                         SEQUENCE LISTING

<110>  Muthumani , Karuppiah
       Weiner , David
       Yan , Jian
 
<120>  COMBINATION OF NOVEL VACCINES AGAINST ZIKA VIRUS AND DNA ANTIBODY
        CONSTRUCTS FOR USE AGAINST ZIKA VIRUS

<130>  206194-0008-00-WO.606794

<150>  62/396,750
<151>  2016-09-19

<150>  62/417,093
<151>  2016-11-03

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-3F12E9-VH

<400>  1

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Gly Met Ser Trp Gly Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Trp Phe Ala Tyr Trp Gly Arg Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala 
    130             


<210>  2
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-3F12E9-VL

<400>  2

Met Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg 
1               5                   10                  15      


Glu Thr Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser 
            20                  25                  30          


Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr 
            100                 105                 110         


Cys Trp Gln Gly Thr His Phe Pro His Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys 
    130         


<210>  3
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-8A9F9-VH

<400>  3

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser 
    130                 


<210>  4
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-8A9F9-VL

<400>  4

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Arg Ser Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Phe Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  5
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-8D10F4-VH

<400>  5

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Lys Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr 
        


<210>  6
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-8D10F4-VL

<400>  6

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Phe His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys 
            100                 105                 110         


Ser Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  7
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-IC2A6-VH

<400>  7

Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser 
    130                 


<210>  8
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-IC2A6-VH

<400>  8

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Cys Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Phe Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  9
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-ID4G7-VH

<400>  9

Met Ala Trp Val Trp Thr Leu Leu Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Ala Gln Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Ile Ser Lys Ile Tyr Tyr Tyr Gly Ser Ser 
        115                 120                 125             


Tyr Glu Asn Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
    130                 135                 140                 


Ser Ser 
145     


<210>  10
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZIKV-ID4G7-VL

<400>  10

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Asp Ser Phe Gly Asn Ser Phe Met His Trp Phe Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Asp Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Asn Asn Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  11
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (3F12E9)-IgG4: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  11

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Gly Met Ser Trp Gly Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Trp Phe Ala Tyr Trp Gly Arg Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Ser Pro Asn Met Val Pro His Ala His 
225                 230                 235                 240 


His Ala Gln Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
                245                 250                 255     


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            260                 265                 270         


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
        275                 280                 285             


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    290                 295                 300                 


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
305                 310                 315                 320 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                325                 330                 335     


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
            340                 345                 350         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
        355                 360                 365             


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    370                 375                 380                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
385                 390                 395                 400 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                405                 410                 415     


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
            420                 425                 430         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        435                 440                 445             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Arg Gly Arg Lys 
    450                 455                 460                 


Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
465                 470                 475                 480 


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val 
                485                 490                 495     


Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asp Val Val 
            500                 505                 510         


Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly Gln Pro Ala 
        515                 520                 525             


Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys 
    530                 535                 540                 


Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser Pro Lys Arg 
545                 550                 555                 560 


Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro Asp Arg Phe 
                565                 570                 575     


Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 
            580                 585                 590         


Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly Thr His Phe 
        595                 600                 605             


Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val 
    610                 615                 620                 


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
625                 630                 635                 640 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
                645                 650                 655     


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
            660                 665                 670         


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
        675                 680                 685             


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
    690                 695                 700                 


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
705                 710                 715                 720 


Lys Ser Phe Asn Arg Gly Glu Cys 
                725             


<210>  12
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG heavy signal peptide-VH-CH1-Hinge Region-CH2-CH3-custom
       Furin cleavage site-'GSG' Linker and P2A Peptide-human kappa 
       light chain signal peptide-VL-CL (kappa)

<400>  12

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Gly Met Ser Trp Gly Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Trp Phe Ala Tyr Trp Gly Arg Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg 
    450                 455                 460                 


Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
465                 470                 475                 480 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln 
                485                 490                 495     


Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly 
            500                 505                 510         


Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
        515                 520                 525             


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
    530                 535                 540                 


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
545                 550                 555                 560 


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
                565                 570                 575     


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
            580                 585                 590         


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
        595                 600                 605             


Thr His Phe Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
    610                 615                 620                 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
625                 630                 635                 640 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
                645                 650                 655     


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
            660                 665                 670         


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
        675                 680                 685             


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
    690                 695                 700                 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
705                 710                 715                 720 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730     


<210>  13
<211>  729
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG heavy signal peptide-VH-CH1-Hinge Region-CH2-CH3-custom
       Furin cleavage site-'GSG' Linker and P2A Peptide-human kappa 
       light chain signal peptide-VL-CL (kappa)

<400>  13

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Arg Val Ser Pro Asn Met Val Pro His Ala 
225                 230                 235                 240 


His His Ala Gln Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Arg Gly Arg 
    450                 455                 460                 


Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
465                 470                 475                 480 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln 
                485                 490                 495     


Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asp Val 
            500                 505                 510         


Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln 
        515                 520                 525             


Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly 
    530                 535                 540                 


Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys 
545                 550                 555                 560 


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
                565                 570                 575     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
            580                 585                 590         


Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln Ser Thr His 
        595                 600                 605             


Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
    610                 615                 620                 


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
625                 630                 635                 640 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
                645                 650                 655     


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
            660                 665                 670         


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
        675                 680                 685             


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
    690                 695                 700                 


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
705                 710                 715                 720 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 


<210>  14
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (8A9F9)-IgG1: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  14

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
465                 470                 475                 480 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu 
                485                 490                 495     


Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr 
            500                 505                 510         


Gly Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu 
        515                 520                 525             


Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His 
    530                 535                 540                 


Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln 
545                 550                 555                 560 


Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val 
                565                 570                 575     


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
            580                 585                 590         


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln 
        595                 600                 605             


Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
    610                 615                 620                 


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
625                 630                 635                 640 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
                645                 650                 655     


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
            660                 665                 670         


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
        675                 680                 685             


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
    690                 695                 700                 


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
705                 710                 715                 720 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730         


<210>  15
<211>  728
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (8D10F4)-IgG4: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  15

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Arg Val Ser Pro Asn Met Val Pro His Ala 
225                 230                 235                 240 


His His Ala Gln Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Arg Gly Arg 
    450                 455                 460                 


Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln 
465                 470                 475                 480 


Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln 
                485                 490                 495     


Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asp Val 
            500                 505                 510         


Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln 
        515                 520                 525             


Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly 
    530                 535                 540                 


Asn Thr Tyr Phe His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys 
545                 550                 555                 560 


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
                565                 570                 575     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
            580                 585                 590         


Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser Thr His 
        595                 600                 605             


Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Val 
    610                 615                 620                 


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
625                 630                 635                 640 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
                645                 650                 655     


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
            660                 665                 670         


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
        675                 680                 685             


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
    690                 695                 700                 


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
705                 710                 715                 720 


Lys Ser Phe Asn Arg Gly Glu Cys 
                725             


<210>  16
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (8D10F4)-IgG1: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  16

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Ile Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
465                 470                 475                 480 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu 
                485                 490                 495     


Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr 
            500                 505                 510         


Gly Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu 
        515                 520                 525             


Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His 
    530                 535                 540                 


Ser Asn Gly Asn Thr Tyr Phe His Trp Tyr Leu Gln Lys Pro Gly Gln 
545                 550                 555                 560 


Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val 
                565                 570                 575     


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
            580                 585                 590         


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln 
        595                 600                 605             


Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
    610                 615                 620                 


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
625                 630                 635                 640 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
                645                 650                 655     


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
            660                 665                 670         


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
        675                 680                 685             


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
    690                 695                 700                 


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
705                 710                 715                 720 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730         


<210>  17
<211>  740
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (1D4G7)-IgG4: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  17

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Ile Ser Lys Ile Tyr Tyr Tyr Gly Ser Ser 
        115                 120                 125             


Tyr Glu Asn Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
145                 150                 155                 160 


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Arg Val Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
                245                 250                 255     


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Leu Gly Lys Arg Gly Arg Lys Arg Arg Ser 
465                 470                 475                 480 


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
                485                 490                 495     


Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser 
            500                 505                 510         


Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asn Ile Val Leu Thr Gln 
        515                 520                 525             


Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser 
    530                 535                 540                 


Cys Arg Ala Ser Glu Ser Val Asp Ser Phe Gly Asn Ser Phe Met His 
545                 550                 555                 560 


Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu 
                565                 570                 575     


Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly 
            580                 585                 590         


Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu Ala Asp Asp 
        595                 600                 605             


Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Glu Tyr Pro Tyr Thr Phe 
    610                 615                 620                 


Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 
625                 630                 635                 640 


Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 
                645                 650                 655     


Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
            660                 665                 670         


Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 
        675                 680                 685             


Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 
    690                 695                 700                 


Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 
705                 710                 715                 720 


Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 
                725                 730                 735     


Arg Gly Glu Cys 
            740 


<210>  18
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (1D4G7)-IgG1: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  18

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys 
            20                  25                  30          


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Lys Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala 
65                  70                  75                  80  


Asp Asp Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser 
                85                  90                  95      


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Ile Ser Lys Ile Tyr Tyr Tyr Gly Ser Ser 
        115                 120                 125             


Tyr Glu Asn Gly Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Gly Arg Lys 
465                 470                 475                 480 


Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
                485                 490                 495     


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln Thr Gln Val 
            500                 505                 510         


Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly Asn Ile Val 
        515                 520                 525             


Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala 
    530                 535                 540                 


Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Phe Gly Asn Ser 
545                 550                 555                 560 


Phe Met His Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 
                565                 570                 575     


Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser 
            580                 585                 590         


Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Glu 
        595                 600                 605             


Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn Glu Tyr Pro 
    610                 615                 620                 


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala 
625                 630                 635                 640 


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
                645                 650                 655     


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
            660                 665                 670         


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
        675                 680                 685             


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
    690                 695                 700                 


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
705                 710                 715                 720 


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
                725                 730                 735     


Ser Phe Asn Arg Gly Glu Cys 
            740             


<210>  19
<211>  732
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (8A9F9)-IgG1: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2 (with LALA variant at 4th and 5th
       residue)-CH3-custom Furin cleavage site-'GSG' Linker and P2A 
       Peptide-human kappa light chain signal peptide-VL-CL (kappa)

<400>  19

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu 
465                 470                 475                 480 


Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu 
                485                 490                 495     


Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr 
            500                 505                 510         


Gly Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu 
        515                 520                 525             


Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His 
    530                 535                 540                 


Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln 
545                 550                 555                 560 


Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val 
                565                 570                 575     


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys 
            580                 585                 590         


Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe Gln 
        595                 600                 605             


Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
    610                 615                 620                 


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
625                 630                 635                 640 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
                645                 650                 655     


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
            660                 665                 670         


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
        675                 680                 685             


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
    690                 695                 700                 


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
705                 710                 715                 720 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730         


<210>  20
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (3F12E9)-IgG1: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2 (with LALA variant at 4th and 5th
       residue)-CH3-custom Furin cleavage site-'GSG' Linker and P2A 
       Peptide-human kappa light chain signal peptide-VL-CL (kappa)

<400>  20

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Gly Met Ser Trp Gly Arg Gln Thr Pro Asp Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Ser Gly Gly Thr Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ser Trp Phe Ala Tyr Trp Gly Arg Gly Thr Leu 
        115                 120                 125             


Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg 
    450                 455                 460                 


Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
465                 470                 475                 480 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val Leu Gln 
                485                 490                 495     


Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala Tyr Gly 
            500                 505                 510         


Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
        515                 520                 525             


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
    530                 535                 540                 


Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
545                 550                 555                 560 


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
                565                 570                 575     


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
            580                 585                 590         


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
        595                 600                 605             


Thr His Phe Pro His Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
    610                 615                 620                 


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
625                 630                 635                 640 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
                645                 650                 655     


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
            660                 665                 670         


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
        675                 680                 685             


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
    690                 695                 700                 


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
705                 710                 715                 720 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
                725                 730     


<210>  21
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (IC2A6)-IgG4: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  21

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Val Thr Gly Arg Phe Thr Ile Ser Arg Asp 
    130                 135                 140                 


Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu 
145                 150                 155                 160 


Asp Thr Ala Met Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp 
                165                 170                 175     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
            180                 185                 190         


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
        195                 200                 205             


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
    210                 215                 220                 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
225                 230                 235                 240 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
                245                 250                 255     


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
            260                 265                 270         


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Ser Pro Asn Met 
        275                 280                 285             


Val Pro His Ala His His Ala Gln Ala Pro Glu Phe Leu Gly Gly Pro 
    290                 295                 300                 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
305                 310                 315                 320 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
                325                 330                 335     


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
            340                 345                 350         


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
        355                 360                 365             


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
    370                 375                 380                 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
385                 390                 395                 400 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
                405                 410                 415     


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
            420                 425                 430         


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
        435                 440                 445             


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
    450                 455                 460                 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
465                 470                 475                 480 


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
                485                 490                 495     


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
            500                 505                 510         


Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser 
        515                 520                 525             


Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Val 
    530                 535                 540                 


Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser Gly Ala 
545                 550                 555                 560 


Tyr Gly Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Cys 
                565                 570                 575     


Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val 
            580                 585                 590         


His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly 
        595                 600                 605             


Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly 
    610                 615                 620                 


Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
625                 630                 635                 640 


Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Phe 
                645                 650                 655     


Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu 
            660                 665                 670         


Ile Lys Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        675                 680                 685             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    690                 695                 700                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
705                 710                 715                 720 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                725                 730                 735     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            740                 745                 750         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        755                 760                 765             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    770                 775                 780 


<210>  22
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human anti-Zika (IC2A6)-IgG1: Human IgG heavy signal 
       peptide-VH-CH1-Hinge Region-CH2-CH3-custom Furin cleavage 
       site-'GSG' Linker and P2A Peptide-human kappa light chain signal 
       peptide-VL-CL (kappa)

<400>  22

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Thr His Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Val Thr Gly Arg Phe Thr Ile Ser Arg Asp 
    130                 135                 140                 


Asn Ala Lys Asn Thr Leu Tyr Leu Glu Met Ser Ser Leu Arg Ser Glu 
145                 150                 155                 160 


Asp Thr Ala Met Tyr Tyr Cys Ala Ser Asp Gly Tyr Tyr Ser His Trp 
                165                 170                 175     


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
            180                 185                 190         


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
        195                 200                 205             


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
    210                 215                 220                 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
225                 230                 235                 240 


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
                245                 250                 255     


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
            260                 265                 270         


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
        275                 280                 285             


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    290                 295                 300                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
305                 310                 315                 320 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                325                 330                 335     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            340                 345                 350         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        355                 360                 365             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    370                 375                 380                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
385                 390                 395                 400 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                405                 410                 415     


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
            420                 425                 430         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        435                 440                 445             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    450                 455                 460                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
465                 470                 475                 480 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                485                 490                 495     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            500                 505                 510         


Ser Pro Gly Lys Arg Gly Arg Lys Arg Arg Ser Gly Ser Gly Ala Thr 
        515                 520                 525             


Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly 
    530                 535                 540                 


Pro Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile 
545                 550                 555                 560 


Ser Gly Ala Tyr Gly Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu 
                565                 570                 575     


Pro Val Cys Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln 
            580                 585                 590         


Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
        595                 600                 605             


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
    610                 615                 620                 


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
625                 630                 635                 640 


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
                645                 650                 655     


Phe Cys Phe Gln Ser Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr 
            660                 665                 670         


Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
        675                 680                 685             


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
    690                 695                 700                 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
705                 710                 715                 720 


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
                725                 730                 735     


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
            740                 745                 750         


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
        755                 760                 765             


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    770                 775                 780                 


<210>  23
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-prME

<400>  23

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ile Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu 
            20                  25                  30          


Ile Thr Arg Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Asn Asp 
        35                  40                  45              


Ala Gly Glu Ala Ile Ser Phe Pro Thr Thr Leu Gly Met Asn Lys Cys 
    50                  55                  60                  


Tyr Ile Gln Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser 
65                  70                  75                  80  


Tyr Glu Cys Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp 
                85                  90                  95      


Cys Trp Cys Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His 
            100                 105                 110         


His Lys Lys Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro 
        115                 120                 125             


Ser His Ser Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu 
    130                 135                 140                 


Ser Arg Glu Tyr Thr Lys His Leu Ile Arg Val Glu Asn Trp Ile Phe 
145                 150                 155                 160 


Arg Asn Pro Gly Phe Ala Leu Ala Ala Ala Ala Ile Ala Trp Leu Leu 
                165                 170                 175     


Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu 
            180                 185                 190         


Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp 
        195                 200                 205             


Phe Val Glu Gly Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu 
    210                 215                 220                 


His Gly Gly Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp 
225                 230                 235                 240 


Ile Glu Leu Val Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser 
                245                 250                 255     


Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys 
            260                 265                 270         


Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr 
        275                 280                 285             


Val Cys Lys Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly 
    290                 295                 300                 


Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser 
305                 310                 315                 320 


Lys Lys Met Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg 
                325                 330                 335     


Ile Met Leu Ser Val His Gly Ser Gln His Ser Gly Met Ile Val Asn 
            340                 345                 350         


Asp Ile Gly His Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr 
        355                 360                 365             


Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu 
    370                 375                 380                 


Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr 
385                 390                 395                 400 


Tyr Leu Thr Met Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe 
                405                 410                 415     


His Asp Ile Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro 
            420                 425                 430         


His Trp Asn Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala 
        435                 440                 445             


Lys Arg Gln Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His 
    450                 455                 460                 


Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly 
465                 470                 475                 480 


Arg Leu Phe Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu 
                485                 490                 495     


Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe 
            500                 505                 510         


Thr Lys Val Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val 
        515                 520                 525             


Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln Met Ala 
    530                 535                 540                 


Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn 
545                 550                 555                 560 


Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu 
                565                 570                 575     


Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys 
            580                 585                 590         


Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala 
        595                 600                 605             


Phe Glu Ala Thr Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp 
    610                 615                 620                 


Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly 
625                 630                 635                 640 


Lys Gly Ile His Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly 
                645                 650                 655     


Gly Met Ser Trp Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp 
            660                 665                 670         


Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala 
        675                 680                 685             


Leu Gly Gly Val Met Ile Phe Leu Ser Thr Ala Val Ser Ala 
    690                 695                 700         


<210>  24
<211>  2112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-prME (construct 1)

<400>  24
atggactgga cctggattct gtttctggtc gctgctgcta caagagtgca ttctgggatt       60

attggactgc tgctgactac tgccatggca gcagagatca ccaggagagg cagcgcctac      120

tatatgtacc tggaccggtc tgatgccggc aaggccatca gctttgccac cacactgggc      180

gtgaataagt gccacgtgca gatcatggac ctgggccaca tgtgcgatgc caccatgtcc      240

tacgagtgtc caatgctgga cgagggcgtg gagcccgacg atgtggattg ctggtgtaac      300

accacatcta catgggtggt gtatggcacc tgtcaccaca agaagggaga ggcacggcgc      360

agcaggagag cagtgacact gccctctcac agcaccagga agctgcagac aagaagccag      420

acctggctgg agtcccggga gtatacaaag cacctgatca aggtggagaa ctggatcttt      480

cgcaatccag gattcgcact ggtggcagtg gcaatcgcat ggctgctggg cagctccacc      540

tcccagaaag tgatctacct ggtcatgatc ctgctgatcg cccctgccta ttccatcagg      600

tgcatcggcg tgtctaatag agacttcgtg gagggcatgt ctggcggcac ctgggtggat      660

gtggtgctgg agcacggcgg atgcgtgaca gtgatggccc aggacaagcc aaccgtggat      720

atcgagctgg tgaccacaac cgtgagcaac atggccgagg tgaggtccta ctgctatgag      780

gcctccatct ctgacatggc cagcgattcc agatgtccca cccagggcga ggcctacctg      840

gacaagcagt ccgatacaca gtacgtgtgc aagcggaccc tggtggacag gggatgggga      900

aatggatgtg gcctgtttgg caagggctct ctggtgacat gcgccaagtt cacctgttct      960

aagaagatga ccggcaagag catccagccc gagaacctgg agtacaggat catgctgagc     1020

gtgcacggca gccagcactc cggcatgaca gtgaacgaca tcggctatga gaccgatgag     1080

aatagggcca aggtggaggt gacacctaac agcccaagag ccgaggccac cctgggcggc     1140

tttggctccc tgggactgga ctgcgagcct agaacaggcc tggacttctc cgatctgtac     1200

tatctgacca tgaacaataa gcactggctg gtgcacaagg agtggtttca cgacatccca     1260

ctgccatggc acgcaggagc agatacagga accccacact ggaacaataa ggaggccctg     1320

gtggagttca aggatgccca cgccaagcgc cagacagtgg tggtgctggg cagccaggag     1380

ggagcagtgc acaccgccct ggcaggcgcc ctggaggccg agatggacgg cgccaagggc     1440

aagctgtttt ccggccacct gaagtgccgg ctgaagatgg ataagctgcg cctgaagggc     1500

gtgtcttaca gcctgtgcac agccgccttc accttcacca aggtgcctgc cgagaccctg     1560

cacggcacag tgaccgtgga ggtgcagtat gccggcacag acggcccctg taagatccct     1620

gtgcagatgg ccgtggatat gcagacactg acccctgtgg gccggctgat caccgcaaat     1680

ccagtgatca cagagtccac cgagaactct aagatgatgc tggagctgga ccctcccttc     1740

ggcgacagct acatcgtgat cggcgtgggc gacaagaaga tcacacacca ctggcaccgc     1800

tccggctcta caatcggcaa ggccttcgag gcaaccgtgc ggggcgccaa gaggatggcc     1860

gtgctgggcg acaccgcatg ggattttggc tccgtgggcg gcgtgttcaa ctctctgggc     1920

aagggcatcc accagatctt cggcgccgcc tttaagtctc tgttcggcgg aatgtcttgg     1980

ttcagccaga tcctgatcgg cacactgctg gtgtggctgg gcctgaacac caagaatggc     2040

agcatctctc tgacttgtct ggccctggga ggcgtgatga ttttcctgtc cactgccgtg     2100

tctgcctgat aa                                                         2112


<210>  25
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-prME (construct 1)

<400>  25

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ile Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu 
            20                  25                  30          


Ile Thr Arg Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg Ser Asp 
        35                  40                  45              


Ala Gly Lys Ala Ile Ser Phe Ala Thr Thr Leu Gly Val Asn Lys Cys 
    50                  55                  60                  


His Val Gln Ile Met Asp Leu Gly His Met Cys Asp Ala Thr Met Ser 
65                  70                  75                  80  


Tyr Glu Cys Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp Val Asp 
                85                  90                  95      


Cys Trp Cys Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr Cys His 
            100                 105                 110         


His Lys Lys Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr Leu Pro 
        115                 120                 125             


Ser His Ser Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp Leu Glu 
    130                 135                 140                 


Ser Arg Glu Tyr Thr Lys His Leu Ile Lys Val Glu Asn Trp Ile Phe 
145                 150                 155                 160 


Arg Asn Pro Gly Phe Ala Leu Val Ala Val Ala Ile Ala Trp Leu Leu 
                165                 170                 175     


Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile Leu Leu 
            180                 185                 190         


Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn Arg Asp 
        195                 200                 205             


Phe Val Glu Gly Met Ser Gly Gly Thr Trp Val Asp Val Val Leu Glu 
    210                 215                 220                 


His Gly Gly Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr Val Asp 
225                 230                 235                 240 


Ile Glu Leu Val Thr Thr Thr Val Ser Asn Met Ala Glu Val Arg Ser 
                245                 250                 255     


Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser Arg Cys 
            260                 265                 270         


Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr Gln Tyr 
        275                 280                 285             


Val Cys Lys Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly Cys Gly 
    290                 295                 300                 


Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Thr Cys Ser 
305                 310                 315                 320 


Lys Lys Met Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu Tyr Arg 
                325                 330                 335     


Ile Met Leu Ser Val His Gly Ser Gln His Ser Gly Met Thr Val Asn 
            340                 345                 350         


Asp Ile Gly Tyr Glu Thr Asp Glu Asn Arg Ala Lys Val Glu Val Thr 
        355                 360                 365             


Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly Ser Leu 
    370                 375                 380                 


Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp Leu Tyr 
385                 390                 395                 400 


Tyr Leu Thr Met Asn Asn Lys His Trp Leu Val His Lys Glu Trp Phe 
                405                 410                 415     


His Asp Ile Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly Thr Pro 
            420                 425                 430         


His Trp Asn Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala His Ala 
        435                 440                 445             


Lys Arg Gln Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala Val His 
    450                 455                 460                 


Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala Lys Gly 
465                 470                 475                 480 


Lys Leu Phe Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp Lys Leu 
                485                 490                 495     


Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe Thr Phe 
            500                 505                 510         


Thr Lys Val Pro Ala Glu Thr Leu His Gly Thr Val Thr Val Glu Val 
        515                 520                 525             


Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Ile Pro Val Gln Met Ala 
    530                 535                 540                 


Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr Ala Asn 
545                 550                 555                 560 


Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu Glu Leu 
                565                 570                 575     


Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly Asp Lys 
            580                 585                 590         


Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly Lys Ala 
        595                 600                 605             


Phe Glu Ala Thr Val Arg Gly Ala Lys Arg Met Ala Val Leu Gly Asp 
    610                 615                 620                 


Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Phe Asn Ser Leu Gly 
625                 630                 635                 640 


Lys Gly Ile His Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu Phe Gly 
                645                 650                 655     


Gly Met Ser Trp Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu Val Trp 
            660                 665                 670         


Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys Leu Ala 
        675                 680                 685             


Leu Gly Gly Val Met Ile Phe Leu Ser Thr Ala Val Ser Ala 
    690                 695                 700         


<210>  26
<211>  1119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-NS1

<400>  26
atggactgga cttggattct gttcctggtg gctgccgcta caagagtgca tagcgtggga       60

tgcagcgtgg acttcagcaa gaaggagacc cgctgcggaa caggcgtgtt cgtgtacaac      120

gacgtggagg cttggagaga ccggtacaag taccaccccg atagccctag aagactggcc      180

gcagccgtga aacaggcttg ggaagaggga atttgcggca tcagcagcgt gtcccggatg      240

gagaacatca tgtggaagag cgtggagggc gagctgaacg ctatcctgga ggagaacggc      300

gtgcagctga cagtggtcgt gggatcagtg aagaacccca tgtggagagg ccctcagagg      360

ctgccagtgc cagtgaacga actgcctcac ggttggaagg cttggggcaa gagctacttc      420

gtgagggccg ccaagaccaa caacagcttc gtggtggacg gcgataccct caaggagtgt      480

cctctgaagc accgggcttg gaacagcttc ctggtggaag accacggctt tggcgtgttc      540

cacacaagcg tctggctgaa ggtccgcgaa gactacagcc tggagtgcga tccagcagtg      600

atcggcacag ccgtgaaggg aaaagaggcc gctcacagcg acctgggcta ttggatcgag      660

agcgagaaga acgacacttg gaggctgaag cgggcccacc tgatcgagat gaagacttgc      720

gagtggccca agagccacac tctgtggaca gacggcgtgg aagagagcga cctgatcatc      780

cctaagagcc tggccggacc tctgtctcat cacaacacca gggagggcta cagaacccag      840

gtgaagggac cttggcacag cgaagagctg gagatccgct tcgaggagtg tccaggaacc      900

aaggtgcacg tggaggagac ttgcggaacc agaggcccta gcctgagaag cacaacagcc      960

agcggacgcg tgatcgagga gtggtgttgt agggagtgca ccatgcctcc tctgagcttc     1020

agggccaagg acggttgttg gtacggcatg gagatcaggc ccagaaagga gccagagagc     1080

aacctcgtgc ggtctatggt gacagccgga agctgataa                            1119


<210>  27
<211>  371
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-NS1

<400>  27

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Val Gly Cys Ser Val Asp Phe Ser Lys Lys Glu Thr Arg Cys 
            20                  25                  30          


Gly Thr Gly Val Phe Val Tyr Asn Asp Val Glu Ala Trp Arg Asp Arg 
        35                  40                  45              


Tyr Lys Tyr His Pro Asp Ser Pro Arg Arg Leu Ala Ala Ala Val Lys 
    50                  55                  60                  


Gln Ala Trp Glu Glu Gly Ile Cys Gly Ile Ser Ser Val Ser Arg Met 
65                  70                  75                  80  


Glu Asn Ile Met Trp Lys Ser Val Glu Gly Glu Leu Asn Ala Ile Leu 
                85                  90                  95      


Glu Glu Asn Gly Val Gln Leu Thr Val Val Val Gly Ser Val Lys Asn 
            100                 105                 110         


Pro Met Trp Arg Gly Pro Gln Arg Leu Pro Val Pro Val Asn Glu Leu 
        115                 120                 125             


Pro His Gly Trp Lys Ala Trp Gly Lys Ser Tyr Phe Val Arg Ala Ala 
    130                 135                 140                 


Lys Thr Asn Asn Ser Phe Val Val Asp Gly Asp Thr Leu Lys Glu Cys 
145                 150                 155                 160 


Pro Leu Lys His Arg Ala Trp Asn Ser Phe Leu Val Glu Asp His Gly 
                165                 170                 175     


Phe Gly Val Phe His Thr Ser Val Trp Leu Lys Val Arg Glu Asp Tyr 
            180                 185                 190         


Ser Leu Glu Cys Asp Pro Ala Val Ile Gly Thr Ala Val Lys Gly Lys 
        195                 200                 205             


Glu Ala Ala His Ser Asp Leu Gly Tyr Trp Ile Glu Ser Glu Lys Asn 
    210                 215                 220                 


Asp Thr Trp Arg Leu Lys Arg Ala His Leu Ile Glu Met Lys Thr Cys 
225                 230                 235                 240 


Glu Trp Pro Lys Ser His Thr Leu Trp Thr Asp Gly Val Glu Glu Ser 
                245                 250                 255     


Asp Leu Ile Ile Pro Lys Ser Leu Ala Gly Pro Leu Ser His His Asn 
            260                 265                 270         


Thr Arg Glu Gly Tyr Arg Thr Gln Val Lys Gly Pro Trp His Ser Glu 
        275                 280                 285             


Glu Leu Glu Ile Arg Phe Glu Glu Cys Pro Gly Thr Lys Val His Val 
    290                 295                 300                 


Glu Glu Thr Cys Gly Thr Arg Gly Pro Ser Leu Arg Ser Thr Thr Ala 
305                 310                 315                 320 


Ser Gly Arg Val Ile Glu Glu Trp Cys Cys Arg Glu Cys Thr Met Pro 
                325                 330                 335     


Pro Leu Ser Phe Arg Ala Lys Asp Gly Cys Trp Tyr Gly Met Glu Ile 
            340                 345                 350         


Arg Pro Arg Lys Glu Pro Glu Ser Asn Leu Val Arg Ser Met Val Thr 
        355                 360                 365             


Ala Gly Ser 
    370     


<210>  28
<211>  438
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-capsid

<400>  28
atggactgga cttggatcct gtttctggtg gccgccgcca caagagtgca tagcaagaac       60

cccaagaaga agagcggcgg cttcaggatc gtgaacatgc tgaagcgggg cgtggctaga      120

gtgaaccctc tgggaggcgg actgaagaga ctgccagcag gactgctcct gggacacgga      180

cctattcgca tggtgctggc catcctggct ttcctgaggt tcaccgccat caagcccagc      240

ctgggactga tcaaccgctg gggttcagtc ggcaagaagg aggccatgga gatcatcaag      300

aagttcaaga aggacctggc cgccatgctg aggatcatca acgcccggaa ggagcggaag      360

agaagaggag ccgacaccag catcggcatc atcggactgc tgctgacaac cgccatggct      420

gccgagatct gatgatga                                                    438


<210>  29
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-capsid

<400>  29

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Lys Asn Pro Lys Lys Lys Ser Gly Gly Phe Arg Ile Val Asn 
            20                  25                  30          


Met Leu Lys Arg Gly Val Ala Arg Val Asn Pro Leu Gly Gly Gly Leu 
        35                  40                  45              


Lys Arg Leu Pro Ala Gly Leu Leu Leu Gly His Gly Pro Ile Arg Met 
    50                  55                  60                  


Val Leu Ala Ile Leu Ala Phe Leu Arg Phe Thr Ala Ile Lys Pro Ser 
65                  70                  75                  80  


Leu Gly Leu Ile Asn Arg Trp Gly Ser Val Gly Lys Lys Glu Ala Met 
                85                  90                  95      


Glu Ile Ile Lys Lys Phe Lys Lys Asp Leu Ala Ala Met Leu Arg Ile 
            100                 105                 110         


Ile Asn Ala Arg Lys Glu Arg Lys Arg Arg Gly Ala Asp Thr Ser Ile 
        115                 120                 125             


Gly Ile Ile Gly Leu Leu Leu Thr Thr Ala Met Ala Ala Glu Ile 
    130                 135                 140             


<210>  30
<211>  2130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Zika IgE Leader-prME MR766

<400>  30
atggactgga cttggattct gttcctggtg gctgccgcta caagagtgca ttcaggagcc       60

gacacctcta tcggcatcgt gggactgctg ctgaccacag ccatggccgc cgaaattacc      120

aggaggggca gcgcctacta catgtacctg gacagaagcg acgccggaaa agccatcagc      180

ttcgccacaa ccctgggcgt caacaagtgc cacgtgcaga tcatggacct gggccacatg      240

tgcgacgcca caatgagcta cgagtgccct atgctggacg agggagtgga accagacgac      300

gtcgactgtt ggtgcaacac cacctccact tgggtcgtgt acggcacttg ccaccacaag      360

aagggcgagg ccagaagaag cagaagagcc gtgaccctgc ctagccacag caccagaaag      420

ctgcagacca ggagccagac ttggctggaa agccgcgagt acaccaagca cctgatcaag      480

gtggagaatt ggatcttccg gaaccccggc ttcacactgg tggccgtggc aatcgcttgg      540

ctgctgggat ctagcaccag ccagaaagtg atctacctgg tcatgatcct gctgatcgcc      600

ccagcctaca gcatccgctg tatcggagtg agcaaccggg acttcgtgga gggaatgagc      660

ggaggaactt gggtggacgt ggtgctggaa cacggaggtt gcgtgacagt gatggctcag      720

gacaagccca ccgtggatat cgagctggtg accaccaccg tgtccaacat ggccgaagtg      780

cgcagctact gctacgaggc cagtatctcc gacatggcca gcgatagccg ctgtcctaca      840

cagggagagg cctatctgga caagcagagc gacacccagt acgtctgcaa gaggaccctc      900

gtggatagag gctggggaaa cggttgcgga ctgttcggaa agggcagcct cgtgacttgc      960

gccaagttca cttgcagcaa gaagatgacc ggcaagtcta tccagcccga gaacctggag     1020

taccggatca tgctgagcgt gcacggaagc cagcacagcg gcatgatcgt gaacgacgag     1080

ggatacgaga ccgacgagaa cagggccaag gtggaagtga cccctaacag ccctagagcc     1140

gaagccacac tgggaggatt tggcagcctg ggactggatt gcgagcctag aacaggcctg     1200

gacttcagcg acctgtacta cctgaccatg aacaacaagc attggctggt gcacaaggag     1260

tggttccacg acatccctct gccttggcac gcaggagccg atacaggcac acctcattgg     1320

aacaacaagg aggccctggt ggagttcaag gacgctcacg ccaagagaca gacagtggtg     1380

gtgctgggaa gccaggaagg agcagtgcat acagccctgg caggagctct ggaagcagaa     1440

atggacggcg ctaagggcag actgttcagc ggacacctca agtgccggct gaagatggac     1500

aagctgcggc tgaagggcgt gtcttacagc ctctgcaccg cagccttcac cttcaccaag     1560

gtgccagcag agacactgca cggaacagtg accgtggaag tgcagtacgc cggaacagac     1620

ggaccttgca aagtgccagc ccagatggca gtggacatgc agacactgac cccagtggga     1680

aggctgatca ccgctaaccc cgtcatcacc gagagcaccg agaacagcaa gatgatgctg     1740

gagctggacc cccccttcgg cgatagctac atcgtgatcg gcgtgggcga caagaagatc     1800

acccaccatt ggcacagaag cggcagcaca atcggcaagg ctttcgaggc caccgtgaga     1860

ggagctaaga gaatggccgt gctgggagac accgcttggg attttggcag cgtgggagga     1920

gtgttcaaca gcctgggcaa gggcatccac cagatcttcg gagccgcctt caagagcctg     1980

ttcggcggca tgtcttggtt cagccagatc ctgatcggaa cactcctcgt ctggctggga     2040

ctgaacacca agaacggcag catcagcctg acttgtctgg ccctgggagg cgtgatgatc     2100

ttcctgagca ccgccgtgtc cgcttgataa                                      2130


<210>  31
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Zika IgE Leader-prME MR766

<400>  31

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ala Asp Thr Ser Ile Gly Ile Val Gly Leu Leu Leu Thr 
            20                  25                  30          


Thr Ala Met Ala Ala Glu Ile Thr Arg Arg Gly Ser Ala Tyr Tyr Met 
        35                  40                  45              


Tyr Leu Asp Arg Ser Asp Ala Gly Lys Ala Ile Ser Phe Ala Thr Thr 
    50                  55                  60                  


Leu Gly Val Asn Lys Cys His Val Gln Ile Met Asp Leu Gly His Met 
65                  70                  75                  80  


Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro Met Leu Asp Glu Gly Val 
                85                  90                  95      


Glu Pro Asp Asp Val Asp Cys Trp Cys Asn Thr Thr Ser Thr Trp Val 
            100                 105                 110         


Val Tyr Gly Thr Cys His His Lys Lys Gly Glu Ala Arg Arg Ser Arg 
        115                 120                 125             


Arg Ala Val Thr Leu Pro Ser His Ser Thr Arg Lys Leu Gln Thr Arg 
    130                 135                 140                 


Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr Thr Lys His Leu Ile Lys 
145                 150                 155                 160 


Val Glu Asn Trp Ile Phe Arg Asn Pro Gly Phe Thr Leu Val Ala Val 
                165                 170                 175     


Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr 
            180                 185                 190         


Leu Val Met Ile Leu Leu Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile 
        195                 200                 205             


Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp 
    210                 215                 220                 


Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln 
225                 230                 235                 240 


Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn 
                245                 250                 255     


Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met 
            260                 265                 270         


Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys 
        275                 280                 285             


Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu Val Asp Arg Gly 
    290                 295                 300                 


Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys 
305                 310                 315                 320 


Ala Lys Phe Thr Cys Ser Lys Lys Met Thr Gly Lys Ser Ile Gln Pro 
                325                 330                 335     


Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His 
            340                 345                 350         


Ser Gly Met Ile Val Asn Asp Glu Gly Tyr Glu Thr Asp Glu Asn Arg 
        355                 360                 365             


Ala Lys Val Glu Val Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu 
    370                 375                 380                 


Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu 
385                 390                 395                 400 


Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu 
                405                 410                 415     


Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly 
            420                 425                 430         


Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu 
        435                 440                 445             


Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser 
    450                 455                 460                 


Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu 
465                 470                 475                 480 


Met Asp Gly Ala Lys Gly Arg Leu Phe Ser Gly His Leu Lys Cys Arg 
                485                 490                 495     


Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys 
            500                 505                 510         


Thr Ala Ala Phe Thr Phe Thr Lys Val Pro Ala Glu Thr Leu His Gly 
        515                 520                 525             


Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys 
    530                 535                 540                 


Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly 
545                 550                 555                 560 


Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser 
                565                 570                 575     


Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val 
            580                 585                 590         


Ile Gly Val Gly Asp Lys Lys Ile Thr His His Trp His Arg Ser Gly 
        595                 600                 605             


Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg 
    610                 615                 620                 


Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly 
625                 630                 635                 640 


Val Phe Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala 
                645                 650                 655     


Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile 
            660                 665                 670         


Gly Thr Leu Leu Val Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile 
        675                 680                 685             


Ser Leu Thr Cys Leu Ala Leu Gly Gly Val Met Ile Phe Leu Ser Thr 
    690                 695                 700                 


Ala Val Ser Ala 
705             


<210>  32
<211>  2130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Zika IgE Leader-prME Brazil

<400>  32
atggactgga cttggattct gttcctggtg gctgccgcta caagagtgca ttcaggagcc       60

gacacatcag tgggcatcgt gggactgctg ctgacaacag ctatggccgc cgaagtgacc      120

agaagaggca gcgcctacta catgtacctg gaccggaacg acgccggaga ggccattagc      180

tttcctacca ccctgggcat gaacaagtgc tacatccaga tcatggacct gggccacatg      240

tgcgacgcta caatgagcta cgagtgcccc atgctggacg aaggagtgga gccagacgac      300

gtggattgtt ggtgcaacac cacctccact tgggtcgtgt acggcacctg tcaccacaaa      360

aagggcgaag ccaggagaag cagaagagcc gtgaccctgc ctagccactc taccaggaag      420

ctgcagacca ggagccagac ttggctggag agcagggagt acaccaagca cctgatccgc      480

gtggagaatt ggatcttcag aaaccccggc ttcgccctgg cagccgcagc aattgcttgg      540

ctgctgggat ctagcaccag ccagaaggtc atctacctgg tcatgatcct gctgatcgcc      600

cccgcttaca gcatccgctg tatcggcgtg tccaacaggg acttcgtgga gggcatgagc      660

ggaggaactt gggtggacgt ggtgctggaa cacggaggtt gtgtgaccgt gatggctcag      720

gacaagccta ccgtggacat cgagctggtg accacaaccg tgtccaacat ggccgaggtc      780

cgcagctatt gctacgaggc cagcatcagc gatatggcca gcgatagcag gtgtcccacc      840

cagggtgaag cttacctgga caagcagagc gacacccagt acgtgtgcaa gcggacactg      900

gtggatagag gctggggaaa cggttgcggc ctgtttggca agggaagcct ggtgacctgc      960

gccaagttcg catgcagcaa gaagatgacc ggcaagagca tccagcccga gaacctggag     1020

taccggatca tgctgagcgt gcacggatct cagcatagcg gaatgatcgt gaacgacacc     1080

ggccacgaga ccgacgaaaa cagggccaag gtggaaatca cccccaactc tcctagagcc     1140

gaggccacac tgggaggttt tggaagcctg ggcctggatt gcgagcctag aacaggcctg     1200

gacttcagcg acctgtacta cctgaccatg aacaacaagc attggctggt gcacaaggag     1260

tggttccacg acatccctct gccttggcac gcaggagcag atacaggaac cccccattgg     1320

aacaacaagg aggccctggt ggagttcaag gacgctcacg ccaagagaca gacagtggtg     1380

gtgctgggaa gccaggaagg agcagtgcac acagctctgg caggagctct ggaagccgaa     1440

atggacggag ccaagggcag actgtcctcc ggacacctca agtgccggct gaagatggac     1500

aagctgcggc tgaagggcgt gtcttatagc ctctgcacag ccgctttcac cttcaccaag     1560

atccccgcag agaccctgca cggaacagtg accgtggaag tgcagtacgc cggaacagac     1620

ggaccttgca aggtgccagc tcagatggca gtggacatgc agaccctgac cccagtggga     1680

agactgatca ccgctaaccc cgtcatcacc gagagcaccg agaacagcaa gatgatgctg     1740

gagctggacc cccccttcgg cgatagctac atcgtgatcg gcgtgggcga gaaaaagatc     1800

acccaccatt ggcacaggag cggcagcaca atcggcaagg cctttgaggc caccgtgaga     1860

ggagccaaga gaatggccgt gctgggagat accgcttggg atttcggcag cgtgggaggc     1920

gccctgaaca gcctgggcaa gggcattcac cagatcttcg gagccgcctt caagagcctg     1980

ttcggcggca tgtcttggtt cagccagatc ctgatcggca cactgctcat gtggctgggc     2040

ctgaacacca agaacggcag catcagcctg atgtgtctgg ctctgggagg cgtgctgatc     2100

ttcctgagca ccgctgtgtc cgcttgataa                                      2130


<210>  33
<211>  708
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Zika IgE Leader-prME Brazil

<400>  33

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ala Asp Thr Ser Val Gly Ile Val Gly Leu Leu Leu Thr 
            20                  25                  30          


Thr Ala Met Ala Ala Glu Val Thr Arg Arg Gly Ser Ala Tyr Tyr Met 
        35                  40                  45              


Tyr Leu Asp Arg Asn Asp Ala Gly Glu Ala Ile Ser Phe Pro Thr Thr 
    50                  55                  60                  


Leu Gly Met Asn Lys Cys Tyr Ile Gln Ile Met Asp Leu Gly His Met 
65                  70                  75                  80  


Cys Asp Ala Thr Met Ser Tyr Glu Cys Pro Met Leu Asp Glu Gly Val 
                85                  90                  95      


Glu Pro Asp Asp Val Asp Cys Trp Cys Asn Thr Thr Ser Thr Trp Val 
            100                 105                 110         


Val Tyr Gly Thr Cys His His Lys Lys Gly Glu Ala Arg Arg Ser Arg 
        115                 120                 125             


Arg Ala Val Thr Leu Pro Ser His Ser Thr Arg Lys Leu Gln Thr Arg 
    130                 135                 140                 


Ser Gln Thr Trp Leu Glu Ser Arg Glu Tyr Thr Lys His Leu Ile Arg 
145                 150                 155                 160 


Val Glu Asn Trp Ile Phe Arg Asn Pro Gly Phe Ala Leu Ala Ala Ala 
                165                 170                 175     


Ala Ile Ala Trp Leu Leu Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr 
            180                 185                 190         


Leu Val Met Ile Leu Leu Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile 
        195                 200                 205             


Gly Val Ser Asn Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp 
    210                 215                 220                 


Val Asp Val Val Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln 
225                 230                 235                 240 


Asp Lys Pro Thr Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn 
                245                 250                 255     


Met Ala Glu Val Arg Ser Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met 
            260                 265                 270         


Ala Ser Asp Ser Arg Cys Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys 
        275                 280                 285             


Gln Ser Asp Thr Gln Tyr Val Cys Lys Arg Thr Leu Val Asp Arg Gly 
    290                 295                 300                 


Trp Gly Asn Gly Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys 
305                 310                 315                 320 


Ala Lys Phe Ala Cys Ser Lys Lys Met Thr Gly Lys Ser Ile Gln Pro 
                325                 330                 335     


Glu Asn Leu Glu Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His 
            340                 345                 350         


Ser Gly Met Ile Val Asn Asp Thr Gly His Glu Thr Asp Glu Asn Arg 
        355                 360                 365             


Ala Lys Val Glu Ile Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu 
    370                 375                 380                 


Gly Gly Phe Gly Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu 
385                 390                 395                 400 


Asp Phe Ser Asp Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu 
                405                 410                 415     


Val His Lys Glu Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly 
            420                 425                 430         


Ala Asp Thr Gly Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu 
        435                 440                 445             


Phe Lys Asp Ala His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser 
    450                 455                 460                 


Gln Glu Gly Ala Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu 
465                 470                 475                 480 


Met Asp Gly Ala Lys Gly Arg Leu Ser Ser Gly His Leu Lys Cys Arg 
                485                 490                 495     


Leu Lys Met Asp Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys 
            500                 505                 510         


Thr Ala Ala Phe Thr Phe Thr Lys Ile Pro Ala Glu Thr Leu His Gly 
        515                 520                 525             


Thr Val Thr Val Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys 
    530                 535                 540                 


Val Pro Ala Gln Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly 
545                 550                 555                 560 


Arg Leu Ile Thr Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser 
                565                 570                 575     


Lys Met Met Leu Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val 
            580                 585                 590         


Ile Gly Val Gly Glu Lys Lys Ile Thr His His Trp His Arg Ser Gly 
        595                 600                 605             


Ser Thr Ile Gly Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg 
    610                 615                 620                 


Met Ala Val Leu Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly 
625                 630                 635                 640 


Ala Leu Asn Ser Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala 
                645                 650                 655     


Phe Lys Ser Leu Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile 
            660                 665                 670         


Gly Thr Leu Leu Met Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile 
        675                 680                 685             


Ser Leu Met Cys Leu Ala Leu Gly Gly Val Leu Ile Phe Leu Ser Thr 
    690                 695                 700                 


Ala Val Ser Ala 
705             


<210>  34
<211>  1119
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-NS1 DNA (pGX7211)

<400>  34
atggactgga cctggattct gttcctggtg gcagcagcaa cacgggtgca ctccgtgggc       60

tgctctgtgg atttcagcaa gaaggagaca agatgtggca caggcgtgtt cgtgtacaac      120

gacgtggagg cctggaggga tcgctacaag tatcaccctg actctccacg gagactggca      180

gcagcagtga agcaggcatg ggaggagggc atctgcggca tcagctccgt gtcccggatg      240

gagaatatca tgtggaagtc tgtggagggc gagctgaacg ccatcctgga ggagaatgga      300

gtgcagctga ccgtggtggt gggcagcgtg aagaacccaa tgtggagggg accacagaga      360

ctgccagtgc cagtgaatga gctgccacac ggatggaagg catggggcaa gtcttatttc      420

gtgagggccg ccaagaccaa caatagcttt gtggtggacg gcgatacact gaaggagtgc      480

cccctgaagc accgcgcctg gaactccttt ctggtggagg atcacggctt cggcgtgttt      540

cacaccagcg tgtggctgaa ggtgagggag gactactccc tggagtgtga tcctgccgtg      600

atcggaacag cagtgaaggg caaggaggca gcacactctg acctgggcta ttggatcgag      660

agcgagaaga acgatacctg gaggctgaag cgcgcccacc tgatcgagat gaagacctgt      720

gagtggccaa agtcccacac cctgtggaca gacggcgtgg aggagtctga tctgatcatc      780

cctaagagcc tggccggccc actgtcccac cacaatacca gggagggcta ccgcacacag      840

gtgaagggcc cctggcactc cgaggagctg gagatccgct tcgaggagtg ccctggcacc      900

aaggtgcacg tggaggagac atgtggcaca cggggcccct ctctgagaag caccacagcc      960

agcggcagag tgatcgagga gtggtgctgt cgcgagtgca caatgccccc tctgtccttt     1020

cgggccaagg acggctgttg gtatggcatg gagatccggc ccagaaagga gcctgagtcc     1080

aatctggtga gatctatggt gaccgccggc agctgataa                            1119


<210>  35
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  consensus Zika IgE Leader-capsid DNA (pGX7212)

<400>  35
atggactgga cctggattct gttcctggtg gcagcagcaa cacgggtgca cagcaagaac       60

cccaagaaga agagcggcgg cttccggatc gtgaacatgc tgaagcgggg cgtggccaga      120

gtgaatccac tgggcggcgg cctgaagcgg ctgcctgcag gcctgctgct gggccacggc      180

ccaatcagga tggtgctggc catcctggcc ttcctgcgct ttaccgccat caagccctct      240

ctgggcctga tcaacagatg gggcagcgtg ggcaagaagg aggccatgga gatcatcaag      300

aagttcaaga aggacctggc cgccatgctg cgcatcatca atgcaaggaa ggagaggaag      360

aggagaggcg ccgatacaag catcggcatc atcggcctgc tgctgaccac agcaatggca      420

gccgagatct gataa                                                       435


<210>  36
<211>  2130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Zika IgE Leader-prME Brazil DNA (pGX7213)

<400>  36
atggactgga cctggattct gttcctggtg gcagcagcaa cacgggtgca cagcggagca       60

gatacctccg tgggaatcgt gggcctgctg ctgaccacag caatggcagc agaggtgacc      120

aggagaggct ctgcctacta tatgtacctg gacagaaatg atgccggcga ggccatcagc      180

ttccccacca cactgggcat gaacaagtgc tacatccaga tcatggacct gggccacatg      240

tgcgatgcca ccatgagcta tgagtgtcca atgctggacg agggcgtgga gcccgacgat      300

gtggattgct ggtgtaatac cacatccaca tgggtggtgt acggcacctg tcaccacaag      360

aagggagagg caaggcgctc tcggagagca gtgacactgc cttcccactc tacccggaag      420

ctgcagacaa gatctcagac ctggctggag agccgggagt atacaaagca cctgatccgg      480

gtggagaact ggatctttag aaatccagga ttcgcactgg cagcagcagc aatcgcctgg      540

ctgctgggca gctccacctc tcagaaagtg atctacctgg tcatgatcct gctgatcgcc      600

cctgcctatt ccatcaggtg catcggcgtg tctaatcgcg actttgtgga gggaatgtcc      660

ggcggcacct gggtggatgt ggtgctggag cacggcggat gcgtgacagt gatggcccag      720

gacaagccaa ccgtggatat cgagctggtg accacaaccg tgagcaacat ggccgaggtg      780

cggtcctact gctatgaggc cagcatctcc gacatggcct ctgatagcag atgtcccacc      840

cagggcgagg cctacctgga caagcagagc gatacacagt acgtgtgcaa gaggaccctg      900

gtggacaggg gatggggaaa tggatgtggc ctgtttggca agggctccct ggtgacatgc      960

gccaagttcg cctgttctaa gaagatgacc ggcaagagca tccagccaga gaacctggag     1020

taccggatca tgctgagcgt gcacggctcc cagcactctg gcatgatcgt gaacgacaca     1080

ggccacgaga cagatgagaa tagggccaag gtggagatca cacctaacag cccacgcgcc     1140

gaggccaccc tgggcggctt tggctccctg ggcctggact gcgagcctag aacaggcctg     1200

gacttctccg atctgtacta tctgaccatg aacaataagc actggctggt gcacaaggag     1260

tggtttcacg acatcccact gccatggcac gcaggagcag atacaggaac cccacactgg     1320

aacaataagg aggccctggt ggagttcaag gatgcccacg ccaagaggca gacagtggtg     1380

gtgctgggca gccaggaggg agcagtgcac accgccctgg caggcgccct ggaggccgag     1440

atggacggag caaagggccg cctgtctagc ggccacctga agtgccggct gaagatggat     1500

aagctgagac tgaagggcgt gtcctactct ctgtgcacag ccgccttcac cttcaccaag     1560

atccctgccg agacactgca cggcacagtg accgtggagg tgcagtatgc cggcacagac     1620

ggcccctgta aggtgcctgc ccagatggcc gtggatatgc agacactgac ccctgtgggc     1680

aggctgatca ccgccaatcc agtgatcaca gagtctaccg agaacagcaa gatgatgctg     1740

gagctggacc ctcccttcgg cgacagctat atcgtgatcg gcgtgggcga gaagaagatc     1800

acacaccact ggcaccgcag cggctccaca atcggcaagg cctttgaggc caccgtgagg     1860

ggcgccaaga ggatggccgt gctgggcgac accgcatggg atttcggctc cgtgggcggc     1920

gccctgaact ctctgggcaa gggcatccac cagatcttcg gcgccgcctt taagtccctg     1980

ttcggcggaa tgagctggtt ttcccagatc ctgatcggca cactgctgat gtggctgggc     2040

ctgaacacca agaatggctc tatcagcctg atgtgcctgg ccctgggcgg cgtgctgatc     2100

ttcctgtcca ccgccgtgtc tgcctgataa                                      2130


<210>  37
<211>  2130
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Zika IgE Leader-prME MR766 DNA (pGX7214)

<400>  37
atggactgga cctggattct gttcctggtg gcagcagcaa cacgggtgca ctccggagcc       60

gatacctcta tcggcatcgt gggcctgctg ctgaccacag caatggcagc agagatcacc      120

aggagaggca gcgcctacta tatgtacctg gacagatctg atgccggcaa ggccatcagc      180

ttcgccacca cactgggcgt gaataagtgc cacgtgcaga tcatggacct gggccacatg      240

tgcgatgcca ccatgtccta cgagtgtcca atgctggacg agggcgtgga gcccgacgat      300

gtggattgct ggtgtaacac cacatctaca tgggtggtgt atggcacctg tcaccacaag      360

aagggagagg caaggcgcag ccggagagca gtgacactgc cctctcacag cacccggaag      420

ctgcagacaa gaagccagac ctggctggag tccagggagt ataccaagca cctgatcaag      480

gtggagaact ggatctttcg caatcccggc ttcacactgg tggcagtggc aatcgcatgg      540

ctgctgggca gctccacctc tcagaaagtg atctacctgg tcatgatcct gctgatcgcc      600

cctgcctatt ccatccggtg catcggcgtg tctaatagag actttgtgga gggaatgtcc      660

ggcggcacct gggtggatgt ggtgctggag cacggcggat gcgtgacagt gatggcccag      720

gacaagccaa ccgtggatat cgagctggtg accacaaccg tgagcaacat ggccgaggtg      780

cggtcctact gctatgaggc ctccatctct gacatggcca gcgattccag atgtcccacc      840

cagggcgagg cctacctgga caagcagtcc gatacacagt acgtgtgcaa gaggaccctg      900

gtggacaggg gatggggaaa tggatgtggc ctgtttggca agggctctct ggtgacatgc      960

gccaagttca cctgttctaa gaagatgaca ggcaagagca tccagcccga gaacctggag     1020

taccggatca tgctgagcgt gcacggctct cagcacagcg gcatgatcgt gaacgacgag     1080

ggctatgaga cagatgagaa tcgggccaag gtggaggtga cacctaacag cccaagagcc     1140

gaggccaccc tgggcggctt tggctccctg ggcctggact gcgagcctag gacaggcctg     1200

gacttctccg atctgtacta tctgaccatg aacaataagc actggctggt gcacaaggag     1260

tggtttcacg acatcccact gccatggcac gcaggagcag atacaggaac cccacactgg     1320

aacaataagg aggccctggt ggagttcaag gatgcccacg ccaagaggca gacagtggtg     1380

gtgctgggca gccaggaggg agcagtgcac accgccctgg caggcgccct ggaggccgag     1440

atggacggag caaagggccg cctgttctcc ggccacctga agtgcaggct gaagatggat     1500

aagctgcgcc tgaagggcgt gtcttacagc ctgtgcacag ccgccttcac cttcaccaag     1560

gtgcctgccg agacactgca cggcacagtg accgtggagg tgcagtatgc cggcacagac     1620

ggcccctgta aggtgcctgc ccagatggcc gtggatatgc agacactgac ccctgtgggc     1680

aggctgatca ccgccaatcc agtgatcaca gagagcaccg agaactccaa gatgatgctg     1740

gagctggacc ctcccttcgg cgacagctac atcgtgatcg gcgtgggcga caagaagatc     1800

acacaccact ggcaccgctc cggctctaca atcggcaagg ccttcgaggc caccgtgagg     1860

ggcgccaaga ggatggccgt gctgggcgac accgcatggg attttggctc cgtgggcggc     1920

gtgttcaatt ctctgggcaa gggcatccac cagatcttcg gcgccgcctt taagagcctg     1980

ttcggcggaa tgtcctggtt ttctcagatc ctgatcggca cactgctggt gtggctgggc     2040

ctgaacacaa agaatggcag catctccctg acctgcctgg ccctgggcgg cgtgatgatc     2100

ttcctgtcta ccgccgtgag cgcctgataa                                      2130


<210>  38
<211>  2070
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Zika PreEnv (MR766) w/out capsid DNA (pGX7210)

<400>  38
atggactgga cttggattct gttcctggtg gctgccgcta caagagtgca ttcaattacc       60

aggaggggca gcgcctacta catgtacctg gacagaagcg acgccggaaa agccatcagc      120

ttcgccacaa ccctgggcgt caacaagtgc cacgtgcaga tcatggacct gggccacatg      180

tgcgacgcca caatgagcta cgagtgccct atgctggacg agggagtgga accagacgac      240

gtcgactgtt ggtgcaacac cacctccact tgggtcgtgt acggcacttg ccaccacaag      300

aagggcgagg ccagaagaag cagaagagcc gtgaccctgc ctagccacag caccagaaag      360

ctgcagacca ggagccagac ttggctggaa agccgcgagt acaccaagca cctgatcaag      420

gtggagaatt ggatcttccg gaaccccggc ttcacactgg tggccgtggc aatcgcttgg      480

ctgctgggat ctagcaccag ccagaaagtg atctacctgg tcatgatcct gctgatcgcc      540

ccagcctaca gcatccgctg tatcggagtg agcaaccggg acttcgtgga gggaatgagc      600

ggaggaactt gggtggacgt ggtgctggaa cacggaggtt gcgtgacagt gatggctcag      660

gacaagccca ccgtggatat cgagctggtg accaccaccg tgtccaacat ggccgaagtg      720

cgcagctact gctacgaggc cagtatctcc gacatggcca gcgatagccg ctgtcctaca      780

cagggagagg cctatctgga caagcagagc gacacccagt acgtctgcaa gaggaccctc      840

gtggatagag gctggggaaa cggttgcgga ctgttcggaa agggcagcct cgtgacttgc      900

gccaagttca cttgcagcaa gaagatgacc ggcaagtcta tccagcccga gaacctggag      960

taccggatca tgctgagcgt gcacggaagc cagcacagcg gcatgatcgt gaacgacgag     1020

ggatacgaga ccgacgagaa cagggccaag gtggaagtga cccctaacag ccctagagcc     1080

gaagccacac tgggaggatt tggcagcctg ggactggatt gcgagcctag aacaggcctg     1140

gacttcagcg acctgtacta cctgaccatg aacaacaagc attggctggt gcacaaggag     1200

tggttccacg acatccctct gccttggcac gcaggagccg atacaggcac acctcattgg     1260

aacaacaagg aggccctggt ggagttcaag gacgctcacg ccaagagaca gacagtggtg     1320

gtgctgggaa gccaggaagg agcagtgcat acagccctgg caggagctct ggaagcagaa     1380

atggacggcg ctaagggcag actgttcagc ggacacctca agtgccggct gaagatggac     1440

aagctgcggc tgaagggcgt gtcttacagc ctctgcaccg cagccttcac cttcaccaag     1500

gtgccagcag agacactgca cggaacagtg accgtggaag tgcagtacgc cggaacagac     1560

ggaccttgca aagtgccagc ccagatggca gtggacatgc agacactgac cccagtggga     1620

aggctgatca ccgctaaccc cgtcatcacc gagagcaccg agaacagcaa gatgatgctg     1680

gagctggacc cccccttcgg cgatagctac atcgtgatcg gcgtgggcga caagaagatc     1740

acccaccatt ggcacagaag cggcagcaca atcggcaagg ctttcgaggc caccgtgaga     1800

ggagctaaga gaatggccgt gctgggagac accgcttggg attttggcag cgtgggagga     1860

gtgttcaaca gcctgggcaa gggcatccac cagatcttcg gagccgcctt caagagcctg     1920

ttcggcggca tgtcttggtt cagccagatc ctgatcggaa cactcctcgt ctggctggga     1980

ctgaacacca agaacggcag catcagcctg acttgtctgg ccctgggagg cgtgatgatc     2040

ttcctgagca ccgccgtgtc cgcttgataa                                      2070


<210>  39
<211>  688
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Zika PreEnv (MR766) w/out capsid Protein (pGX7210)

<400>  39

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Ile Thr Arg Arg Gly Ser Ala Tyr Tyr Met Tyr Leu Asp Arg 
            20                  25                  30          


Ser Asp Ala Gly Lys Ala Ile Ser Phe Ala Thr Thr Leu Gly Val Asn 
        35                  40                  45              


Lys Cys His Val Gln Ile Met Asp Leu Gly His Met Cys Asp Ala Thr 
    50                  55                  60                  


Met Ser Tyr Glu Cys Pro Met Leu Asp Glu Gly Val Glu Pro Asp Asp 
65                  70                  75                  80  


Val Asp Cys Trp Cys Asn Thr Thr Ser Thr Trp Val Val Tyr Gly Thr 
                85                  90                  95      


Cys His His Lys Lys Gly Glu Ala Arg Arg Ser Arg Arg Ala Val Thr 
            100                 105                 110         


Leu Pro Ser His Ser Thr Arg Lys Leu Gln Thr Arg Ser Gln Thr Trp 
        115                 120                 125             


Leu Glu Ser Arg Glu Tyr Thr Lys His Leu Ile Lys Val Glu Asn Trp 
    130                 135                 140                 


Ile Phe Arg Asn Pro Gly Phe Thr Leu Val Ala Val Ala Ile Ala Trp 
145                 150                 155                 160 


Leu Leu Gly Ser Ser Thr Ser Gln Lys Val Ile Tyr Leu Val Met Ile 
                165                 170                 175     


Leu Leu Ile Ala Pro Ala Tyr Ser Ile Arg Cys Ile Gly Val Ser Asn 
            180                 185                 190         


Arg Asp Phe Val Glu Gly Met Ser Gly Gly Thr Trp Val Asp Val Val 
        195                 200                 205             


Leu Glu His Gly Gly Cys Val Thr Val Met Ala Gln Asp Lys Pro Thr 
    210                 215                 220                 


Val Asp Ile Glu Leu Val Thr Thr Thr Val Ser Asn Met Ala Glu Val 
225                 230                 235                 240 


Arg Ser Tyr Cys Tyr Glu Ala Ser Ile Ser Asp Met Ala Ser Asp Ser 
                245                 250                 255     


Arg Cys Pro Thr Gln Gly Glu Ala Tyr Leu Asp Lys Gln Ser Asp Thr 
            260                 265                 270         


Gln Tyr Val Cys Lys Arg Thr Leu Val Asp Arg Gly Trp Gly Asn Gly 
        275                 280                 285             


Cys Gly Leu Phe Gly Lys Gly Ser Leu Val Thr Cys Ala Lys Phe Thr 
    290                 295                 300                 


Cys Ser Lys Lys Met Thr Gly Lys Ser Ile Gln Pro Glu Asn Leu Glu 
305                 310                 315                 320 


Tyr Arg Ile Met Leu Ser Val His Gly Ser Gln His Ser Gly Met Ile 
                325                 330                 335     


Val Asn Asp Glu Gly Tyr Glu Thr Asp Glu Asn Arg Ala Lys Val Glu 
            340                 345                 350         


Val Thr Pro Asn Ser Pro Arg Ala Glu Ala Thr Leu Gly Gly Phe Gly 
        355                 360                 365             


Ser Leu Gly Leu Asp Cys Glu Pro Arg Thr Gly Leu Asp Phe Ser Asp 
    370                 375                 380                 


Leu Tyr Tyr Leu Thr Met Asn Asn Lys His Trp Leu Val His Lys Glu 
385                 390                 395                 400 


Trp Phe His Asp Ile Pro Leu Pro Trp His Ala Gly Ala Asp Thr Gly 
                405                 410                 415     


Thr Pro His Trp Asn Asn Lys Glu Ala Leu Val Glu Phe Lys Asp Ala 
            420                 425                 430         


His Ala Lys Arg Gln Thr Val Val Val Leu Gly Ser Gln Glu Gly Ala 
        435                 440                 445             


Val His Thr Ala Leu Ala Gly Ala Leu Glu Ala Glu Met Asp Gly Ala 
    450                 455                 460                 


Lys Gly Arg Leu Phe Ser Gly His Leu Lys Cys Arg Leu Lys Met Asp 
465                 470                 475                 480 


Lys Leu Arg Leu Lys Gly Val Ser Tyr Ser Leu Cys Thr Ala Ala Phe 
                485                 490                 495     


Thr Phe Thr Lys Val Pro Ala Glu Thr Leu His Gly Thr Val Thr Val 
            500                 505                 510         


Glu Val Gln Tyr Ala Gly Thr Asp Gly Pro Cys Lys Val Pro Ala Gln 
        515                 520                 525             


Met Ala Val Asp Met Gln Thr Leu Thr Pro Val Gly Arg Leu Ile Thr 
    530                 535                 540                 


Ala Asn Pro Val Ile Thr Glu Ser Thr Glu Asn Ser Lys Met Met Leu 
545                 550                 555                 560 


Glu Leu Asp Pro Pro Phe Gly Asp Ser Tyr Ile Val Ile Gly Val Gly 
                565                 570                 575     


Asp Lys Lys Ile Thr His His Trp His Arg Ser Gly Ser Thr Ile Gly 
            580                 585                 590         


Lys Ala Phe Glu Ala Thr Val Arg Gly Ala Lys Arg Met Ala Val Leu 
        595                 600                 605             


Gly Asp Thr Ala Trp Asp Phe Gly Ser Val Gly Gly Val Phe Asn Ser 
    610                 615                 620                 


Leu Gly Lys Gly Ile His Gln Ile Phe Gly Ala Ala Phe Lys Ser Leu 
625                 630                 635                 640 


Phe Gly Gly Met Ser Trp Phe Ser Gln Ile Leu Ile Gly Thr Leu Leu 
                645                 650                 655     


Val Trp Leu Gly Leu Asn Thr Lys Asn Gly Ser Ile Ser Leu Thr Cys 
            660                 665                 670         


Leu Ala Leu Gly Gly Val Met Ile Phe Leu Ser Thr Ala Val Ser Ala 
        675                 680                 685             


<210>  40
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE Leader

<400>  40

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


