaa gac gca atc gac gag gct ctg cgt gat tgg gtg gct act ttt        528
Leu Lys Asp Ala Ile Asp Glu Ala Leu Arg Asp Trp Val Ala Thr Phe           
                165                 170                 175               

gaa tac acc cac tac cta ttc ggt tcc gcg gtc ggt cca cat ccg tat        576
Glu Tyr Thr His Tyr Leu Phe Gly Ser Ala Val Gly Pro His Pro Tyr           
            180                 185                 190                   

ccg acc atc gtt cgt gat ttt cag tct gtt atc ggt cgt gag gct aaa        624
Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys           
        195                 200                 205                       

gcg cag atc ccg gag gct gaa ggt cag ctg cca gat gta atc gtt gct        672
Ala Gln Ile Pro Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala           
    210                 215                 220                           

tgt gtt ggt ggt ggc tct aac gcg atg ggt atc ttt tac ccg ttc gtg        720
Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val           
225                 230                 235                 240           

aac gac aaa aaa gtt aag ctg gtt ggc gtt gag gct ggt ggt aaa ggc        768
Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly           
                245                 250                 255               

ctg gaa tct ggt aag cat tcc gct agc ctg aac gca ggt cag gtt ggt        816
Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly           
            260                 265                 270                   

gtg tcc cat ggc atg ctg tcc tac ttt ctg cag gac gaa gaa ggt cag        864
Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln           
        275                 280                 285                       

atc aaa cca agc cac tcc atc gca cca ggt ctg gat tat cca ggt gtt        912
Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp Tyr Pro Gly Val           
    290                 295                 300                           

ggt cca gaa cac gct tac ctg aaa aaa att cag cgt gct gaa tac gtg        960
Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val           
305                 310                 315                 320           

gct gta acc gat gaa gaa gca ctg aaa gcg ttc cat gaa ctg agc cgt       1008
Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg           
                325                 330                 335               

acc gaa ggt atc atc cca gct ctg gaa tct gcg cat gct gtg gct tac       1056
Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr           
            340                 345                 350                   

gct atg aaa ctg gct aag gaa atg tct cgt gat gag atc atc atc gta       1104
Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val           
        355                 360                 365                       

aac ctg tct ggt cgt ggt gac aaa gac ctg gat att gtc ctg aaa gcg       1152
Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala           
    370                 375                 380                           

tct ggc aac gtg                                                       1164
Ser Gly Asn Val                                                           
385                                                                       


<210>  18
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val 
1               5                   10                  15      


Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp 
            20                  25                  30          


Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly 
        35                  40                  45              


Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly 
    50                  55                  60                  


Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala 
65                  70                  75                  80  


His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met 
                85                  90                  95      


Gly Lys Thr Arg Leu Ile Ala Gly Thr Gly Ala Gly Gln His Gly Val 
            100                 105                 110         


Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr 
        115                 120                 125             


Met Gly Ala Glu Asp Val Glu Arg Gln Lys Leu Asn Val Phe Arg Met 
    130                 135                 140                 


Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr 
145                 150                 155                 160 


Leu Lys Asp Ala Ile Asp Glu Ala Leu Arg Asp Trp Val Ala Thr Phe 
                165                 170                 175     


Glu Tyr Thr His Tyr Leu Phe Gly Ser Ala Val Gly Pro His Pro Tyr 
            180                 185                 190         


Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys 
        195                 200                 205             


Ala Gln Ile Pro Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala 
    210                 215                 220                 


Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val 
225                 230                 235                 240 


Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly 
                245                 250                 255     


Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly 
            260                 265                 270         


Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln 
        275                 280                 285             


Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp Tyr Pro Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val 
305                 310                 315                 320 


Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg 
                325                 330                 335     


Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr 
            340                 345                 350         


Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val 
        355                 360                 365             


Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala 
    370                 375                 380                 


Ser Gly Asn Val 
385             


<210>  19
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pf0A9


<220>
<221>  CDS
<222>  (1)..(1164)

<400>  19
atg tgg ttc ggt gaa ttt ggt ggt cag tac gtg cca gaa acg ctg gtt         48
Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val           
1               5                   10                  15                

gga ccc ctg aaa gag ctg gaa aaa gct tac aaa cgt ttc aaa gat gac         96
Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp           
            20                  25                  30                    

gaa gaa ttc aat cgt cag ctg aat tac tac ctg aaa acc tgg gca ggt        144
Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly           
        35                  40                  45                        

cgt cca acc cca ctg tac tac gca aaa cgc ctg act gaa aaa atc ggt        192
Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly           
    50                  55                  60                            

ggt gct aaa gtc tac ctg aaa cgt gaa gac ctg gtt cac ggt ggt gca        240
Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala           
65                  70                  75                  80            

cac aag acc aac aac gcc atc ggt cag gca ctg ctg gca aag ctc atg        288
His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met           
                85                  90                  95                

ggt aaa act cgt ctg atc gct gag acc ggt gct ggt cag cac ggc gta        336
Gly Lys Thr Arg Leu Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val           
            100                 105                 110                   

gcg act gca atg gct ggt gca ctg ctg ggc atg aaa gtg gac att tac        384
Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr           
        115                 120                 125                       

atg ggt gct gag gac gta gaa cgt cag aaa ctg aac gta ttc cgt atg        432
Met Gly Ala Glu Asp Val Glu Arg Gln Lys Leu Asn Val Phe Arg Met           
    130                 135                 140                           

aag ctg ctg ggt gca aac gta att cca gtt aac tcc ggt tct cgc acc        480
Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr           
145                 150                 155                 160           

ctg aaa gac gca ttt gac gag gct ctg cgt gat tgg gtg gct act ttt        528
Leu Lys Asp Ala Phe Asp Glu Ala Leu Arg Asp Trp Val Ala Thr Phe           
                165                 170                 175               

gaa tac acc cac tac cta atc ggt tcc gtg gtc ggt cca cat ccg tat        576
Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr           
            180                 185                 190                   

ccg acc atc gtt cgt gat ttt cag tct gtt atc ggt cgt gag gct aaa        624
Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys           
        195                 200                 205                       

gcg cag atc ctg gag gct gaa ggt cag ctg cca gat gta atc gtt gct        672
Ala Gln Ile Leu Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala           
    210                 215                 220                           

tgt gtt ggt ggt ggc tct aac gcg atg ggt atc ttt tac ccg ttc gtg        720
Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val           
225                 230                 235                 240           

aac gac aaa aaa gtt aag ctg gtt ggc gtt gag gct ggt ggt aaa ggc        768
Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly           
                245                 250                 255               

ctg gaa tct ggt aag cat tcc gct agc ctg aac gca ggt cag gtt ggt        816
Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly           
            260                 265                 270                   

gtg tcc cat ggc atg ctg tcc tac ttt ctg cag gac gaa gaa ggt cag        864
Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln           
        275                 280                 285                       

atc aaa cca agc cac tcc atc gca cca ggt ctg gat cat cca ggt gtt        912
Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp His Pro Gly Val           
    290                 295                 300                           

ggt cca gaa cac gct tac ctg aaa aaa att cag cgt gct gaa tac gtg        960
Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val           
305                 310                 315                 320           

gct gta acc gat gaa gaa gca ctg aaa gcg ttc cat gaa ctg agc cgt       1008
Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg           
                325                 330                 335               

acc gaa ggt atc atc cca gct ctg gaa tct gcg cat gct gtg gct tac       1056
Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr           
            340                 345                 350                   

gct atg aaa ctg gct aag gaa atg tct cgt gat gag atc atc atc gta       1104
Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val           
        355                 360                 365                       

aac ctg tct ggt cgt ggt gac aaa gac ctg gat att gtc ctg aaa gcg       1152
Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala           
    370                 375                 380                           

tct ggc aac gtg                                                       1164
Ser Gly Asn Val                                                           
385                                                                       


<210>  20
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val 
1               5                   10                  15      


Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp 
            20                  25                  30          


Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly 
        35                  40                  45              


Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly 
    50                  55                  60                  


Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala 
65                  70                  75                  80  


His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met 
                85                  90                  95      


Gly Lys Thr Arg Leu Ile Ala Glu Thr Gly Ala Gly Gln His Gly Val 
            100                 105                 110         


Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr 
        115                 120                 125             


Met Gly Ala Glu Asp Val Glu Arg Gln Lys Leu Asn Val Phe Arg Met 
    130                 135                 140                 


Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr 
145                 150                 155                 160 


Leu Lys Asp Ala Phe Asp Glu Ala Leu Arg Asp Trp Val Ala Thr Phe 
                165                 170                 175     


Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr 
            180                 185                 190         


Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys 
        195                 200                 205             


Ala Gln Ile Leu Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala 
    210                 215                 220                 


Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val 
225                 230                 235                 240 


Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly 
                245                 250                 255     


Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly 
            260                 265                 270         


Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln 
        275                 280                 285             


Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp His Pro Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val 
305                 310                 315                 320 


Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg 
                325                 330                 335     


Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr 
            340                 345                 350         


Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val 
        355                 360                 365             


Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala 
    370                 375                 380                 


Ser Gly Asn Val 
385             


<210>  21
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Pf0A9 E104G


<220>
<221>  CDS
<222>  (1)..(1164)

<400>  21
atg tgg ttc ggt gaa ttt ggt ggt cag tac gtg cca gaa acg ctg gtt         48
Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val           
1               5                   10                  15                

gga ccc ctg aaa gag ctg gaa aaa gct tac aaa cgt ttc aaa gat gac         96
Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp           
            20                  25                  30                    

gaa gaa ttc aat cgt cag ctg aat tac tac ctg aaa acc tgg gca ggt        144
Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly           
        35                  40                  45                        

cgt cca acc cca ctg tac tac gca aaa cgc ctg act gaa aaa atc ggt        192
Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly           
    50                  55                  60                            

ggt gct aaa gtc tac ctg aaa cgt gaa gac ctg gtt cac ggt ggt gca        240
Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala           
65                  70                  75                  80            

cac aag acc aac aac gcc atc ggt cag gca ctg ctg gca aag ctc atg        288
His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met           
                85                  90                  95                

ggt aaa act cgt ctg atc gct ggg acc ggt gct ggt cag cac ggc gta        336
Gly Lys Thr Arg Leu Ile Ala Gly Thr Gly Ala Gly Gln His Gly Val           
            100                 105                 110                   

gcg act gca atg gct ggt gca ctg ctg ggc atg aaa gtg gac att tac        384
Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr           
        115                 120                 125                       

atg ggt gct gag gac gta gaa cgt cag aaa ctg aac gta ttc cgt atg        432
Met Gly Ala Glu Asp Val Glu Arg Gln Lys Leu Asn Val Phe Arg Met           
    130                 135                 140                           

aag ctg ctg ggt gca aac gta att cca gtt aac tcc ggt tct cgc acc        480
Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr           
145                 150                 155                 160           

ctg aaa gac gca ttt gac gag gct ctg cgt gat tgg gtg gct act ttt        528
Leu Lys Asp Ala Phe Asp Glu Ala Leu Arg Asp Trp Val Ala Thr Phe           
                165                 170                 175               

gaa tac acc cac tac cta atc ggt tcc gtg gtc ggt cca cat ccg tat        576
Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr           
            180                 185                 190                   

ccg acc atc gtt cgt gat ttt cag tct gtt atc ggt cgt gag gct aaa        624
Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys           
        195                 200                 205                       

gcg cag atc ctg gag gct gaa ggt cag ctg cca gat gta atc gtt gct        672
Ala Gln Ile Leu Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala           
    210                 215                 220                           

tgt gtt ggt ggt ggc tct aac gcg atg ggt atc ttt tac ccg ttc gtg        720
Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val           
225                 230                 235                 240           

aac gac aaa aaa gtt aag ctg gtt ggc gtt gag gct ggt ggt aaa ggc        768
Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly           
                245                 250                 255               

ctg gaa tct ggt aag cat tcc gct agc ctg aac gca ggt cag gtt ggt        816
Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly           
            260                 265                 270                   

gtg tcc cat ggc atg ctg tcc tac ttt ctg cag gac gaa gaa ggt cag        864
Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln           
        275                 280                 285                       

atc aaa cca agc cac tcc atc gca cca ggt ctg gat cat cca ggt gtt        912
Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp His Pro Gly Val           
    290                 295                 300                           

ggt cca gaa cac gct tac ctg aaa aaa att cag cgt gct gaa tac gtg        960
Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val           
305                 310                 315                 320           

gct gta acc gat gaa gaa gca ctg aaa gcg ttc cat gaa ctg agc cgt       1008
Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg           
                325                 330                 335               

acc gaa ggt atc atc cca gct ctg gaa tct gcg cat gct gtg gct tac       1056
Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr           
            340                 345                 350                   

gct atg aaa ctg gct aag gaa atg tct cgt gat gag atc atc atc gta       1104
Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val           
        355                 360                 365                       

aac ctg tct ggt cgt ggt gac aaa gac ctg gat att gtc ctg aaa gcg       1152
Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala           
    370                 375                 380                           

tct ggc aac gtg                                                       1164
Ser Gly Asn Val                                                           
385                                                                       


<210>  22
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Trp Phe Gly Glu Phe Gly Gly Gln Tyr Val Pro Glu Thr Leu Val 
1               5                   10                  15      


Gly Pro Leu Lys Glu Leu Glu Lys Ala Tyr Lys Arg Phe Lys Asp Asp 
            20                  25                  30          


Glu Glu Phe Asn Arg Gln Leu Asn Tyr Tyr Leu Lys Thr Trp Ala Gly 
        35                  40                  45              


Arg Pro Thr Pro Leu Tyr Tyr Ala Lys Arg Leu Thr Glu Lys Ile Gly 
    50                  55                  60                  


Gly Ala Lys Val Tyr Leu Lys Arg Glu Asp Leu Val His Gly Gly Ala 
65                  70                  75                  80  


His Lys Thr Asn Asn Ala Ile Gly Gln Ala Leu Leu Ala Lys Leu Met 
                85                  90                  95      


Gly Lys Thr Arg Leu Ile Ala Gly Thr Gly Ala Gly Gln His Gly Val 
            100                 105                 110         


Ala Thr Ala Met Ala Gly Ala Leu Leu Gly Met Lys Val Asp Ile Tyr 
        115                 120                 125             


Met Gly Ala Glu Asp Val Glu Arg Gln Lys Leu Asn Val Phe Arg Met 
    130                 135                 140                 


Lys Leu Leu Gly Ala Asn Val Ile Pro Val Asn Ser Gly Ser Arg Thr 
145                 150                 155                 160 


Leu Lys Asp Ala Phe Asp Glu Ala Leu Arg Asp Trp Val Ala Thr Phe 
                165                 170                 175     


Glu Tyr Thr His Tyr Leu Ile Gly Ser Val Val Gly Pro His Pro Tyr 
            180                 185                 190         


Pro Thr Ile Val Arg Asp Phe Gln Ser Val Ile Gly Arg Glu Ala Lys 
        195                 200                 205             


Ala Gln Ile Leu Glu Ala Glu Gly Gln Leu Pro Asp Val Ile Val Ala 
    210                 215                 220                 


Cys Val Gly Gly Gly Ser Asn Ala Met Gly Ile Phe Tyr Pro Phe Val 
225                 230                 235                 240 


Asn Asp Lys Lys Val Lys Leu Val Gly Val Glu Ala Gly Gly Lys Gly 
                245                 250                 255     


Leu Glu Ser Gly Lys His Ser Ala Ser Leu Asn Ala Gly Gln Val Gly 
            260                 265                 270         


Val Ser His Gly Met Leu Ser Tyr Phe Leu Gln Asp Glu Glu Gly Gln 
        275                 280                 285             


Ile Lys Pro Ser His Ser Ile Ala Pro Gly Leu Asp His Pro Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Leu Lys Lys Ile Gln Arg Ala Glu Tyr Val 
305                 310                 315                 320 


Ala Val Thr Asp Glu Glu Ala Leu Lys Ala Phe His Glu Leu Ser Arg 
                325                 330                 335     


Thr Glu Gly Ile Ile Pro Ala Leu Glu Ser Ala His Ala Val Ala Tyr 
            340                 345                 350         


Ala Met Lys Leu Ala Lys Glu Met Ser Arg Asp Glu Ile Ile Ile Val 
        355                 360                 365             


Asn Leu Ser Gly Arg Gly Asp Lys Asp Leu Asp Ile Val Leu Lys Ala 
    370                 375                 380                 


Ser Gly Asn Val 
385             


<210>  23
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tm2F3


<220>
<221>  CDS
<222>  (1)..(1167)

<400>  23
atg aaa ggc tac ttc ggt ccg tac ggt ggc cag tac gtg ccg gaa atc         48
Met Lys Gly Tyr Phe Gly Pro Tyr Gly Gly Gln Tyr Val Pro Glu Ile           
1               5                   10                  15                

ctg atg gga gct ctg gaa gaa ctg gaa gct gcg tac gaa gaa atc atg         96
Leu Met Gly Ala Leu Glu Glu Leu Glu Ala Ala Tyr Glu Glu Ile Met           
            20                  25                  30                    

aaa gat gag tct ttc tgg aaa gaa ttc aat gac ctg ctg cgc gat tat        144
Lys Asp Glu Ser Phe Trp Lys Glu Phe Asn Asp Leu Leu Arg Asp Tyr           
        35                  40                  45                        

gcg ggt cgt ccg act ccg ctg tac ttc gca cgt cgt ctg tcc gaa aaa        192
Ala Gly Arg Pro Thr Pro Leu Tyr Phe Ala Arg Arg Leu Ser Glu Lys           
    50                  55                  60                            

tac ggt gct cgc gta tat ctg aaa cgt gaa gac ctg ctg cat act ggt        240
Tyr Gly Ala Arg Val Tyr Leu Lys Arg Glu Asp Leu Leu His Thr Gly           
65                  70                  75                  80            

gcg cat aaa atc aat aac gct atc ggc cag gtt ctg ctg gca aaa cta        288
Ala His Lys Ile Asn Asn Ala Ile Gly Gln Val Leu Leu Ala Lys Leu           
                85                  90                  95                

atg ggc aaa acc cgt atc att gct gaa acg ggt gct ggt cag cac ggc        336
Met Gly Lys Thr Arg Ile Ile Ala Glu Thr Gly Ala Gly Gln His Gly           
            100                 105                 110                   

gta gca act gct acc gca gca gcg ctg ttc ggt atg gaa tgt gta atc        384
Val Ala Thr Ala Thr Ala Ala Ala Leu Phe Gly Met Glu Cys Val Ile           
        115                 120                 125                       

tat atg ggc gaa gaa gac acg atc cgc cag aaa cta aac gtt gaa cgt        432
Tyr Met Gly Glu Glu Asp Thr Ile Arg Gln Lys Leu Asn Val Glu Arg           
    130                 135                 140                           

atg aaa ctg ctg ggt gct aaa gtt gta ccg gta aaa tcc ggt agc cgt        480
Met Lys Leu Leu Gly Ala Lys Val Val Pro Val Lys Ser Gly Ser Arg           
145                 150                 155                 160           

acc ctg aaa gac gca att gac gaa gct ctg cgt gac tgg att acc aac        528
Thr Leu Lys Asp Ala Ile Asp Glu Ala Leu Arg Asp Trp Ile Thr Asn           
                165                 170                 175               

ctg cag acc acc tat tac gtg atc ggc tct gtg gtt ggt ccg cat cca        576
Leu Gln Thr Thr Tyr Tyr Val Ile Gly Ser Val Val Gly Pro His Pro           
            180                 185                 190                   

tat ccg att atc gta cgt aac ttc caa aag gtt atc ggc gaa gag acc        624
Tyr Pro Ile Ile Val Arg Asn Phe Gln Lys Val Ile Gly Glu Glu Thr           
        195                 200                 205                       

aaa aaa cag att cca gaa aaa gaa ggc cgt ctg ccg gac tac atc gtt        672
Lys Lys Gln Ile Pro Glu Lys Glu Gly Arg Leu Pro Asp Tyr Ile Val           
    210                 215                 220                           

gcg tgc gtg ggt ggt ggt tct aac gct gcc ggt atc ttc tat ccg ttt        720
Ala Cys Val Gly Gly Gly Ser Asn Ala Ala Gly Ile Phe Tyr Pro Phe           
225                 230                 235                 240           

atc gat tct ggt gtg aag ctg atc ggc gta gaa gcc ggt ggc gaa ggt        768
Ile Asp Ser Gly Val Lys Leu Ile Gly Val Glu Ala Gly Gly Glu Gly           
                245                 250                 255               

ctg gaa acc ggt aaa cat gcg gct tct ctg ctg aaa ggt aaa atc ggc        816
Leu Glu Thr Gly Lys His Ala Ala Ser Leu Leu Lys Gly Lys Ile Gly           
            260                 265                 270                   

tac ctg cac ggt tct aag acg ttc gtt ctg cag gat gac tgg ggt caa        864
Tyr Leu His Gly Ser Lys Thr Phe Val Leu Gln Asp Asp Trp Gly Gln           
        275                 280                 285                       

gtt cag gtg agc cac tcc gtc tcc gct ggc ctg gac tac tcc ggt gtc        912
Val Gln Val Ser His Ser Val Ser Ala Gly Leu Asp Tyr Ser Gly Val           
    290                 295                 300                           

ggt ccg gaa cac gcc tat tgg cgt gag acc ggt aaa gtg ctg tac gat        960
Gly Pro Glu His Ala Tyr Trp Arg Glu Thr Gly Lys Val Leu Tyr Asp           
305                 310                 315                 320           

gct gtg acc gat gaa gaa gct ctg gac gca ttc atc gaa ctg tct cgc       1008
Ala Val Thr Asp Glu Glu Ala Leu Asp Ala Phe Ile Glu Leu Ser Arg           
                325                 330                 335               

ctg gaa ggc atc atc cca gcc ctg gag tct tct cac gca ctg gct tat       1056
Leu Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser His Ala Leu Ala Tyr           
            340                 345                 350                   

ctg aag aag atc aac atc aag ggt aaa gtt gtg gtg gtt aat ctg tct       1104
Leu Lys Lys Ile Asn Ile Lys Gly Lys Val Val Val Val Asn Leu Ser           
        355                 360                 365                       

ggt cgt ggt gac aag gat ctg gaa tct gta ctg aac cac ccg tat gtt       1152
Gly Arg Gly Asp Lys Asp Leu Glu Ser Val Leu Asn His Pro Tyr Val           
    370                 375                 380                           

cgc gaa cgc atc cgc                                                   1167
Arg Glu Arg Ile Arg                                                       
385                                                                       


<210>  24
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Lys Gly Tyr Phe Gly Pro Tyr Gly Gly Gln Tyr Val Pro Glu Ile 
1               5                   10                  15      


Leu Met Gly Ala Leu Glu Glu Leu Glu Ala Ala Tyr Glu Glu Ile Met 
            20                  25                  30          


Lys Asp Glu Ser Phe Trp Lys Glu Phe Asn Asp Leu Leu Arg Asp Tyr 
        35                  40                  45              


Ala Gly Arg Pro Thr Pro Leu Tyr Phe Ala Arg Arg Leu Ser Glu Lys 
    50                  55                  60                  


Tyr Gly Ala Arg Val Tyr Leu Lys Arg Glu Asp Leu Leu His Thr Gly 
65                  70                  75                  80  


Ala His Lys Ile Asn Asn Ala Ile Gly Gln Val Leu Leu Ala Lys Leu 
                85                  90                  95      


Met Gly Lys Thr Arg Ile Ile Ala Glu Thr Gly Ala Gly Gln His Gly 
            100                 105                 110         


Val Ala Thr Ala Thr Ala Ala Ala Leu Phe Gly Met Glu Cys Val Ile 
        115                 120                 125             


Tyr Met Gly Glu Glu Asp Thr Ile Arg Gln Lys Leu Asn Val Glu Arg 
    130                 135                 140                 


Met Lys Leu Leu Gly Ala Lys Val Val Pro Val Lys Ser Gly Ser Arg 
145                 150                 155                 160 


Thr Leu Lys Asp Ala Ile Asp Glu Ala Leu Arg Asp Trp Ile Thr Asn 
                165                 170                 175     


Leu Gln Thr Thr Tyr Tyr Val Ile Gly Ser Val Val Gly Pro His Pro 
            180                 185                 190         


Tyr Pro Ile Ile Val Arg Asn Phe Gln Lys Val Ile Gly Glu Glu Thr 
        195                 200                 205             


Lys Lys Gln Ile Pro Glu Lys Glu Gly Arg Leu Pro Asp Tyr Ile Val 
    210                 215                 220                 


Ala Cys Val Gly Gly Gly Ser Asn Ala Ala Gly Ile Phe Tyr Pro Phe 
225                 230                 235                 240 


Ile Asp Ser Gly Val Lys Leu Ile Gly Val Glu Ala Gly Gly Glu Gly 
                245                 250                 255     


Leu Glu Thr Gly Lys His Ala Ala Ser Leu Leu Lys Gly Lys Ile Gly 
            260                 265                 270         


Tyr Leu His Gly Ser Lys Thr Phe Val Leu Gln Asp Asp Trp Gly Gln 
        275                 280                 285             


Val Gln Val Ser His Ser Val Ser Ala Gly Leu Asp Tyr Ser Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Trp Arg Glu Thr Gly Lys Val Leu Tyr Asp 
305                 310                 315                 320 


Ala Val Thr Asp Glu Glu Ala Leu Asp Ala Phe Ile Glu Leu Ser Arg 
                325                 330                 335     


Leu Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser His Ala Leu Ala Tyr 
            340                 345                 350         


Leu Lys Lys Ile Asn Ile Lys Gly Lys Val Val Val Val Asn Leu Ser 
        355                 360                 365             


Gly Arg Gly Asp Lys Asp Leu Glu Ser Val Leu Asn His Pro Tyr Val 
    370                 375                 380                 


Arg Glu Arg Ile Arg 
385                 


<210>  25
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Tm2F3 I184F


<220>
<221>  CDS
<222>  (1)..(1167)

<400>  25
atg aaa ggc tac ttc ggt ccg tac ggt ggc cag tac gtg ccg gaa atc         48
Met Lys Gly Tyr Phe Gly Pro Tyr Gly Gly Gln Tyr Val Pro Glu Ile           
1               5                   10                  15                

ctg atg gga gct ctg gaa gaa ctg gaa gct gcg tac gaa gaa atc atg         96
Leu Met Gly Ala Leu Glu Glu Leu Glu Ala Ala Tyr Glu Glu Ile Met           
            20                  25                  30                    

aaa gat gag tct ttc tgg aaa gaa ttc aat gac ctg ctg cgc gat tat        144
Lys Asp Glu Ser Phe Trp Lys Glu Phe Asn Asp Leu Leu Arg Asp Tyr           
        35                  40                  45                        

gcg ggt cgt ccg act ccg ctg tac ttc gca cgt cgt ctg tcc gaa aaa        192
Ala Gly Arg Pro Thr Pro Leu Tyr Phe Ala Arg Arg Leu Ser Glu Lys           
    50                  55                  60                            

tac ggt gct cgc gta tat ctg aaa cgt gaa gac ctg ctg cat act ggt        240
Tyr Gly Ala Arg Val Tyr Leu Lys Arg Glu Asp Leu Leu His Thr Gly           
65                  70                  75                  80            

gcg cat aaa atc aat aac gct atc ggc cag gtt ctg ctg gca aaa cta        288
Ala His Lys Ile Asn Asn Ala Ile Gly Gln Val Leu Leu Ala Lys Leu           
                85                  90                  95                

atg ggc aaa acc cgt atc att gct gaa acg ggt gct ggt cag cac ggc        336
Met Gly Lys Thr Arg Ile Ile Ala Glu Thr Gly Ala Gly Gln His Gly           
            100                 105                 110                   

gta gca act gct acc gca gca gcg ctg ttc ggt atg gaa tgt gta atc        384
Val Ala Thr Ala Thr Ala Ala Ala Leu Phe Gly Met Glu Cys Val Ile           
        115                 120                 125                       

tat atg ggc gaa gaa gac acg atc cgc cag aaa cta aac gtt gaa cgt        432
Tyr Met Gly Glu Glu Asp Thr Ile Arg Gln Lys Leu Asn Val Glu Arg           
    130                 135                 140                           

atg aaa ctg ctg ggt gct aaa gtt gta ccg gta aaa tcc ggt agc cgt        480
Met Lys Leu Leu Gly Ala Lys Val Val Pro Val Lys Ser Gly Ser Arg           
145                 150                 155                 160           

acc ctg aaa gac gca att gac gaa gct ctg cgt gac tgg att acc aac        528
Thr Leu Lys Asp Ala Ile Asp Glu Ala Leu Arg Asp Trp Ile Thr Asn           
                165                 170                 175               

ctg cag acc acc tat tac gtg ttc ggc tct gtg gtt ggt ccg cat cca        576
Leu Gln Thr Thr Tyr Tyr Val Phe Gly Ser Val Val Gly Pro His Pro           
            180                 185                 190                   

tat ccg att atc gta cgt aac ttc caa aag gtt atc ggc gaa gag acc        624
Tyr Pro Ile Ile Val Arg Asn Phe Gln Lys Val Ile Gly Glu Glu Thr           
        195                 200                 205                       

aaa aaa cag att cca gaa aaa gaa ggc cgt ctg ccg gac tac atc gtt        672
Lys Lys Gln Ile Pro Glu Lys Glu Gly Arg Leu Pro Asp Tyr Ile Val           
    210                 215                 220                           

gcg tgc gtg ggt ggt ggt tct aac gct gcc ggt atc ttc tat ccg ttt        720
Ala Cys Val Gly Gly Gly Ser Asn Ala Ala Gly Ile Phe Tyr Pro Phe           
225                 230                 235                 240           

atc gat tct ggt gtg aag ctg atc ggc gta gaa gcc ggt ggc gaa ggt        768
Ile Asp Ser Gly Val Lys Leu Ile Gly Val Glu Ala Gly Gly Glu Gly           
                245                 250                 255               

ctg gaa acc ggt aaa cat gcg gct tct ctg ctg aaa ggt aaa atc ggc        816
Leu Glu Thr Gly Lys His Ala Ala Ser Leu Leu Lys Gly Lys Ile Gly           
            260                 265                 270                   

tac ctg cac ggt tct aag acg ttc gtt ctg cag gat gac tgg ggt caa        864
Tyr Leu His Gly Ser Lys Thr Phe Val Leu Gln Asp Asp Trp Gly Gln           
        275                 280                 285                       

gtt cag gtg agc cac tcc gtc tcc gct ggc ctg gac tac tcc ggt gtc        912
Val Gln Val Ser His Ser Val Ser Ala Gly Leu Asp Tyr Ser Gly Val           
    290                 295                 300                           

ggt ccg gaa cac gcc tat tgg cgt gag acc ggt aaa gtg ctg tac gat        960
Gly Pro Glu His Ala Tyr Trp Arg Glu Thr Gly Lys Val Leu Tyr Asp           
305                 310                 315                 320           

gct gtg acc gat gaa gaa gct ctg gac gca ttc atc gaa ctg tct cgc       1008
Ala Val Thr Asp Glu Glu Ala Leu Asp Ala Phe Ile Glu Leu Ser Arg           
                325                 330                 335               

ctg gaa ggc atc atc cca gcc ctg gag tct tct cac gca ctg gct tat       1056
Leu Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser His Ala Leu Ala Tyr           
            340                 345                 350                   

ctg aag aag atc aac atc aag ggt aaa gtt gtg gtg gtt aat ctg tct       1104
Leu Lys Lys Ile Asn Ile Lys Gly Lys Val Val Val Val Asn Leu Ser           
        355                 360                 365                       

ggt cgt ggt gac aag gat ctg gaa tct gta ctg aac cac ccg tat gtt       1152
Gly Arg Gly Asp Lys Asp Leu Glu Ser Val Leu Asn His Pro Tyr Val           
    370                 375                 380                           

cgc gaa cgc atc cgc                                                   1167
Arg Glu Arg Ile Arg                                                       
385                                                                       


<210>  26
<211>  389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Met Lys Gly Tyr Phe Gly Pro Tyr Gly Gly Gln Tyr Val Pro Glu Ile 
1               5                   10                  15      


Leu Met Gly Ala Leu Glu Glu Leu Glu Ala Ala Tyr Glu Glu Ile Met 
            20                  25                  30          


Lys Asp Glu Ser Phe Trp Lys Glu Phe Asn Asp Leu Leu Arg Asp Tyr 
        35                  40                  45              


Ala Gly Arg Pro Thr Pro Leu Tyr Phe Ala Arg Arg Leu Ser Glu Lys 
    50                  55                  60                  


Tyr Gly Ala Arg Val Tyr Leu Lys Arg Glu Asp Leu Leu His Thr Gly 
65                  70                  75                  80  


Ala His Lys Ile Asn Asn Ala Ile Gly Gln Val Leu Leu Ala Lys Leu 
                85                  90                  95      


Met Gly Lys Thr Arg Ile Ile Ala Glu Thr Gly Ala Gly Gln His Gly 
            100                 105                 110         


Val Ala Thr Ala Thr Ala Ala Ala Leu Phe Gly Met Glu Cys Val Ile 
        115                 120                 125             


Tyr Met Gly Glu Glu Asp Thr Ile Arg Gln Lys Leu Asn Val Glu Arg 
    130                 135                 140                 


Met Lys Leu Leu Gly Ala Lys Val Val Pro Val Lys Ser Gly Ser Arg 
145                 150                 155                 160 


Thr Leu Lys Asp Ala Ile Asp Glu Ala Leu Arg Asp Trp Ile Thr Asn 
                165                 170                 175     


Leu Gln Thr Thr Tyr Tyr Val Phe Gly Ser Val Val Gly Pro His Pro 
            180                 185                 190         


Tyr Pro Ile Ile Val Arg Asn Phe Gln Lys Val Ile Gly Glu Glu Thr 
        195                 200                 205             


Lys Lys Gln Ile Pro Glu Lys Glu Gly Arg Leu Pro Asp Tyr Ile Val 
    210                 215                 220                 


Ala Cys Val Gly Gly Gly Ser Asn Ala Ala Gly Ile Phe Tyr Pro Phe 
225                 230                 235                 240 


Ile Asp Ser Gly Val Lys Leu Ile Gly Val Glu Ala Gly Gly Glu Gly 
                245                 250                 255     


Leu Glu Thr Gly Lys His Ala Ala Ser Leu Leu Lys Gly Lys Ile Gly 
            260                 265                 270         


Tyr Leu His Gly Ser Lys Thr Phe Val Leu Gln Asp Asp Trp Gly Gln 
        275                 280                 285             


Val Gln Val Ser His Ser Val Ser Ala Gly Leu Asp Tyr Ser Gly Val 
    290                 295                 300                 


Gly Pro Glu His Ala Tyr Trp Arg Glu Thr Gly Lys Val Leu Tyr Asp 
305                 310                 315                 320 


Ala Val Thr Asp Glu Glu Ala Leu Asp Ala Phe Ile Glu Leu Ser Arg 
                325                 330                 335     


Leu Glu Gly Ile Ile Pro Ala Leu Glu Ser Ser His Ala Leu Ala Tyr 
            340                 345                 350         


Leu Lys Lys Ile Asn Ile Lys Gly Lys Val Val Val Val Asn Leu Ser 
        355                 360                 365             


Gly Arg Gly Asp Lys Asp Leu Glu Ser Val Leu Asn His Pro Tyr Val 
    370                 375                 380                 


Arg Glu Arg Ile Arg 
385                 


