                         SEQUENCE LISTING

<110>  Bionomics Limited
 
<120>  Antibody and checkpoint inhibitor combination therapy

<130>  WJP35271563

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Heavy Chain CDR1

<400>  1

Gly Leu Tyr Thr Tyr Arg Thr His Arg Pro His Glu Ser Glu Arg Gly 
1               5                   10                  15      


Leu Tyr Thr Tyr Arg Thr Arg Pro 
            20                  


<210>  2
<211>  22
<212>  PRT
<213>  mus musculus


<220>
<221>  MISC_FEATURE
<223>  18G7.1 Heavy Chain CDR2 Amino Acid

<400>  2

Ile Leu Glu Leu Glu Pro Arg Gly Leu Tyr Ser Glu Arg Ala Ser Pro 
1               5                   10                  15      


Ser Glu Arg Thr His Arg 
            20          


<210>  3
<211>  33
<212>  PRT
<213>  mus musculus


<220>
<221>  MISC_FEATURE
<223>  Heavy Chain CDR3

<400>  3

Ala Leu Ala Ala Arg Gly Ser Glu Arg Gly Leu Tyr Thr Tyr Arg Thr 
1               5                   10                  15      


Tyr Arg Gly Leu Tyr Ser Glu Arg Ser Glu Arg Gly Leu Asn Thr Tyr 
            20                  25                  30          


Arg 
    


<210>  4
<211>  29
<212>  PRT
<213>  mus musculus


<220>
<221>  MISC_FEATURE
<223>  Light Chain CDR1

<400>  4

Gly Leu Ser Glu Arg Val Ala Leu Ala Ser Pro Ser Glu Arg Thr Tyr 
1               5                   10                  15      


Arg Gly Leu Tyr Ala Ser Asn Ser Glu Arg Pro His Glu 
            20                  25                  


<210>  5
<211>  8
<212>  PRT
<213>  mus musculus


<220>
<221>  MISC_FEATURE
<223>  Light Chain CDR2

<400>  5

Leu Glu Thr His Arg Ser Glu Arg 
1               5               


<210>  6
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  Light Chain CDR3

<400>  6

Gly Leu Asn Gly Leu Asn Ala Ser Asn Ala Leu Ala Gly Leu Ala Ser 
1               5                   10                  15      


Pro Pro Arg Ala Arg Gly Thr His Arg 
            20                  25  


<210>  7
<211>  391
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  Heavy Chain Variable Domain

<400>  7

Met Glu Thr Gly Leu Thr Arg Pro Ser Glu Arg Thr Arg Pro Val Ala 
1               5                   10                  15      


Leu Pro His Glu Leu Glu Pro His Glu Pro His Glu Leu Glu Ser Glu 
            20                  25                  30          


Arg Val Ala Leu Thr His Arg Thr His Arg Gly Leu Tyr Val Ala Leu 
        35                  40                  45              


His Ile Ser Ser Glu Arg Gly Leu Val Ala Leu Gly Leu Asn Leu Glu 
    50                  55                  60                  


Val Ala Leu Gly Leu Asn Ser Glu Arg Gly Leu Tyr Ala Leu Ala Gly 
65                  70                  75                  80  


Leu Val Ala Leu Leu Tyr Ser Leu Tyr Ser Pro Arg Gly Leu Tyr Gly 
                85                  90                  95      


Leu Ser Glu Arg Leu Glu Ala Arg Gly Ile Leu Glu Ser Glu Arg Cys 
            100                 105                 110         


Tyr Ser Leu Tyr Ser Gly Leu Tyr Ser Glu Arg Gly Leu Tyr Thr Tyr 
        115                 120                 125             


Arg Ser Glu Arg Pro His Glu Thr His Arg Ala Leu Ala Thr Tyr Arg 
    130                 135                 140                 


Thr Arg Pro Ile Leu Glu Gly Leu Thr Arg Pro Val Ala Leu Ala Arg 
145                 150                 155                 160 


Gly Gly Leu Asn Ala Leu Ala Pro Arg Gly Leu Tyr Leu Tyr Ser Gly 
                165                 170                 175     


Leu Tyr Leu Glu Gly Leu Thr Arg Pro Ile Leu Glu Gly Leu Tyr Gly 
            180                 185                 190         


Leu Ile Leu Glu Leu Glu Pro Arg Gly Leu Tyr Ser Glu Arg Ala Ser 
        195                 200                 205             


Pro Ser Glu Arg Thr His Arg Ala Ser Asn Thr Tyr Arg Ala Ser Asn 
    210                 215                 220                 


Gly Leu Leu Tyr Ser Pro His Glu Leu Tyr Ser Gly Leu Tyr His Ile 
225                 230                 235                 240 


Ser Val Ala Leu Thr His Arg Ile Leu Glu Ser Glu Arg Ala Leu Ala 
                245                 250                 255     


Ala Ser Pro Leu Tyr Ser Ser Glu Arg Ile Leu Glu Ser Glu Arg Thr 
            260                 265                 270         


His Arg Ala Leu Ala Thr Tyr Arg Leu Glu Gly Leu Asn Thr Arg Pro 
        275                 280                 285             


Ser Glu Arg Ser Glu Arg Leu Glu Leu Tyr Ser Ala Leu Ala Ser Glu 
    290                 295                 300                 


Arg Ala Ser Pro Thr His Arg Ala Leu Ala Val Ala Leu Thr Tyr Arg 
305                 310                 315                 320 


Thr Tyr Arg Cys Tyr Ser Ala Leu Ala Ala Arg Gly Ser Glu Arg Gly 
                325                 330                 335     


Leu Tyr Thr Tyr Arg Thr Tyr Arg Gly Leu Tyr Ser Glu Arg Ser Glu 
            340                 345                 350         


Arg Gly Leu Asn Thr Tyr Arg Thr Arg Pro Gly Leu Tyr Gly Leu Asn 
        355                 360                 365             


Gly Leu Tyr Thr His Arg Leu Glu Val Ala Leu Thr His Arg Val Ala 
    370                 375                 380                 


Leu Ser Glu Arg Ser Glu Arg 
385                 390     


<210>  8
<211>  391
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  Heavy Chain Variable Domain

<400>  8

Met Glu Thr Gly Leu Thr Arg Pro Ser Glu Arg Thr Arg Pro Val Ala 
1               5                   10                  15      


Leu Pro His Glu Leu Glu Pro His Glu Pro His Glu Leu Glu Ser Glu 
            20                  25                  30          


Arg Val Ala Leu Thr His Arg Thr His Arg Gly Leu Tyr Val Ala Leu 
        35                  40                  45              


His Ile Ser Ser Glu Arg Gly Leu Val Ala Leu Gly Leu Asn Leu Glu 
    50                  55                  60                  


Val Ala Leu Gly Leu Asn Ser Glu Arg Gly Leu Tyr Ala Leu Ala Gly 
65                  70                  75                  80  


Leu Val Ala Leu Leu Tyr Ser Leu Tyr Ser Pro Arg Gly Leu Tyr Gly 
                85                  90                  95      


Leu Ser Glu Arg Leu Glu Ala Arg Gly Ile Leu Glu Ser Glu Arg Cys 
            100                 105                 110         


Tyr Ser Leu Tyr Ser Gly Leu Tyr Ser Glu Arg Gly Leu Tyr Thr Tyr 
        115                 120                 125             


Arg Ser Glu Arg Pro His Glu Thr His Arg Ala Leu Ala Thr Tyr Arg 
    130                 135                 140                 


Thr Arg Pro Ile Leu Glu Gly Leu Thr Arg Pro Val Ala Leu Ala Arg 
145                 150                 155                 160 


Gly Gly Leu Asn Ala Leu Ala Pro Arg Gly Leu Tyr Leu Tyr Ser Gly 
                165                 170                 175     


Leu Tyr Leu Glu Gly Leu Thr Arg Pro Ile Leu Glu Gly Leu Tyr Gly 
            180                 185                 190         


Leu Ile Leu Glu Leu Glu Pro Arg Gly Leu Tyr Ser Glu Arg Ala Ser 
        195                 200                 205             


Pro Ser Glu Arg Thr His Arg Ala Ser Asn Thr Tyr Arg Ala Ser Asn 
    210                 215                 220                 


Gly Leu Leu Tyr Ser Pro His Glu Leu Tyr Ser Gly Leu Tyr His Ile 
225                 230                 235                 240 


Ser Val Ala Leu Thr His Arg Ile Leu Glu Ser Glu Arg Ala Leu Ala 
                245                 250                 255     


Ala Ser Pro Leu Tyr Ser Ser Glu Arg Ile Leu Glu Ser Glu Arg Thr 
            260                 265                 270         


His Arg Ala Leu Ala Thr Tyr Arg Leu Glu Gly Leu Asn Thr Arg Pro 
        275                 280                 285             


Ser Glu Arg Ser Glu Arg Leu Glu Leu Tyr Ser Ala Leu Ala Ser Glu 
    290                 295                 300                 


Arg Ala Ser Pro Thr His Arg Ala Leu Ala Val Ala Leu Thr Tyr Arg 
305                 310                 315                 320 


Thr Tyr Arg Cys Tyr Ser Ala Leu Ala Ala Arg Gly Ser Glu Arg Gly 
                325                 330                 335     


Leu Tyr Thr Tyr Arg Thr Tyr Arg Gly Leu Tyr Ser Glu Arg Ser Glu 
            340                 345                 350         


Arg Gly Leu Asn Thr Tyr Arg Thr Arg Pro Gly Leu Tyr Gly Leu Asn 
        355                 360                 365             


Gly Leu Tyr Thr His Arg Leu Glu Val Ala Leu Thr His Arg Val Ala 
    370                 375                 380                 


Leu Ser Glu Arg Ser Glu Arg 
385                 390     


<210>  9
<211>  365
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  Light Chain Variable Domain

<400>  9

Met Glu Thr Ser Glu Arg Val Ala Leu Pro Arg Thr His Arg Gly Leu 
1               5                   10                  15      


Asn Val Ala Leu Leu Glu Gly Leu Tyr Leu Glu Leu Glu Leu Glu Leu 
            20                  25                  30          


Glu Thr Arg Pro Leu Glu Thr His Arg Ala Ser Pro Ala Leu Ala Ala 
        35                  40                  45              


Arg Gly Cys Tyr Ser Ala Ser Pro Ile Leu Glu Val Ala Leu Leu Glu 
    50                  55                  60                  


Thr His Arg Gly Leu Asn Ser Glu Arg Pro Arg Ala Leu Ala Ser Glu 
65                  70                  75                  80  


Arg Leu Glu Ala Leu Ala Val Ala Leu Ser Glu Arg Pro Arg Gly Leu 
                85                  90                  95      


Tyr Gly Leu Asn Ala Arg Gly Ala Leu Ala Thr His Arg Ile Leu Glu 
            100                 105                 110         


Thr His Arg Cys Tyr Ser Ala Arg Gly Ala Leu Ala Ser Glu Arg Gly 
        115                 120                 125             


Leu Ser Glu Arg Val Ala Leu Ala Ser Pro Ser Glu Arg Thr Tyr Arg 
    130                 135                 140                 


Gly Leu Tyr Ala Ser Asn Ser Glu Arg Pro His Glu Met Glu Thr His 
145                 150                 155                 160 


Ile Ser Thr Arg Pro Thr Tyr Arg Gly Leu Asn Gly Leu Asn Leu Tyr 
                165                 170                 175     


Ser Pro Arg Gly Leu Tyr Gly Leu Asn Pro Arg Pro Arg Leu Tyr Ser 
            180                 185                 190         


Leu Glu Leu Glu Ile Leu Glu Thr Tyr Arg Leu Glu Thr His Arg Ser 
        195                 200                 205             


Glu Arg Ala Ser Asn Leu Glu Gly Leu Ser Glu Arg Gly Leu Tyr Val 
    210                 215                 220                 


Ala Leu Pro Arg Ala Ser Pro Ala Arg Gly Pro His Glu Ser Glu Arg 
225                 230                 235                 240 


Gly Leu Tyr Ser Glu Arg Gly Leu Tyr Ser Glu Arg Gly Leu Tyr Thr 
                245                 250                 255     


His Arg Ala Ser Pro Pro His Glu Thr His Arg Leu Glu Thr His Arg 
            260                 265                 270         


Ile Leu Glu Ala Ser Asn Pro Arg Val Ala Leu Gly Leu Ala Leu Ala 
        275                 280                 285             


Ala Ser Asn Ala Ser Pro Ala Leu Ala Ala Leu Ala Thr His Arg Thr 
    290                 295                 300                 


Tyr Arg Thr Tyr Arg Cys Tyr Ser Gly Leu Asn Gly Leu Asn Ala Ser 
305                 310                 315                 320 


Asn Ala Leu Ala Gly Leu Ala Ser Pro Pro Arg Ala Arg Gly Thr His 
                325                 330                 335     


Arg Pro His Glu Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Thr His Arg 
            340                 345                 350         


Leu Tyr Ser Leu Glu Gly Leu Ile Leu Glu Leu Tyr Ser 
        355                 360                 365 


<210>  10
<211>  365
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<223>  Light Chain Variable Domain

<400>  10

Met Glu Thr Ser Glu Arg Val Ala Leu Pro Arg Thr His Arg Gly Leu 
1               5                   10                  15      


Asn Val Ala Leu Leu Glu Gly Leu Tyr Leu Glu Leu Glu Leu Glu Leu 
            20                  25                  30          


Glu Thr Arg Pro Leu Glu Thr His Arg Ala Ser Pro Ala Leu Ala Ala 
        35                  40                  45              


Arg Gly Cys Tyr Ser Ala Ser Pro Ile Leu Glu Val Ala Leu Leu Glu 
    50                  55                  60                  


Thr His Arg Gly Leu Asn Ser Glu Arg Pro Arg Ala Leu Ala Ser Glu 
65                  70                  75                  80  


Arg Leu Glu Ala Leu Ala Val Ala Leu Ser Glu Arg Pro Arg Gly Leu 
                85                  90                  95      


Tyr Gly Leu Asn Ala Arg Gly Ala Leu Ala Thr His Arg Ile Leu Glu 
            100                 105                 110         


Thr His Arg Cys Tyr Ser Ala Arg Gly Ala Leu Ala Ser Glu Arg Gly 
        115                 120                 125             


Leu Ser Glu Arg Val Ala Leu Ala Ser Pro Ser Glu Arg Thr Tyr Arg 
    130                 135                 140                 


Gly Leu Tyr Ala Ser Asn Ser Glu Arg Pro His Glu Met Glu Thr His 
145                 150                 155                 160 


Ile Ser Thr Arg Pro Thr Tyr Arg Gly Leu Asn Gly Leu Asn Leu Tyr 
                165                 170                 175     


Ser Pro Arg Gly Leu Tyr Gly Leu Asn Pro Arg Pro Arg Leu Tyr Ser 
            180                 185                 190         


Leu Glu Leu Glu Ile Leu Glu Thr Tyr Arg Leu Glu Thr His Arg Ser 
        195                 200                 205             


Glu Arg Ala Ser Asn Leu Glu Gly Leu Ser Glu Arg Gly Leu Tyr Val 
    210                 215                 220                 


Ala Leu Pro Arg Ala Ser Pro Ala Arg Gly Pro His Glu Ser Glu Arg 
225                 230                 235                 240 


Gly Leu Tyr Ser Glu Arg Gly Leu Tyr Ser Glu Arg Gly Leu Tyr Thr 
                245                 250                 255     


His Arg Ala Ser Pro Pro His Glu Thr His Arg Leu Glu Thr His Arg 
            260                 265                 270         


Ile Leu Glu Ala Ser Asn Pro Arg Val Ala Leu Gly Leu Ala Leu Ala 
        275                 280                 285             


Ala Ser Asn Ala Ser Pro Ala Leu Ala Ala Leu Ala Thr His Arg Thr 
    290                 295                 300                 


Tyr Arg Thr Tyr Arg Cys Tyr Ser Gly Leu Asn Gly Leu Asn Ala Ser 
305                 310                 315                 320 


Asn Ala Leu Ala Gly Leu Ala Ser Pro Pro Arg Ala Arg Gly Thr His 
                325                 330                 335     


Arg Pro His Glu Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Thr His Arg 
            340                 345                 350         


Leu Tyr Ser Leu Glu Gly Leu Ile Leu Glu Leu Tyr Ser 
        355                 360                 365 


