                         SEQUENCE LISTING

<110>  University of Florida Research Foundation
 
<120>  TARGETED EFFECTOR PROTEINS AND USES THEREOF

<130>  222109-2770

<150>  US 62/403872
<151>  2016-10-04

<150>  US 62/478880
<151>  2017-03-30

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A fustion protein as described herein

<400>  1

Met Ala Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln Thr 
1               5                   10                  15      


Ala Gly Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser 
            20                  25                  30          


Leu Phe Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile Val 
        35                  40                  45              


Leu Ser Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile Pro 
    50                  55                  60                  


Tyr Glu Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe 
65                  70                  75                  80  


Lys Val Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His 
                85                  90                  95      


Tyr Gly Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr 
            100                 105                 110         


Phe Gly Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile 
        115                 120                 125             


Thr Val Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg 
    130                 135                 140                 


Leu Ile Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly 
145                 150                 155                 160 


Val Thr Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala Gly Ser Gly Gly 
                165                 170                 175     


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Met Ala Arg Met Lys Gln 
            180                 185                 190         


Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys Asn Tyr His Leu Glu 
        195                 200                 205             


Asn Arg Val Ala Arg Leu Glu Lys Leu Val Gly Glu Arg Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly Glu Phe Ala 
225                 230                 235                 240 


Asp Asn Phe Ser Leu His Asp Ala Leu Ser Gly Ser Gly Asn Pro Asn 
                245                 250                 255     


Pro Gln Gly Trp Pro Gly Ala Trp Gly Asn Gln Pro Ala Gly Ala Gly 
            260                 265                 270         


Gly Tyr Pro Gly Ala Ser Tyr Pro Gly Ala Tyr Pro Gly Gln Ala Pro 
        275                 280                 285             


Pro Gly Ala Tyr Pro Gly Gln Ala Pro Pro Gly Ala Tyr Pro Gly Ala 
    290                 295                 300                 


Pro Gly Ala Tyr Pro Gly Ala Pro Ala Pro Gly Val Tyr Pro Gly Pro 
305                 310                 315                 320 


Pro Ser Gly Pro Gly Ala Tyr Pro Ser Ser Gly Gln Pro Ser Ala Pro 
                325                 330                 335     


Gly Ala Tyr Pro Ala Thr Gly Pro Tyr Gly Ala Pro Ala Gly Pro Leu 
            340                 345                 350         


Ile Val Pro Tyr Asn Leu Pro Leu Pro Gly Gly Val Val Pro Arg Met 
        355                 360                 365             


Leu Ile Thr Ile Leu Gly Thr Val Lys Pro Asn Ala Asn Arg Ile Ala 
    370                 375                 380                 


Leu Asp Phe Gln Arg Gly Asn Asp Val Ala Phe His Phe Asn Pro Arg 
385                 390                 395                 400 


Phe Asn Glu Asn Asn Arg Arg Val Ile Val Cys Asn Thr Lys Leu Asp 
                405                 410                 415     


Asn Asn Trp Gly Arg Glu Glu Arg Gln Ser Val Phe Pro Phe Glu Ser 
            420                 425                 430         


Gly Lys Pro Phe Lys Ile Gln Val Leu Val Glu Pro Asp His Phe Lys 
        435                 440                 445             


Val Ala Val Asn Asp Ala His Leu Leu Gln Tyr Asn His Arg Val Lys 
    450                 455                 460                 


Lys Leu Asn Glu Ile Ser Lys Leu Gly Ile Ser Gly Asp Ile Asp Leu 
465                 470                 475                 480 


Thr Ser Ala Ser Tyr Asn Met Ile Leu Glu His His His His His His 
                485                 490                 495     


<210>  2
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  An alpha-helix trimer domain (an alpha-helix coil).

<400>  2

Met Ala Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser 
1               5                   10                  15      


Lys Asn Tyr His Leu Glu Asn Arg Val Ala Arg Leu Glu Lys Leu Val 
            20                  25                  30          


Gly Glu Arg 
        35  


<210>  3
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  An alpha-helix trimer domain.


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Xaa Arg Met Lys Gln Leu Glu Asp Lys Val Glu Glu Leu Leu Ser Lys 
1               5                   10                  15      


Asn Tyr His Leu Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly 
            20                  25                  30          


Glu Arg 
        


<210>  4
<211>  757
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pentamer Alpha-helix domain (full sequence of 
       cartilage-oligomeric matrix protein, or fragments thereof):

<400>  4

Met Val Pro Asp Thr Ala Cys Val Leu Leu Leu Thr Leu Ala Ala Leu 
1               5                   10                  15      


Gly Ala Ser Gly Gln Gly Gln Ser Pro Leu Gly Ser Asp Leu Gly Pro 
            20                  25                  30          


Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala Leu Gln Asp Val 
        35                  40                  45              


Arg Asp Trp Leu Arg Gln Gln Val Arg Glu Ile Thr Phe Leu Lys Asn 
    50                  55                  60                  


Thr Val Met Glu Cys Asp Ala Cys Gly Met Gln Gln Ser Val Arg Thr 
65                  70                  75                  80  


Gly Leu Pro Ser Val Arg Pro Leu Leu His Cys Ala Pro Gly Phe Cys 
                85                  90                  95      


Phe Pro Gly Val Ala Cys Ile Gln Thr Glu Ser Gly Gly Arg Cys Gly 
            100                 105                 110         


Pro Cys Pro Ala Gly Phe Thr Gly Asn Gly Ser His Cys Thr Asp Val 
        115                 120                 125             


Asn Glu Cys Asn Ala His Pro Cys Phe Pro Arg Val Arg Cys Ile Asn 
    130                 135                 140                 


Thr Ser Pro Gly Phe Arg Cys Glu Ala Cys Pro Pro Gly Tyr Ser Gly 
145                 150                 155                 160 


Pro Thr His Gln Gly Val Gly Leu Ala Phe Ala Lys Ala Asn Lys Gln 
                165                 170                 175     


Val Cys Thr Asp Ile Asn Glu Cys Glu Thr Gly Gln His Asn Cys Val 
            180                 185                 190         


Pro Asn Ser Val Cys Ile Asn Thr Arg Gly Ser Phe Gln Cys Gly Pro 
        195                 200                 205             


Cys Gln Pro Gly Phe Val Gly Asp Gln Ala Ser Gly Cys Gln Arg Gly 
    210                 215                 220                 


Ala Gln Arg Phe Cys Pro Asp Gly Ser Pro Ser Glu Cys His Glu His 
225                 230                 235                 240 


Ala Asp Cys Val Leu Glu Arg Asp Gly Ser Arg Ser Cys Val Cys Arg 
                245                 250                 255     


Val Gly Trp Ala Gly Asn Gly Ile Leu Cys Gly Arg Asp Thr Asp Leu 
            260                 265                 270         


Asp Gly Phe Pro Asp Glu Lys Leu Arg Cys Pro Glu Pro Gln Cys Arg 
        275                 280                 285             


Lys Asp Asn Cys Val Thr Val Pro Asn Ser Gly Gln Glu Asp Val Asp 
    290                 295                 300                 


Arg Asp Gly Ile Gly Asp Ala Cys Asp Pro Asp Ala Asp Gly Asp Gly 
305                 310                 315                 320 


Val Pro Asn Glu Lys Asp Asn Cys Pro Leu Val Arg Asn Pro Asp Gln 
                325                 330                 335     


Arg Asn Thr Asp Glu Asp Lys Trp Gly Asp Ala Cys Asp Asn Cys Arg 
            340                 345                 350         


Ser Gln Lys Asn Asp Asp Gln Lys Asp Thr Asp Gln Asp Gly Arg Gly 
        355                 360                 365             


Asp Ala Cys Asp Asp Asp Ile Asp Gly Asp Arg Ile Arg Asn Gln Ala 
    370                 375                 380                 


Asp Asn Cys Pro Arg Val Pro Asn Ser Asp Gln Lys Asp Ser Asp Gly 
385                 390                 395                 400 


Asp Gly Ile Gly Asp Ala Cys Asp Asn Cys Pro Gln Lys Ser Asn Pro 
                405                 410                 415     


Asp Gln Ala Asp Val Asp His Asp Phe Val Gly Asp Ala Cys Asp Ser 
            420                 425                 430         


Asp Gln Asp Gln Asp Gly Asp Gly His Gln Asp Ser Arg Asp Asn Cys 
        435                 440                 445             


Pro Thr Val Pro Asn Ser Ala Gln Glu Asp Ser Asp His Asp Gly Gln 
    450                 455                 460                 


Gly Asp Ala Cys Asp Asp Asp Asp Asp Asn Asp Gly Val Pro Asp Ser 
465                 470                 475                 480 


Arg Asp Asn Cys Arg Leu Val Pro Asn Pro Gly Gln Glu Asp Ala Asp 
                485                 490                 495     


Arg Asp Gly Val Gly Asp Val Cys Gln Asp Asp Phe Asp Ala Asp Lys 
            500                 505                 510         


Val Val Asp Lys Ile Asp Val Cys Pro Glu Asn Ala Glu Val Thr Leu 
        515                 520                 525             


Thr Asp Phe Arg Ala Phe Gln Thr Val Val Leu Asp Pro Glu Gly Asp 
    530                 535                 540                 


Ala Gln Ile Asp Pro Asn Trp Val Val Leu Asn Gln Gly Arg Glu Ile 
545                 550                 555                 560 


Val Gln Thr Met Asn Ser Asp Pro Gly Leu Ala Val Gly Tyr Thr Ala 
                565                 570                 575     


Phe Asn Gly Val Asp Phe Glu Gly Thr Phe His Val Asn Thr Val Thr 
            580                 585                 590         


Asp Asp Asp Tyr Ala Gly Phe Ile Phe Gly Tyr Gln Asp Ser Ser Ser 
        595                 600                 605             


Phe Tyr Val Val Met Trp Lys Gln Met Glu Gln Thr Tyr Trp Gln Ala 
    610                 615                 620                 


Asn Pro Phe Arg Ala Val Ala Glu Pro Gly Ile Gln Leu Lys Ala Val 
625                 630                 635                 640 


Lys Ser Ser Thr Gly Pro Gly Glu Gln Leu Arg Asn Ala Leu Trp His 
                645                 650                 655     


Thr Gly Asp Thr Glu Ser Gln Val Arg Leu Leu Trp Lys Asp Pro Arg 
            660                 665                 670         


Asn Val Gly Trp Lys Asp Lys Lys Ser Tyr Arg Trp Phe Leu Gln His 
        675                 680                 685             


Arg Pro Gln Val Gly Tyr Ile Arg Val Arg Phe Tyr Glu Gly Pro Glu 
    690                 695                 700                 


Leu Val Ala Asp Ser Asn Val Val Leu Asp Thr Thr Met Arg Gly Gly 
705                 710                 715                 720 


Arg Leu Gly Val Phe Cys Phe Ser Gln Glu Asn Ile Ile Trp Ala Asn 
                725                 730                 735     


Leu Arg Tyr Arg Cys Asn Asp Thr Ile Pro Glu Asp Tyr Glu Thr His 
            740                 745                 750         


Gln Leu Arg Gln Ala 
        755         


<210>  5
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A tetramer Alpha-helix domain: GCN4-pVe/GCN4-pVg HETEROTETRAMER; 
       GCN4-pVe SEQUENCE

<400>  5

Met Lys Val Lys Gln Leu Val Asp Lys Val Glu Glu Leu Leu Ser Lys 
1               5                   10                  15      


Asn Tyr His Leu Val Asn Glu Val Ala Arg Leu Val Lys Leu Val Gly 
            20                  25                  30          


Glu Arg 
        


<210>  6
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tetramer Alpha-helix domains: GCN4-pVe/GCN4-pVg 
       HETEROTETRAMER:GCN4-pVg

<400>  6

Met Lys Val Lys Gln Leu Glu Asp Val Val Glu Glu Leu Leu Ser Val 
1               5                   10                  15      


Asn Tyr His Leu Glu Asn Val Val Ala Arg Leu Lys Lys Leu Val Gly 
            20                  25                  30          


Glu Arg 
        


<210>  7
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tetramer Alpha-helix domains:GCN4-pVe/GCN4-pVg HETEROTETRAMER: 
       GCN4-pAe SEQUENCE

<400>  7

Met Lys Val Lys Gln Leu Ala Asp Lys Val Glu Glu Leu Leu Ser Lys 
1               5                   10                  15      


Asn Tyr His Leu Ala Asn Glu Val Ala Arg Leu Ala Lys Leu Val Gly 
            20                  25                  30          


Glu Arg 
        


<210>  8
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tetramer Alpha-helix domains: GCN4-pVe/GCN4-pVg HETEROTETRAMER: 
       GCN4-pAg SEQUENCE

<400>  8

Met Lys Val Lys Gln Leu Glu Asp Ala Val Glu Glu Leu Leu Ser Ala 
1               5                   10                  15      


Asn Tyr His Leu Glu Asn Ala Val Ala Arg Leu Lys Lys Leu Val Gly 
            20                  25                  30          


Glu Arg 
        


<210>  9
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A heptamer Alpha-helix domain (CC-Hept)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  9

Xaa Gly Glu Ile Ala Gln Ala Leu Lys Glu Ile Ala Lys Ala Leu Lys 
1               5                   10                  15      


Glu Ile Ala Trp Ala Leu Lys Glu Ile Ala Gln Ala Leu Lys Gly 
            20                  25                  30      


<210>  10
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Heptamer Alpha-helix domain (CC-Hept-homoCys-H-E)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  10

Xaa Gly Glu Ile Ala Lys Ala Leu Arg Glu Ile Ala Lys Ala Leu Arg 
1               5                   10                  15      


Glu Xaa Ala Trp Ala His Arg Glu Glu Ala Lys Ala Leu Arg Gly 
            20                  25                  30      


<210>  11
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A heptamer Alpha-helix domain (CC-Hept-I18betaMeCys-L22H-I25E)


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  11

Xaa Gly Glu Ile Ala Lys Ala Leu Arg Glu Ile Ala Lys Ala Leu Arg 
1               5                   10                  15      


Glu Cys Ala Trp Ala His Arg Glu Glu Ala Lys Ala Leu Arg Gly 
            20                  25                  30      


<210>  12
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Heptamer Alpha-helix domain (CC-Hept-I18C-L22H-I25E )


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  12

Xaa Gly Glu Ile Ala Lys Ala Leu Arg Glu Ile Ala Lys Ala Leu Arg 
1               5                   10                  15      


Glu Cys Ala Trp Ala His Arg Glu Glu Ala Lys Ala Leu Arg Gly 
            20                  25                  30      


<210>  13
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Heptamer Alpha-helix domain (CC-Hept-I18C-L22H )


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  13

Xaa Gly Glu Ile Ala Lys Ala Leu Arg Glu Ile Ala Lys Ala Leu Arg 
1               5                   10                  15      


Glu Cys Ala Trp Ala His Arg Glu Ile Ala Lys Ala Leu Arg Gly 
            20                  25                  30      


<210>  14
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Heptamer Alpha-helix domain (CC-Hept-I-H-I )


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  14

Xaa Gly Glu Ile Ala Lys Ala Leu Arg Glu Ile Ala Lys Ala Leu Arg 
1               5                   10                  15      


Glu Ile Ala Trp Ala His Arg Glu Ile Ala Lys Ala Leu Arg Gly 
            20                  25                  30      


<210>  15
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Heptamer Alpha-helix domain (CC-Hept-I-C-I )


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Xaa Gly Glu Ile Ala Gln Ala Leu Lys Glu Ile Ala Lys Ala Leu Lys 
1               5                   10                  15      


Glu Ile Ala Trp Ala Cys Lys Glu Ile Ala Gln Ala Leu Lys Gly 
            20                  25                  30      


<210>  16
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A Heptamer Alpha-helix domain (GCN4-pAA SEQUENCE)

<400>  16

Met Lys Val Lys Gln Leu Ala Asp Ala Val Glu Glu Leu Ala Ser Ala 
1               5                   10                  15      


Asn Tyr His Leu Ala Asn Ala Val Ala Arg Leu Ala Lys Ala Val Gly 
            20                  25                  30          


Glu Arg 
        


<210>  17
<211>  170
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A nanoluciferase

<400>  17

Val Phe Thr Leu Glu Asp Phe Val Gly Asp Trp Arg Gln Thr Ala Gly 
1               5                   10                  15      


Tyr Asn Leu Asp Gln Val Leu Glu Gln Gly Gly Val Ser Ser Leu Phe 
            20                  25                  30          


Gln Asn Leu Gly Val Ser Val Thr Pro Ile Gln Arg Ile Val Leu Ser 
        35                  40                  45              


Gly Glu Asn Gly Leu Lys Ile Asp Ile His Val Ile Ile Pro Tyr Glu 
    50                  55                  60                  


Gly Leu Ser Gly Asp Gln Met Gly Gln Ile Glu Lys Ile Phe Lys Val 
65                  70                  75                  80  


Val Tyr Pro Val Asp Asp His His Phe Lys Val Ile Leu His Tyr Gly 
                85                  90                  95      


Thr Leu Val Ile Asp Gly Val Thr Pro Asn Met Ile Asp Tyr Phe Gly 
            100                 105                 110         


Arg Pro Tyr Glu Gly Ile Ala Val Phe Asp Gly Lys Lys Ile Thr Val 
        115                 120                 125             


Thr Gly Thr Leu Trp Asn Gly Asn Lys Ile Ile Asp Glu Arg Leu Ile 
    130                 135                 140                 


Asn Pro Asp Gly Ser Leu Leu Phe Arg Val Thr Ile Asn Gly Val Thr 
145                 150                 155                 160 


Gly Trp Arg Leu Cys Glu Arg Ile Leu Ala 
                165                 170 


<210>  18
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A linker

<400>  18

Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10                  


<210>  19
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A linker

<400>  19

Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


<210>  20
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CC1

<400>  20

Met Ala Arg Met Lys Gln Leu Lys Lys Lys Phe Glu Glu Leu Lys Ser 
1               5                   10                  15      


Lys Ala Gln Gln Leu Lys Lys Lys Ala Ala Gln Leu Lys Lys Lys Val 
            20                  25                  30          


Gly 
    


<210>  21
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CC2

<400>  21

Met Ala Arg Met Lys Gln Leu Glu Lys Lys Ala Glu Glu Leu Glu Ser 
1               5                   10                  15      


Lys Phe Gln Gln Leu Glu Lys Lys Ala Ala Gln Leu Glu Lys Lys Val 
            20                  25                  30          


Gly 
    


<210>  22
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CC3

<400>  22

Met Ala Arg Met Lys Gln Leu Glu Lys Glu Ala Glu Glu Leu Glu Ser 
1               5                   10                  15      


Glu Ala Gln Gln Leu Glu Lys Phe Ala Gln Leu Glu Lys Glu Val Gly 
            20                  25                  30          


<210>  23
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CC1-GFP

<400>  23

Met Ala Arg Met Lys Gln Leu Lys Lys Lys Phe Glu Glu Leu Lys Ser 
1               5                   10                  15      


Lys Ala Gln Gln Leu Lys Lys Lys Ala Ala Gln Leu Lys Lys Lys Val 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Ser Gly Glu Phe Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
    50                  55                  60                  


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
65                  70                  75                  80  


Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Ile Gly Lys Leu Thr Leu 
                85                  90                  95      


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
            100                 105                 110         


Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp 
        115                 120                 125             


His Met Lys Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
    130                 135                 140                 


Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Lys Tyr Lys Thr 
145                 150                 155                 160 


Arg Ala Val Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
                165                 170                 175     


Leu Lys Gly Thr Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
            180                 185                 190         


Leu Glu Tyr Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys 
        195                 200                 205             


Gln Lys Asn Gly Ile Lys Ala Asn Phe Thr Val Arg His Asn Val Glu 
    210                 215                 220                 


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
225                 230                 235                 240 


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
                245                 250                 255     


Thr Val Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
            260                 265                 270         


His Glu Tyr Val Asn Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
        275                 280                 285             


Tyr Lys Leu Glu His His His His His His 
    290                 295             


<210>  24
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CC2-GFP

<400>  24

Met Ala Arg Met Lys Gln Leu Glu Lys Lys Ala Glu Glu Leu Glu Ser 
1               5                   10                  15      


Lys Phe Gln Gln Leu Glu Lys Lys Ala Ala Gln Leu Glu Lys Lys Val 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Ser Met Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
    50                  55                  60                  


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Arg Gly 
65                  70                  75                  80  


Glu Gly Glu Gly Asp Ala Thr Asn Gly Lys Leu Thr Leu Lys Phe Ile 
                85                  90                  95      


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
            100                 105                 110         


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
        115                 120                 125             


Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
    130                 135                 140                 


Arg Thr Ile Ser Phe Lys Asp Asp Gly Thr Tyr Lys Thr Arg Ala Glu 
145                 150                 155                 160 


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
                165                 170                 175     


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
            180                 185                 190         


Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys Gln Lys Asn 
        195                 200                 205             


Gly Ile Lys Ala Asn Phe Lys Ile Arg His Asn Val Glu Asp Gly Ser 
    210                 215                 220                 


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
225                 230                 235                 240 


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Val Leu 
                245                 250                 255     


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
            260                 265                 270         


Val Thr Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys Met 
        275                 280                 285             


Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Leu Glu His His His 
    290                 295                 300                 


His His His 
305         


<210>  25
<211>  298
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CC3-GFP

<400>  25

Met Ala Arg Met Lys Gln Leu Glu Lys Glu Ala Glu Glu Leu Glu Ser 
1               5                   10                  15      


Glu Ala Gln Gln Leu Glu Lys Glu Phe Ala Gln Leu Glu Lys Glu Val 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        35                  40                  45              


Gly Ser Gly Glu Phe Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val 
    50                  55                  60                  


Pro Ile Leu Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser 
65                  70                  75                  80  


Val Arg Gly Glu Gly Glu Gly Asp Ala Thr Ile Gly Lys Leu Thr Leu 
                85                  90                  95      


Lys Phe Ile Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu 
            100                 105                 110         


Val Thr Thr Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp 
        115                 120                 125             


His Met Lys Arg His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr 
    130                 135                 140                 


Val Gln Glu Arg Thr Ile Ser Phe Lys Asp Asp Gly Lys Tyr Lys Thr 
145                 150                 155                 160 


Arg Ala Val Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu 
                165                 170                 175     


Leu Lys Gly Thr Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys 
            180                 185                 190         


Leu Glu Tyr Asn Phe Asn Ser His Asn Val Tyr Ile Thr Ala Asp Lys 
        195                 200                 205             


Gln Lys Asn Gly Ile Lys Ala Asn Phe Thr Val Arg His Asn Val Glu 
    210                 215                 220                 


Asp Gly Ser Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile 
225                 230                 235                 240 


Gly Asp Gly Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln 
                245                 250                 255     


Thr Val Leu Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu 
            260                 265                 270         


His Glu Tyr Val Asn Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu 
        275                 280                 285             


Tyr Lys Leu Glu His His His His His His 
    290                 295             


