                         SEQUENCE LISTING

<110>  Evolva SA
       JULIEN, Bryan
       BURLINGAME, Richard
       WARREN, Craig
 
<120>  PRODUCTION OF SESQUITERPENE PRODUCTS AND RELATED MOLECULES

<130>  16-655-WO

<150>  US 62/396,804
<151>  2016-09-19

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1086
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized EIZS gene

<400>  1
atgcacgcct tcccacatgg tactactgct actccaactg ctattgctgt tccaccatct       60

ttgagattgc cagttattga agctgctttc ccaagacaat tgcatccata ttggccaaag      120

ttgcaagaaa ctactagaac ctggttgttg gaaaaaagat tgatgccagc tgataaggtt      180

gaagaatatg ctgatggttt gtgctacact gatttgatgg ctggttatta cttgggtgct      240

ccagatgaag ttttacaagc tattgcagat tactctgcct ggttttttgt ttgggatgat      300

agacacgata gagatatcgt tcatggtaga gctggtgctt ggagaagatt gagaggtttg      360

ttgcatactg ctttggattc tccaggtgat cacttgcatc atgaagatac tttggttgct      420

ggtttcgctg attccgttag aagattatat gctttcttgc cagctacttg gaatgctaga      480

tttgctagac atttccacac tgttatcgaa gcttacgaca gagaattcca taacagaact      540

agaggtatag ttccaggtgt cgaagaatat ttggaattga gaagattaac cttcgcccat      600

tggatttgga ctgatttgtt ggaaccatct tctggttgtg aattgccaga tgctgttaga      660

aaacatccag cttatagaag agctgccttg ttgtctcaag aatttgctgc ttggtacaac      720

gatttgtgct ctttgccaaa agaaattgcc ggtgatgaag ttcacaactt gggtatttct      780

ttgatcaccc atcattcctt gactttggaa gaagctattg gtgaagttag aagaagagta      840

gaagaatgca tcaccgaatt cttggctgtt gaaagagatg cattgagatt cgctgatgaa      900

ttggctgatg gtactgttag aggtaaagaa ttgtctggtg cagttagagc taatgtcggt      960

aatatgagaa actggttctc ttccgtttac tggttccatc atgaatccgg tagatatatg     1020

gttgattctt gggatgacag atctactcca ccatacgtta acaatgaagc agctggtgaa     1080

aagtaa                                                                1086


<210>  2
<211>  1674
<212>  DNA
<213>  Arabidopsis thaliana

<400>  2
atggaagcat taggaaactt tgattacgaa agctacacca attttacaaa attgccatcc       60

tcccaatggg gtgatcagtt cctcaagttt tccattgctg attcggattt tgatgtcctt      120

gaaagagaga ttgaagtact aaagcctaaa gtaagagaga acatattcgt gtcgtcttcc      180

acagacaaag acgcgatgaa aaagacaatt ctttctattc attttctgga cagtcttggt      240

ctctcttatc attttgagaa ggaaatcgaa gagagcctaa aacatgcttt cgagaagata      300

gaagatttga tcgctgatga aaataaattg cacacaatct ccaccatctt ccgagttttc      360

aggacatacg gttactacat gtcttcggat gttttcaaga tattcaaagg agacgatggt      420

aaattcaagg aaagtttaat agaagatgtc aagggtatgc taagcttcta cgaagcagtg      480

cactatggga caacgacaga tcatatattg gatgaagctt taagcttcac attgaaccac      540

ttggagtcac tagctacagg tcgtagagca agcccaccac atatttcaaa gcttatacaa      600

aatgctcttc acatacctca gcaccgaaac atccaagcgt tggttgcaag ggagtatatc      660

tcgttctatg aacacgaaga ggaccacgac gaaacacttc tcaagctagc taagctcaat      720

ttcaagttct tgcagcttca ttacttccaa gaattaaaaa ccatcacaat gtggtggacg      780

aaattagacc atacatcaaa ccttccacca aacttcagag agagaactgt agagacatgg      840

tttgcagcat tgatgatgta cttcgagcca caattttcac ttgggagaat tatgtcggct      900

aagttatact tagtaataac atttctagac gacgcttgcg atacttatgg ttcaatttct      960

gaagttgaaa gcctggccga ttgtttggaa agatgggatc cagattacat ggaaaatctt     1020

caaggtcaca tgaagactgc cttcaaattt gtgatgtatc tttttaaaga gtatgaagaa     1080

atactaaggt cacaaggaag atcctttgtg ttggagaaaa tgatagaaga gttcaagatt     1140

attgctagga aaaacctcga acttgtcaaa tgggcacgtg gaggtcatgt tcctagcttt     1200

gatgagtata tagagtctgg tggagccgag attggtacat atgcaaccat agcatgttcc     1260

atcatgggac ttggagagat tggtaagaag gaagcttttg agtggctaat atctagacca     1320

aagctcgttc ggattttagg tgcaaagacc cgtctcatgg atgacatagc cgactttgag     1380

gaggacatgg aaaaaggtta cactgcaaat gcactcaact attacatgaa cgaacacgga     1440

gttacaaaag aagaagccag tagagaactt gaaaagatga atggagatat gaacaagatc     1500

gtaaacgaag aatgcttgaa gataactacc atgccacgcc gaattcttat gcaatccgtc     1560

aattatgcac gttcattgga tgttctctat accgcggatg atgtttacaa ccaccgcgaa     1620

ggaaaactca aagagtatat gaggcttttg ctcgtagatc ctatacttct ttag           1674


<210>  3
<211>  1674
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized At5g44630 gene

<400>  3
atggaagctt tgggtaactt cgactacgaa tcttacacta acttcaccaa gttgccatct       60

tctcaatggg gtgatcaatt cttgaagttc tccattgctg attccgattt cgatgtcttg      120

gaaagagaaa tcgaagtctt gaagccaaag gtcagagaaa acatcttcgt ttcttcatcc      180

actgataagg acgctatgaa gaaaaccatc ttgtccatcc atttcttgga ctcattgggt      240

ttgtcttacc acttcgaaaa agaaattgaa gaatccttga agcacgcctt cgaaaagatt      300

gaagatttga ttgctgacga aaacaagttg cataccatct ccactatctt cagagttttc      360

agaacttacg gttactacat gtcctccgat gttttcaaga ttttcaaggg tgatgacggt      420

aaattcaaag aatcattgat cgaagatgtc aagggtatgt tgtctttcta cgaagctgtt      480

cattacggta ctaccaccga tcatattttg gatgaagctt tgtctttcac cttgaaccac      540

ttggaatctt tggctactgg tagaagagct tctccaccac atatttccaa gttgattcaa      600

aacgccttgc atatcccaca acacagaaat attcaagctt tggttgccag agaatatatc      660

tcattctacg aacacgaaga agatcacgac gaaactttgt tgaaattggc caagttgaat      720

ttcaagttct tgcaattaca ctacttccaa gaattgaaaa ccattaccat gtggtggacc      780

aagttggatc atacttctaa tttgccacca aacttcagag aaagaactgt tgaaacttgg      840

tttgctgcct tgatgatgta cttcgaacca caattttctt tgggtagaat catgtccgct      900

aagttgtact tggttatcac cttcttggat gatgcttgtg atacctacgg ttccatttct      960

gaagttgaat ctttagccga ctgtttggaa agatgggatc cagattatat ggaaaacttg     1020

caaggtcata tgaagaccgc ctttaagttc gttatgtact tgtttaaaga atacgaagaa     1080

atcttgagat cccaaggtag atccttcgtt ttggaaaaga tgatagaaga attcaagatt     1140

atcgccagaa agaatttgga attggttaag tgggctagag gtggtcatgt tccatctttc     1200

gatgaatata ttgaatccgg tggtgccgaa attggtactt atgctactat tgcttgctcc     1260

attatgggtt tgggtgaaat cggtaagaaa gaagctttcg aatggttgat ctctagacca     1320

aagttggtta gaattttggg tgctaagacc agattgatgg atgatattgc cgactttgaa     1380

gaagatatgg aaaagggtta taccgctaac gctttgaact actacatgaa cgaacatggt     1440

gtcaccaaag aagaagcttc aagagaattg gaaaaaatga acggtgacat gaacaagatc     1500

gtcaacgaag aatgcttaaa gattaccacc atgcctagaa gaatcttgat gcaatctgtt     1560

aactacgcca gatctttgga tgtcttgtat actgctgatg atgtttacaa ccacagagaa     1620

ggtaaattga aagaatatat gagattgttg ttggtcgacc caattttgtt gtaa           1674


<210>  4
<211>  1743
<212>  DNA
<213>  Pinus sylvestris

<400>  4
atggctcaaa tttctatagg tgcaccacta tctgccgagg tgaacggagc ctgcatcaac       60

actcatcatc atggaaatct gtgggacgac tatttcatac aatctcttaa gtcgccttat      120

gaggcacctg aatgccatga acgctgtgaa aagatgattg aagaagtgaa gcatttactt      180

ttgagtgaga tgagagatgg caacgatgat ttaatcaaac gtctccagat ggttgacatt      240

tttgaatgtc taggaattga tcggcacttt caccatgaaa tacaagctgc tcttgattac      300

gtgtacagat attggaacga gctggaaggc atcggtgttg gaacaagaga ttccctcacc      360

aaagatctgt atgctaccgg tttgggattt cgggctctcc gactccatcg atataatgta      420

tcctcagctg tcttggagaa tttcaagaac gaaaatgggc tgttcttcca cagttccgcg      480

gttcaagaag aagaagtgag atgcatgttg acgttactta gggcttcaga aatttcattt      540

cccggagaaa aggtgatgga cgaggcaaag gcattcgcaa cagaatatct aaaccaactt      600

ttgacgagag tggatataac ggaagtgggt gaaaacctct taagagaggt taggtatgcc      660

ctagattttc cttggtactg cagtgtgccg agatgggagg ctaggagctt catcgaaata      720

tttggacaaa acaattcatg gcttaagtca actatgaaca aaaaagtttt agagttggct      780

aaattggact tcaatattct gcaatccgca catcaaagag agctacagct tctctcaagg      840

tggtggtcac aatcggatat agagaagcag aatttctacc ggaagcgtca cgtggaattt      900

tacttttgga tggttatagg cacgttcgaa ccggagtttt cgagcagcag aattgcattc      960

gcaaaaattg cgacactgat gactatccta gatgatctct atgatactca cggaacgttg     1020

gaacaactaa aaatcttcac agaagcagtc aaacgatggg atctttcatt acaagaccgt     1080

cttccagact acataaagat tactctggaa ttcttcttca acacatccaa tgaattgaat     1140

gccgaagttg ctaaaatgca agaacgggat atgtcagcct acatacgaaa agcaggctgg     1200

gaacgataca ttgaagggta tatgcaagag tccgaatgga tggcggctcg acatgtccct     1260

acgtttgacg attacatgaa gaatggcaaa cgcagctctg gaatgtgtat actaaatttg     1320

tattcgcttc tcttaatggg gcaacttgta ccggacaaca ttctggagca aatacacctt     1380

ccatccaaga tccatgagct tgtggaattg acggccagac tggtcgacga ctcaaaggat     1440

ttccaggcga agaaggatgg tggggagttt gcttcaggta cagagtgcta cttgaaagag     1500

aagcctgaat gtacagagga agatgcaatg aatcatctca ttgggctcct caatctgaca     1560

gcgatggaat taaattggga atttgtaaaa catgacggtg tggcgctgtg tctcaagaag     1620

ttcgtcttcg aagttgcacg aggtctccga ttcatctaca aatacagaga cggctttgac     1680

tattccaacg aggagatgaa aagccagata accaaaatcc ttatcgatca agtgcccatc     1740

tga                                                                   1743


<210>  5
<211>  1743
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized PsTPS3 gene

<400>  5
atggcccaaa tttctattgg tgctccattg tctgctgaag ttaatggtgc ttgtattaac       60

acccatcatc atggtaattt gtgggacgat tacttcatcc aatctttgaa gtctccatac      120

gaagctccag aatgtcacga aagatgtgaa aagatgatcg aagaagtcaa gcacttgttg      180

ttgtccgaaa tgagagatgg taacgacgat ttgatcaaga gattgcaaat ggtcgatatc      240

ttcgaatgct tgggtatcga tagacatttc catcacgaaa ttcaagctgc tttggattac      300

gtttacagat actggaatga attggaaggt atcggtgttg gtactagaga ttctttgact      360

aaggacttgt atgctactgg tttgggtttt agagctttga gattgcacag atacaacgtt      420

tcttcagccg ttttggaaaa cttcaagaac gaaaacggtt tgttcttcca ttcctctgct      480

gttcaagaag aagaagttag atgtatgttg accttgttga gagcctccga aatttcattt      540

ccaggtgaaa aggttatgga tgaagctaag gcttttgcta ccgaatactt gaatcaatta      600

ttgaccagag tcgacatcac cgaagttggt gaaaatttgt taagagaagt cagatacgcc      660

ttggattttc catggtactg ttctgttcca agatgggaag ctagatcctt cattgaaatt      720

ttcggtcaaa acaactcctg gttgaagtcc actatgaaca agaaggtttt ggaattggcc      780

aagttggatt tcaacatctt gcaatctgct caccaaagag aattacaatt attgtctaga      840

tggtggtccc aatccgatat cgaaaagcaa aatttctaca gaaagagaca cgtcgaattc      900

tacttttgga tggttatcgg tactttcgaa ccagaattct cctcatctag aattgctttc      960

gctaagattg ctaccttgat gaccattttg gatgacttgt acgatactca cggtacattg     1020

gaacaattga agattttcac cgaagccgtt aagagatggg atttgtcttt acaagataga     1080

ttgccagact acatcaagat caccttggaa tttttcttca acacctccaa cgaattgaac     1140

gctgaagttg ctaaaatgca agaaagagat atgtccgcct acattagaaa agctggttgg     1200

gaaagatata tcgaaggtta catgcaagaa tccgaatgga tggctgctag acatgttcca     1260

acttttgatg actacatgaa gaacggtaag agatcttctg gtatgtgcat cttgaacttg     1320

tattctttgt tgttgatggg tcaattggtc ccagacaaca ttttggaaca aatccatttg     1380

ccatccaaga tccacgaatt ggttgaattg actgctagat tggttgatga ctccaaggat     1440

ttccaagcta aaaaggatgg tggtgaattt gcttctggta ctgaatgcta cttgaaagaa     1500

aagccagaat gcactgaaga agatgccatg aatcatttga tcggtttgtt gaatttgacc     1560

gccatggaat tgaactggga attcgtaaaa catgatggtg ttgctttgtg cttgaagaag     1620

ttcgttttcg aagttgcaag aggtttaaga ttcatctaca agtacagaga tggtttcgac     1680

tactctaacg aagaaatgaa gtctcaaatc accaagattt tgatcgacca agtcccaatc     1740

taa                                                                   1743


<210>  6
<211>  557
<212>  PRT
<213>  Arabidopsis thaliana

<400>  6

Met Glu Ala Leu Gly Asn Phe Asp Tyr Glu Ser Tyr Thr Asn Phe Thr 
1               5                   10                  15      


Lys Leu Pro Ser Ser Gln Trp Gly Asp Gln Phe Leu Lys Phe Ser Ile 
            20                  25                  30          


Ala Asp Ser Asp Phe Asp Val Leu Glu Arg Glu Ile Glu Val Leu Lys 
        35                  40                  45              


Pro Lys Val Arg Glu Asn Ile Phe Val Ser Ser Ser Thr Asp Lys Asp 
    50                  55                  60                  


Ala Met Lys Lys Thr Ile Leu Ser Ile His Phe Leu Asp Ser Leu Gly 
65                  70                  75                  80  


Leu Ser Tyr His Phe Glu Lys Glu Ile Glu Glu Ser Leu Lys His Ala 
                85                  90                  95      


Phe Glu Lys Ile Glu Asp Leu Ile Ala Asp Glu Asn Lys Leu His Thr 
            100                 105                 110         


Ile Ser Thr Ile Phe Arg Val Phe Arg Thr Tyr Gly Tyr Tyr Met Ser 
        115                 120                 125             


Ser Asp Val Phe Lys Ile Phe Lys Gly Asp Asp Gly Lys Phe Lys Glu 
    130                 135                 140                 


Ser Leu Ile Glu Asp Val Lys Gly Met Leu Ser Phe Tyr Glu Ala Val 
145                 150                 155                 160 


His Phe Gly Thr Thr Thr Asp His Ile Leu Asp Glu Ala Leu Ser Phe 
                165                 170                 175     


Thr Leu Asn His Leu Glu Ser Leu Ala Thr Gly Arg Arg Ala Ser Pro 
            180                 185                 190         


Pro His Ile Ser Lys Leu Ile Gln Asn Ala Leu His Ile Pro Gln His 
        195                 200                 205             


Arg Asn Ile Gln Ala Leu Val Ala Arg Glu Tyr Ile Ser Phe Tyr Glu 
    210                 215                 220                 


His Glu Glu Asp His Asp Glu Thr Leu Leu Lys Leu Ala Lys Leu Asn 
225                 230                 235                 240 


Phe Lys Phe Leu Gln Leu His Tyr Phe Gln Glu Leu Lys Thr Ile Thr 
                245                 250                 255     


Met Trp Trp Thr Lys Leu Asp His Thr Ser Asn Leu Pro Pro Asn Phe 
            260                 265                 270         


Arg Glu Arg Thr Val Glu Thr Trp Phe Ala Ala Leu Met Met Tyr Phe 
        275                 280                 285             


Glu Pro Gln Phe Ser Leu Gly Arg Ile Met Ser Ala Lys Leu Tyr Leu 
    290                 295                 300                 


Val Ile Thr Phe Leu Asp Asp Ala Cys Asp Thr Tyr Gly Ser Ile Ser 
305                 310                 315                 320 


Glu Val Glu Ser Leu Ala Asp Cys Leu Glu Arg Trp Asp Pro Asp Tyr 
                325                 330                 335     


Met Glu Asn Leu Gln Gly His Met Lys Thr Ala Phe Lys Phe Val Met 
            340                 345                 350         


Tyr Leu Phe Lys Glu Tyr Glu Glu Ile Leu Arg Ser Gln Gly Arg Ser 
        355                 360                 365             


Phe Val Leu Glu Lys Met Ile Glu Glu Phe Lys Ile Ile Ala Arg Lys 
    370                 375                 380                 


Asn Leu Glu Leu Val Lys Trp Ala Arg Gly Gly His Val Pro Ser Phe 
385                 390                 395                 400 


Asp Glu Tyr Ile Glu Ser Gly Gly Ala Glu Ile Gly Thr Tyr Ala Thr 
                405                 410                 415     


Ile Ala Cys Ser Ile Met Gly Leu Gly Glu Ile Gly Lys Lys Glu Ala 
            420                 425                 430         


Phe Glu Trp Leu Ile Ser Arg Pro Lys Leu Val Arg Ile Leu Gly Ala 
        435                 440                 445             


Lys Thr Arg Leu Met Asp Asp Ile Ala Asp Phe Glu Glu Asp Met Glu 
    450                 455                 460                 


Lys Gly Tyr Thr Ala Asn Ala Leu Asn Tyr Tyr Met Asn Glu His Gly 
465                 470                 475                 480 


Val Thr Lys Glu Glu Ala Ser Arg Glu Leu Glu Lys Met Asn Gly Asp 
                485                 490                 495     


Met Asn Lys Ile Val Asn Glu Glu Cys Leu Lys Ile Thr Thr Met Pro 
            500                 505                 510         


Arg Arg Ile Leu Met Gln Ser Val Asn Tyr Ala Arg Ser Leu Asp Val 
        515                 520                 525             


Leu Tyr Thr Ala Asp Asp Val Tyr Asn His Arg Glu Gly Lys Leu Lys 
    530                 535                 540                 


Glu Tyr Met Arg Leu Leu Leu Val Asp Pro Ile Leu Leu 
545                 550                 555         


<210>  7
<211>  580
<212>  PRT
<213>  Pinus sylvestris

<400>  7

Met Ala Gln Ile Ser Ile Gly Ala Pro Leu Ser Ala Glu Val Asn Gly 
1               5                   10                  15      


Ala Cys Ile Asn Thr His His His Gly Asn Leu Trp Asp Asp Tyr Phe 
            20                  25                  30          


Ile Gln Ser Leu Lys Ser Pro Tyr Glu Ala Pro Glu Cys His Glu Arg 
        35                  40                  45              


Cys Glu Lys Met Ile Glu Glu Val Lys His Leu Leu Leu Ser Glu Met 
    50                  55                  60                  


Arg Asp Gly Asn Asp Asp Leu Ile Lys Arg Leu Gln Met Val Asp Ile 
65                  70                  75                  80  


Phe Glu Cys Leu Gly Ile Asp Arg His Phe His His Glu Ile Gln Ala 
                85                  90                  95      


Ala Leu Asp Tyr Val Tyr Arg Tyr Trp Asn Glu Leu Glu Gly Ile Gly 
            100                 105                 110         


Val Gly Thr Arg Asp Ser Leu Thr Lys Asp Leu Tyr Ala Thr Gly Leu 
        115                 120                 125             


Gly Phe Arg Ala Leu Arg Leu His Arg Tyr Asn Val Ser Ser Ala Val 
    130                 135                 140                 


Leu Glu Asn Phe Lys Asn Glu Asn Gly Leu Phe Phe His Ser Ser Ala 
145                 150                 155                 160 


Val Gln Glu Glu Glu Val Arg Cys Met Leu Thr Leu Leu Arg Ala Ser 
                165                 170                 175     


Glu Ile Ser Phe Pro Gly Glu Lys Val Met Asp Glu Ala Lys Ala Phe 
            180                 185                 190         


Ala Thr Glu Tyr Leu Asn Gln Leu Leu Thr Arg Val Asp Ile Thr Glu 
        195                 200                 205             


Val Gly Glu Asn Leu Leu Arg Glu Val Arg Tyr Ala Leu Asp Phe Pro 
    210                 215                 220                 


Trp Tyr Cys Ser Val Pro Arg Trp Glu Ala Arg Ser Phe Ile Glu Ile 
225                 230                 235                 240 


Phe Gly Gln Asn Asn Ser Trp Leu Lys Ser Thr Met Asn Lys Lys Val 
                245                 250                 255     


Leu Glu Leu Ala Lys Leu Asp Phe Asn Ile Leu Gln Ser Ala His Gln 
            260                 265                 270         


Arg Glu Leu Gln Leu Leu Ser Arg Trp Trp Ser Gln Ser Asp Ile Glu 
        275                 280                 285             


Lys Gln Asn Phe Tyr Arg Lys Arg His Val Glu Phe Tyr Phe Trp Met 
    290                 295                 300                 


Val Ile Gly Thr Phe Glu Pro Glu Phe Ser Ser Ser Arg Ile Ala Phe 
305                 310                 315                 320 


Ala Lys Ile Ala Thr Leu Met Thr Ile Leu Asp Asp Leu Tyr Asp Thr 
                325                 330                 335     


His Gly Thr Leu Glu Gln Leu Lys Ile Phe Thr Glu Ala Val Lys Arg 
            340                 345                 350         


Trp Asp Leu Ser Leu Gln Asp Arg Leu Pro Asp Tyr Ile Lys Ile Thr 
        355                 360                 365             


Leu Glu Phe Phe Phe Asn Thr Ser Asn Glu Leu Asn Ala Glu Val Ala 
    370                 375                 380                 


Lys Met Gln Glu Arg Asp Met Ser Ala Tyr Ile Arg Lys Ala Gly Trp 
385                 390                 395                 400 


Glu Arg Tyr Ile Glu Gly Tyr Met Gln Glu Ser Glu Trp Met Ala Ala 
                405                 410                 415     


Arg His Val Pro Thr Phe Asp Asp Tyr Met Lys Asn Gly Lys Arg Ser 
            420                 425                 430         


Ser Gly Met Cys Ile Leu Asn Leu Tyr Ser Leu Leu Leu Met Gly Gln 
        435                 440                 445             


Leu Val Pro Asp Asn Ile Leu Glu Gln Ile His Leu Pro Ser Lys Ile 
    450                 455                 460                 


His Glu Leu Val Glu Leu Thr Ala Arg Leu Val Asp Asp Ser Lys Asp 
465                 470                 475                 480 


Phe Gln Ala Lys Lys Asp Gly Gly Glu Phe Ala Ser Gly Thr Glu Cys 
                485                 490                 495     


Tyr Leu Lys Glu Lys Pro Glu Cys Thr Glu Glu Asp Ala Met Asn His 
            500                 505                 510         


Leu Ile Gly Leu Leu Asn Leu Thr Ala Met Glu Leu Asn Trp Glu Phe 
        515                 520                 525             


Val Lys His Asp Gly Val Ala Leu Cys Leu Lys Lys Phe Val Phe Glu 
    530                 535                 540                 


Val Ala Arg Gly Leu Arg Phe Ile Tyr Lys Tyr Arg Asp Gly Phe Asp 
545                 550                 555                 560 


Tyr Ser Asn Glu Glu Met Lys Ser Gln Ile Thr Lys Ile Leu Ile Asp 
                565                 570                 575     


Gln Val Pro Ile 
            580 


<210>  8
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EIZS protein

<400>  8

Met His Ala Phe Pro His Gly Thr Thr Ala Thr Pro Thr Ala Ile Ala 
1               5                   10                  15      


Val Pro Pro Ser Leu Arg Leu Pro Val Ile Glu Ala Ala Phe Pro Arg 
            20                  25                  30          


Gln Leu His Pro Tyr Trp Pro Lys Leu Gln Glu Thr Thr Arg Thr Trp 
        35                  40                  45              


Leu Leu Glu Lys Arg Leu Met Pro Ala Asp Lys Val Glu Glu Tyr Ala 
    50                  55                  60                  


Asp Gly Leu Cys Tyr Thr Asp Leu Met Ala Gly Tyr Tyr Leu Gly Ala 
65                  70                  75                  80  


Pro Asp Glu Val Leu Gln Ala Ile Ala Asp Tyr Ser Ala Trp Phe Phe 
                85                  90                  95      


Val Trp Asp Asp Arg His Asp Arg Asp Ile Val His Gly Arg Ala Gly 
            100                 105                 110         


Ala Trp Arg Arg Leu Arg Gly Leu Leu His Thr Ala Leu Asp Ser Pro 
        115                 120                 125             


Gly Asp His Leu His His Glu Asp Thr Leu Val Ala Gly Phe Ala Asp 
    130                 135                 140                 


Ser Val Arg Arg Leu Tyr Ala Phe Leu Pro Ala Thr Trp Asn Ala Arg 
145                 150                 155                 160 


Phe Ala Arg His Phe His Thr Val Ile Glu Ala Tyr Asp Arg Glu Phe 
                165                 170                 175     


His Asn Arg Thr Arg Gly Ile Val Pro Gly Val Glu Glu Tyr Leu Glu 
            180                 185                 190         


Leu Arg Arg Leu Thr Phe Ala His Trp Ile Trp Thr Asp Leu Leu Glu 
        195                 200                 205             


Pro Ser Ser Gly Cys Glu Leu Pro Asp Ala Val Arg Lys His Pro Ala 
    210                 215                 220                 


Tyr Arg Arg Ala Ala Leu Leu Ser Gln Glu Phe Ala Ala Trp Tyr Asn 
225                 230                 235                 240 


Asp Leu Cys Ser Leu Pro Lys Glu Ile Ala Gly Asp Glu Val His Asn 
                245                 250                 255     


Leu Gly Ile Ser Leu Ile Thr His His Ser Leu Thr Leu Glu Glu Ala 
            260                 265                 270         


Ile Gly Glu Val Arg Arg Arg Val Glu Glu Cys Ile Thr Glu Phe Leu 
        275                 280                 285             


Ala Val Glu Arg Asp Ala Leu Arg Phe Ala Asp Glu Leu Ala Asp Gly 
    290                 295                 300                 


Thr Val Arg Gly Lys Glu Leu Ser Gly Ala Val Arg Ala Asn Val Gly 
305                 310                 315                 320 


Asn Met Arg Asn Trp Phe Ser Ser Val Tyr Trp Phe His His Glu Ser 
                325                 330                 335     


Gly Arg Tyr Met Val Asp Ser Trp Asp Asp Arg Ser Thr Pro Pro Tyr 
            340                 345                 350         


Val Asn Asn Glu Ala Ala Gly Glu Lys 
        355                 360     


