                         SEQUENCE LISTING

<110>  President and Fellows of Harvard
 
<120>  DELIVERY OF THERAPEUTIC RNAS VIA ARRDC1-MEDIATED MICROVESICLES

<130>  H0824.70227WO00

<140>  Not Yet Assigned
<141>  2017-09-29

<150>  US 62/403,678
<151>  2016-10-03

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Pro Ser Ala Pro 
1               


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Pro Pro Xaa Tyr 
1               


<210>  3
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Ala Gly Val Phe 
1               


<210>  4
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Gly Phe Leu Gly 
1               


<210>  5
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Ala Leu Ala Leu 
1               


<210>  6
<211>  922
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Thr Ala Ser Pro Arg Ser Asp Thr Ser Asn Asn His Ser Gly 
1               5                   10                  15      


Arg Leu Gln Leu Gln Val Thr Val Ser Ser Ala Lys Leu Lys Arg Lys 
            20                  25                  30          


Lys Asn Trp Phe Gly Thr Ala Ile Tyr Thr Glu Val Val Val Asp Gly 
        35                  40                  45              


Glu Ile Thr Lys Thr Ala Lys Ser Ser Ser Ser Ser Asn Pro Lys Trp 
    50                  55                  60                  


Asp Glu Gln Leu Thr Val Asn Val Thr Pro Gln Thr Thr Leu Glu Phe 
65                  70                  75                  80  


Gln Val Trp Ser His Arg Thr Leu Lys Ala Asp Ala Leu Leu Gly Lys 
                85                  90                  95      


Ala Thr Ile Asp Leu Lys Gln Ala Leu Leu Ile His Asn Arg Lys Leu 
            100                 105                 110         


Glu Arg Val Lys Glu Gln Leu Lys Leu Ser Leu Glu Asn Lys Asn Gly 
        115                 120                 125             


Ile Ala Gln Thr Gly Glu Leu Thr Val Val Leu Asp Gly Leu Val Ile 
    130                 135                 140                 


Glu Gln Glu Asn Ile Thr Asn Cys Ser Ser Ser Pro Thr Ile Glu Ile 
145                 150                 155                 160 


Gln Glu Asn Gly Asp Ala Leu His Glu Asn Gly Glu Pro Ser Ala Arg 
                165                 170                 175     


Thr Thr Ala Arg Leu Ala Val Glu Gly Thr Asn Gly Ile Asp Asn His 
            180                 185                 190         


Val Pro Thr Ser Thr Leu Val Gln Asn Ser Cys Cys Ser Tyr Val Val 
        195                 200                 205             


Asn Gly Asp Asn Thr Pro Ser Ser Pro Ser Gln Val Ala Ala Arg Pro 
    210                 215                 220                 


Lys Asn Thr Pro Ala Pro Lys Pro Leu Ala Ser Glu Pro Ala Asp Asp 
225                 230                 235                 240 


Thr Val Asn Gly Glu Ser Ser Ser Phe Ala Pro Thr Asp Asn Ala Ser 
                245                 250                 255     


Val Thr Gly Thr Pro Val Val Ser Glu Glu Asn Ala Leu Ser Pro Asn 
            260                 265                 270         


Cys Thr Ser Thr Thr Val Glu Asp Pro Pro Val Gln Glu Ile Leu Thr 
        275                 280                 285             


Ser Ser Glu Asn Asn Glu Cys Ile Pro Ser Thr Ser Ala Glu Leu Glu 
    290                 295                 300                 


Ser Glu Ala Arg Ser Ile Leu Glu Pro Asp Thr Ser Asn Ser Arg Ser 
305                 310                 315                 320 


Ser Ser Ala Phe Glu Ala Ala Lys Ser Arg Gln Pro Asp Gly Cys Met 
                325                 330                 335     


Asp Pro Val Arg Gln Gln Ser Gly Asn Ala Asn Thr Glu Thr Leu Pro 
            340                 345                 350         


Ser Gly Trp Glu Gln Arg Lys Asp Pro His Gly Arg Thr Tyr Tyr Val 
        355                 360                 365             


Asp His Asn Thr Arg Thr Thr Thr Trp Glu Arg Pro Gln Pro Leu Pro 
    370                 375                 380                 


Pro Gly Trp Glu Arg Arg Val Asp Asp Arg Arg Arg Val Tyr Tyr Val 
385                 390                 395                 400 


Asp His Asn Thr Arg Thr Thr Thr Trp Gln Arg Pro Thr Met Glu Ser 
                405                 410                 415     


Val Arg Asn Phe Glu Gln Trp Gln Ser Gln Arg Asn Gln Leu Gln Gly 
            420                 425                 430         


Ala Met Gln Gln Phe Asn Gln Arg Tyr Leu Tyr Ser Ala Ser Met Leu 
        435                 440                 445             


Ala Ala Glu Asn Asp Pro Tyr Gly Pro Leu Pro Pro Gly Trp Glu Lys 
    450                 455                 460                 


Arg Val Asp Ser Thr Asp Arg Val Tyr Phe Val Asn His Asn Thr Lys 
465                 470                 475                 480 


Thr Thr Gln Trp Glu Asp Pro Arg Thr Gln Gly Leu Gln Asn Glu Glu 
                485                 490                 495     


Pro Leu Pro Glu Gly Trp Glu Ile Arg Tyr Thr Arg Glu Gly Val Arg 
            500                 505                 510         


Tyr Phe Val Asp His Asn Thr Arg Thr Thr Thr Phe Lys Asp Pro Arg 
        515                 520                 525             


Asn Gly Lys Ser Ser Val Thr Lys Gly Gly Pro Gln Ile Ala Tyr Glu 
    530                 535                 540                 


Arg Gly Phe Arg Trp Lys Leu Ala His Phe Arg Tyr Leu Cys Gln Ser 
545                 550                 555                 560 


Asn Ala Leu Pro Ser His Val Lys Ile Asn Val Ser Arg Gln Thr Leu 
                565                 570                 575     


Phe Glu Asp Ser Phe Gln Gln Ile Met Ala Leu Lys Pro Tyr Asp Leu 
            580                 585                 590         


Arg Arg Arg Leu Tyr Val Ile Phe Arg Gly Glu Glu Gly Leu Asp Tyr 
        595                 600                 605             


Gly Gly Leu Ala Arg Glu Trp Phe Phe Leu Leu Ser His Glu Val Leu 
    610                 615                 620                 


Asn Pro Met Tyr Cys Leu Phe Glu Tyr Ala Gly Lys Asn Asn Tyr Cys 
625                 630                 635                 640 


Leu Gln Ile Asn Pro Ala Ser Thr Ile Asn Pro Asp His Leu Ser Tyr 
                645                 650                 655     


Phe Cys Phe Ile Gly Arg Phe Ile Ala Met Ala Leu Phe His Gly Lys 
            660                 665                 670         


Phe Ile Asp Thr Gly Phe Ser Leu Pro Phe Tyr Lys Arg Met Leu Ser 
        675                 680                 685             


Lys Lys Leu Thr Ile Lys Asp Leu Glu Ser Ile Asp Thr Glu Phe Tyr 
    690                 695                 700                 


Asn Ser Leu Ile Trp Ile Arg Asp Asn Asn Ile Glu Glu Cys Gly Leu 
705                 710                 715                 720 


Glu Met Tyr Phe Ser Val Asp Met Glu Ile Leu Gly Lys Val Thr Ser 
                725                 730                 735     


His Asp Leu Lys Leu Gly Gly Ser Asn Ile Leu Val Thr Glu Glu Asn 
            740                 745                 750         


Lys Asp Glu Tyr Ile Gly Leu Met Thr Glu Trp Arg Phe Ser Arg Gly 
        755                 760                 765             


Val Gln Glu Gln Thr Lys Ala Phe Leu Asp Gly Phe Asn Glu Val Val 
    770                 775                 780                 


Pro Leu Gln Trp Leu Gln Tyr Phe Asp Glu Lys Glu Leu Glu Val Met 
785                 790                 795                 800 


Leu Cys Gly Met Gln Glu Val Asp Leu Ala Asp Trp Gln Arg Asn Thr 
                805                 810                 815     


Val Tyr Arg His Tyr Thr Arg Asn Ser Lys Gln Ile Ile Trp Phe Trp 
            820                 825                 830         


Gln Phe Val Lys Glu Thr Asp Asn Glu Val Arg Met Arg Leu Leu Gln 
        835                 840                 845             


Phe Val Thr Gly Thr Cys Arg Leu Pro Leu Gly Gly Phe Ala Glu Leu 
    850                 855                 860                 


Met Gly Ser Asn Gly Pro Gln Lys Phe Cys Ile Glu Lys Val Gly Lys 
865                 870                 875                 880 


Asp Thr Trp Leu Pro Arg Ser His Thr Cys Phe Asn Arg Leu Asp Leu 
                885                 890                 895     


Pro Pro Tyr Lys Ser Tyr Glu Gln Leu Lys Glu Lys Leu Leu Phe Ala 
            900                 905                 910         


Ile Glu Glu Thr Glu Gly Phe Gly Gln Glu 
        915                 920         


<210>  7
<211>  870
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Ser Ala Ser Ser Ser Arg Ala Gly Val Ala Leu Pro Phe Glu 
1               5                   10                  15      


Lys Ser Gln Leu Thr Leu Lys Val Val Ser Ala Lys Pro Lys Val His 
            20                  25                  30          


Asn Arg Gln Pro Arg Ile Asn Ser Tyr Val Glu Val Ala Val Asp Gly 
        35                  40                  45              


Leu Pro Ser Glu Thr Lys Lys Thr Gly Lys Arg Ile Gly Ser Ser Glu 
    50                  55                  60                  


Leu Leu Trp Asn Glu Ile Ile Ile Leu Asn Val Thr Ala Gln Ser His 
65                  70                  75                  80  


Leu Asp Leu Lys Val Trp Ser Cys His Thr Leu Arg Asn Glu Leu Leu 
                85                  90                  95      


Gly Thr Ala Ser Val Asn Leu Ser Asn Val Leu Lys Asn Asn Gly Gly 
            100                 105                 110         


Lys Met Glu Asn Met Gln Leu Thr Leu Asn Leu Gln Thr Glu Asn Lys 
        115                 120                 125             


Gly Ser Val Val Ser Gly Gly Glu Leu Thr Ile Phe Leu Asp Gly Pro 
    130                 135                 140                 


Thr Val Asp Leu Gly Asn Val Pro Asn Gly Ser Ala Leu Thr Asp Gly 
145                 150                 155                 160 


Ser Gln Leu Pro Ser Arg Asp Ser Ser Gly Thr Ala Val Ala Pro Glu 
                165                 170                 175     


Asn Arg His Gln Pro Pro Ser Thr Asn Cys Phe Gly Gly Arg Ser Arg 
            180                 185                 190         


Thr His Arg His Ser Gly Ala Ser Ala Arg Thr Thr Pro Ala Thr Gly 
        195                 200                 205             


Glu Gln Ser Pro Gly Ala Arg Ser Arg His Arg Gln Pro Val Lys Asn 
    210                 215                 220                 


Ser Gly His Ser Gly Leu Ala Asn Gly Thr Val Asn Asp Glu Pro Thr 
225                 230                 235                 240 


Thr Ala Thr Asp Pro Glu Glu Pro Ser Val Val Gly Val Thr Ser Pro 
                245                 250                 255     


Pro Ala Ala Pro Leu Ser Val Thr Pro Asn Pro Asn Thr Thr Ser Leu 
            260                 265                 270         


Pro Ala Pro Ala Thr Pro Ala Glu Gly Glu Glu Pro Ser Thr Ser Gly 
        275                 280                 285             


Thr Gln Gln Leu Pro Ala Ala Ala Gln Ala Pro Asp Ala Leu Pro Ala 
    290                 295                 300                 


Gly Trp Glu Gln Arg Glu Leu Pro Asn Gly Arg Val Tyr Tyr Val Asp 
305                 310                 315                 320 


His Asn Thr Lys Thr Thr Thr Trp Glu Arg Pro Leu Pro Pro Gly Trp 
                325                 330                 335     


Glu Lys Arg Thr Asp Pro Arg Gly Arg Phe Tyr Tyr Val Asp His Asn 
            340                 345                 350         


Thr Arg Thr Thr Thr Trp Gln Arg Pro Thr Ala Glu Tyr Val Arg Asn 
        355                 360                 365             


Tyr Glu Gln Trp Gln Ser Gln Arg Asn Gln Leu Gln Gly Ala Met Gln 
    370                 375                 380                 


His Phe Ser Gln Arg Phe Leu Tyr Gln Ser Ser Ser Ala Ser Thr Asp 
385                 390                 395                 400 


His Asp Pro Leu Gly Pro Leu Pro Pro Gly Trp Glu Lys Arg Gln Asp 
                405                 410                 415     


Asn Gly Arg Val Tyr Tyr Val Asn His Asn Thr Arg Thr Thr Gln Trp 
            420                 425                 430         


Glu Asp Pro Arg Thr Gln Gly Met Ile Gln Glu Pro Ala Leu Pro Pro 
        435                 440                 445             


Gly Trp Glu Met Lys Tyr Thr Ser Glu Gly Val Arg Tyr Phe Val Asp 
    450                 455                 460                 


His Asn Thr Arg Thr Thr Thr Phe Lys Asp Pro Arg Pro Gly Phe Glu 
465                 470                 475                 480 


Ser Gly Thr Lys Gln Gly Ser Pro Gly Ala Tyr Asp Arg Ser Phe Arg 
                485                 490                 495     


Trp Lys Tyr His Gln Phe Arg Phe Leu Cys His Ser Asn Ala Leu Pro 
            500                 505                 510         


Ser His Val Lys Ile Ser Val Ser Arg Gln Thr Leu Phe Glu Asp Ser 
        515                 520                 525             


Phe Gln Gln Ile Met Asn Met Lys Pro Tyr Asp Leu Arg Arg Arg Leu 
    530                 535                 540                 


Tyr Ile Ile Met Arg Gly Glu Glu Gly Leu Asp Tyr Gly Gly Ile Ala 
545                 550                 555                 560 


Arg Glu Trp Phe Phe Leu Leu Ser His Glu Val Leu Asn Pro Met Tyr 
                565                 570                 575     


Cys Leu Phe Glu Tyr Ala Gly Lys Asn Asn Tyr Cys Leu Gln Ile Asn 
            580                 585                 590         


Pro Ala Ser Ser Ile Asn Pro Asp His Leu Thr Tyr Phe Arg Phe Ile 
        595                 600                 605             


Gly Arg Phe Ile Ala Met Ala Leu Tyr His Gly Lys Phe Ile Asp Thr 
    610                 615                 620                 


Gly Phe Thr Leu Pro Phe Tyr Lys Arg Met Leu Asn Lys Arg Pro Thr 
625                 630                 635                 640 


Leu Lys Asp Leu Glu Ser Ile Asp Pro Glu Phe Tyr Asn Ser Ile Val 
                645                 650                 655     


Trp Ile Lys Glu Asn Asn Leu Glu Glu Cys Gly Leu Glu Leu Tyr Phe 
            660                 665                 670         


Ile Gln Asp Met Glu Ile Leu Gly Lys Val Thr Thr His Glu Leu Lys 
        675                 680                 685             


Glu Gly Gly Glu Ser Ile Arg Val Thr Glu Glu Asn Lys Glu Glu Tyr 
    690                 695                 700                 


Ile Met Leu Leu Thr Asp Trp Arg Phe Thr Arg Gly Val Glu Glu Gln 
705                 710                 715                 720 


Thr Lys Ala Phe Leu Asp Gly Phe Asn Glu Val Ala Pro Leu Glu Trp 
                725                 730                 735     


Leu Arg Tyr Phe Asp Glu Lys Glu Leu Glu Leu Met Leu Cys Gly Met 
            740                 745                 750         


Gln Glu Ile Asp Met Ser Asp Trp Gln Lys Ser Thr Ile Tyr Arg His 
        755                 760                 765             


Tyr Thr Lys Asn Ser Lys Gln Ile Gln Trp Phe Trp Gln Val Val Lys 
    770                 775                 780                 


Glu Met Asp Asn Glu Lys Arg Ile Arg Leu Leu Gln Phe Val Thr Gly 
785                 790                 795                 800 


Thr Cys Arg Leu Pro Val Gly Gly Phe Ala Glu Leu Ile Gly Ser Asn 
                805                 810                 815     


Gly Pro Gln Lys Phe Cys Ile Asp Lys Val Gly Lys Glu Thr Trp Leu 
            820                 825                 830         


Pro Arg Ser His Thr Cys Phe Asn Arg Leu Asp Leu Pro Pro Tyr Lys 
        835                 840                 845             


Ser Tyr Glu Gln Leu Arg Glu Lys Leu Leu Tyr Ala Ile Glu Glu Thr 
    850                 855                 860                 


Glu Gly Phe Gly Gln Glu 
865                 870 


<210>  8
<211>  1319
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Gln Ser Leu Arg Leu His Phe Ala Ala Arg Arg Ser Asn Thr 
1               5                   10                  15      


Tyr Pro Leu Ser Glu Thr Ser Gly Asp Asp Leu Asp Ser His Val His 
            20                  25                  30          


Met Cys Phe Lys Arg Pro Thr Arg Ile Ser Thr Ser Asn Val Val Gln 
        35                  40                  45              


Met Lys Leu Thr Pro Arg Gln Thr Ala Leu Ala Pro Leu Ile Lys Glu 
    50                  55                  60                  


Asn Val Gln Ser Gln Glu Arg Ser Ser Val Pro Ser Ser Glu Asn Val 
65                  70                  75                  80  


Asn Lys Lys Ser Ser Cys Leu Gln Ile Ser Leu Gln Pro Thr Arg Tyr 
                85                  90                  95      


Ser Gly Tyr Leu Gln Ser Ser Asn Val Leu Ala Asp Ser Asp Asp Ala 
            100                 105                 110         


Ser Phe Thr Cys Ile Leu Lys Asp Gly Ile Tyr Ser Ser Ala Val Val 
        115                 120                 125             


Asp Asn Glu Leu Asn Ala Val Asn Asp Gly His Leu Val Ser Ser Pro 
    130                 135                 140                 


Ala Ile Cys Ser Gly Ser Leu Ser Asn Phe Ser Thr Ser Asp Asn Gly 
145                 150                 155                 160 


Ser Tyr Ser Ser Asn Gly Ser Asp Phe Gly Ser Cys Ala Ser Ile Thr 
                165                 170                 175     


Ser Gly Gly Ser Tyr Thr Asn Ser Val Ile Ser Asp Ser Ser Ser Tyr 
            180                 185                 190         


Thr Phe Pro Pro Ser Asp Asp Thr Phe Leu Gly Gly Asn Leu Pro Ser 
        195                 200                 205             


Asp Ser Thr Ser Asn Arg Ser Val Pro Asn Arg Asn Thr Thr Pro Cys 
    210                 215                 220                 


Glu Ile Phe Ser Arg Ser Thr Ser Thr Asp Pro Phe Val Gln Asp Asp 
225                 230                 235                 240 


Leu Glu His Gly Leu Glu Ile Met Lys Leu Pro Val Ser Arg Asn Thr 
                245                 250                 255     


Lys Ile Pro Leu Lys Arg Tyr Ser Ser Leu Val Ile Phe Pro Arg Ser 
            260                 265                 270         


Pro Ser Thr Thr Arg Pro Thr Ser Pro Thr Ser Leu Cys Thr Leu Leu 
        275                 280                 285             


Ser Lys Gly Ser Tyr Gln Thr Ser His Gln Phe Ile Ile Ser Pro Ser 
    290                 295                 300                 


Glu Ile Ala His Asn Glu Asp Gly Thr Ser Ala Lys Gly Phe Leu Ser 
305                 310                 315                 320 


Thr Ala Val Asn Gly Leu Arg Leu Ser Lys Thr Ile Cys Thr Pro Gly 
                325                 330                 335     


Glu Val Arg Asp Ile Arg Pro Leu His Arg Lys Gly Ser Leu Gln Lys 
            340                 345                 350         


Lys Ile Val Leu Ser Asn Asn Thr Pro Arg Gln Thr Val Cys Glu Lys 
        355                 360                 365             


Ser Ser Glu Gly Tyr Ser Cys Val Ser Val His Phe Thr Gln Arg Lys 
    370                 375                 380                 


Ala Ala Thr Leu Asp Cys Glu Thr Thr Asn Gly Asp Cys Lys Pro Glu 
385                 390                 395                 400 


Met Ser Glu Ile Lys Leu Asn Ser Asp Ser Glu Tyr Ile Lys Leu Met 
                405                 410                 415     


His Arg Thr Ser Ala Cys Leu Pro Ser Ser Gln Asn Val Asp Cys Gln 
            420                 425                 430         


Ile Asn Ile Asn Gly Glu Leu Glu Arg Pro His Ser Gln Met Asn Lys 
        435                 440                 445             


Asn His Gly Ile Leu Arg Arg Ser Ile Ser Leu Gly Gly Ala Tyr Pro 
    450                 455                 460                 


Asn Ile Ser Cys Leu Ser Ser Leu Lys His Asn Cys Ser Lys Gly Gly 
465                 470                 475                 480 


Pro Ser Gln Leu Leu Ile Lys Phe Ala Ser Gly Asn Glu Gly Lys Val 
                485                 490                 495     


Asp Asn Leu Ser Arg Asp Ser Asn Arg Asp Cys Thr Asn Glu Leu Ser 
            500                 505                 510         


Asn Ser Cys Lys Thr Arg Asp Asp Phe Leu Gly Gln Val Asp Val Pro 
        515                 520                 525             


Leu Tyr Pro Leu Pro Thr Glu Asn Pro Arg Leu Glu Arg Pro Tyr Thr 
    530                 535                 540                 


Phe Lys Asp Phe Val Leu His Pro Arg Ser His Lys Ser Arg Val Lys 
545                 550                 555                 560 


Gly Tyr Leu Arg Leu Lys Met Thr Tyr Leu Pro Lys Thr Ser Gly Ser 
                565                 570                 575     


Glu Asp Asp Asn Ala Glu Gln Ala Glu Glu Leu Glu Pro Gly Trp Val 
            580                 585                 590         


Val Leu Asp Gln Pro Asp Ala Ala Cys His Leu Gln Gln Gln Gln Glu 
        595                 600                 605             


Pro Ser Pro Leu Pro Pro Gly Trp Glu Glu Arg Gln Asp Ile Leu Gly 
    610                 615                 620                 


Arg Thr Tyr Tyr Val Asn His Glu Ser Arg Arg Thr Gln Trp Lys Arg 
625                 630                 635                 640 


Pro Thr Pro Gln Asp Asn Leu Thr Asp Ala Glu Asn Gly Asn Ile Gln 
                645                 650                 655     


Leu Gln Ala Gln Arg Ala Phe Thr Thr Arg Arg Gln Ile Ser Glu Glu 
            660                 665                 670         


Thr Glu Ser Val Asp Asn Arg Glu Ser Ser Glu Asn Trp Glu Ile Ile 
        675                 680                 685             


Arg Glu Asp Glu Ala Thr Met Tyr Ser Asn Gln Ala Phe Pro Ser Pro 
    690                 695                 700                 


Pro Pro Ser Ser Asn Leu Asp Val Pro Thr His Leu Ala Glu Glu Leu 
705                 710                 715                 720 


Asn Ala Arg Leu Thr Ile Phe Gly Asn Ser Ala Val Ser Gln Pro Ala 
                725                 730                 735     


Ser Ser Ser Asn His Ser Ser Arg Arg Gly Ser Leu Gln Ala Tyr Thr 
            740                 745                 750         


Phe Glu Glu Gln Pro Thr Leu Pro Val Leu Leu Pro Thr Ser Ser Gly 
        755                 760                 765             


Leu Pro Pro Gly Trp Glu Glu Lys Gln Asp Glu Arg Gly Arg Ser Tyr 
    770                 775                 780                 


Tyr Val Asp His Asn Ser Arg Thr Thr Thr Trp Thr Lys Pro Thr Val 
785                 790                 795                 800 


Gln Ala Thr Val Glu Thr Ser Gln Leu Thr Ser Ser Gln Ser Ser Ala 
                805                 810                 815     


Gly Pro Gln Ser Gln Ala Ser Thr Ser Asp Ser Gly Gln Gln Val Thr 
            820                 825                 830         


Gln Pro Ser Glu Ile Glu Gln Gly Phe Leu Pro Lys Gly Trp Glu Val 
        835                 840                 845             


Arg His Ala Pro Asn Gly Arg Pro Phe Phe Ile Asp His Asn Thr Lys 
    850                 855                 860                 


Thr Thr Thr Trp Glu Asp Pro Arg Leu Lys Ile Pro Ala His Leu Arg 
865                 870                 875                 880 


Gly Lys Thr Ser Leu Asp Thr Ser Asn Asp Leu Gly Pro Leu Pro Pro 
                885                 890                 895     


Gly Trp Glu Glu Arg Thr His Thr Asp Gly Arg Ile Phe Tyr Ile Asn 
            900                 905                 910         


His Asn Ile Lys Arg Thr Gln Trp Glu Asp Pro Arg Leu Glu Asn Val 
        915                 920                 925             


Ala Ile Thr Gly Pro Ala Val Pro Tyr Ser Arg Asp Tyr Lys Arg Lys 
    930                 935                 940                 


Tyr Glu Phe Phe Arg Arg Lys Leu Lys Lys Gln Asn Asp Ile Pro Asn 
945                 950                 955                 960 


Lys Phe Glu Met Lys Leu Arg Arg Ala Thr Val Leu Glu Asp Ser Tyr 
                965                 970                 975     


Arg Arg Ile Met Gly Val Lys Arg Ala Asp Phe Leu Lys Ala Arg Leu 
            980                 985                 990         


Trp Ile Glu Phe Asp Gly Glu Lys  Gly Leu Asp Tyr Gly  Gly Val Ala 
        995                 1000                 1005             


Arg Glu  Trp Phe Phe Leu Ile  Ser Lys Glu Met Phe  Asn Pro Tyr 
    1010                 1015                 1020             


Tyr Gly  Leu Phe Glu Tyr Ser  Ala Thr Asp Asn Tyr  Thr Leu Gln 
    1025                 1030                 1035             


Ile Asn  Pro Asn Ser Gly Leu  Cys Asn Glu Asp His  Leu Ser Tyr 
    1040                 1045                 1050             


Phe Lys  Phe Ile Gly Arg Val  Ala Gly Met Ala Val  Tyr His Gly 
    1055                 1060                 1065             


Lys Leu  Leu Asp Gly Phe Phe  Ile Arg Pro Phe Tyr  Lys Met Met 
    1070                 1075                 1080             


Leu His  Lys Pro Ile Thr Leu  His Asp Met Glu Ser  Val Asp Ser 
    1085                 1090                 1095             


Glu Tyr  Tyr Asn Ser Leu Arg  Trp Ile Leu Glu Asn  Asp Pro Thr 
    1100                 1105                 1110             


Glu Leu  Asp Leu Arg Phe Ile  Ile Asp Glu Glu Leu  Phe Gly Gln 
    1115                 1120                 1125             


Thr His  Gln His Glu Leu Lys  Asn Gly Gly Ser Glu  Ile Val Val 
    1130                 1135                 1140             


Thr Asn  Lys Asn Lys Lys Glu  Tyr Ile Tyr Leu Val  Ile Gln Trp 
    1145                 1150                 1155             


Arg Phe  Val Asn Arg Ile Gln  Lys Gln Met Ala Ala  Phe Lys Glu 
    1160                 1165                 1170             


Gly Phe  Phe Glu Leu Ile Pro  Gln Asp Leu Ile Lys  Ile Phe Asp 
    1175                 1180                 1185             


Glu Asn  Glu Leu Glu Leu Leu  Met Cys Gly Leu Gly  Asp Val Asp 
    1190                 1195                 1200             


Val Asn  Asp Trp Arg Glu His  Thr Lys Tyr Lys Asn  Gly Tyr Ser 
    1205                 1210                 1215             


Ala Asn  His Gln Val Ile Gln  Trp Phe Trp Lys Ala  Val Leu Met 
    1220                 1225                 1230             


Met Asp  Ser Glu Lys Arg Ile  Arg Leu Leu Gln Phe  Val Thr Gly 
    1235                 1240                 1245             


Thr Ser  Arg Val Pro Met Asn  Gly Phe Ala Glu Leu  Tyr Gly Ser 
    1250                 1255                 1260             


Asn Gly  Pro Gln Ser Phe Thr  Val Glu Gln Trp Gly  Thr Pro Glu 
    1265                 1270                 1275             


Lys Leu  Pro Arg Ala His Thr  Cys Phe Asn Arg Leu  Asp Leu Pro 
    1280                 1285                 1290             


Pro Tyr  Glu Ser Phe Glu Glu  Leu Trp Asp Lys Leu  Gln Met Ala 
    1295                 1300                 1305             


Ile Glu  Asn Thr Gln Gly Phe  Asp Gly Val Asp 
    1310                 1315                 


<210>  9
<211>  955
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Thr Gly Leu Gly Glu Pro Val Tyr Gly Leu Ser Glu Asp Glu 
1               5                   10                  15      


Gly Glu Ser Arg Ile Leu Arg Val Lys Val Val Ser Gly Ile Asp Leu 
            20                  25                  30          


Ala Lys Lys Asp Ile Phe Gly Ala Ser Asp Pro Tyr Val Lys Leu Ser 
        35                  40                  45              


Leu Tyr Val Ala Asp Glu Asn Arg Glu Leu Ala Leu Val Gln Thr Lys 
    50                  55                  60                  


Thr Ile Lys Lys Thr Leu Asn Pro Lys Trp Asn Glu Glu Phe Tyr Phe 
65                  70                  75                  80  


Arg Val Asn Pro Ser Asn His Arg Leu Leu Phe Glu Val Phe Asp Glu 
                85                  90                  95      


Asn Arg Leu Thr Arg Asp Asp Phe Leu Gly Gln Val Asp Val Pro Leu 
            100                 105                 110         


Ser His Leu Pro Thr Glu Asp Pro Thr Met Glu Arg Pro Tyr Thr Phe 
        115                 120                 125             


Lys Asp Phe Leu Leu Arg Pro Arg Ser His Lys Ser Arg Val Lys Gly 
    130                 135                 140                 


Phe Leu Arg Leu Lys Met Ala Tyr Met Pro Lys Asn Gly Gly Gln Asp 
145                 150                 155                 160 


Glu Glu Asn Ser Asp Gln Arg Asp Asp Met Glu His Gly Trp Glu Val 
                165                 170                 175     


Val Asp Ser Asn Asp Ser Ala Ser Gln His Gln Glu Glu Leu Pro Pro 
            180                 185                 190         


Pro Pro Leu Pro Pro Gly Trp Glu Glu Lys Val Asp Asn Leu Gly Arg 
        195                 200                 205             


Thr Tyr Tyr Val Asn His Asn Asn Arg Thr Thr Gln Trp His Arg Pro 
    210                 215                 220                 


Ser Leu Met Asp Val Ser Ser Glu Ser Asp Asn Asn Ile Arg Gln Ile 
225                 230                 235                 240 


Asn Gln Glu Ala Ala His Arg Arg Phe Arg Ser Arg Arg His Ile Ser 
                245                 250                 255     


Glu Asp Leu Glu Pro Glu Pro Ser Glu Gly Gly Asp Val Pro Glu Pro 
            260                 265                 270         


Trp Glu Thr Ile Ser Glu Glu Val Asn Ile Ala Gly Asp Ser Leu Gly 
        275                 280                 285             


Leu Ala Leu Pro Pro Pro Pro Ala Ser Pro Gly Ser Arg Thr Ser Pro 
    290                 295                 300                 


Gln Glu Leu Ser Glu Glu Leu Ser Arg Arg Leu Gln Ile Thr Pro Asp 
305                 310                 315                 320 


Ser Asn Gly Glu Gln Phe Ser Ser Leu Ile Gln Arg Glu Pro Ser Ser 
                325                 330                 335     


Arg Leu Arg Ser Cys Ser Val Thr Asp Ala Val Ala Glu Gln Gly His 
            340                 345                 350         


Leu Pro Pro Pro Ser Val Ala Tyr Val His Thr Thr Pro Gly Leu Pro 
        355                 360                 365             


Ser Gly Trp Glu Glu Arg Lys Asp Ala Lys Gly Arg Thr Tyr Tyr Val 
    370                 375                 380                 


Asn His Asn Asn Arg Thr Thr Thr Trp Thr Arg Pro Ile Met Gln Leu 
385                 390                 395                 400 


Ala Glu Asp Gly Ala Ser Gly Ser Ala Thr Asn Ser Asn Asn His Leu 
                405                 410                 415     


Ile Glu Pro Gln Ile Arg Arg Pro Arg Ser Leu Ser Ser Pro Thr Val 
            420                 425                 430         


Thr Leu Ser Ala Pro Leu Glu Gly Ala Lys Asp Ser Pro Val Arg Arg 
        435                 440                 445             


Ala Val Lys Asp Thr Leu Ser Asn Pro Gln Ser Pro Gln Pro Ser Pro 
    450                 455                 460                 


Tyr Asn Ser Pro Lys Pro Gln His Lys Val Thr Gln Ser Phe Leu Pro 
465                 470                 475                 480 


Pro Gly Trp Glu Met Arg Ile Ala Pro Asn Gly Arg Pro Phe Phe Ile 
                485                 490                 495     


Asp His Asn Thr Lys Thr Thr Thr Trp Glu Asp Pro Arg Leu Lys Phe 
            500                 505                 510         


Pro Val His Met Arg Ser Lys Thr Ser Leu Asn Pro Asn Asp Leu Gly 
        515                 520                 525             


Pro Leu Pro Pro Gly Trp Glu Glu Arg Ile His Leu Asp Gly Arg Thr 
    530                 535                 540                 


Phe Tyr Ile Asp His Asn Ser Lys Ile Thr Gln Trp Glu Asp Pro Arg 
545                 550                 555                 560 


Leu Gln Asn Pro Ala Ile Thr Gly Pro Ala Val Pro Tyr Ser Arg Glu 
                565                 570                 575     


Phe Lys Gln Lys Tyr Asp Tyr Phe Arg Lys Lys Leu Lys Lys Pro Ala 
            580                 585                 590         


Asp Ile Pro Asn Arg Phe Glu Met Lys Leu His Arg Asn Asn Ile Phe 
        595                 600                 605             


Glu Glu Ser Tyr Arg Arg Ile Met Ser Val Lys Arg Pro Asp Val Leu 
    610                 615                 620                 


Lys Ala Arg Leu Trp Ile Glu Phe Glu Ser Glu Lys Gly Leu Asp Tyr 
625                 630                 635                 640 


Gly Gly Val Ala Arg Glu Trp Phe Phe Leu Leu Ser Lys Glu Met Phe 
                645                 650                 655     


Asn Pro Tyr Tyr Gly Leu Phe Glu Tyr Ser Ala Thr Asp Asn Tyr Thr 
            660                 665                 670         


Leu Gln Ile Asn Pro Asn Ser Gly Leu Cys Asn Glu Asp His Leu Ser 
        675                 680                 685             


Tyr Phe Thr Phe Ile Gly Arg Val Ala Gly Leu Ala Val Phe His Gly 
    690                 695                 700                 


Lys Leu Leu Asp Gly Phe Phe Ile Arg Pro Phe Tyr Lys Met Met Leu 
705                 710                 715                 720 


Gly Lys Gln Ile Thr Leu Asn Asp Met Glu Ser Val Asp Ser Glu Tyr 
                725                 730                 735     


Tyr Asn Ser Leu Lys Trp Ile Leu Glu Asn Asp Pro Thr Glu Leu Asp 
            740                 745                 750         


Leu Met Phe Cys Ile Asp Glu Glu Asn Phe Gly Gln Thr Tyr Gln Val 
        755                 760                 765             


Asp Leu Lys Pro Asn Gly Ser Glu Ile Met Val Thr Asn Glu Asn Lys 
    770                 775                 780                 


Arg Glu Tyr Ile Asp Leu Val Ile Gln Trp Arg Phe Val Asn Arg Val 
785                 790                 795                 800 


Gln Lys Gln Met Asn Ala Phe Leu Glu Gly Phe Thr Glu Leu Leu Pro 
                805                 810                 815     


Ile Asp Leu Ile Lys Ile Phe Asp Glu Asn Glu Leu Glu Leu Leu Met 
            820                 825                 830         


Cys Gly Leu Gly Asp Val Asp Val Asn Asp Trp Arg Gln His Ser Ile 
        835                 840                 845             


Tyr Lys Asn Gly Tyr Cys Pro Asn His Pro Val Ile Gln Trp Phe Trp 
    850                 855                 860                 


Lys Ala Val Leu Leu Met Asp Ala Glu Lys Arg Ile Arg Leu Leu Gln 
865                 870                 875                 880 


Phe Val Thr Gly Thr Ser Arg Val Pro Met Asn Gly Phe Ala Glu Leu 
                885                 890                 895     


Tyr Gly Ser Asn Gly Pro Gln Leu Phe Thr Ile Glu Gln Trp Gly Ser 
            900                 905                 910         


Pro Glu Lys Leu Pro Arg Ala His Thr Cys Phe Asn Arg Leu Asp Leu 
        915                 920                 925             


Pro Pro Tyr Glu Thr Phe Glu Asp Leu Arg Glu Lys Leu Leu Met Ala 
    930                 935                 940                 


Val Glu Asn Ala Gln Gly Phe Glu Gly Val Asp 
945                 950                 955 


<210>  10
<211>  757
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Asn Pro Gly Thr Arg Arg Asn Gly Ser Ser Ile Lys Ile Arg 
1               5                   10                  15      


Leu Thr Val Leu Cys Ala Lys Asn Leu Ala Lys Lys Asp Phe Phe Arg 
            20                  25                  30          


Leu Pro Asp Pro Phe Ala Lys Ile Val Val Asp Gly Ser Gly Gln Cys 
        35                  40                  45              


His Ser Thr Asp Thr Val Lys Asn Thr Leu Asp Pro Lys Trp Asn Gln 
    50                  55                  60                  


His Tyr Asp Leu Tyr Val Gly Lys Thr Asp Ser Ile Thr Ile Ser Val 
65                  70                  75                  80  


Trp Asn His Lys Lys Ile His Lys Lys Gln Gly Ala Gly Phe Leu Gly 
                85                  90                  95      


Cys Val Arg Leu Leu Ser Asn Ala Ile Ser Arg Leu Lys Asp Thr Gly 
            100                 105                 110         


Tyr Gln Arg Leu Asp Leu Cys Lys Leu Asn Pro Ser Asp Thr Asp Ala 
        115                 120                 125             


Val Arg Gly Gln Ile Val Val Ser Leu Gln Thr Arg Asp Arg Ile Gly 
    130                 135                 140                 


Thr Gly Gly Ser Val Val Asp Cys Arg Gly Leu Leu Glu Asn Glu Gly 
145                 150                 155                 160 


Thr Val Tyr Glu Asp Ser Gly Pro Gly Arg Pro Leu Ser Cys Phe Met 
                165                 170                 175     


Glu Glu Pro Ala Pro Tyr Thr Asp Ser Thr Gly Ala Ala Ala Gly Gly 
            180                 185                 190         


Gly Asn Cys Arg Phe Val Glu Ser Pro Ser Gln Asp Gln Arg Leu Gln 
        195                 200                 205             


Ala Gln Arg Leu Arg Asn Pro Asp Val Arg Gly Ser Leu Gln Thr Pro 
    210                 215                 220                 


Gln Asn Arg Pro His Gly His Gln Ser Pro Glu Leu Pro Glu Gly Tyr 
225                 230                 235                 240 


Glu Gln Arg Thr Thr Val Gln Gly Gln Val Tyr Phe Leu His Thr Gln 
                245                 250                 255     


Thr Gly Val Ser Thr Trp His Asp Pro Arg Ile Pro Ser Pro Ser Gly 
            260                 265                 270         


Thr Ile Pro Gly Gly Asp Ala Ala Phe Leu Tyr Glu Phe Leu Leu Gln 
        275                 280                 285             


Gly His Thr Ser Glu Pro Arg Asp Leu Asn Ser Val Asn Cys Asp Glu 
    290                 295                 300                 


Leu Gly Pro Leu Pro Pro Gly Trp Glu Val Arg Ser Thr Val Ser Gly 
305                 310                 315                 320 


Arg Ile Tyr Phe Val Asp His Asn Asn Arg Thr Thr Gln Phe Thr Asp 
                325                 330                 335     


Pro Arg Leu His His Ile Met Asn His Gln Cys Gln Leu Lys Glu Pro 
            340                 345                 350         


Ser Gln Pro Leu Pro Leu Pro Ser Glu Gly Ser Leu Glu Asp Glu Glu 
        355                 360                 365             


Leu Pro Ala Gln Arg Tyr Glu Arg Asp Leu Val Gln Lys Leu Lys Val 
    370                 375                 380                 


Leu Arg His Glu Leu Ser Leu Gln Gln Pro Gln Ala Gly His Cys Arg 
385                 390                 395                 400 


Ile Glu Val Ser Arg Glu Glu Ile Phe Glu Glu Ser Tyr Arg Gln Ile 
                405                 410                 415     


Met Lys Met Arg Pro Lys Asp Leu Lys Lys Arg Leu Met Val Lys Phe 
            420                 425                 430         


Arg Gly Glu Glu Gly Leu Asp Tyr Gly Gly Val Ala Arg Glu Trp Leu 
        435                 440                 445             


Tyr Leu Leu Cys His Glu Met Leu Asn Pro Tyr Tyr Gly Leu Phe Gln 
    450                 455                 460                 


Tyr Ser Thr Asp Asn Ile Tyr Met Leu Gln Ile Asn Pro Asp Ser Ser 
465                 470                 475                 480 


Ile Asn Pro Asp His Leu Ser Tyr Phe His Phe Val Gly Arg Ile Met 
                485                 490                 495     


Gly Leu Ala Val Phe His Gly His Tyr Ile Asn Gly Gly Phe Thr Val 
            500                 505                 510         


Pro Phe Tyr Lys Gln Leu Leu Gly Lys Pro Ile Gln Leu Ser Asp Leu 
        515                 520                 525             


Glu Ser Val Asp Pro Glu Leu His Lys Ser Leu Val Trp Ile Leu Glu 
    530                 535                 540                 


Asn Asp Ile Thr Pro Val Leu Asp His Thr Phe Cys Val Glu His Asn 
545                 550                 555                 560 


Ala Phe Gly Arg Ile Leu Gln His Glu Leu Lys Pro Asn Gly Arg Asn 
                565                 570                 575     


Val Pro Val Thr Glu Glu Asn Lys Lys Glu Tyr Val Arg Leu Tyr Val 
            580                 585                 590         


Asn Trp Arg Phe Met Arg Gly Ile Glu Ala Gln Phe Leu Ala Leu Gln 
        595                 600                 605             


Lys Gly Phe Asn Glu Leu Ile Pro Gln His Leu Leu Lys Pro Phe Asp 
    610                 615                 620                 


Gln Lys Glu Leu Glu Leu Ile Ile Gly Gly Leu Asp Lys Ile Asp Leu 
625                 630                 635                 640 


Asn Asp Trp Lys Ser Asn Thr Arg Leu Lys His Cys Val Ala Asp Ser 
                645                 650                 655     


Asn Ile Val Arg Trp Phe Trp Gln Ala Val Glu Thr Phe Asp Glu Glu 
            660                 665                 670         


Arg Arg Ala Arg Leu Leu Gln Phe Val Thr Gly Ser Thr Arg Val Pro 
        675                 680                 685             


Leu Gln Gly Phe Lys Ala Leu Gln Gly Ser Thr Gly Ala Ala Gly Pro 
    690                 695                 700                 


Arg Leu Phe Thr Ile His Leu Ile Asp Ala Asn Thr Asp Asn Leu Pro 
705                 710                 715                 720 


Lys Ala His Thr Cys Phe Asn Arg Ile Asp Ile Pro Pro Tyr Glu Ser 
                725                 730                 735     


Tyr Glu Lys Leu Tyr Glu Lys Leu Leu Thr Ala Val Glu Glu Thr Cys 
            740                 745                 750         


Gly Phe Ala Val Glu 
        755         


<210>  11
<211>  748
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Asn Pro Gly Gly Arg Arg Asn Gly Pro Val Lys Leu Arg Leu 
1               5                   10                  15      


Thr Val Leu Cys Ala Lys Asn Leu Val Lys Lys Asp Phe Phe Arg Leu 
            20                  25                  30          


Pro Asp Pro Phe Ala Lys Val Val Val Asp Gly Ser Gly Gln Cys His 
        35                  40                  45              


Ser Thr Asp Thr Val Lys Asn Thr Leu Asp Pro Lys Trp Asn Gln His 
    50                  55                  60                  


Tyr Asp Leu Tyr Ile Gly Lys Ser Asp Ser Val Thr Ile Ser Val Trp 
65                  70                  75                  80  


Asn His Lys Lys Ile His Lys Lys Gln Gly Ala Gly Phe Leu Gly Cys 
                85                  90                  95      


Val Arg Leu Leu Ser Asn Ala Ile Asn Arg Leu Lys Asp Thr Gly Tyr 
            100                 105                 110         


Gln Arg Leu Asp Leu Cys Lys Leu Gly Pro Asn Asp Asn Asp Thr Val 
        115                 120                 125             


Arg Gly Gln Ile Val Val Ser Leu Gln Ser Arg Asp Arg Ile Gly Thr 
    130                 135                 140                 


Gly Gly Gln Val Val Asp Cys Ser Arg Leu Phe Asp Asn Asp Leu Pro 
145                 150                 155                 160 


Asp Gly Trp Glu Glu Arg Arg Thr Ala Ser Gly Arg Ile Gln Tyr Leu 
                165                 170                 175     


Asn His Ile Thr Arg Thr Thr Gln Trp Glu Arg Pro Thr Arg Pro Ala 
            180                 185                 190         


Ser Glu Tyr Ser Ser Pro Gly Arg Pro Leu Ser Cys Phe Val Asp Glu 
        195                 200                 205             


Asn Thr Pro Ile Ser Gly Thr Asn Gly Ala Thr Cys Gly Gln Ser Ser 
    210                 215                 220                 


Asp Pro Arg Leu Ala Glu Arg Arg Val Arg Ser Gln Arg His Arg Asn 
225                 230                 235                 240 


Tyr Met Ser Arg Thr His Leu His Thr Pro Pro Asp Leu Pro Glu Gly 
                245                 250                 255     


Tyr Glu Gln Arg Thr Thr Gln Gln Gly Gln Val Tyr Phe Leu His Thr 
            260                 265                 270         


Gln Thr Gly Val Ser Thr Trp His Asp Pro Arg Val Pro Arg Asp Leu 
        275                 280                 285             


Ser Asn Ile Asn Cys Glu Glu Leu Gly Pro Leu Pro Pro Gly Trp Glu 
    290                 295                 300                 


Ile Arg Asn Thr Ala Thr Gly Arg Val Tyr Phe Val Asp His Asn Asn 
305                 310                 315                 320 


Arg Thr Thr Gln Phe Thr Asp Pro Arg Leu Ser Ala Asn Leu His Leu 
                325                 330                 335     


Val Leu Asn Arg Gln Asn Gln Leu Lys Asp Gln Gln Gln Gln Gln Val 
            340                 345                 350         


Val Ser Leu Cys Pro Asp Asp Thr Glu Cys Leu Thr Val Pro Arg Tyr 
        355                 360                 365             


Lys Arg Asp Leu Val Gln Lys Leu Lys Ile Leu Arg Gln Glu Leu Ser 
    370                 375                 380                 


Gln Gln Gln Pro Gln Ala Gly His Cys Arg Ile Glu Val Ser Arg Glu 
385                 390                 395                 400 


Glu Ile Phe Glu Glu Ser Tyr Arg Gln Val Met Lys Met Arg Pro Lys 
                405                 410                 415     


Asp Leu Trp Lys Arg Leu Met Ile Lys Phe Arg Gly Glu Glu Gly Leu 
            420                 425                 430         


Asp Tyr Gly Gly Val Ala Arg Glu Trp Leu Tyr Leu Leu Ser His Glu 
        435                 440                 445             


Met Leu Asn Pro Tyr Tyr Gly Leu Phe Gln Tyr Ser Arg Asp Asp Ile 
    450                 455                 460                 


Tyr Thr Leu Gln Ile Asn Pro Asp Ser Ala Val Asn Pro Glu His Leu 
465                 470                 475                 480 


Ser Tyr Phe His Phe Val Gly Arg Ile Met Gly Met Ala Val Phe His 
                485                 490                 495     


Gly His Tyr Ile Asp Gly Gly Phe Thr Leu Pro Phe Tyr Lys Gln Leu 
            500                 505                 510         


Leu Gly Lys Ser Ile Thr Leu Asp Asp Met Glu Leu Val Asp Pro Asp 
        515                 520                 525             


Leu His Asn Ser Leu Val Trp Ile Leu Glu Asn Asp Ile Thr Gly Val 
    530                 535                 540                 


Leu Asp His Thr Phe Cys Val Glu His Asn Ala Tyr Gly Glu Ile Ile 
545                 550                 555                 560 


Gln His Glu Leu Lys Pro Asn Gly Lys Ser Ile Pro Val Asn Glu Glu 
                565                 570                 575     


Asn Lys Lys Glu Tyr Val Arg Leu Tyr Val Asn Trp Arg Phe Leu Arg 
            580                 585                 590         


Gly Ile Glu Ala Gln Phe Leu Ala Leu Gln Lys Gly Phe Asn Glu Val 
        595                 600                 605             


Ile Pro Gln His Leu Leu Lys Thr Phe Asp Glu Lys Glu Leu Glu Leu 
    610                 615                 620                 


Ile Ile Cys Gly Leu Gly Lys Ile Asp Val Asn Asp Trp Lys Val Asn 
625                 630                 635                 640 


Thr Arg Leu Lys His Cys Thr Pro Asp Ser Asn Ile Val Lys Trp Phe 
                645                 650                 655     


Trp Lys Ala Val Glu Phe Phe Asp Glu Glu Arg Arg Ala Arg Leu Leu 
            660                 665                 670         


Gln Phe Val Thr Gly Ser Ser Arg Val Pro Leu Gln Gly Phe Lys Ala 
        675                 680                 685             


Leu Gln Gly Ala Ala Gly Pro Arg Leu Phe Thr Ile His Gln Ile Asp 
    690                 695                 700                 


Ala Cys Thr Asn Asn Leu Pro Lys Ala His Thr Cys Phe Asn Arg Ile 
705                 710                 715                 720 


Asp Ile Pro Pro Tyr Glu Ser Tyr Glu Lys Leu Tyr Glu Lys Leu Leu 
                725                 730                 735     


Thr Ala Ile Glu Glu Thr Cys Gly Phe Ala Val Glu 
            740                 745             


<210>  12
<211>  903
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Asp Ser Gly Ser Gln Leu Gly Ser Met Gly Ser Leu Thr Met 
1               5                   10                  15      


Lys Ser Gln Leu Gln Ile Thr Val Ile Ser Ala Lys Leu Lys Glu Asn 
            20                  25                  30          


Lys Lys Asn Trp Phe Gly Pro Ser Pro Tyr Val Glu Val Thr Val Asp 
        35                  40                  45              


Gly Gln Ser Lys Lys Thr Glu Lys Cys Asn Asn Thr Asn Ser Pro Lys 
    50                  55                  60                  


Trp Lys Gln Pro Leu Thr Val Ile Val Thr Pro Val Ser Lys Leu His 
65                  70                  75                  80  


Phe Arg Val Trp Ser His Gln Thr Leu Lys Ser Asp Val Leu Leu Gly 
                85                  90                  95      


Thr Ala Ala Leu Asp Ile Tyr Glu Thr Leu Lys Ser Asn Asn Met Lys 
            100                 105                 110         


Leu Glu Glu Val Val Val Thr Leu Gln Leu Gly Gly Asp Lys Glu Pro 
        115                 120                 125             


Thr Glu Thr Ile Gly Asp Leu Ser Ile Cys Leu Asp Gly Leu Gln Leu 
    130                 135                 140                 


Glu Ser Glu Val Val Thr Asn Gly Glu Thr Thr Cys Ser Glu Asn Gly 
145                 150                 155                 160 


Val Ser Leu Cys Leu Pro Arg Leu Glu Cys Asn Ser Ala Ile Ser Ala 
                165                 170                 175     


His Cys Asn Leu Cys Leu Pro Gly Leu Ser Asp Ser Pro Ile Ser Ala 
            180                 185                 190         


Ser Arg Val Ala Gly Phe Thr Gly Ala Ser Gln Asn Asp Asp Gly Ser 
        195                 200                 205             


Arg Ser Lys Asp Glu Thr Arg Val Ser Thr Asn Gly Ser Asp Asp Pro 
    210                 215                 220                 


Glu Asp Ala Gly Ala Gly Glu Asn Arg Arg Val Ser Gly Asn Asn Ser 
225                 230                 235                 240 


Pro Ser Leu Ser Asn Gly Gly Phe Lys Pro Ser Arg Pro Pro Arg Pro 
                245                 250                 255     


Ser Arg Pro Pro Pro Pro Thr Pro Arg Arg Pro Ala Ser Val Asn Gly 
            260                 265                 270         


Ser Pro Ser Ala Thr Ser Glu Ser Asp Gly Ser Ser Thr Gly Ser Leu 
        275                 280                 285             


Pro Pro Thr Asn Thr Asn Thr Asn Thr Ser Glu Gly Ala Thr Ser Gly 
    290                 295                 300                 


Leu Ile Ile Pro Leu Thr Ile Ser Gly Gly Ser Gly Pro Arg Pro Leu 
305                 310                 315                 320 


Asn Pro Val Thr Gln Ala Pro Leu Pro Pro Gly Trp Glu Gln Arg Val 
                325                 330                 335     


Asp Gln His Gly Arg Val Tyr Tyr Val Asp His Val Glu Lys Arg Thr 
            340                 345                 350         


Thr Trp Asp Arg Pro Glu Pro Leu Pro Pro Gly Trp Glu Arg Arg Val 
        355                 360                 365             


Asp Asn Met Gly Arg Ile Tyr Tyr Val Asp His Phe Thr Arg Thr Thr 
    370                 375                 380                 


Thr Trp Gln Arg Pro Thr Leu Glu Ser Val Arg Asn Tyr Glu Gln Trp 
385                 390                 395                 400 


Gln Leu Gln Arg Ser Gln Leu Gln Gly Ala Met Gln Gln Phe Asn Gln 
                405                 410                 415     


Arg Phe Ile Tyr Gly Asn Gln Asp Leu Phe Ala Thr Ser Gln Ser Lys 
            420                 425                 430         


Glu Phe Asp Pro Leu Gly Pro Leu Pro Pro Gly Trp Glu Lys Arg Thr 
        435                 440                 445             


Asp Ser Asn Gly Arg Val Tyr Phe Val Asn His Asn Thr Arg Ile Thr 
    450                 455                 460                 


Gln Trp Glu Asp Pro Arg Ser Gln Gly Gln Leu Asn Glu Lys Pro Leu 
465                 470                 475                 480 


Pro Glu Gly Trp Glu Met Arg Phe Thr Val Asp Gly Ile Pro Tyr Phe 
                485                 490                 495     


Val Asp His Asn Arg Arg Thr Thr Thr Tyr Ile Asp Pro Arg Thr Gly 
            500                 505                 510         


Lys Ser Ala Leu Asp Asn Gly Pro Gln Ile Ala Tyr Val Arg Asp Phe 
        515                 520                 525             


Lys Ala Lys Val Gln Tyr Phe Arg Phe Trp Cys Gln Gln Leu Ala Met 
    530                 535                 540                 


Pro Gln His Ile Lys Ile Thr Val Thr Arg Lys Thr Leu Phe Glu Asp 
545                 550                 555                 560 


Ser Phe Gln Gln Ile Met Ser Phe Ser Pro Gln Asp Leu Arg Arg Arg 
                565                 570                 575     


Leu Trp Val Ile Phe Pro Gly Glu Glu Gly Leu Asp Tyr Gly Gly Val 
            580                 585                 590         


Ala Arg Glu Trp Phe Phe Leu Leu Ser His Glu Val Leu Asn Pro Met 
        595                 600                 605             


Tyr Cys Leu Phe Glu Tyr Ala Gly Lys Asp Asn Tyr Cys Leu Gln Ile 
    610                 615                 620                 


Asn Pro Ala Ser Tyr Ile Asn Pro Asp His Leu Lys Tyr Phe Arg Phe 
625                 630                 635                 640 


Ile Gly Arg Phe Ile Ala Met Ala Leu Phe His Gly Lys Phe Ile Asp 
                645                 650                 655     


Thr Gly Phe Ser Leu Pro Phe Tyr Lys Arg Ile Leu Asn Lys Pro Val 
            660                 665                 670         


Gly Leu Lys Asp Leu Glu Ser Ile Asp Pro Glu Phe Tyr Asn Ser Leu 
        675                 680                 685             


Ile Trp Val Lys Glu Asn Asn Ile Glu Glu Cys Asp Leu Glu Met Tyr 
    690                 695                 700                 


Phe Ser Val Asp Lys Glu Ile Leu Gly Glu Ile Lys Ser His Asp Leu 
705                 710                 715                 720 


Lys Pro Asn Gly Gly Asn Ile Leu Val Thr Glu Glu Asn Lys Glu Glu 
                725                 730                 735     


Tyr Ile Arg Met Val Ala Glu Trp Arg Leu Ser Arg Gly Val Glu Glu 
            740                 745                 750         


Gln Thr Gln Ala Phe Phe Glu Gly Phe Asn Glu Ile Leu Pro Gln Gln 
        755                 760                 765             


Tyr Leu Gln Tyr Phe Asp Ala Lys Glu Leu Glu Val Leu Leu Cys Gly 
    770                 775                 780                 


Met Gln Glu Ile Asp Leu Asn Asp Trp Gln Arg His Ala Ile Tyr Arg 
785                 790                 795                 800 


His Tyr Ala Arg Thr Ser Lys Gln Ile Met Trp Phe Trp Gln Phe Val 
                805                 810                 815     


Lys Glu Ile Asp Asn Glu Lys Arg Met Arg Leu Leu Gln Phe Val Thr 
            820                 825                 830         


Gly Thr Cys Arg Leu Pro Val Gly Gly Phe Ala Asp Leu Met Gly Ser 
        835                 840                 845             


Asn Gly Pro Gln Lys Phe Cys Ile Glu Lys Val Gly Lys Glu Asn Trp 
    850                 855                 860                 


Leu Pro Arg Ser His Thr Cys Phe Asn Arg Leu Asp Leu Pro Pro Tyr 
865                 870                 875                 880 


Lys Ser Tyr Glu Gln Leu Lys Glu Lys Leu Leu Phe Ala Ile Glu Glu 
                885                 890                 895     


Thr Glu Gly Phe Gly Gln Glu 
            900             


<210>  13
<211>  1606
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Leu Leu His Leu Cys Ser Val Lys Asn Leu Tyr Gln Asn Arg Phe 
1               5                   10                  15      


Leu Gly Leu Ala Ala Met Ala Ser Pro Ser Arg Asn Ser Gln Ser Arg 
            20                  25                  30          


Arg Arg Cys Lys Glu Pro Leu Arg Tyr Ser Tyr Asn Pro Asp Gln Phe 
        35                  40                  45              


His Asn Met Asp Leu Arg Gly Gly Pro His Asp Gly Val Thr Ile Pro 
    50                  55                  60                  


Arg Ser Thr Ser Asp Thr Asp Leu Val Thr Ser Asp Ser Arg Ser Thr 
65                  70                  75                  80  


Leu Met Val Ser Ser Ser Tyr Tyr Ser Ile Gly His Ser Gln Asp Leu 
                85                  90                  95      


Val Ile His Trp Asp Ile Lys Glu Glu Val Asp Ala Gly Asp Trp Ile 
            100                 105                 110         


Gly Met Tyr Leu Ile Asp Glu Val Leu Ser Glu Asn Phe Leu Asp Tyr 
        115                 120                 125             


Lys Asn Arg Gly Val Asn Gly Ser His Arg Gly Gln Ile Ile Trp Lys 
    130                 135                 140                 


Ile Asp Ala Ser Ser Tyr Phe Val Glu Pro Glu Thr Lys Ile Cys Phe 
145                 150                 155                 160 


Lys Tyr Tyr His Gly Val Ser Gly Ala Leu Arg Ala Thr Thr Pro Ser 
                165                 170                 175     


Val Thr Val Lys Asn Ser Ala Ala Pro Ile Phe Lys Ser Ile Gly Ala 
            180                 185                 190         


Asp Glu Thr Val Gln Gly Gln Gly Ser Arg Arg Leu Ile Ser Phe Ser 
        195                 200                 205             


Leu Ser Asp Phe Gln Ala Met Gly Leu Lys Lys Gly Met Phe Phe Asn 
    210                 215                 220                 


Pro Asp Pro Tyr Leu Lys Ile Ser Ile Gln Pro Gly Lys His Ser Ile 
225                 230                 235                 240 


Phe Pro Ala Leu Pro His His Gly Gln Glu Arg Arg Ser Lys Ile Ile 
                245                 250                 255     


Gly Asn Thr Val Asn Pro Ile Trp Gln Ala Glu Gln Phe Ser Phe Val 
            260                 265                 270         


Ser Leu Pro Thr Asp Val Leu Glu Ile Glu Val Lys Asp Lys Phe Ala 
        275                 280                 285             


Lys Ser Arg Pro Ile Ile Lys Arg Phe Leu Gly Lys Leu Ser Met Pro 
    290                 295                 300                 


Val Gln Arg Leu Leu Glu Arg His Ala Ile Gly Asp Arg Val Val Ser 
305                 310                 315                 320 


Tyr Thr Leu Gly Arg Arg Leu Pro Thr Asp His Val Ser Gly Gln Leu 
                325                 330                 335     


Gln Phe Arg Phe Glu Ile Thr Ser Ser Ile His Pro Asp Asp Glu Glu 
            340                 345                 350         


Ile Ser Leu Ser Thr Glu Pro Glu Ser Ala Gln Ile Gln Asp Ser Pro 
        355                 360                 365             


Met Asn Asn Leu Met Glu Ser Gly Ser Gly Glu Pro Arg Ser Glu Ala 
    370                 375                 380                 


Pro Glu Ser Ser Glu Ser Trp Lys Pro Glu Gln Leu Gly Glu Gly Ser 
385                 390                 395                 400 


Val Pro Asp Gly Pro Gly Asn Gln Ser Ile Glu Leu Ser Arg Pro Ala 
                405                 410                 415     


Glu Glu Ala Ala Val Ile Thr Glu Ala Gly Asp Gln Gly Met Val Ser 
            420                 425                 430         


Val Gly Pro Glu Gly Ala Gly Glu Leu Leu Ala Gln Val Gln Lys Asp 
        435                 440                 445             


Ile Gln Pro Ala Pro Ser Ala Glu Glu Leu Ala Glu Gln Leu Asp Leu 
    450                 455                 460                 


Gly Glu Glu Ala Ser Ala Leu Leu Leu Glu Asp Gly Glu Ala Pro Ala 
465                 470                 475                 480 


Ser Thr Lys Glu Glu Pro Leu Glu Glu Glu Ala Thr Thr Gln Ser Arg 
                485                 490                 495     


Ala Gly Arg Glu Glu Glu Glu Lys Glu Gln Glu Glu Glu Gly Asp Val 
            500                 505                 510         


Ser Thr Leu Glu Gln Gly Glu Gly Arg Leu Gln Leu Arg Ala Ser Val 
        515                 520                 525             


Lys Arg Lys Ser Arg Pro Cys Ser Leu Pro Val Ser Glu Leu Glu Thr 
    530                 535                 540                 


Val Ile Ala Ser Ala Cys Gly Asp Pro Glu Thr Pro Arg Thr His Tyr 
545                 550                 555                 560 


Ile Arg Ile His Thr Leu Leu His Ser Met Pro Ser Ala Gln Gly Gly 
                565                 570                 575     


Ser Ala Ala Glu Glu Glu Asp Gly Ala Glu Glu Glu Ser Thr Leu Lys 
            580                 585                 590         


Asp Ser Ser Glu Lys Asp Gly Leu Ser Glu Val Asp Thr Val Ala Ala 
        595                 600                 605             


Asp Pro Ser Ala Leu Glu Glu Asp Arg Glu Glu Pro Glu Gly Ala Thr 
    610                 615                 620                 


Pro Gly Thr Ala His Pro Gly His Ser Gly Gly His Phe Pro Ser Leu 
625                 630                 635                 640 


Ala Asn Gly Ala Ala Gln Asp Gly Asp Thr His Pro Ser Thr Gly Ser 
                645                 650                 655     


Glu Ser Asp Ser Ser Pro Arg Gln Gly Gly Asp His Ser Cys Glu Gly 
            660                 665                 670         


Cys Asp Ala Ser Cys Cys Ser Pro Ser Cys Tyr Ser Ser Ser Cys Tyr 
        675                 680                 685             


Ser Thr Ser Cys Tyr Ser Ser Ser Cys Tyr Ser Ala Ser Cys Tyr Ser 
    690                 695                 700                 


Pro Ser Cys Tyr Asn Gly Asn Arg Phe Ala Ser His Thr Arg Phe Ser 
705                 710                 715                 720 


Ser Val Asp Ser Ala Lys Ile Ser Glu Ser Thr Val Phe Ser Ser Gln 
                725                 730                 735     


Asp Asp Glu Glu Glu Glu Asn Ser Ala Phe Glu Ser Val Pro Asp Ser 
            740                 745                 750         


Met Gln Ser Pro Glu Leu Asp Pro Glu Ser Thr Asn Gly Ala Gly Pro 
        755                 760                 765             


Trp Gln Asp Glu Leu Ala Ala Pro Ser Gly His Val Glu Arg Ser Pro 
    770                 775                 780                 


Glu Gly Leu Glu Ser Pro Val Ala Gly Pro Ser Asn Arg Arg Glu Gly 
785                 790                 795                 800 


Glu Cys Pro Ile Leu His Asn Ser Gln Pro Val Ser Gln Leu Pro Ser 
                805                 810                 815     


Leu Arg Pro Glu His His His Tyr Pro Thr Ile Asp Glu Pro Leu Pro 
            820                 825                 830         


Pro Asn Trp Glu Ala Arg Ile Asp Ser His Gly Arg Val Phe Tyr Val 
        835                 840                 845             


Asp His Val Asn Arg Thr Thr Thr Trp Gln Arg Pro Thr Ala Ala Ala 
    850                 855                 860                 


Thr Pro Asp Gly Met Arg Arg Ser Gly Ser Ile Gln Gln Met Glu Gln 
865                 870                 875                 880 


Leu Asn Arg Arg Tyr Gln Asn Ile Gln Arg Thr Ile Ala Thr Glu Arg 
                885                 890                 895     


Ser Glu Glu Asp Ser Gly Ser Gln Ser Cys Glu Gln Ala Pro Ala Gly 
            900                 905                 910         


Gly Gly Gly Gly Gly Gly Ser Asp Ser Glu Ala Glu Ser Ser Gln Ser 
        915                 920                 925             


Ser Leu Asp Leu Arg Arg Glu Gly Ser Leu Ser Pro Val Asn Ser Gln 
    930                 935                 940                 


Lys Ile Thr Leu Leu Leu Gln Ser Pro Ala Val Lys Phe Ile Thr Asn 
945                 950                 955                 960 


Pro Glu Phe Phe Thr Val Leu His Ala Asn Tyr Ser Ala Tyr Arg Val 
                965                 970                 975     


Phe Thr Ser Ser Thr Cys Leu Lys His Met Ile Leu Lys Val Arg Arg 
            980                 985                 990         


Asp Ala Arg Asn Phe Glu Arg Tyr  Gln His Asn Arg Asp  Leu Val Asn 
        995                 1000                 1005             


Phe Ile  Asn Met Phe Ala Asp  Thr Arg Leu Glu Leu  Pro Arg Gly 
    1010                 1015                 1020             


Trp Glu  Ile Lys Thr Asp Gln  Gln Gly Lys Ser Phe  Phe Val Asp 
    1025                 1030                 1035             


His Asn  Ser Arg Ala Thr Thr  Phe Ile Asp Pro Arg  Ile Pro Leu 
    1040                 1045                 1050             


Gln Asn  Gly Arg Leu Pro Asn  His Leu Thr His Arg  Gln His Leu 
    1055                 1060                 1065             


Gln Arg  Leu Arg Ser Tyr Ser  Ala Gly Glu Ala Ser  Glu Val Ser 
    1070                 1075                 1080             


Arg Asn  Arg Gly Ala Ser Leu  Leu Ala Arg Pro Gly  His Ser Leu 
    1085                 1090                 1095             


Val Ala  Ala Ile Arg Ser Gln  His Gln His Glu Ser  Leu Pro Leu 
    1100                 1105                 1110             


Ala Tyr  Asn Asp Lys Ile Val  Ala Phe Leu Arg Gln  Pro Asn Ile 
    1115                 1120                 1125             


Phe Glu  Met Leu Gln Glu Arg  Gln Pro Ser Leu Ala  Arg Asn His 
    1130                 1135                 1140             


Thr Leu  Arg Glu Lys Ile His  Tyr Ile Arg Thr Glu  Gly Asn His 
    1145                 1150                 1155             


Gly Leu  Glu Lys Leu Ser Cys  Asp Ala Asp Leu Val  Ile Leu Leu 
    1160                 1165                 1170             


Ser Leu  Phe Glu Glu Glu Ile  Met Ser Tyr Val Pro  Leu Gln Ala 
    1175                 1180                 1185             


Ala Phe  His Pro Gly Tyr Ser  Phe Ser Pro Arg Cys  Ser Pro Cys 
    1190                 1195                 1200             


Ser Ser  Pro Gln Asn Ser Pro  Gly Leu Gln Arg Ala  Ser Ala Arg 
    1205                 1210                 1215             


Ala Pro  Ser Pro Tyr Arg Arg  Asp Phe Glu Ala Lys  Leu Arg Asn 
    1220                 1225                 1230             


Phe Tyr  Arg Lys Leu Glu Ala  Lys Gly Phe Gly Gln  Gly Pro Gly 
    1235                 1240                 1245             


Lys Ile  Lys Leu Ile Ile Arg  Arg Asp His Leu Leu  Glu Gly Thr 
    1250                 1255                 1260             


Phe Asn  Gln Val Met Ala Tyr  Ser Arg Lys Glu Leu  Gln Arg Asn 
    1265                 1270                 1275             


Lys Leu  Tyr Val Thr Phe Val  Gly Glu Glu Gly Leu  Asp Tyr Ser 
    1280                 1285                 1290             


Gly Pro  Ser Arg Glu Phe Phe  Phe Leu Leu Ser Gln  Glu Leu Phe 
    1295                 1300                 1305             


Asn Pro  Tyr Tyr Gly Leu Phe  Glu Tyr Ser Ala Asn  Asp Thr Tyr 
    1310                 1315                 1320             


Thr Val  Gln Ile Ser Pro Met  Ser Ala Phe Val Glu  Asn His Leu 
    1325                 1330                 1335             


Glu Trp  Phe Arg Phe Ser Gly  Arg Ile Leu Gly Leu  Ala Leu Ile 
    1340                 1345                 1350             


His Gln  Tyr Leu Leu Asp Ala  Phe Phe Thr Arg Pro  Phe Tyr Lys 
    1355                 1360                 1365             


Ala Leu  Leu Arg Leu Pro Cys  Asp Leu Ser Asp Leu  Glu Tyr Leu 
    1370                 1375                 1380             


Asp Glu  Glu Phe His Gln Ser  Leu Gln Trp Met Lys  Asp Asn Asn 
    1385                 1390                 1395             


Ile Thr  Asp Ile Leu Asp Leu  Thr Phe Thr Val Asn  Glu Glu Val 
    1400                 1405                 1410             


Phe Gly  Gln Val Thr Glu Arg  Glu Leu Lys Ser Gly  Gly Ala Asn 
    1415                 1420                 1425             


Thr Gln  Val Thr Glu Lys Asn  Lys Lys Glu Tyr Ile  Glu Arg Met 
    1430                 1435                 1440             


Val Lys  Trp Arg Val Glu Arg  Gly Val Val Gln Gln  Thr Glu Ala 
    1445                 1450                 1455             


Leu Val  Arg Gly Phe Tyr Glu  Val Val Asp Ser Arg  Leu Val Ser 
    1460                 1465                 1470             


Val Phe  Asp Ala Arg Glu Leu  Glu Leu Val Ile Ala  Gly Thr Ala 
    1475                 1480                 1485             


Glu Ile  Asp Leu Asn Asp Trp  Arg Asn Asn Thr Glu  Tyr Arg Gly 
    1490                 1495                 1500             


Gly Tyr  His Asp Gly His Leu  Val Ile Arg Trp Phe  Trp Ala Ala 
    1505                 1510                 1515             


Val Glu  Arg Phe Asn Asn Glu  Gln Arg Leu Arg Leu  Leu Gln Phe 
    1520                 1525                 1530             


Val Thr  Gly Thr Ser Ser Val  Pro Tyr Glu Gly Phe  Ala Ala Leu 
    1535                 1540                 1545             


Arg Gly  Ser Asn Gly Leu Arg  Arg Phe Cys Ile Glu  Lys Trp Gly 
    1550                 1555                 1560             


Lys Ile  Thr Ser Leu Pro Arg  Ala His Thr Cys Phe  Asn Arg Leu 
    1565                 1570                 1575             


Asp Leu  Pro Pro Tyr Pro Ser  Tyr Ser Met Leu Tyr  Glu Lys Leu 
    1580                 1585                 1590             


Leu Thr  Ala Val Glu Glu Thr  Ser Thr Phe Gly Leu  Glu 
    1595                 1600                 1605     


<210>  14
<211>  1572
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Ser Ser Ala Arg Glu His Leu Leu Phe Val Arg Arg Arg Asn 
1               5                   10                  15      


Pro Gln Met Arg Tyr Thr Leu Ser Pro Glu Asn Leu Gln Ser Leu Ala 
            20                  25                  30          


Ala Gln Ser Ser Met Pro Glu Asn Met Thr Leu Gln Arg Ala Asn Ser 
        35                  40                  45              


Asp Thr Asp Leu Val Thr Ser Glu Ser Arg Ser Ser Leu Thr Ala Ser 
    50                  55                  60                  


Met Tyr Glu Tyr Thr Leu Gly Gln Ala Gln Asn Leu Ile Ile Phe Trp 
65                  70                  75                  80  


Asp Ile Lys Glu Glu Val Asp Pro Ser Asp Trp Ile Gly Leu Tyr His 
                85                  90                  95      


Ile Asp Glu Asn Ser Pro Ala Asn Phe Trp Asp Ser Lys Asn Arg Gly 
            100                 105                 110         


Val Thr Gly Thr Gln Lys Gly Gln Ile Val Trp Arg Ile Glu Pro Gly 
        115                 120                 125             


Pro Tyr Phe Met Glu Pro Glu Ile Lys Ile Cys Phe Lys Tyr Tyr His 
    130                 135                 140                 


Gly Ile Ser Gly Ala Leu Arg Ala Thr Thr Pro Cys Ile Thr Val Lys 
145                 150                 155                 160 


Asn Pro Ala Val Met Met Gly Ala Glu Gly Met Glu Gly Gly Ala Ser 
                165                 170                 175     


Gly Asn Leu His Ser Arg Lys Leu Val Ser Phe Thr Leu Ser Asp Leu 
            180                 185                 190         


Arg Ala Val Gly Leu Lys Lys Gly Met Phe Phe Asn Pro Asp Pro Tyr 
        195                 200                 205             


Leu Lys Met Ser Ile Gln Pro Gly Lys Lys Ser Ser Phe Pro Thr Cys 
    210                 215                 220                 


Ala His His Gly Gln Glu Arg Arg Ser Thr Ile Ile Ser Asn Thr Thr 
225                 230                 235                 240 


Asn Pro Ile Trp His Arg Glu Lys Tyr Ser Phe Phe Ala Leu Leu Thr 
                245                 250                 255     


Asp Val Leu Glu Ile Glu Ile Lys Asp Lys Phe Ala Lys Ser Arg Pro 
            260                 265                 270         


Ile Ile Lys Arg Phe Leu Gly Lys Leu Thr Ile Pro Val Gln Arg Leu 
        275                 280                 285             


Leu Glu Arg Gln Ala Ile Gly Asp Gln Met Leu Ser Tyr Asn Leu Gly 
    290                 295                 300                 


Arg Arg Leu Pro Ala Asp His Val Ser Gly Tyr Leu Gln Phe Lys Val 
305                 310                 315                 320 


Glu Val Thr Ser Ser Val His Glu Asp Ala Ser Pro Glu Ala Val Gly 
                325                 330                 335     


Thr Ile Leu Gly Val Asn Ser Val Asn Gly Asp Leu Gly Ser Pro Ser 
            340                 345                 350         


Asp Asp Glu Asp Met Pro Gly Ser His His Asp Ser Gln Val Cys Ser 
        355                 360                 365             


Asn Gly Pro Val Ser Glu Asp Ser Ala Ala Asp Gly Thr Pro Lys His 
    370                 375                 380                 


Ser Phe Arg Thr Ser Ser Thr Leu Glu Ile Asp Thr Glu Glu Leu Thr 
385                 390                 395                 400 


Ser Thr Ser Ser Arg Thr Ser Pro Pro Arg Gly Arg Gln Asp Ser Leu 
                405                 410                 415     


Asn Asp Tyr Leu Asp Ala Ile Glu His Asn Gly His Ser Arg Pro Gly 
            420                 425                 430         


Thr Ala Thr Cys Ser Glu Arg Ser Met Gly Ala Ser Pro Lys Leu Arg 
        435                 440                 445             


Ser Ser Phe Pro Thr Asp Thr Arg Leu Asn Ala Met Leu His Ile Asp 
    450                 455                 460                 


Ser Asp Glu Glu Asp His Glu Phe Gln Gln Asp Leu Gly Tyr Pro Ser 
465                 470                 475                 480 


Ser Leu Glu Glu Glu Gly Gly Leu Ile Met Phe Ser Arg Ala Ser Arg 
                485                 490                 495     


Ala Asp Asp Gly Ser Leu Thr Ser Gln Thr Lys Leu Glu Asp Asn Pro 
            500                 505                 510         


Val Glu Asn Glu Glu Ala Ser Thr His Glu Ala Ala Ser Phe Glu Asp 
        515                 520                 525             


Lys Pro Glu Asn Leu Pro Glu Leu Ala Glu Ser Ser Leu Pro Ala Gly 
    530                 535                 540                 


Pro Ala Pro Glu Glu Gly Glu Gly Gly Pro Glu Pro Gln Pro Ser Ala 
545                 550                 555                 560 


Asp Gln Gly Ser Ala Glu Leu Cys Gly Ser Gln Glu Val Asp Gln Pro 
                565                 570                 575     


Thr Ser Gly Ala Asp Thr Gly Thr Ser Asp Ala Ser Gly Gly Ser Arg 
            580                 585                 590         


Arg Ala Val Ser Glu Thr Glu Ser Leu Asp Gln Gly Ser Glu Pro Ser 
        595                 600                 605             


Gln Val Ser Ser Glu Thr Glu Pro Ser Asp Pro Ala Arg Thr Glu Ser 
    610                 615                 620                 


Val Ser Glu Ala Ser Thr Arg Pro Glu Gly Glu Ser Asp Leu Glu Cys 
625                 630                 635                 640 


Ala Asp Ser Ser Cys Asn Glu Ser Val Thr Thr Gln Leu Ser Ser Val 
                645                 650                 655     


Asp Thr Arg Cys Ser Ser Leu Glu Ser Ala Arg Phe Pro Glu Thr Pro 
            660                 665                 670         


Ala Phe Ser Ser Gln Glu Glu Glu Asp Gly Ala Cys Ala Ala Glu Pro 
        675                 680                 685             


Thr Ser Ser Gly Pro Ala Glu Gly Ser Gln Glu Ser Val Cys Thr Ala 
    690                 695                 700                 


Gly Ser Leu Pro Val Val Gln Val Pro Ser Gly Glu Asp Glu Gly Pro 
705                 710                 715                 720 


Gly Ala Glu Ser Ala Thr Val Pro Asp Gln Glu Glu Leu Gly Glu Val 
                725                 730                 735     


Trp Gln Arg Arg Gly Ser Leu Glu Gly Ala Ala Ala Ala Ala Glu Ser 
            740                 745                 750         


Pro Pro Gln Glu Glu Gly Ser Ala Gly Glu Ala Gln Gly Thr Cys Glu 
        755                 760                 765             


Gly Ala Thr Ala Gln Glu Glu Gly Ala Thr Gly Gly Ser Gln Ala Asn 
    770                 775                 780                 


Gly His Gln Pro Leu Arg Ser Leu Pro Ser Val Arg Gln Asp Val Ser 
785                 790                 795                 800 


Arg Tyr Gln Arg Val Asp Glu Ala Leu Pro Pro Asn Trp Glu Ala Arg 
                805                 810                 815     


Ile Asp Ser His Gly Arg Ile Phe Tyr Val Asp His Val Asn Arg Thr 
            820                 825                 830         


Thr Thr Trp Gln Arg Pro Thr Ala Pro Pro Ala Pro Gln Val Leu Gln 
        835                 840                 845             


Arg Ser Asn Ser Ile Gln Gln Met Glu Gln Leu Asn Arg Arg Tyr Gln 
    850                 855                 860                 


Ser Ile Arg Arg Thr Met Thr Asn Glu Arg Pro Glu Glu Asn Thr Asn 
865                 870                 875                 880 


Ala Ile Asp Gly Ala Gly Glu Glu Ala Asp Phe His Gln Ala Ser Ala 
                885                 890                 895     


Asp Phe Arg Arg Glu Asn Ile Leu Pro His Ser Thr Ser Arg Ser Arg 
            900                 905                 910         


Ile Thr Leu Leu Leu Gln Ser Pro Pro Val Lys Phe Leu Ile Ser Pro 
        915                 920                 925             


Glu Phe Phe Thr Val Leu His Ser Asn Pro Ser Ala Tyr Arg Met Phe 
    930                 935                 940                 


Thr Asn Asn Thr Cys Leu Lys His Met Ile Thr Lys Val Arg Arg Asp 
945                 950                 955                 960 


Thr His His Phe Glu Arg Tyr Gln His Asn Arg Asp Leu Val Gly Phe 
                965                 970                 975     


Leu Asn Met Phe Ala Asn Lys Gln Leu Glu Leu Pro Arg Gly Trp Glu 
            980                 985                 990         


Met Lys His Asp His Gln Gly Lys  Ala Phe Phe Val Asp  His Asn Ser 
        995                 1000                 1005             


Arg Thr  Thr Thr Phe Ile Asp  Pro Arg Leu Pro Leu  Gln Ser Ser 
    1010                 1015                 1020             


Arg Pro  Thr Ser Ala Leu Val  His Arg Gln His Leu  Thr Arg Gln 
    1025                 1030                 1035             


Arg Ser  His Ser Ala Gly Glu  Val Gly Glu Asp Ser  Arg His Ala 
    1040                 1045                 1050             


Gly Pro  Pro Val Leu Pro Arg  Pro Ser Ser Thr Phe  Asn Thr Val 
    1055                 1060                 1065             


Ser Arg  Pro Gln Tyr Gln Asp  Met Val Pro Val Ala  Tyr Asn Asp 
    1070                 1075                 1080             


Lys Ile  Val Ala Phe Leu Arg  Gln Pro Asn Ile Phe  Glu Ile Leu 
    1085                 1090                 1095             


Gln Glu  Arg Gln Pro Asp Leu  Thr Arg Asn His Ser  Leu Arg Glu 
    1100                 1105                 1110             


Lys Ile  Gln Phe Ile Arg Thr  Glu Gly Thr Pro Gly  Leu Val Arg 
    1115                 1120                 1125             


Leu Ser  Ser Asp Ala Asp Leu  Val Met Leu Leu Ser  Leu Phe Glu 
    1130                 1135                 1140             


Glu Glu  Ile Met Ser Tyr Val  Pro Pro His Ala Leu  Leu His Pro 
    1145                 1150                 1155             


Ser Tyr  Cys Gln Ser Pro Arg  Gly Ser Pro Val Ser  Ser Pro Gln 
    1160                 1165                 1170             


Asn Ser  Pro Gly Thr Gln Arg  Ala Asn Ala Arg Ala  Pro Ala Pro 
    1175                 1180                 1185             


Tyr Lys  Arg Asp Phe Glu Ala  Lys Leu Arg Asn Phe  Tyr Arg Lys 
    1190                 1195                 1200             


Leu Glu  Thr Lys Gly Tyr Gly  Gln Gly Pro Gly Lys  Leu Lys Leu 
    1205                 1210                 1215             


Ile Ile  Arg Arg Asp His Leu  Leu Glu Asp Ala Phe  Asn Gln Ile 
    1220                 1225                 1230             


Met Gly  Tyr Ser Arg Lys Asp  Leu Gln Arg Asn Lys  Leu Tyr Val 
    1235                 1240                 1245             


Thr Phe  Val Gly Glu Glu Gly  Leu Asp Tyr Ser Gly  Pro Ser Arg 
    1250                 1255                 1260             


Glu Phe  Phe Phe Leu Val Ser  Arg Glu Leu Phe Asn  Pro Tyr Tyr 
    1265                 1270                 1275             


Gly Leu  Phe Glu Tyr Ser Ala  Asn Asp Thr Tyr Thr  Val Gln Ile 
    1280                 1285                 1290             


Ser Pro  Met Ser Ala Phe Val  Asp Asn His His Glu  Trp Phe Arg 
    1295                 1300                 1305             


Phe Ser  Gly Arg Ile Leu Gly  Leu Ala Leu Ile His  Gln Tyr Leu 
    1310                 1315                 1320             


Leu Asp  Ala Phe Phe Thr Arg  Pro Phe Tyr Lys Ala  Leu Leu Arg 
    1325                 1330                 1335             


Ile Leu  Cys Asp Leu Ser Asp  Leu Glu Tyr Leu Asp  Glu Glu Phe 
    1340                 1345                 1350             


His Gln  Ser Leu Gln Trp Met  Lys Asp Asn Asp Ile  His Asp Ile 
    1355                 1360                 1365             


Leu Asp  Leu Thr Phe Thr Val  Asn Glu Glu Val Phe  Gly Gln Ile 
    1370                 1375                 1380             


Thr Glu  Arg Glu Leu Lys Pro  Gly Gly Ala Asn Ile  Pro Val Thr 
    1385                 1390                 1395             


Glu Lys  Asn Lys Lys Glu Tyr  Ile Glu Arg Met Val  Lys Trp Arg 
    1400                 1405                 1410             


Ile Glu  Arg Gly Val Val Gln  Gln Thr Glu Ser Leu  Val Arg Gly 
    1415                 1420                 1425             


Phe Tyr  Glu Val Val Asp Ala  Arg Leu Val Ser Val  Phe Asp Ala 
    1430                 1435                 1440             


Arg Glu  Leu Glu Leu Val Ile  Ala Gly Thr Ala Glu  Ile Asp Leu 
    1445                 1450                 1455             


Ser Asp  Trp Arg Asn Asn Thr  Glu Tyr Arg Gly Gly  Tyr His Asp 
    1460                 1465                 1470             


Asn His  Ile Val Ile Arg Trp  Phe Trp Ala Ala Val  Glu Arg Phe 
    1475                 1480                 1485             


Asn Asn  Glu Gln Arg Leu Arg  Leu Leu Gln Phe Val  Thr Gly Thr 
    1490                 1495                 1500             


Ser Ser  Ile Pro Tyr Glu Gly  Phe Ala Ser Leu Arg  Gly Ser Asn 
    1505                 1510                 1515             


Gly Pro  Arg Arg Phe Cys Val  Glu Lys Trp Gly Lys  Ile Thr Ala 
    1520                 1525                 1530             


Leu Pro  Arg Ala His Thr Cys  Phe Asn Arg Leu Asp  Leu Pro Pro 
    1535                 1540                 1545             


Tyr Pro  Ser Phe Ser Met Leu  Tyr Glu Lys Leu Leu  Thr Ala Val 
    1550                 1555                 1560             


Glu Glu  Thr Ser Thr Phe Gly  Leu Glu 
    1565                 1570         


<210>  15
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Gly Arg Val Gln Leu Phe Glu Ile Ser Leu Ser His Gly Arg Val 
1               5                   10                  15      


Val Tyr Ser Pro Gly Glu Pro Leu Ala Gly Thr Val Arg Val Arg Leu 
            20                  25                  30          


Gly Ala Pro Leu Pro Phe Arg Ala Ile Arg Val Thr Cys Ile Gly Ser 
        35                  40                  45              


Cys Gly Val Ser Asn Lys Ala Asn Asp Thr Ala Trp Val Val Glu Glu 
    50                  55                  60                  


Gly Tyr Phe Asn Ser Ser Leu Ser Leu Ala Asp Lys Gly Ser Leu Pro 
65                  70                  75                  80  


Ala Gly Glu His Ser Phe Pro Phe Gln Phe Leu Leu Pro Ala Thr Ala 
                85                  90                  95      


Pro Thr Ser Phe Glu Gly Pro Phe Gly Lys Ile Val His Gln Val Arg 
            100                 105                 110         


Ala Ala Ile His Thr Pro Arg Phe Ser Lys Asp His Lys Cys Ser Leu 
        115                 120                 125             


Val Phe Tyr Ile Leu Ser Pro Leu Asn Leu Asn Ser Ile Pro Asp Ile 
    130                 135                 140                 


Glu Gln Pro Asn Val Ala Ser Ala Thr Lys Lys Phe Ser Tyr Lys Leu 
145                 150                 155                 160 


Val Lys Thr Gly Ser Val Val Leu Thr Ala Ser Thr Asp Leu Arg Gly 
                165                 170                 175     


Tyr Val Val Gly Gln Ala Leu Gln Leu His Ala Asp Val Glu Asn Gln 
            180                 185                 190         


Ser Gly Lys Asp Thr Ser Pro Val Val Ala Ser Leu Leu Gln Lys Val 
        195                 200                 205             


Ser Tyr Lys Ala Lys Arg Trp Ile His Asp Val Arg Thr Ile Ala Glu 
    210                 215                 220                 


Val Glu Gly Ala Gly Val Lys Ala Trp Arg Arg Ala Gln Trp His Glu 
225                 230                 235                 240 


Gln Ile Leu Val Pro Ala Leu Pro Gln Ser Ala Leu Pro Gly Cys Ser 
                245                 250                 255     


Leu Ile His Ile Asp Tyr Tyr Leu Gln Val Ser Leu Lys Ala Pro Glu 
            260                 265                 270         


Ala Thr Val Thr Leu Pro Val Phe Ile Gly Asn Ile Ala Val Asn His 
        275                 280                 285             


Ala Pro Val Ser Pro Arg Pro Gly Leu Gly Leu Pro Pro Gly Ala Pro 
    290                 295                 300                 


Pro Leu Val Val Pro Ser Ala Pro Pro Gln Glu Glu Ala Glu Ala Glu 
305                 310                 315                 320 


Ala Ala Ala Gly Gly Pro His Phe Leu Asp Pro Val Phe Leu Ser Thr 
                325                 330                 335     


Lys Ser His Ser Gln Arg Gln Pro Leu Leu Ala Thr Leu Ser Ser Val 
            340                 345                 350         


Pro Gly Ala Pro Glu Pro Cys Pro Gln Asp Gly Ser Pro Ala Ser His 
        355                 360                 365             


Pro Leu His Pro Pro Leu Cys Ile Ser Thr Gly Ala Thr Val Pro Tyr 
    370                 375                 380                 


Phe Ala Glu Gly Ser Gly Gly Pro Val Pro Thr Thr Ser Thr Leu Ile 
385                 390                 395                 400 


Leu Pro Pro Glu Tyr Ser Ser Trp Gly Tyr Pro Tyr Glu Ala Pro Pro 
                405                 410                 415     


Ser Tyr Glu Gln Ser Cys Gly Gly Val Glu Pro Ser Leu Thr Pro Glu 
            420                 425                 430         


Ser 
    


<210>  16
<211>  434
<212>  PRT
<213>  Mus musculus

<400>  16

Met Gly Arg Val Gln Leu Phe Glu Ile Arg Leu Ser Gln Gly Arg Val 
1               5                   10                  15      


Val Tyr Gly Pro Gly Glu Pro Leu Ala Gly Thr Val His Leu Arg Leu 
            20                  25                  30          


Gly Ala Pro Leu Pro Phe Arg Ala Ile Arg Val Thr Cys Met Gly Ser 
        35                  40                  45              


Cys Gly Val Ser Thr Lys Ala Asn Asp Gly Ala Trp Val Val Glu Glu 
    50                  55                  60                  


Ser Tyr Phe Asn Ser Ser Leu Ser Leu Ala Asp Lys Gly Ser Leu Pro 
65                  70                  75                  80  


Ala Gly Glu His Asn Phe Pro Phe Gln Phe Leu Leu Pro Ala Thr Ala 
                85                  90                  95      


Pro Thr Ser Phe Glu Gly Pro Phe Gly Lys Ile Val His Gln Val Arg 
            100                 105                 110         


Ala Ser Ile Asp Thr Pro Arg Phe Ser Lys Asp His Lys Cys Ser Leu 
        115                 120                 125             


Val Phe Tyr Ile Leu Ser Pro Leu Asn Leu Asn Ser Ile Pro Asp Ile 
    130                 135                 140                 


Glu Gln Pro Asn Val Ala Ser Thr Thr Lys Lys Phe Ser Tyr Lys Leu 
145                 150                 155                 160 


Val Lys Thr Gly Asn Val Val Leu Thr Ala Ser Thr Asp Leu Arg Gly 
                165                 170                 175     


Tyr Val Val Gly Gln Val Leu Arg Leu Gln Ala Asp Ile Glu Asn Gln 
            180                 185                 190         


Ser Gly Lys Asp Thr Ser Pro Val Val Ala Ser Leu Leu Gln Lys Val 
        195                 200                 205             


Ser Tyr Lys Ala Lys Arg Trp Ile Tyr Asp Val Arg Thr Ile Ala Glu 
    210                 215                 220                 


Val Glu Gly Thr Gly Val Lys Ala Trp Arg Arg Ala Gln Trp Gln Glu 
225                 230                 235                 240 


Gln Ile Leu Val Pro Ala Leu Pro Gln Ser Ala Leu Pro Gly Cys Ser 
                245                 250                 255     


Leu Ile His Ile Asp Tyr Tyr Leu Gln Val Ser Met Lys Ala Pro Glu 
            260                 265                 270         


Ala Thr Val Thr Leu Pro Leu Phe Val Gly Asn Ile Ala Val Asn Gln 
        275                 280                 285             


Thr Pro Leu Ser Pro Cys Pro Gly Arg Glu Ser Ser Pro Gly Thr Leu 
    290                 295                 300                 


Ser Leu Val Val Pro Ser Ala Pro Pro Gln Glu Glu Ala Glu Ala Val 
305                 310                 315                 320 


Ala Ser Gly Pro His Phe Ser Asp Pro Val Ser Leu Ser Thr Lys Ser 
                325                 330                 335     


His Ser Gln Gln Gln Pro Leu Ser Ala Pro Leu Gly Ser Val Ser Val 
            340                 345                 350         


Thr Thr Thr Glu Pro Trp Val Gln Val Gly Ser Pro Ala Arg His Ser 
        355                 360                 365             


Leu His Pro Pro Leu Cys Ile Ser Ile Gly Ala Thr Val Pro Tyr Phe 
    370                 375                 380                 


Ala Glu Gly Ser Ala Gly Pro Val Pro Thr Thr Ser Ala Leu Ile Leu 
385                 390                 395                 400 


Pro Pro Glu Tyr Ser Ser Trp Gly Tyr Pro Tyr Glu Ala Pro Pro Ser 
                405                 410                 415     


Tyr Glu Gln Ser Cys Gly Ala Ala Gly Thr Asp Leu Gly Leu Ile Pro 
            420                 425                 430         


Gly Ser 
        


<210>  17
<211>  433
<212>  PRT
<213>  Mus musculus

<400>  17

Met Gly Arg Val Gln Leu Phe Glu Ile Arg Leu Ser Gln Gly Arg Val 
1               5                   10                  15      


Val Tyr Gly Pro Gly Glu Pro Leu Ala Gly Thr Val His Leu Arg Leu 
            20                  25                  30          


Gly Ala Pro Leu Pro Phe Arg Ala Ile Arg Val Thr Cys Met Gly Ser 
        35                  40                  45              


Cys Gly Val Ser Thr Lys Ala Asn Asp Gly Ala Trp Val Val Glu Glu 
    50                  55                  60                  


Ser Tyr Phe Asn Ser Ser Leu Ser Leu Ala Asp Lys Gly Ser Leu Pro 
65                  70                  75                  80  


Ala Gly Glu His Asn Phe Pro Phe Gln Phe Leu Leu Pro Ala Thr Ala 
                85                  90                  95      


Pro Thr Ser Phe Glu Gly Pro Phe Gly Lys Ile Val His Gln Val Arg 
            100                 105                 110         


Ala Ser Ile Asp Thr Pro Arg Phe Ser Lys Asp His Lys Cys Ser Leu 
        115                 120                 125             


Val Phe Tyr Ile Leu Ser Pro Leu Asn Leu Asn Ser Ile Pro Asp Ile 
    130                 135                 140                 


Glu Gln Pro Asn Val Ala Ser Thr Thr Lys Lys Phe Ser Tyr Lys Leu 
145                 150                 155                 160 


Val Lys Thr Gly Asn Val Val Leu Thr Ala Ser Thr Asp Leu Arg Gly 
                165                 170                 175     


Tyr Val Val Gly Gln Val Leu Arg Leu Gln Ala Asp Ile Glu Asn Gln 
            180                 185                 190         


Ser Gly Lys Asp Thr Ser Pro Val Val Ala Ser Leu Leu Gln Val Ser 
        195                 200                 205             


Tyr Lys Ala Lys Arg Trp Ile Tyr Asp Val Arg Thr Ile Ala Glu Val 
    210                 215                 220                 


Glu Gly Thr Gly Val Lys Ala Trp Arg Arg Ala Gln Trp Gln Glu Gln 
225                 230                 235                 240 


Ile Leu Val Pro Ala Leu Pro Gln Ser Ala Leu Pro Gly Cys Ser Leu 
                245                 250                 255     


Ile His Ile Asp Tyr Tyr Leu Gln Val Ser Met Lys Ala Pro Glu Ala 
            260                 265                 270         


Thr Val Thr Leu Pro Leu Phe Val Gly Asn Ile Ala Val Asn Gln Thr 
        275                 280                 285             


Pro Leu Ser Pro Cys Pro Gly Arg Glu Ser Ser Pro Gly Thr Leu Ser 
    290                 295                 300                 


Leu Val Val Pro Ser Ala Pro Pro Gln Glu Glu Ala Glu Ala Val Ala 
305                 310                 315                 320 


Ser Gly Pro His Phe Ser Asp Pro Val Ser Leu Ser Thr Lys Ser His 
                325                 330                 335     


Ser Gln Gln Gln Pro Leu Ser Ala Pro Leu Gly Ser Val Ser Val Thr 
            340                 345                 350         


Thr Thr Glu Pro Trp Val Gln Val Gly Ser Pro Ala Arg His Ser Leu 
        355                 360                 365             


His Pro Pro Leu Cys Ile Ser Ile Gly Ala Thr Val Pro Tyr Phe Ala 
    370                 375                 380                 


Glu Gly Ser Ala Gly Pro Val Pro Thr Thr Ser Ala Leu Ile Leu Pro 
385                 390                 395                 400 


Pro Glu Tyr Ser Ser Trp Gly Tyr Pro Tyr Glu Ala Pro Pro Ser Tyr 
                405                 410                 415     


Glu Gln Ser Cys Gly Ala Ala Gly Thr Asp Leu Gly Leu Ile Pro Gly 
            420                 425                 430         


Ser 
    


<210>  18
<211>  65
<212>  PRT
<213>  Homo sapiens

<400>  18

Pro Leu Pro Pro Gly Trp Glu Gln Arg Val Asp Gln His Gly Arg Val 
1               5                   10                  15      


Tyr Tyr Val Asp His Val Glu Lys Arg Thr Thr Trp Asp Arg Pro Glu 
            20                  25                  30          


Pro Leu Pro Pro Gly Trp Glu Arg Arg Val Asp Asn Met Gly Arg Ile 
        35                  40                  45              


Tyr Tyr Val Asp His Phe Thr Arg Thr Thr Thr Trp Gln Arg Pro Thr 
    50                  55                  60                  


Leu 
65  


<210>  19
<211>  185
<212>  PRT
<213>  Homo sapiens

<400>  19

Pro Leu Pro Pro Gly Trp Glu Gln Arg Val Asp Gln His Gly Arg Val 
1               5                   10                  15      


Tyr Tyr Val Asp His Val Glu Lys Arg Thr Thr Trp Asp Arg Pro Glu 
            20                  25                  30          


Pro Leu Pro Pro Gly Trp Glu Arg Arg Val Asp Asn Met Gly Arg Ile 
        35                  40                  45              


Tyr Tyr Val Asp His Phe Thr Arg Thr Thr Thr Trp Gln Arg Pro Thr 
    50                  55                  60                  


Leu Glu Ser Val Arg Asn Tyr Glu Gln Trp Gln Leu Gln Arg Ser Gln 
65                  70                  75                  80  


Leu Gln Gly Ala Met Gln Gln Phe Asn Gln Arg Phe Ile Tyr Gly Asn 
                85                  90                  95      


Gln Asp Leu Phe Ala Thr Ser Gln Ser Lys Glu Phe Asp Pro Leu Gly 
            100                 105                 110         


Pro Leu Pro Pro Gly Trp Glu Lys Arg Thr Asp Ser Asn Gly Arg Val 
        115                 120                 125             


Tyr Phe Val Asn His Asn Thr Arg Ile Thr Gln Trp Glu Asp Pro Arg 
    130                 135                 140                 


Ser Gln Gly Gln Leu Asn Glu Lys Pro Leu Pro Glu Gly Trp Glu Met 
145                 150                 155                 160 


Arg Phe Thr Val Asp Gly Ile Pro Tyr Phe Val Asp His Asn Arg Arg 
                165                 170                 175     


Thr Thr Thr Tyr Ile Asp Pro Arg Thr 
            180                 185 


<210>  20
<211>  390
<212>  PRT
<213>  Mus musculus

<400>  20

Met Ala Val Ser Glu Ser Gln Leu Lys Lys Met Val Ser Lys Tyr Lys 
1               5                   10                  15      


Tyr Arg Asp Leu Thr Val Arg Glu Thr Val Asn Val Ile Thr Leu Tyr 
            20                  25                  30          


Lys Asp Leu Lys Pro Val Leu Asp Ser Tyr Val Phe Asn Asp Gly Ser 
        35                  40                  45              


Ser Arg Glu Leu Met Asn Leu Thr Gly Thr Ile Pro Val Pro Tyr Arg 
    50                  55                  60                  


Gly Asn Thr Tyr Asn Ile Pro Ile Cys Leu Trp Leu Leu Asp Thr Tyr 
65                  70                  75                  80  


Pro Tyr Asn Pro Pro Ile Cys Phe Val Lys Pro Thr Ser Ser Met Thr 
                85                  90                  95      


Ile Lys Thr Gly Lys His Val Asp Ala Asn Gly Lys Ile Tyr Leu Pro 
            100                 105                 110         


Tyr Leu His Glu Trp Lys His Pro Gln Ser Asp Leu Leu Gly Leu Ile 
        115                 120                 125             


Gln Val Met Ile Val Val Phe Gly Asp Glu Pro Pro Val Phe Ser Arg 
    130                 135                 140                 


Pro Ile Ser Ala Ser Tyr Pro Pro Tyr Gln Ala Thr Gly Pro Pro Asn 
145                 150                 155                 160 


Thr Ser Tyr Met Pro Gly Met Pro Gly Gly Ile Ser Pro Tyr Pro Ser 
                165                 170                 175     


Gly Tyr Pro Pro Asn Pro Ser Gly Tyr Pro Gly Cys Pro Tyr Pro Pro 
            180                 185                 190         


Gly Gly Pro Tyr Pro Ala Thr Thr Ser Ser Gln Tyr Pro Ser Gln Pro 
        195                 200                 205             


Pro Val Thr Thr Val Gly Pro Ser Arg Asp Gly Thr Ile Ser Glu Asp 
    210                 215                 220                 


Thr Ile Arg Ala Ser Leu Ile Ser Ala Val Ser Asp Lys Leu Arg Trp 
225                 230                 235                 240 


Arg Met Lys Glu Glu Met Asp Arg Ala Gln Ala Glu Leu Asn Ala Leu 
                245                 250                 255     


Lys Arg Thr Glu Glu Asp Leu Lys Lys Gly His Gln Lys Leu Glu Glu 
            260                 265                 270         


Met Val Thr Arg Leu Asp Gln Glu Val Ala Glu Val Asp Lys Asn Ile 
        275                 280                 285             


Glu Leu Leu Lys Lys Lys Asp Glu Glu Leu Ser Ser Ala Leu Glu Lys 
    290                 295                 300                 


Met Glu Asn Gln Ser Glu Asn Asn Asp Ile Asp Glu Val Ile Ile Pro 
305                 310                 315                 320 


Thr Ala Pro Leu Tyr Lys Gln Ile Leu Asn Leu Tyr Ala Glu Glu Asn 
                325                 330                 335     


Ala Ile Glu Asp Thr Ile Phe Tyr Leu Gly Glu Ala Leu Arg Arg Gly 
            340                 345                 350         


Val Ile Asp Leu Asp Val Phe Leu Lys His Val Arg Leu Leu Ser Arg 
        355                 360                 365             


Lys Gln Phe Gln Leu Arg Ala Leu Met Gln Lys Ala Arg Lys Thr Ala 
    370                 375                 380                 


Gly Leu Ser Asp Leu Tyr 
385                 390 


<210>  21
<211>  391
<212>  PRT
<213>  Mus musculus

<400>  21

Met Ala Val Ser Glu Ser Gln Leu Lys Lys Met Met Ser Lys Tyr Lys 
1               5                   10                  15      


Tyr Arg Asp Leu Thr Val Arg Gln Thr Val Asn Val Ile Ala Met Tyr 
            20                  25                  30          


Lys Asp Leu Lys Pro Val Leu Asp Ser Tyr Val Phe Asn Asp Gly Ser 
        35                  40                  45              


Ser Arg Glu Leu Val Asn Leu Thr Gly Thr Ile Pro Val Arg Tyr Arg 
    50                  55                  60                  


Gly Asn Ile Tyr Asn Ile Pro Ile Cys Leu Trp Leu Leu Asp Thr Tyr 
65                  70                  75                  80  


Pro Tyr Asn Pro Pro Ile Cys Phe Val Lys Pro Thr Ser Ser Met Thr 
                85                  90                  95      


Ile Lys Thr Gly Lys His Val Asp Ala Asn Gly Lys Ile Tyr Leu Pro 
            100                 105                 110         


Tyr Leu His Asp Trp Lys His Pro Arg Ser Glu Leu Leu Glu Leu Ile 
        115                 120                 125             


Gln Ile Met Ile Val Ile Phe Gly Glu Glu Pro Pro Val Phe Ser Arg 
    130                 135                 140                 


Pro Thr Val Ser Ala Ser Tyr Pro Pro Tyr Thr Ala Thr Gly Pro Pro 
145                 150                 155                 160 


Asn Thr Ser Tyr Met Pro Gly Met Pro Ser Gly Ile Ser Ala Tyr Pro 
                165                 170                 175     


Ser Gly Tyr Pro Pro Asn Pro Ser Gly Tyr Pro Gly Cys Pro Tyr Pro 
            180                 185                 190         


Pro Ala Gly Pro Tyr Pro Ala Thr Thr Ser Ser Gln Tyr Pro Ser Gln 
        195                 200                 205             


Pro Pro Val Thr Thr Val Gly Pro Ser Arg Asp Gly Thr Ile Ser Glu 
    210                 215                 220                 


Asp Thr Ile Arg Ala Ser Leu Ile Ser Ala Val Ser Asp Lys Leu Arg 
225                 230                 235                 240 


Trp Arg Met Lys Glu Glu Met Asp Gly Ala Gln Ala Glu Leu Asn Ala 
                245                 250                 255     


Leu Lys Arg Thr Glu Glu Asp Leu Lys Lys Gly His Gln Lys Leu Glu 
            260                 265                 270         


Glu Met Val Thr Arg Leu Asp Gln Glu Val Ala Glu Val Asp Lys Asn 
        275                 280                 285             


Ile Glu Leu Leu Lys Lys Lys Asp Glu Glu Leu Ser Ser Ala Leu Glu 
    290                 295                 300                 


Lys Met Glu Asn Gln Ser Glu Asn Asn Asp Ile Asp Glu Val Ile Ile 
305                 310                 315                 320 


Pro Thr Ala Pro Leu Tyr Lys Gln Ile Leu Asn Leu Tyr Ala Glu Glu 
                325                 330                 335     


Asn Ala Ile Glu Asp Thr Ile Phe Tyr Leu Gly Glu Ala Leu Arg Arg 
            340                 345                 350         


Gly Val Ile Asp Leu Asp Val Phe Leu Lys His Val Arg Leu Leu Ser 
        355                 360                 365             


Arg Lys Gln Phe Gln Leu Arg Ala Leu Met Gln Lys Ala Arg Lys Thr 
    370                 375                 380                 


Ala Gly Leu Ser Asp Leu Tyr 
385                 390     


<210>  22
<211>  391
<212>  PRT
<213>  Rattus norvegicus

<400>  22

Met Ala Val Ser Glu Ser Gln Leu Lys Lys Met Met Ser Lys Tyr Lys 
1               5                   10                  15      


Tyr Arg Asp Leu Thr Val Arg Gln Thr Val Asn Val Ile Ala Met Tyr 
            20                  25                  30          


Lys Asp Leu Lys Pro Val Leu Asp Ser Tyr Val Phe Asn Asp Gly Ser 
        35                  40                  45              


Ser Arg Glu Leu Val Asn Leu Thr Gly Thr Ile Pro Val Arg Tyr Arg 
    50                  55                  60                  


Gly Asn Ile Tyr Asn Ile Pro Ile Cys Leu Trp Leu Leu Asp Thr Tyr 
65                  70                  75                  80  


Pro Tyr Asn Pro Pro Ile Cys Phe Val Lys Pro Thr Ser Ser Met Thr 
                85                  90                  95      


Ile Lys Thr Gly Lys His Val Asp Ala Asn Gly Lys Ile Tyr Leu Pro 
            100                 105                 110         


Tyr Leu His Asp Trp Lys His Pro Arg Ser Glu Leu Leu Glu Leu Ile 
        115                 120                 125             


Gln Ile Met Ile Val Ile Phe Gly Glu Glu Pro Pro Val Phe Ser Arg 
    130                 135                 140                 


Pro Thr Val Ser Ala Ser Tyr Pro Pro Tyr Thr Ala Ala Gly Pro Pro 
145                 150                 155                 160 


Asn Thr Ser Tyr Leu Pro Ser Met Pro Ser Gly Ile Ser Ala Tyr Pro 
                165                 170                 175     


Ser Gly Tyr Pro Pro Asn Pro Ser Gly Tyr Pro Gly Cys Pro Tyr Pro 
            180                 185                 190         


Pro Ala Gly Pro Tyr Pro Ala Thr Thr Ser Ser Gln Tyr Pro Ser Gln 
        195                 200                 205             


Pro Pro Val Thr Thr Ala Gly Pro Ser Arg Asp Gly Thr Ile Ser Glu 
    210                 215                 220                 


Asp Thr Ile Arg Ala Ser Leu Ile Ser Ala Val Ser Asp Lys Leu Arg 
225                 230                 235                 240 


Trp Arg Met Lys Glu Glu Met Asp Gly Ala Gln Ala Glu Leu Asn Ala 
                245                 250                 255     


Leu Lys Arg Thr Glu Glu Asp Leu Lys Lys Gly His Gln Lys Leu Glu 
            260                 265                 270         


Glu Met Val Thr Arg Leu Asp Gln Glu Val Ala Glu Val Asp Lys Asn 
        275                 280                 285             


Ile Glu Leu Leu Lys Lys Lys Asp Glu Glu Leu Ser Ser Ala Leu Glu 
    290                 295                 300                 


Lys Met Glu Asn Gln Ser Glu Asn Asn Asp Ile Asp Glu Val Ile Ile 
305                 310                 315                 320 


Pro Thr Ala Pro Leu Tyr Lys Gln Ile Leu Asn Leu Tyr Ala Glu Glu 
                325                 330                 335     


Asn Ala Ile Glu Asp Thr Ile Phe Tyr Leu Gly Glu Ala Leu Arg Arg 
            340                 345                 350         


Gly Val Ile Asp Leu Asp Val Phe Leu Lys His Val Arg Leu Leu Ser 
        355                 360                 365             


Arg Lys Gln Phe Gln Leu Arg Ala Leu Met Gln Lys Ala Arg Lys Thr 
    370                 375                 380                 


Ala Gly Leu Ser Asp Leu Tyr 
385                 390     


<210>  23
<211>  3475
<212>  DNA
<213>  Homo sapiens

<400>  23
gaattcgcgg ccgcgtcgac cgcttctgtg gccacggcag atgaaacaga aaggctaaag       60

agggctggag tcaggggact tctcttccac cagcttcacg gtgatgatat ggcatctgcc      120

agctctagcc gggcaggagt ggccctgcct tttgagaagt ctcagctcac tttgaaagtg      180

gtgtccgcaa agcccaaggt gcataatcgt caacctcgaa ttaactccta cgtggaggtg      240

gcggtggatg gactccccag tgagaccaag aagactggga agcgcattgg gagctctgag      300

cttctctgga atgagatcat cattttgaat gtcacggcac agagtcattt agatttaaag      360

gtctggagct gccatacctt gagaaatgaa ctgctaggca ccgcatctgt caacctctcc      420

aacgtcttga agaacaatgg gggcaaaatg gagaacatgc agctgaccct gaacctgcag      480

acggagaaca aaggcagcgt tgtctcaggc ggaaaactga caattttcct ggacgggcca      540

actgttgatc tgggaaatgt gcctaatggc agtgccctga cagatggatc acagctgcct      600

tcgagagact ccagtggaac agcagtagct ccagagaacc ggcaccagcc ccccagcaca      660

aactgctttg gtggaagatc ccggacgcac agacattcgg gtgcttcagc cagaacaacc      720

ccagcaaccg gcgagcaaag ccccggtgct cggagccggc accgccagcc cgtcaagaac      780

tcaggccaca gtggcttggc caatggcaca gtgaatgatg aacccacaac agccactgat      840

cccgaagaac cttccgttgt tggtgtgacg tccccacctg ctgcaccctt gagtgtgacc      900

ccgaatccca acacgacttc tctccctgcc ccagccacac cggctgaagg agaggaaccc      960

agcacttcgg gtacacagca gctcccagcg gctgcccagg cccccgacgc tctgcctgct     1020

ggatgggaac agcgagagct gcccaacgga cgtgtctatt atgttgacca caataccaag     1080

accaccacct gggagcggcc ccttcctcca ggctgggaaa aacgcacaga tccccgaggc     1140

aggttttact atgtggatca caatactcgg accaccacct ggcagcgtcc gaccgcggag     1200

tacgtgcgca actatgagca gtggcagtcg cagcggaatc agctccaggg ggccatgcag     1260

cacttcagcc aaagattcct ataccagttt tggagtgctt cgactgacca tgatcccctg     1320

ggccccctcc ctcctggttg ggagaaaaga caggacaatg gacgggtgta ttacgtgaac     1380

cataacactc gcacgaccca gtgggaggat ccccggaccc aggggatgat ccaggaacca     1440

gctttgcccc caggatggga gatgaaatac accagcgagg gggtgcgata ctttgtggac     1500

cacaataccc gcaccaccac ctttaaggat cctcgcccgg ggtttgagtc ggggacgaag     1560

caaggttccc ctggtgctta tgaccgcagt tttcggtgga agtatcacca gttccgtttc     1620

ctctgccatt caaatgccct acctagccac gtgaagatca gcgtttccag gcagacgctt     1680

ttcgaagatt ccttccaaca gatcatgaac atgaaaccct atgacctgcg ccgccggctt     1740

tacatcatca tgcgtggcga ggagggcctg gactatgggg gcatcgccag agagtggttt     1800

ttcctcctgt ctcacgaggt gctcaaccct atgtattgtt tatttgaata tgccggaaag     1860

aacaattact gcctgcagat caaccccgcc tcctccatca acccggacca cctcacctac     1920

tttcgcttta taggcagatt catcgccatg gcgctgtacc atggaaagtt catcgacacg     1980

ggcttcaccc tccctttcta caagcggatg ctcaataaga gaccaaccct gaaagacctg     2040

gagtccattg accctgagtt ctacaactcc attgtctgga tcaaagagaa caacctggaa     2100

gaatgtggcc tggagctgta cttcatccag gacatggaga tactgggcaa ggtgacgacc     2160

cacgagctga aggagggcgg cgagagcatc cgggtcacgg aggagaacaa ggaagagtac     2220

atcatgctgc tgactgactg gcgtttcacc cgaggcgtgg aagagcagac caaagccttc     2280

ctggatggct tcaacgaggt ggccccgctg gagtggctgc gctactttga cgagaaagag     2340

ctggagctga tgctgtgcgg catgcaggag atagacatga gcgactggca gaagagcacc     2400

atctaccggc actacaccaa gaacagcaag cagatccagt ggttctggca ggtggtgaag     2460

gagatggaca acgagaagag gatccggctg ctgcagtttg tcaccggtac ctgccgcctg     2520

cccgtcgggg gatttgccga actcatcggt agcaacggac cacagaagtt ttgcattgac     2580

aaagttggca aggaaacctg gctgcccaga agccacacct gcttcaaccg tctggatctt     2640

ccaccctaca agagctacga acagctgaga gagaagctgc tgtatgccat tgaggagacc     2700

gagggctttg gacaggagta accgaggccg cccctcccac gccccccagc gcacatgtag     2760

tcctgagtcc tccctgcctg agaggccact ggccccgcag cccttgggag gcccccgtgg     2820

atgtggccct gtgtgggacc acactgtcat ctcgctgctg gcagaaaagc ctgatcccag     2880

gaggccctgc agttcccccg acccgcggat ggcagtctgg aataaagccc cctagttgcc     2940

tttggcccca cctttgcaaa gttccagagg gctgaccctc tctgcaaaac tctcccctgt     3000

cctctagacc ccaccctggg tgtatgtgag tgtgcaaggg aaggtgttgc atccccaggg     3060

gctgccgcag aggccggaga cctcctggac tagttcggcg aggagactgg ccactggggg     3120

tggctgttcg ggactgagag cgccaagggt ctttgccagc aaaggaggtt ctgcctgtaa     3180

ttgagcctct ctgatgatgg agatgaagtg aaggtctgag ggacgggccc tggggctagg     3240

ccatctctgc ctgcctccct agcaggcgcc agcggtggag gctgagtcgc aggacacatg     3300

ccggccagtt aattcattct cagcaaatga aggtttgtct aagctgcctg ggtatccacg     3360

ggacaaaaac agcaaactcc ctccagactt tgtccatgtt ataaacttga aagttggttg     3420

ttgtttgtta ggtttgccag gtttttttgt ttacgcctgc tgtcactttc ctgtc          3475


<210>  24
<211>  3475
<212>  DNA
<213>  Homo sapiens

<400>  24
gaattcgcgg ccgcgtcgac cgcttctgtg gccacggcag atgaaacaga aaggctaaag       60

agggctggag tcaggggact tctcttccac cagcttcacg gtgatgatat ggcatctgcc      120

agctctagcc gggcaggagt ggccctgcct tttgagaagt ctcagctcac tttgaaagtg      180

gtgtccgcaa agcccaaggt gcataatcgt caacctcgaa ttaactccta cgtggaggtg      240

gcggtggatg gactccccag tgagaccaag aagactggga agcgcattgg gagctctgag      300

cttctctgga atgagatcat cattttgaat gtcacggcac agagtcattt agatttaaag      360

gtctggagct gccatacctt gagaaatgaa ctgctaggca ccgcatctgt caacctctcc      420

aacgtcttga agaacaatgg gggcaaaatg gagaacatgc agctgaccct gaacctgcag      480

acggagaaca aaggcagcgt tgtctcaggc ggaaaactga caattttcct ggacgggcca      540

actgttgatc tgggaaatgt gcctaatggc agtgccctga cagatggatc acagctgcct      600

tcgagagact ccagtggaac agcagtagct ccagagaacc ggcaccagcc ccccagcaca      660

aactgctttg gtggaagatc ccggacgcac agacattcgg gtgcttcagc cagaacaacc      720

ccagcaaccg gcgagcaaag ccccggtgct cggagccggc accgccagcc cgtcaagaac      780

tcaggccaca gtggcttggc caatggcaca gtgaatgatg aacccacaac agccactgat      840

cccgaagaac cttccgttgt tggtgtgacg tccccacctg ctgcaccctt gagtgtgacc      900

ccgaatccca acacgacttc tctccctgcc ccagccacac cggctgaagg agaggaaccc      960

agcacttcgg gtacacagca gctcccagcg gctgcccagg cccccgacgc tctgcctgct     1020

ggatgggaac agcgagagct gcccaacgga cgtgtctatt atgttgacca caataccaag     1080

accaccacct gggagcggcc ccttcctcca ggctgggaaa aacgcacaga tccccgaggc     1140

aggttttact atgtggatca caatactcgg accaccacct ggcagcgtcc gaccgcggag     1200

tacgtgcgca actatgagca gtggcagtcg cagcggaatc agctccaggg ggccatgcag     1260

cacttcagcc aaagattcct ataccagttt tggagtgctt cgactgacca tgatcccctg     1320

ggccccctcc ctcctggttg ggagaaaaga caggacaatg gacgggtgta ttacgtgaac     1380

cataacactc gcacgaccca gtgggaggat ccccggaccc aggggatgat ccaggaacca     1440

gctttgcccc caggatggga gatgaaatac accagcgagg gggtgcgata ctttgtggac     1500

cacaataccc gcaccaccac ctttaaggat cctcgcccgg ggtttgagtc ggggacgaag     1560

caaggttccc ctggtgctta tgaccgcagt tttcggtgga agtatcacca gttccgtttc     1620

ctctgccatt caaatgccct acctagccac gtgaagatca gcgtttccag gcagacgctt     1680

ttcgaagatt ccttccaaca gatcatgaac atgaaaccct atgacctgcg ccgccggctt     1740

tacatcatca tgcgtggcga ggagggcctg gactatgggg gcatcgccag agagtggttt     1800

ttcctcctgt ctcacgaggt gctcaaccct atgtattgtt tatttgaata tgccggaaag     1860

aacaattact gcctgcagat caaccccgcc tcctccatca acccggacca cctcacctac     1920

tttcgcttta taggcagatt catcgccatg gcgctgtacc atggaaagtt catcgacacg     1980

ggcttcaccc tccctttcta caagcggatg ctcaataaga gaccaaccct gaaagacctg     2040

gagtccattg accctgagtt ctacaactcc attgtctgga tcaaagagaa caacctggaa     2100

gaatgtggcc tggagctgta cttcatccag gacatggaga tactgggcaa ggtgacgacc     2160

cacgagctga aggagggcgg cgagagcatc cgggtcacgg aggagaacaa ggaagagtac     2220

atcatgctgc tgactgactg gcgtttcacc cgaggcgtgg aagagcagac caaagccttc     2280

ctggatggct tcaacgaggt ggccccgctg gagtggctgc gctactttga cgagaaagag     2340

ctggagctga tgctgtgcgg catgcaggag atagacatga gcgactggca gaagagcacc     2400

atctaccggc actacaccaa gaacagcaag cagatccagt ggttctggca ggtggtgaag     2460

gagatggaca acgagaagag gatccggctg ctgcagtttg tcaccggtac ctgccgcctg     2520

cccgtcgggg gatttgccga actcatcggt agcaacggac cacagaagtt ttgcattgac     2580

aaagttggca aggaaacctg gctgcccaga agccacacct gcttcaaccg tctggatctt     2640

ccaccctaca agagctacga acagctgaga gagaagctgc tgtatgccat tgaggagacc     2700

gagggctttg gacaggagta accgaggccg cccctcccac gccccccagc gcacatgtag     2760

tcctgagtcc tccctgcctg agaggccact ggccccgcag cccttgggag gcccccgtgg     2820

atgtggccct gtgtgggacc acactgtcat ctcgctgctg gcagaaaagc ctgatcccag     2880

gaggccctgc agttcccccg acccgcggat ggcagtctgg aataaagccc cctagttgcc     2940

tttggcccca cctttgcaaa gttccagagg gctgaccctc tctgcaaaac tctcccctgt     3000

cctctagacc ccaccctggg tgtatgtgag tgtgcaaggg aaggtgttgc atccccaggg     3060

gctgccgcag aggccggaga cctcctggac tagttcggcg aggagactgg ccactggggg     3120

tggctgttcg ggactgagag cgccaagggt ctttgccagc aaaggaggtt ctgcctgtaa     3180

ttgagcctct ctgatgatgg agatgaagtg aaggtctgag ggacgggccc tggggctagg     3240

ccatctctgc ctgcctccct agcaggcgcc agcggtggag gctgagtcgc aggacacatg     3300

ccggccagtt aattcattct cagcaaatga aggtttgtct aagctgcctg ggtatccacg     3360

ggacaaaaac agcaaactcc ctccagactt tgtccatgtt ataaacttga aagttggttg     3420

ttgtttgtta ggtttgccag gtttttttgt ttacgcctgc tgtcactttc ctgtc          3475


<210>  25
<211>  2914
<212>  DNA
<213>  Homo sapiens

<400>  25
acagttgcct gccctgggcg ggggcgagcg cgtccggttt gctggaagcg ttcggaaatg       60

gcaacttgcg cggtggaggt gttcgggctc ctggaggacg aggaaaattc acgaattgtg      120

agagtaagag ttatagccgg aataggcctt gccaagaagg atatattggg agctagtgat      180

ccttacgtga gagtgacgtt atatgaccca atgaatggag ttcttacaag tgtgcaaaca      240

aaaaccatta aaaagagttt gaatccaaag tggaatgaag aaatattatt cagagttcat      300

cctcagcagc accggcttct ttttgaagtg tttgacgaaa accgattgac aagagatgat      360

ttcctaggtc aagtggatgt tccactttat ccattaccga cagaaaatcc aagattggag      420

agaccatata catttaagga ttttgttctt catccaagaa gtcacaaatc aagagttaaa      480

ggttatctga gactaaaaat gacttattta cctaaaacca gtggctcaga agatgataat      540

gcagaacagg ctgaggaatt agagcctggc tgggttgttt tggaccaacc agatgctgct      600

tgccatttgc agcaacaaca agaaccttct cctctacctc cagggtggga agagaggcag      660

gatatccttg gaaggaccta ttatgtaaac catgaatcta gaagaacaca gtggaaaaga      720

ccaacccctc aggacaacct aacagatgct gagaatggca acattcaact gcaagcacaa      780

cgtgcattta ccaccaggcg gcagatatcc gaggaaacag aaagtgttga caaccaagag      840

tcttccgaga actgggaaat tataagagaa gatgaagcca ccatgtatag cagccaggcc      900

ttcccatcac ctccaccgtc aagtaacttg gatgttccaa ctcatcttgc agaagaattg      960

aatgccagac tcaccatttt tggaaattca gccgtgagcc agccagcatc gagctcaaat     1020

cattccagca gaagaggcag cttacaagcc tatacttttg aggaacaacc tacacttcct     1080

gtgcttttgc ctacttcatc tggattacca ccaggttggg aagaaaaaca agatgaaaga     1140

ggaagatcat attatgtaga tcacaattcc agaacgacta cttggacaaa gcccactgta     1200

caggccacag tggagaccag tcagctgacc tcaagccaga gttctgcagg ccctcaatca     1260

caagcctcca ccagtgattc aggccagcag gtgacccagc catctgaaat tgagcaagga     1320

ttccttccta aaggctggga agtccggcat gcaccaaatg ggaggccttt ctttattgac     1380

cacaacacta aaaccaccac ctgggaagat ccaagattga aaattccagc ccatctgaga     1440

ggaaagacat cacttgatac ttccaatgat ctagggcctt tacctccagg atgggaagag     1500

agaactcaca cagatggaag aatcttctac ataaatcaca atataaaaag aacacaatgg     1560

gaagatcctc ggttggagaa tgtagcaata actggaccag cagtgcccta ctccagggat     1620

tacaaaagaa agtatgagtt cttccgaaga aagttgaaga agcagaatga cattccaaac     1680

aaatttgaaa tgaaacttcg ccgagcaact gttcttgaag actcttaccg gagaattatg     1740

ggtgtcaaga gagcagactt cctgaaggct cgactgtgga ttgagtttga tggtgaaaag     1800

ggattggatt atggaggagt tgccagagaa tggttcttcc tgatctcaaa ggaaatgttt     1860

aacccttatt atgggttgtt tgaatattct gctacggaca attataccct acagataaat     1920

ccaaactctg gattgtgtaa cgaagatcac ctctcttact tcaagtttat tggtcgggta     1980

gctggaatgg cagtttatca tggcaaactg ttggatggtt ttttcatccg cccattttac     2040

aagatgatgc ttcacaaacc aataaccctt catgatatgg aatctgtgga tagtgaatat     2100

tacaattccc taagatggat tcttgaaaat gacccaacag aattggacct caggtttatc     2160

atagatgaag aactttttgg acagacacat caacatgagc tgaaaaatgg tggatcagaa     2220

atagttgtca ccaataagaa caaaaaggaa tatatttatc ttgtaataca atggcgattt     2280

gtaaaccgaa tccagaagca aatggctgct tttaaagagg gattctttga actaatacca     2340

caggatctca tcaaaatttt tgatgaaaat gaactagagc ttcttatgtg tggaccggga     2400

gatgttgatg tgaatgactg gagggaacat acaaagtata aaaatggcta cagtgcaaat     2460

catcaggtta tacagtggtt ttggaaggct gttttaatga tggattcaga aaaaagaata     2520

agattacttc agtttgtcac tggcacatct cgggtgccta tgaatggatt tgctgaacta     2580

tacggttcaa atggaccaca gtcatttaca gttgaacagt ggggtactcc tgaaaagctg     2640

ccaagagctc atacctgttt taatcgcctg gacttgccac cttatgaatc atttgaagaa     2700

ttatgggata aacttcagat ggcaattgaa aacacccagg gctttgatgg agttgattag     2760

attacaaata acaatctgta gtgtttttac tgccatagtt ttataaccaa aatcttgact     2820

taaaattttc cggggaacta ctaaaatgtg gccactgagt cttcccagat cttgaagaaa     2880

atcatataaa aagcatttga agaaatagta cgac                                 2914


<210>  26
<211>  2868
<212>  DNA
<213>  Homo sapiens

<400>  26
atggcgaccg ggctcgggga gccggtctat ggactttccg aagacgaggg agagtcccgt       60

attctcagag taaaagttgt ttctggaatt gatctcgcca aaaaggacat ctttggagcc      120

agtgatccgt atgtgaaact ttcattgtac gtagcggatg agaatagaga acttgctttg      180

gtccagacaa aaacaattaa aaagacactg aacccaaaat ggaatgaaga attttatttc      240

agggtaaacc catctaatca cagactccta tttgaagtat ttgacgaaaa tagactgaca      300

cgagacgact tcctgggcca ggtggacgtg ccccttagtc accttccgac agaagatcca      360

accatggagc gaccctatac atttaaggac tttctcctca gaccaagaag tcataagtct      420

cgagttaagg gatttttgcg attgaaaatg gcctatatgc caaaaaatgg aggtcaagat      480

gaagaaaaca gtgaccagag ggatgacatg gagcatggat gggaagttgt tgactcaaat      540

gactcggctt ctcagcacca agaggaactt cctcctcctc ctctgcctcc cgggtgggaa      600

gaaaaagtgg acaatttagg ccgaacttac tatgtcaacc acaacaaccg gaccactcag      660

tggcacagac caagcctgat ggacgtgtcc tcggagtcgg acaataacat cagacagatc      720

aaccaggagg cagcacaccg gcgcttccgc tcccgcaggc acatcagcga agacttggag      780

cccgagccct cggagggcgg ggatgtcccc gagccttggg agaccatttc agaggaagtg      840

aatatcgctg gagactctct cggtctggct ctgcccccac caccggcctc cccaggatct      900

cggaccagcc ctcaggagct gtcagaggaa ctaagcagaa ggcttcagat cactccagac      960

tccaatgggg aacagttcag ctctttgatt caaagagaac cctcctcaag gttgaggtca     1020

tgcagtgtca ccgacgcagt tgcagaacag ggccatctac caccgccatc agtggcctat     1080

gtacatacca cgccgggtct gccttcaggc tgggaagaaa gaaaagatgc taaggggcgc     1140

acatactatg tcaatcataa caatcgaacc acaacttgga ctcgacctat catgcagctt     1200

gcagaagatg gtgcgtccgg atcagccaca aacagtaaca accatctaat cgagcctcag     1260

atccgccggc ctcgtagcct cagctcgcca acagtaactt tatctgcccc gctggagggt     1320

gccaaggact cacccgtacg tcgggctgtg aaagacaccc tttccaaccc acagtcccca     1380

cagccatcac cttacaactc ccccaaacca caacacaaag tcacacagag cttcttgcca     1440

cccggctggg aaatgaggat agcgccaaac ggccggccct tcttcattga tcataacaca     1500

aagactacaa cctgggaaga tccacgtttg aaatttccag tacatatgcg gtcaaagaca     1560

tctttaaacc ccaatgacct tggccccctt cctcctggct gggaagaaag aattcacttg     1620

gatggccgaa cgttttatat tgatcataat agcaaaatta ctcagtggga agacccaaga     1680

ctgcagaacc cagctattac tggtccggct gtcccttact ccagagaatt taagcagaaa     1740

tatgactact tcaggaagaa attaaagaaa cctgctgata tccccaatag gtttgaaatg     1800

aaacttcaca gaaataacat atttgaagag tcctatcgga gaattatgtc cgtgaaaaga     1860

ccagatgtcc taaaagctag actgtggatt gagtttgaat cagagaaagg tcttgactat     1920

gggggtgtgg ccagagaatg gttcttctta ctgtccaaag agatgttcaa cccctactac     1980

ggcctctttg agtactctgc cacggacaac tacacccttc agatcaaccc taattcaggc     2040

ctctgtaatg aggatcattt gtcctacttc acttttattg gaagagttgc tggtctggcc     2100

gtatttcatg ggaagctctt agatggtttc ttcattagac cattttacaa gatgatgttg     2160

ggaaagcaga taaccctgaa tgacatggaa tctgtggata gtgaatatta caactctttg     2220

aaatggatcc tggagaatga ccctactgag ctggacctca tgttctgcat agacgaagaa     2280

aactttggac agacatatca agtggatttg aagcccaatg ggtcagaaat aatggtcaca     2340

aatgaaaaca aaagggaata tatcgactta gtcatccagt ggagatttgt gaacagggtc     2400

cagaagcaga tgaacgcctt cttggaggga ttcacagaac tacttcctat tgatttgatt     2460

aaaatttttg atgaaaatga gctggagttg ctcatgtgcg gcctcggtga tgtggatgtg     2520

aatgactgga gacagcattc tatttacaag aacggctact gcccaaacca ccccgtcatt     2580

cagtggttct ggaaggctgt gctactcatg gacgccgaaa agcgtatccg gttactgcag     2640

tttgtcacag ggacatcgcg agtacctatg aatggatttg ccgaacttta tggttccaat     2700

ggtcctcagc tgtttacaat agagcaatgg ggcagtcctg agaaactgcc cagagctcac     2760

acatgcttta atcgccttga cttacctcca tatgaaacct ttgaagattt acgagagaaa     2820

cttctcatgg ccgtggaaaa tgctcaagga tttgaagggg tggattaa                  2868


<210>  27
<211>  2274
<212>  DNA
<213>  Homo sapiens

<400>  27
atgtcgaacc ccgggacacg caggaacggc tccagcatca agatccgtct gacagtgtta       60

tgtgccaaga accttgcaaa gaaagacttc ttcaggctcc ctgacccttt tgcaaagatt      120

gtcgtggatg ggtctgggca gtgccactca accgacactg tgaaaaacac attggaccca      180

aagtggaacc agcactatga tctatatgtt gggaaaacgg attcgataac cattagcgtg      240

tggaaccata agaaaattca caagaaacag ggagctggct tcctgggctg tgtgcggctg      300

ctctccaatg ccatcagcag attaaaagat accggatacc agcgtttgga tctatgcaaa      360

ctaaacccct cagatactga tgcagttcgt ggccagatag tggtcagttt acagacacga      420

gacagaatag gaaccggcgg ctcggtggtg gactgcagag gactgttaga aaatgaagga      480

acggtgtatg aagactccgg gcctgggagg ccgctcagct gcttcatgga ggaaccagcc      540

ccttacacag atagcaccgg tgctgctgct ggaggaggga attgcaggtt cgtggagtcc      600

ccaagtcaag atcaaagact tcaggcacag cggcttcgaa accctgatgt gcgaggttca      660

ctacagacgc cccagaaccg accacacggc caccagtccc cggaactgcc cgaaggctac      720

gaacaaagaa caacagtcca gggccaagtt tactttttgc atacacagac tggagttagc      780

acgtggcacg accccaggat accaagtccc tcggggacca ttcctggggg agatgcagct      840

tttctatacg aattccttct acaaggccat acatctgagc ccagagacct taacagtgtg      900

aactgtgatg aacttggacc actgccgcca ggctgggaag tcagaagtac agtttctggg      960

aggatatatt ttgtagatca taataaccga acaacccagt ttacagaccc aaggttacac     1020

cacatcatga atcaccagtg ccaactcaag gagcccagcc agccgctgcc actgcccagt     1080

gagggctctc tggaggacga ggagcttcct gcccagagat acgaaagaga tctagtccag     1140

aagctgaaag tcctcagaca cgaactgtcg cttcagcagc cccaagctgg tcattgccgc     1200

atcgaagtgt ccagagaaga aatctttgag gagtcttacc gccagataat gaagatgcga     1260

ccgaaagact tgaaaaaacg gctgatggtg aaattccgtg gggaagaagg tttggattac     1320

ggtggtgtgg ccagggagtg gctttacttg ctgtgccatg aaatgctgaa tccttattac     1380

gggctcttcc agtattctac ggacaatatt tacatgttgc aaataaatcc ggattcttca     1440

atcaaccccg accacttgtc ttatttccac tttgtggggc ggatcatggg gctggctgtg     1500

ttccatggac actacatcaa cgggggcttc acagtgccct tctacaagca gctgctgggg     1560

aagcccatcc agctctcaga tctggaatct gtggacccag agctgcataa gagcttggtg     1620

tggatcctag agaacgacat cacgcctgta ctggaccaca ccttctgcgt ggaacacaac     1680

gccttcgggc ggatcctgca gcatgaactg aaacccaatg gcagaaatgt gccagtcaca     1740

gaggagaata agaaagaata cgtccggttg tatgtaaact ggaggtttat gagaggaatc     1800

gaagcccagt tcttagctct gcagaagggg ttcaatgagc tcatccctca acatctgctg     1860

aagccttttg accagaagga actggagctg atcataggcg gcctggataa aatagacttg     1920

aacgactgga agtcgaacac gcggctgaag cactgtgtgg ccgacagcaa catcgtgcgg     1980

tggttctggc aagcggtgga gacgttcgat gaagaaagga gggccaggct cctgcagttt     2040

gtgactgggt ccacgcgagt cccgctccaa ggcttcaagg ctttgcaagg ttctacaggc     2100

gcggcagggc cccggctgtt caccatccac ctgatagacg cgaacacaga caaccttccg     2160

aaggcccata cctgctttaa ccggatcgac attccaccat atgagtccta tgagaagctc     2220

tacgagaagc tgctgacagc cgtggaggag acctgcgggt ttgctgtgga gtga           2274


<210>  28
<211>  2247
<212>  DNA
<213>  Homo sapiens

<400>  28
atgtctaacc ccggacgccg gaggaacggg cccgtcaagc tgcgcctgac agtactctgt       60

gcaaaaaacc tggtgaaaaa ggattttttc cgacttcctg atccatttgc taaggtggtg      120

gttgatggat ctgggcaatg ccattctaca gatactgtga agaatacgct tgatccaaag      180

tggaatcagc attatgacct gtatattgga aagtctgatt cagttacgat cagtgtatgg      240

aatcacaaga agatccataa gaaacaaggt gctggatttc tcggttgtgt tcgtcttctt      300

tccaatgcca tcaaccgcct caaagacact ggttatcaga ggttggattt atgcaaactc      360

gggccaaatg acaatgatac agttagagga cagatagtag taagtcttca gtccagagac      420

cgaataggca caggaggaca agttgtggac tgcagtcgtt tatttgataa cgatttacca      480

gacggctggg aagaaaggag aaccgcctct ggaagaatcc agtatctaaa ccatataaca      540

agaactacgc aatgggagcg cccaacacga ccggcatccg aatattctag ccctggcaga      600

cctcttagct gctttgttga tgagaacact ccaattagtg gaacaaatgg tgcaacatgt      660

ggacagtctt cagatcccag gctggcagag aggagagtca ggtcacaacg acatagaaat      720

tacatgagca gaacacattt acatactcct ccagacctac cagaaggcta tgaacagagg      780

acaacgcaac aaggccaggt gtatttctta catacacaga ctggtgtgag cacatggcat      840

gatccaagag tgcccaggga tcttagcaac atcaattgtg aagagcttgg tccattgcct      900

cctggatggg agatccgtaa tacggcaaca ggcagagttt atttcgttga ccataacaac      960

agaacaacac aatttacaga tcctcggctg tctgctaact tgcatttagt tttaaatcgg     1020

cagaaccaat tgaaagacca acagcaacag caagtggtat cgttatgtcc tgatgacaca     1080

gaatgcctga cagtcccaag gtacaagcga gacctggttc agaaactaaa aattttgcgg     1140

caagaacttt cccaacaaca gcctcaggca ggtcattgcc gcattgaggt ttccagggaa     1200

gagatttttg aggaatcata tcgacaggtc atgaaaatga gaccaaaaga tctctggaag     1260

cgattaatga taaaatttcg tggagaagaa ggccttgact atggaggcgt tgccagggaa     1320

tggttgtatc tcttgtcaca tgaaatgttg aatccatact atggcctctt ccagtattca     1380

agagatgata tttatacatt gcagatcaat cctgattctg cagttaatcc ggaacattta     1440

tcctatttcc actttgttgg acgaataatg ggaatggctg tgtttcatgg acattatatt     1500

gatggtggtt tcacattgcc tttttataag caattgcttg ggaagtcaat taccttggat     1560

gacatggagt tagtagatcc ggatcttcac aacagtttag tgtggatact tgagaatgat     1620

attacaggtg ttttggacca taccttctgt gttgaacata atgcatatgg tgaaattatt     1680

cagcatgaac ttaaaccaaa tggcaaaagt atccctgtta atgaagaaaa taaaaaagaa     1740

tatgtcaggc tctatgtgaa ctggagattt ttacgaggca ttgaggctca attcttggct     1800

ctgcagaaag gatttaatga agtaattcca caacatctgc tgaagacatt tgatgagaag     1860

gagttagagc tcattatttg tggacttgga aagatagatg ttaatgactg gaaggtaaac     1920

acccggttaa aacactgtac accagacagc aacattgtca aatggttctg gaaagctgtg     1980

gagttttttg atgaagagcg acgagcaaga ttgcttcagt ttgtgacagg atcctctcga     2040

gtgcctctgc agggcttcaa agcattgcaa ggtgctgcag gcccgagact ctttaccata     2100

caccagattg atgcctgcac taacaacctg ccgaaagccc acacttgctt caatcgaata     2160

gacattccac cctatgaaag ctatgaaaag ctatatgaaa agctgctaac agccattgaa     2220

gaaacatgtg gatttgctgt ggaatga                                         2247


<210>  29
<211>  2869
<212>  DNA
<213>  Homo sapiens

<400>  29
ggagtcgccg ccgccccgag ttccggtacc atgcatttca cggtggcctt gtggagacaa       60

cgccttaacc caaggaagtg actcaaactg tgagaactcc aggttttcca acctattggt      120

ggtatgtctg acagtggatc acaacttggt tcaatgggta gcctcaccat gaaatcacag      180

cttcagatca ctgtcatctc agcaaaactt aaggaaaata agaagaattg gtttggacca      240

agtccttacg tagaggtcac agtagatgga cagtcaaaga agacagaaaa atgcaacaac      300

acaaacagtc ccaagtggaa gcaacccctt acagttatcg ttacccctgt gagtaaatta      360

cattttcgtg tgtggagtca ccagacactg aaatctgatg ttttgttggg aactgctgca      420

ttagatattt atgaaacatt aaagtcaaac aatatgaaac ttgaagaagt agttgtgact      480

ttgcagcttg gaggtgacaa agagccaaca gagacaatag gagacttgtc aatttgtctt      540

gatgggctac agttagagtc tgaagttgtt accaatggtg aaactacatg ttcagaaagt      600

gcttctcaga atgatgatgg ctccagatcc aaggatgaaa caagagtgag cacaaatgga      660

tcagatgacc ctgaagatgc aggagctggt gaaaatagga gagtcagtgg gaataattct      720

ccatcactct caaatggtgg ttttaaacct tctagacctc caagaccttc acgaccacca      780

ccacccaccc cacgtagacc agcatctgtc aatggttcac catctgccac ttctgaaagt      840

gatgggtcta gtacaggctc tctgccgccg acaaatacaa atacaaatac atctgaagga      900

gcaacatctg gattaataat tcctcttact atatctggag gctcaggccc taggccatta      960

aatcctgtaa ctcaagctcc cttgccacct ggttgggagc agagagtgga ccagcacggg     1020

cgagtttact atgtagatca tgttgagaaa agaacaacat gggatagacc agaacctcta     1080

cctcctggct gggaacggcg ggttgacaac atgggacgta tttattatgt tgaccatttc     1140

acaagaacaa caacgtggca gaggccaaca ctggaatccg tccggaacta tgaacaatgg     1200

cagctacagc gtagtcagct tcaaggagca atgcagcagt ttaaccagag attcatttat     1260

gggaatcaag atttatttgc tacatcacaa agtaaagaat ttgatcctct tggtccattg     1320

ccacctggat gggagaagag aacagacagc aatggcagag tatatttcgt caaccacaac     1380

acacgaatta cacaatggga agaccccaga agtcaaggtc aattaaatga aaagccctta     1440

cctgaaggtt gggaaatgag attcacagtg gatggaattc catattttgt ggaccacaat     1500

agaagaacta ccacctatat agatccccgc acaggaaaat ctgccctaga caatggacct     1560

cagatagcct atgttcggga cttcaaagca aaggttcagt atttccggtt ctggtgtcag     1620

caactggcca tgccacagca cataaagatt acagtgacaa gaaaaacatt gtttgaggat     1680

tcctttcaac agataatgag cttcagtccc caagatctgc gaagacgttt gtgggtgatt     1740

tttccaggag aagaaggttt agattatgga ggtgtagcaa gagaatggtt ctttcttttg     1800

tcacatgaag tgttgaaccc aatgtattgc ctgtttgaat atgcagggaa ggataactac     1860

tgcttgcaga taaaccccgc ttcttacatc aatccagatc acctgaaata ttttcgtttt     1920

attggcagat ttattgccat ggctctgttc catgggaaat tcatagacac gggtttttct     1980

ttaccattct ataagcgtat cttgaacaaa ccagttggac tcaaggattt agaatctatt     2040

gatccagaat tttacaattc tctcatctgg gttaaggaaa acaatattga ggaatgtgat     2100

ttggaaatgt acttctccgt tgacaaagaa attctaggtg aaattaagag tcatgatctg     2160

aaacctaatg gtggcaatat tcttgtaaca gaagaaaata aagaggaata catcagaatg     2220

gtagctgagt ggaggttgtc tcgaggtgtt gaagaacaga cacaagcttt ctttgaaggc     2280

tttaatgaaa ttcttcccca gcaatatttg caatactttg atgcaaagga attagaggtc     2340

cttttatgtg gaatgcaaga gattgatttg aatgactggc aaagacatgc catctaccgt     2400

cattatgcaa ggaccagcaa acaaatcatg tggttttggc agtttgttaa agaaattgat     2460

aatgagaaga gaatgagact tctgcagttt gttactggaa cctgccgatt gccagtagga     2520

ggatttgctg atctcatggg gagcaatgga ccacagaaat tctgcattga aaaagttggg     2580

aaagaaaatt ggctacccag aagtcatacc tgttttaatc gcctggacct gccaccatac     2640

aagagctatg agcaactgaa ggaaaagctg ttgtttgcca tagaagaaac agaaggattt     2700

ggacaagagt aacttctgag aacttgcacc atgaatgggc aagaacttat ttgcaatgtt     2760

tgtccttctc tgcctgttgc acatcttgta aaattggaca atggctcttt agagagttat     2820

ctgagtgtaa gtaaattaat gttctcattt aaaaaaaaaa aaaaaaaaa                 2869


<210>  30
<211>  5169
<212>  DNA
<213>  Homo sapiens

<400>  30
gcgcatcagg cgctgttgtt ggagccggaa caccgtgcga ctctgaccga accggccccc       60

tcctcgcgca cacactcgcc gagccgcgcg cgcccctccg ccgtgacagt ggccgtggcc      120

tccgctctct cggggcaccc ggcagccaga gcgcagcgag agcgggcggt cgccagggtc      180

ccctccccag ccagtcccag gcgcccggtg cactatgcgg ggcacgtgcg ccccccagct      240

ctaatctgcg cgctgacagg agcatgatct gtgcccaggc cagggctgcc aaggaattga      300

tgcgcgtaca cgtggtgggt cattatgctg ctacacctgt gtagtgtgaa gaatctgtac      360

cagaacaggt ttttaggcct ggccgccatg gcgtctcctt ctagaaactc ccagagccga      420

cgccggtgca aggagccgct ccgatacagc tacaaccccg accagttcca caacatggac      480

ctcaggggcg gcccccacga tggcgtcacc attccccgct ccaccagcga cactgacctg      540

gtcacctcgg acagccgctc cacgctcatg gtcagcagct cctactattc catcgggcac      600

tctcaggacc tggtcatcca ctgggacata aaggaggaag tggacgctgg ggactggatt      660

ggcatgtacc tcattgatga ggtcttgtcc gaaaactttc tggactataa aaaccgtgga      720

gtcaatggtt ctcatcgggg ccagatcatc tggaagatcg atgccagctc gtactttgtg      780

gaacctgaaa ctaagatctg cttcaaatac taccatggag tgagtggggc cctgcgagca      840

accaccccca gtgtcacggt caaaaactcg gcagctccta tttttaaaag cattggtgct      900

gatgagaccg tccaaggaca aggaagtcgg aggctgatca gcttctctct ctcagatttc      960

caagccatgg ggttgaagaa agggatgttt ttcaacccag acccttatct gaagatttcc     1020

attcagcctg ggaaacacag catcttcccc gccctccctc accatggaca ggagaggaga     1080

tccaagatca taggcaacac cgtgaacccc atctggcagg ccgagcaatt cagttttgtg     1140

tccttgccca ctgacgtgct ggaaattgag gtgaaggaca agtttgccaa gagccgcccc     1200

atcatcaagc gcttcttggg aaagctgtcg atgcccgttc aaagactcct ggagagacac     1260

gccatagggg atagggtggt cagctacaca cttggccgca ggcttccaac agatcatgtg     1320

agtggacagc tgcaattccg atttgagatc acttcctcca tccacccaga tgatgaggag     1380

atttccctga gtaccgagcc tgagtcagcc caaattcagg acagccccat gaacaacctg     1440

atggaaagcg gcagtgggga acctcggtct gaggcaccag agtcctctga gagctggaag     1500

ccagagcagc tgggtgaggg cagtgtcccc gatggtccag ggaaccaaag catagagctt     1560

tccagaccag ctgaggaagc agcagtcatc acggaggcag gagaccaggg catggtctct     1620

gtgggacctg aaggggctgg ggagctcctg gcccaggtgc aaaaggacat ccagcctgcc     1680

cccagtgcag aagagctggc cgagcagctg gacctgggtg aggaggcatc agcactgctg     1740

ctggaagacg gtgaagcccc agccagcacc aaggaggagc ccttggagga ggaagcaacg     1800

acccagagcc gggctggaag ggaagaagag gagaaggagc aggaggagga gggagatgtg     1860

tctaccctgg agcagggaga gggcaggctg cagctgcggg cctcggtgaa gagaaaaagc     1920

aggccctgct ccttgcctgt gtccgagctg gagacggtga tcgcgtcagc ctgcggggac     1980

cccgagaccc cgcggacaca ctacatccgc atccacaccc tgctgcacag catgccctcc     2040

gcccagggcg gcagcgcggc agaggaggag gacggcgcgg aggaggagtc caccctcaag     2100

gactcctcgg agaaggatgg gctcagcgag gtggacacgg tggccgctga cccgtctgcc     2160

ctggaagagg acagagaaga gcccgagggg gctactccag gcacggcgca ccctggccac     2220

tccgggggcc acttccccag cctggccaat ggcgcggccc aggatggcga cacgcacccc     2280

agcaccggga gcgagagcga ctccagcccc aggcaaggcg gggaccacag ttgcgagggc     2340

tgtgacgcgt cctgctgcag cccctcgtgc tacagctcct cgtgctacag cacgtcctgc     2400

tacagcagct cgtgctacag cgcctcgtgc tacagcccct cctgctacaa cggcaacagg     2460

ttcgccagcc acacgcgctt ctcctccgtg gacagcgcca agatctccga gagcacggtc     2520

ttctcctcgc aagacgacga ggaggaggag aacagcgcgt tcgagtcggt acccgactcc     2580

atgcagagcc ctgagctgga cccggagtcc acgaacggcg ctgggccgtg gcaagacgag     2640

ctggccgccc ctagcgggca cgtggaaaga agcccggaag gtctggaatc ccccgtggca     2700

ggtccaagca atcggagaga agactgggaa gctcgaattg acagccacgg gcgggtcttt     2760

tatgtggacc acgtgaaccg cacaaccacc tggcagcgtc cgacggcagc agccaccccg     2820

gatggcatgc ggagatcggg gtccatccag cagatggagc aactcaacag gcggtatcaa     2880

aacattcagc gaaccattgc aacagagagg tccgaagaag attctggcag ccaaagctgc     2940

gagcaagccc cagcaggagg aggcggaggt ggagggagtg actcagaagc cgaatcttcc     3000

cagtccagct tagatctaag gagagagggg tcactttctc cagtgaactc acaaaaaatc     3060

accttgctgc tgcagtcccc agcggtcaag ttcatcacca accccgagtt cttcactgtg     3120

ctacacgcca attatagtgc ctaccgagtc ttcaccagta gcacctgctt aaagcacatg     3180

attctgaaag tccgacggga tgctcgcaat tttgaacgct accagcacaa ccgggacttg     3240

gtgaatttca tcaacatgtt cgcagacact cggctggaac tgccccgggg ctgggagatc     3300

aaaacggacc agcagggaaa gtcttttttc gtggaccaca acagtcgagc taccactttc     3360

attgaccccc gaatccctct tcagaacggt cgtcttccca atcatctaac tcaccgacag     3420

cacctccaga ggctccgaag ttacagcgcc ggagaggcct cagaagtttc tagaaacaga     3480

ggagcctctt tactggccag gccaggacac agcttagtag ctgctattcg aagccaacat     3540

caacatgagt cattgccact ggcatataat gacaagattg tggcatttct tcgccagcca     3600

aacatttttg aaatgctgca agagcgtcag ccaagcttag caagaaacca cacactcagg     3660

gagaaaatcc attacattcg gactgagggt aatcacgggc ttgagaagtt gtcctgtgat     3720

gcggatctgg tcattttgct gagtctcttt gaagaagaga ttatgtccta cgtccccctg     3780

caggctgcct tccaccctgg gtatagcttc tctccccgat gttcaccctg ttcttcacct     3840

cagaactccc caggtttaca gagagccagt gcaagagccc cttcccccta ccgaagagac     3900

tttgaggcca agctccgcaa tttctacaga aaactggaag ccaaaggatt tggtcagggt     3960

ccggggaaaa ttaagctcat tattcgccgg gatcatttgt tggagggaac cttcaatcag     4020

gtgatggcct attcgcggaa agagctccag cgaaacaagc tctacgtcac ctttgttgga     4080

gaggagggcc tggactacag tggcccctcg cgggagttct tcttccttct gtctcaggag     4140

ctcttcaacc cttactatgg actctttgag tactcggcaa atgatactta cacggtgcag     4200

atcagcccca tgtccgcatt tgtagaaaac catcttgagt ggttcaggtt tagcggtcgc     4260

atcctgggtc tggctctgat ccatcagtac cttcttgacg ctttcttcac gaggcccttc     4320

tacaaggcac tcctgagact gccctgtgat ttgagtgacc tggaatattt ggatgaggaa     4380

ttccaccaga gtttgcagtg gatgaaggac aacaacatca cagacatctt agacctcact     4440

ttcactgtta atgaagaggt ttttggacag gtcacggaaa gggagttgaa gtctggagga     4500

gccaacacac aggtgacgga gaaaaacaag aaggagtaca tcgagcgcat ggtgaagtgg     4560

cgggtggagc gcggcgtggt acagcagacc gaggcgctgg tgcgcggctt ctacgaggtt     4620

gtagactcga ggctggtgtc cgtgtttgat gccagggagc tggagctggt gatagctggc     4680

accgcggaaa tcgacctaaa tgactggcgg aataacactg agtaccgggg aggttaccac     4740

gatgggcatc ttgtgatccg ctggttctgg gctgcggtgg agcgcttcaa taatgagcag     4800

aggctgagat tactgcagtt tgtcacggga acatccagcg tgccctacga aggcttcgca     4860

gccctccgtg ggagcaatgg gcttcggcgc ttctgcatag agaaatgggg gaaaattact     4920

tctctcccca gggcacacac atgcttcaac cgactggatc ttccaccgta tccctcgtac     4980

tccatgttgt atgaaaagct gttaacagca gtagaggaaa ccagcacctt tggacttgag     5040

tgaggacatg gaacctcgcc tgacattttc ctggccagtg acatcaccct tcctgggatg     5100

atcccctttt ccctttccct taatcaactc tcctttgatt ttggtattcc atgattttta     5160

ttttcaaac                                                             5169


<210>  31
<211>  2715
<212>  DNA
<213>  Homo sapiens

<400>  31
agagttccat cagagcctgc agtggatgaa agacaatgat atccatgaca tcctagacct       60

cacgttcact gtgaacgaag aagtatttgg gcagataact gaacgagaat taaagccagg      120

gggtgccaat atcccagtta cagagaagaa caagaaggag tacatcgaga ggatggtgaa      180

gtggaggatt gagaggggtg ttgtacagca aacagagagc ttagtgcgtg gcttctatga      240

ggtggtggat gccaggctgg tatctgtttt tgatgcaaga gaactggaat tggtcatcgc      300

aggcacagct gaaatagacc taagtgattg gagaaacaac acagaatata gaggaggata      360

ccatgacaat catattgtaa ttcggtggtt ctgggctgca gtggaaagat tcaacaatga      420

acaacgacta aggttgttac agtttgttac aggcacatcc agcattccct atgaaggatt      480

tgcttcactc cgagggagta acggcccaag aagattctgt gtggagaaat gggggaaaat      540

cactgctctt cccagagcgc atacatgttt taaccgtctg gatctgcctc cctacccatc      600

cttttccatg ctttatgaaa aactgttgac agcagttgaa gaaaccagta cttttggact      660

tgagtgacct ggaagctgaa tgcccatctc tgtggacagg cagtttcaga agctgccttc      720

tagaagaatg attgaacatt ggaagtttca agaggatgct tcctttagga taaagctacg      780

tgctgttgtt ttccaggaac aagtgctctg tcacatttgg ggactggaga tgagtcctct      840

tggaaggatt tgggtgagct tgatgcccag ggaacaaccc aaccgtcttt caatcaacag      900

ttcttgactg ccaaactttt tccatttgtt atgttccaag acaaagatga acccatacat      960

gatcagctcc acggtaattt ttagggactc aggagaatct tgaaacttac ccttgaacgt     1020

ggttcaagcc aaactggcag catttggccc aatctccaaa ttagagcaag ttaaataata     1080

taataaaagt aaatatattt cctgaaagta cattcattta agccctaagt tataacagaa     1140

tattcatttc ttgcttatga gtgcctgcat ggtgtgcacc ataggtttcc gctttcatgg     1200

gacatgagtg aaaatgaaac caagtcaata tgaggtacct ttacagattt gcaataagat     1260

ggtctgtgac aatgtatatg caagtggtat gtgtgtaatt atggctaaag acaaaccatt     1320

attcagtgaa ttactaatga cagattttat gctttataat gcatgaaaac aattttaaaa     1380

taactagcaa ttaatcacag catatcagga aaaagtacac agtgagttct gtttattttt     1440

tgtaggctca ttatgtttat gttctttaag atgtatataa gaacctactt atcatgctgt     1500

atgtatcact cattccattt tcatgttcca tgcatactcg ggcatcatgc taatatgtat     1560

ccttttaagc actctcaagg aaacaaaagg gccttttatt tttataaagg taaaaaaaat     1620

tccccaaata ttttgcactg aatgtaccaa aggtgaaggg acattacaat atgactaaca     1680

gcaactccat cacttgagaa gtataataga aaatagcttc taaatcaaac ttccttcaca     1740

gtgccgtgtc taccactaca aggactgtgc atctaagtaa taatttttta agattcacta     1800

tatgtgatag tatgatatgc atttatttaa aatgcattag actctcttcc atccatcaaa     1860

tactttacag gatggcattt aatacagata tttcgtattt cccccactgc tttttatttg     1920

tacagcatca ttaaacacta agctcagtta aggagccatc agcaacactg aagagatcag     1980

tagtaagaat tccattttcc ctcatcagtg aagacaccac aaattgaaac tcagaactat     2040

atttctaagc ctgcattttc actgatgcat aattttctta ttaatattaa gagacagttt     2100

ttctatggca tctccaaaac tgcatgacat cactagtctt acttctgctt aattttatga     2160

gaaggtattc ttcattttaa ttgcttttgg gattactcca catctttgtt tatttcttga     2220

ctaatcagat tttcaataga gtgaagttaa attgggggtc ataaaagcat tggattgaca     2280

tatggtttgc cagcctatgg gtttacaggc attgcccaaa catttctttg agatctatat     2340

ttataagcag ccatggaatt cctattatgg gatgttggca atcttacatt ttatagaggt     2400

catatgcata gttttcatag gtgttttgta agaactgatt gctctcctgt gagttaagct     2460

atgtttacta ctgggaccct caagaggaat accacttatg ttacactcct gcactaaagg     2520

cacgtactgc agtgtgaaga aatgttctga aaaagggtta tagaaatctg gaaataagaa     2580

aggaagagct ctctgtattc tataattgga agagaaaaaa agaaaaactt ttaactggaa     2640

atgttagttt gtacttattg atcatgaata caagtatata tttaattttg caaaaaaaaa     2700

aaaaaaaaaa aaaag                                                      2715


<210>  32
<211>  195
<212>  DNA
<213>  Homo sapiens

<400>  32
cccttgccac ctggttggga gcagagagtg gaccagcacg ggcgagttta ctatgtagat       60

catgttgaga aaagaacaac atgggataga ccagaacctc tacctcctgg ctgggaacgg      120

cgggttgaca acatgggacg tatttattat gttgaccatt tcacaagaac aacaacgtgg      180

cagaggccaa cactg                                                       195


<210>  33
<211>  555
<212>  DNA
<213>  Homo sapiens

<400>  33
cccttgccac ctggttggga gcagagagtg gaccagcacg ggcgagttta ctatgtagat       60

catgttgaga aaagaacaac atgggataga ccagaacctc tacctcctgg ctgggaacgg      120

cgggttgaca acatgggacg tatttattat gttgaccatt tcacaagaac aacaacgtgg      180

cagaggccaa cactggaatc cgtccggaac tatgaacaat ggcagctaca gcgtagtcag      240

cttcaaggag caatgcagca gtttaaccag agattcattt atgggaatca agatttattt      300

gctacatcac aaagtaaaga atttgatcct cttggtccat tgccacctgg atgggagaag      360

agaacagaca gcaatggcag agtatatttc gtcaaccaca acacacgaat tacacaatgg      420

gaagacccca gaagtcaagg tcaattaaat gaaaagccct tacctgaagg ttgggaaatg      480

agattcacag tggatggaat tccatatttt gtggaccaca atagaagaac taccacctat      540

atagatcccc gcaca                                                       555


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Ala Leu Ala Leu Ala 
1               5   


<210>  35
<211>  238
<212>  PRT
<213>  Aequorea victoria

<400>  35

Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val 
1               5                   10                  15      


Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu 
            20                  25                  30          


Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys 
        35                  40                  45              


Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe 
    50                  55                  60                  


Ser Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln 
65                  70                  75                  80  


His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg 
                85                  90                  95      


Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val 
            100                 105                 110         


Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile 
        115                 120                 125             


Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn 
    130                 135                 140                 


Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly 
145                 150                 155                 160 


Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val 
                165                 170                 175     


Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro 
            180                 185                 190         


Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser 
        195                 200                 205             


Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val 
    210                 215                 220                 


Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210>  36
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  36

Glu Thr Leu Pro Ser Gly Trp Glu Gln Arg Lys Asp Pro His Gly Arg 
1               5                   10                  15      


Thr Tyr Tyr Val Asp His Asn Thr Arg Thr Thr Thr Trp Glu Arg Pro 
            20                  25                  30          


Gln Pro 
        


<210>  37
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  37

Gln Pro Leu Pro Pro Gly Trp Glu Arg Arg Val Asp Asp Arg Arg Arg 
1               5                   10                  15      


Val Tyr Tyr Val Asp His Asn Thr Arg Thr Thr Thr Trp Gln Arg Pro 
            20                  25                  30          


Thr Met 
        


<210>  38
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  38

Glu Asn Asp Pro Tyr Gly Pro Leu Pro Pro Gly Trp Glu Lys Arg Val 
1               5                   10                  15      


Asp Ser Thr Asp Arg Val Tyr Phe Val Asn His Asn Thr Lys Thr Thr 
            20                  25                  30          


Gln Trp Glu Asp Pro Arg Thr 
        35                  


<210>  39
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  39

Glu Pro Leu Pro Glu Gly Trp Glu Ile Arg Tyr Thr Arg Glu Gly Val 
1               5                   10                  15      


Arg Tyr Phe Val Asp His Asn Thr Arg Thr Thr Thr Phe Lys Asp Pro 
            20                  25                  30          


Arg Asn 
        


<210>  40
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Ala Leu Pro Ala Gly Trp Glu Gln Arg Glu Leu Pro Asn Gly Arg 
1               5                   10                  15      


Val Tyr Tyr Val Asp His Asn Thr Lys Thr Thr Thr Trp Glu Arg Pro 
            20                  25                  30          


Leu Pro 
        


<210>  41
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  41

Pro Leu Pro Pro Gly Trp Glu Lys Arg Thr Asp Pro Arg Gly Arg Phe 
1               5                   10                  15      


Tyr Tyr Val Asp His Asn Thr Arg Thr Thr Thr Trp Gln Arg Pro Thr 
            20                  25                  30          


Ala 
    


<210>  42
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  42

His Asp Pro Leu Gly Pro Leu Pro Pro Gly Trp Glu Lys Arg Gln Asp 
1               5                   10                  15      


Asn Gly Arg Val Tyr Tyr Val Asn His Asn Thr Arg Thr Thr Gln Trp 
            20                  25                  30          


Glu Asp Pro Arg Thr 
        35          


<210>  43
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  43

Pro Ala Leu Pro Pro Gly Trp Glu Met Lys Tyr Thr Ser Glu Gly Val 
1               5                   10                  15      


Arg Tyr Phe Val Asp His Asn Thr Arg Thr Thr Thr Phe Lys Asp Pro 
            20                  25                  30          


Arg Pro 
        


<210>  44
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  44

Ser Pro Leu Pro Pro Gly Trp Glu Glu Arg Gln Asp Ile Leu Gly Arg 
1               5                   10                  15      


Thr Tyr Tyr Val Asn His Glu Ser Arg Arg Thr Gln Trp Lys Arg Pro 
            20                  25                  30          


Thr Pro 
        


<210>  45
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  45

Ser Gly Leu Pro Pro Gly Trp Glu Glu Lys Gln Asp Glu Arg Gly Arg 
1               5                   10                  15      


Ser Tyr Tyr Val Asp His Asn Ser Arg Thr Thr Thr Trp Thr Lys Pro 
            20                  25                  30          


Thr Val 
        


<210>  46
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Phe Leu Pro Lys Gly Trp Glu Val Arg His Ala Pro Asn Gly Arg 
1               5                   10                  15      


Pro Phe Phe Ile Asp His Asn Thr Lys Thr Thr Thr Trp Glu Asp Pro 
            20                  25                  30          


Arg Leu 
        


<210>  47
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  47

Gly Pro Leu Pro Pro Gly Trp Glu Glu Arg Thr His Thr Asp Gly Arg 
1               5                   10                  15      


Ile Phe Tyr Ile Asn His Asn Ile Lys Arg Thr Gln Trp Glu Asp Pro 
            20                  25                  30          


Arg Leu 
        


<210>  48
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  48

Pro Glu Leu Pro Glu Gly Tyr Glu Gln Arg Thr Thr Val Gln Gly Gln 
1               5                   10                  15      


Val Tyr Phe Leu His Thr Gln Thr Gly Val Ser Thr Trp His Asp Pro 
            20                  25                  30          


Arg Ile 
        


<210>  49
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  49

Gly Pro Leu Pro Pro Gly Trp Glu Val Arg Ser Thr Val Ser Gly Arg 
1               5                   10                  15      


Ile Tyr Phe Val Asp His Asn Asn Arg Thr Thr Gln Phe Thr Asp Pro 
            20                  25                  30          


Arg Leu 
        


<210>  50
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  50

Asn Asp Leu Pro Asp Gly Trp Glu Glu Arg Arg Thr Ala Ser Gly Arg 
1               5                   10                  15      


Ile Gln Tyr Leu Asn His Ile Thr Arg Thr Thr Gln Trp Glu Arg Pro 
            20                  25                  30          


Thr Arg 
        


<210>  51
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  51

Pro Asp Leu Pro Glu Gly Tyr Glu Gln Arg Thr Thr Gln Gln Gly Gln 
1               5                   10                  15      


Val Tyr Phe Leu His Thr Gln Thr Gly Val Ser Thr Trp His Asp Pro 
            20                  25                  30          


Arg Val 
        


<210>  52
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  52

Gly Pro Leu Pro Pro Gly Trp Glu Ile Arg Asn Thr Ala Thr Gly Arg 
1               5                   10                  15      


Val Tyr Phe Val Asp His Asn Asn Arg Thr Thr Gln Phe Thr Asp Pro 
            20                  25                  30          


Arg Leu 
        


<210>  53
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  53

Ala Pro Leu Pro Pro Gly Trp Glu Gln Arg Val Asp Gln His Gly Arg 
1               5                   10                  15      


Val Tyr Tyr Val Asp His Val Glu Lys Arg Thr Thr Trp Asp Arg Pro 
            20                  25                  30          


Glu Pro 
        


<210>  54
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  54

Glu Pro Leu Pro Pro Gly Trp Glu Arg Arg Val Asp Asn Met Gly Arg 
1               5                   10                  15      


Ile Tyr Tyr Val Asp His Phe Thr Arg Thr Thr Thr Trp Gln Arg Pro 
            20                  25                  30          


Thr Leu 
        


<210>  55
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  55

Gly Pro Leu Pro Pro Gly Trp Glu Lys Arg Thr Asp Ser Asn Gly Arg 
1               5                   10                  15      


Val Tyr Phe Val Asn His Asn Thr Arg Ile Thr Gln Trp Glu Asp Pro 
            20                  25                  30          


Arg Ser 
        


<210>  56
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  56

Lys Pro Leu Pro Glu Gly Trp Glu Met Arg Phe Thr Val Asp Gly Ile 
1               5                   10                  15      


Pro Tyr Phe Val Asp His Asn Arg Arg Thr Thr Thr Tyr Ile Asp Pro 
            20                  25                  30          


Arg Thr 
        


<210>  57
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  57

Pro Leu Pro Pro Asn Trp Glu Ala Arg Ile Asp Ser His Gly Arg Val 
1               5                   10                  15      


Phe Tyr Val Asp His Val Asn Arg Thr Thr Thr Trp Gln Arg Pro Thr 
            20                  25                  30          


Ala 
    


<210>  58
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  58

Leu Glu Leu Pro Arg Gly Trp Glu Ile Lys Thr Asp Gln Gln Gly Lys 
1               5                   10                  15      


Ser Phe Phe Val Asp His Asn Ser Arg Ala Thr Thr Phe Ile Asp Pro 
            20                  25                  30          


Arg Ile 
        


<210>  59
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  59

Glu Ala Leu Pro Pro Asn Trp Glu Ala Arg Ile Asp Ser His Gly Arg 
1               5                   10                  15      


Ile Phe Tyr Val Asp His Val Asn Arg Thr Thr Thr Trp Gln Arg Pro 
            20                  25                  30          


Thr Ala 
        


<210>  60
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  60

Leu Glu Leu Pro Arg Gly Trp Glu Met Lys His Asp His Gln Gly Lys 
1               5                   10                  15      


Ala Phe Phe Val Asp His Asn Ser Arg Thr Thr Thr Phe Ile Asp Pro 
            20                  25                  30          


Arg Leu 
        


<210>  61
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  61

Gly Trp Glu Glu Lys Val Asp Asn Leu Gly Arg Thr Tyr Tyr Val Asn 
1               5                   10                  15      


His Asn Asn Arg Thr Thr Gln Trp His Arg Pro 
            20                  25          


<210>  62
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  62

Pro Ser Gly Trp Glu Glu Arg Lys Asp Ala Lys Gly Arg Thr Tyr Tyr 
1               5                   10                  15      


Val Asn His Asn Asn Arg Thr Thr Thr Trp Thr Arg Pro 
            20                  25                  


<210>  63
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  63

Pro Pro Gly Trp Glu Met Arg Ile Ala Pro Asn Gly Arg Pro Phe Phe 
1               5                   10                  15      


Ile Asp His Asn Thr Lys Thr Thr Thr Trp Glu Asp Pro Arg Leu 
            20                  25                  30      


<210>  64
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  64

Pro Pro Gly Trp Glu Glu Arg Ile His Leu Asp Gly Arg Thr Phe Tyr 
1               5                   10                  15      


Ile Asp His Asn Ser Lys Ile Thr Gln Trp Glu Asp Pro Arg Leu 
            20                  25                  30      


<210>  65
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  65

Met Glu Pro Val Asp Pro Arg Leu Glu Pro Trp Lys His Pro Gly Ser 
1               5                   10                  15      


Gln Pro Arg Thr Pro Cys Thr Thr Cys Tyr Cys Lys Lys Cys Cys Phe 
            20                  25                  30          


His Cys Gln Val Cys Phe Thr Thr Lys Ala Leu Gly Ile Ser Tyr Gly 
        35                  40                  45              


Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Gly Ser Gln Thr 
    50                  55                  60                  


His Gln Val Ser Leu Ser Lys Gln Pro Ser Ser Gln Pro Arg Gly Asp 
65                  70                  75                  80  


Gln Thr Gly Pro Lys Glu Ser Lys Lys Lys Val Glu Arg Glu Thr Glu 
                85                  90                  95      


Ala Asp Pro Lys Pro 
            100     


<210>  66
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  66

Met Glu Pro Val Asp Pro Arg Leu Glu Pro Trp Lys His Pro Gly Ser 
1               5                   10                  15      


Gln Pro Arg Thr Pro Cys Thr Thr Cys Tyr Cys Lys Lys Cys Cys Phe 
            20                  25                  30          


His Cys Gln Val Cys Phe Thr Thr Lys Ala Leu Gly Ile Ser Tyr Gly 
        35                  40                  45              


Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Gly Ser Gln Thr 
    50                  55                  60                  


His Gln Val Ser Leu Ser Lys Gln Pro Ser Ser Gln Pro Arg Gly Asp 
65                  70                  75                  80  


Gln Thr Gly Pro Lys Glu 
                85      


<210>  67
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  67

Cys Phe Thr Thr Lys Ala Leu Gly Ile Ser Tyr Gly Arg Lys Lys Arg 
1               5                   10                  15      


Arg Gln Arg Arg Arg Pro Pro Gln Gly Ser Gln Thr His Gln Val Ser 
            20                  25                  30          


Leu Ser Lys Gln 
        35      


<210>  68
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  68

Met Glu Pro Val Asp Pro Arg Leu Glu Pro Trp Lys His Pro Gly Ser 
1               5                   10                  15      


Gln Pro Arg Thr Pro Cys Thr Thr Cys Tyr Cys Lys Lys Cys Cys Phe 
            20                  25                  30          


His Cys Gln Val Cys Phe Thr Thr Lys Ala Leu Gly Ile 
        35                  40                  45  


<210>  69
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  69

Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Gly Ser Gln Thr 
1               5                   10                  15      


His Gln Val Ser Leu Ser Lys Gln Pro Ser Ser Gln Pro Arg Gly Asp 
            20                  25                  30          


Gln Thr Gly Pro Lys Glu 
        35              


<210>  70
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  70

Arg Arg Gln Arg Arg Arg Pro Pro Gln Gly Ser Gln Thr His Gln Val 
1               5                   10                  15      


Ser Leu Ser Lys Gln Pro Ser Ser Gln Pro Arg Gly Asp Gln Thr Gly 
            20                  25                  30          


Pro Lys Glu 
        35  


<210>  71
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  71

Arg Arg Arg Pro Pro Gln Gly Ser Gln Thr His Gln Val Ser Leu Ser 
1               5                   10                  15      


Lys Gln Pro Ser Ser Gln Pro Arg Gly Asp Gln Thr Gly Pro Lys Glu 
            20                  25                  30          


<210>  72
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  72

Pro Pro Gln Gly Ser Gln Thr His Gln Val Ser Leu Ser Lys Gln Pro 
1               5                   10                  15      


Ser Ser Gln Pro Arg Gly Asp Gln Thr Gly Pro Lys Glu 
            20                  25                  


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  73

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  74
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  74

Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro 
1               5                   10      


<210>  75
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  75

Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Gly 
1               5                   10              


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  76

Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Gly Ser Gln 
1               5                   10                  15  


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  77

Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Gly Ser Gln Thr 
1               5                   10                  15      


His 
    


<210>  78
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  78

Cys Phe Thr Thr Lys Ala Leu Gly Ile Ser Tyr Gly Arg Lys Lys Arg 
1               5                   10                  15      


Arg Gln Arg Arg Arg 
            20      


<210>  79
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  79

Cys Phe Thr Thr Lys Ala Leu Gly Ile Ser Tyr Gly Arg Lys Lys Arg 
1               5                   10                  15      


Arg Gln Arg Arg Arg Pro Pro Gln Gly Ser Gln 
            20                  25          


<210>  80
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  80

Gly Arg Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro 
1               5                   10          


<210>  81
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  81

Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Gly Ser Gln Thr 
1               5                   10                  15      


His 
    


<210>  82
<211>  130
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  82

Met Glu Thr Pro Leu Lys Ala Pro Glu Gly Ser Leu Gly Ser Tyr Asn 
1               5                   10                  15      


Glu Pro Ser Ser Cys Thr Ser Glu Gln Asp Ala Ala Ala Gln Gly Leu 
            20                  25                  30          


Val Ser Pro Gly Asp Glu Ile Leu Tyr Gln Leu Tyr Gln Pro Leu Glu 
        35                  40                  45              


Ala Cys Asp Asn Lys Cys Tyr Cys Lys Lys Cys Cys Tyr His Cys Gln 
    50                  55                  60                  


Met Cys Phe Leu Asn Lys Gly Leu Gly Ile Trp Tyr Glu Arg Lys Gly 
65                  70                  75                  80  


Arg Arg Arg Arg Thr Pro Lys Lys Thr Lys Ala His Ser Ser Ser Ala 
                85                  90                  95      


Ser Asp Lys Ser Ile Ser Thr Arg Thr Gly Asn Ser Gln Pro Glu Lys 
            100                 105                 110         


Lys Gln Lys Lys Thr Leu Glu Thr Ala Leu Glu Thr Ile Gly Gly Pro 
        115                 120                 125             


Gly Arg 
    130 


<210>  83
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  83

Met Pro Gly Pro Trp Val Ala Met Ile Met Leu Pro Gln Pro Lys Glu 
1               5                   10                  15      


Ser Phe Gly Gly Lys Pro Ile Gly Trp Leu Phe Trp Asn Thr Cys Lys 
            20                  25                  30          


Gly Pro Arg Arg Asp Cys Pro His Cys Cys Cys Pro Ile Cys Ser Trp 
        35                  40                  45              


His Cys Gln Leu Cys Phe Leu Gln Lys Asn Leu Gly Ile Asn Tyr Gly 
    50                  55                  60                  


Ser Gly Pro Arg Arg Arg Gly Thr Arg Gly Lys Gly Arg Arg Ile Arg 
65                  70                  75                  80  


Arg Thr Ala Ser Gly Gly Asp Gln Arg Arg Glu Ala Asp Ser Gln Arg 
                85                  90                  95      


Ser Phe Thr Asn Met Asp Gln 
            100             


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  84

Ser Gly Pro Arg Pro Arg Gly Thr Arg Gly Lys Gly Arg Arg Ile Arg 
1               5                   10                  15      


Arg 
    


<210>  85
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  85
gggcccggag accagacgag ccgggagccc ggcaacaggg aacccacg                    48


<210>  86
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  86
gggcccggag accagacgag ccgggccggc aacagggaac ccacg                       45


<210>  87
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  87
gggcccggag accagacgag ccgggagccc ggcaacaggg aacc                        44


<210>  88
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  88
agacgagccg ggagccc                                                      17


<210>  89
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  89
gccggagccg ggaagcccga gc                                                22


<210>  90
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  90
cggagccaag cccga                                                        15


<210>  91
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  91
ggcgggcgca gcgcaagcga cggacaggcc                                        30


<210>  92
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  92
ggcggaccga ccggacggag aaacagcc                                          28


<210>  93
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  93

Met Ala Gly Arg Ser Gly Asp Ser Asp Glu Glu Leu Ile Arg Thr Val 
1               5                   10                  15      


Arg Leu Ile Lys Leu Leu Tyr Gln Ser Asn Pro Pro Pro Asn Pro Glu 
            20                  25                  30          


Gly Thr Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu Arg 
        35                  40                  45              


Gln Arg Gln Ile His Ser Ile Ser Glu Arg Ile Leu Gly Thr Tyr Leu 
    50                  55                  60                  


Gly Arg Ser Ala Glu Pro Val Pro Leu Gln Leu Pro Pro Leu Glu Arg 
65                  70                  75                  80  


Leu Thr Leu Asp Cys Asn Glu Asp Cys Gly Thr Ser Gly Thr Gln Gly 
                85                  90                  95      


Val Gly Ser Pro Gln Ile Leu Val Glu Ser Pro Thr Val Leu Glu Ser 
            100                 105                 110         


Gly Thr Lys Glu 
        115     


<210>  94
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  94

Thr Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu Arg Gln 
1               5                   10                  15      


Arg 
    


<210>  95
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  95

Arg Asp Arg Arg Arg Arg Gly Ser Arg Pro Ser Gly Ala Glu Arg Arg 
1               5                   10                  15      


Arg Arg Arg Ala Ala Ala Ala 
            20              


<210>  96
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  96
acagaggaac ccag                                                         14


<210>  97
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  97
ccggaggaca ccacggg                                                      17


<210>  98
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  98
ccacagcacg gg                                                           12


<210>  99
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  99

Ala Ser Asn Phe Thr Gln Phe Val Leu Val Asp Asn Gly Gly Thr Gly 
1               5                   10                  15      


Asp Val Thr Val Ala Pro Ser Asn Phe Ala Asn Gly Val Ala Glu Trp 
            20                  25                  30          


Ile Ser Ser Asn Ser Arg Ser Gln Ala Tyr Lys Val Thr Cys Ser Val 
        35                  40                  45              


Arg Gln Ser Ser Ala Gln Asn Arg Lys Tyr Thr Ile Lys Val Glu Val 
    50                  55                  60                  


Pro Lys Val Ala Thr Gln Thr Val Gly Gly Val Glu Leu Pro Val Ala 
65                  70                  75                  80  


Ala Trp Arg Ser Tyr Leu Asn Met Glu Leu Thr Ile Pro Ile Phe Ala 
                85                  90                  95      


Thr Asn Ser Asp Cys Glu Leu Ile Val Lys Ala Met Gln Gly Leu Leu 
            100                 105                 110         


Lys Asp Gly Asn Pro Ile Pro Ser Ala Ile Ala Ala Asn Ser Gly Ile 
        115                 120                 125             


Tyr 
    


<210>  100
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  100

Asn Ala Lys Thr Arg Arg His Glu Arg Arg Arg Lys Leu Ala Ile Glu 
1               5                   10                  15      


Arg Asp Thr Ile 
            20  


<210>  101
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  101

Gly Ser Met Asp Ala Gln Thr Arg Arg Arg Glu Arg Arg Ala Glu Lys 
1               5                   10                  15      


Gln Ala Gln Trp Lys Ala Ala Asn 
            20                  


<210>  102
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  102

Gly Thr Ala Lys Ser Arg Tyr Lys Ala Arg Arg Ala Glu Leu Ile Ala 
1               5                   10                  15      


Glu Arg Arg 
            


<210>  103
<211>  55
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  103

Met Gln Lys Gly Asn Phe Arg Asn Gln Arg Lys Thr Val Lys Cys Phe 
1               5                   10                  15      


Asn Cys Gly Lys Glu Gly His Ile Ala Lys Asn Cys Arg Ala Pro Arg 
            20                  25                  30          


Lys Lys Gly Cys Trp Lys Cys Gly Lys Glu Gly His Gln Met Lys Asp 
        35                  40                  45              


Cys Thr Glu Arg Gln Ala Asn 
    50                  55  


<210>  104
<211>  15
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  104
gcgcugacaa agcgc                                                        15


<210>  105
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  105
gggcccugaa gaagggccc                                                    19


<210>  106
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  106
ucucaaccua accguugaga                                                   20


<210>  107
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  107
ggacuagcgg aggcuagucc                                                   20


<210>  108
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  108

Ser Gly Phe Ala Asn Glu Leu Gly Pro Arg Leu Met Gly His 
1               5                   10                  


<210>  109
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  109

Pro Pro Lys Lys Lys Arg Lys Val 
1               5               


<210>  110
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  110

Met Met Ser Phe Val Ser Leu Leu Leu Val Gly Ile Leu Phe Trp Ala 
1               5                   10                  15      


Thr Glu Ala Glu Gln Leu Thr Lys Cys Glu Val Phe Gln 
            20                  25                  


<210>  111
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  111

Lys Asp Glu Leu 
1               


<210>  112
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  112

Met Leu Ser Leu Arg Gln Ser Ile Arg Phe Phe Leu Pro Ala Thr Arg 
1               5                   10                  15      


Thr Leu Cys Ser Ser Arg Tyr Leu Leu 
            20                  25  


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  misc_feature
<222>  (3)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  113

Arg Leu Xaa Xaa Xaa Xaa Xaa His Leu 
1               5                   


<210>  114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  114

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  115
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  115

Met Asp Ser Leu Leu Met Asn Arg Arg Lys Phe Leu Tyr Gln Phe Lys 
1               5                   10                  15      


Asn Val Arg Trp Ala Lys Gly Arg Arg Glu Thr Tyr Leu Cys 
            20                  25                  30  


<210>  116
<211>  57
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  116
ccaagggauc aaucggucuc ucgagggucc gagucuagac cagauugguc ucucugg          57


