                         SEQUENCE LISTING

<110>  Ruprecht-Karls-Universitt
 
<120>  ADENO-ASSOCIATED VIRUS (AAV) BASED REGULATORY SYSTEM

<130>  789-14 PCT

<150>  DE 10 2016 011 106.2
<151>  2016-09-14

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  34
<212>  DNA
<213>  Bacteriophage P1

<400>  1
ataacttcgt ataatgtatg ctatacgaag ttat                                   34


<210>  2
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxP derived variant lox site

<400>  2
ataacttcgt atagtataca ttatacgaag ttat                                   34


<210>  3
<211>  34
<212>  DNA
<213>  Bacteriophage C

<400>  3
acaacttcgt ataatgtatg ctatacgaag ttat                                   34


<210>  4
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxP derived variant lox site

<400>  4
ataacttcgt ataatatatg ctatacgaag ttat                                   34


<210>  5
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxP derived variant lox site

<400>  5
ataacttcgt atagcataca ttatacgaag ttat                                   34


<210>  6
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxP derived variant lox site

<400>  6
ataacttcgt ataatgtata ctatacgaag ttat                                   34


<210>  7
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ATAACTTCGTATAATATAAACTATACGAAGTTAT

<400>  7
ataacttcgt ataatatatg ctatacgaag ttat                                   34


<210>  8
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxP derived variant lox site

<400>  8
ataacttcgt ataatctaac ctatacgaag ttat                                   34


<210>  9
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxP derived variant lox site

<400>  9
ataacttcgt ataacatagc ctatacgaag ttat                                   34


<210>  10
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxP derived variant lox site

<400>  10
ataacttcgt ataacatacc ctatacgaag ttat                                   34


<210>  11
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxP derived variant lox site

<400>  11
attacctcgt atagcataca ttatacgaag ttat                                   34


<210>  12
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxP derived variant lox site

<400>  12
ataacttcgt atagcataca ttatatgaag ttat                                   34


<210>  13
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LoxP derived variant lox site

<400>  13
attacctcgt atagcataca ttatatgaag ttat                                   34


<210>  14
<211>  22
<212>  PRT
<213>  Porcine teschovirus-1

<400>  14

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  15
<211>  662
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRE recombinase linked to a mutant estrogen receptor allowing 
       regulation of recombinase activity

<400>  15

Met Asp Ile Ser Asn Leu Leu Thr Val His Gln Asn Leu Pro Ala Leu 
1               5                   10                  15      


Pro Val Asp Ala Thr Ser Asp Glu Val Arg Lys Asn Leu Met Asp Met 
            20                  25                  30          


Phe Arg Asp Arg Gln Ala Phe Ser Glu His Thr Trp Lys Met Leu Leu 
        35                  40                  45              


Ser Val Cys Arg Ser Trp Ala Ala Trp Cys Lys Leu Asn Asn Arg Lys 
    50                  55                  60                  


Trp Phe Pro Ala Glu Pro Glu Asp Val Arg Asp Tyr Leu Leu Tyr Leu 
65                  70                  75                  80  


Gln Ala Arg Gly Leu Ala Val Lys Thr Ile Gln Gln His Leu Gly Gln 
                85                  90                  95      


Leu Asn Met Leu His Arg Arg Ser Gly Leu Pro Arg Pro Ser Asp Ser 
            100                 105                 110         


Asn Ala Val Ser Leu Val Met Arg Arg Ile Arg Lys Glu Asn Val Asp 
        115                 120                 125             


Ala Gly Glu Arg Ala Lys Gln Ala Leu Ala Phe Glu Arg Thr Asp Phe 
    130                 135                 140                 


Asp Gln Val Arg Ser Leu Met Glu Asn Ser Asp Arg Cys Gln Asp Ile 
145                 150                 155                 160 


Arg Asn Leu Ala Phe Leu Gly Ile Ala Tyr Asn Thr Leu Leu Arg Ile 
                165                 170                 175     


Ala Glu Ile Ala Arg Ile Arg Val Lys Asp Ile Ser Arg Thr Asp Gly 
            180                 185                 190         


Gly Arg Met Leu Ile His Ile Gly Arg Thr Lys Thr Leu Val Ser Thr 
        195                 200                 205             


Ala Gly Val Glu Lys Ala Leu Ser Leu Gly Val Thr Lys Leu Val Glu 
    210                 215                 220                 


Arg Trp Ile Ser Val Ser Gly Val Ala Asp Asp Pro Asn Asn Tyr Leu 
225                 230                 235                 240 


Phe Cys Arg Val Arg Lys Asn Gly Val Ala Ala Pro Ser Ala Thr Ser 
                245                 250                 255     


Gln Leu Ser Thr Arg Ala Leu Glu Gly Ile Phe Glu Ala Thr His Arg 
            260                 265                 270         


Leu Ile Tyr Gly Ala Lys Asp Asp Ser Gly Gln Arg Tyr Leu Ala Trp 
        275                 280                 285             


Ser Gly His Ser Ala Arg Val Gly Ala Ala Arg Asp Met Ala Arg Ala 
    290                 295                 300                 


Gly Val Ser Ile Pro Glu Ile Met Gln Ala Gly Gly Trp Thr Asn Val 
305                 310                 315                 320 


Asn Ile Val Met Asn Tyr Ile Arg Asn Leu Asp Ser Glu Thr Gly Ala 
                325                 330                 335     


Met Val Arg Leu Leu Glu Asp Gly Asp Leu Glu Pro Ser Ala Gly Asp 
            340                 345                 350         


Met Arg Ala Ala Asn Leu Trp Pro Ser Pro Leu Met Ile Lys Arg Ser 
        355                 360                 365             


Lys Lys Asn Ser Leu Ala Leu Ser Leu Thr Ala Asp Gln Met Val Ser 
    370                 375                 380                 


Ala Leu Leu Asp Ala Glu Pro Pro Ile Leu Tyr Ser Glu Tyr Asp Pro 
385                 390                 395                 400 


Thr Arg Pro Phe Ser Glu Ala Ser Met Met Gly Leu Leu Thr Asn Leu 
                405                 410                 415     


Ala Asp Arg Glu Leu Val His Met Ile Asn Trp Ala Lys Arg Val Pro 
            420                 425                 430         


Gly Phe Val Asp Leu Thr Leu His Asp Gln Val His Leu Leu Glu Cys 
        435                 440                 445             


Ala Trp Leu Glu Ile Leu Met Ile Gly Leu Val Trp Arg Ser Met Glu 
    450                 455                 460                 


His Pro Val Lys Leu Leu Phe Ala Pro Asn Leu Leu Leu Asp Arg Asn 
465                 470                 475                 480 


Gln Gly Lys Cys Val Glu Gly Met Val Glu Ile Phe Asp Met Leu Leu 
                485                 490                 495     


Ala Thr Ser Ser Arg Phe Arg Met Met Asn Leu Gln Gly Glu Glu Phe 
            500                 505                 510         


Val Cys Leu Lys Ser Ile Ile Leu Leu Asn Ser Gly Val Tyr Thr Phe 
        515                 520                 525             


Leu Ser Ser Thr Leu Lys Ser Leu Glu Glu Lys Asp His Ile His Arg 
    530                 535                 540                 


Val Leu Asp Lys Ile Thr Asp Thr Leu Ile His Leu Met Ala Lys Ala 
545                 550                 555                 560 


Gly Leu Thr Leu Gln Gln Gln His Gln Arg Leu Ala Gln Leu Leu Leu 
                565                 570                 575     


Ile Leu Ser His Ile Arg His Met Ser Asn Lys Gly Met Glu His Leu 
            580                 585                 590         


Tyr Ser Met Lys Cys Lys Asn Val Val Pro Leu Tyr Asp Leu Leu Leu 
        595                 600                 605             


Glu Ala Ala Asp Ala His Arg Leu His Ala Pro Thr Ser Arg Gly Gly 
    610                 615                 620                 


Ala Ser Val Glu Glu Thr Asp Gln Ser His Leu Ala Thr Ala Gly Ser 
625                 630                 635                 640 


Thr Ser Ser His Ser Leu Gln Lys Tyr Tyr Ile Thr Gly Glu Ala Glu 
                645                 650                 655     


Gly Phe Pro Ala Thr Val 
            660         


<210>  16
<211>  635
<212>  DNA
<213>  Cytomegaly virus

<400>  16
ttaatagtaa tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac       60

ataacttacg gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc      120

aataatgacg tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt      180

ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc      240

gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac      300

cttacgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt      360

gatgcggttt tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc      420

aagtctccac cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt      480

tccaaaatgt cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg      540

ggaggtctat ataagcagag ctcgtttagt gaaccgtcag atcactagaa gctttattgc      600

ggtagtttat cacagttaaa ttgctaacgc agtca                                 635


<210>  17
<211>  144
<212>  DNA
<213>  adeno-associated virus

<400>  17
tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc       60

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga gagggagtgg      120

ccaactccat cactaggggt tcct                                             144


<210>  18
<211>  311
<212>  PRT
<213>  Renilla reniformis

<400>  18

Met Ala Ser Lys Val Tyr Asp Pro Glu Gln Arg Lys Arg Met Ile Thr 
1               5                   10                  15      


Gly Pro Gln Trp Trp Ala Arg Cys Lys Gln Met Asn Val Leu Asp Ser 
            20                  25                  30          


Phe Ile Asn Tyr Tyr Asp Ser Glu Lys His Ala Glu Asn Ala Val Ile 
        35                  40                  45              


Phe Leu His Gly Asn Ala Ala Ser Ser Tyr Leu Trp Arg His Val Val 
    50                  55                  60                  


Pro His Ile Glu Pro Val Ala Arg Cys Ile Ile Pro Asp Leu Ile Gly 
65                  70                  75                  80  


Met Gly Lys Ser Gly Lys Ser Gly Asn Gly Ser Tyr Arg Leu Leu Asp 
                85                  90                  95      


His Tyr Lys Tyr Leu Thr Ala Trp Phe Glu Leu Leu Asn Leu Pro Lys 
            100                 105                 110         


Lys Ile Ile Phe Val Gly His Asp Trp Gly Ala Cys Leu Ala Phe His 
        115                 120                 125             


Tyr Ser Tyr Glu His Gln Asp Lys Ile Lys Ala Ile Val His Ala Glu 
    130                 135                 140                 


Ser Val Val Asp Val Ile Glu Ser Trp Asp Glu Trp Pro Asp Ile Glu 
145                 150                 155                 160 


Glu Asp Ile Ala Leu Ile Lys Ser Glu Glu Gly Glu Lys Met Val Leu 
                165                 170                 175     


Glu Asn Asn Phe Phe Val Glu Thr Met Leu Pro Ser Lys Ile Met Arg 
            180                 185                 190         


Lys Leu Glu Pro Glu Glu Phe Ala Ala Tyr Leu Glu Pro Phe Lys Glu 
        195                 200                 205             


Lys Gly Glu Val Arg Arg Pro Thr Leu Ser Trp Pro Arg Glu Ile Pro 
    210                 215                 220                 


Leu Val Lys Gly Gly Lys Pro Asp Val Val Gln Ile Val Arg Asn Tyr 
225                 230                 235                 240 


Asn Ala Tyr Leu Arg Ala Ser Asp Asp Leu Pro Lys Met Phe Ile Glu 
                245                 250                 255     


Ser Asp Pro Gly Phe Phe Ser Asn Ala Ile Val Glu Gly Ala Lys Lys 
            260                 265                 270         


Phe Pro Asn Thr Glu Phe Val Lys Val Lys Gly Leu His Phe Ser Gln 
        275                 280                 285             


Glu Asp Ala Pro Asp Glu Met Gly Lys Tyr Ile Lys Ser Phe Val Glu 
    290                 295                 300                 


Arg Val Leu Lys Asn Glu Gln 
305                 310     


<210>  19
<211>  4430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV vector according to the first aspect of the invention with an
       arrangement of elements according to alternative (a)

<400>  19
tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc       60

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga gagggagtgg      120

ccaactccat cactaggggt tccttgtagt taatgattaa cccgccatgc tacttatcta      180

cgtagccatg ctctagagca agatcgaatt caattcttcg aaggcgcgat aacttcgtat      240

agcatacatt atacgaagtt atggcgcgcc ttaatagtaa tcaattacgg ggtcattagt      300

tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg      360

accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc      420

aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc      480

agtacatcaa gtgtatcata tgccaagtcc gccccctatt gacgtcaatg acggtaaatg      540

gcccgcctgg cattatgccc agtacatgac cttacgggac tttcctactt ggcagtacat      600

ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca ccaatgggcg      660

tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag      720

tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaataacc ccgccccgtt      780

gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctcgtttagt      840

gaaccgtcag atcactagaa gctttattgc ggtagtttat cacagttaaa ttgctaacgc      900

agtcacttaa gataacttcg tatagcatac attatacgaa gttatatgca tttaaggcca      960

ccatggcttc caaggtgtac gaccccgagc aacgcaaacg catgatcact gggcctcagt     1020

ggtgggctcg ctgcaagcaa atgaacgtgc tggactcctt catcaactac tatgattccg     1080

agaagcacgc cgagaacgcc gtgatttttc tgcatggtaa cgctgcctcc agctacctgt     1140

ggaggcacgt cgtgcctcac atcgagcccg tggctagatg catcatccct gatctgatcg     1200

gaatgggtaa gtccggcaag agcgggaatg gctcatatcg cctcctggat cactacaagt     1260

acctcaccgc ttggttcgag ctgctgaacc ttccaaagaa aatcatcttt gtgggccacg     1320

actggggggc ttgtctggcc tttcactact cctacgagca ccaagacaag atcaaggcca     1380

tcgtccatgc tgagagtgtc gtggacgtga tcgagtcctg ggacgagtgg cctgacatcg     1440

aggaggatat cgccctgatc aagagcgaag agggcgagaa aatggtgctt gagaataact     1500

tcttcgtcga gaccatgctc ccaagcaaga tcatgcggaa actggagcct gaggagttcg     1560

ctgcctacct ggagccattc aaggagaagg gcgaggttag acggcctacc ctctcctggc     1620

ctcgcgagat ccctctcgtt aagggaggca agcccgacgt cgtccagatt gtccgcaact     1680

acaacgccta ccttcgggcc agcgacgatc tgcctaagat gttcatcgag tccgaccctg     1740

ggttcttttc caacgctatt gtcgagggag ctaagaagtt ccctaacacc gagttcgtga     1800

aggtgaaggg cctccacttc agccaggagg acgctccaga tgaaatgggt aagtacatca     1860

agagcttcgt ggagcgcgtg ctgaagaacg agcagggcgc caccggtgga agcggagcta     1920

ctaacttcag cctgctgaag caggctggag acgtggagga gaaccctgga cctatggata     1980

tctccaacct gctgactgtg caccaaaacc tgcctgccct ccctgtggat gccacctctg     2040

atgaagtcag gaagaacctg atggacatgt tcagggacag gcaggccttc tctgaacaca     2100

cctggaagat gctcctgtct gtgtgcagat cctgggctgc ctggtgcaag ctgaacaaca     2160

ggaaatggtt ccctgctgaa cctgaggatg tgagggacta cctcctgtac ctgcaagcca     2220

gaggcctggc tgtgaagacc atccaacagc acctgggcca gctcaacatg ctgcacagga     2280

gatctggcct gcctcgccct tctgactcca atgctgtgtc cctggtgatg aggagaatca     2340

gaaaggagaa tgtggatgct ggggagagag ccaagcaggc cctggccttt gaacgcactg     2400

actttgacca agtcagatcc ctgatggaga actctgacag atgccaggac atcaggaacc     2460

tggccttcct gggcattgcc tacaacaccc tgctgcgcat tgccgaaatt gccagaatca     2520

gagtgaagga catctcccgc accgatggtg ggagaatgct gatccacatt ggcaggacca     2580

agaccctggt gtccacagct ggtgtggaga aggccctgtc cctgggggtt accaagctgg     2640

tggagagatg gatctctgtg tctggtgtgg ctgatgaccc caacaactac ctgttctgcc     2700

gggtcagaaa gaatggtgtg gctgcccctt ctgccacctc ccaactgtcc acccgggccc     2760

tggaagggat ctttgaggcc acccaccgcc tgatctatgg tgccaaggat gactctgggc     2820

agagatacct ggcctggtct ggccactctg ccagagtggg tgctgccagg gacatggcca     2880

gggctggtgt gtccatccct gaaatcatgc aggctggtgg ctggaccaat gtgaacattg     2940

tgatgaacta catcagaaac ctggactctg agactggggc catggtgagg ctgctcgaag     3000

atggcgatct cgagccatct gctggagaca tgagagctgc caacctttgg ccaagcccgc     3060

tcatgatcaa acgctctaag aagaacagcc tggccttgtc cctgacggcc gaccagatgg     3120

tcagtgcctt gttggatgct gagcccccca tactctattc cgagtatgat cctaccagac     3180

ccttcagtga agcttcgatg atgggcttac tgaccaacct ggcagacagg gagctggttc     3240

acatgatcaa ctgggcgaag agggtgccag gctttgtgga tttgaccctc catgatcagg     3300

tccaccttct agaatgtgcc tggctagaga tcctgatgat tggtctcgtc tggcgctcca     3360

tggagcaccc agtgaagcta ctgtttgctc ctaacttgct cttggacagg aaccagggaa     3420

aatgtgtaga gggcatggtg gagatcttcg acatgctgct ggctacatca tctcggttcc     3480

gcatgatgaa tctgcaggga gaggagtttg tgtgcctcaa atctattatt ttgcttaatt     3540

ctggagtgta cacatttctg tccagcaccc tgaagtctct ggaagagaag gaccatatcc     3600

accgagtcct ggacaagatc acagacactt tgatccacct gatggccaag gcaggcctga     3660

ccctgcagca gcagcaccag cggctggccc agctcctcct catcctctcc cacatcaggc     3720

acatgagtaa caaaggcatg gagcatctgt acagcatgaa gtgcaagaac gtggtgcccc     3780

tctatgacct gctgctggag gcggcggacg cccaccgcct acatgcgccc actagccgtg     3840

gaggggcatc cgtggaggag acggaccaaa gccacttggc cactgcgggc tctacttcat     3900

cgcattcctt gcaaaagtat tacatcacgg gggaggcaga gggtttccct gccacagtct     3960

gagaggatcc cagacatgat aagatacatt gatgagtttg gacaaaccac aactagaatg     4020

cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt     4080

ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag     4140

ggggaggtgt gggaggtttt ttaaagcatc gttatcgatg ctagcctagt aataaaccgg     4200

acattcgaaa ggctgcggtc gaactctagt tgctctagag catggctacg tagataagta     4260

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     4320

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt     4380

tgcccgggcg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca                4430


<210>  20
<211>  4444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV vector according to the first aspect of the invention with an
       arrangement of elements according to alternative (b)

<400>  20
tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc       60

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga gagggagtgg      120

ccaactccat cactaggggt tccttgtagt taatgattaa cccgccatgc tacttatcta      180

cgtagccatg ctctagagca agatcgaatt caattcttcg aaggcgcgcc ttaatagtaa      240

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      300

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      360

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      420

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc gccccctatt      480

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttacgggac      540

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      600

tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      660

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      720

cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      780

ataagcagag ctcgtttagt gaaccgtcag atcactagaa gctttattgc ggtagtttat      840

cacagttaaa ttgctaacgc agtcacttaa gataacttcg tatagcatac attatacgaa      900

gttatatgca tttaaggcca ccatggcttc caaggtgtac gaccccgagc aacgcaaacg      960

catgatcact gggcctcagt ggtgggctcg ctgcaagcaa atgaacgtgc tggactcctt     1020

catcaactac tatgattccg agaagcacgc cgagaacgcc gtgatttttc tgcatggtaa     1080

cgctgcctcc agctacctgt ggaggcacgt cgtgcctcac atcgagcccg tggctagatg     1140

catcatccct gatctgatcg gaatgggtaa gtccggcaag agcgggaatg gctcatatcg     1200

cctcctggat cactacaagt acctcaccgc ttggttcgag ctgctgaacc ttccaaagaa     1260

aatcatcttt gtgggccacg actggggggc ttgtctggcc tttcactact cctacgagca     1320

ccaagacaag atcaaggcca tcgtccatgc tgagagtgtc gtggacgtga tcgagtcctg     1380

ggacgagtgg cctgacatcg aggaggatat cgccctgatc aagagcgaag agggcgagaa     1440

aatggtgctt gagaataact tcttcgtcga gaccatgctc ccaagcaaga tcatgcggaa     1500

actggagcct gaggagttcg ctgcctacct ggagccattc aaggagaagg gcgaggttag     1560

acggcctacc ctctcctggc ctcgcgagat ccctctcgtt aagggaggca agcccgacgt     1620

cgtccagatt gtccgcaact acaacgccta ccttcgggcc agcgacgatc tgcctaagat     1680

gttcatcgag tccgaccctg ggttcttttc caacgctatt gtcgagggag ctaagaagtt     1740

ccctaacacc gagttcgtga aggtgaaggg cctccacttc agccaggagg acgctccaga     1800

tgaaatgggt aagtacatca agagcttcgt ggagcgcgtg ctgaagaacg agcagggcgc     1860

caccggtata acttcgtata gcatacatta tacgaagtta tgtttaaact ccggtggaag     1920

cggagctact aacttcagcc tgctgaagca ggctggagac gtggaggaga accctggacc     1980

tatggatatc tccaacctgc tgactgtgca ccaaaacctg cctgccctcc ctgtggatgc     2040

cacctctgat gaagtcagga agaacctgat ggacatgttc agggacaggc aggccttctc     2100

tgaacacacc tggaagatgc tcctgtctgt gtgcagatcc tgggctgcct ggtgcaagct     2160

gaacaacagg aaatggttcc ctgctgaacc tgaggatgtg agggactacc tcctgtacct     2220

gcaagccaga ggcctggctg tgaagaccat ccaacagcac ctgggccagc tcaacatgct     2280

gcacaggaga tctggcctgc ctcgcccttc tgactccaat gctgtgtccc tggtgatgag     2340

gagaatcaga aaggagaatg tggatgctgg ggagagagcc aagcaggccc tggcctttga     2400

acgcactgac tttgaccaag tcagatccct gatggagaac tctgacagat gccaggacat     2460

caggaacctg gccttcctgg gcattgccta caacaccctg ctgcgcattg ccgaaattgc     2520

cagaatcaga gtgaaggaca tctcccgcac cgatggtggg agaatgctga tccacattgg     2580

caggaccaag accctggtgt ccacagctgg tgtggagaag gccctgtccc tgggggttac     2640

caagctggtg gagagatgga tctctgtgtc tggtgtggct gatgacccca acaactacct     2700

gttctgccgg gtcagaaaga atggtgtggc tgccccttct gccacctccc aactgtccac     2760

ccgggccctg gaagggatct ttgaggccac ccaccgcctg atctatggtg ccaaggatga     2820

ctctgggcag agatacctgg cctggtctgg ccactctgcc agagtgggtg ctgccaggga     2880

catggccagg gctggtgtgt ccatccctga aatcatgcag gctggtggct ggaccaatgt     2940

gaacattgtg atgaactaca tcagaaacct ggactctgag actggggcca tggtgaggct     3000

gctcgaagat ggcgatctcg agccatctgc tggagacatg agagctgcca acctttggcc     3060

aagcccgctc atgatcaaac gctctaagaa gaacagcctg gccttgtccc tgacggccga     3120

ccagatggtc agtgccttgt tggatgctga gccccccata ctctattccg agtatgatcc     3180

taccagaccc ttcagtgaag cttcgatgat gggcttactg accaacctgg cagacaggga     3240

gctggttcac atgatcaact gggcgaagag ggtgccaggc tttgtggatt tgaccctcca     3300

tgatcaggtc caccttctag aatgtgcctg gctagagatc ctgatgattg gtctcgtctg     3360

gcgctccatg gagcacccag tgaagctact gtttgctcct aacttgctct tggacaggaa     3420

ccagggaaaa tgtgtagagg gcatggtgga gatcttcgac atgctgctgg ctacatcatc     3480

tcggttccgc atgatgaatc tgcagggaga ggagtttgtg tgcctcaaat ctattatttt     3540

gcttaattct ggagtgtaca catttctgtc cagcaccctg aagtctctgg aagagaagga     3600

ccatatccac cgagtcctgg acaagatcac agacactttg atccacctga tggccaaggc     3660

aggcctgacc ctgcagcagc agcaccagcg gctggcccag ctcctcctca tcctctccca     3720

catcaggcac atgagtaaca aaggcatgga gcatctgtac agcatgaagt gcaagaacgt     3780

ggtgcccctc tatgacctgc tgctggaggc ggcggacgcc caccgcctac atgcgcccac     3840

tagccgtgga ggggcatccg tggaggagac ggaccaaagc cacttggcca ctgcgggctc     3900

tacttcatcg cattccttgc aaaagtatta catcacgggg gaggcagagg gtttccctgc     3960

cacagtctga gaggatccag atcccagaca tgataagata cattgatgag tttggacaaa     4020

ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt     4080

tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta     4140

tgtttcaggt tcagggggag gtgtgggagg ttttttaaag catcgttatc gatgctagcc     4200

tagtaataaa ccggacattc gaaaggctgc ggtcgaactc tagttgctct agagcatggc     4260

tacgtagata agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag     4320

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     4380

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg     4440

gcca                                                                  4444


<210>  21
<211>  4433
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV vector according to the first aspect of the invention with an
       arrangement of elements according to alternative (c)

<400>  21
tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc       60

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga gagggagtgg      120

ccaactccat cactaggggt tccttgtagt taatgattaa cccgccatgc tacttatcta      180

cgtagccatg ctctagagca agatcgaatt caattcttcg aaggcgcgat aacttcgtat      240

agcatacatt atacgaagtt atggcgcgcc ttaatagtaa tcaattacgg ggtcattagt      300

tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg      360

accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc      420

aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc      480

agtacatcaa gtgtatcata tgccaagtcc gccccctatt gacgtcaatg acggtaaatg      540

gcccgcctgg cattatgccc agtacatgac cttacgggac tttcctactt ggcagtacat      600

ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca ccaatgggcg      660

tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag      720

tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaataacc ccgccccgtt      780

gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctcgtttagt      840

gaaccgtcag atcactagaa gctttattgc ggtagtttat cacagttaaa ttgctaacgc      900

agtcacttaa ggccaccatg gcttccaagg tgtacgaccc cgagcaacgc aaacgcatga      960

tcactgggcc tcagtggtgg gctcgctgca agcaaatgaa cgtgctggac tccttcatca     1020

actactatga ttccgagaag cacgccgaga acgccgtgat ttttctgcat ggtaacgctg     1080

cctccagcta cctgtggagg cacgtcgtgc ctcacatcga gcccgtggct agatgcatca     1140

tccctgatct gatcggaatg ggtaagtccg gcaagagcgg gaatggctca tatcgcctcc     1200

tggatcacta caagtacctc accgcttggt tcgagctgct gaaccttcca aagaaaatca     1260

tctttgtggg ccacgactgg ggggcttgtc tggcctttca ctactcctac gagcaccaag     1320

acaagatcaa ggccatcgtc catgctgaga gtgtcgtgga cgtgatcgag tcctgggacg     1380

agtggcctga catcgaggag gatatcgccc tgatcaagag cgaagagggc gagaaaatgg     1440

tgcttgagaa taacttcttc gtcgagacca tgctcccaag caagatcatg cggaaactgg     1500

agcctgagga gttcgctgcc tacctggagc cattcaagga gaagggcgag gttagacggc     1560

ctaccctctc ctggcctcgc gagatccctc tcgttaaggg aggcaagccc gacgtcgtcc     1620

agattgtccg caactacaac gcctaccttc gggccagcga cgatctgcct aagatgttca     1680

tcgagtccga ccctgggttc ttttccaacg ctattgtcga gggagctaag aagttcccta     1740

acaccgagtt cgtgaaggtg aagggcctcc acttcagcca ggaggacgct ccagatgaaa     1800

tgggtaagta catcaagagc ttcgtggagc gcgtgctgaa gaacgagcag ggcgccaccg     1860

gtataacttc gtatagcata cattatacga agttatgttt aaactccggt ggaagcggag     1920

ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct ggacctatgg     1980

atatctccaa cctgctgact gtgcaccaaa acctgcctgc cctccctgtg gatgccacct     2040

ctgatgaagt caggaagaac ctgatggaca tgttcaggga caggcaggcc ttctctgaac     2100

acacctggaa gatgctcctg tctgtgtgca gatcctgggc tgcctggtgc aagctgaaca     2160

acaggaaatg gttccctgct gaacctgagg atgtgaggga ctacctcctg tacctgcaag     2220

ccagaggcct ggctgtgaag accatccaac agcacctggg ccagctcaac atgctgcaca     2280

ggagatctgg cctgcctcgc ccttctgact ccaatgctgt gtccctggtg atgaggagaa     2340

tcagaaagga gaatgtggat gctggggaga gagccaagca ggccctggcc tttgaacgca     2400

ctgactttga ccaagtcaga tccctgatgg agaactctga cagatgccag gacatcagga     2460

acctggcctt cctgggcatt gcctacaaca ccctgctgcg cattgccgaa attgccagaa     2520

tcagagtgaa ggacatctcc cgcaccgatg gtgggagaat gctgatccac attggcagga     2580

ccaagaccct ggtgtccaca gctggtgtgg agaaggccct gtccctgggg gttaccaagc     2640

tggtggagag atggatctct gtgtctggtg tggctgatga ccccaacaac tacctgttct     2700

gccgggtcag aaagaatggt gtggctgccc cttctgccac ctcccaactg tccacccggg     2760

ccctggaagg gatctttgag gccacccacc gcctgatcta tggtgccaag gatgactctg     2820

ggcagagata cctggcctgg tctggccact ctgccagagt gggtgctgcc agggacatgg     2880

ccagggctgg tgtgtccatc cctgaaatca tgcaggctgg tggctggacc aatgtgaaca     2940

ttgtgatgaa ctacatcaga aacctggact ctgagactgg ggccatggtg aggctgctcg     3000

aagatggcga tctcgagcca tctgctggag acatgagagc tgccaacctt tggccaagcc     3060

cgctcatgat caaacgctct aagaagaaca gcctggcctt gtccctgacg gccgaccaga     3120

tggtcagtgc cttgttggat gctgagcccc ccatactcta ttccgagtat gatcctacca     3180

gacccttcag tgaagcttcg atgatgggct tactgaccaa cctggcagac agggagctgg     3240

ttcacatgat caactgggcg aagagggtgc caggctttgt ggatttgacc ctccatgatc     3300

aggtccacct tctagaatgt gcctggctag agatcctgat gattggtctc gtctggcgct     3360

ccatggagca cccagtgaag ctactgtttg ctcctaactt gctcttggac aggaaccagg     3420

gaaaatgtgt agagggcatg gtggagatct tcgacatgct gctggctaca tcatctcggt     3480

tccgcatgat gaatctgcag ggagaggagt ttgtgtgcct caaatctatt attttgctta     3540

attctggagt gtacacattt ctgtccagca ccctgaagtc tctggaagag aaggaccata     3600

tccaccgagt cctggacaag atcacagaca ctttgatcca cctgatggcc aaggcaggcc     3660

tgaccctgca gcagcagcac cagcggctgg cccagctcct cctcatcctc tcccacatca     3720

ggcacatgag taacaaaggc atggagcatc tgtacagcat gaagtgcaag aacgtggtgc     3780

ccctctatga cctgctgctg gaggcggcgg acgcccaccg cctacatgcg cccactagcc     3840

gtggaggggc atccgtggag gagacggacc aaagccactt ggccactgcg ggctctactt     3900

catcgcattc cttgcaaaag tattacatca cgggggaggc agagggtttc cctgccacag     3960

tctgagagga tcccagacat gataagatac attgatgagt ttggacaaac cacaactaga     4020

atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc     4080

attataagct gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt     4140

cagggggagg tgtgggaggt tttttaaagc atcgttatcg atgctagcct agtaataaac     4200

cggacattcg aaaggctgcg gtcgaactct agttgctcta gagcatggct acgtagataa     4260

gtagcatggc gggttaatca ttaactacaa ggaaccccta gtgatggagt tggccactcc     4320

ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg     4380

ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga gagggagtgg cca            4433


<210>  22
<211>  4436
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV vector according to the first aspect of the invention with an
       arrangement of elements according to alternative (e)

<400>  22
tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc       60

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga gagggagtgg      120

ccaactccat cactaggggt tccttgtagt taatgattaa cccgccatgc tacttatcta      180

cgtagccatg ctctagagca agatcgaatt caattcttcg aaggcgcgcc ttaatagtaa      240

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      300

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      360

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      420

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc gccccctatt      480

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttacgggac      540

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      600

tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      660

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      720

cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      780

ataagcagag ctcgtttagt gaaccgtcag atcactagaa gctttattgc ggtagtttat      840

cacagttaaa ttgctaacgc agtcacttaa gataacttcg tatagcatac attatacgaa      900

gttatatgca tttaaggcca ccatggcttc caaggtgtac gaccccgagc aacgcaaacg      960

catgatcact gggcctcagt ggtgggctcg ctgcaagcaa atgaacgtgc tggactcctt     1020

catcaactac tatgattccg agaagcacgc cgagaacgcc gtgatttttc tgcatggtaa     1080

cgctgcctcc agctacctgt ggaggcacgt cgtgcctcac atcgagcccg tggctagatg     1140

catcatccct gatctgatcg gaatgggtaa gtccggcaag agcgggaatg gctcatatcg     1200

cctcctggat cactacaagt acctcaccgc ttggttcgag ctgctgaacc ttccaaagaa     1260

aatcatcttt gtgggccacg actggggggc ttgtctggcc tttcactact cctacgagca     1320

ccaagacaag atcaaggcca tcgtccatgc tgagagtgtc gtggacgtga tcgagtcctg     1380

ggacgagtgg cctgacatcg aggaggatat cgccctgatc aagagcgaag agggcgagaa     1440

aatggtgctt gagaataact tcttcgtcga gaccatgctc ccaagcaaga tcatgcggaa     1500

actggagcct gaggagttcg ctgcctacct ggagccattc aaggagaagg gcgaggttag     1560

acggcctacc ctctcctggc ctcgcgagat ccctctcgtt aagggaggca agcccgacgt     1620

cgtccagatt gtccgcaact acaacgccta ccttcgggcc agcgacgatc tgcctaagat     1680

gttcatcgag tccgaccctg ggttcttttc caacgctatt gtcgagggag ctaagaagtt     1740

ccctaacacc gagttcgtga aggtgaaggg cctccacttc agccaggagg acgctccaga     1800

tgaaatgggt aagtacatca agagcttcgt ggagcgcgtg ctgaagaacg agcagggcgc     1860

caccggtgga agcggagcta ctaacttcag cctgctgaag caggctggag acgtggagga     1920

gaaccctgga cctatggata tctccaacct gctgactgtg caccaaaacc tgcctgccct     1980

ccctgtggat gccacctctg atgaagtcag gaagaacctg atggacatgt tcagggacag     2040

gcaggccttc tctgaacaca cctggaagat gctcctgtct gtgtgcagat cctgggctgc     2100

ctggtgcaag ctgaacaaca ggaaatggtt ccctgctgaa cctgaggatg tgagggacta     2160

cctcctgtac ctgcaagcca gaggcctggc tgtgaagacc atccaacagc acctgggcca     2220

gctcaacatg ctgcacagga gatctggcct gcctcgccct tctgactcca atgctgtgtc     2280

cctggtgatg aggagaatca gaaaggagaa tgtggatgct ggggagagag ccaagcaggc     2340

cctggccttt gaacgcactg actttgacca agtcagatcc ctgatggaga actctgacag     2400

atgccaggac atcaggaacc tggccttcct gggcattgcc tacaacaccc tgctgcgcat     2460

tgccgaaatt gccagaatca gagtgaagga catctcccgc accgatggtg ggagaatgct     2520

gatccacatt ggcaggacca agaccctggt gtccacagct ggtgtggaga aggccctgtc     2580

cctgggggtt accaagctgg tggagagatg gatctctgtg tctggtgtgg ctgatgaccc     2640

caacaactac ctgttctgcc gggtcagaaa gaatggtgtg gctgcccctt ctgccacctc     2700

ccaactgtcc acccgggccc tggaagggat ctttgaggcc acccaccgcc tgatctatgg     2760

tgccaaggat gactctgggc agagatacct ggcctggtct ggccactctg ccagagtggg     2820

tgctgccagg gacatggcca gggctggtgt gtccatccct gaaatcatgc aggctggtgg     2880

ctggaccaat gtgaacattg tgatgaacta catcagaaac ctggactctg agactggggc     2940

catggtgagg ctgctcgaag atggcgatct cgagccatct gctggagaca tgagagctgc     3000

caacctttgg ccaagcccgc tcatgatcaa acgctctaag aagaacagcc tggccttgtc     3060

cctgacggcc gaccagatgg tcagtgcctt gttggatgct gagcccccca tactctattc     3120

cgagtatgat cctaccagac ccttcagtga agcttcgatg atgggcttac tgaccaacct     3180

ggcagacagg gagctggttc acatgatcaa ctgggcgaag agggtgccag gctttgtgga     3240

tttgaccctc catgatcagg tccaccttct agaatgtgcc tggctagaga tcctgatgat     3300

tggtctcgtc tggcgctcca tggagcaccc agtgaagcta ctgtttgctc ctaacttgct     3360

cttggacagg aaccagggaa aatgtgtaga gggcatggtg gagatcttcg acatgctgct     3420

ggctacatca tctcggttcc gcatgatgaa tctgcaggga gaggagtttg tgtgcctcaa     3480

atctattatt ttgcttaatt ctggagtgta cacatttctg tccagcaccc tgaagtctct     3540

ggaagagaag gaccatatcc accgagtcct ggacaagatc acagacactt tgatccacct     3600

gatggccaag gcaggcctga ccctgcagca gcagcaccag cggctggccc agctcctcct     3660

catcctctcc cacatcaggc acatgagtaa caaaggcatg gagcatctgt acagcatgaa     3720

gtgcaagaac gtggtgcccc tctatgacct gctgctggag gcggcggacg cccaccgcct     3780

acatgcgccc actagccgtg gaggggcatc cgtggaggag acggaccaaa gccacttggc     3840

cactgcgggc tctacttcat cgcattcctt gcaaaagtat tacatcacgg gggaggcaga     3900

gggtttccct gccacagtct gagaggatcc ataacttcgt atagcataca ttatacgaag     3960

ttatcgtacg agatcccaga catgataaga tacattgatg agtttggaca aaccacaact     4020

agaatgcagt gaaaaaaatg ctttatttgt gaaatttgtg atgctattgc tttatttgta     4080

accattataa gctgcaataa acaagttaac aacaacaatt gcattcattt tatgtttcag     4140

gttcaggggg aggtgtggga ggttttttaa agcatcgtta tcgatgctag cctagtaata     4200

aaccggacat tcgaaaggct gcggtcgaac tctagttgct ctagagcatg gctacgtaga     4260

taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac     4320

tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc     4380

gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agagagggag tggcca         4436


<210>  23
<211>  5224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV vector according to the second aspect of the invention with 
       an arrangement of elements according to alternative (a

<400>  23
tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc       60

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga gagggagtgg      120

ccaactccat cactaggggt tccttgtagt taatgattaa cccgccatgc tacttatcta      180

cgtagccatg ctctagagca agatcgaatt caattcttcg aaggcgcgat aacttcgtat      240

agcatacatt atacgaagtt atggcgcgcc ttaatagtaa tcaattacgg ggtcattagt      300

tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg      360

accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc      420

aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc      480

agtacatcaa gtgtatcata tgccaagtcc gccccctatt gacgtcaatg acggtaaatg      540

gcccgcctgg cattatgccc agtacatgac cttacgggac tttcctactt ggcagtacat      600

ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca ccaatgggcg      660

tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag      720

tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaataacc ccgccccgtt      780

gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctcgtttagt      840

gaaccgtcag atcactagaa gctttattgc ggtagtttat cacagttaaa ttgctaacgc      900

agtcacttaa gataacttcg tatagcatac attatacgaa gttatatgca tttaaggcca      960

ccatggcttc caaggtgtac gaccccgagc aacgcaaacg catgatcact gggcctcagt     1020

ggtgggctcg ctgcaagcaa atgaacgtgc tggactcctt catcaactac tatgattccg     1080

agaagcacgc cgagaacgcc gtgatttttc tgcatggtaa cgctgcctcc agctacctgt     1140

ggaggcacgt cgtgcctcac atcgagcccg tggctagatg catcatccct gatctgatcg     1200

gaatgggtaa gtccggcaag agcgggaatg gctcatatcg cctcctggat cactacaagt     1260

acctcaccgc ttggttcgag ctgctgaacc ttccaaagaa aatcatcttt gtgggccacg     1320

actggggggc ttgtctggcc tttcactact cctacgagca ccaagacaag atcaaggcca     1380

tcgtccatgc tgagagtgtc gtggacgtga tcgagtcctg ggacgagtgg cctgacatcg     1440

aggaggatat cgccctgatc aagagcgaag agggcgagaa aatggtgctt gagaataact     1500

tcttcgtcga gaccatgctc ccaagcaaga tcatgcggaa actggagcct gaggagttcg     1560

ctgcctacct ggagccattc aaggagaagg gcgaggttag acggcctacc ctctcctggc     1620

ctcgcgagat ccctctcgtt aagggaggca agcccgacgt cgtccagatt gtccgcaact     1680

acaacgccta ccttcgggcc agcgacgatc tgcctaagat gttcatcgag tccgaccctg     1740

ggttcttttc caacgctatt gtcgagggag ctaagaagtt ccctaacacc gagttcgtga     1800

aggtgaaggg cctccacttc agccaggagg acgctccaga tgaaatgggt aagtacatca     1860

agagcttcgt ggagcgcgtg ctgaagaacg agcagtaaac cggtcagaca tgataagata     1920

cattgatgag tttggacaaa ccacaactag aatgcagtga aaaaaatgct ttatttgtga     1980

aatttgtgat gctattgctt tatttgtaac cattataagc tgcaataaac aagttaacaa     2040

caacaattgc attcatttta tgtttcaggt tcagggggag gtgtgggagg ttttttaaag     2100

ggcgccttaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg     2160

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt     2220

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca     2280

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc     2340

aagtccgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta     2400

catgacctta cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac     2460

catggtgatg cggttttggc agtacaccaa tgggcgtgga tagcggtttg actcacgggg     2520

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg     2580

ggactttcca aaatgtcgta ataaccccgc cccgttgacg caaatgggcg gtaggcgtgt     2640

acggtgggag gtctatataa gcagagctcg tttagtgaac cgtcagatca ctagaagctt     2700

tattgcggta gtttatcaca gttaaattgc taacgcagtc acctgcaggc cgcgggtacc     2760

gtccaccatg gatatctcca acctgctgac tgtgcaccaa aacctgcctg ccctccctgt     2820

ggatgccacc tctgatgaag tcaggaagaa cctgatggac atgttcaggg acaggcaggc     2880

cttctctgaa cacacctgga agatgctcct gtctgtgtgc agatcctggg ctgcctggtg     2940

caagctgaac aacaggaaat ggttccctgc tgaacctgag gatgtgaggg actacctcct     3000

gtacctgcaa gccagaggcc tggctgtgaa gaccatccaa cagcacctgg gccagctcaa     3060

catgctgcac aggagatctg gcctgcctcg cccttctgac tccaatgctg tgtccctggt     3120

gatgaggaga atcagaaagg agaatgtgga tgctggggag agagccaagc aggccctggc     3180

ctttgaacgc actgactttg accaagtcag atccctgatg gagaactctg acagatgcca     3240

ggacatcagg aacctggcct tcctgggcat tgcctacaac accctgctgc gcattgccga     3300

aattgccaga atcagagtga aggacatctc ccgcaccgat ggtgggagaa tgctgatcca     3360

cattggcagg accaagaccc tggtgtccac agctggtgtg gagaaggccc tgtccctggg     3420

ggttaccaag ctggtggaga gatggatctc tgtgtctggt gtggctgatg accccaacaa     3480

ctacctgttc tgccgggtca gaaagaatgg tgtggctgcc ccttctgcca cctcccaact     3540

gtccacccgg gccctggaag ggatctttga ggccacccac cgcctgatct atggtgccaa     3600

ggatgactct gggcagagat acctggcctg gtctggccac tctgccagag tgggtgctgc     3660

cagggacatg gccagggctg gtgtgtccat ccctgaaatc atgcaggctg gtggctggac     3720

caatgtgaac attgtgatga actacatcag aaacctggac tctgagactg gggccatggt     3780

gaggctgctc gaagatggcg atctcgagcc atctgctgga gacatgagag ctgccaacct     3840

ttggccaagc ccgctcatga tcaaacgctc taagaagaac agcctggcct tgtccctgac     3900

ggccgaccag atggtcagtg ccttgttgga tgctgagccc cccatactct attccgagta     3960

tgatcctacc agacccttca gtgaagcttc gatgatgggc ttactgacca acctggcaga     4020

cagggagctg gttcacatga tcaactgggc gaagagggtg ccaggctttg tggatttgac     4080

cctccatgat caggtccacc ttctagaatg tgcctggcta gagatcctga tgattggtct     4140

cgtctggcgc tccatggagc acccagtgaa gctactgttt gctcctaact tgctcttgga     4200

caggaaccag ggaaaatgtg tagagggcat ggtggagatc ttcgacatgc tgctggctac     4260

atcatctcgg ttccgcatga tgaatctgca gggagaggag tttgtgtgcc tcaaatctat     4320

tattttgctt aattctggag tgtacacatt tctgtccagc accctgaagt ctctggaaga     4380

gaaggaccat atccaccgag tcctggacaa gatcacagac actttgatcc acctgatggc     4440

caaggcaggc ctgaccctgc agcagcagca ccagcggctg gcccagctcc tcctcatcct     4500

ctcccacatc aggcacatga gtaacaaagg catggagcat ctgtacagca tgaagtgcaa     4560

gaacgtggtg cccctctatg acctgctgct ggaggcggcg gacgcccacc gcctacatgc     4620

gcccactagc cgtggagggg catccgtgga ggagacggac caaagccact tggccactgc     4680

gggctctact tcatcgcatt ccttgcaaaa gtattacatc acgggggagg cagagggttt     4740

ccctgccaca gtctgagagg atcccagaca tgataagata cattgatgag tttggacaaa     4800

ccacaactag aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt     4860

tatttgtaac cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta     4920

tgtttcaggt tcagggggag gtgtgggagg ttttttaaag catcgttatc gatgctagcc     4980

tagtaataaa ccggacattc gaaaggctgc ggtcgaactc tagttgctct agagcatggc     5040

tacgtagata agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag     5100

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     5160

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg     5220

gcca                                                                  5224


<210>  24
<211>  5224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV vector according to the second aspect of the invention with 
       an arrangement of elements according to alternative (b)

<400>  24
tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc       60

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga gagggagtgg      120

ccaactccat cactaggggt tccttgtagt taatgattaa cccgccatgc tacttatcta      180

cgtagccatg ctctagagca agatcgaatt caattcttcg aaggcgcgcc ttaatagtaa      240

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      300

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      360

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      420

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc gccccctatt      480

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttacgggac      540

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      600

tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      660

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      720

cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      780

ataagcagag ctcgtttagt gaaccgtcag atcactagaa gctttattgc ggtagtttat      840

cacagttaaa ttgctaacgc agtcacttaa gataacttcg tatagcatac attatacgaa      900

gttatatgca tttaaggcca ccatggcttc caaggtgtac gaccccgagc aacgcaaacg      960

catgatcact gggcctcagt ggtgggctcg ctgcaagcaa atgaacgtgc tggactcctt     1020

catcaactac tatgattccg agaagcacgc cgagaacgcc gtgatttttc tgcatggtaa     1080

cgctgcctcc agctacctgt ggaggcacgt cgtgcctcac atcgagcccg tggctagatg     1140

catcatccct gatctgatcg gaatgggtaa gtccggcaag agcgggaatg gctcatatcg     1200

cctcctggat cactacaagt acctcaccgc ttggttcgag ctgctgaacc ttccaaagaa     1260

aatcatcttt gtgggccacg actggggggc ttgtctggcc tttcactact cctacgagca     1320

ccaagacaag atcaaggcca tcgtccatgc tgagagtgtc gtggacgtga tcgagtcctg     1380

ggacgagtgg cctgacatcg aggaggatat cgccctgatc aagagcgaag agggcgagaa     1440

aatggtgctt gagaataact tcttcgtcga gaccatgctc ccaagcaaga tcatgcggaa     1500

actggagcct gaggagttcg ctgcctacct ggagccattc aaggagaagg gcgaggttag     1560

acggcctacc ctctcctggc ctcgcgagat ccctctcgtt aagggaggca agcccgacgt     1620

cgtccagatt gtccgcaact acaacgccta ccttcgggcc agcgacgatc tgcctaagat     1680

gttcatcgag tccgaccctg ggttcttttc caacgctatt gtcgagggag ctaagaagtt     1740

ccctaacacc gagttcgtga aggtgaaggg cctccacttc agccaggagg acgctccaga     1800

tgaaatgggt aagtacatca agagcttcgt ggagcgcgtg ctgaagaacg agcagtaaac     1860

cggtataact tcgtatagca tacattatac gaagttatgt ttaaacccgg tcagacatga     1920

taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta     1980

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag     2040

ttaacaacaa caattgcatt cattttatgt ttcaggttca gggggaggtg tgggaggttt     2100

tttaaagggc gccttaatag taatcaatta cggggtcatt agttcatagc ccatatatgg     2160

agttccgcgt tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc     2220

gcccattgac gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt     2280

gacgtcaatg ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc     2340

atatgccaag tccgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg     2400

cccagtacat gaccttacgg gactttccta cttggcagta catctacgta ttagtcatcg     2460

ctattaccat ggtgatgcgg ttttggcagt acaccaatgg gcgtggatag cggtttgact     2520

cacggggatt tccaagtctc caccccattg acgtcaatgg gagtttgttt tggcaccaaa     2580

atcaacggga ctttccaaaa tgtcgtaata accccgcccc gttgacgcaa atgggcggta     2640

ggcgtgtacg gtgggaggtc tatataagca gagctcgttt agtgaaccgt cagatcacta     2700

gaagctttat tgcggtagtt tatcacagtt aaattgctaa cgcagtcacc tgcaggccgc     2760

gggtaccgtc caccatggat atctccaacc tgctgactgt gcaccaaaac ctgcctgccc     2820

tccctgtgga tgccacctct gatgaagtca ggaagaacct gatggacatg ttcagggaca     2880

ggcaggcctt ctctgaacac acctggaaga tgctcctgtc tgtgtgcaga tcctgggctg     2940

cctggtgcaa gctgaacaac aggaaatggt tccctgctga acctgaggat gtgagggact     3000

acctcctgta cctgcaagcc agaggcctgg ctgtgaagac catccaacag cacctgggcc     3060

agctcaacat gctgcacagg agatctggcc tgcctcgccc ttctgactcc aatgctgtgt     3120

ccctggtgat gaggagaatc agaaaggaga atgtggatgc tggggagaga gccaagcagg     3180

ccctggcctt tgaacgcact gactttgacc aagtcagatc cctgatggag aactctgaca     3240

gatgccagga catcaggaac ctggccttcc tgggcattgc ctacaacacc ctgctgcgca     3300

ttgccgaaat tgccagaatc agagtgaagg acatctcccg caccgatggt gggagaatgc     3360

tgatccacat tggcaggacc aagaccctgg tgtccacagc tggtgtggag aaggccctgt     3420

ccctgggggt taccaagctg gtggagagat ggatctctgt gtctggtgtg gctgatgacc     3480

ccaacaacta cctgttctgc cgggtcagaa agaatggtgt ggctgcccct tctgccacct     3540

cccaactgtc cacccgggcc ctggaaggga tctttgaggc cacccaccgc ctgatctatg     3600

gtgccaagga tgactctggg cagagatacc tggcctggtc tggccactct gccagagtgg     3660

gtgctgccag ggacatggcc agggctggtg tgtccatccc tgaaatcatg caggctggtg     3720

gctggaccaa tgtgaacatt gtgatgaact acatcagaaa cctggactct gagactgggg     3780

ccatggtgag gctgctcgaa gatggcgatc tcgagccatc tgctggagac atgagagctg     3840

ccaacctttg gccaagcccg ctcatgatca aacgctctaa gaagaacagc ctggccttgt     3900

ccctgacggc cgaccagatg gtcagtgcct tgttggatgc tgagcccccc atactctatt     3960

ccgagtatga tcctaccaga cccttcagtg aagcttcgat gatgggctta ctgaccaacc     4020

tggcagacag ggagctggtt cacatgatca actgggcgaa gagggtgcca ggctttgtgg     4080

atttgaccct ccatgatcag gtccaccttc tagaatgtgc ctggctagag atcctgatga     4140

ttggtctcgt ctggcgctcc atggagcacc cagtgaagct actgtttgct cctaacttgc     4200

tcttggacag gaaccaggga aaatgtgtag agggcatggt ggagatcttc gacatgctgc     4260

tggctacatc atctcggttc cgcatgatga atctgcaggg agaggagttt gtgtgcctca     4320

aatctattat tttgcttaat tctggagtgt acacatttct gtccagcacc ctgaagtctc     4380

tggaagagaa ggaccatatc caccgagtcc tggacaagat cacagacact ttgatccacc     4440

tgatggccaa ggcaggcctg accctgcagc agcagcacca gcggctggcc cagctcctcc     4500

tcatcctctc ccacatcagg cacatgagta acaaaggcat ggagcatctg tacagcatga     4560

agtgcaagaa cgtggtgccc ctctatgacc tgctgctgga ggcggcggac gcccaccgcc     4620

tacatgcgcc cactagccgt ggaggggcat ccgtggagga gacggaccaa agccacttgg     4680

ccactgcggg ctctacttca tcgcattcct tgcaaaagta ttacatcacg ggggaggcag     4740

agggtttccc tgccacagtc tgagaggatc ccagacatga taagatacat tgatgagttt     4800

ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct     4860

attgctttat ttgtaaccat tataagctgc aataaacaag ttaacaacaa caattgcatt     4920

cattttatgt ttcaggttca gggggaggtg tgggaggttt tttaaagcat cgttatcgat     4980

gctagcctag taataaaccg gacattcgaa aggctgcggt cgaactctag ttgctctaga     5040

gcatggctac gtagataagt agcatggcgg gttaatcatt aactacaagg aacccctagt     5100

gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg ggcgaccaaa     5160

ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg agcgagcgag cgcgcagaga     5220

ggga                                                                  5224


<210>  25
<211>  5222
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV vector according to the second aspect of the invention with 
       an arrangement of elements according to alternative (c)

<400>  25
tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc       60

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga gagggagtgg      120

ccaactccat cactaggggt tccttgtagt taatgattaa cccgccatgc tacttatcta      180

cgtagccatg ctctagagca agatcgaatt caattcttcg aaggcgcgat aacttcgtat      240

agcatacatt atacgaagtt atggcgcgcc ttaatagtaa tcaattacgg ggtcattagt      300

tcatagccca tatatggagt tccgcgttac ataacttacg gtaaatggcc cgcctggctg      360

accgcccaac gacccccgcc cattgacgtc aataatgacg tatgttccca tagtaacgcc      420

aatagggact ttccattgac gtcaatgggt ggagtattta cggtaaactg cccacttggc      480

agtacatcaa gtgtatcata tgccaagtcc gccccctatt gacgtcaatg acggtaaatg      540

gcccgcctgg cattatgccc agtacatgac cttacgggac tttcctactt ggcagtacat      600

ctacgtatta gtcatcgcta ttaccatggt gatgcggttt tggcagtaca ccaatgggcg      660

tggatagcgg tttgactcac ggggatttcc aagtctccac cccattgacg tcaatgggag      720

tttgttttgg caccaaaatc aacgggactt tccaaaatgt cgtaataacc ccgccccgtt      780

gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat ataagcagag ctcgtttagt      840

gaaccgtcag atcactagaa gctttattgc ggtagtttat cacagttaaa ttgctaacgc      900

agtcacttaa ggccaccatg gcttccaagg tgtacgaccc cgagcaacgc aaacgcatga      960

tcactgggcc tcagtggtgg gctcgctgca agcaaatgaa cgtgctggac tccttcatca     1020

actactatga ttccgagaag cacgccgaga acgccgtgat ttttctgcat ggtaacgctg     1080

cctccagcta cctgtggagg cacgtcgtgc ctcacatcga gcccgtggct agatgcatca     1140

tccctgatct gatcggaatg ggtaagtccg gcaagagcgg gaatggctca tatcgcctcc     1200

tggatcacta caagtacctc accgcttggt tcgagctgct gaaccttcca aagaaaatca     1260

tctttgtggg ccacgactgg ggggcttgtc tggcctttca ctactcctac gagcaccaag     1320

acaagatcaa ggccatcgtc catgctgaga gtgtcgtgga cgtgatcgag tcctgggacg     1380

agtggcctga catcgaggag gatatcgccc tgatcaagag cgaagagggc gagaaaatgg     1440

tgcttgagaa taacttcttc gtcgagacca tgctcccaag caagatcatg cggaaactgg     1500

agcctgagga gttcgctgcc tacctggagc cattcaagga gaagggcgag gttagacggc     1560

ctaccctctc ctggcctcgc gagatccctc tcgttaaggg aggcaagccc gacgtcgtcc     1620

agattgtccg caactacaac gcctaccttc gggccagcga cgatctgcct aagatgttca     1680

tcgagtccga ccctgggttc ttttccaacg ctattgtcga gggagctaag aagttcccta     1740

acaccgagtt cgtgaaggtg aagggcctcc acttcagcca ggaggacgct ccagatgaaa     1800

tgggtaagta catcaagagc ttcgtggagc gcgtgctgaa gaacgagcag taaaccggta     1860

taacttcgta tagcatacat tatacgaagt tatgtttaaa cccggtcaga catgataaga     1920

tacattgatg agtttggaca aaccacaact agaatgcagt gaaaaaaatg ctttatttgt     1980

gaaatttgtg atgctattgc tttatttgta accattataa gctgcaataa acaagttaac     2040

aacaacaatt gcattcattt tatgtttcag gttcaggggg aggtgtggga ggttttttgg     2100

cgccttaata gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg     2160

ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga     2220

cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat     2280

gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa     2340

gtccgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca     2400

tgaccttacg ggactttcct acttggcagt acatctacgt attagtcatc gctattacca     2460

tggtgatgcg gttttggcag tacaccaatg ggcgtggata gcggtttgac tcacggggat     2520

ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg     2580

actttccaaa atgtcgtaat aaccccgccc cgttgacgca aatgggcggt aggcgtgtac     2640

ggtgggaggt ctatataagc agagctcgtt tagtgaaccg tcagatcact agaagcttta     2700

ttgcggtagt ttatcacagt taaattgcta acgcagtcac ctgcaggccg cgggtaccgt     2760

ccaccatgga tatctccaac ctgctgactg tgcaccaaaa cctgcctgcc ctccctgtgg     2820

atgccacctc tgatgaagtc aggaagaacc tgatggacat gttcagggac aggcaggcct     2880

tctctgaaca cacctggaag atgctcctgt ctgtgtgcag atcctgggct gcctggtgca     2940

agctgaacaa caggaaatgg ttccctgctg aacctgagga tgtgagggac tacctcctgt     3000

acctgcaagc cagaggcctg gctgtgaaga ccatccaaca gcacctgggc cagctcaaca     3060

tgctgcacag gagatctggc ctgcctcgcc cttctgactc caatgctgtg tccctggtga     3120

tgaggagaat cagaaaggag aatgtggatg ctggggagag agccaagcag gccctggcct     3180

ttgaacgcac tgactttgac caagtcagat ccctgatgga gaactctgac agatgccagg     3240

acatcaggaa cctggccttc ctgggcattg cctacaacac cctgctgcgc attgccgaaa     3300

ttgccagaat cagagtgaag gacatctccc gcaccgatgg tgggagaatg ctgatccaca     3360

ttggcaggac caagaccctg gtgtccacag ctggtgtgga gaaggccctg tccctggggg     3420

ttaccaagct ggtggagaga tggatctctg tgtctggtgt ggctgatgac cccaacaact     3480

acctgttctg ccgggtcaga aagaatggtg tggctgcccc ttctgccacc tcccaactgt     3540

ccacccgggc cctggaaggg atctttgagg ccacccaccg cctgatctat ggtgccaagg     3600

atgactctgg gcagagatac ctggcctggt ctggccactc tgccagagtg ggtgctgcca     3660

gggacatggc cagggctggt gtgtccatcc ctgaaatcat gcaggctggt ggctggacca     3720

atgtgaacat tgtgatgaac tacatcagaa acctggactc tgagactggg gccatggtga     3780

ggctgctcga agatggcgat ctcgagccat ctgctggaga catgagagct gccaaccttt     3840

ggccaagccc gctcatgatc aaacgctcta agaagaacag cctggccttg tccctgacgg     3900

ccgaccagat ggtcagtgcc ttgttggatg ctgagccccc catactctat tccgagtatg     3960

atcctaccag acccttcagt gaagcttcga tgatgggctt actgaccaac ctggcagaca     4020

gggagctggt tcacatgatc aactgggcga agagggtgcc aggctttgtg gatttgaccc     4080

tccatgatca ggtccacctt ctagaatgtg cctggctaga gatcctgatg attggtctcg     4140

tctggcgctc catggagcac ccagtgaagc tactgtttgc tcctaacttg ctcttggaca     4200

ggaaccaggg aaaatgtgta gagggcatgg tggagatctt cgacatgctg ctggctacat     4260

catctcggtt ccgcatgatg aatctgcagg gagaggagtt tgtgtgcctc aaatctatta     4320

ttttgcttaa ttctggagtg tacacatttc tgtccagcac cctgaagtct ctggaagaga     4380

aggaccatat ccaccgagtc ctggacaaga tcacagacac tttgatccac ctgatggcca     4440

aggcaggcct gaccctgcag cagcagcacc agcggctggc ccagctcctc ctcatcctct     4500

cccacatcag gcacatgagt aacaaaggca tggagcatct gtacagcatg aagtgcaaga     4560

acgtggtgcc cctctatgac ctgctgctgg aggcggcgga cgcccaccgc ctacatgcgc     4620

ccactagccg tggaggggca tccgtggagg agacggacca aagccacttg gccactgcgg     4680

gctctacttc atcgcattcc ttgcaaaagt attacatcac gggggaggca gagggtttcc     4740

ctgccacagt ctgagaggat cccagacatg ataagataca ttgatgagtt tggacaaacc     4800

acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta     4860

tttgtaacca ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg     4920

tttcaggttc agggggaggt gtgggaggtt ttttaaagca tcgttatcga tgctagccta     4980

gtaataaacc ggacattcga aaggctgcgg tcgaactcta gttgctctag agcatggcta     5040

cgtagataag tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt     5100

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg     5160

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcagag agggagtggc     5220

ca                                                                    5222


<210>  26
<211>  5230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AAV vector according to the second aspect of the invention with 
       an arrangement of elements according to alternative (e)(

<400>  26
tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc       60

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcaga gagggagtgg      120

ccaactccat cactaggggt tccttgtagt taatgattaa cccgccatgc tacttatcta      180

cgtagccatg ctctagagca agatcgaatt caattcttcg aaggcgcgcc ttaatagtaa      240

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      300

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      360

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      420

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtcc gccccctatt      480

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttacgggac      540

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt gatgcggttt      600

tggcagtaca ccaatgggcg tggatagcgg tttgactcac ggggatttcc aagtctccac      660

cccattgacg tcaatgggag tttgttttgg caccaaaatc aacgggactt tccaaaatgt      720

cgtaataacc ccgccccgtt gacgcaaatg ggcggtaggc gtgtacggtg ggaggtctat      780

ataagcagag ctcgtttagt gaaccgtcag atcactagaa gctttattgc ggtagtttat      840

cacagttaaa ttgctaacgc agtcacttaa gataacttcg tatagcatac attatacgaa      900

gttatatgca tttaaggcca ccatggcttc caaggtgtac gaccccgagc aacgcaaacg      960

catgatcact gggcctcagt ggtgggctcg ctgcaagcaa atgaacgtgc tggactcctt     1020

catcaactac tatgattccg agaagcacgc cgagaacgcc gtgatttttc tgcatggtaa     1080

cgctgcctcc agctacctgt ggaggcacgt cgtgcctcac atcgagcccg tggctagatg     1140

catcatccct gatctgatcg gaatgggtaa gtccggcaag agcgggaatg gctcatatcg     1200

cctcctggat cactacaagt acctcaccgc ttggttcgag ctgctgaacc ttccaaagaa     1260

aatcatcttt gtgggccacg actggggggc ttgtctggcc tttcactact cctacgagca     1320

ccaagacaag atcaaggcca tcgtccatgc tgagagtgtc gtggacgtga tcgagtcctg     1380

ggacgagtgg cctgacatcg aggaggatat cgccctgatc aagagcgaag agggcgagaa     1440

aatggtgctt gagaataact tcttcgtcga gaccatgctc ccaagcaaga tcatgcggaa     1500

actggagcct gaggagttcg ctgcctacct ggagccattc aaggagaagg gcgaggttag     1560

acggcctacc ctctcctggc ctcgcgagat ccctctcgtt aagggaggca agcccgacgt     1620

cgtccagatt gtccgcaact acaacgccta ccttcgggcc agcgacgatc tgcctaagat     1680

gttcatcgag tccgaccctg ggttcttttc caacgctatt gtcgagggag ctaagaagtt     1740

ccctaacacc gagttcgtga aggtgaaggg cctccacttc agccaggagg acgctccaga     1800

tgaaatgggt aagtacatca agagcttcgt ggagcgcgtg ctgaagaacg agcagtaaac     1860

cggtcagaca tgataagata cattgatgag tttggacaaa ccacaactag aatgcagtga     1920

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc     1980

tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt tcagggggag     2040

gtgtgggagg ttttttaaag ggcgccttaa tagtaatcaa ttacggggtc attagttcat     2100

agcccatata tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg     2160

cccaacgacc cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata     2220

gggactttcc attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta     2280

catcaagtgt atcatatgcc aagtccgccc cctattgacg tcaatgacgg taaatggccc     2340

gcctggcatt atgcccagta catgacctta cgggactttc ctacttggca gtacatctac     2400

gtattagtca tcgctattac catggtgatg cggttttggc agtacaccaa tgggcgtgga     2460

tagcggtttg actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg     2520

ttttggcacc aaaatcaacg ggactttcca aaatgtcgta ataaccccgc cccgttgacg     2580

caaatgggcg gtaggcgtgt acggtgggag gtctatataa gcagagctcg tttagtgaac     2640

cgtcagatca ctagaagctt tattgcggta gtttatcaca gttaaattgc taacgcagtc     2700

acctgcaggc cgcgggtacc gtccaccatg gatatctcca acctgctgac tgtgcaccaa     2760

aacctgcctg ccctccctgt ggatgccacc tctgatgaag tcaggaagaa cctgatggac     2820

atgttcaggg acaggcaggc cttctctgaa cacacctgga agatgctcct gtctgtgtgc     2880

agatcctggg ctgcctggtg caagctgaac aacaggaaat ggttccctgc tgaacctgag     2940

gatgtgaggg actacctcct gtacctgcaa gccagaggcc tggctgtgaa gaccatccaa     3000

cagcacctgg gccagctcaa catgctgcac aggagatctg gcctgcctcg cccttctgac     3060

tccaatgctg tgtccctggt gatgaggaga atcagaaagg agaatgtgga tgctggggag     3120

agagccaagc aggccctggc ctttgaacgc actgactttg accaagtcag atccctgatg     3180

gagaactctg acagatgcca ggacatcagg aacctggcct tcctgggcat tgcctacaac     3240

accctgctgc gcattgccga aattgccaga atcagagtga aggacatctc ccgcaccgat     3300

ggtgggagaa tgctgatcca cattggcagg accaagaccc tggtgtccac agctggtgtg     3360

gagaaggccc tgtccctggg ggttaccaag ctggtggaga gatggatctc tgtgtctggt     3420

gtggctgatg accccaacaa ctacctgttc tgccgggtca gaaagaatgg tgtggctgcc     3480

ccttctgcca cctcccaact gtccacccgg gccctggaag ggatctttga ggccacccac     3540

cgcctgatct atggtgccaa ggatgactct gggcagagat acctggcctg gtctggccac     3600

tctgccagag tgggtgctgc cagggacatg gccagggctg gtgtgtccat ccctgaaatc     3660

atgcaggctg gtggctggac caatgtgaac attgtgatga actacatcag aaacctggac     3720

tctgagactg gggccatggt gaggctgctc gaagatggcg atctcgagcc atctgctgga     3780

gacatgagag ctgccaacct ttggccaagc ccgctcatga tcaaacgctc taagaagaac     3840

agcctggcct tgtccctgac ggccgaccag atggtcagtg ccttgttgga tgctgagccc     3900

cccatactct attccgagta tgatcctacc agacccttca gtgaagcttc gatgatgggc     3960

ttactgacca acctggcaga cagggagctg gttcacatga tcaactgggc gaagagggtg     4020

ccaggctttg tggatttgac cctccatgat caggtccacc ttctagaatg tgcctggcta     4080

gagatcctga tgattggtct cgtctggcgc tccatggagc acccagtgaa gctactgttt     4140

gctcctaact tgctcttgga caggaaccag ggaaaatgtg tagagggcat ggtggagatc     4200

ttcgacatgc tgctggctac atcatctcgg ttccgcatga tgaatctgca gggagaggag     4260

tttgtgtgcc tcaaatctat tattttgctt aattctggag tgtacacatt tctgtccagc     4320

accctgaagt ctctggaaga gaaggaccat atccaccgag tcctggacaa gatcacagac     4380

actttgatcc acctgatggc caaggcaggc ctgaccctgc agcagcagca ccagcggctg     4440

gcccagctcc tcctcatcct ctcccacatc aggcacatga gtaacaaagg catggagcat     4500

ctgtacagca tgaagtgcaa gaacgtggtg cccctctatg acctgctgct ggaggcggcg     4560

gacgcccacc gcctacatgc gcccactagc cgtggagggg catccgtgga ggagacggac     4620

caaagccact tggccactgc gggctctact tcatcgcatt ccttgcaaaa gtattacatc     4680

acgggggagg cagagggttt ccctgccaca gtctgagagg atccataact tcgtatagca     4740

tacattatac gaagttatcg tacgagatcc cagacatgat aagatacatt gatgagtttg     4800

gacaaaccac aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta     4860

ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac aattgcattc     4920

attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaaagcatc gttatcgatg     4980

ctagcctagt aataaaccgg acattcgaaa ggctgcggtc gaactctagt tgctctagag     5040

catggctacg tagataagta gcatggcggg ttaatcatta actacaagga acccctagtg     5100

atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag     5160

gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcagagag     5220

ggagtggcca                                                            5230


<210>  27
<211>  66
<212>  DNA
<213>  Porcine teschovirus-1

<400>  27
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  28
<211>  1989
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid encoding CRE recombinase linked to a mutant estrogen
       receptor allowing regulation of recombinase activity

<400>  28
atggatatct ccaacctgct gactgtgcac caaaacctgc ctgccctccc tgtggatgcc       60

acctctgatg aagtcaggaa gaacctgatg gacatgttca gggacaggca ggccttctct      120

gaacacacct ggaagatgct cctgtctgtg tgcagatcct gggctgcctg gtgcaagctg      180

aacaacagga aatggttccc tgctgaacct gaggatgtga gggactacct cctgtacctg      240

caagccagag gcctggctgt gaagaccatc caacagcacc tgggccagct caacatgctg      300

cacaggagat ctggcctgcc tcgcccttct gactccaatg ctgtgtccct ggtgatgagg      360

agaatcagaa aggagaatgt ggatgctggg gagagagcca agcaggccct ggcctttgaa      420

cgcactgact ttgaccaagt cagatccctg atggagaact ctgacagatg ccaggacatc      480

aggaacctgg ccttcctggg cattgcctac aacaccctgc tgcgcattgc cgaaattgcc      540

agaatcagag tgaaggacat ctcccgcacc gatggtggga gaatgctgat ccacattggc      600

aggaccaaga ccctggtgtc cacagctggt gtggagaagg ccctgtccct gggggttacc      660

aagctggtgg agagatggat ctctgtgtct ggtgtggctg atgaccccaa caactacctg      720

ttctgccggg tcagaaagaa tggtgtggct gccccttctg ccacctccca actgtccacc      780

cgggccctgg aagggatctt tgaggccacc caccgcctga tctatggtgc caaggatgac      840

tctgggcaga gatacctggc ctggtctggc cactctgcca gagtgggtgc tgccagggac      900

atggccaggg ctggtgtgtc catccctgaa atcatgcagg ctggtggctg gaccaatgtg      960

aacattgtga tgaactacat cagaaacctg gactctgaga ctggggccat ggtgaggctg     1020

ctcgaagatg gcgatctcga gccatctgct ggagacatga gagctgccaa cctttggcca     1080

agcccgctca tgatcaaacg ctctaagaag aacagcctgg ccttgtccct gacggccgac     1140

cagatggtca gtgccttgtt ggatgctgag ccccccatac tctattccga gtatgatcct     1200

accagaccct tcagtgaagc ttcgatgatg ggcttactga ccaacctggc agacagggag     1260

ctggttcaca tgatcaactg ggcgaagagg gtgccaggct ttgtggattt gaccctccat     1320

gatcaggtcc accttctaga atgtgcctgg ctagagatcc tgatgattgg tctcgtctgg     1380

cgctccatgg agcacccagt gaagctactg tttgctccta acttgctctt ggacaggaac     1440

cagggaaaat gtgtagaggg catggtggag atcttcgaca tgctgctggc tacatcatct     1500

cggttccgca tgatgaatct gcagggagag gagtttgtgt gcctcaaatc tattattttg     1560

cttaattctg gagtgtacac atttctgtcc agcaccctga agtctctgga agagaaggac     1620

catatccacc gagtcctgga caagatcaca gacactttga tccacctgat ggccaaggca     1680

ggcctgaccc tgcagcagca gcaccagcgg ctggcccagc tcctcctcat cctctcccac     1740

atcaggcaca tgagtaacaa aggcatggag catctgtaca gcatgaagtg caagaacgtg     1800

gtgcccctct atgacctgct gctggaggcg gcggacgccc accgcctaca tgcgcccact     1860

agccgtggag gggcatccgt ggaggagacg gaccaaagcc acttggccac tgcgggctct     1920

acttcatcgc attccttgca aaagtattac atcacggggg aggcagaggg tttccctgcc     1980

acagtctga                                                             1989


<210>  29
<211>  936
<212>  DNA
<213>  Renilla reniformis

<400>  29
atggcttcca aggtgtacga ccccgagcaa cgcaaacgca tgatcactgg gcctcagtgg       60

tgggctcgct gcaagcaaat gaacgtgctg gactccttca tcaactacta tgattccgag      120

aagcacgccg agaacgccgt gatttttctg catggtaacg ctgcctccag ctacctgtgg      180

aggcacgtcg tgcctcacat cgagcccgtg gctagatgca tcatccctga tctgatcgga      240

atgggtaagt ccggcaagag cgggaatggc tcatatcgcc tcctggatca ctacaagtac      300

ctcaccgctt ggttcgagct gctgaacctt ccaaagaaaa tcatctttgt gggccacgac      360

tggggggctt gtctggcctt tcactactcc tacgagcacc aagacaagat caaggccatc      420

gtccatgctg agagtgtcgt ggacgtgatc gagtcctggg acgagtggcc tgacatcgag      480

gaggatatcg ccctgatcaa gagcgaagag ggcgagaaaa tggtgcttga gaataacttc      540

ttcgtcgaga ccatgctccc aagcaagatc atgcggaaac tggagcctga ggagttcgct      600

gcctacctgg agccattcaa ggagaagggc gaggttagac ggcctaccct ctcctggcct      660

cgcgagatcc ctctcgttaa gggaggcaag cccgacgtcg tccagattgt ccgcaactac      720

aacgcctacc ttcgggccag cgacgatctg cctaagatgt tcatcgagtc cgaccctggg      780

ttcttttcca acgctattgt cgagggagct aagaagttcc ctaacaccga gttcgtgaag      840

gtgaagggcc tccacttcag ccaggaggac gctccagatg aaatgggtaa gtacatcaag      900

agcttcgtgg agcgcgtgct gaagaacgag cagtaa                                936


<210>  30
<211>  567
<212>  DNA
<213>  Mus musculus

<400>  30
atggtgagca agggcgagga gctgttcact atgcctggct cagcactgct atgctgcctg       60

ctcttactga ctggcatgag gatcagcagg ggccagtaca gccgggaaga caataactgc      120

acccacttcc cagtcggcca gagccacatg ctcctagagc tgcggactgc cttcagccag      180

gtgaagactt tctttcaaac aaaggaccag ctggacaaca tactgctaac cgactcctta      240

atgcaggact ttaagggtta cttgggttgc caagccttat cggaaatgat ccagttttac      300

ctggtagaag tgatgcccca ggcagagaag catggcccag aaatcaagga gcatttgaat      360

tccctgggtg agaagctgaa gaccctcagg atgcggctga ggcgctgtca tcgatttctc      420

ccctgtgaaa ataagagcaa ggcagtggag caggtgaaga gtgattttaa taagctccaa      480

gaccaaggtg tctacaaggc catgaatgaa tttgacatct tcatcaactg catagaagca      540

tacatgatga tcaaaatgaa aagctaa                                          567


<210>  31
<211>  188
<212>  PRT
<213>  Mus musculus

<400>  31

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Met Pro Gly Ser Ala Leu 
1               5                   10                  15      


Leu Cys Cys Leu Leu Leu Leu Thr Gly Met Arg Ile Ser Arg Gly Gln 
            20                  25                  30          


Tyr Ser Arg Glu Asp Asn Asn Cys Thr His Phe Pro Val Gly Gln Ser 
        35                  40                  45              


His Met Leu Leu Glu Leu Arg Thr Ala Phe Ser Gln Val Lys Thr Phe 
    50                  55                  60                  


Phe Gln Thr Lys Asp Gln Leu Asp Asn Ile Leu Leu Thr Asp Ser Leu 
65                  70                  75                  80  


Met Gln Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu Met 
                85                  90                  95      


Ile Gln Phe Tyr Leu Val Glu Val Met Pro Gln Ala Glu Lys His Gly 
            100                 105                 110         


Pro Glu Ile Lys Glu His Leu Asn Ser Leu Gly Glu Lys Leu Lys Thr 
        115                 120                 125             


Leu Arg Met Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu Asn 
    130                 135                 140                 


Lys Ser Lys Ala Val Glu Gln Val Lys Ser Asp Phe Asn Lys Leu Gln 
145                 150                 155                 160 


Asp Gln Gly Val Tyr Lys Ala Met Asn Glu Phe Asp Ile Phe Ile Asn 
                165                 170                 175     


Cys Ile Glu Ala Tyr Met Met Ile Lys Met Lys Ser 
            180                 185             


