                         SEQUENCE LISTING

<110>  Immunotec Inc.
 
<120>  COMPOSITIONS FOR RESTORING GENE EXPRESSION IN NEUROPSYCHIATRIC OR
        NEURODEGENERATIVE DISORDERS

<130>  L80010126WO

<150>  US 62/398,892
<151>  2016-09-23

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  11580
<212>  DNA
<213>  homo sapien

<400>  1
cacgcgtggg ctcggcgggg gcccgctccc aggcccgctc ccgagcccgt tccgctcccg       60

tccgccttct tctcgccttc tctccgcgtg gctcctccgt cccggcgtct ccaaaactga      120

atgagcgagc ggcgcgtagg gcgscggcgg cggcggcggc ggcggcggcg gcggcatgga      180

gcgcagtggc tgggcccggc agactttcct cctagcgctg ttgctggggg cgacgctgag      240

ggcgcgcgcg gcggctggct attacccccg cttttcgccc ttctttttcc tgtgcaccca      300

ccacggggag ctggaagggg atggggagca gggcgaggtg ctcatttccc tgcatattgc      360

gggcaacccc acctactacg ttccgggaca agaataccat gtgacaattt caacaagcac      420

cttttttgac ggcttgctgg tgacaggact atacacatct acaagtgttc aggcatcaca      480

gagcattgga ggttccagtg ctttcggatt tgggatcatg tctgaccacc agtttggtaa      540

ccagtttatg tgcagtgtgg tagcctctca cgtgagtcac ctgcccacaa ccaacctcag      600

tttcatctgg attgctccac ctgcgggcac aggctgtgtg aatttcatgg ctacagcaac      660

acaccggggc caggttattt tcaaagatgc tttagcccag cagttgtgtg aacaaggagc      720

tccaacagat gtcactgtgc acccacatct agctgaaata catagtgaca gcattatcct      780

gagagatgac tttgactcct accaccaact gcaattaaat ccaaatatat gggttgaatg      840

taacaactgt gagactggag aacagtgtgg cgcgattatg catggcaatg ccgtcacctt      900

ctgtgaacca tatggcccac gagaactgat taccacaggc cttaatacaa caacagcttc      960

tgtcctccaa ttttccattg ggtcaggttc atgtcgcttt agttattcag accccagcat     1020

catcgtgtta tatgccaaga ataactctgc ggactggatt cagctagaga aaattagagc     1080

cccttccaat gtcagcacaa tcatccatat cctctacctt cctgaggacg ccaaagggga     1140

gaatgtccaa tttcagtgga agcaggaaaa tcttcgtgta ggtgaagtgt atgaagcctg     1200

ctgggcctta gataacatct tgatcatcaa ttcagctcac agacaagtcg ttttagaaga     1260

tagtctcgac ccagtggaca caggcaactg gcttttcttc ccaggagcta cagttaagca     1320

tagctgtcag tcagatggga actccattta tttccatgga aatgaaggca gcgagttcaa     1380

ttttgccacc accagggatg tagatctttc cacagaagat attcaagagc aatggtcaga     1440

agaatttgag agccagccta caggatggga tgtcttggga gctgtcattg gtacagaatg     1500

tggaacgata gaatcaggct tatcaatggt cttcctcaaa gatggagaga ggaaattatg     1560

cactccatcc atggacacta ccggttatgg gaacctgagg ttttactttg tgatgggagg     1620

aatttgtgac cctggaaatt ctcatgaaaa tgacataatc ctgtatgcaa aaattgaagg     1680

aagaaaagag catataacac tggataccct ttcctattcc tcatataagg ttccgtcttt     1740

ggtttctgtg gtcatcaatc ctgaacttca gactcctgct accaaatttt gtctcaggca     1800

aaagaaccat caaggacata ataggaatgt ctgggctgta gactttttcc atgtcttgcc     1860

tgttctccct tctacaatgt ctcacatgat acagttttcc atcaatctgg gatgtggaac     1920

gcatcagcct ggtaacagtg tcagcttgga attttctacc aaccatgggc gctcctggtc     1980

cctccttcac actgaatgct tacctgagat ctgtgctgga ccccacctcc cccacagcac     2040

tgtctactcc tctgaaaact acagtgggtg gaaccgaata acaattcccc ttcctaacgc     2100

agcactaacc cggaacacca ggattcgctg gagacaaaca ggaccaatcc ttggaaacat     2160

gtgggcaatt gataatgttt atattggccc gtcatgtctc aaattctgtt ctggcagagg     2220

acagtgcact agacatggtt gcaagtgtga ccctggattt tctggcccag cttgtgagat     2280

ggcatcccag acattcccaa tgtttatttc tgaaagcttt ggcagttcca ggctctcctc     2340

ttaccataac ttttactcta tccgtggtgc tgaagtcagc tttggttgtg gtgtcttggc     2400

cagtggtaag gccctggttt tcaacaaaga agggcggcgt cagctaatta catctttcct     2460

tgacagctca caatccaggt ttctccagtt cacactgaga ctggggagca aatctgttct     2520

gagcacgtgc agagcccctg atcagcctgg tgaaggagtt ttgctgcatt attcttatga     2580

taatgggata acttggaaac tcctggagca ttattcatat ctcagctatc atgagcccag     2640

aataatctcc gtagaactac caggtgatgc aaagcagttt ggaattcagt tcagatggtg     2700

gcaaccgtat cattcttccc agagagaaga tgtatgggct attgatgaga ttatcatgac     2760

atctgtgctt ttcaacagca ttagtcttga ctttaccaat cttgtggagg tcactcagtc     2820

tctgggattc taccttggaa atgttcagcc atactgtggc cacgactgga ccctttgttt     2880

tacaggagat tctaaacttg cctcaagtat gcgctatgtg gaaacacaat caatgcagat     2940

aggagcatcc tatatgattc agttcagttt ggtgatggga tgtggccaga aatacacccc     3000

acacatggac aaccaggtga agctggagta ctcaaccaac cacggcctta cctggcacct     3060

cgtccaagaa gaatgccttc caagtatgcc aagttgtcag gaatttacat cagcaagtat     3120

ttaccatgcc agtgagttta cacagtggag gagagtcata gtgcttcttc cccagaaaac     3180

ttggtccagt gctacccgtt tccgctggag ccagagctat tacacagctc aagacgagtg     3240

ggctttggac agcatttaca ttgggcagca gtgccccaac atgtgcagtg ggcatggctc     3300

atgcgatcat ggcatatgca ggtgtgacca ggggtaccaa ggcactgaat gccacccaga     3360

agctgccctt ccgtccacaa ttatgtcaga ttttgagaac cagaatggct gggagtctga     3420

ctggcaagaa gttattgggg gagaaattgt aaaaccagaa caagggtgtg gtgtcatctc     3480

ttctggatca tctctgtact tcagcaaggc tgggaaaaga cagctggtga gttgggacct     3540

ggatacttct tgggtggact ttgtccagtt ctacatccag ataggcggag agagtgcttc     3600

atgcaacaag cctgacagca gagaggaggg cgtcctcctt cagtacagca acaatggggg     3660

catccagtgg cacctgctag cagagatgta cttttcagac ttcagcaaac ccagatttgt     3720

ctatctggag cttccagctg ctgccaagac cccttgcacc aggttccgct ggtggcagcc     3780

cgtgttctca ggggaggact atgaccagtg ggcagtcgat gacatcatca ttctgtccga     3840

gaagcagaag cagatcatcc cagttatcaa tccaacttta cctcagaact tttatgagaa     3900

gccagctttt gattacccta tgaatcagat gagtgtgtgg ttgatgttgg ctaatgaagg     3960

aatggttaaa aatgaaacct tctgtgctgc cacaccatca gcaatgatat ttggaaaatc     4020

agatggagat cgatttgcag taactcgaga tttgaccctg aaacctggat atgtgctaca     4080

gttcaagcta aacataggtt gtgccaatca attcagcagt actgctccag ttcttcttca     4140

gtactctcat gatgctggta tgtcctggtt tctggtgaaa gaaggctgtt acccggcttc     4200

tgcaggcaaa ggatgcgaag gaaactccag agaactaagt gagcccacca tgtatcacac     4260

aggggacttt gaagaatgga caagaatcac cattgttatt ccaaggtctc ttgcatccag     4320

caagaccaga ttccgatgga tccaggagag cagctcacag aaaaacgtgc ctccatttgg     4380

tttagatgga gtgtacatat ccgagccttg tcccagttac tgcagtggcc atggggactg     4440

catttcagga gtgtgtttct gtgacctggg atatactgct gcacaaggaa cctgtgtgtc     4500

aaatgtcccc aatcacaatg agatgttcga taggtttgag gggaagctca gccctctgtg     4560

gtacaagata acaggtgccc aggttggaac tggctgtgga acacttaacg atggcaaatc     4620

tctctacttc aatggccctg ggaaaaggga agcccggacg gtccctctgg acaccaggaa     4680

tatcagactt gttcaatttt atatacaaat tggaagcaaa acttcaggca ttacctgcat     4740

caaaccaaga actagaaatg aagggcttat tgttcagtat tcaaatgaca atgggatact     4800

ctggcatttg cttcgagagt tggacttcat gtccttcctg gaaccacaga tcatttccat     4860

tgacctgcca caggacgcga agacacctgc aacggcattt cgatggtggc aaccgcaaca     4920

tgggaagcat tcagcccagt gggctttgga tgatgttctt ataggaatga atgacagctc     4980

tcaaactgga tttcaagaca aatttgatgg ctctatagat ttgcaagcca actggtatcg     5040

aatccaagga ggtcaagttg atattgactg tctctctatg gatactgctc tgatattcac     5100

tgaaaacata ggaaaacctc gttatgctga gacctgggat tttcatgtgt cagcatctac     5160

ctttttgcag tttgaaatga gcatgggctg tagcaagccc ttcagcaact cccacagtgt     5220

acagctccag tattctctga acaatggcaa ggactggcat cttgtcaccg aagagtgtgt     5280

tcctccaacc attggctgtc tgcattacac ggaaagttca atttacacct cggaaagatt     5340

ccagaattgg aagcggatca ctgtctacct tccactctcc accatttctc ccaggacccg     5400

gttcagatgg attcaggcca actacactgt gggggctgat tcctgggcga ttgataatgt     5460

tgtactggcc tcagggtgcc cttggatgtg ctcaggacga gggatttgtg atgctggacg     5520

ctgtgtgtgt gaccggggct ttggtggacc ctattgtgtt cctgttgttc ctctgccctc     5580

gattcttaaa gacgatttca atgggaattt acatcctgac ctttggcctg aagtgtatgg     5640

tgcagagagg gggaatctga atggtgaaac catcaaatct ggaacatctc taatttttaa     5700

aggggaagga ctaaggatgc ttatttcaag agatctagat tgtacaaata caatgtatgt     5760

ccagttttca cttagattta tagcaaaaag taccccagag agatctcact ctattctgtt     5820

acaattctcc atcagtggag gaatcacttg gcacctgatg gatgaatttt actttcctca     5880

aacaacgaat atacttttca tcaatgttcc cttgccatac actgcccaaa ccaatgctac     5940

aagattcaga ctctggcaac cttataataa cggtaagaaa gaagaaatct ggattgttga     6000

tgacttcatt atcgatggaa ataatgtaaa caaccctgtg atgctcttgg atacatttga     6060

ttttgggccc agagaagaca attggttttt ctatcctggt ggtaacatcg gtctttattg     6120

tccatattct tcaaaggggg cacctgaaga agattcagct atggtgtttg tttcaaatga     6180

agttggtgag cattccatta ccacccgtga cctaaatgtg aatgagaaca ccatcataca     6240

atttgagatc aacgttggct gttcgactga tagctcatcc gcggatccag tgagactgga     6300

attttcaagg gacttcgggg cgacctggca ccttctgctg cccctctgct accacagcag     6360

cagccacgtc agctctttat gctccaccga gcaccacccc agcagcacct actacgcagg     6420

aaccatgcag ggctggagga gggaggtcgt gcactttggg aagctgcacc tttgtggatc     6480

tgtccgtttc agatggtacc agggatttta ccctgccggc tctcagccag tgacatgggc     6540

cattgataat gtctacatcg gtccccagtg tgaggagatg tgtaatggac aggggagctg     6600

tatcaatgga accaaatgta tatgtgaccc tggctactca ggtccaacct gtaaaataag     6660

caccaaaaat cctgattttc tcaaagatga tttcgaaggt cagctagaat ctgatagatt     6720

cttattaatg agtggtggga aaccatctcg aaagtgtgga atcctttcta gtggaaacaa     6780

cctctttttc aatgaagatg gcttgcgcat gttgatgaca cgagacctgg atttatcaca     6840

tgctagattt gtgcagttct tcatgagact gggatgtggt aaaggcgttc ctgaccccag     6900

gagtcaaccc gtgctcctac agtattctct caacggtggc ctctcgtgga gtcttcttca     6960

ggagttcctt ttcagcaatt ccagcaatgt gggcaggtac attgccctgg agataccctt     7020

gaaagcccgt tctggttcta ctcgccttcg ctggtggcaa ccgtctgaga atgggcactt     7080

ctacagcccc tgggttatcg atcagattct tattggagga aatatttctg gtaatacggt     7140

cttggaagat gatttcacaa cccttgatag taggaaatgg ctgcttcacc caggaggcac     7200

caagatgccc gtgtgtggct ctactggtga tgccctggtc ttcattgaaa aggccagcac     7260

ccgttacgtg gtcagcacag acgttgccgt gaatgaggat tccttcctac agatagactt     7320

cgctgcctcc tgctcagtca cagactcttg ttatgcgatt gaattggaat actcagtaga     7380

tcttggattg tcatggcacc cattggtaag ggactgtctg cctaccaatg tggaatgcag     7440

tcgctatcat ctgcaacgga tcctggtgtc agacactttc aacaagtgga ctagaatcac     7500

tctgcctctc cctccttata ccaggtccca agccactcgt ttccgttggc atcaaccagc     7560

tccttttgac aagcagcaga catgggcaat agataatgtc tatatcgggg atggctgcat     7620

agacatgtgc agtggccatg ggagatgcat ccagggaaac tgcgtctgtg atgaacagtg     7680

gggtggcctg tactgtgatg accccgagac ctctcttcca acccaactca aagacaactt     7740

caatcgagct ccatccagtc agaactggct gactgtgaac ggagggaaat tgagtacagt     7800

gtgtggagcc gtggcgtcgg gaatggctct ccatttcagt gggggttgta gtcgattatt     7860

agtcactgtg gatctaaacc tcactaatgc tgagttcatc caattttact tcatgtatgg     7920

gtgcctgatt acaccaaaca accgtaacca aggtgttctc ttggaatatt ctgtcaatgg     7980

aggcattacc tggaacctgc tcatggagat tttctatgac cagtacagta agcccggatt     8040

tgtgaatatc cttctccctc ctgatgctaa agagattgcc actcgcttcc gctggtggca     8100

gccaagacat gacggcctgg atcagaacga ctgggccatt gacaatgtcc tcatctcagg     8160

ctctgctgac caaaggaccg ttatgctgga caccttcagc agcgccccag taccccagca     8220

cgagcgctcc cctgcagatg ccggccctgt cgggaggatc gcctttgaca tgtttatgga     8280

agacaaaact tcagtgaatg agcactggct attccatgat gattgtacag tagaaagatt     8340

ctgtgactcc cctgatggtg tgatgctctg tggcagtcat gatggacggg aggtgtatgc     8400

agtgacccat gacctgactc ccactgaagg ctggattatg caattcaaga tctcagttgg     8460

atgtaaggtg tctgaaaaaa ttgcccagaa tcaaattcat gtgcagtatt ctactgactt     8520

cggtgtgagt tggaattatc tggtccctca gtgcttgcct gctgacccaa aatgctctgg     8580

aagtgtttct cagccatctg tattctttcc aactaaaggg tggaaaagga tcacctaccc     8640

acttcctgaa agcttagtgg gaaatccggt aaggtttagg ttctatcaga agtactcaga     8700

catgcagtgg gcaatcgata atttctacct gggccctgga tgcttggaca actgcagggg     8760

ccatggagat tgcttaaggg aacagtgcat ctgtgatccg ggatactcag ggccaaactg     8820

ctacttgacc cacactctga agactttcct gaaggaacgc tttgacagtg aagaaatcaa     8880

acctgactta tggatgtcct tagaaggtgg aagtacttgc actgagtgtg gaattcttgc     8940

cgaggacact gcactctatt ttgggggatc cactgtgaga caagcggtta cacaagattt     9000

ggatcttcga ggtgcaaagt tcctgcaata ctgggggcgc atcggtagtg agaacaacat     9060

gacctcttgc catcgtccca tctgccggaa ggaaggcgtg ctgttggact actctaccga     9120

tggaggaatt acctggactt tgctccatga gatggattac cagaaataca tttctgttag     9180

acacgactac atacttcttc ctgaagatgc cctcaccaac acaactcgac ttcgctggtg     9240

gcagcctttt gtgatcagca atggaattgt ggtctctggg gtggagcgtg ctcagtgggc     9300

actggacaac attttgattg gtggagcaga aatcaatccc agccaattgg tggacacttt     9360

tgatgatgaa ggcacttccc atgaagaaaa ctggagtttt taccctaatg ctgtaaggac     9420

agcaggattt tgtggcaatc catcctttca cctctattgg ccaaataaaa agaaggacaa     9480

gactcacaat gctctctcct cccgagaact cattatacag ccaggataca tgatgcagtt     9540

taaaattgtg gtgggttgtg aagccacttc ttgtggtgac cttcattccg taatgctgga     9600

atacactaag gatgcaagat cggattcctg gcagctcgta cagacccagt gccttccttc     9660

ctcttctaac agcattggct gctccccttt ccagttccat gaagccacca tctacaactc     9720

tgtcaacagc tcaagctgga aaagaatcac catccagctg cctgaccatg tctcctctag     9780

tgcaacacag ttccgctgga tccagaaggg agaagaaact gagaagcaaa gctgggcaat     9840

tgaccacgtg tacattggag aggcttgccc caagctctgc agcgggcacg gatactgcac     9900

gaccggtgcc atctgcatct gcgacgagag cttccaaggt gatgactgct ctgttttcag     9960

tcacgacctt cccagttata ttaaagataa ttttgagtcc gcaagagtca ccgaggcaaa    10020

ctgggagacc attcaaggtg gagtcatagg aagtggctgt gggcagctgg ccccctacgc    10080

ccatggagac tcactgtact ttaatggctg tcagatcagg caagcagcta ccaagcctct    10140

ggatctcact cgagcaagca aaatcatgtt tgttttgcaa attgggagca tgtcgcagac    10200

ggacagctgc aacagtgacc tgagtggccc ccacgctgtg gacaaggcgg tgctgctgca    10260

atacagcgtc aacaacggga tcacctggca tgtcatcgcc cagcaccagc caaaggactt    10320

cacacaagct cagagagtgt cttacaatgt ccccctggag gcacggatga aaggagtctt    10380

actgcgctgg tggcaaccac gccacaatgg aacaggtcat gatcaatggg ctttggacca    10440

tgtggaggtc gtcctagtaa gcactcgcaa acaaaattac atgatgaatt tttcacgaca    10500

acatgggctc agacatttct acaacagaag acgaaggtca cttaggcgat acccatgaag    10560

aatcaaaaag tttatttttt ttcttccaac atgtgatgtg ttgctctcca ttcttttaaa    10620

tctcgcacta catctgatat caggaaatat ctgtgaagga cttggtgatt acctgaaagc    10680

ccttctcaag accgagtgta caccactttc ccacactgtg aactaatgac aagtgactta    10740

tttgctcata agtaaatgtc ttcatgttga tgtgtccgtg aaagttgtga tctgttgtaa    10800

tatcagttac agtggcagta ttgacaataa gaaacagttt aacagaaaaa tgaaatttaa    10860

gcacaaaaaa tttaagagat tttatgttta aaatggcatt tagcacagta tttaacattc    10920

ttggtcacaa agctatttaa gtggactgta tttcagctat gtctcatgtt ttatatgatt    10980

aaattatcat tgtttgtcct ttatgtattc tcttctacaa tacaacacat tgaaactgta    11040

tttacttgtt atgttgtaat attttgctgc tgaatttggg gctacttata ttctgcagaa    11100

aattaattga aatacctatt caagaagata gttgtaaaga tattgtatct cctttaatat    11160

actccttaaa aatgtatgtt ggtttagcgt tgttttgtgg ataagaaaaa tgcttgaccc    11220

tgaaatattt tctactttaa attgtggatg aagaccctat ctcccacaaa taagttccca    11280

tttccttgtc taaagatctt tttttaagtg ttctgtggct gatttactaa cagtaactgc    11340

cattttttgt ctgtgataac agagtgattt gtaaaacagt ggttgttttt tcattgtgtt    11400

ttcttcgtgg attgtttttt ctgcgggtca tattcatacc ttctgatgaa gttgtacaac    11460

accagcaaca ttataatggc cctgtagctc tgaatgctat ttgtgtaact gaaaggttgc    11520

actctagggt gaaccaagct ataaaagccc atgcttaaat aaaaattatg tccaaaagcc    11580


<210>  2
<211>  3460
<212>  PRT
<213>  homo sapien

<400>  2

Met Glu Arg Ser Gly Trp Ala Arg Gln Thr Phe Leu Leu Ala Leu Leu 
1               5                   10                  15      


Leu Gly Ala Thr Leu Arg Ala Arg Ala Ala Ala Gly Tyr Tyr Pro Arg 
            20                  25                  30          


Phe Ser Pro Phe Phe Phe Leu Cys Thr His His Gly Glu Leu Glu Gly 
        35                  40                  45              


Asp Gly Glu Gln Gly Glu Val Leu Ile Ser Leu His Ile Ala Gly Asn 
    50                  55                  60                  


Pro Thr Tyr Tyr Val Pro Gly Gln Glu Tyr His Val Thr Ile Ser Thr 
65                  70                  75                  80  


Ser Thr Phe Phe Asp Gly Leu Leu Val Thr Gly Leu Tyr Thr Ser Thr 
                85                  90                  95      


Ser Val Gln Ala Ser Gln Ser Ile Gly Gly Ser Ser Ala Phe Gly Phe 
            100                 105                 110         


Gly Ile Met Ser Asp His Gln Phe Gly Asn Gln Phe Met Cys Ser Val 
        115                 120                 125             


Val Ala Ser His Val Ser His Leu Pro Thr Thr Asn Leu Ser Phe Ile 
    130                 135                 140                 


Trp Ile Ala Pro Pro Ala Gly Thr Gly Cys Val Asn Phe Met Ala Thr 
145                 150                 155                 160 


Ala Thr His Arg Gly Gln Val Ile Phe Lys Asp Ala Leu Ala Gln Gln 
                165                 170                 175     


Leu Cys Glu Gln Gly Ala Pro Thr Asp Val Thr Val His Pro His Leu 
            180                 185                 190         


Ala Glu Ile His Ser Asp Ser Ile Ile Leu Arg Asp Asp Phe Asp Ser 
        195                 200                 205             


Tyr His Gln Leu Gln Leu Asn Pro Asn Ile Trp Val Glu Cys Asn Asn 
    210                 215                 220                 


Cys Glu Thr Gly Glu Gln Cys Gly Ala Ile Met His Gly Asn Ala Val 
225                 230                 235                 240 


Thr Phe Cys Glu Pro Tyr Gly Pro Arg Glu Leu Ile Thr Thr Gly Leu 
                245                 250                 255     


Asn Thr Thr Thr Ala Ser Val Leu Gln Phe Ser Ile Gly Ser Gly Ser 
            260                 265                 270         


Cys Arg Phe Ser Tyr Ser Asp Pro Ser Ile Ile Val Leu Tyr Ala Lys 
        275                 280                 285             


Asn Asn Ser Ala Asp Trp Ile Gln Leu Glu Lys Ile Arg Ala Pro Ser 
    290                 295                 300                 


Asn Val Ser Thr Ile Ile His Ile Leu Tyr Leu Pro Glu Asp Ala Lys 
305                 310                 315                 320 


Gly Glu Asn Val Gln Phe Gln Trp Lys Gln Glu Asn Leu Arg Val Gly 
                325                 330                 335     


Glu Val Tyr Glu Ala Cys Trp Ala Leu Asp Asn Ile Leu Ile Ile Asn 
            340                 345                 350         


Ser Ala His Arg Gln Val Val Leu Glu Asp Ser Leu Asp Pro Val Asp 
        355                 360                 365             


Thr Gly Asn Trp Leu Phe Phe Pro Gly Ala Thr Val Lys His Ser Cys 
    370                 375                 380                 


Gln Ser Asp Gly Asn Ser Ile Tyr Phe His Gly Asn Glu Gly Ser Glu 
385                 390                 395                 400 


Phe Asn Phe Ala Thr Thr Arg Asp Val Asp Leu Ser Thr Glu Asp Ile 
                405                 410                 415     


Gln Glu Gln Trp Ser Glu Glu Phe Glu Ser Gln Pro Thr Gly Trp Asp 
            420                 425                 430         


Val Leu Gly Ala Val Ile Gly Thr Glu Cys Gly Thr Ile Glu Ser Gly 
        435                 440                 445             


Leu Ser Met Val Phe Leu Lys Asp Gly Glu Arg Lys Leu Cys Thr Pro 
    450                 455                 460                 


Ser Met Asp Thr Thr Gly Tyr Gly Asn Leu Arg Phe Tyr Phe Val Met 
465                 470                 475                 480 


Gly Gly Ile Cys Asp Pro Gly Asn Ser His Glu Asn Asp Ile Ile Leu 
                485                 490                 495     


Tyr Ala Lys Ile Glu Gly Arg Lys Glu His Ile Thr Leu Asp Thr Leu 
            500                 505                 510         


Ser Tyr Ser Ser Tyr Lys Val Pro Ser Leu Val Ser Val Val Ile Asn 
        515                 520                 525             


Pro Glu Leu Gln Thr Pro Ala Thr Lys Phe Cys Leu Arg Gln Lys Asn 
    530                 535                 540                 


His Gln Gly His Asn Arg Asn Val Trp Ala Val Asp Phe Phe His Val 
545                 550                 555                 560 


Leu Pro Val Leu Pro Ser Thr Met Ser His Met Ile Gln Phe Ser Ile 
                565                 570                 575     


Asn Leu Gly Cys Gly Thr His Gln Pro Gly Asn Ser Val Ser Leu Glu 
            580                 585                 590         


Phe Ser Thr Asn His Gly Arg Ser Trp Ser Leu Leu His Thr Glu Cys 
        595                 600                 605             


Leu Pro Glu Ile Cys Ala Gly Pro His Leu Pro His Ser Thr Val Tyr 
    610                 615                 620                 


Ser Ser Glu Asn Tyr Ser Gly Trp Asn Arg Ile Thr Ile Pro Leu Pro 
625                 630                 635                 640 


Asn Ala Ala Leu Thr Arg Asn Thr Arg Ile Arg Trp Arg Gln Thr Gly 
                645                 650                 655     


Pro Ile Leu Gly Asn Met Trp Ala Ile Asp Asn Val Tyr Ile Gly Pro 
            660                 665                 670         


Ser Cys Leu Lys Phe Cys Ser Gly Arg Gly Gln Cys Thr Arg His Gly 
        675                 680                 685             


Cys Lys Cys Asp Pro Gly Phe Ser Gly Pro Ala Cys Glu Met Ala Ser 
    690                 695                 700                 


Gln Thr Phe Pro Met Phe Ile Ser Glu Ser Phe Gly Ser Ser Arg Leu 
705                 710                 715                 720 


Ser Ser Tyr His Asn Phe Tyr Ser Ile Arg Gly Ala Glu Val Ser Phe 
                725                 730                 735     


Gly Cys Gly Val Leu Ala Ser Gly Lys Ala Leu Val Phe Asn Lys Glu 
            740                 745                 750         


Gly Arg Arg Gln Leu Ile Thr Ser Phe Leu Asp Ser Ser Gln Ser Arg 
        755                 760                 765             


Phe Leu Gln Phe Thr Leu Arg Leu Gly Ser Lys Ser Val Leu Ser Thr 
    770                 775                 780                 


Cys Arg Ala Pro Asp Gln Pro Gly Glu Gly Val Leu Leu His Tyr Ser 
785                 790                 795                 800 


Tyr Asp Asn Gly Ile Thr Trp Lys Leu Leu Glu His Tyr Ser Tyr Leu 
                805                 810                 815     


Ser Tyr His Glu Pro Arg Ile Ile Ser Val Glu Leu Pro Gly Asp Ala 
            820                 825                 830         


Lys Gln Phe Gly Ile Gln Phe Arg Trp Trp Gln Pro Tyr His Ser Ser 
        835                 840                 845             


Gln Arg Glu Asp Val Trp Ala Ile Asp Glu Ile Ile Met Thr Ser Val 
    850                 855                 860                 


Leu Phe Asn Ser Ile Ser Leu Asp Phe Thr Asn Leu Val Glu Val Thr 
865                 870                 875                 880 


Gln Ser Leu Gly Phe Tyr Leu Gly Asn Val Gln Pro Tyr Cys Gly His 
                885                 890                 895     


Asp Trp Thr Leu Cys Phe Thr Gly Asp Ser Lys Leu Ala Ser Ser Met 
            900                 905                 910         


Arg Tyr Val Glu Thr Gln Ser Met Gln Ile Gly Ala Ser Tyr Met Ile 
        915                 920                 925             


Gln Phe Ser Leu Val Met Gly Cys Gly Gln Lys Tyr Thr Pro His Met 
    930                 935                 940                 


Asp Asn Gln Val Lys Leu Glu Tyr Ser Thr Asn His Gly Leu Thr Trp 
945                 950                 955                 960 


His Leu Val Gln Glu Glu Cys Leu Pro Ser Met Pro Ser Cys Gln Glu 
                965                 970                 975     


Phe Thr Ser Ala Ser Ile Tyr His Ala Ser Glu Phe Thr Gln Trp Arg 
            980                 985                 990         


Arg Val Ile Val Leu Leu Pro Gln  Lys Thr Trp Ser Ser  Ala Thr Arg 
        995                 1000                 1005             


Phe Arg  Trp Ser Gln Ser Tyr  Tyr Thr Ala Gln Asp  Glu Trp Ala 
    1010                 1015                 1020             


Leu Asp  Ser Ile Tyr Ile Gly  Gln Gln Cys Pro Asn  Met Cys Ser 
    1025                 1030                 1035             


Gly His  Gly Ser Cys Asp His  Gly Ile Cys Arg Cys  Asp Gln Gly 
    1040                 1045                 1050             


Tyr Gln  Gly Thr Glu Cys His  Pro Glu Ala Ala Leu  Pro Ser Thr 
    1055                 1060                 1065             


Ile Met  Ser Asp Phe Glu Asn  Gln Asn Gly Trp Glu  Ser Asp Trp 
    1070                 1075                 1080             


Gln Glu  Val Ile Gly Gly Glu  Ile Val Lys Pro Glu  Gln Gly Cys 
    1085                 1090                 1095             


Gly Val  Ile Ser Ser Gly Ser  Ser Leu Tyr Phe Ser  Lys Ala Gly 
    1100                 1105                 1110             


Lys Arg  Gln Leu Val Ser Trp  Asp Leu Asp Thr Ser  Trp Val Asp 
    1115                 1120                 1125             


Phe Val  Gln Phe Tyr Ile Gln  Ile Gly Gly Glu Ser  Ala Ser Cys 
    1130                 1135                 1140             


Asn Lys  Pro Asp Ser Arg Glu  Glu Gly Val Leu Leu  Gln Tyr Ser 
    1145                 1150                 1155             


Asn Asn  Gly Gly Ile Gln Trp  His Leu Leu Ala Glu  Met Tyr Phe 
    1160                 1165                 1170             


Ser Asp  Phe Ser Lys Pro Arg  Phe Val Tyr Leu Glu  Leu Pro Ala 
    1175                 1180                 1185             


Ala Ala  Lys Thr Pro Cys Thr  Arg Phe Arg Trp Trp  Gln Pro Val 
    1190                 1195                 1200             


Phe Ser  Gly Glu Asp Tyr Asp  Gln Trp Ala Val Asp  Asp Ile Ile 
    1205                 1210                 1215             


Ile Leu  Ser Glu Lys Gln Lys  Gln Ile Ile Pro Val  Ile Asn Pro 
    1220                 1225                 1230             


Thr Leu  Pro Gln Asn Phe Tyr  Glu Lys Pro Ala Phe  Asp Tyr Pro 
    1235                 1240                 1245             


Met Asn  Gln Met Ser Val Trp  Leu Met Leu Ala Asn  Glu Gly Met 
    1250                 1255                 1260             


Val Lys  Asn Glu Thr Phe Cys  Ala Ala Thr Pro Ser  Ala Met Ile 
    1265                 1270                 1275             


Phe Gly  Lys Ser Asp Gly Asp  Arg Phe Ala Val Thr  Arg Asp Leu 
    1280                 1285                 1290             


Thr Leu  Lys Pro Gly Tyr Val  Leu Gln Phe Lys Leu  Asn Ile Gly 
    1295                 1300                 1305             


Cys Ala  Asn Gln Phe Ser Ser  Thr Ala Pro Val Leu  Leu Gln Tyr 
    1310                 1315                 1320             


Ser His  Asp Ala Gly Met Ser  Trp Phe Leu Val Lys  Glu Gly Cys 
    1325                 1330                 1335             


Tyr Pro  Ala Ser Ala Gly Lys  Gly Cys Glu Gly Asn  Ser Arg Glu 
    1340                 1345                 1350             


Leu Ser  Glu Pro Thr Met Tyr  His Thr Gly Asp Phe  Glu Glu Trp 
    1355                 1360                 1365             


Thr Arg  Ile Thr Ile Val Ile  Pro Arg Ser Leu Ala  Ser Ser Lys 
    1370                 1375                 1380             


Thr Arg  Phe Arg Trp Ile Gln  Glu Ser Ser Ser Gln  Lys Asn Val 
    1385                 1390                 1395             


Pro Pro  Phe Gly Leu Asp Gly  Val Tyr Ile Ser Glu  Pro Cys Pro 
    1400                 1405                 1410             


Ser Tyr  Cys Ser Gly His Gly  Asp Cys Ile Ser Gly  Val Cys Phe 
    1415                 1420                 1425             


Cys Asp  Leu Gly Tyr Thr Ala  Ala Gln Gly Thr Cys  Val Ser Asn 
    1430                 1435                 1440             


Val Pro  Asn His Asn Glu Met  Phe Asp Arg Phe Glu  Gly Lys Leu 
    1445                 1450                 1455             


Ser Pro  Leu Trp Tyr Lys Ile  Thr Gly Ala Gln Val  Gly Thr Gly 
    1460                 1465                 1470             


Cys Gly  Thr Leu Asn Asp Gly  Lys Ser Leu Tyr Phe  Asn Gly Pro 
    1475                 1480                 1485             


Gly Lys  Arg Glu Ala Arg Thr  Val Pro Leu Asp Thr  Arg Asn Ile 
    1490                 1495                 1500             


Arg Leu  Val Gln Phe Tyr Ile  Gln Ile Gly Ser Lys  Thr Ser Gly 
    1505                 1510                 1515             


Ile Thr  Cys Ile Lys Pro Arg  Thr Arg Asn Glu Gly  Leu Ile Val 
    1520                 1525                 1530             


Gln Tyr  Ser Asn Asp Asn Gly  Ile Leu Trp His Leu  Leu Arg Glu 
    1535                 1540                 1545             


Leu Asp  Phe Met Ser Phe Leu  Glu Pro Gln Ile Ile  Ser Ile Asp 
    1550                 1555                 1560             


Leu Pro  Gln Asp Ala Lys Thr  Pro Ala Thr Ala Phe  Arg Trp Trp 
    1565                 1570                 1575             


Gln Pro  Gln His Gly Lys His  Ser Ala Gln Trp Ala  Leu Asp Asp 
    1580                 1585                 1590             


Val Leu  Ile Gly Met Asn Asp  Ser Ser Gln Thr Gly  Phe Gln Asp 
    1595                 1600                 1605             


Lys Phe  Asp Gly Ser Ile Asp  Leu Gln Ala Asn Trp  Tyr Arg Ile 
    1610                 1615                 1620             


Gln Gly  Gly Gln Val Asp Ile  Asp Cys Leu Ser Met  Asp Thr Ala 
    1625                 1630                 1635             


Leu Ile  Phe Thr Glu Asn Ile  Gly Lys Pro Arg Tyr  Ala Glu Thr 
    1640                 1645                 1650             


Trp Asp  Phe His Val Ser Ala  Ser Thr Phe Leu Gln  Phe Glu Met 
    1655                 1660                 1665             


Ser Met  Gly Cys Ser Lys Pro  Phe Ser Asn Ser His  Ser Val Gln 
    1670                 1675                 1680             


Leu Gln  Tyr Ser Leu Asn Asn  Gly Lys Asp Trp His  Leu Val Thr 
    1685                 1690                 1695             


Glu Glu  Cys Val Pro Pro Thr  Ile Gly Cys Leu His  Tyr Thr Glu 
    1700                 1705                 1710             


Ser Ser  Ile Tyr Thr Ser Glu  Arg Phe Gln Asn Trp  Lys Arg Ile 
    1715                 1720                 1725             


Thr Val  Tyr Leu Pro Leu Ser  Thr Ile Ser Pro Arg  Thr Arg Phe 
    1730                 1735                 1740             


Arg Trp  Ile Gln Ala Asn Tyr  Thr Val Gly Ala Asp  Ser Trp Ala 
    1745                 1750                 1755             


Ile Asp  Asn Val Val Leu Ala  Ser Gly Cys Pro Trp  Met Cys Ser 
    1760                 1765                 1770             


Gly Arg  Gly Ile Cys Asp Ala  Gly Arg Cys Val Cys  Asp Arg Gly 
    1775                 1780                 1785             


Phe Gly  Gly Pro Tyr Cys Val  Pro Val Val Pro Leu  Pro Ser Ile 
    1790                 1795                 1800             


Leu Lys  Asp Asp Phe Asn Gly  Asn Leu His Pro Asp  Leu Trp Pro 
    1805                 1810                 1815             


Glu Val  Tyr Gly Ala Glu Arg  Gly Asn Leu Asn Gly  Glu Thr Ile 
    1820                 1825                 1830             


Lys Ser  Gly Thr Ser Leu Ile  Phe Lys Gly Glu Gly  Leu Arg Met 
    1835                 1840                 1845             


Leu Ile  Ser Arg Asp Leu Asp  Cys Thr Asn Thr Met  Tyr Val Gln 
    1850                 1855                 1860             


Phe Ser  Leu Arg Phe Ile Ala  Lys Ser Thr Pro Glu  Arg Ser His 
    1865                 1870                 1875             


Ser Ile  Leu Leu Gln Phe Ser  Ile Ser Gly Gly Ile  Thr Trp His 
    1880                 1885                 1890             


Leu Met  Asp Glu Phe Tyr Phe  Pro Gln Thr Thr Asn  Ile Leu Phe 
    1895                 1900                 1905             


Ile Asn  Val Pro Leu Pro Tyr  Thr Ala Gln Thr Asn  Ala Thr Arg 
    1910                 1915                 1920             


Phe Arg  Leu Trp Gln Pro Tyr  Asn Asn Gly Lys Lys  Glu Glu Ile 
    1925                 1930                 1935             


Trp Ile  Val Asp Asp Phe Ile  Ile Asp Gly Asn Asn  Val Asn Asn 
    1940                 1945                 1950             


Pro Val  Met Leu Leu Asp Thr  Phe Asp Phe Gly Pro  Arg Glu Asp 
    1955                 1960                 1965             


Asn Trp  Phe Phe Tyr Pro Gly  Gly Asn Ile Gly Leu  Tyr Cys Pro 
    1970                 1975                 1980             


Tyr Ser  Ser Lys Gly Ala Pro  Glu Glu Asp Ser Ala  Met Val Phe 
    1985                 1990                 1995             


Val Ser  Asn Glu Val Gly Glu  His Ser Ile Thr Thr  Arg Asp Leu 
    2000                 2005                 2010             


Asn Val  Asn Glu Asn Thr Ile  Ile Gln Phe Glu Ile  Asn Val Gly 
    2015                 2020                 2025             


Cys Ser  Thr Asp Ser Ser Ser  Ala Asp Pro Val Arg  Leu Glu Phe 
    2030                 2035                 2040             


Ser Arg  Asp Phe Gly Ala Thr  Trp His Leu Leu Leu  Pro Leu Cys 
    2045                 2050                 2055             


Tyr His  Ser Ser Ser His Val  Ser Ser Leu Cys Ser  Thr Glu His 
    2060                 2065                 2070             


His Pro  Ser Ser Thr Tyr Tyr  Ala Gly Thr Met Gln  Gly Trp Arg 
    2075                 2080                 2085             


Arg Glu  Val Val His Phe Gly  Lys Leu His Leu Cys  Gly Ser Val 
    2090                 2095                 2100             


Arg Phe  Arg Trp Tyr Gln Gly  Phe Tyr Pro Ala Gly  Ser Gln Pro 
    2105                 2110                 2115             


Val Thr  Trp Ala Ile Asp Asn  Val Tyr Ile Gly Pro  Gln Cys Glu 
    2120                 2125                 2130             


Glu Met  Cys Asn Gly Gln Gly  Ser Cys Ile Asn Gly  Thr Lys Cys 
    2135                 2140                 2145             


Ile Cys  Asp Pro Gly Tyr Ser  Gly Pro Thr Cys Lys  Ile Ser Thr 
    2150                 2155                 2160             


Lys Asn  Pro Asp Phe Leu Lys  Asp Asp Phe Glu Gly  Gln Leu Glu 
    2165                 2170                 2175             


Ser Asp  Arg Phe Leu Leu Met  Ser Gly Gly Lys Pro  Ser Arg Lys 
    2180                 2185                 2190             


Cys Gly  Ile Leu Ser Ser Gly  Asn Asn Leu Phe Phe  Asn Glu Asp 
    2195                 2200                 2205             


Gly Leu  Arg Met Leu Met Thr  Arg Asp Leu Asp Leu  Ser His Ala 
    2210                 2215                 2220             


Arg Phe  Val Gln Phe Phe Met  Arg Leu Gly Cys Gly  Lys Gly Val 
    2225                 2230                 2235             


Pro Asp  Pro Arg Ser Gln Pro  Val Leu Leu Gln Tyr  Ser Leu Asn 
    2240                 2245                 2250             


Gly Gly  Leu Ser Trp Ser Leu  Leu Gln Glu Phe Leu  Phe Ser Asn 
    2255                 2260                 2265             


Ser Ser  Asn Val Gly Arg Tyr  Ile Ala Leu Glu Ile  Pro Leu Lys 
    2270                 2275                 2280             


Ala Arg  Ser Gly Ser Thr Arg  Leu Arg Trp Trp Gln  Pro Ser Glu 
    2285                 2290                 2295             


Asn Gly  His Phe Tyr Ser Pro  Trp Val Ile Asp Gln  Ile Leu Ile 
    2300                 2305                 2310             


Gly Gly  Asn Ile Ser Gly Asn  Thr Val Leu Glu Asp  Asp Phe Thr 
    2315                 2320                 2325             


Thr Leu  Asp Ser Arg Lys Trp  Leu Leu His Pro Gly  Gly Thr Lys 
    2330                 2335                 2340             


Met Pro  Val Cys Gly Ser Thr  Gly Asp Ala Leu Val  Phe Ile Glu 
    2345                 2350                 2355             


Lys Ala  Ser Thr Arg Tyr Val  Val Ser Thr Asp Val  Ala Val Asn 
    2360                 2365                 2370             


Glu Asp  Ser Phe Leu Gln Ile  Asp Phe Ala Ala Ser  Cys Ser Val 
    2375                 2380                 2385             


Thr Asp  Ser Cys Tyr Ala Ile  Glu Leu Glu Tyr Ser  Val Asp Leu 
    2390                 2395                 2400             


Gly Leu  Ser Trp His Pro Leu  Val Arg Asp Cys Leu  Pro Thr Asn 
    2405                 2410                 2415             


Val Glu  Cys Ser Arg Tyr His  Leu Gln Arg Ile Leu  Val Ser Asp 
    2420                 2425                 2430             


Thr Phe  Asn Lys Trp Thr Arg  Ile Thr Leu Pro Leu  Pro Pro Tyr 
    2435                 2440                 2445             


Thr Arg  Ser Gln Ala Thr Arg  Phe Arg Trp His Gln  Pro Ala Pro 
    2450                 2455                 2460             


Phe Asp  Lys Gln Gln Thr Trp  Ala Ile Asp Asn Val  Tyr Ile Gly 
    2465                 2470                 2475             


Asp Gly  Cys Ile Asp Met Cys  Ser Gly His Gly Arg  Cys Ile Gln 
    2480                 2485                 2490             


Gly Asn  Cys Val Cys Asp Glu  Gln Trp Gly Gly Leu  Tyr Cys Asp 
    2495                 2500                 2505             


Asp Pro  Glu Thr Ser Leu Pro  Thr Gln Leu Lys Asp  Asn Phe Asn 
    2510                 2515                 2520             


Arg Ala  Pro Ser Ser Gln Asn  Trp Leu Thr Val Asn  Gly Gly Lys 
    2525                 2530                 2535             


Leu Ser  Thr Val Cys Gly Ala  Val Ala Ser Gly Met  Ala Leu His 
    2540                 2545                 2550             


Phe Ser  Gly Gly Cys Ser Arg  Leu Leu Val Thr Val  Asp Leu Asn 
    2555                 2560                 2565             


Leu Thr  Asn Ala Glu Phe Ile  Gln Phe Tyr Phe Met  Tyr Gly Cys 
    2570                 2575                 2580             


Leu Ile  Thr Pro Asn Asn Arg  Asn Gln Gly Val Leu  Leu Glu Tyr 
    2585                 2590                 2595             


Ser Val  Asn Gly Gly Ile Thr  Trp Asn Leu Leu Met  Glu Ile Phe 
    2600                 2605                 2610             


Tyr Asp  Gln Tyr Ser Lys Pro  Gly Phe Val Asn Ile  Leu Leu Pro 
    2615                 2620                 2625             


Pro Asp  Ala Lys Glu Ile Ala  Thr Arg Phe Arg Trp  Trp Gln Pro 
    2630                 2635                 2640             


Arg His  Asp Gly Leu Asp Gln  Asn Asp Trp Ala Ile  Asp Asn Val 
    2645                 2650                 2655             


Leu Ile  Ser Gly Ser Ala Asp  Gln Arg Thr Val Met  Leu Asp Thr 
    2660                 2665                 2670             


Phe Ser  Ser Ala Pro Val Pro  Gln His Glu Arg Ser  Pro Ala Asp 
    2675                 2680                 2685             


Ala Gly  Pro Val Gly Arg Ile  Ala Phe Asp Met Phe  Met Glu Asp 
    2690                 2695                 2700             


Lys Thr  Ser Val Asn Glu His  Trp Leu Phe His Asp  Asp Cys Thr 
    2705                 2710                 2715             


Val Glu  Arg Phe Cys Asp Ser  Pro Asp Gly Val Met  Leu Cys Gly 
    2720                 2725                 2730             


Ser His  Asp Gly Arg Glu Val  Tyr Ala Val Thr His  Asp Leu Thr 
    2735                 2740                 2745             


Pro Thr  Glu Gly Trp Ile Met  Gln Phe Lys Ile Ser  Val Gly Cys 
    2750                 2755                 2760             


Lys Val  Ser Glu Lys Ile Ala  Gln Asn Gln Ile His  Val Gln Tyr 
    2765                 2770                 2775             


Ser Thr  Asp Phe Gly Val Ser  Trp Asn Tyr Leu Val  Pro Gln Cys 
    2780                 2785                 2790             


Leu Pro  Ala Asp Pro Lys Cys  Ser Gly Ser Val Ser  Gln Pro Ser 
    2795                 2800                 2805             


Val Phe  Phe Pro Thr Lys Gly  Trp Lys Arg Ile Thr  Tyr Pro Leu 
    2810                 2815                 2820             


Pro Glu  Ser Leu Val Gly Asn  Pro Val Arg Phe Arg  Phe Tyr Gln 
    2825                 2830                 2835             


Lys Tyr  Ser Asp Met Gln Trp  Ala Ile Asp Asn Phe  Tyr Leu Gly 
    2840                 2845                 2850             


Pro Gly  Cys Leu Asp Asn Cys  Arg Gly His Gly Asp  Cys Leu Arg 
    2855                 2860                 2865             


Glu Gln  Cys Ile Cys Asp Pro  Gly Tyr Ser Gly Pro  Asn Cys Tyr 
    2870                 2875                 2880             


Leu Thr  His Thr Leu Lys Thr  Phe Leu Lys Glu Arg  Phe Asp Ser 
    2885                 2890                 2895             


Glu Glu  Ile Lys Pro Asp Leu  Trp Met Ser Leu Glu  Gly Gly Ser 
    2900                 2905                 2910             


Thr Cys  Thr Glu Cys Gly Ile  Leu Ala Glu Asp Thr  Ala Leu Tyr 
    2915                 2920                 2925             


Phe Gly  Gly Ser Thr Val Arg  Gln Ala Val Thr Gln  Asp Leu Asp 
    2930                 2935                 2940             


Leu Arg  Gly Ala Lys Phe Leu  Gln Tyr Trp Gly Arg  Ile Gly Ser 
    2945                 2950                 2955             


Glu Asn  Asn Met Thr Ser Cys  His Arg Pro Ile Cys  Arg Lys Glu 
    2960                 2965                 2970             


Gly Val  Leu Leu Asp Tyr Ser  Thr Asp Gly Gly Ile  Thr Trp Thr 
    2975                 2980                 2985             


Leu Leu  His Glu Met Asp Tyr  Gln Lys Tyr Ile Ser  Val Arg His 
    2990                 2995                 3000             


Asp Tyr  Ile Leu Leu Pro Glu  Asp Ala Leu Thr Asn  Thr Thr Arg 
    3005                 3010                 3015             


Leu Arg  Trp Trp Gln Pro Phe  Val Ile Ser Asn Gly  Ile Val Val 
    3020                 3025                 3030             


Ser Gly  Val Glu Arg Ala Gln  Trp Ala Leu Asp Asn  Ile Leu Ile 
    3035                 3040                 3045             


Gly Gly  Ala Glu Ile Asn Pro  Ser Gln Leu Val Asp  Thr Phe Asp 
    3050                 3055                 3060             


Asp Glu  Gly Thr Ser His Glu  Glu Asn Trp Ser Phe  Tyr Pro Asn 
    3065                 3070                 3075             


Ala Val  Arg Thr Ala Gly Phe  Cys Gly Asn Pro Ser  Phe His Leu 
    3080                 3085                 3090             


Tyr Trp  Pro Asn Lys Lys Lys  Asp Lys Thr His Asn  Ala Leu Ser 
    3095                 3100                 3105             


Ser Arg  Glu Leu Ile Ile Gln  Pro Gly Tyr Met Met  Gln Phe Lys 
    3110                 3115                 3120             


Ile Val  Val Gly Cys Glu Ala  Thr Ser Cys Gly Asp  Leu His Ser 
    3125                 3130                 3135             


Val Met  Leu Glu Tyr Thr Lys  Asp Ala Arg Ser Asp  Ser Trp Gln 
    3140                 3145                 3150             


Leu Val  Gln Thr Gln Cys Leu  Pro Ser Ser Ser Asn  Ser Ile Gly 
    3155                 3160                 3165             


Cys Ser  Pro Phe Gln Phe His  Glu Ala Thr Ile Tyr  Asn Ser Val 
    3170                 3175                 3180             


Asn Ser  Ser Ser Trp Lys Arg  Ile Thr Ile Gln Leu  Pro Asp His 
    3185                 3190                 3195             


Val Ser  Ser Ser Ala Thr Gln  Phe Arg Trp Ile Gln  Lys Gly Glu 
    3200                 3205                 3210             


Glu Thr  Glu Lys Gln Ser Trp  Ala Ile Asp His Val  Tyr Ile Gly 
    3215                 3220                 3225             


Glu Ala  Cys Pro Lys Leu Cys  Ser Gly His Gly Tyr  Cys Thr Thr 
    3230                 3235                 3240             


Gly Ala  Ile Cys Ile Cys Asp  Glu Ser Phe Gln Gly  Asp Asp Cys 
    3245                 3250                 3255             


Ser Val  Phe Ser His Asp Leu  Pro Ser Tyr Ile Lys  Asp Asn Phe 
    3260                 3265                 3270             


Glu Ser  Ala Arg Val Thr Glu  Ala Asn Trp Glu Thr  Ile Gln Gly 
    3275                 3280                 3285             


Gly Val  Ile Gly Ser Gly Cys  Gly Gln Leu Ala Pro  Tyr Ala His 
    3290                 3295                 3300             


Gly Asp  Ser Leu Tyr Phe Asn  Gly Cys Gln Ile Arg  Gln Ala Ala 
    3305                 3310                 3315             


Thr Lys  Pro Leu Asp Leu Thr  Arg Ala Ser Lys Ile  Met Phe Val 
    3320                 3325                 3330             


Leu Gln  Ile Gly Ser Met Ser  Gln Thr Asp Ser Cys  Asn Ser Asp 
    3335                 3340                 3345             


Leu Ser  Gly Pro His Ala Val  Asp Lys Ala Val Leu  Leu Gln Tyr 
    3350                 3355                 3360             


Ser Val  Asn Asn Gly Ile Thr  Trp His Val Ile Ala  Gln His Gln 
    3365                 3370                 3375             


Pro Lys  Asp Phe Thr Gln Ala  Gln Arg Val Ser Tyr  Asn Val Pro 
    3380                 3385                 3390             


Leu Glu  Ala Arg Met Lys Gly  Val Leu Leu Arg Trp  Trp Gln Pro 
    3395                 3400                 3405             


Arg His  Asn Gly Thr Gly His  Asp Gln Trp Ala Leu  Asp His Val 
    3410                 3415                 3420             


Glu Val  Val Leu Val Ser Thr  Arg Lys Gln Asn Tyr  Met Met Asn 
    3425                 3430                 3435             


Phe Ser  Arg Gln His Gly Leu  Arg His Phe Tyr Asn  Arg Arg Arg 
    3440                 3445                 3450             


Arg Ser  Leu Arg Arg Tyr Pro  
    3455                 3460 


<210>  3
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Manganese superoxide dismutase (MnSOD) forward primer

<400>  3
gctgcaccac agcaagca                                                     18


<210>  4
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Manganese superoxide dismutase (MnSOD) reverse primer

<400>  4
tcggtggcgt tgagattgt                                                    19


<210>  5
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reelin forward primer

<400>  5
gccacgccac aatggaa                                                      17


<210>  6
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reelin reverse primer

<400>  6
cgacctccac atggtccaa                                                    19


<210>  7
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Glutamate decarboxylase 1 (Brain, 67 kDa; Gad-1/67) forward 
       primer

<400>  7
cgcttggctt tggaaccgac aa                                                22


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Glutamate decarboxylase 1 (Brain, 67 kDa; Gad-1/67) reverse 
       primer

<400>  8
gaatgctccg taaacagtcg tgc                                               23


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neurexin 1 (Nrxn1) forward primer

<400>  9
accgtgcctt agcaatcctt gc                                                22


<210>  10
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neurexin 1 (Nrxn1) reverse primer

<400>  10
gtcgtagctc aaaaccgttg cc                                                22


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neuroligin 2 (Nlgn 2) forward primer

<400>  11
cgatgtcatg ctcagcgcag ta                                                22


<210>  12
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Neuroligin 2 (Nlgn 2) reverse primer

<400>  12
ccacactacc tcttcaaagc gg                                                22


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta-Actin forward primer

<400>  13
cagcagatgt ggatcagcaa g                                                 21


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Beta-Actin reverse primer

<400>  14
gcatttgcgg tggacgat                                                     18


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mmu-miR-137-5p primer sequence

<400>  15
acgggtattc ttgggtggat aat                                               23


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mmu-miR-137-3p primer sequence

<400>  16
ttattgctta agaatacgcg tag                                               23


<210>  17
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mmu-miR-181a primer sequence

<400>  17
aacattcaac gctgtcggtg agt                                               23


<210>  18
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mmu-miR-128-1-5p primer sequence

<400>  18
cggggccgta gcactgtctg a                                                 21


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mmu-miR-128-3p primer sequence

<400>  19
tcacagtgaa ccggtctctt t                                                 21


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mmu-miR-138 primer sequence

<400>  20
agctggtgtt gtgaatcagg ccg                                               23


<210>  21
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mmu-miR-200c primer sequence

<400>  21
taatactgcc gggtaatgat gga                                               23


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  small nucleolar RNA 202 (snoRNA-202) internal forward primer

<400>  22
agtacttttg aacccttttc ca                                                22


<210>  23
<211>  11673
<212>  DNA
<213>  Mus musculus

<400>  23
ggggcgtcgc gtgcacaccg gcggcggcgg cgctcggagg cggacgacgc gctctcggcg       60

cccgcggccc cggttccccc cgcgctctcg ctccggcggc ccaaagtaac ttcgggagcc      120

tcggtctccc gctaacttcc ccccgcgggc tcggttgccc ggacccgctc ggctcgagcc      180

cgccgccggc tcgccttccc cgcacgcggc tcctccgtgc cggtgcctcc gaaagtggat      240

gagagagcgc gcggggcgcg cggcggcacg gagcgcggcg gcatggagcg cggctgctgg      300

gcgccgcggg ctctcgtcct ggccgtgctg ctgctgctgg cgacgctgag ggcgcgcgcg      360

gccaccggct actacccgcg cttctcgcct ttctttttcc tgtgcaccca ccacggggag      420

ctggaagggg atggggagca gggcgaggtg ctcatttccc tgcacattgc gggcaacccc      480

acctactacg taccgggaca ggaataccat gttacaattt caacaagcac cttctttgat      540

ggcttgctgg tgacgggact ctatacctcg acaagcatcc agtcttctca gagcattgga      600

ggctccagcg cctttggatt cgggatcatg tccgaccacc agtttggtaa ccagtttatg      660

tgcagtgtgg tggcctctca tgtgagtcac ctgcctacaa ccaacctcag ctttgtctgg      720

attgccccac cagctggcac aggctgtgtg aatttcatgg ctactgcaac acataggggc      780

caggtgattt tcaaagacgc actggcccag cagctgtgtg aacaaggagc tcccacagag      840

gccactgctt actcgcacct tgctgaaata cacagtgaca gtgtgatcct acgagatgac      900

tttgactcct accagcaact ggaattgaac cccaacatat gggttgaatg cagcaactgt      960

gagatgggag agcagtgtgg caccatcatg catggcaatg ctgtcacctt ctgtgagccg     1020

tacggccctc gagagctgac caccacatgc ctgaacacaa caacagcatc tgtcctccag     1080

ttttccattg ggtcaggatc atgtcgattt agttactctg accccagcat cactgtgtca     1140

tacgccaaga acaataccgc tgattggatt cagctggaga aaattagagc cccttccaat     1200

gtgagcacag tcatccacat cctgtacctc cccgaggaag ccaaagggga gagcgtgcag     1260

ttccagtgga aacaggacag cctgcgagtg ggtgaggtgt atgaggcctg ctgggccctg     1320

gataacatcc tggtcatcaa ttcagcccac agagaagtcg ttctggagga caacctcgac     1380

ccggtcgaca cgggcaactg gctcttcttc cctggagcaa cggtcaagca tagctgtcag     1440

tcagatggga actccattta tttccatgga aatgaaggca gcgagttcaa ttttgccacc     1500

acccgggatg tagatctttc tacagaggat attcaagagc agtggtcaga agaatttgag     1560

agccagccca caggatggga tatcttggga gcagtagttg gtgcagactg tggaaccgta     1620

gaatcaggac tatcactggt gttcctcaaa gatggagaga ggaagctttg caccccctac     1680

atggatacaa ctggttatgg caacctgagg ttctacttcg ttatgggagg aatctgtgac     1740

cctggagtct ctcatgaaaa cgatatcatc ttatatgcaa agattgaagg aagaaaagaa     1800

cacattgcac tggacactct tacctattct tcctataagg ttccgtcttt ggtttctgtg     1860

gtcatcaacc ctgaacttca gacacctgcc accaaatttt gtctcaggca aaagagccac     1920

caagggtata atcggaatgt ctgggctgtg gacttcttcc atgtgctgcc cgttctccct     1980

tcaacaatgt ctcacatgat ccagttttct attaatttgg gatgcggcac acaccagcct     2040

gggaacagcg tcagcttgga gttttctact aaccatggac ggtcctggtc cctactccac     2100

actgagtgct tgccggagat ctgtgcaggc ccccacctcc cccacagcac tgtctactcc     2160

tcagaaaact acagcgggtg gaaccgaatc acgattcctc tccctaatgc agcactcacc     2220

cgagacacca ggattcgctg gagacaaaca ggcccaatcc tgggaaatat gtgggcaatt     2280

gataatgttt atataggtcc ttcgtgtctc aaattctgtt ctggcagagg acaatgcact     2340

cggcatggct gcaagtgtga cccaggattt tctggcccag cttgtgagat ggcatctcag     2400

acattcccaa tgtttatttc ggaaagcttt ggcagtgcca gactttcctc ttaccataac     2460

ttttactcta tccgtggtgc tgaagtcagc tttggttgtg gtgtcttagc cagtggtaag     2520

gctctggttt tcaacaaaga tgggaggcgg cagctaatca cgtcctttct ggacagctcg     2580

cagtccaggt ttcttcagtt tacactgagg ctggggagca agtctgtgct gagcacgtgc     2640

agagcccctg accagccggg ggagggagtc ctgctgcact attcatatga caacgggata     2700

acatggaaac tcctggagca ctattcctac gtcaactacc acgagcccag aataatctct     2760

gtagagctac cggatgatgc aagacagttt ggaatccagt tcagatggtg gcagccttac     2820

cattcttccc aaggagaaga cgtgtgggcc attgatgaga ttgtcatgac ctcagtcctg     2880

ttcaacagca tcagtctcga ctttaccaat cttgtggaag tcactcaatc cctgggattc     2940

taccttggca atgttcaacc atactgtggc catgactgga cgctttgttt tacgggagat     3000

tctaaacttg cctcaagcat gcgctatgtg gaaacacagt ccatgcagat cggagcatcc     3060

tatatgattc agttcagcct agtgatggga tgtggccaga aatacactcc tcacatggac     3120

aaccaggtga agctggagta ctcagccaac cacggcctta catggcacct tgtacaagaa     3180

gaatgccttc ccagtatgcc aagctgccag gaatttacat ctgccagcat ttaccatgcc     3240

agcgagttca cacagtggag aagagtcact gttgttcttc cccagaaaac atggtccggt     3300

gccacccgct tccgttggag tcagagctat tacacagccc aggatgagtg ggctttagac     3360

aacatttaca ttgggcagca gtgccccaac atgtgcagtg ggcatggctc atgtgaccat     3420

ggcgtgtgca ggtgtgacca gggataccag ggcactgaat gccacccaga agctgcactt     3480

ccttccacga ttatgtcaga ttttgagaac ccgagcagtt gggaatcaga ctggcaggaa     3540

gttattgggg gagaagttgt aaagcctgag caaggctgtg gagtcgtgtc ttctggatct     3600

tctctgtact tcagcaaggc tgggaagagg cagctggtga gctgggacct ggacacatcc     3660

tgggtggact ttgtccagtt ctacatccag ataggaggag agagtgctgc atgcaacaag     3720

cctgacagca gagaggaggg cattctgctc cagtatagca acaacggggg catccagtgg     3780

cacctgctgg cagagatgta cttctcagac ttcagcaaac ccagatttgt ctacctggag     3840

ctcccagctg ctgggaagac cccttgtacc aggttccgct ggtggaagcc tgtgttctcg     3900

ggggaggact atgaccagtg ggccgttgat gatatcatca ttctgtcaga gaagcagaag     3960

caggttatcc cagttgtcaa cccaactttg ccccagaact tctatgagaa gccagctttc     4020

gattacccta tgaaccaaat gagtgtgtgg ctaatgttgg ccaatgaagg catggctaaa     4080

aacgacagct tctgtgcgac cacgccgtca gccatggtgt ttggaaagtc agatggagac     4140

cggtttgcag taactcgaga tctgaccctg aaacctggat atgtgctgca gttcaagcta     4200

aacataggct gcaccagcca gttcagcagc actgccccgg ttctcctgca gtattcacat     4260

gatgccggca tgtcgtggtt tctgttgaag gaaggatgct tcccagcgtc agcagccaaa     4320

ggatgtgaag ggaactccag ggaattgagt gagcctactg tctattatac tggggacttc     4380

gaagaatgga ctagaatcac cattgccatt ccaaggtccc ttgcatccag caagaccaga     4440

ttccgatgga tccaagagag cagctctcag aagaatgtgc ccccgtttgg cttagatggg     4500

gtgtacatat ctgagccttg tcccagttac tgcagtggcc atggagactg catctcgggg     4560

gtgtgttttt gtgacctggg gtacacagct gcacaaggaa cctgtgtgtc aaacacccct     4620

aaccacagtg agatgttcga caggtttgag gggaagctaa gcccactgtg gtacaaaatc     4680

accgggggtc aggttggcac gggctgtggc accctcaatg acggcaggtc cctctacttt     4740

aatggccttg ggaaaaggga agccaggaca gtcccactgg acaccaggaa tatcagtctt     4800

gttcagtttt atatacaaat tggaagtaaa acatcaggga ttacgtacat caccccacgg     4860

gctagatatg aggggcttgt tgttcagtat tccaatgata atgggatact ttggcatttg     4920

ctgagagagt tggatttcat gtcattcctg gagccacaga tcatttccat tgacctgccc     4980

cgggaagcaa agacacctgc cacagctttc cggtggtggc agccgcagca tgggaagcat     5040

tcggcccagt gggctttggg tgatgtcctt ataggagtga atgacagctc tcaaactgga     5100

tttcaagata aattggatgg ctccatagac ttgcaagcca actggtatcg aatccaggga     5160

ggccaagttg atatcgactg cctctctatg gacactgccc ttatattcac tgaaaacata     5220

ggaaaccctc gctatgctga gacctgggac ttccatgtgt cagagtcaag cttcttacag     5280

tgggaaatga acatgggctg cagcaagcct ttcagtggtg cccacggcat acagctccag     5340

tactctctga acaacggcaa ggactggcag cttgtcaccg aagagtgtgt ccctccaacc     5400

attgggtgcg tgcactacac agagagttca acttacacat cagaaagatt ccagaactgg     5460

aggcgggtca cggtctacct gccactcgcc accaattctc ccaggactcg gttcagatgg     5520

attcagacca actatactgt tggagcagat tcctgggcta ttgataatgt catcctggcc     5580

tcgggctgtc cttggatgtg ctcaggacga gggatctgtg attcggggcg ctgtgtgtgt     5640

gaccggggct tcggtggacc cttctgtgtt cctgttgttc ctcttccctc cattctaaaa     5700

gatgatttca atgggaactt acatcctgac ctttggcctg aagtgtacgg ggcagagagg     5760

ggcaatctga atggcgaaac catcaaatcc ggaacatgtc tgatctttaa aggggaggga     5820

ctaagaatgc ttatttccag agatctagat tgtaccaata ctatgtatgt ccagttctct     5880

ctccgattta tagcgaaagg taccccagag aggtctcact ccatccttct acagttctct     5940

gtcagtggag gagtcacctg gcacctgatg gatgaattct acttccctca aacgaccagc     6000

atacttttca tcaatgttcc cttaccatac ggtgcccaaa ccaacgctac aagattcaga     6060

ctctggcaac cgtacaataa tggtaagaaa gaagaaatct ggatcattga tgactttatt     6120

attgatggaa acaatttgaa caaccccgtg ctgctgctgg acacgttcga ctttgggccc     6180

agggaagaca attggttttt ctatccgggt ggtaatatcg gactttactg cccgtattct     6240

tcaaagggag ctcctgagga ggattcggcc atggtgtttg tttcaaacga agttggagaa     6300

cactccatta ccacacgaga cctaagtgtg aacgagaaca ccatcattca atttgagatc     6360

aatgttggct gctccactga tagttcttct gctgatccgg tcagactgga attctcaagg     6420

gactttggag ccacctggca cctgctgctg cctctctgct accacagcag cagcctcgtc     6480

agctccttat gctccactga gcatcacccg agcagcacct actacgcggg gaccacccag     6540

ggctggcggc gggaggtcgt gcacttcgga aagctgcacc tttgtggatc tgtgcgtttc     6600

cgttggtacc agggatttta tcctgctggc tctcagccgg tcacatgggc cattgacaat     6660

gtctacattg gtccccagtg tgaagagatg tgctatgggc acgggagctg catcaatgga     6720

accaagtgta tatgtgaccc gggctactct gggccaacct gtaaaataag caccaaaaat     6780

cctgattttc tcaaagacga ctttgaaggt caactggaat ccgatcgatt cttactgatg     6840

agcggtggga agccgtctcg taagtgtggc atcctttcca gtgggaacaa cctcttcttc     6900

aatgaggacg gcttgcgcat gctagtaaca cgggacctgg atttatcaca tgcaaggttt     6960

gtgcagttct tcatgagact gggatgtggt aaaggtgttc cagaccccag gagccagccc     7020

gtgcttctgc agtactccct caatggcggc ctctcctgga gtcttcttca agagttcctc     7080

ttcagcaact ccagcaatgt gggcaggtac attgccctgg aaatgcccct gaaagcccgt     7140

tctggttcga cacgcctccg ctggtggcag ccatctgaaa atgggcactt ctatagcccc     7200

tgggtgatcg accagattct tattggagga aatatctctg gtaatacagt cttagaagat     7260

gatttctcaa ctctggacag cagaaagtgg ctgcttcacc caggaggcac caagatgcct     7320

gtgtgtggct ccacaggcga tgccctggtc tttattgaaa aggccagcac ccgttacgtg     7380

gtcacgacag acatcgctgt gaatgaggac tcattcctac agatagactt tgctgcctcc     7440

tgctcagtca cagactcctg ctatgctatt gaactggagt actcggtgga tctcggtctg     7500

tcgtggcacc cgctggtgag ggactgcctg cctaccaatg ttgagtgtag tcgttaccac     7560

ctgcagcgga tcctggtgtc agatactttc aacaagtgga ccagaatcac tctgcccctg     7620

ccttcctaca ccaggtctca agccactcgt ttccgctggc atcagccagc gccttttgac     7680

aagcagcaga cctgggcaat agataatgtc tatattgggg atggttgcct agacatgtgc     7740

agtggccacg ggagatgcgt ccagggaagc tgtgtctgtg atgaacagtg gggaggcctg     7800

tactgtgatg agcctgagac ctcccttccc acccagctca aagacaactt caaccgagcc     7860

ccctccaacc agaactggct gactgtgagc ggtgggaagc tgagtacagt gtgtggggct     7920

gtggcttccg gcctggctct ccatttcagt gggggctgca gccgattgtt agtcactgtg     7980

gatctgaacc tcaccaatgc tgagtttatc cagttttact ttatgtatgg atgcctcatt     8040

acgccgagca accgtaacca gggagtcctg ctggagtact ctgtcaatgg aggcatcacc     8100

tggaacttgc tgatggagat tttctatgac cagtacagca aacctggatt tgtgaatatc     8160

cttctccctc ctgatgctaa agagattgcc actcgcttcc gatggtggca gccacgacat     8220

gatggccttg accagaatga ctgggccatt gacaatgtcc tcatctcggg ctctgcggac     8280

cagaggacag tcatgctgga cacctttagc agcgccccag taccacagca tgagcgctcc     8340

cccgcagacg ctggccctgt tggaagaatt gcttttgaaa tgttcttaga agacaaaact     8400

tcagtgaatg agaattggct cttccatgat gactgtacag tggaaagatt ctgtgactcg     8460

ccagatggtg tcatgctctg tggcagccat gatggacgag aggtgtatgc agtgactcat     8520

gacctgacgc ccactgagaa ctggatcatg cagttcaaga tctctgttgg atgcaaagtg     8580

cctgaaaaaa ttgcccagaa tcaaattcac gtgcagtttt ctactgactt tggcgtgagc     8640

tggagttatt tagtccctca gtgcttaccc gccgacccaa agtgttctgg aagcgtttct     8700

caaccgtctg tgttcttccc aactgaaggg tggaaaagga tcacctaccc gcttcctgaa     8760

agcttaacgg ggaatcctgt aagatttagg ttctaccaaa agtactcaga tgtgcagtgg     8820

gcaattgaca atttctacct tggccctgga tgtttggaca actgtggagg ccacggagac     8880

tgcctaaagg aacagtgtat ctgtgaccca ggctactcag ggccaaactg ctacttaact     8940

cacagcctga agactttcct gaaggagcgc tttgacagtg aggagatcaa gcctgactta     9000

tggatgtcct tggaaggcgg aagcacttgt acagagtgcg gggtcctcgc cgagaacact     9060

gcactctatt ttgggggatc cactgtgaga caagctatta ctcaagactt agatctcaga     9120

ggtgcaaaat tcctgcagta ctggggacgt atcggcagtg agaacaacat gacatcttgc     9180

catcggcctg tctgccggaa ggaaggcgtg ctgctggact tctctacgga tggaggaatc     9240

acttggacct tgcttcacga gatggatttc cagaaataca tttctgtgag gcacgactac     9300

atcctcctgc ctgagggggc cctcaccaac acaactcgac ttcgctggtg gcagcctttt     9360

gtcatcagca atgggctcgt ggtttccggg gtggagcgtg cgcagtgggc actggacaac     9420

attctgattg gtggagcaga aatcaatcca agccaactgg tggacacttt cgatgacgaa     9480

ggctcctccc atgaagaaaa ctggagtttt taccctaatg cagtaaggac agcaggattc     9540

tgtggcaacc catccttcca cctctactgg ccaaataaaa agaaggacaa gacccacaat     9600

gcactctcct cccgagagct cattatacag ccaggataca tgatgcaatt taaaattgtg     9660

gtgggttgtg aagccacttc atgtggtgac cttcattccg tgatgctgga gtacaccaag     9720

gatgcaaggt ccgattcctg gcagctcgtg cagacccagt gcctaccttc ctcttccaat     9780

agcattggct gctccccgtt ccagttccat gaagccacca tttataatgc tgtcaacagc     9840

tcaagctgga agaggatcac catccagctc ccagaccacg tctcgtcaag tgccacacag     9900

ttccgctgga tccagaaggg agaagaaacc gagaagcaaa gctgggccat cgaccacgtg     9960

tacatcggag aggcttgtcc caagctctgc agcgggcatg gctactgcac cacaggggcc    10020

gtctgcatct gcgatgaaag cttccaaggt gacgactgct ctgtcttcag tcacgagctt    10080

cctagttaca ttaaagataa ttttgaatca gcaagagtca ctgaagccaa ctgggaaacc    10140

atccagggtg gagtgatcgg aagtggctgt gggcagctgg cgccctatgc ccatggagat    10200

tcgctctact ttaatggttg tcagataagg caagctgcca ccaagccact ggacctcact    10260

cgagcaagca aaattatgtt tgtcttgcaa attgggagcc cagcccagac agacagttgc    10320

aacagcgacc tcagcggccc ccacaccgtg gacaaagcag tactgctgca gtacagtgtc    10380

aacaatggca tcacctggca cgtcatcgct cagcaccagc cgaaggactt cacacaagct    10440

cagcgggtgt cttacaacgt ccccctggaa gctcggatga aaggagttct actgcgctgg    10500

tggcagccac gccacaatgg aacaggtcat gatcaatggg ctttggacca tgtggaggtc    10560

gtcctagtaa gcactcgcaa acaaaattac atgatgaatt tttcacggca acatgggctc    10620

aggcacttct acaacagaag acgaaggtcg cttaggcgat acccatgaag aatccaagtt    10680

tatttccctt tccagcgtac aatgtgtccc ttcctggttt tttgaaacac ctctcactgc    10740

atctgatatc aggaaacaaa gatgaaggac ttggcgaaca gaaagccctt cgagatcttg    10800

tgtaccccac cttcccacac tgtgagctaa tgatgtgtgg tttctctgca cataagtaaa    10860

tgtcttcacg tcagtgcgtc cgtggaaatt gtgatctgtt gtaatatcag ttacagtggc    10920

agtattgaga ataagaaata gtttaacagg aaaaaacgtt taagcacaaa catttttaag    10980

atcttatgtt ttaagtggca ttttagcaca gtatttaaca ttgttggtca ccgagctatt    11040

taagtagact gtatttcagc tctgtctctt gtttaatatg aataagttct cgtcgtttgt    11100

cctttatgta ttcttctcta ccgtataaca cactgaaact gtatctactt gctgtgttgc    11160

aatattttgc tgctggactt tgacctactt gtattatgca gaaagttaat gcagatacct    11220

attcaagatg ataactgtaa agacactgct gtctccttaa tatgctcctt aacacgtatg    11280

ttgatgtagc atcattttgt ggataggaaa aaaaatgttt gaccttcaga tattttctac    11340

ttaaaaaatt gtggatgaac gccctatctc cctcccacag tgagtcccca ttaccttgtc    11400

taaaacaatt ttttaatgtg ttctgtggcc gttttactga cagtaactgc catttcgtgt    11460

ctgtggtaac aaagtgactt gtaaaatggt ggatgtttcc ctcactgtgt tctcttcgtg    11520

ggttgtttcc ttgtgggtca tagtcatacc ttctgatgag gtggagccaa caccagcaaa    11580

gtatgatggc cctgtagcct ctgactagtc ctgaaacaga aggctgcact ctaggctgaa    11640

ccatgctaaa agcccatgct taaataaaaa atg                                 11673


<210>  24
<211>  3461
<212>  PRT
<213>  Mus musculus

<400>  24

Met Glu Arg Gly Cys Trp Ala Pro Arg Ala Leu Val Leu Ala Val Leu 
1               5                   10                  15      


Leu Leu Leu Ala Thr Leu Arg Ala Arg Ala Ala Thr Gly Tyr Tyr Pro 
            20                  25                  30          


Arg Phe Ser Pro Phe Phe Phe Leu Cys Thr His His Gly Glu Leu Glu 
        35                  40                  45              


Gly Asp Gly Glu Gln Gly Glu Val Leu Ile Ser Leu His Ile Ala Gly 
    50                  55                  60                  


Asn Pro Thr Tyr Tyr Val Pro Gly Gln Glu Tyr His Val Thr Ile Ser 
65                  70                  75                  80  


Thr Ser Thr Phe Phe Asp Gly Leu Leu Val Thr Gly Leu Tyr Thr Ser 
                85                  90                  95      


Thr Ser Ile Gln Ser Ser Gln Ser Ile Gly Gly Ser Ser Ala Phe Gly 
            100                 105                 110         


Phe Gly Ile Met Ser Asp His Gln Phe Gly Asn Gln Phe Met Cys Ser 
        115                 120                 125             


Val Val Ala Ser His Val Ser His Leu Pro Thr Thr Asn Leu Ser Phe 
    130                 135                 140                 


Val Trp Ile Ala Pro Pro Ala Gly Thr Gly Cys Val Asn Phe Met Ala 
145                 150                 155                 160 


Thr Ala Thr His Arg Gly Gln Val Ile Phe Lys Asp Ala Leu Ala Gln 
                165                 170                 175     


Gln Leu Cys Glu Gln Gly Ala Pro Thr Glu Ala Thr Ala Tyr Ser His 
            180                 185                 190         


Leu Ala Glu Ile His Ser Asp Ser Val Ile Leu Arg Asp Asp Phe Asp 
        195                 200                 205             


Ser Tyr Gln Gln Leu Glu Leu Asn Pro Asn Ile Trp Val Glu Cys Ser 
    210                 215                 220                 


Asn Cys Glu Met Gly Glu Gln Cys Gly Thr Ile Met His Gly Asn Ala 
225                 230                 235                 240 


Val Thr Phe Cys Glu Pro Tyr Gly Pro Arg Glu Leu Thr Thr Thr Cys 
                245                 250                 255     


Leu Asn Thr Thr Thr Ala Ser Val Leu Gln Phe Ser Ile Gly Ser Gly 
            260                 265                 270         


Ser Cys Arg Phe Ser Tyr Ser Asp Pro Ser Ile Thr Val Ser Tyr Ala 
        275                 280                 285             


Lys Asn Asn Thr Ala Asp Trp Ile Gln Leu Glu Lys Ile Arg Ala Pro 
    290                 295                 300                 


Ser Asn Val Ser Thr Val Ile His Ile Leu Tyr Leu Pro Glu Glu Ala 
305                 310                 315                 320 


Lys Gly Glu Ser Val Gln Phe Gln Trp Lys Gln Asp Ser Leu Arg Val 
                325                 330                 335     


Gly Glu Val Tyr Glu Ala Cys Trp Ala Leu Asp Asn Ile Leu Val Ile 
            340                 345                 350         


Asn Ser Ala His Arg Glu Val Val Leu Glu Asp Asn Leu Asp Pro Val 
        355                 360                 365             


Asp Thr Gly Asn Trp Leu Phe Phe Pro Gly Ala Thr Val Lys His Ser 
    370                 375                 380                 


Cys Gln Ser Asp Gly Asn Ser Ile Tyr Phe His Gly Asn Glu Gly Ser 
385                 390                 395                 400 


Glu Phe Asn Phe Ala Thr Thr Arg Asp Val Asp Leu Ser Thr Glu Asp 
                405                 410                 415     


Ile Gln Glu Gln Trp Ser Glu Glu Phe Glu Ser Gln Pro Thr Gly Trp 
            420                 425                 430         


Asp Ile Leu Gly Ala Val Val Gly Ala Asp Cys Gly Thr Val Glu Ser 
        435                 440                 445             


Gly Leu Ser Leu Val Phe Leu Lys Asp Gly Glu Arg Lys Leu Cys Thr 
    450                 455                 460                 


Pro Tyr Met Asp Thr Thr Gly Tyr Gly Asn Leu Arg Phe Tyr Phe Val 
465                 470                 475                 480 


Met Gly Gly Ile Cys Asp Pro Gly Val Ser His Glu Asn Asp Ile Ile 
                485                 490                 495     


Leu Tyr Ala Lys Ile Glu Gly Arg Lys Glu His Ile Ala Leu Asp Thr 
            500                 505                 510         


Leu Thr Tyr Ser Ser Tyr Lys Val Pro Ser Leu Val Ser Val Val Ile 
        515                 520                 525             


Asn Pro Glu Leu Gln Thr Pro Ala Thr Lys Phe Cys Leu Arg Gln Lys 
    530                 535                 540                 


Ser His Gln Gly Tyr Asn Arg Asn Val Trp Ala Val Asp Phe Phe His 
545                 550                 555                 560 


Val Leu Pro Val Leu Pro Ser Thr Met Ser His Met Ile Gln Phe Ser 
                565                 570                 575     


Ile Asn Leu Gly Cys Gly Thr His Gln Pro Gly Asn Ser Val Ser Leu 
            580                 585                 590         


Glu Phe Ser Thr Asn His Gly Arg Ser Trp Ser Leu Leu His Thr Glu 
        595                 600                 605             


Cys Leu Pro Glu Ile Cys Ala Gly Pro His Leu Pro His Ser Thr Val 
    610                 615                 620                 


Tyr Ser Ser Glu Asn Tyr Ser Gly Trp Asn Arg Ile Thr Ile Pro Leu 
625                 630                 635                 640 


Pro Asn Ala Ala Leu Thr Arg Asp Thr Arg Ile Arg Trp Arg Gln Thr 
                645                 650                 655     


Gly Pro Ile Leu Gly Asn Met Trp Ala Ile Asp Asn Val Tyr Ile Gly 
            660                 665                 670         


Pro Ser Cys Leu Lys Phe Cys Ser Gly Arg Gly Gln Cys Thr Arg His 
        675                 680                 685             


Gly Cys Lys Cys Asp Pro Gly Phe Ser Gly Pro Ala Cys Glu Met Ala 
    690                 695                 700                 


Ser Gln Thr Phe Pro Met Phe Ile Ser Glu Ser Phe Gly Ser Ala Arg 
705                 710                 715                 720 


Leu Ser Ser Tyr His Asn Phe Tyr Ser Ile Arg Gly Ala Glu Val Ser 
                725                 730                 735     


Phe Gly Cys Gly Val Leu Ala Ser Gly Lys Ala Leu Val Phe Asn Lys 
            740                 745                 750         


Asp Gly Arg Arg Gln Leu Ile Thr Ser Phe Leu Asp Ser Ser Gln Ser 
        755                 760                 765             


Arg Phe Leu Gln Phe Thr Leu Arg Leu Gly Ser Lys Ser Val Leu Ser 
    770                 775                 780                 


Thr Cys Arg Ala Pro Asp Gln Pro Gly Glu Gly Val Leu Leu His Tyr 
785                 790                 795                 800 


Ser Tyr Asp Asn Gly Ile Thr Trp Lys Leu Leu Glu His Tyr Ser Tyr 
                805                 810                 815     


Val Asn Tyr His Glu Pro Arg Ile Ile Ser Val Glu Leu Pro Asp Asp 
            820                 825                 830         


Ala Arg Gln Phe Gly Ile Gln Phe Arg Trp Trp Gln Pro Tyr His Ser 
        835                 840                 845             


Ser Gln Gly Glu Asp Val Trp Ala Ile Asp Glu Ile Val Met Thr Ser 
    850                 855                 860                 


Val Leu Phe Asn Ser Ile Ser Leu Asp Phe Thr Asn Leu Val Glu Val 
865                 870                 875                 880 


Thr Gln Ser Leu Gly Phe Tyr Leu Gly Asn Val Gln Pro Tyr Cys Gly 
                885                 890                 895     


His Asp Trp Thr Leu Cys Phe Thr Gly Asp Ser Lys Leu Ala Ser Ser 
            900                 905                 910         


Met Arg Tyr Val Glu Thr Gln Ser Met Gln Ile Gly Ala Ser Tyr Met 
        915                 920                 925             


Ile Gln Phe Ser Leu Val Met Gly Cys Gly Gln Lys Tyr Thr Pro His 
    930                 935                 940                 


Met Asp Asn Gln Val Lys Leu Glu Tyr Ser Ala Asn His Gly Leu Thr 
945                 950                 955                 960 


Trp His Leu Val Gln Glu Glu Cys Leu Pro Ser Met Pro Ser Cys Gln 
                965                 970                 975     


Glu Phe Thr Ser Ala Ser Ile Tyr His Ala Ser Glu Phe Thr Gln Trp 
            980                 985                 990         


Arg Arg Val Thr Val Val Leu Pro  Gln Lys Thr Trp Ser  Gly Ala Thr 
        995                 1000                 1005             


Arg Phe  Arg Trp Ser Gln Ser  Tyr Tyr Thr Ala Gln  Asp Glu Trp 
    1010                 1015                 1020             


Ala Leu  Asp Asn Ile Tyr Ile  Gly Gln Gln Cys Pro  Asn Met Cys 
    1025                 1030                 1035             


Ser Gly  His Gly Ser Cys Asp  His Gly Val Cys Arg  Cys Asp Gln 
    1040                 1045                 1050             


Gly Tyr  Gln Gly Thr Glu Cys  His Pro Glu Ala Ala  Leu Pro Ser 
    1055                 1060                 1065             


Thr Ile  Met Ser Asp Phe Glu  Asn Pro Ser Ser Trp  Glu Ser Asp 
    1070                 1075                 1080             


Trp Gln  Glu Val Ile Gly Gly  Glu Val Val Lys Pro  Glu Gln Gly 
    1085                 1090                 1095             


Cys Gly  Val Val Ser Ser Gly  Ser Ser Leu Tyr Phe  Ser Lys Ala 
    1100                 1105                 1110             


Gly Lys  Arg Gln Leu Val Ser  Trp Asp Leu Asp Thr  Ser Trp Val 
    1115                 1120                 1125             


Asp Phe  Val Gln Phe Tyr Ile  Gln Ile Gly Gly Glu  Ser Ala Ala 
    1130                 1135                 1140             


Cys Asn  Lys Pro Asp Ser Arg  Glu Glu Gly Ile Leu  Leu Gln Tyr 
    1145                 1150                 1155             


Ser Asn  Asn Gly Gly Ile Gln  Trp His Leu Leu Ala  Glu Met Tyr 
    1160                 1165                 1170             


Phe Ser  Asp Phe Ser Lys Pro  Arg Phe Val Tyr Leu  Glu Leu Pro 
    1175                 1180                 1185             


Ala Ala  Gly Lys Thr Pro Cys  Thr Arg Phe Arg Trp  Trp Lys Pro 
    1190                 1195                 1200             


Val Phe  Ser Gly Glu Asp Tyr  Asp Gln Trp Ala Val  Asp Asp Ile 
    1205                 1210                 1215             


Ile Ile  Leu Ser Glu Lys Gln  Lys Gln Val Ile Pro  Val Val Asn 
    1220                 1225                 1230             


Pro Thr  Leu Pro Gln Asn Phe  Tyr Glu Lys Pro Ala  Phe Asp Tyr 
    1235                 1240                 1245             


Pro Met  Asn Gln Met Ser Val  Trp Leu Met Leu Ala  Asn Glu Gly 
    1250                 1255                 1260             


Met Ala  Lys Asn Asp Ser Phe  Cys Ala Thr Thr Pro  Ser Ala Met 
    1265                 1270                 1275             


Val Phe  Gly Lys Ser Asp Gly  Asp Arg Phe Ala Val  Thr Arg Asp 
    1280                 1285                 1290             


Leu Thr  Leu Lys Pro Gly Tyr  Val Leu Gln Phe Lys  Leu Asn Ile 
    1295                 1300                 1305             


Gly Cys  Thr Ser Gln Phe Ser  Ser Thr Ala Pro Val  Leu Leu Gln 
    1310                 1315                 1320             


Tyr Ser  His Asp Ala Gly Met  Ser Trp Phe Leu Leu  Lys Glu Gly 
    1325                 1330                 1335             


Cys Phe  Pro Ala Ser Ala Ala  Lys Gly Cys Glu Gly  Asn Ser Arg 
    1340                 1345                 1350             


Glu Leu  Ser Glu Pro Thr Val  Tyr Tyr Thr Gly Asp  Phe Glu Glu 
    1355                 1360                 1365             


Trp Thr  Arg Ile Thr Ile Ala  Ile Pro Arg Ser Leu  Ala Ser Ser 
    1370                 1375                 1380             


Lys Thr  Arg Phe Arg Trp Ile  Gln Glu Ser Ser Ser  Gln Lys Asn 
    1385                 1390                 1395             


Val Pro  Pro Phe Gly Leu Asp  Gly Val Tyr Ile Ser  Glu Pro Cys 
    1400                 1405                 1410             


Pro Ser  Tyr Cys Ser Gly His  Gly Asp Cys Ile Ser  Gly Val Cys 
    1415                 1420                 1425             


Phe Cys  Asp Leu Gly Tyr Thr  Ala Ala Gln Gly Thr  Cys Val Ser 
    1430                 1435                 1440             


Asn Thr  Pro Asn His Ser Glu  Met Phe Asp Arg Phe  Glu Gly Lys 
    1445                 1450                 1455             


Leu Ser  Pro Leu Trp Tyr Lys  Ile Thr Gly Gly Gln  Val Gly Thr 
    1460                 1465                 1470             


Gly Cys  Gly Thr Leu Asn Asp  Gly Arg Ser Leu Tyr  Phe Asn Gly 
    1475                 1480                 1485             


Leu Gly  Lys Arg Glu Ala Arg  Thr Val Pro Leu Asp  Thr Arg Asn 
    1490                 1495                 1500             


Ile Ser  Leu Val Gln Phe Tyr  Ile Gln Ile Gly Ser  Lys Thr Ser 
    1505                 1510                 1515             


Gly Ile  Thr Tyr Ile Thr Pro  Arg Ala Arg Tyr Glu  Gly Leu Val 
    1520                 1525                 1530             


Val Gln  Tyr Ser Asn Asp Asn  Gly Ile Leu Trp His  Leu Leu Arg 
    1535                 1540                 1545             


Glu Leu  Asp Phe Met Ser Phe  Leu Glu Pro Gln Ile  Ile Ser Ile 
    1550                 1555                 1560             


Asp Leu  Pro Arg Glu Ala Lys  Thr Pro Ala Thr Ala  Phe Arg Trp 
    1565                 1570                 1575             


Trp Gln  Pro Gln His Gly Lys  His Ser Ala Gln Trp  Ala Leu Gly 
    1580                 1585                 1590             


Asp Val  Leu Ile Gly Val Asn  Asp Ser Ser Gln Thr  Gly Phe Gln 
    1595                 1600                 1605             


Asp Lys  Leu Asp Gly Ser Ile  Asp Leu Gln Ala Asn  Trp Tyr Arg 
    1610                 1615                 1620             


Ile Gln  Gly Gly Gln Val Asp  Ile Asp Cys Leu Ser  Met Asp Thr 
    1625                 1630                 1635             


Ala Leu  Ile Phe Thr Glu Asn  Ile Gly Asn Pro Arg  Tyr Ala Glu 
    1640                 1645                 1650             


Thr Trp  Asp Phe His Val Ser  Glu Ser Ser Phe Leu  Gln Trp Glu 
    1655                 1660                 1665             


Met Asn  Met Gly Cys Ser Lys  Pro Phe Ser Gly Ala  His Gly Ile 
    1670                 1675                 1680             


Gln Leu  Gln Tyr Ser Leu Asn  Asn Gly Lys Asp Trp  Gln Leu Val 
    1685                 1690                 1695             


Thr Glu  Glu Cys Val Pro Pro  Thr Ile Gly Cys Val  His Tyr Thr 
    1700                 1705                 1710             


Glu Ser  Ser Thr Tyr Thr Ser  Glu Arg Phe Gln Asn  Trp Arg Arg 
    1715                 1720                 1725             


Val Thr  Val Tyr Leu Pro Leu  Ala Thr Asn Ser Pro  Arg Thr Arg 
    1730                 1735                 1740             


Phe Arg  Trp Ile Gln Thr Asn  Tyr Thr Val Gly Ala  Asp Ser Trp 
    1745                 1750                 1755             


Ala Ile  Asp Asn Val Ile Leu  Ala Ser Gly Cys Pro  Trp Met Cys 
    1760                 1765                 1770             


Ser Gly  Arg Gly Ile Cys Asp  Ser Gly Arg Cys Val  Cys Asp Arg 
    1775                 1780                 1785             


Gly Phe  Gly Gly Pro Phe Cys  Val Pro Val Val Pro  Leu Pro Ser 
    1790                 1795                 1800             


Ile Leu  Lys Asp Asp Phe Asn  Gly Asn Leu His Pro  Asp Leu Trp 
    1805                 1810                 1815             


Pro Glu  Val Tyr Gly Ala Glu  Arg Gly Asn Leu Asn  Gly Glu Thr 
    1820                 1825                 1830             


Ile Lys  Ser Gly Thr Cys Leu  Ile Phe Lys Gly Glu  Gly Leu Arg 
    1835                 1840                 1845             


Met Leu  Ile Ser Arg Asp Leu  Asp Cys Thr Asn Thr  Met Tyr Val 
    1850                 1855                 1860             


Gln Phe  Ser Leu Arg Phe Ile  Ala Lys Gly Thr Pro  Glu Arg Ser 
    1865                 1870                 1875             


His Ser  Ile Leu Leu Gln Phe  Ser Val Ser Gly Gly  Val Thr Trp 
    1880                 1885                 1890             


His Leu  Met Asp Glu Phe Tyr  Phe Pro Gln Thr Thr  Ser Ile Leu 
    1895                 1900                 1905             


Phe Ile  Asn Val Pro Leu Pro  Tyr Gly Ala Gln Thr  Asn Ala Thr 
    1910                 1915                 1920             


Arg Phe  Arg Leu Trp Gln Pro  Tyr Asn Asn Gly Lys  Lys Glu Glu 
    1925                 1930                 1935             


Ile Trp  Ile Ile Asp Asp Phe  Ile Ile Asp Gly Asn  Asn Leu Asn 
    1940                 1945                 1950             


Asn Pro  Val Leu Leu Leu Asp  Thr Phe Asp Phe Gly  Pro Arg Glu 
    1955                 1960                 1965             


Asp Asn  Trp Phe Phe Tyr Pro  Gly Gly Asn Ile Gly  Leu Tyr Cys 
    1970                 1975                 1980             


Pro Tyr  Ser Ser Lys Gly Ala  Pro Glu Glu Asp Ser  Ala Met Val 
    1985                 1990                 1995             


Phe Val  Ser Asn Glu Val Gly  Glu His Ser Ile Thr  Thr Arg Asp 
    2000                 2005                 2010             


Leu Ser  Val Asn Glu Asn Thr  Ile Ile Gln Phe Glu  Ile Asn Val 
    2015                 2020                 2025             


Gly Cys  Ser Thr Asp Ser Ser  Ser Ala Asp Pro Val  Arg Leu Glu 
    2030                 2035                 2040             


Phe Ser  Arg Asp Phe Gly Ala  Thr Trp His Leu Leu  Leu Pro Leu 
    2045                 2050                 2055             


Cys Tyr  His Ser Ser Ser Leu  Val Ser Ser Leu Cys  Ser Thr Glu 
    2060                 2065                 2070             


His His  Pro Ser Ser Thr Tyr  Tyr Ala Gly Thr Thr  Gln Gly Trp 
    2075                 2080                 2085             


Arg Arg  Glu Val Val His Phe  Gly Lys Leu His Leu  Cys Gly Ser 
    2090                 2095                 2100             


Val Arg  Phe Arg Trp Tyr Gln  Gly Phe Tyr Pro Ala  Gly Ser Gln 
    2105                 2110                 2115             


Pro Val  Thr Trp Ala Ile Asp  Asn Val Tyr Ile Gly  Pro Gln Cys 
    2120                 2125                 2130             


Glu Glu  Met Cys Tyr Gly His  Gly Ser Cys Ile Asn  Gly Thr Lys 
    2135                 2140                 2145             


Cys Ile  Cys Asp Pro Gly Tyr  Ser Gly Pro Thr Cys  Lys Ile Ser 
    2150                 2155                 2160             


Thr Lys  Asn Pro Asp Phe Leu  Lys Asp Asp Phe Glu  Gly Gln Leu 
    2165                 2170                 2175             


Glu Ser  Asp Arg Phe Leu Leu  Met Ser Gly Gly Lys  Pro Ser Arg 
    2180                 2185                 2190             


Lys Cys  Gly Ile Leu Ser Ser  Gly Asn Asn Leu Phe  Phe Asn Glu 
    2195                 2200                 2205             


Asp Gly  Leu Arg Met Leu Val  Thr Arg Asp Leu Asp  Leu Ser His 
    2210                 2215                 2220             


Ala Arg  Phe Val Gln Phe Phe  Met Arg Leu Gly Cys  Gly Lys Gly 
    2225                 2230                 2235             


Val Pro  Asp Pro Arg Ser Gln  Pro Val Leu Leu Gln  Tyr Ser Leu 
    2240                 2245                 2250             


Asn Gly  Gly Leu Ser Trp Ser  Leu Leu Gln Glu Phe  Leu Phe Ser 
    2255                 2260                 2265             


Asn Ser  Ser Asn Val Gly Arg  Tyr Ile Ala Leu Glu  Met Pro Leu 
    2270                 2275                 2280             


Lys Ala  Arg Ser Gly Ser Thr  Arg Leu Arg Trp Trp  Gln Pro Ser 
    2285                 2290                 2295             


Glu Asn  Gly His Phe Tyr Ser  Pro Trp Val Ile Asp  Gln Ile Leu 
    2300                 2305                 2310             


Ile Gly  Gly Asn Ile Ser Gly  Asn Thr Val Leu Glu  Asp Asp Phe 
    2315                 2320                 2325             


Ser Thr  Leu Asp Ser Arg Lys  Trp Leu Leu His Pro  Gly Gly Thr 
    2330                 2335                 2340             


Lys Met  Pro Val Cys Gly Ser  Thr Gly Asp Ala Leu  Val Phe Ile 
    2345                 2350                 2355             


Glu Lys  Ala Ser Thr Arg Tyr  Val Val Thr Thr Asp  Ile Ala Val 
    2360                 2365                 2370             


Asn Glu  Asp Ser Phe Leu Gln  Ile Asp Phe Ala Ala  Ser Cys Ser 
    2375                 2380                 2385             


Val Thr  Asp Ser Cys Tyr Ala  Ile Glu Leu Glu Tyr  Ser Val Asp 
    2390                 2395                 2400             


Leu Gly  Leu Ser Trp His Pro  Leu Val Arg Asp Cys  Leu Pro Thr 
    2405                 2410                 2415             


Asn Val  Glu Cys Ser Arg Tyr  His Leu Gln Arg Ile  Leu Val Ser 
    2420                 2425                 2430             


Asp Thr  Phe Asn Lys Trp Thr  Arg Ile Thr Leu Pro  Leu Pro Ser 
    2435                 2440                 2445             


Tyr Thr  Arg Ser Gln Ala Thr  Arg Phe Arg Trp His  Gln Pro Ala 
    2450                 2455                 2460             


Pro Phe  Asp Lys Gln Gln Thr  Trp Ala Ile Asp Asn  Val Tyr Ile 
    2465                 2470                 2475             


Gly Asp  Gly Cys Leu Asp Met  Cys Ser Gly His Gly  Arg Cys Val 
    2480                 2485                 2490             


Gln Gly  Ser Cys Val Cys Asp  Glu Gln Trp Gly Gly  Leu Tyr Cys 
    2495                 2500                 2505             


Asp Glu  Pro Glu Thr Ser Leu  Pro Thr Gln Leu Lys  Asp Asn Phe 
    2510                 2515                 2520             


Asn Arg  Ala Pro Ser Asn Gln  Asn Trp Leu Thr Val  Ser Gly Gly 
    2525                 2530                 2535             


Lys Leu  Ser Thr Val Cys Gly  Ala Val Ala Ser Gly  Leu Ala Leu 
    2540                 2545                 2550             


His Phe  Ser Gly Gly Cys Ser  Arg Leu Leu Val Thr  Val Asp Leu 
    2555                 2560                 2565             


Asn Leu  Thr Asn Ala Glu Phe  Ile Gln Phe Tyr Phe  Met Tyr Gly 
    2570                 2575                 2580             


Cys Leu  Ile Thr Pro Ser Asn  Arg Asn Gln Gly Val  Leu Leu Glu 
    2585                 2590                 2595             


Tyr Ser  Val Asn Gly Gly Ile  Thr Trp Asn Leu Leu  Met Glu Ile 
    2600                 2605                 2610             


Phe Tyr  Asp Gln Tyr Ser Lys  Pro Gly Phe Val Asn  Ile Leu Leu 
    2615                 2620                 2625             


Pro Pro  Asp Ala Lys Glu Ile  Ala Thr Arg Phe Arg  Trp Trp Gln 
    2630                 2635                 2640             


Pro Arg  His Asp Gly Leu Asp  Gln Asn Asp Trp Ala  Ile Asp Asn 
    2645                 2650                 2655             


Val Leu  Ile Ser Gly Ser Ala  Asp Gln Arg Thr Val  Met Leu Asp 
    2660                 2665                 2670             


Thr Phe  Ser Ser Ala Pro Val  Pro Gln His Glu Arg  Ser Pro Ala 
    2675                 2680                 2685             


Asp Ala  Gly Pro Val Gly Arg  Ile Ala Phe Glu Met  Phe Leu Glu 
    2690                 2695                 2700             


Asp Lys  Thr Ser Val Asn Glu  Asn Trp Leu Phe His  Asp Asp Cys 
    2705                 2710                 2715             


Thr Val  Glu Arg Phe Cys Asp  Ser Pro Asp Gly Val  Met Leu Cys 
    2720                 2725                 2730             


Gly Ser  His Asp Gly Arg Glu  Val Tyr Ala Val Thr  His Asp Leu 
    2735                 2740                 2745             


Thr Pro  Thr Glu Asn Trp Ile  Met Gln Phe Lys Ile  Ser Val Gly 
    2750                 2755                 2760             


Cys Lys  Val Pro Glu Lys Ile  Ala Gln Asn Gln Ile  His Val Gln 
    2765                 2770                 2775             


Phe Ser  Thr Asp Phe Gly Val  Ser Trp Ser Tyr Leu  Val Pro Gln 
    2780                 2785                 2790             


Cys Leu  Pro Ala Asp Pro Lys  Cys Ser Gly Ser Val  Ser Gln Pro 
    2795                 2800                 2805             


Ser Val  Phe Phe Pro Thr Glu  Gly Trp Lys Arg Ile  Thr Tyr Pro 
    2810                 2815                 2820             


Leu Pro  Glu Ser Leu Thr Gly  Asn Pro Val Arg Phe  Arg Phe Tyr 
    2825                 2830                 2835             


Gln Lys  Tyr Ser Asp Val Gln  Trp Ala Ile Asp Asn  Phe Tyr Leu 
    2840                 2845                 2850             


Gly Pro  Gly Cys Leu Asp Asn  Cys Gly Gly His Gly  Asp Cys Leu 
    2855                 2860                 2865             


Lys Glu  Gln Cys Ile Cys Asp  Pro Gly Tyr Ser Gly  Pro Asn Cys 
    2870                 2875                 2880             


Tyr Leu  Thr His Ser Leu Lys  Thr Phe Leu Lys Glu  Arg Phe Asp 
    2885                 2890                 2895             


Ser Glu  Glu Ile Lys Pro Asp  Leu Trp Met Ser Leu  Glu Gly Gly 
    2900                 2905                 2910             


Ser Thr  Cys Thr Glu Cys Gly  Val Leu Ala Glu Asn  Thr Ala Leu 
    2915                 2920                 2925             


Tyr Phe  Gly Gly Ser Thr Val  Arg Gln Ala Ile Thr  Gln Asp Leu 
    2930                 2935                 2940             


Asp Leu  Arg Gly Ala Lys Phe  Leu Gln Tyr Trp Gly  Arg Ile Gly 
    2945                 2950                 2955             


Ser Glu  Asn Asn Met Thr Ser  Cys His Arg Pro Val  Cys Arg Lys 
    2960                 2965                 2970             


Glu Gly  Val Leu Leu Asp Phe  Ser Thr Asp Gly Gly  Ile Thr Trp 
    2975                 2980                 2985             


Thr Leu  Leu His Glu Met Asp  Phe Gln Lys Tyr Ile  Ser Val Arg 
    2990                 2995                 3000             


His Asp  Tyr Ile Leu Leu Pro  Glu Gly Ala Leu Thr  Asn Thr Thr 
    3005                 3010                 3015             


Arg Leu  Arg Trp Trp Gln Pro  Phe Val Ile Ser Asn  Gly Leu Val 
    3020                 3025                 3030             


Val Ser  Gly Val Glu Arg Ala  Gln Trp Ala Leu Asp  Asn Ile Leu 
    3035                 3040                 3045             


Ile Gly  Gly Ala Glu Ile Asn  Pro Ser Gln Leu Val  Asp Thr Phe 
    3050                 3055                 3060             


Asp Asp  Glu Gly Ser Ser His  Glu Glu Asn Trp Ser  Phe Tyr Pro 
    3065                 3070                 3075             


Asn Ala  Val Arg Thr Ala Gly  Phe Cys Gly Asn Pro  Ser Phe His 
    3080                 3085                 3090             


Leu Tyr  Trp Pro Asn Lys Lys  Lys Asp Lys Thr His  Asn Ala Leu 
    3095                 3100                 3105             


Ser Ser  Arg Glu Leu Ile Ile  Gln Pro Gly Tyr Met  Met Gln Phe 
    3110                 3115                 3120             


Lys Ile  Val Val Gly Cys Glu  Ala Thr Ser Cys Gly  Asp Leu His 
    3125                 3130                 3135             


Ser Val  Met Leu Glu Tyr Thr  Lys Asp Ala Arg Ser  Asp Ser Trp 
    3140                 3145                 3150             


Gln Leu  Val Gln Thr Gln Cys  Leu Pro Ser Ser Ser  Asn Ser Ile 
    3155                 3160                 3165             


Gly Cys  Ser Pro Phe Gln Phe  His Glu Ala Thr Ile  Tyr Asn Ala 
    3170                 3175                 3180             


Val Asn  Ser Ser Ser Trp Lys  Arg Ile Thr Ile Gln  Leu Pro Asp 
    3185                 3190                 3195             


His Val  Ser Ser Ser Ala Thr  Gln Phe Arg Trp Ile  Gln Lys Gly 
    3200                 3205                 3210             


Glu Glu  Thr Glu Lys Gln Ser  Trp Ala Ile Asp His  Val Tyr Ile 
    3215                 3220                 3225             


Gly Glu  Ala Cys Pro Lys Leu  Cys Ser Gly His Gly  Tyr Cys Thr 
    3230                 3235                 3240             


Thr Gly  Ala Val Cys Ile Cys  Asp Glu Ser Phe Gln  Gly Asp Asp 
    3245                 3250                 3255             


Cys Ser  Val Phe Ser His Glu  Leu Pro Ser Tyr Ile  Lys Asp Asn 
    3260                 3265                 3270             


Phe Glu  Ser Ala Arg Val Thr  Glu Ala Asn Trp Glu  Thr Ile Gln 
    3275                 3280                 3285             


Gly Gly  Val Ile Gly Ser Gly  Cys Gly Gln Leu Ala  Pro Tyr Ala 
    3290                 3295                 3300             


His Gly  Asp Ser Leu Tyr Phe  Asn Gly Cys Gln Ile  Arg Gln Ala 
    3305                 3310                 3315             


Ala Thr  Lys Pro Leu Asp Leu  Thr Arg Ala Ser Lys  Ile Met Phe 
    3320                 3325                 3330             


Val Leu  Gln Ile Gly Ser Pro  Ala Gln Thr Asp Ser  Cys Asn Ser 
    3335                 3340                 3345             


Asp Leu  Ser Gly Pro His Thr  Val Asp Lys Ala Val  Leu Leu Gln 
    3350                 3355                 3360             


Tyr Ser  Val Asn Asn Gly Ile  Thr Trp His Val Ile  Ala Gln His 
    3365                 3370                 3375             


Gln Pro  Lys Asp Phe Thr Gln  Ala Gln Arg Val Ser  Tyr Asn Val 
    3380                 3385                 3390             


Pro Leu  Glu Ala Arg Met Lys  Gly Val Leu Leu Arg  Trp Trp Gln 
    3395                 3400                 3405             


Pro Arg  His Asn Gly Thr Gly  His Asp Gln Trp Ala  Leu Asp His 
    3410                 3415                 3420             


Val Glu  Val Val Leu Val Ser  Thr Arg Lys Gln Asn  Tyr Met Met 
    3425                 3430                 3435             


Asn Phe  Ser Arg Gln His Gly  Leu Arg His Phe Tyr  Asn Arg Arg 
    3440                 3445                 3450             


Arg Arg  Ser Leu Arg Arg Tyr  Pro 
    3455                 3460     


