                         SEQUENCE LISTING

<110>  UNIVERSITY OF MIAMI
 
<120>  PROTEIN AMYLOIDOGENESIS AND RELATED METHODS

<130>  32286/51075 PC

<150>  US 62/404,001
<151>  2016-10-04

<160>  200   

<170>  PatentIn version 3.5

<210>  1
<211>  213
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P40337
<309>  2016-09-07
<313>  (1)..(213)

<400>  1

Met Pro Arg Arg Ala Glu Asn Trp Asp Glu Ala Glu Val Gly Ala Glu 
1               5                   10                  15      


Glu Ala Gly Val Glu Glu Tyr Gly Pro Glu Glu Asp Gly Gly Glu Glu 
            20                  25                  30          


Ser Gly Ala Glu Glu Ser Gly Pro Glu Glu Ser Gly Pro Glu Glu Leu 
        35                  40                  45              


Gly Ala Glu Glu Glu Met Glu Ala Gly Arg Pro Arg Pro Val Leu Arg 
    50                  55                  60                  


Ser Val Asn Ser Arg Glu Pro Ser Gln Val Ile Phe Cys Asn Arg Ser 
65                  70                  75                  80  


Pro Arg Val Val Leu Pro Val Trp Leu Asn Phe Asp Gly Glu Pro Gln 
                85                  90                  95      


Pro Tyr Pro Thr Leu Pro Pro Gly Thr Gly Arg Arg Ile His Ser Tyr 
            100                 105                 110         


Arg Gly His Leu Trp Leu Phe Arg Asp Ala Gly Thr His Asp Gly Leu 
        115                 120                 125             


Leu Val Asn Gln Thr Glu Leu Phe Val Pro Ser Leu Asn Val Asp Gly 
    130                 135                 140                 


Gln Pro Ile Phe Ala Asn Ile Thr Leu Pro Val Tyr Thr Leu Lys Glu 
145                 150                 155                 160 


Arg Cys Leu Gln Val Val Arg Ser Leu Val Lys Pro Glu Asn Tyr Arg 
                165                 170                 175     


Arg Leu Asp Ile Val Arg Ser Leu Tyr Glu Asp Leu Glu Asp His Pro 
            180                 185                 190         


Asn Val Gln Lys Asp Leu Glu Arg Leu Thr Gln Glu Arg Ile Ala His 
        195                 200                 205             


Gln Arg Met Gly Asp 
    210             


<210>  2
<211>  1107
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P28340
<309>  2016-09-07
<313>  (1)..(1107)

<400>  2

Met Asp Gly Lys Arg Arg Pro Gly Pro Gly Pro Gly Val Pro Pro Lys 
1               5                   10                  15      


Arg Ala Arg Gly Gly Leu Trp Asp Asp Asp Asp Ala Pro Arg Pro Ser 
            20                  25                  30          


Gln Phe Glu Glu Asp Leu Ala Leu Met Glu Glu Met Glu Ala Glu His 
        35                  40                  45              


Arg Leu Gln Glu Gln Glu Glu Glu Glu Leu Gln Ser Val Leu Glu Gly 
    50                  55                  60                  


Val Ala Asp Gly Gln Val Pro Pro Ser Ala Ile Asp Pro Arg Trp Leu 
65                  70                  75                  80  


Arg Pro Thr Pro Pro Ala Leu Asp Pro Gln Thr Glu Pro Leu Ile Phe 
                85                  90                  95      


Gln Gln Leu Glu Ile Asp His Tyr Val Gly Pro Ala Gln Pro Val Pro 
            100                 105                 110         


Gly Gly Pro Pro Pro Ser Arg Gly Ser Val Pro Val Leu Arg Ala Phe 
        115                 120                 125             


Gly Val Thr Asp Glu Gly Phe Ser Val Cys Cys His Ile His Gly Phe 
    130                 135                 140                 


Ala Pro Tyr Phe Tyr Thr Pro Ala Pro Pro Gly Phe Gly Pro Glu His 
145                 150                 155                 160 


Met Gly Asp Leu Gln Arg Glu Leu Asn Leu Ala Ile Ser Arg Asp Ser 
                165                 170                 175     


Arg Gly Gly Arg Glu Leu Thr Gly Pro Ala Val Leu Ala Val Glu Leu 
            180                 185                 190         


Cys Ser Arg Glu Ser Met Phe Gly Tyr His Gly His Gly Pro Ser Pro 
        195                 200                 205             


Phe Leu Arg Ile Thr Val Ala Leu Pro Arg Leu Val Ala Pro Ala Arg 
    210                 215                 220                 


Arg Leu Leu Glu Gln Gly Ile Arg Val Ala Gly Leu Gly Thr Pro Ser 
225                 230                 235                 240 


Phe Ala Pro Tyr Glu Ala Asn Val Asp Phe Glu Ile Arg Phe Met Val 
                245                 250                 255     


Asp Thr Asp Ile Val Gly Cys Asn Trp Leu Glu Leu Pro Ala Gly Lys 
            260                 265                 270         


Tyr Ala Leu Arg Leu Lys Glu Lys Ala Thr Gln Cys Gln Leu Glu Ala 
        275                 280                 285             


Asp Val Leu Trp Ser Asp Val Val Ser His Pro Pro Glu Gly Pro Trp 
    290                 295                 300                 


Gln Arg Ile Ala Pro Leu Arg Val Leu Ser Phe Asp Ile Glu Cys Ala 
305                 310                 315                 320 


Gly Arg Lys Gly Ile Phe Pro Glu Pro Glu Arg Asp Pro Val Ile Gln 
                325                 330                 335     


Ile Cys Ser Leu Gly Leu Arg Trp Gly Glu Pro Glu Pro Phe Leu Arg 
            340                 345                 350         


Leu Ala Leu Thr Leu Arg Pro Cys Ala Pro Ile Leu Gly Ala Lys Val 
        355                 360                 365             


Gln Ser Tyr Glu Lys Glu Glu Asp Leu Leu Gln Ala Trp Ser Thr Phe 
    370                 375                 380                 


Ile Arg Ile Met Asp Pro Asp Val Ile Thr Gly Tyr Asn Ile Gln Asn 
385                 390                 395                 400 


Phe Asp Leu Pro Tyr Leu Ile Ser Arg Ala Gln Thr Leu Lys Val Gln 
                405                 410                 415     


Thr Phe Pro Phe Leu Gly Arg Val Ala Gly Leu Cys Ser Asn Ile Arg 
            420                 425                 430         


Asp Ser Ser Phe Gln Ser Lys Gln Thr Gly Arg Arg Asp Thr Lys Val 
        435                 440                 445             


Val Ser Met Val Gly Arg Val Gln Met Asp Met Leu Gln Val Leu Leu 
    450                 455                 460                 


Arg Glu Tyr Lys Leu Arg Ser Tyr Thr Leu Asn Ala Val Ser Phe His 
465                 470                 475                 480 


Phe Leu Gly Glu Gln Lys Glu Asp Val Gln His Ser Ile Ile Thr Asp 
                485                 490                 495     


Leu Gln Asn Gly Asn Asp Gln Thr Arg Arg Arg Leu Ala Val Tyr Cys 
            500                 505                 510         


Leu Lys Asp Ala Tyr Leu Pro Leu Arg Leu Leu Glu Arg Leu Met Val 
        515                 520                 525             


Leu Val Asn Ala Val Glu Met Ala Arg Val Thr Gly Val Pro Leu Ser 
    530                 535                 540                 


Tyr Leu Leu Ser Arg Gly Gln Gln Val Lys Val Val Ser Gln Leu Leu 
545                 550                 555                 560 


Arg Gln Ala Met His Glu Gly Leu Leu Met Pro Val Val Lys Ser Glu 
                565                 570                 575     


Gly Gly Glu Asp Tyr Thr Gly Ala Thr Val Ile Glu Pro Leu Lys Gly 
            580                 585                 590         


Tyr Tyr Asp Val Pro Ile Ala Thr Leu Asp Phe Ser Ser Leu Tyr Pro 
        595                 600                 605             


Ser Ile Met Met Ala His Asn Leu Cys Tyr Thr Thr Leu Leu Arg Pro 
    610                 615                 620                 


Gly Thr Ala Gln Lys Leu Gly Leu Thr Glu Asp Gln Phe Ile Arg Thr 
625                 630                 635                 640 


Pro Thr Gly Asp Glu Phe Val Lys Thr Ser Val Arg Lys Gly Leu Leu 
                645                 650                 655     


Pro Gln Ile Leu Glu Asn Leu Leu Ser Ala Arg Lys Arg Ala Lys Ala 
            660                 665                 670         


Glu Leu Ala Lys Glu Thr Asp Pro Leu Arg Arg Gln Val Leu Asp Gly 
        675                 680                 685             


Arg Gln Leu Ala Leu Lys Val Ser Ala Asn Ser Val Tyr Gly Phe Thr 
    690                 695                 700                 


Gly Ala Gln Val Gly Lys Leu Pro Cys Leu Glu Ile Ser Gln Ser Val 
705                 710                 715                 720 


Thr Gly Phe Gly Arg Gln Met Ile Glu Lys Thr Lys Gln Leu Val Glu 
                725                 730                 735     


Ser Lys Tyr Thr Val Glu Asn Gly Tyr Ser Thr Ser Ala Lys Val Val 
            740                 745                 750         


Tyr Gly Asp Thr Asp Ser Val Met Cys Arg Phe Gly Val Ser Ser Val 
        755                 760                 765             


Ala Glu Ala Met Ala Leu Gly Arg Glu Ala Ala Asp Trp Val Ser Gly 
    770                 775                 780                 


His Phe Pro Ser Pro Ile Arg Leu Glu Phe Glu Lys Val Tyr Phe Pro 
785                 790                 795                 800 


Tyr Leu Leu Ile Ser Lys Lys Arg Tyr Ala Gly Leu Leu Phe Ser Ser 
                805                 810                 815     


Arg Pro Asp Ala His Asp Arg Met Asp Cys Lys Gly Leu Glu Ala Val 
            820                 825                 830         


Arg Arg Asp Asn Cys Pro Leu Val Ala Asn Leu Val Thr Ala Ser Leu 
        835                 840                 845             


Arg Arg Leu Leu Ile Asp Arg Asp Pro Glu Gly Ala Val Ala His Ala 
    850                 855                 860                 


Gln Asp Val Ile Ser Asp Leu Leu Cys Asn Arg Ile Asp Ile Ser Gln 
865                 870                 875                 880 


Leu Val Ile Thr Lys Glu Leu Thr Arg Ala Ala Ser Asp Tyr Ala Gly 
                885                 890                 895     


Lys Gln Ala His Val Glu Leu Ala Glu Arg Met Arg Lys Arg Asp Pro 
            900                 905                 910         


Gly Ser Ala Pro Ser Leu Gly Asp Arg Val Pro Tyr Val Ile Ile Ser 
        915                 920                 925             


Ala Ala Lys Gly Val Ala Ala Tyr Met Lys Ser Glu Asp Pro Leu Phe 
    930                 935                 940                 


Val Leu Glu His Ser Leu Pro Ile Asp Thr Gln Tyr Tyr Leu Glu Gln 
945                 950                 955                 960 


Gln Leu Ala Lys Pro Leu Leu Arg Ile Phe Glu Pro Ile Leu Gly Glu 
                965                 970                 975     


Gly Arg Ala Glu Ala Val Leu Leu Arg Gly Asp His Thr Arg Cys Lys 
            980                 985                 990         


Thr Val Leu Thr Gly Lys Val Gly  Gly Leu Leu Ala Phe  Ala Lys Arg 
        995                 1000                 1005             


Arg Asn  Cys Cys Ile Gly Cys  Arg Thr Val Leu Ser  His Gln Gly 
    1010                 1015                 1020             


Ala Val  Cys Glu Phe Cys Gln  Pro Arg Glu Ser Glu  Leu Tyr Gln 
    1025                 1030                 1035             


Lys Glu  Val Ser His Leu Asn  Ala Leu Glu Glu Arg  Phe Ser Arg 
    1040                 1045                 1050             


Leu Trp  Thr Gln Cys Gln Arg  Cys Gln Gly Ser Leu  His Glu Asp 
    1055                 1060                 1065             


Val Ile  Cys Thr Ser Arg Asp  Cys Pro Ile Phe Tyr  Met Arg Lys 
    1070                 1075                 1080             


Lys Val  Arg Lys Asp Leu Glu  Asp Gln Glu Gln Leu  Leu Arg Arg 
    1085                 1090                 1095             


Phe Gly  Pro Pro Gly Pro Glu  Ala Trp 
    1100                 1105         


<210>  3
<211>  1616
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P26358
<309>  2016-09-07
<313>  (1)..(1616)

<400>  3

Met Pro Ala Arg Thr Ala Pro Ala Arg Val Pro Thr Leu Ala Val Pro 
1               5                   10                  15      


Ala Ile Ser Leu Pro Asp Asp Val Arg Arg Arg Leu Lys Asp Leu Glu 
            20                  25                  30          


Arg Asp Ser Leu Thr Glu Lys Glu Cys Val Lys Glu Lys Leu Asn Leu 
        35                  40                  45              


Leu His Glu Phe Leu Gln Thr Glu Ile Lys Asn Gln Leu Cys Asp Leu 
    50                  55                  60                  


Glu Thr Lys Leu Arg Lys Glu Glu Leu Ser Glu Glu Gly Tyr Leu Ala 
65                  70                  75                  80  


Lys Val Lys Ser Leu Leu Asn Lys Asp Leu Ser Leu Glu Asn Gly Ala 
                85                  90                  95      


His Ala Tyr Asn Arg Glu Val Asn Gly Arg Leu Glu Asn Gly Asn Gln 
            100                 105                 110         


Ala Arg Ser Glu Ala Arg Arg Val Gly Met Ala Asp Ala Asn Ser Pro 
        115                 120                 125             


Pro Lys Pro Leu Ser Lys Pro Arg Thr Pro Arg Arg Ser Lys Ser Asp 
    130                 135                 140                 


Gly Glu Ala Lys Pro Glu Pro Ser Pro Ser Pro Arg Ile Thr Arg Lys 
145                 150                 155                 160 


Ser Thr Arg Gln Thr Thr Ile Thr Ser His Phe Ala Lys Gly Pro Ala 
                165                 170                 175     


Lys Arg Lys Pro Gln Glu Glu Ser Glu Arg Ala Lys Ser Asp Glu Ser 
            180                 185                 190         


Ile Lys Glu Glu Asp Lys Asp Gln Asp Glu Lys Arg Arg Arg Val Thr 
        195                 200                 205             


Ser Arg Glu Arg Val Ala Arg Pro Leu Pro Ala Glu Glu Pro Glu Arg 
    210                 215                 220                 


Ala Lys Ser Gly Thr Arg Thr Glu Lys Glu Glu Glu Arg Asp Glu Lys 
225                 230                 235                 240 


Glu Glu Lys Arg Leu Arg Ser Gln Thr Lys Glu Pro Thr Pro Lys Gln 
                245                 250                 255     


Lys Leu Lys Glu Glu Pro Asp Arg Glu Ala Arg Ala Gly Val Gln Ala 
            260                 265                 270         


Asp Glu Asp Glu Asp Gly Asp Glu Lys Asp Glu Lys Lys His Arg Ser 
        275                 280                 285             


Gln Pro Lys Asp Leu Ala Ala Lys Arg Arg Pro Glu Glu Lys Glu Pro 
    290                 295                 300                 


Glu Lys Val Asn Pro Gln Ile Ser Asp Glu Lys Asp Glu Asp Glu Lys 
305                 310                 315                 320 


Glu Glu Lys Arg Arg Lys Thr Thr Pro Lys Glu Pro Thr Glu Lys Lys 
                325                 330                 335     


Met Ala Arg Ala Lys Thr Val Met Asn Ser Lys Thr His Pro Pro Lys 
            340                 345                 350         


Cys Ile Gln Cys Gly Gln Tyr Leu Asp Asp Pro Asp Leu Lys Tyr Gly 
        355                 360                 365             


Gln His Pro Pro Asp Ala Val Asp Glu Pro Gln Met Leu Thr Asn Glu 
    370                 375                 380                 


Lys Leu Ser Ile Phe Asp Ala Asn Glu Ser Gly Phe Glu Ser Tyr Glu 
385                 390                 395                 400 


Ala Leu Pro Gln His Lys Leu Thr Cys Phe Ser Val Tyr Cys Lys His 
                405                 410                 415     


Gly His Leu Cys Pro Ile Asp Thr Gly Leu Ile Glu Lys Asn Ile Glu 
            420                 425                 430         


Leu Phe Phe Ser Gly Ser Ala Lys Pro Ile Tyr Asp Asp Asp Pro Ser 
        435                 440                 445             


Leu Glu Gly Gly Val Asn Gly Lys Asn Leu Gly Pro Ile Asn Glu Trp 
    450                 455                 460                 


Trp Ile Thr Gly Phe Asp Gly Gly Glu Lys Ala Leu Ile Gly Phe Ser 
465                 470                 475                 480 


Thr Ser Phe Ala Glu Tyr Ile Leu Met Asp Pro Ser Pro Glu Tyr Ala 
                485                 490                 495     


Pro Ile Phe Gly Leu Met Gln Glu Lys Ile Tyr Ile Ser Lys Ile Val 
            500                 505                 510         


Val Glu Phe Leu Gln Ser Asn Ser Asp Ser Thr Tyr Glu Asp Leu Ile 
        515                 520                 525             


Asn Lys Ile Glu Thr Thr Val Pro Pro Ser Gly Leu Asn Leu Asn Arg 
    530                 535                 540                 


Phe Thr Glu Asp Ser Leu Leu Arg His Ala Gln Phe Val Val Glu Gln 
545                 550                 555                 560 


Val Glu Ser Tyr Asp Glu Ala Gly Asp Ser Asp Glu Gln Pro Ile Phe 
                565                 570                 575     


Leu Thr Pro Cys Met Arg Asp Leu Ile Lys Leu Ala Gly Val Thr Leu 
            580                 585                 590         


Gly Gln Arg Arg Ala Gln Ala Arg Arg Gln Thr Ile Arg His Ser Thr 
        595                 600                 605             


Arg Glu Lys Asp Arg Gly Pro Thr Lys Ala Thr Thr Thr Lys Leu Val 
    610                 615                 620                 


Tyr Gln Ile Phe Asp Thr Phe Phe Ala Glu Gln Ile Glu Lys Asp Asp 
625                 630                 635                 640 


Arg Glu Asp Lys Glu Asn Ala Phe Lys Arg Arg Arg Cys Gly Val Cys 
                645                 650                 655     


Glu Val Cys Gln Gln Pro Glu Cys Gly Lys Cys Lys Ala Cys Lys Asp 
            660                 665                 670         


Met Val Lys Phe Gly Gly Ser Gly Arg Ser Lys Gln Ala Cys Gln Glu 
        675                 680                 685             


Arg Arg Cys Pro Asn Met Ala Met Lys Glu Ala Asp Asp Asp Glu Glu 
    690                 695                 700                 


Val Asp Asp Asn Ile Pro Glu Met Pro Ser Pro Lys Lys Met His Gln 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Gln Asn Lys Asn Arg Ile Ser Trp Val Gly Glu 
                725                 730                 735     


Ala Val Lys Thr Asp Gly Lys Lys Ser Tyr Tyr Lys Lys Val Cys Ile 
            740                 745                 750         


Asp Ala Glu Thr Leu Glu Val Gly Asp Cys Val Ser Val Ile Pro Asp 
        755                 760                 765             


Asp Ser Ser Lys Pro Leu Tyr Leu Ala Arg Val Thr Ala Leu Trp Glu 
    770                 775                 780                 


Asp Ser Ser Asn Gly Gln Met Phe His Ala His Trp Phe Cys Ala Gly 
785                 790                 795                 800 


Thr Asp Thr Val Leu Gly Ala Thr Ser Asp Pro Leu Glu Leu Phe Leu 
                805                 810                 815     


Val Asp Glu Cys Glu Asp Met Gln Leu Ser Tyr Ile His Ser Lys Val 
            820                 825                 830         


Lys Val Ile Tyr Lys Ala Pro Ser Glu Asn Trp Ala Met Glu Gly Gly 
        835                 840                 845             


Met Asp Pro Glu Ser Leu Leu Glu Gly Asp Asp Gly Lys Thr Tyr Phe 
    850                 855                 860                 


Tyr Gln Leu Trp Tyr Asp Gln Asp Tyr Ala Arg Phe Glu Ser Pro Pro 
865                 870                 875                 880 


Lys Thr Gln Pro Thr Glu Asp Asn Lys Phe Lys Phe Cys Val Ser Cys 
                885                 890                 895     


Ala Arg Leu Ala Glu Met Arg Gln Lys Glu Ile Pro Arg Val Leu Glu 
            900                 905                 910         


Gln Leu Glu Asp Leu Asp Ser Arg Val Leu Tyr Tyr Ser Ala Thr Lys 
        915                 920                 925             


Asn Gly Ile Leu Tyr Arg Val Gly Asp Gly Val Tyr Leu Pro Pro Glu 
    930                 935                 940                 


Ala Phe Thr Phe Asn Ile Lys Leu Ser Ser Pro Val Lys Arg Pro Arg 
945                 950                 955                 960 


Lys Glu Pro Val Asp Glu Asp Leu Tyr Pro Glu His Tyr Arg Lys Tyr 
                965                 970                 975     


Ser Asp Tyr Ile Lys Gly Ser Asn Leu Asp Ala Pro Glu Pro Tyr Arg 
            980                 985                 990         


Ile Gly Arg Ile Lys Glu Ile Phe  Cys Pro Lys Lys Ser  Asn Gly Arg 
        995                 1000                 1005             


Pro Asn  Glu Thr Asp Ile Lys  Ile Arg Val Asn Lys  Phe Tyr Arg 
    1010                 1015                 1020             


Pro Glu  Asn Thr His Lys Ser  Thr Pro Ala Ser Tyr  His Ala Asp 
    1025                 1030                 1035             


Ile Asn  Leu Leu Tyr Trp Ser  Asp Glu Glu Ala Val  Val Asp Phe 
    1040                 1045                 1050             


Lys Ala  Val Gln Gly Arg Cys  Thr Val Glu Tyr Gly  Glu Asp Leu 
    1055                 1060                 1065             


Pro Glu  Cys Val Gln Val Tyr  Ser Met Gly Gly Pro  Asn Arg Phe 
    1070                 1075                 1080             


Tyr Phe  Leu Glu Ala Tyr Asn  Ala Lys Ser Lys Ser  Phe Glu Asp 
    1085                 1090                 1095             


Pro Pro  Asn His Ala Arg Ser  Pro Gly Asn Lys Gly  Lys Gly Lys 
    1100                 1105                 1110             


Gly Lys  Gly Lys Gly Lys Pro  Lys Ser Gln Ala Cys  Glu Pro Ser 
    1115                 1120                 1125             


Glu Pro  Glu Ile Glu Ile Lys  Leu Pro Lys Leu Arg  Thr Leu Asp 
    1130                 1135                 1140             


Val Phe  Ser Gly Cys Gly Gly  Leu Ser Glu Gly Phe  His Gln Ala 
    1145                 1150                 1155             


Gly Ile  Ser Asp Thr Leu Trp  Ala Ile Glu Met Trp  Asp Pro Ala 
    1160                 1165                 1170             


Ala Gln  Ala Phe Arg Leu Asn  Asn Pro Gly Ser Thr  Val Phe Thr 
    1175                 1180                 1185             


Glu Asp  Cys Asn Ile Leu Leu  Lys Leu Val Met Ala  Gly Glu Thr 
    1190                 1195                 1200             


Thr Asn  Ser Arg Gly Gln Arg  Leu Pro Gln Lys Gly  Asp Val Glu 
    1205                 1210                 1215             


Met Leu  Cys Gly Gly Pro Pro  Cys Gln Gly Phe Ser  Gly Met Asn 
    1220                 1225                 1230             


Arg Phe  Asn Ser Arg Thr Tyr  Ser Lys Phe Lys Asn  Ser Leu Val 
    1235                 1240                 1245             


Val Ser  Phe Leu Ser Tyr Cys  Asp Tyr Tyr Arg Pro  Arg Phe Phe 
    1250                 1255                 1260             


Leu Leu  Glu Asn Val Arg Asn  Phe Val Ser Phe Lys  Arg Ser Met 
    1265                 1270                 1275             


Val Leu  Lys Leu Thr Leu Arg  Cys Leu Val Arg Met  Gly Tyr Gln 
    1280                 1285                 1290             


Cys Thr  Phe Gly Val Leu Gln  Ala Gly Gln Tyr Gly  Val Ala Gln 
    1295                 1300                 1305             


Thr Arg  Arg Arg Ala Ile Ile  Leu Ala Ala Ala Pro  Gly Glu Lys 
    1310                 1315                 1320             


Leu Pro  Leu Phe Pro Glu Pro  Leu His Val Phe Ala  Pro Arg Ala 
    1325                 1330                 1335             


Cys Gln  Leu Ser Val Val Val  Asp Asp Lys Lys Phe  Val Ser Asn 
    1340                 1345                 1350             


Ile Thr  Arg Leu Ser Ser Gly  Pro Phe Arg Thr Ile  Thr Val Arg 
    1355                 1360                 1365             


Asp Thr  Met Ser Asp Leu Pro  Glu Val Arg Asn Gly  Ala Ser Ala 
    1370                 1375                 1380             


Leu Glu  Ile Ser Tyr Asn Gly  Glu Pro Gln Ser Trp  Phe Gln Arg 
    1385                 1390                 1395             


Gln Leu  Arg Gly Ala Gln Tyr  Gln Pro Ile Leu Arg  Asp His Ile 
    1400                 1405                 1410             


Cys Lys  Asp Met Ser Ala Leu  Val Ala Ala Arg Met  Arg His Ile 
    1415                 1420                 1425             


Pro Leu  Ala Pro Gly Ser Asp  Trp Arg Asp Leu Pro  Asn Ile Glu 
    1430                 1435                 1440             


Val Arg  Leu Ser Asp Gly Thr  Met Ala Arg Lys Leu  Arg Tyr Thr 
    1445                 1450                 1455             


His His  Asp Arg Lys Asn Gly  Arg Ser Ser Ser Gly  Ala Leu Arg 
    1460                 1465                 1470             


Gly Val  Cys Ser Cys Val Glu  Ala Gly Lys Ala Cys  Asp Pro Ala 
    1475                 1480                 1485             


Ala Arg  Gln Phe Asn Thr Leu  Ile Pro Trp Cys Leu  Pro His Thr 
    1490                 1495                 1500             


Gly Asn  Arg His Asn His Trp  Ala Gly Leu Tyr Gly  Arg Leu Glu 
    1505                 1510                 1515             


Trp Asp  Gly Phe Phe Ser Thr  Thr Val Thr Asn Pro  Glu Pro Met 
    1520                 1525                 1530             


Gly Lys  Gln Gly Arg Val Leu  His Pro Glu Gln His  Arg Val Val 
    1535                 1540                 1545             


Ser Val  Arg Glu Cys Ala Arg  Ser Gln Gly Phe Pro  Asp Thr Tyr 
    1550                 1555                 1560             


Arg Leu  Phe Gly Asn Ile Leu  Asp Lys His Arg Gln  Val Gly Asn 
    1565                 1570                 1575             


Ala Val  Pro Pro Pro Leu Ala  Lys Ala Ile Gly Leu  Glu Ile Lys 
    1580                 1585                 1590             


Leu Cys  Met Leu Ala Lys Ala  Arg Glu Ser Ala Ser  Ala Lys Ile 
    1595                 1600                 1605             


Lys Glu  Glu Glu Ala Ala Lys  Asp 
    1610                 1615     


<210>  4
<211>  485
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O76064
<309>  2016-09-07
<313>  (1)..(485)

<400>  4

Met Gly Glu Pro Gly Phe Phe Val Thr Gly Asp Arg Ala Gly Gly Arg 
1               5                   10                  15      


Ser Trp Cys Leu Arg Arg Val Gly Met Ser Ala Gly Trp Leu Leu Leu 
            20                  25                  30          


Glu Asp Gly Cys Glu Val Thr Val Gly Arg Gly Phe Gly Val Thr Tyr 
        35                  40                  45              


Gln Leu Val Ser Lys Ile Cys Pro Leu Met Ile Ser Arg Asn His Cys 
    50                  55                  60                  


Val Leu Lys Gln Asn Pro Glu Gly Gln Trp Thr Ile Met Asp Asn Lys 
65                  70                  75                  80  


Ser Leu Asn Gly Val Trp Leu Asn Arg Ala Arg Leu Glu Pro Leu Arg 
                85                  90                  95      


Val Tyr Ser Ile His Gln Gly Asp Tyr Ile Gln Leu Gly Val Pro Leu 
            100                 105                 110         


Glu Asn Lys Glu Asn Ala Glu Tyr Glu Tyr Glu Val Thr Glu Glu Asp 
        115                 120                 125             


Trp Glu Thr Ile Tyr Pro Cys Leu Ser Pro Lys Asn Asp Gln Met Ile 
    130                 135                 140                 


Glu Lys Asn Lys Glu Leu Arg Thr Lys Arg Lys Phe Ser Leu Asp Glu 
145                 150                 155                 160 


Leu Ala Gly Pro Gly Ala Glu Gly Pro Ser Asn Leu Lys Ser Lys Ile 
                165                 170                 175     


Asn Lys Val Ser Cys Glu Ser Gly Gln Pro Val Lys Ser Gln Gly Lys 
            180                 185                 190         


Gly Glu Val Ala Ser Thr Pro Ser Asp Asn Leu Asp Pro Lys Leu Thr 
        195                 200                 205             


Ala Leu Glu Pro Ser Lys Thr Thr Gly Ala Pro Ile Tyr Pro Gly Phe 
    210                 215                 220                 


Pro Lys Val Thr Glu Val His His Glu Gln Lys Ala Ser Asn Ser Ser 
225                 230                 235                 240 


Ala Ser Gln Arg Ser Leu Gln Met Phe Lys Val Thr Met Ser Arg Ile 
                245                 250                 255     


Leu Arg Leu Lys Ile Gln Met Gln Glu Lys His Glu Ala Val Met Asn 
            260                 265                 270         


Val Lys Lys Gln Thr Gln Lys Gly Asn Ser Lys Lys Val Val Gln Met 
        275                 280                 285             


Glu Gln Glu Leu Gln Asp Leu Gln Ser Gln Leu Cys Ala Glu Gln Ala 
    290                 295                 300                 


Gln Gln Gln Ala Arg Val Glu Gln Leu Glu Lys Thr Phe Gln Glu Glu 
305                 310                 315                 320 


Glu Gln His Leu Gln Gly Leu Glu Ile Ala Gln Gly Glu Lys Asp Leu 
                325                 330                 335     


Lys Gln Gln Leu Ala Gln Ala Leu Gln Glu His Trp Ala Leu Met Glu 
            340                 345                 350         


Glu Leu Asn Arg Ser Lys Lys Asp Phe Glu Ala Ile Ile Gln Ala Lys 
        355                 360                 365             


Asn Lys Glu Leu Glu Gln Thr Lys Glu Glu Lys Glu Lys Met Gln Ala 
    370                 375                 380                 


Gln Lys Glu Glu Val Leu Ser His Met Asn Asp Val Leu Glu Asn Glu 
385                 390                 395                 400 


Leu Gln Cys Ile Ile Cys Ser Glu Tyr Phe Ile Glu Ala Val Thr Leu 
                405                 410                 415     


Asn Cys Ala His Ser Phe Cys Ser Tyr Cys Ile Asn Glu Trp Met Lys 
            420                 425                 430         


Arg Lys Ile Glu Cys Pro Ile Cys Arg Lys Asp Ile Lys Ser Lys Thr 
        435                 440                 445             


Tyr Ser Leu Val Leu Asp Asn Cys Ile Asn Lys Met Val Asn Asn Leu 
    450                 455                 460                 


Ser Ser Glu Val Lys Glu Arg Arg Ile Val Leu Ile Arg Glu Arg Lys 
465                 470                 475                 480 


Ala Lys Arg Leu Phe 
                485 


<210>  5
<211>  491
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q00987
<309>  2016-09-07
<313>  (1)..(491)

<400>  5

Met Cys Asn Thr Asn Met Ser Val Pro Thr Asp Gly Ala Val Thr Thr 
1               5                   10                  15      


Ser Gln Ile Pro Ala Ser Glu Gln Glu Thr Leu Val Arg Pro Lys Pro 
            20                  25                  30          


Leu Leu Leu Lys Leu Leu Lys Ser Val Gly Ala Gln Lys Asp Thr Tyr 
        35                  40                  45              


Thr Met Lys Glu Val Leu Phe Tyr Leu Gly Gln Tyr Ile Met Thr Lys 
    50                  55                  60                  


Arg Leu Tyr Asp Glu Lys Gln Gln His Ile Val Tyr Cys Ser Asn Asp 
65                  70                  75                  80  


Leu Leu Gly Asp Leu Phe Gly Val Pro Ser Phe Ser Val Lys Glu His 
                85                  90                  95      


Arg Lys Ile Tyr Thr Met Ile Tyr Arg Asn Leu Val Val Val Asn Gln 
            100                 105                 110         


Gln Glu Ser Ser Asp Ser Gly Thr Ser Val Ser Glu Asn Arg Cys His 
        115                 120                 125             


Leu Glu Gly Gly Ser Asp Gln Lys Asp Leu Val Gln Glu Leu Gln Glu 
    130                 135                 140                 


Glu Lys Pro Ser Ser Ser His Leu Val Ser Arg Pro Ser Thr Ser Ser 
145                 150                 155                 160 


Arg Arg Arg Ala Ile Ser Glu Thr Glu Glu Asn Ser Asp Glu Leu Ser 
                165                 170                 175     


Gly Glu Arg Gln Arg Lys Arg His Lys Ser Asp Ser Ile Ser Leu Ser 
            180                 185                 190         


Phe Asp Glu Ser Leu Ala Leu Cys Val Ile Arg Glu Ile Cys Cys Glu 
        195                 200                 205             


Arg Ser Ser Ser Ser Glu Ser Thr Gly Thr Pro Ser Asn Pro Asp Leu 
    210                 215                 220                 


Asp Ala Gly Val Ser Glu His Ser Gly Asp Trp Leu Asp Gln Asp Ser 
225                 230                 235                 240 


Val Ser Asp Gln Phe Ser Val Glu Phe Glu Val Glu Ser Leu Asp Ser 
                245                 250                 255     


Glu Asp Tyr Ser Leu Ser Glu Glu Gly Gln Glu Leu Ser Asp Glu Asp 
            260                 265                 270         


Asp Glu Val Tyr Gln Val Thr Val Tyr Gln Ala Gly Glu Ser Asp Thr 
        275                 280                 285             


Asp Ser Phe Glu Glu Asp Pro Glu Ile Ser Leu Ala Asp Tyr Trp Lys 
    290                 295                 300                 


Cys Thr Ser Cys Asn Glu Met Asn Pro Pro Leu Pro Ser His Cys Asn 
305                 310                 315                 320 


Arg Cys Trp Ala Leu Arg Glu Asn Trp Leu Pro Glu Asp Lys Gly Lys 
                325                 330                 335     


Asp Lys Gly Glu Ile Ser Glu Lys Ala Lys Leu Glu Asn Ser Thr Gln 
            340                 345                 350         


Ala Glu Glu Gly Phe Asp Val Pro Asp Cys Lys Lys Thr Ile Val Asn 
        355                 360                 365             


Asp Ser Arg Glu Ser Cys Val Glu Glu Asn Asp Asp Lys Ile Thr Gln 
    370                 375                 380                 


Ala Ser Gln Ser Gln Glu Ser Glu Asp Tyr Ser Gln Pro Ser Thr Ser 
385                 390                 395                 400 


Ser Ser Ile Ile Tyr Ser Ser Gln Glu Asp Val Lys Glu Phe Glu Arg 
                405                 410                 415     


Glu Glu Thr Gln Asp Lys Glu Glu Ser Val Glu Ser Ser Leu Pro Leu 
            420                 425                 430         


Asn Ala Ile Glu Pro Cys Val Ile Cys Gln Gly Arg Pro Lys Asn Gly 
        435                 440                 445             


Cys Ile Val His Gly Lys Thr Gly His Leu Met Ala Cys Phe Thr Cys 
    450                 455                 460                 


Ala Lys Lys Leu Lys Lys Arg Asn Lys Pro Cys Pro Val Cys Arg Gln 
465                 470                 475                 480 


Pro Ile Gln Met Ile Val Leu Thr Tyr Phe Pro 
                485                 490     


<210>  6
<211>  822
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9UJX6
<309>  2016-09-07
<313>  (1)..(822)

<400>  6

Met Ala Ala Ala Val Val Val Ala Glu Gly Asp Ser Asp Ser Arg Pro 
1               5                   10                  15      


Gly Gln Glu Leu Leu Val Ala Trp Asn Thr Val Ser Thr Gly Leu Val 
            20                  25                  30          


Pro Pro Ala Ala Leu Gly Leu Val Ser Ser Arg Thr Ser Gly Ala Val 
        35                  40                  45              


Pro Pro Lys Glu Glu Glu Leu Arg Ala Ala Val Glu Val Leu Arg Gly 
    50                  55                  60                  


His Gly Leu His Ser Val Leu Glu Glu Trp Phe Val Glu Val Leu Gln 
65                  70                  75                  80  


Asn Asp Leu Gln Ala Asn Ile Ser Pro Glu Phe Trp Asn Ala Ile Ser 
                85                  90                  95      


Gln Cys Glu Asn Ser Ala Asp Glu Pro Gln Cys Leu Leu Leu Leu Leu 
            100                 105                 110         


Asp Ala Phe Gly Leu Leu Glu Ser Arg Leu Asp Pro Tyr Leu Arg Ser 
        115                 120                 125             


Leu Glu Leu Leu Glu Lys Trp Thr Arg Leu Gly Leu Leu Met Gly Thr 
    130                 135                 140                 


Gly Ala Gln Gly Leu Arg Glu Glu Val His Thr Met Leu Arg Gly Val 
145                 150                 155                 160 


Leu Phe Phe Ser Thr Pro Arg Thr Phe Gln Glu Met Ile Gln Arg Leu 
                165                 170                 175     


Tyr Gly Cys Phe Leu Arg Val Tyr Met Gln Ser Lys Arg Lys Gly Glu 
            180                 185                 190         


Gly Gly Thr Asp Pro Glu Leu Glu Gly Glu Leu Asp Ser Arg Tyr Ala 
        195                 200                 205             


Arg Arg Arg Tyr Tyr Arg Leu Leu Gln Ser Pro Leu Cys Ala Gly Cys 
    210                 215                 220                 


Ser Ser Asp Lys Gln Gln Cys Trp Cys Arg Gln Ala Leu Glu Gln Phe 
225                 230                 235                 240 


His Gln Leu Ser Gln Val Leu His Arg Leu Ser Leu Leu Glu Arg Val 
                245                 250                 255     


Ser Ala Glu Ala Val Thr Thr Thr Leu His Gln Val Thr Arg Glu Arg 
            260                 265                 270         


Met Glu Asp Arg Cys Arg Gly Glu Tyr Glu Arg Ser Phe Leu Arg Glu 
        275                 280                 285             


Phe His Lys Trp Ile Glu Arg Val Val Gly Trp Leu Gly Lys Val Phe 
    290                 295                 300                 


Leu Gln Asp Gly Pro Ala Arg Pro Ala Ser Pro Glu Ala Gly Asn Thr 
305                 310                 315                 320 


Leu Arg Arg Trp Arg Cys His Val Gln Arg Phe Phe Tyr Arg Ile Tyr 
                325                 330                 335     


Ala Ser Leu Arg Ile Glu Glu Leu Phe Ser Ile Val Arg Asp Phe Pro 
            340                 345                 350         


Asp Ser Arg Pro Ala Ile Glu Asp Leu Lys Tyr Cys Leu Glu Arg Thr 
        355                 360                 365             


Asp Gln Arg Gln Gln Leu Leu Val Ser Leu Lys Ala Ala Leu Glu Thr 
    370                 375                 380                 


Arg Leu Leu His Pro Gly Val Asn Thr Cys Asp Ile Ile Thr Leu Tyr 
385                 390                 395                 400 


Ile Ser Ala Ile Lys Ala Leu Arg Val Leu Asp Pro Ser Met Val Ile 
                405                 410                 415     


Leu Glu Val Ala Cys Glu Pro Ile Arg Arg Tyr Leu Arg Thr Arg Glu 
            420                 425                 430         


Asp Thr Val Arg Gln Ile Val Ala Gly Leu Thr Gly Asp Ser Asp Gly 
        435                 440                 445             


Thr Gly Asp Leu Ala Val Glu Leu Ser Lys Thr Asp Pro Ala Ser Leu 
    450                 455                 460                 


Glu Thr Gly Gln Asp Ser Glu Asp Asp Ser Gly Glu Pro Glu Asp Trp 
465                 470                 475                 480 


Val Pro Asp Pro Val Asp Ala Asp Pro Gly Lys Ser Ser Ser Lys Arg 
                485                 490                 495     


Arg Ser Ser Asp Ile Ile Ser Leu Leu Val Ser Ile Tyr Gly Ser Lys 
            500                 505                 510         


Asp Leu Phe Ile Asn Glu Tyr Arg Ser Leu Leu Ala Asp Arg Leu Leu 
        515                 520                 525             


His Gln Phe Ser Phe Ser Pro Glu Arg Glu Ile Arg Asn Val Glu Leu 
    530                 535                 540                 


Leu Lys Leu Arg Phe Gly Glu Ala Pro Met His Phe Cys Glu Val Met 
545                 550                 555                 560 


Leu Lys Asp Met Ala Asp Ser Arg Arg Ile Asn Ala Asn Ile Arg Glu 
                565                 570                 575     


Glu Asp Glu Lys Arg Pro Ala Glu Glu Gln Pro Pro Phe Gly Val Tyr 
            580                 585                 590         


Ala Val Ile Leu Ser Ser Glu Phe Trp Pro Pro Phe Lys Asp Glu Lys 
        595                 600                 605             


Leu Glu Val Pro Glu Asp Ile Arg Ala Ala Leu Glu Ala Tyr Cys Lys 
    610                 615                 620                 


Lys Tyr Glu Gln Leu Lys Ala Met Arg Thr Leu Ser Trp Lys His Thr 
625                 630                 635                 640 


Leu Gly Leu Val Thr Met Asp Val Glu Leu Ala Asp Arg Thr Leu Ser 
                645                 650                 655     


Val Ala Val Thr Pro Val Gln Ala Val Ile Leu Leu Tyr Phe Gln Asp 
            660                 665                 670         


Gln Ala Ser Trp Thr Leu Glu Glu Leu Ser Lys Ala Val Lys Met Pro 
        675                 680                 685             


Val Ala Leu Leu Arg Arg Arg Met Ser Val Trp Leu Gln Gln Gly Val 
    690                 695                 700                 


Leu Arg Glu Glu Pro Pro Gly Thr Phe Ser Val Ile Glu Glu Glu Arg 
705                 710                 715                 720 


Pro Gln Asp Arg Asp Asn Met Val Leu Ile Asp Ser Asp Asp Glu Ser 
                725                 730                 735     


Asp Ser Gly Met Ala Ser Gln Ala Asp Gln Lys Glu Glu Glu Leu Leu 
            740                 745                 750         


Leu Phe Trp Thr Tyr Ile Gln Ala Met Leu Thr Asn Leu Glu Ser Leu 
        755                 760                 765             


Ser Leu Asp Arg Ile Tyr Asn Met Leu Arg Met Phe Val Val Thr Gly 
    770                 775                 780                 


Pro Ala Leu Ala Glu Ile Asp Leu Gln Glu Leu Gln Gly Tyr Leu Gln 
785                 790                 795                 800 


Lys Lys Val Arg Asp Gln Gln Leu Val Tyr Ser Ala Gly Val Tyr Arg 
                805                 810                 815     


Leu Pro Lys Asn Cys Ser 
            820         


<210>  7
<211>  406
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P62195
<309>  2016-09-07
<313>  (1)..(406)

<400>  7

Met Ala Leu Asp Gly Pro Glu Gln Met Glu Leu Glu Glu Gly Lys Ala 
1               5                   10                  15      


Gly Ser Gly Leu Arg Gln Tyr Tyr Leu Ser Lys Ile Glu Glu Leu Gln 
            20                  25                  30          


Leu Ile Val Asn Asp Lys Ser Gln Asn Leu Arg Arg Leu Gln Ala Gln 
        35                  40                  45              


Arg Asn Glu Leu Asn Ala Lys Val Arg Leu Leu Arg Glu Glu Leu Gln 
    50                  55                  60                  


Leu Leu Gln Glu Gln Gly Ser Tyr Val Gly Glu Val Val Arg Ala Met 
65                  70                  75                  80  


Asp Lys Lys Lys Val Leu Val Lys Val His Pro Glu Gly Lys Phe Val 
                85                  90                  95      


Val Asp Val Asp Lys Asn Ile Asp Ile Asn Asp Val Thr Pro Asn Cys 
            100                 105                 110         


Arg Val Ala Leu Arg Asn Asp Ser Tyr Thr Leu His Lys Ile Leu Pro 
        115                 120                 125             


Asn Lys Val Asp Pro Leu Val Ser Leu Met Met Val Glu Lys Val Pro 
    130                 135                 140                 


Asp Ser Thr Tyr Glu Met Ile Gly Gly Leu Asp Lys Gln Ile Lys Glu 
145                 150                 155                 160 


Ile Lys Glu Val Ile Glu Leu Pro Val Lys His Pro Glu Leu Phe Glu 
                165                 170                 175     


Ala Leu Gly Ile Ala Gln Pro Lys Gly Val Leu Leu Tyr Gly Pro Pro 
            180                 185                 190         


Gly Thr Gly Lys Thr Leu Leu Ala Arg Ala Val Ala His His Thr Asp 
        195                 200                 205             


Cys Thr Phe Ile Arg Val Ser Gly Ser Glu Leu Val Gln Lys Phe Ile 
    210                 215                 220                 


Gly Glu Gly Ala Arg Met Val Arg Glu Leu Phe Val Met Ala Arg Glu 
225                 230                 235                 240 


His Ala Pro Ser Ile Ile Phe Met Asp Glu Ile Asp Ser Ile Gly Ser 
                245                 250                 255     


Ser Arg Leu Glu Gly Gly Ser Gly Gly Asp Ser Glu Val Gln Arg Thr 
            260                 265                 270         


Met Leu Glu Leu Leu Asn Gln Leu Asp Gly Phe Glu Ala Thr Lys Asn 
        275                 280                 285             


Ile Lys Val Ile Met Ala Thr Asn Arg Ile Asp Ile Leu Asp Ser Ala 
    290                 295                 300                 


Leu Leu Arg Pro Gly Arg Ile Asp Arg Lys Ile Glu Phe Pro Pro Pro 
305                 310                 315                 320 


Asn Glu Glu Ala Arg Leu Asp Ile Leu Lys Ile His Ser Arg Lys Met 
                325                 330                 335     


Asn Leu Thr Arg Gly Ile Asn Leu Arg Lys Ile Ala Glu Leu Met Pro 
            340                 345                 350         


Gly Ala Ser Gly Ala Glu Val Lys Gly Val Cys Thr Glu Ala Gly Met 
        355                 360                 365             


Tyr Ala Leu Arg Glu Arg Arg Val His Val Thr Gln Glu Asp Phe Glu 
    370                 375                 380                 


Met Ala Val Ala Lys Val Met Gln Lys Asp Ser Glu Lys Asn Met Ser 
385                 390                 395                 400 


Ile Lys Lys Leu Trp Lys 
                405     


<210>  8
<211>  423
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P11474
<309>  2016-09-07
<313>  (1)..(423)

<400>  8

Met Ser Ser Gln Val Val Gly Ile Glu Pro Leu Tyr Ile Lys Ala Glu 
1               5                   10                  15      


Pro Ala Ser Pro Asp Ser Pro Lys Gly Ser Ser Glu Thr Glu Thr Glu 
            20                  25                  30          


Pro Pro Val Ala Leu Ala Pro Gly Pro Ala Pro Thr Arg Cys Leu Pro 
        35                  40                  45              


Gly His Lys Glu Glu Glu Asp Gly Glu Gly Ala Gly Pro Gly Glu Gln 
    50                  55                  60                  


Gly Gly Gly Lys Leu Val Leu Ser Ser Leu Pro Lys Arg Leu Cys Leu 
65                  70                  75                  80  


Val Cys Gly Asp Val Ala Ser Gly Tyr His Tyr Gly Val Ala Ser Cys 
                85                  90                  95      


Glu Ala Cys Lys Ala Phe Phe Lys Arg Thr Ile Gln Gly Ser Ile Glu 
            100                 105                 110         


Tyr Ser Cys Pro Ala Ser Asn Glu Cys Glu Ile Thr Lys Arg Arg Arg 
        115                 120                 125             


Lys Ala Cys Gln Ala Cys Arg Phe Thr Lys Cys Leu Arg Val Gly Met 
    130                 135                 140                 


Leu Lys Glu Gly Val Arg Leu Asp Arg Val Arg Gly Gly Arg Gln Lys 
145                 150                 155                 160 


Tyr Lys Arg Arg Pro Glu Val Asp Pro Leu Pro Phe Pro Gly Pro Phe 
                165                 170                 175     


Pro Ala Gly Pro Leu Ala Val Ala Gly Gly Pro Arg Lys Thr Ala Ala 
            180                 185                 190         


Pro Val Asn Ala Leu Val Ser His Leu Leu Val Val Glu Pro Glu Lys 
        195                 200                 205             


Leu Tyr Ala Met Pro Asp Pro Ala Gly Pro Asp Gly His Leu Pro Ala 
    210                 215                 220                 


Val Ala Thr Leu Cys Asp Leu Phe Asp Arg Glu Ile Val Val Thr Ile 
225                 230                 235                 240 


Ser Trp Ala Lys Ser Ile Pro Gly Phe Ser Ser Leu Ser Leu Ser Asp 
                245                 250                 255     


Gln Met Ser Val Leu Gln Ser Val Trp Met Glu Val Leu Val Leu Gly 
            260                 265                 270         


Val Ala Gln Arg Ser Leu Pro Leu Gln Asp Glu Leu Ala Phe Ala Glu 
        275                 280                 285             


Asp Leu Val Leu Asp Glu Glu Gly Ala Arg Ala Ala Gly Leu Gly Glu 
    290                 295                 300                 


Leu Gly Ala Ala Leu Leu Gln Leu Val Arg Arg Leu Gln Ala Leu Arg 
305                 310                 315                 320 


Leu Glu Arg Glu Glu Tyr Val Leu Leu Lys Ala Leu Ala Leu Ala Asn 
                325                 330                 335     


Ser Asp Ser Val His Ile Glu Asp Ala Glu Ala Val Glu Gln Leu Arg 
            340                 345                 350         


Glu Ala Leu His Glu Ala Leu Leu Glu Tyr Glu Ala Gly Arg Ala Gly 
        355                 360                 365             


Pro Gly Gly Gly Ala Glu Arg Arg Arg Ala Gly Arg Leu Leu Leu Thr 
    370                 375                 380                 


Leu Pro Leu Leu Arg Gln Thr Ala Gly Lys Val Leu Ala His Phe Tyr 
385                 390                 395                 400 


Gly Val Lys Leu Glu Gly Lys Val Pro Met His Lys Leu Phe Leu Glu 
                405                 410                 415     


Met Leu Glu Ala Met Met Asp 
            420             


<210>  9
<211>  1591
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q13009
<309>  2016-09-07
<313>  (1)..(1591)

<400>  9

Met Gly Asn Ala Glu Ser Gln His Val Glu His Glu Phe Tyr Gly Glu 
1               5                   10                  15      


Lys His Ala Ser Leu Gly Arg Lys His Thr Ser Arg Ser Leu Arg Leu 
            20                  25                  30          


Ser His Lys Thr Arg Arg Thr Arg His Ala Ser Ser Gly Lys Val Ile 
        35                  40                  45              


His Arg Asn Ser Glu Val Ser Thr Arg Ser Ser Ser Thr Pro Ser Ile 
    50                  55                  60                  


Pro Gln Ser Leu Ala Glu Asn Gly Leu Glu Pro Phe Ser Gln Asp Gly 
65                  70                  75                  80  


Thr Leu Glu Asp Phe Gly Ser Pro Ile Trp Val Asp Arg Val Asp Met 
                85                  90                  95      


Gly Leu Arg Pro Val Ser Tyr Thr Asp Ser Ser Val Thr Pro Ser Val 
            100                 105                 110         


Asp Ser Ser Ile Val Leu Thr Ala Ala Ser Val Gln Ser Met Pro Asp 
        115                 120                 125             


Thr Glu Glu Ser Arg Leu Tyr Gly Asp Asp Ala Thr Tyr Leu Ala Glu 
    130                 135                 140                 


Gly Gly Arg Arg Gln His Ser Tyr Thr Ser Asn Gly Pro Thr Phe Met 
145                 150                 155                 160 


Glu Thr Ala Ser Phe Lys Lys Lys Arg Ser Lys Ser Ala Asp Ile Trp 
                165                 170                 175     


Arg Glu Asp Ser Leu Glu Phe Ser Leu Ser Asp Leu Ser Gln Glu His 
            180                 185                 190         


Leu Thr Ser Asn Glu Glu Ile Leu Gly Ser Ala Glu Glu Lys Asp Cys 
        195                 200                 205             


Glu Glu Ala Arg Gly Met Glu Thr Arg Ala Ser Pro Arg Gln Leu Ser 
    210                 215                 220                 


Thr Cys Gln Arg Ala Asn Ser Leu Gly Asp Leu Tyr Ala Gln Lys Asn 
225                 230                 235                 240 


Ser Gly Val Thr Ala Asn Gly Gly Pro Gly Ser Lys Phe Ala Gly Tyr 
                245                 250                 255     


Cys Arg Asn Leu Val Ser Asp Ile Pro Asn Leu Ala Asn His Lys Met 
            260                 265                 270         


Pro Pro Ala Ala Ala Glu Glu Thr Pro Pro Tyr Ser Asn Tyr Asn Thr 
        275                 280                 285             


Leu Pro Cys Arg Lys Ser His Cys Leu Ser Glu Gly Ala Thr Asn Pro 
    290                 295                 300                 


Gln Ile Ser His Ser Asn Ser Met Gln Gly Arg Arg Ala Lys Thr Thr 
305                 310                 315                 320 


Gln Asp Val Asn Ala Gly Glu Gly Ser Glu Phe Ala Asp Ser Gly Ile 
                325                 330                 335     


Glu Gly Ala Thr Thr Asp Thr Asp Leu Leu Ser Arg Arg Ser Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Tyr Ser Pro Thr Thr Gly Arg Ala Phe Val Gly Ser 
        355                 360                 365             


Asp Ser Gly Ser Ser Ser Thr Gly Asp Ala Ala Arg Gln Gly Val Tyr 
    370                 375                 380                 


Glu Asn Phe Arg Arg Glu Leu Glu Met Ser Thr Thr Asn Ser Glu Ser 
385                 390                 395                 400 


Leu Glu Glu Ala Gly Ser Ala His Ser Asp Glu Gln Ser Ser Gly Thr 
                405                 410                 415     


Leu Ser Ser Pro Gly Gln Ser Asp Ile Leu Leu Thr Ala Ala Gln Gly 
            420                 425                 430         


Thr Val Arg Lys Ala Gly Ala Leu Ala Val Lys Asn Phe Leu Val His 
        435                 440                 445             


Lys Lys Asn Lys Lys Val Glu Ser Ala Thr Arg Arg Lys Trp Lys His 
    450                 455                 460                 


Tyr Trp Val Ser Leu Lys Gly Cys Thr Leu Phe Phe Tyr Glu Ser Asp 
465                 470                 475                 480 


Gly Arg Ser Gly Ile Asp His Asn Ser Ile Pro Lys His Ala Val Trp 
                485                 490                 495     


Val Glu Asn Ser Ile Val Gln Ala Val Pro Glu His Pro Lys Lys Asp 
            500                 505                 510         


Phe Val Phe Cys Leu Ser Asn Ser Leu Gly Asp Ala Phe Leu Phe Gln 
        515                 520                 525             


Thr Thr Ser Gln Thr Glu Leu Glu Asn Trp Ile Thr Ala Ile His Ser 
    530                 535                 540                 


Ala Cys Ala Thr Ala Val Ala Arg His His His Lys Glu Asp Thr Leu 
545                 550                 555                 560 


Arg Leu Leu Lys Ser Glu Ile Lys Lys Leu Glu Gln Lys Ile Asp Met 
                565                 570                 575     


Asp Glu Lys Met Lys Lys Met Gly Glu Met Gln Leu Ser Ser Val Thr 
            580                 585                 590         


Asp Ser Lys Lys Lys Lys Thr Ile Leu Asp Gln Ile Phe Val Trp Glu 
        595                 600                 605             


Gln Asn Leu Glu Gln Phe Gln Met Asp Leu Phe Arg Phe Arg Cys Tyr 
    610                 615                 620                 


Leu Ala Ser Leu Gln Gly Gly Glu Leu Pro Asn Pro Lys Arg Leu Leu 
625                 630                 635                 640 


Ala Phe Ala Ser Arg Pro Thr Lys Val Ala Met Gly Arg Leu Gly Ile 
                645                 650                 655     


Phe Ser Val Ser Ser Phe His Ala Leu Val Ala Ala Arg Thr Gly Glu 
            660                 665                 670         


Thr Gly Val Arg Arg Arg Thr Gln Ala Met Ser Arg Ser Ala Ser Lys 
        675                 680                 685             


Arg Arg Ser Arg Phe Ser Ser Leu Trp Gly Leu Asp Thr Thr Ser Lys 
    690                 695                 700                 


Lys Lys Gln Gly Arg Pro Ser Ile Asn Gln Val Phe Gly Glu Gly Thr 
705                 710                 715                 720 


Glu Ala Val Lys Lys Ser Leu Glu Gly Ile Phe Asp Asp Ile Val Pro 
                725                 730                 735     


Asp Gly Lys Arg Glu Lys Glu Val Val Leu Pro Asn Val His Gln His 
            740                 745                 750         


Asn Pro Asp Cys Asp Ile Trp Val His Glu Tyr Phe Thr Pro Ser Trp 
        755                 760                 765             


Phe Cys Leu Pro Asn Asn Gln Pro Ala Leu Thr Val Val Arg Pro Gly 
    770                 775                 780                 


Asp Thr Ala Arg Asp Thr Leu Glu Leu Ile Cys Lys Thr His Gln Leu 
785                 790                 795                 800 


Asp His Ser Ala His Tyr Leu Arg Leu Lys Phe Leu Ile Glu Asn Lys 
                805                 810                 815     


Met Gln Leu Tyr Val Pro Gln Pro Glu Glu Asp Ile Tyr Glu Leu Leu 
            820                 825                 830         


Tyr Lys Glu Ile Glu Ile Cys Pro Lys Val Thr Gln Ser Ile His Ile 
        835                 840                 845             


Glu Lys Ser Asp Thr Ala Ala Asp Thr Tyr Gly Phe Ser Leu Ser Ser 
    850                 855                 860                 


Val Glu Glu Asp Gly Ile Arg Arg Leu Tyr Val Asn Ser Val Lys Glu 
865                 870                 875                 880 


Thr Gly Leu Ala Ser Lys Lys Gly Leu Lys Ala Gly Asp Glu Ile Leu 
                885                 890                 895     


Glu Ile Asn Asn Arg Ala Ala Asp Ala Leu Asn Ser Ser Met Leu Lys 
            900                 905                 910         


Asp Phe Leu Ser Gln Pro Ser Leu Gly Leu Leu Val Arg Thr Tyr Pro 
        915                 920                 925             


Glu Leu Glu Glu Gly Val Glu Leu Leu Glu Ser Pro Pro His Arg Val 
    930                 935                 940                 


Asp Gly Pro Ala Asp Leu Gly Glu Ser Pro Leu Ala Phe Leu Thr Ser 
945                 950                 955                 960 


Asn Pro Gly His Ser Leu Cys Ser Glu Gln Gly Ser Ser Ala Glu Thr 
                965                 970                 975     


Ala Pro Glu Glu Thr Glu Gly Pro Asp Leu Glu Ser Ser Asp Glu Thr 
            980                 985                 990         


Asp His Ser Ser Lys Ser Thr Glu  Gln Val Ala Ala Phe  Cys Arg Ser 
        995                 1000                 1005             


Leu His  Glu Met Asn Pro Ser  Asp Gln Ser Pro Ser  Pro Gln Asp 
    1010                 1015                 1020             


Ser Thr  Gly Pro Gln Leu Ala  Thr Met Arg Gln Leu  Ser Asp Ala 
    1025                 1030                 1035             


Asp Lys  Leu Arg Lys Val Ile  Cys Glu Leu Leu Glu  Thr Glu Arg 
    1040                 1045                 1050             


Thr Tyr  Val Lys Asp Leu Asn  Cys Leu Met Glu Arg  Tyr Leu Lys 
    1055                 1060                 1065             


Pro Leu  Gln Lys Glu Thr Phe  Leu Thr Gln Asp Glu  Leu Asp Val 
    1070                 1075                 1080             


Leu Phe  Gly Asn Leu Thr Glu  Met Val Glu Phe Gln  Val Glu Phe 
    1085                 1090                 1095             


Leu Lys  Thr Leu Glu Asp Gly  Val Arg Leu Val Pro  Asp Leu Glu 
    1100                 1105                 1110             


Lys Leu  Glu Lys Val Asp Gln  Phe Lys Lys Val Leu  Phe Ser Leu 
    1115                 1120                 1125             


Gly Gly  Ser Phe Leu Tyr Tyr  Ala Asp Arg Phe Lys  Leu Tyr Ser 
    1130                 1135                 1140             


Ala Phe  Cys Ala Ser His Thr  Lys Val Pro Lys Val  Leu Val Lys 
    1145                 1150                 1155             


Ala Lys  Thr Asp Thr Ala Phe  Lys Ala Phe Leu Asp  Ala Gln Asn 
    1160                 1165                 1170             


Pro Lys  Gln Gln His Ser Ser  Thr Leu Glu Ser Tyr  Leu Ile Lys 
    1175                 1180                 1185             


Pro Ile  Gln Arg Ile Leu Lys  Tyr Pro Leu Leu Leu  Arg Glu Leu 
    1190                 1195                 1200             


Phe Ala  Leu Thr Asp Ala Glu  Ser Glu Glu His Tyr  His Leu Asp 
    1205                 1210                 1215             


Val Ala  Ile Lys Thr Met Asn  Lys Val Ala Ser His  Ile Asn Glu 
    1220                 1225                 1230             


Met Gln  Lys Ile His Glu Glu  Phe Gly Ala Val Phe  Asp Gln Leu 
    1235                 1240                 1245             


Ile Ala  Glu Gln Thr Gly Glu  Lys Lys Glu Val Ala  Asp Leu Ser 
    1250                 1255                 1260             


Met Gly  Asp Leu Leu Leu His  Thr Thr Val Ile Trp  Leu Asn Pro 
    1265                 1270                 1275             


Pro Ala  Ser Leu Gly Lys Trp  Lys Lys Glu Pro Glu  Leu Ala Ala 
    1280                 1285                 1290             


Phe Val  Phe Lys Thr Ala Val  Val Leu Val Tyr Lys  Asp Gly Ser 
    1295                 1300                 1305             


Lys Gln  Lys Lys Lys Leu Val  Gly Ser His Arg Leu  Ser Ile Tyr 
    1310                 1315                 1320             


Glu Asp  Trp Asp Pro Phe Arg  Phe Arg His Met Ile  Pro Thr Glu 
    1325                 1330                 1335             


Ala Leu  Gln Val Arg Ala Leu  Ala Ser Ala Asp Ala  Glu Ala Asn 
    1340                 1345                 1350             


Ala Val  Cys Glu Ile Val His  Val Lys Ser Glu Ser  Glu Gly Arg 
    1355                 1360                 1365             


Pro Glu  Arg Val Phe His Leu  Cys Cys Ser Ser Pro  Glu Ser Arg 
    1370                 1375                 1380             


Lys Asp  Phe Leu Lys Ala Val  His Ser Ile Leu Arg  Asp Lys His 
    1385                 1390                 1395             


Arg Arg  Gln Leu Leu Lys Thr  Glu Ser Leu Pro Ser  Ser Gln Gln 
    1400                 1405                 1410             


Tyr Val  Pro Phe Gly Gly Lys  Arg Leu Cys Ala Leu  Lys Gly Ala 
    1415                 1420                 1425             


Arg Pro  Ala Met Ser Arg Ala  Val Ser Ala Pro Ser  Lys Ser Leu 
    1430                 1435                 1440             


Gly Arg  Arg Arg Arg Arg Leu  Ala Arg Asn Arg Phe  Thr Ile Asp 
    1445                 1450                 1455             


Ser Asp  Ala Val Ser Ala Ser  Ser Pro Glu Lys Glu  Ser Gln Gln 
    1460                 1465                 1470             


Pro Pro  Gly Gly Gly Asp Thr  Asp Arg Trp Val Glu  Glu Gln Phe 
    1475                 1480                 1485             


Asp Leu  Ala Gln Tyr Glu Glu  Gln Asp Asp Ile Lys  Glu Thr Asp 
    1490                 1495                 1500             


Ile Leu  Ser Asp Asp Asp Glu  Phe Cys Glu Ser Val  Lys Gly Ala 
    1505                 1510                 1515             


Ser Val  Asp Arg Asp Leu Gln  Glu Arg Leu Gln Ala  Thr Ser Ile 
    1520                 1525                 1530             


Ser Gln  Arg Glu Arg Gly Arg  Lys Thr Leu Asp Ser  His Ala Ser 
    1535                 1540                 1545             


Arg Met  Ala Gln Leu Lys Lys  Gln Ala Ala Leu Ser  Gly Ile Asn 
    1550                 1555                 1560             


Gly Gly  Leu Glu Ser Ala Ser  Glu Glu Val Ile Trp  Val Arg Arg 
    1565                 1570                 1575             


Glu Asp  Phe Ala Pro Ser Arg  Lys Leu Asn Thr Glu  Ile 
    1580                 1585                 1590     


<210>  10
<211>  882
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P12830
<309>  2016-09-07
<313>  (1)..(882)

<400>  10

Met Gly Pro Trp Ser Arg Ser Leu Ser Ala Leu Leu Leu Leu Leu Gln 
1               5                   10                  15      


Val Ser Ser Trp Leu Cys Gln Glu Pro Glu Pro Cys His Pro Gly Phe 
            20                  25                  30          


Asp Ala Glu Ser Tyr Thr Phe Thr Val Pro Arg Arg His Leu Glu Arg 
        35                  40                  45              


Gly Arg Val Leu Gly Arg Val Asn Phe Glu Asp Cys Thr Gly Arg Gln 
    50                  55                  60                  


Arg Thr Ala Tyr Phe Ser Leu Asp Thr Arg Phe Lys Val Gly Thr Asp 
65                  70                  75                  80  


Gly Val Ile Thr Val Lys Arg Pro Leu Arg Phe His Asn Pro Gln Ile 
                85                  90                  95      


His Phe Leu Val Tyr Ala Trp Asp Ser Thr Tyr Arg Lys Phe Ser Thr 
            100                 105                 110         


Lys Val Thr Leu Asn Thr Val Gly His His His Arg Pro Pro Pro His 
        115                 120                 125             


Gln Ala Ser Val Ser Gly Ile Gln Ala Glu Leu Leu Thr Phe Pro Asn 
    130                 135                 140                 


Ser Ser Pro Gly Leu Arg Arg Gln Lys Arg Asp Trp Val Ile Pro Pro 
145                 150                 155                 160 


Ile Ser Cys Pro Glu Asn Glu Lys Gly Pro Phe Pro Lys Asn Leu Val 
                165                 170                 175     


Gln Ile Lys Ser Asn Lys Asp Lys Glu Gly Lys Val Phe Tyr Ser Ile 
            180                 185                 190         


Thr Gly Gln Gly Ala Asp Thr Pro Pro Val Gly Val Phe Ile Ile Glu 
        195                 200                 205             


Arg Glu Thr Gly Trp Leu Lys Val Thr Glu Pro Leu Asp Arg Glu Arg 
    210                 215                 220                 


Ile Ala Thr Tyr Thr Leu Phe Ser His Ala Val Ser Ser Asn Gly Asn 
225                 230                 235                 240 


Ala Val Glu Asp Pro Met Glu Ile Leu Ile Thr Val Thr Asp Gln Asn 
                245                 250                 255     


Asp Asn Lys Pro Glu Phe Thr Gln Glu Val Phe Lys Gly Ser Val Met 
            260                 265                 270         


Glu Gly Ala Leu Pro Gly Thr Ser Val Met Glu Val Thr Ala Thr Asp 
        275                 280                 285             


Ala Asp Asp Asp Val Asn Thr Tyr Asn Ala Ala Ile Ala Tyr Thr Ile 
    290                 295                 300                 


Leu Ser Gln Asp Pro Glu Leu Pro Asp Lys Asn Met Phe Thr Ile Asn 
305                 310                 315                 320 


Arg Asn Thr Gly Val Ile Ser Val Val Thr Thr Gly Leu Asp Arg Glu 
                325                 330                 335     


Ser Phe Pro Thr Tyr Thr Leu Val Val Gln Ala Ala Asp Leu Gln Gly 
            340                 345                 350         


Glu Gly Leu Ser Thr Thr Ala Thr Ala Val Ile Thr Val Thr Asp Thr 
        355                 360                 365             


Asn Asp Asn Pro Pro Ile Phe Asn Pro Thr Thr Tyr Lys Gly Gln Val 
    370                 375                 380                 


Pro Glu Asn Glu Ala Asn Val Val Ile Thr Thr Leu Lys Val Thr Asp 
385                 390                 395                 400 


Ala Asp Ala Pro Asn Thr Pro Ala Trp Glu Ala Val Tyr Thr Ile Leu 
                405                 410                 415     


Asn Asp Asp Gly Gly Gln Phe Val Val Thr Thr Asn Pro Val Asn Asn 
            420                 425                 430         


Asp Gly Ile Leu Lys Thr Ala Lys Gly Leu Asp Phe Glu Ala Lys Gln 
        435                 440                 445             


Gln Tyr Ile Leu His Val Ala Val Thr Asn Val Val Pro Phe Glu Val 
    450                 455                 460                 


Ser Leu Thr Thr Ser Thr Ala Thr Val Thr Val Asp Val Leu Asp Val 
465                 470                 475                 480 


Asn Glu Ala Pro Ile Phe Val Pro Pro Glu Lys Arg Val Glu Val Ser 
                485                 490                 495     


Glu Asp Phe Gly Val Gly Gln Glu Ile Thr Ser Tyr Thr Ala Gln Glu 
            500                 505                 510         


Pro Asp Thr Phe Met Glu Gln Lys Ile Thr Tyr Arg Ile Trp Arg Asp 
        515                 520                 525             


Thr Ala Asn Trp Leu Glu Ile Asn Pro Asp Thr Gly Ala Ile Ser Thr 
    530                 535                 540                 


Arg Ala Glu Leu Asp Arg Glu Asp Phe Glu His Val Lys Asn Ser Thr 
545                 550                 555                 560 


Tyr Thr Ala Leu Ile Ile Ala Thr Asp Asn Gly Ser Pro Val Ala Thr 
                565                 570                 575     


Gly Thr Gly Thr Leu Leu Leu Ile Leu Ser Asp Val Asn Asp Asn Ala 
            580                 585                 590         


Pro Ile Pro Glu Pro Arg Thr Ile Phe Phe Cys Glu Arg Asn Pro Lys 
        595                 600                 605             


Pro Gln Val Ile Asn Ile Ile Asp Ala Asp Leu Pro Pro Asn Thr Ser 
    610                 615                 620                 


Pro Phe Thr Ala Glu Leu Thr His Gly Ala Ser Ala Asn Trp Thr Ile 
625                 630                 635                 640 


Gln Tyr Asn Asp Pro Thr Gln Glu Ser Ile Ile Leu Lys Pro Lys Met 
                645                 650                 655     


Ala Leu Glu Val Gly Asp Tyr Lys Ile Asn Leu Lys Leu Met Asp Asn 
            660                 665                 670         


Gln Asn Lys Asp Gln Val Thr Thr Leu Glu Val Ser Val Cys Asp Cys 
        675                 680                 685             


Glu Gly Ala Ala Gly Val Cys Arg Lys Ala Gln Pro Val Glu Ala Gly 
    690                 695                 700                 


Leu Gln Ile Pro Ala Ile Leu Gly Ile Leu Gly Gly Ile Leu Ala Leu 
705                 710                 715                 720 


Leu Ile Leu Ile Leu Leu Leu Leu Leu Phe Leu Arg Arg Arg Ala Val 
                725                 730                 735     


Val Lys Glu Pro Leu Leu Pro Pro Glu Asp Asp Thr Arg Asp Asn Val 
            740                 745                 750         


Tyr Tyr Tyr Asp Glu Glu Gly Gly Gly Glu Glu Asp Gln Asp Phe Asp 
        755                 760                 765             


Leu Ser Gln Leu His Arg Gly Leu Asp Ala Arg Pro Glu Val Thr Arg 
    770                 775                 780                 


Asn Asp Val Ala Pro Thr Leu Met Ser Val Pro Arg Tyr Leu Pro Arg 
785                 790                 795                 800 


Pro Ala Asn Pro Asp Glu Ile Gly Asn Phe Ile Asp Glu Asn Leu Lys 
                805                 810                 815     


Ala Ala Asp Thr Asp Pro Thr Ala Pro Pro Tyr Asp Ser Leu Leu Val 
            820                 825                 830         


Phe Asp Tyr Glu Gly Ser Gly Ser Glu Ala Ala Ser Leu Ser Ser Leu 
        835                 840                 845             


Asn Ser Ser Glu Ser Asp Lys Asp Gln Asp Tyr Asp Tyr Leu Asn Glu 
    850                 855                 860                 


Trp Gly Asn Arg Phe Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu 
865                 870                 875                 880 


Asp Asp 
        


<210>  11
<211>  699
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9P2Y5
<309>  2016-09-07
<313>  (1)..(699)

<400>  11

Met Ser Ala Ser Ala Ser Val Gly Gly Pro Val Pro Gln Pro Pro Pro 
1               5                   10                  15      


Gly Pro Ala Ala Ala Leu Pro Pro Gly Ser Ala Ala Arg Ala Leu His 
            20                  25                  30          


Val Glu Leu Pro Ser Gln Gln Arg Arg Leu Arg His Leu Arg Asn Ile 
        35                  40                  45              


Ala Ala Arg Asn Ile Val Asn Arg Asn Gly His Gln Leu Leu Asp Thr 
    50                  55                  60                  


Tyr Phe Thr Leu His Leu Cys Ser Thr Glu Lys Ile Tyr Lys Glu Phe 
65                  70                  75                  80  


Tyr Arg Ser Glu Val Ile Lys Asn Ser Leu Asn Pro Thr Trp Arg Ser 
                85                  90                  95      


Leu Asp Phe Gly Ile Met Pro Asp Arg Leu Asp Thr Ser Val Ser Cys 
            100                 105                 110         


Phe Val Val Lys Ile Trp Gly Gly Lys Glu Asn Ile Tyr Gln Leu Leu 
        115                 120                 125             


Ile Glu Trp Lys Val Cys Leu Asp Gly Leu Lys Tyr Leu Gly Gln Gln 
    130                 135                 140                 


Ile His Ala Arg Asn Gln Asn Glu Ile Ile Phe Gly Leu Asn Asp Gly 
145                 150                 155                 160 


Tyr Tyr Gly Ala Pro Phe Glu His Lys Gly Tyr Ser Asn Ala Gln Lys 
                165                 170                 175     


Thr Ile Leu Leu Gln Val Asp Gln Asn Cys Val Arg Asn Ser Tyr Asp 
            180                 185                 190         


Val Phe Ser Leu Leu Arg Leu His Arg Ala Gln Cys Ala Ile Lys Gln 
        195                 200                 205             


Thr Gln Val Thr Val Gln Lys Ile Gly Lys Glu Ile Glu Glu Lys Leu 
    210                 215                 220                 


Arg Leu Thr Ser Thr Ser Asn Glu Leu Lys Lys Lys Ser Glu Cys Leu 
225                 230                 235                 240 


Gln Leu Lys Ile Leu Val Leu Gln Asn Glu Leu Glu Arg Gln Lys Lys 
                245                 250                 255     


Ala Leu Gly Arg Glu Val Ala Leu Leu His Lys Gln Gln Ile Ala Leu 
            260                 265                 270         


Gln Asp Lys Gly Ser Ala Phe Ser Ala Glu His Leu Lys Leu Gln Leu 
        275                 280                 285             


Gln Lys Glu Ser Leu Asn Glu Leu Arg Lys Glu Cys Thr Ala Lys Arg 
    290                 295                 300                 


Glu Leu Phe Leu Lys Thr Asn Ala Gln Leu Thr Ile Arg Cys Arg Gln 
305                 310                 315                 320 


Leu Leu Ser Glu Leu Ser Tyr Ile Tyr Pro Ile Asp Leu Asn Glu His 
                325                 330                 335     


Lys Asp Tyr Phe Val Cys Gly Val Lys Leu Pro Asn Ser Glu Asp Phe 
            340                 345                 350         


Gln Ala Lys Asp Asp Gly Ser Ile Ala Val Ala Leu Gly Tyr Thr Ala 
        355                 360                 365             


His Leu Val Ser Met Ile Ser Phe Phe Leu Gln Val Pro Leu Arg Tyr 
    370                 375                 380                 


Pro Ile Ile His Lys Gly Ser Arg Ser Thr Ile Lys Asp Asn Ile Asn 
385                 390                 395                 400 


Asp Lys Leu Thr Glu Lys Glu Arg Glu Phe Pro Leu Tyr Pro Lys Gly 
                405                 410                 415     


Gly Glu Lys Leu Gln Phe Asp Tyr Gly Val Tyr Leu Leu Asn Lys Asn 
            420                 425                 430         


Ile Ala Gln Leu Arg Tyr Gln His Gly Leu Gly Thr Pro Asp Leu Arg 
        435                 440                 445             


Gln Thr Leu Pro Asn Leu Lys Asn Phe Met Glu His Gly Leu Met Val 
    450                 455                 460                 


Arg Cys Asp Arg His His Thr Ser Ser Ala Ile Pro Val Pro Lys Arg 
465                 470                 475                 480 


Gln Ser Ser Ile Phe Gly Gly Ala Asp Val Gly Phe Ser Gly Gly Ile 
                485                 490                 495     


Pro Ser Pro Asp Lys Gly His Arg Lys Arg Ala Ser Ser Glu Asn Glu 
            500                 505                 510         


Arg Leu Gln Tyr Lys Thr Pro Pro Pro Ser Tyr Asn Ser Ala Leu Ala 
        515                 520                 525             


Gln Pro Val Thr Thr Val Pro Ser Met Gly Glu Thr Glu Arg Lys Ile 
    530                 535                 540                 


Thr Ser Leu Ser Ser Ser Leu Asp Thr Ser Leu Asp Phe Ser Lys Glu 
545                 550                 555                 560 


Asn Lys Lys Lys Gly Glu Asp Leu Val Gly Ser Leu Asn Gly Gly His 
                565                 570                 575     


Ala Asn Val His Pro Ser Gln Glu Gln Gly Glu Ala Leu Ser Gly His 
            580                 585                 590         


Arg Ala Thr Val Asn Gly Thr Leu Leu Pro Ser Glu Gln Ala Gly Ser 
        595                 600                 605             


Ala Ser Val Gln Leu Pro Gly Glu Phe His Pro Val Ser Glu Ala Glu 
    610                 615                 620                 


Leu Cys Cys Thr Val Glu Gln Ala Glu Glu Ile Ile Gly Leu Glu Ala 
625                 630                 635                 640 


Thr Gly Phe Ala Ser Gly Asp Gln Leu Glu Ala Phe Asn Cys Ile Pro 
                645                 650                 655     


Val Asp Ser Ala Val Ala Val Glu Cys Asp Glu Gln Val Leu Gly Glu 
            660                 665                 670         


Phe Glu Glu Phe Ser Arg Arg Ile Tyr Ala Leu Asn Glu Asn Val Ser 
        675                 680                 685             


Ser Phe Arg Arg Pro Arg Arg Ser Ser Asp Lys 
    690                 695                 


<210>  12
<211>  559
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q13131
<309>  2016-09-07
<313>  (1)..(559)

<400>  12

Met Arg Arg Leu Ser Ser Trp Arg Lys Met Ala Thr Ala Glu Lys Gln 
1               5                   10                  15      


Lys His Asp Gly Arg Val Lys Ile Gly His Tyr Ile Leu Gly Asp Thr 
            20                  25                  30          


Leu Gly Val Gly Thr Phe Gly Lys Val Lys Val Gly Lys His Glu Leu 
        35                  40                  45              


Thr Gly His Lys Val Ala Val Lys Ile Leu Asn Arg Gln Lys Ile Arg 
    50                  55                  60                  


Ser Leu Asp Val Val Gly Lys Ile Arg Arg Glu Ile Gln Asn Leu Lys 
65                  70                  75                  80  


Leu Phe Arg His Pro His Ile Ile Lys Leu Tyr Gln Val Ile Ser Thr 
                85                  90                  95      


Pro Ser Asp Ile Phe Met Val Met Glu Tyr Val Ser Gly Gly Glu Leu 
            100                 105                 110         


Phe Asp Tyr Ile Cys Lys Asn Gly Arg Leu Asp Glu Lys Glu Ser Arg 
        115                 120                 125             


Arg Leu Phe Gln Gln Ile Leu Ser Gly Val Asp Tyr Cys His Arg His 
    130                 135                 140                 


Met Val Val His Arg Asp Leu Lys Pro Glu Asn Val Leu Leu Asp Ala 
145                 150                 155                 160 


His Met Asn Ala Lys Ile Ala Asp Phe Gly Leu Ser Asn Met Met Ser 
                165                 170                 175     


Asp Gly Glu Phe Leu Arg Thr Ser Cys Gly Ser Pro Asn Tyr Ala Ala 
            180                 185                 190         


Pro Glu Val Ile Ser Gly Arg Leu Tyr Ala Gly Pro Glu Val Asp Ile 
        195                 200                 205             


Trp Ser Ser Gly Val Ile Leu Tyr Ala Leu Leu Cys Gly Thr Leu Pro 
    210                 215                 220                 


Phe Asp Asp Asp His Val Pro Thr Leu Phe Lys Lys Ile Cys Asp Gly 
225                 230                 235                 240 


Ile Phe Tyr Thr Pro Gln Tyr Leu Asn Pro Ser Val Ile Ser Leu Leu 
                245                 250                 255     


Lys His Met Leu Gln Val Asp Pro Met Lys Arg Ala Thr Ile Lys Asp 
            260                 265                 270         


Ile Arg Glu His Glu Trp Phe Lys Gln Asp Leu Pro Lys Tyr Leu Phe 
        275                 280                 285             


Pro Glu Asp Pro Ser Tyr Ser Ser Thr Met Ile Asp Asp Glu Ala Leu 
    290                 295                 300                 


Lys Glu Val Cys Glu Lys Phe Glu Cys Ser Glu Glu Glu Val Leu Ser 
305                 310                 315                 320 


Cys Leu Tyr Asn Arg Asn His Gln Asp Pro Leu Ala Val Ala Tyr His 
                325                 330                 335     


Leu Ile Ile Asp Asn Arg Arg Ile Met Asn Glu Ala Lys Asp Phe Tyr 
            340                 345                 350         


Leu Ala Thr Ser Pro Pro Asp Ser Phe Leu Asp Asp His His Leu Thr 
        355                 360                 365             


Arg Pro His Pro Glu Arg Val Pro Phe Leu Val Ala Glu Thr Pro Arg 
    370                 375                 380                 


Ala Arg His Thr Leu Asp Glu Leu Asn Pro Gln Lys Ser Lys His Gln 
385                 390                 395                 400 


Gly Val Arg Lys Ala Lys Trp His Leu Gly Ile Arg Ser Gln Ser Arg 
                405                 410                 415     


Pro Asn Asp Ile Met Ala Glu Val Cys Arg Ala Ile Lys Gln Leu Asp 
            420                 425                 430         


Tyr Glu Trp Lys Val Val Asn Pro Tyr Tyr Leu Arg Val Arg Arg Lys 
        435                 440                 445             


Asn Pro Val Thr Ser Thr Tyr Ser Lys Met Ser Leu Gln Leu Tyr Gln 
    450                 455                 460                 


Val Asp Ser Arg Thr Tyr Leu Leu Asp Phe Arg Ser Ile Asp Asp Glu 
465                 470                 475                 480 


Ile Thr Glu Ala Lys Ser Gly Thr Ala Thr Pro Gln Arg Ser Gly Ser 
                485                 490                 495     


Val Ser Asn Tyr Arg Ser Cys Gln Arg Ser Asp Ser Asp Ala Glu Ala 
            500                 505                 510         


Gln Gly Lys Ser Ser Glu Val Ser Leu Thr Ser Ser Val Thr Ser Leu 
        515                 520                 525             


Asp Ser Ser Pro Val Asp Leu Thr Pro Arg Pro Gly Ser His Thr Ile 
    530                 535                 540                 


Glu Phe Phe Glu Met Cys Ala Asn Leu Ile Lys Ile Leu Ala Gln 
545                 550                 555                 


<210>  13
<211>  740
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9UER7
<309>  2016-09-07
<313>  (1)..(740)

<400>  13

Met Ala Thr Ala Asn Ser Ile Ile Val Leu Asp Asp Asp Asp Glu Asp 
1               5                   10                  15      


Glu Ala Ala Ala Gln Pro Gly Pro Ser His Pro Leu Pro Asn Ala Ala 
            20                  25                  30          


Ser Pro Gly Ala Glu Ala Pro Ser Ser Ser Glu Pro His Gly Ala Arg 
        35                  40                  45              


Gly Ser Ser Ser Ser Gly Gly Lys Lys Cys Tyr Lys Leu Glu Asn Glu 
    50                  55                  60                  


Lys Leu Phe Glu Glu Phe Leu Glu Leu Cys Lys Met Gln Thr Ala Asp 
65                  70                  75                  80  


His Pro Glu Val Val Pro Phe Leu Tyr Asn Arg Gln Gln Arg Ala His 
                85                  90                  95      


Ser Leu Phe Leu Ala Ser Ala Glu Phe Cys Asn Ile Leu Ser Arg Val 
            100                 105                 110         


Leu Ser Arg Ala Arg Ser Arg Pro Ala Lys Leu Tyr Val Tyr Ile Asn 
        115                 120                 125             


Glu Leu Cys Thr Val Leu Lys Ala His Ser Ala Lys Lys Lys Leu Asn 
    130                 135                 140                 


Leu Ala Pro Ala Ala Thr Thr Ser Asn Glu Pro Ser Gly Asn Asn Pro 
145                 150                 155                 160 


Pro Thr His Leu Ser Leu Asp Pro Thr Asn Ala Glu Asn Thr Ala Ser 
                165                 170                 175     


Gln Ser Pro Arg Thr Arg Gly Ser Arg Arg Gln Ile Gln Arg Leu Glu 
            180                 185                 190         


Gln Leu Leu Ala Leu Tyr Val Ala Glu Ile Arg Arg Leu Gln Glu Lys 
        195                 200                 205             


Glu Leu Asp Leu Ser Glu Leu Asp Asp Pro Asp Ser Ala Tyr Leu Gln 
    210                 215                 220                 


Glu Ala Arg Leu Lys Arg Lys Leu Ile Arg Leu Phe Gly Arg Leu Cys 
225                 230                 235                 240 


Glu Leu Lys Asp Cys Ser Ser Leu Thr Gly Arg Val Ile Glu Gln Arg 
                245                 250                 255     


Ile Pro Tyr Arg Gly Thr Arg Tyr Pro Glu Val Asn Arg Arg Ile Glu 
            260                 265                 270         


Arg Leu Ile Asn Lys Pro Gly Pro Asp Thr Phe Pro Asp Tyr Gly Asp 
        275                 280                 285             


Val Leu Arg Ala Val Glu Lys Ala Ala Ala Arg His Ser Leu Gly Leu 
    290                 295                 300                 


Pro Arg Gln Gln Leu Gln Leu Met Ala Gln Asp Ala Phe Arg Asp Val 
305                 310                 315                 320 


Gly Ile Arg Leu Gln Glu Arg Arg His Leu Asp Leu Ile Tyr Asn Phe 
                325                 330                 335     


Gly Cys His Leu Thr Asp Asp Tyr Arg Pro Gly Val Asp Pro Ala Leu 
            340                 345                 350         


Ser Asp Pro Val Leu Ala Arg Arg Leu Arg Glu Asn Arg Ser Leu Ala 
        355                 360                 365             


Met Ser Arg Leu Asp Glu Val Ile Ser Lys Tyr Ala Met Leu Gln Asp 
    370                 375                 380                 


Lys Ser Glu Glu Gly Glu Arg Lys Lys Arg Arg Ala Arg Leu Gln Gly 
385                 390                 395                 400 


Thr Ser Ser His Ser Ala Asp Thr Pro Glu Ala Ser Leu Asp Ser Gly 
                405                 410                 415     


Glu Gly Pro Ser Gly Met Ala Ser Gln Gly Cys Pro Ser Ala Ser Arg 
            420                 425                 430         


Ala Glu Thr Asp Asp Glu Asp Asp Glu Glu Ser Asp Glu Glu Glu Glu 
        435                 440                 445             


Glu Glu Glu Glu Glu Glu Glu Glu Glu Ala Thr Asp Ser Glu Glu Glu 
    450                 455                 460                 


Glu Asp Leu Glu Gln Met Gln Glu Gly Gln Glu Asp Asp Glu Glu Glu 
465                 470                 475                 480 


Asp Glu Glu Glu Glu Ala Ala Ala Gly Lys Asp Gly Asp Lys Ser Pro 
                485                 490                 495     


Met Ser Ser Leu Gln Ile Ser Asn Glu Lys Asn Leu Glu Pro Gly Lys 
            500                 505                 510         


Gln Ile Ser Arg Ser Ser Gly Glu Gln Gln Asn Lys Gly Arg Ile Val 
        515                 520                 525             


Ser Pro Ser Leu Leu Ser Glu Glu Pro Leu Ala Pro Ser Ser Ile Asp 
    530                 535                 540                 


Ala Glu Ser Asn Gly Glu Gln Pro Glu Glu Leu Thr Leu Glu Glu Glu 
545                 550                 555                 560 


Ser Pro Val Ser Gln Leu Phe Glu Leu Glu Ile Glu Ala Leu Pro Leu 
                565                 570                 575     


Asp Thr Pro Ser Ser Val Glu Thr Asp Ile Ser Ser Ser Arg Lys Gln 
            580                 585                 590         


Ser Glu Glu Pro Phe Thr Thr Val Leu Glu Asn Gly Ala Gly Met Val 
        595                 600                 605             


Ser Ser Thr Ser Phe Asn Gly Gly Val Ser Pro His Asn Trp Gly Asp 
    610                 615                 620                 


Ser Gly Pro Pro Cys Lys Lys Ser Arg Lys Glu Lys Lys Gln Thr Gly 
625                 630                 635                 640 


Ser Gly Pro Leu Gly Asn Ser Tyr Val Glu Arg Gln Arg Ser Val His 
                645                 650                 655     


Glu Lys Asn Gly Lys Lys Ile Cys Thr Leu Pro Ser Pro Pro Ser Pro 
            660                 665                 670         


Leu Ala Ser Leu Ala Pro Val Ala Asp Ser Ser Thr Arg Val Asp Ser 
        675                 680                 685             


Pro Ser His Gly Leu Val Thr Ser Ser Leu Cys Ile Pro Ser Pro Ala 
    690                 695                 700                 


Arg Leu Ser Gln Thr Pro His Ser Gln Pro Pro Arg Pro Gly Thr Cys 
705                 710                 715                 720 


Lys Thr Ser Val Ala Thr Gln Cys Asp Pro Glu Glu Ile Ile Val Leu 
                725                 730                 735     


Ser Asp Ser Asp 
            740 


<210>  14
<211>  419
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt /O14929
<309>  2016-09-07
<313>  (1)..(419)

<400>  14

Met Ala Gly Phe Gly Ala Met Glu Lys Phe Leu Val Glu Tyr Lys Ser 
1               5                   10                  15      


Ala Val Glu Lys Lys Leu Ala Glu Tyr Lys Cys Asn Thr Asn Thr Ala 
            20                  25                  30          


Ile Glu Leu Lys Leu Val Arg Phe Pro Glu Asp Leu Glu Asn Asp Ile 
        35                  40                  45              


Arg Thr Phe Phe Pro Glu Tyr Thr His Gln Leu Phe Gly Asp Asp Glu 
    50                  55                  60                  


Thr Ala Phe Gly Tyr Lys Gly Leu Lys Ile Leu Leu Tyr Tyr Ile Ala 
65                  70                  75                  80  


Gly Ser Leu Ser Thr Met Phe Arg Val Glu Tyr Ala Ser Lys Val Asp 
                85                  90                  95      


Glu Asn Phe Asp Cys Val Glu Ala Asp Asp Val Glu Gly Lys Ile Arg 
            100                 105                 110         


Gln Ile Ile Pro Pro Gly Phe Cys Thr Asn Thr Asn Asp Phe Leu Ser 
        115                 120                 125             


Leu Leu Glu Lys Glu Val Asp Phe Lys Pro Phe Gly Thr Leu Leu His 
    130                 135                 140                 


Thr Tyr Ser Val Leu Ser Pro Thr Gly Gly Glu Asn Phe Thr Phe Gln 
145                 150                 155                 160 


Ile Tyr Lys Ala Asp Met Thr Cys Arg Gly Phe Arg Glu Tyr His Glu 
                165                 170                 175     


Arg Leu Gln Thr Phe Leu Met Trp Phe Ile Glu Thr Ala Ser Phe Ile 
            180                 185                 190         


Asp Val Asp Asp Glu Arg Trp His Tyr Phe Leu Val Phe Glu Lys Tyr 
        195                 200                 205             


Asn Lys Asp Gly Ala Thr Leu Phe Ala Thr Val Gly Tyr Met Thr Val 
    210                 215                 220                 


Tyr Asn Tyr Tyr Val Tyr Pro Asp Lys Thr Arg Pro Arg Val Ser Gln 
225                 230                 235                 240 


Met Leu Ile Leu Thr Pro Phe Gln Gly Gln Gly His Gly Ala Gln Leu 
                245                 250                 255     


Leu Glu Thr Val His Arg Tyr Tyr Thr Glu Phe Pro Thr Val Leu Asp 
            260                 265                 270         


Ile Thr Ala Glu Asp Pro Ser Lys Ser Tyr Val Lys Leu Arg Asp Phe 
        275                 280                 285             


Val Leu Val Lys Leu Cys Gln Asp Leu Pro Cys Phe Ser Arg Glu Lys 
    290                 295                 300                 


Leu Met Gln Gly Phe Asn Glu Asp Met Ala Ile Glu Ala Gln Gln Lys 
305                 310                 315                 320 


Phe Lys Ile Asn Lys Gln His Ala Arg Arg Val Tyr Glu Ile Leu Arg 
                325                 330                 335     


Leu Leu Val Thr Asp Met Ser Asp Ala Glu Gln Tyr Arg Ser Tyr Arg 
            340                 345                 350         


Leu Asp Ile Lys Arg Arg Leu Ile Ser Pro Tyr Lys Lys Lys Gln Arg 
        355                 360                 365             


Asp Leu Ala Lys Met Arg Lys Cys Leu Arg Pro Glu Glu Leu Thr Asn 
    370                 375                 380                 


Gln Met Asn Gln Ile Glu Ile Ser Met Gln His Glu Gln Leu Glu Glu 
385                 390                 395                 400 


Ser Phe Gln Glu Leu Val Glu Asp Tyr Arg Arg Val Ile Glu Arg Leu 
                405                 410                 415     


Ala Gln Glu 
            


<210>  15
<211>  297
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P06493
<309>  2016-09-07
<313>  (1)..(297)

<400>  15

Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met 
            20                  25                  30          


Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 
    50                  55                  60                  


Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 
65                  70                  75                  80  


Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 
                85                  90                  95      


Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile 
            100                 105                 110         


Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 
        115                 120                 125             


Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 
    130                 135                 140                 


Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 
145                 150                 155                 160 


Thr His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 
                165                 170                 175     


Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr 
            180                 185                 190         


Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser 
        195                 200                 205             


Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn 
    210                 215                 220                 


Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr 
225                 230                 235                 240 


Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu 
                245                 250                 255     


Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Ile Tyr Asp Pro 
            260                 265                 270         


Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Asn His Pro Tyr Phe Asn 
        275                 280                 285             


Asp Leu Asp Asn Gln Ile Lys Lys Met 
    290                 295         


<210>  16
<211>  488
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q92769
<309>  2016-09-07
<313>  (1)..(488)

<400>  16

Met Ala Tyr Ser Gln Gly Gly Gly Lys Lys Lys Val Cys Tyr Tyr Tyr 
1               5                   10                  15      


Asp Gly Asp Ile Gly Asn Tyr Tyr Tyr Gly Gln Gly His Pro Met Lys 
            20                  25                  30          


Pro His Arg Ile Arg Met Thr His Asn Leu Leu Leu Asn Tyr Gly Leu 
        35                  40                  45              


Tyr Arg Lys Met Glu Ile Tyr Arg Pro His Lys Ala Thr Ala Glu Glu 
    50                  55                  60                  


Met Thr Lys Tyr His Ser Asp Glu Tyr Ile Lys Phe Leu Arg Ser Ile 
65                  70                  75                  80  


Arg Pro Asp Asn Met Ser Glu Tyr Ser Lys Gln Met Gln Arg Phe Asn 
                85                  90                  95      


Val Gly Glu Asp Cys Pro Val Phe Asp Gly Leu Phe Glu Phe Cys Gln 
            100                 105                 110         


Leu Ser Thr Gly Gly Ser Val Ala Gly Ala Val Lys Leu Asn Arg Gln 
        115                 120                 125             


Gln Thr Asp Met Ala Val Asn Trp Ala Gly Gly Leu His His Ala Lys 
    130                 135                 140                 


Lys Ser Glu Ala Ser Gly Phe Cys Tyr Val Asn Asp Ile Val Leu Ala 
145                 150                 155                 160 


Ile Leu Glu Leu Leu Lys Tyr His Gln Arg Val Leu Tyr Ile Asp Ile 
                165                 170                 175     


Asp Ile His His Gly Asp Gly Val Glu Glu Ala Phe Tyr Thr Thr Asp 
            180                 185                 190         


Arg Val Met Thr Val Ser Phe His Lys Tyr Gly Glu Tyr Phe Pro Gly 
        195                 200                 205             


Thr Gly Asp Leu Arg Asp Ile Gly Ala Gly Lys Gly Lys Tyr Tyr Ala 
    210                 215                 220                 


Val Asn Phe Pro Met Arg Asp Gly Ile Asp Asp Glu Ser Tyr Gly Gln 
225                 230                 235                 240 


Ile Phe Lys Pro Ile Ile Ser Lys Val Met Glu Met Tyr Gln Pro Ser 
                245                 250                 255     


Ala Val Val Leu Gln Cys Gly Ala Asp Ser Leu Ser Gly Asp Arg Leu 
            260                 265                 270         


Gly Cys Phe Asn Leu Thr Val Lys Gly His Ala Lys Cys Val Glu Val 
        275                 280                 285             


Val Lys Thr Phe Asn Leu Pro Leu Leu Met Leu Gly Gly Gly Gly Tyr 
    290                 295                 300                 


Thr Ile Arg Asn Val Ala Arg Cys Trp Thr Tyr Glu Thr Ala Val Ala 
305                 310                 315                 320 


Leu Asp Cys Glu Ile Pro Asn Glu Leu Pro Tyr Asn Asp Tyr Phe Glu 
                325                 330                 335     


Tyr Phe Gly Pro Asp Phe Lys Leu His Ile Ser Pro Ser Asn Met Thr 
            340                 345                 350         


Asn Gln Asn Thr Pro Glu Tyr Met Glu Lys Ile Lys Gln Arg Leu Phe 
        355                 360                 365             


Glu Asn Leu Arg Met Leu Pro His Ala Pro Gly Val Gln Met Gln Ala 
    370                 375                 380                 


Ile Pro Glu Asp Ala Val His Glu Asp Ser Gly Asp Glu Asp Gly Glu 
385                 390                 395                 400 


Asp Pro Asp Lys Arg Ile Ser Ile Arg Ala Ser Asp Lys Arg Ile Ala 
                405                 410                 415     


Cys Asp Glu Glu Phe Ser Asp Ser Glu Asp Glu Gly Glu Gly Gly Arg 
            420                 425                 430         


Arg Asn Val Ala Asp His Lys Lys Gly Ala Lys Lys Ala Arg Ile Glu 
        435                 440                 445             


Glu Asp Lys Lys Glu Thr Glu Asp Lys Lys Thr Asp Val Lys Glu Glu 
    450                 455                 460                 


Asp Lys Ser Lys Asp Asn Ser Gly Glu Lys Thr Asp Thr Lys Gly Thr 
465                 470                 475                 480 


Lys Ser Glu Gln Leu Ser Asn Pro 
                485             


<210>  17
<211>  428
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q13938
<309>  2016-09-07
<313>  (1)..(428)

<400>  17

Met Ala Glu Asn Asp Val Asp Asn Glu Leu Leu Asp Tyr Glu Asp Asp 
1               5                   10                  15      


Glu Val Glu Thr Ala Ala Gly Gly Asp Gly Ala Glu Ala Pro Ala Lys 
            20                  25                  30          


Lys Asp Val Lys Gly Ser Tyr Val Ser Ile His Ser Ser Gly Phe Arg 
        35                  40                  45              


Asp Phe Leu Leu Lys Pro Glu Leu Leu Arg Ala Ile Val Asp Cys Gly 
    50                  55                  60                  


Phe Glu His Pro Ser Glu Val Gln His Glu Cys Ile Pro Gln Ala Ile 
65                  70                  75                  80  


Leu Gly Met Asp Val Leu Cys Gln Ala Lys Ser Gly Met Gly Lys Thr 
                85                  90                  95      


Ala Val Phe Val Leu Ala Thr Leu Gln Gln Leu Glu Pro Val Thr Gly 
            100                 105                 110         


Gln Val Ser Val Leu Val Met Cys His Thr Arg Glu Leu Ala Phe Gln 
        115                 120                 125             


Ile Ser Lys Glu Tyr Glu Arg Phe Ser Lys Tyr Met Pro Asn Val Lys 
    130                 135                 140                 


Val Ala Val Phe Phe Gly Gly Leu Ser Ile Lys Lys Asp Glu Glu Val 
145                 150                 155                 160 


Leu Lys Lys Asn Cys Pro His Ile Val Val Gly Thr Pro Gly Arg Ile 
                165                 170                 175     


Leu Ala Leu Ala Arg Asn Lys Ser Leu Asn Leu Lys His Ile Lys His 
            180                 185                 190         


Phe Ile Leu Asp Glu Cys Asp Lys Met Leu Glu Gln Leu Asp Met Arg 
        195                 200                 205             


Arg Asp Val Gln Glu Ile Phe Arg Met Thr Pro His Glu Lys Gln Val 
    210                 215                 220                 


Met Met Phe Ser Ala Thr Leu Ser Lys Glu Ile Arg Pro Val Cys Arg 
225                 230                 235                 240 


Lys Phe Met Gln Asp Pro Met Glu Ile Phe Val Asp Asp Glu Thr Lys 
                245                 250                 255     


Leu Thr Leu His Gly Leu Gln Gln Tyr Tyr Val Lys Leu Lys Asp Asn 
            260                 265                 270         


Glu Lys Asn Arg Lys Leu Phe Asp Leu Leu Asp Val Leu Glu Phe Asn 
        275                 280                 285             


Gln Val Val Ile Phe Val Lys Ser Val Gln Arg Cys Ile Ala Leu Ala 
    290                 295                 300                 


Gln Leu Leu Val Glu Gln Asn Phe Pro Ala Ile Ala Ile His Arg Gly 
305                 310                 315                 320 


Met Pro Gln Glu Glu Arg Leu Ser Arg Tyr Gln Gln Phe Lys Asp Phe 
                325                 330                 335     


Gln Arg Arg Ile Leu Val Ala Thr Asn Leu Phe Gly Arg Gly Met Asp 
            340                 345                 350         


Ile Glu Arg Val Asn Ile Ala Phe Asn Tyr Asp Met Pro Glu Asp Ser 
        355                 360                 365             


Asp Thr Tyr Leu His Arg Val Ala Arg Ala Gly Arg Phe Gly Thr Lys 
    370                 375                 380                 


Gly Leu Ala Ile Thr Phe Val Ser Asp Glu Asn Asp Ala Lys Ile Leu 
385                 390                 395                 400 


Asn Asp Val Gln Asp Arg Phe Glu Val Asn Ile Ser Glu Leu Pro Asp 
                405                 410                 415     


Glu Ile Asp Ile Ser Ser Tyr Ile Glu Gln Thr Arg 
            420                 425             


<210>  18
<211>  609
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P12956
<309>  2016-09-07
<313>  (1)..(609)

<400>  18

Met Ser Gly Trp Glu Ser Tyr Tyr Lys Thr Glu Gly Asp Glu Glu Ala 
1               5                   10                  15      


Glu Glu Glu Gln Glu Glu Asn Leu Glu Ala Ser Gly Asp Tyr Lys Tyr 
            20                  25                  30          


Ser Gly Arg Asp Ser Leu Ile Phe Leu Val Asp Ala Ser Lys Ala Met 
        35                  40                  45              


Phe Glu Ser Gln Ser Glu Asp Glu Leu Thr Pro Phe Asp Met Ser Ile 
    50                  55                  60                  


Gln Cys Ile Gln Ser Val Tyr Ile Ser Lys Ile Ile Ser Ser Asp Arg 
65                  70                  75                  80  


Asp Leu Leu Ala Val Val Phe Tyr Gly Thr Glu Lys Asp Lys Asn Ser 
                85                  90                  95      


Val Asn Phe Lys Asn Ile Tyr Val Leu Gln Glu Leu Asp Asn Pro Gly 
            100                 105                 110         


Ala Lys Arg Ile Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Gln 
        115                 120                 125             


Lys Arg Phe Gln Asp Met Met Gly His Gly Ser Asp Tyr Ser Leu Ser 
    130                 135                 140                 


Glu Val Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Phe Lys 
145                 150                 155                 160 


Met Ser His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asn Pro His 
                165                 170                 175     


Gly Asn Asp Ser Ala Lys Ala Ser Arg Ala Arg Thr Lys Ala Gly Asp 
            180                 185                 190         


Leu Arg Asp Thr Gly Ile Phe Leu Asp Leu Met His Leu Lys Lys Pro 
        195                 200                 205             


Gly Gly Phe Asp Ile Ser Leu Phe Tyr Arg Asp Ile Ile Ser Ile Ala 
    210                 215                 220                 


Glu Asp Glu Asp Leu Arg Val His Phe Glu Glu Ser Ser Lys Leu Glu 
225                 230                 235                 240 


Asp Leu Leu Arg Lys Val Arg Ala Lys Glu Thr Arg Lys Arg Ala Leu 
                245                 250                 255     


Ser Arg Leu Lys Leu Lys Leu Asn Lys Asp Ile Val Ile Ser Val Gly 
            260                 265                 270         


Ile Tyr Asn Leu Val Gln Lys Ala Leu Lys Pro Pro Pro Ile Lys Leu 
        275                 280                 285             


Tyr Arg Glu Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe Asn 
    290                 295                 300                 


Thr Ser Thr Gly Gly Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser Gln 
305                 310                 315                 320 


Ile Tyr Gly Ser Arg Gln Ile Ile Leu Glu Lys Glu Glu Thr Glu Glu 
                325                 330                 335     


Leu Lys Arg Phe Asp Asp Pro Gly Leu Met Leu Met Gly Phe Lys Pro 
            340                 345                 350         


Leu Val Leu Leu Lys Lys His His Tyr Leu Arg Pro Ser Leu Phe Val 
        355                 360                 365             


Tyr Pro Glu Glu Ser Leu Val Ile Gly Ser Ser Thr Leu Phe Ser Ala 
    370                 375                 380                 


Leu Leu Ile Lys Cys Leu Glu Lys Glu Val Ala Ala Leu Cys Arg Tyr 
385                 390                 395                 400 


Thr Pro Arg Arg Asn Ile Pro Pro Tyr Phe Val Ala Leu Val Pro Gln 
                405                 410                 415     


Glu Glu Glu Leu Asp Asp Gln Lys Ile Gln Val Thr Pro Pro Gly Phe 
            420                 425                 430         


Gln Leu Val Phe Leu Pro Phe Ala Asp Asp Lys Arg Lys Met Pro Phe 
        435                 440                 445             


Thr Glu Lys Ile Met Ala Thr Pro Glu Gln Val Gly Lys Met Lys Ala 
    450                 455                 460                 


Ile Val Glu Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu Asn 
465                 470                 475                 480 


Pro Val Leu Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu Asp 
                485                 490                 495     


Leu Met Glu Pro Glu Gln Ala Val Asp Leu Thr Leu Pro Lys Val Glu 
            500                 505                 510         


Ala Met Asn Lys Arg Leu Gly Ser Leu Val Asp Glu Phe Lys Glu Leu 
        515                 520                 525             


Val Tyr Pro Pro Asp Tyr Asn Pro Glu Gly Lys Val Thr Lys Arg Lys 
    530                 535                 540                 


His Asp Asn Glu Gly Ser Gly Ser Lys Arg Pro Lys Val Glu Tyr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Lys Thr His Ile Ser Lys Gly Thr Leu Gly Lys Phe 
                565                 570                 575     


Thr Val Pro Met Leu Lys Glu Ala Cys Arg Ala Tyr Gly Leu Lys Ser 
            580                 585                 590         


Gly Leu Lys Lys Gln Glu Leu Leu Glu Ala Leu Thr Lys His Phe Gln 
        595                 600                 605             


Asp 
    


<210>  19
<211>  205
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P04792
<309>  2016-09-07
<313>  (1)..(205)

<400>  19

Met Thr Glu Arg Arg Val Pro Phe Ser Leu Leu Arg Gly Pro Ser Trp 
1               5                   10                  15      


Asp Pro Phe Arg Asp Trp Tyr Pro His Ser Arg Leu Phe Asp Gln Ala 
            20                  25                  30          


Phe Gly Leu Pro Arg Leu Pro Glu Glu Trp Ser Gln Trp Leu Gly Gly 
        35                  40                  45              


Ser Ser Trp Pro Gly Tyr Val Arg Pro Leu Pro Pro Ala Ala Ile Glu 
    50                  55                  60                  


Ser Pro Ala Val Ala Ala Pro Ala Tyr Ser Arg Ala Leu Ser Arg Gln 
65                  70                  75                  80  


Leu Ser Ser Gly Val Ser Glu Ile Arg His Thr Ala Asp Arg Trp Arg 
                85                  90                  95      


Val Ser Leu Asp Val Asn His Phe Ala Pro Asp Glu Leu Thr Val Lys 
            100                 105                 110         


Thr Lys Asp Gly Val Val Glu Ile Thr Gly Lys His Glu Glu Arg Gln 
        115                 120                 125             


Asp Glu His Gly Tyr Ile Ser Arg Cys Phe Thr Arg Lys Tyr Thr Leu 
    130                 135                 140                 


Pro Pro Gly Val Asp Pro Thr Gln Val Ser Ser Ser Leu Ser Pro Glu 
145                 150                 155                 160 


Gly Thr Leu Thr Val Glu Ala Pro Met Pro Lys Leu Ala Thr Gln Ser 
                165                 170                 175     


Asn Glu Ile Thr Ile Pro Val Thr Phe Glu Ser Arg Ala Gln Leu Gly 
            180                 185                 190         


Gly Pro Glu Ala Ala Lys Ser Asp Glu Thr Ala Ala Lys 
        195                 200                 205 


<210>  20
<211>  641
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P08107
<309>  2016-04-29
<313>  (1)..(641)

<400>  20

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  21
<211>  646
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P11142
<309>  1993-04-23
<313>  (1)..(646)

<400>  21

Met Ser Lys Gly Pro Ala Val Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Met Asn Pro Thr 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Arg Phe Asp Asp 
65                  70                  75                  80  


Ala Val Val Gln Ser Asp Met Lys His Trp Pro Phe Met Val Val Asn 
                85                  90                  95      


Asp Ala Gly Arg Pro Lys Val Gln Val Glu Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ser Phe Tyr Pro Glu Glu Val Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Lys Thr Val Thr Asn Ala Val Val 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Thr Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Lys Lys Val Gly Ala Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Glu Asp Gly Ile Phe Glu Val Lys Ser Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Met Val Asn His 
225                 230                 235                 240 


Phe Ile Ala Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Glu Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Ile Glu Ile Asp Ser Leu Tyr 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Asn Ala Asp Leu Phe Arg Gly Thr Leu Asp Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ser Gln Ile His Asp Ile Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Ile Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Lys Glu Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Ser Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Thr Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Ile Glu Thr Ala Gly Gly Val Met Thr Val Leu Ile Lys Arg 
                405                 410                 415     


Asn Thr Thr Ile Pro Thr Lys Gln Thr Gln Thr Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Lys Phe Glu Leu Thr Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Ser Ala Val Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Glu Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Asp Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Lys Gln Arg Asp Lys Val Ser Ser Lys Asn Ser Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ala Thr Val Glu Asp Glu Lys Leu Gln Gly 
545                 550                 555                 560 


Lys Ile Asn Asp Glu Asp Lys Gln Lys Ile Leu Asp Lys Cys Asn Glu 
                565                 570                 575     


Ile Ile Asn Trp Leu Asp Lys Asn Gln Thr Ala Glu Lys Glu Glu Phe 
            580                 585                 590         


Glu His Gln Gln Lys Glu Leu Glu Lys Val Cys Asn Pro Ile Ile Thr 
        595                 600                 605             


Lys Leu Tyr Gln Ser Ala Gly Gly Met Pro Gly Gly Met Pro Gly Gly 
    610                 615                 620                 


Phe Pro Gly Gly Gly Ala Pro Pro Ser Gly Gly Ala Ser Ser Gly Pro 
625                 630                 635                 640 


Thr Ile Glu Glu Val Asp 
                645     


<210>  22
<211>  770
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P05067
<309>  1993-04-23
<313>  (1)..(770)

<400>  22

Met Leu Pro Gly Leu Ala Leu Leu Leu Leu Ala Ala Trp Thr Ala Arg 
1               5                   10                  15      


Ala Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro 
            20                  25                  30          


Gln Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln 
        35                  40                  45              


Asn Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp 
    50                  55                  60                  


Thr Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu 
65                  70                  75                  80  


Gln Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn 
                85                  90                  95      


Trp Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val 
            100                 105                 110         


Ile Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu 
        115                 120                 125             


Val Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys 
    130                 135                 140                 


Glu Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu 
145                 150                 155                 160 


Lys Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile 
                165                 170                 175     


Asp Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu 
            180                 185                 190         


Ser Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val 
        195                 200                 205             


Trp Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys 
    210                 215                 220                 


Val Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu 
225                 230                 235                 240 


Glu Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu 
                245                 250                 255     


Glu Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile 
            260                 265                 270         


Ala Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg 
        275                 280                 285             


Glu Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile 
    290                 295                 300                 


Ser Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe 
305                 310                 315                 320 


Tyr Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr 
                325                 330                 335     


Cys Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr 
            340                 345                 350         


Thr Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala 
        355                 360                 365             


Ala Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp 
    370                 375                 380                 


Glu Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala 
385                 390                 395                 400 


Lys His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala 
                405                 410                 415     


Glu Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile 
            420                 425                 430         


Gln His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn 
        435                 440                 445             


Glu Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met 
    450                 455                 460                 


Leu Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu 
465                 470                 475                 480 


Gln Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys 
                485                 490                 495     


Tyr Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe 
            500                 505                 510         


Glu His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser 
        515                 520                 525             


Gln Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser 
    530                 535                 540                 


Leu Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp 
545                 550                 555                 560 


Glu Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val 
                565                 570                 575     


Leu Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala 
            580                 585                 590         


Leu Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro 
        595                 600                 605             


Val Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe 
    610                 615                 620                 


Gly Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val 
625                 630                 635                 640 


Asp Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser 
                645                 650                 655     


Gly Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp 
            660                 665                 670         


Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu 
        675                 680                 685             


Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 
    690                 695                 700                 


Leu Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu 
705                 710                 715                 720 


Val Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val 
                725                 730                 735     


Glu Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met 
            740                 745                 750         


Gln Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met 
        755                 760                 765             


Gln Asn 
    770 


<210>  23
<211>  835
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q13263
<309>  2016-09-07
<313>  (1)..(835)

<400>  23

Met Ala Ala Ser Ala Ala Ala Ala Ser Ala Ala Ala Ala Ser Ala Ala 
1               5                   10                  15      


Ser Gly Ser Pro Gly Pro Gly Glu Gly Ser Ala Gly Gly Glu Lys Arg 
            20                  25                  30          


Ser Thr Ala Pro Ser Ala Ala Ala Ser Ala Ser Ala Ser Ala Ala Ala 
        35                  40                  45              


Ser Ser Pro Ala Gly Gly Gly Ala Glu Ala Leu Glu Leu Leu Glu His 
    50                  55                  60                  


Cys Gly Val Cys Arg Glu Arg Leu Arg Pro Glu Arg Glu Pro Arg Leu 
65                  70                  75                  80  


Leu Pro Cys Leu His Ser Ala Cys Ser Ala Cys Leu Gly Pro Ala Ala 
                85                  90                  95      


Pro Ala Ala Ala Asn Ser Ser Gly Asp Gly Gly Ala Ala Gly Asp Gly 
            100                 105                 110         


Thr Val Val Asp Cys Pro Val Cys Lys Gln Gln Cys Phe Ser Lys Asp 
        115                 120                 125             


Ile Val Glu Asn Tyr Phe Met Arg Asp Ser Gly Ser Lys Ala Ala Thr 
    130                 135                 140                 


Asp Ala Gln Asp Ala Asn Gln Cys Cys Thr Ser Cys Glu Asp Asn Ala 
145                 150                 155                 160 


Pro Ala Thr Ser Tyr Cys Val Glu Cys Ser Glu Pro Leu Cys Glu Thr 
                165                 170                 175     


Cys Val Glu Ala His Gln Arg Val Lys Tyr Thr Lys Asp His Thr Val 
            180                 185                 190         


Arg Ser Thr Gly Pro Ala Lys Ser Arg Asp Gly Glu Arg Thr Val Tyr 
        195                 200                 205             


Cys Asn Val His Lys His Glu Pro Leu Val Leu Phe Cys Glu Ser Cys 
    210                 215                 220                 


Asp Thr Leu Thr Cys Arg Asp Cys Gln Leu Asn Ala His Lys Asp His 
225                 230                 235                 240 


Gln Tyr Gln Phe Leu Glu Asp Ala Val Arg Asn Gln Arg Lys Leu Leu 
                245                 250                 255     


Ala Ser Leu Val Lys Arg Leu Gly Asp Lys His Ala Thr Leu Gln Lys 
            260                 265                 270         


Ser Thr Lys Glu Val Arg Ser Ser Ile Arg Gln Val Ser Asp Val Gln 
        275                 280                 285             


Lys Arg Val Gln Val Asp Val Lys Met Ala Ile Leu Gln Ile Met Lys 
    290                 295                 300                 


Glu Leu Asn Lys Arg Gly Arg Val Leu Val Asn Asp Ala Gln Lys Val 
305                 310                 315                 320 


Thr Glu Gly Gln Gln Glu Arg Leu Glu Arg Gln His Trp Thr Met Thr 
                325                 330                 335     


Lys Ile Gln Lys His Gln Glu His Ile Leu Arg Phe Ala Ser Trp Ala 
            340                 345                 350         


Leu Glu Ser Asp Asn Asn Thr Ala Leu Leu Leu Ser Lys Lys Leu Ile 
        355                 360                 365             


Tyr Phe Gln Leu His Arg Ala Leu Lys Met Ile Val Asp Pro Val Glu 
    370                 375                 380                 


Pro His Gly Glu Met Lys Phe Gln Trp Asp Leu Asn Ala Trp Thr Lys 
385                 390                 395                 400 


Ser Ala Glu Ala Phe Gly Lys Ile Val Ala Glu Arg Pro Gly Thr Asn 
                405                 410                 415     


Ser Thr Gly Pro Ala Pro Met Ala Pro Pro Arg Ala Pro Gly Pro Leu 
            420                 425                 430         


Ser Lys Gln Gly Ser Gly Ser Ser Gln Pro Met Glu Val Gln Glu Gly 
        435                 440                 445             


Tyr Gly Phe Gly Ser Gly Asp Asp Pro Tyr Ser Ser Ala Glu Pro His 
    450                 455                 460                 


Val Ser Gly Val Lys Arg Ser Arg Ser Gly Glu Gly Glu Val Ser Gly 
465                 470                 475                 480 


Leu Met Arg Lys Val Pro Arg Val Ser Leu Glu Arg Leu Asp Leu Asp 
                485                 490                 495     


Leu Thr Ala Asp Ser Gln Pro Pro Val Phe Lys Val Phe Pro Gly Ser 
            500                 505                 510         


Thr Thr Glu Asp Tyr Asn Leu Ile Val Ile Glu Arg Gly Ala Ala Ala 
        515                 520                 525             


Ala Ala Thr Gly Gln Pro Gly Thr Ala Pro Ala Gly Thr Pro Gly Ala 
    530                 535                 540                 


Pro Pro Leu Ala Gly Met Ala Ile Val Lys Glu Glu Glu Thr Glu Ala 
545                 550                 555                 560 


Ala Ile Gly Ala Pro Pro Thr Ala Thr Glu Gly Pro Glu Thr Lys Pro 
                565                 570                 575     


Val Leu Met Ala Leu Ala Glu Gly Pro Gly Ala Glu Gly Pro Arg Leu 
            580                 585                 590         


Ala Ser Pro Ser Gly Ser Thr Ser Ser Gly Leu Glu Val Val Ala Pro 
        595                 600                 605             


Glu Gly Thr Ser Ala Pro Gly Gly Gly Pro Gly Thr Leu Asp Asp Ser 
    610                 615                 620                 


Ala Thr Ile Cys Arg Val Cys Gln Lys Pro Gly Asp Leu Val Met Cys 
625                 630                 635                 640 


Asn Gln Cys Glu Phe Cys Phe His Leu Asp Cys His Leu Pro Ala Leu 
                645                 650                 655     


Gln Asp Val Pro Gly Glu Glu Trp Ser Cys Ser Leu Cys His Val Leu 
            660                 665                 670         


Pro Asp Leu Lys Glu Glu Asp Gly Ser Leu Ser Leu Asp Gly Ala Asp 
        675                 680                 685             


Ser Thr Gly Val Val Ala Lys Leu Ser Pro Ala Asn Gln Arg Lys Cys 
    690                 695                 700                 


Glu Arg Val Leu Leu Ala Leu Phe Cys His Glu Pro Cys Arg Pro Leu 
705                 710                 715                 720 


His Gln Leu Ala Thr Asp Ser Thr Phe Ser Leu Asp Gln Pro Gly Gly 
                725                 730                 735     


Thr Leu Asp Leu Thr Leu Ile Arg Ala Arg Leu Gln Glu Lys Leu Ser 
            740                 745                 750         


Pro Pro Tyr Ser Ser Pro Gln Glu Phe Ala Gln Asp Val Gly Arg Met 
        755                 760                 765             


Phe Lys Gln Phe Asn Lys Leu Thr Glu Asp Lys Ala Asp Val Gln Ser 
    770                 775                 780                 


Ile Ile Gly Leu Gln Arg Phe Phe Glu Thr Arg Met Asn Glu Ala Phe 
785                 790                 795                 800 


Gly Asp Thr Lys Phe Ser Ala Val Leu Val Glu Pro Pro Pro Met Ser 
                805                 810                 815     


Leu Pro Gly Ala Gly Leu Ser Ser Gln Glu Leu Ser Gly Gly Pro Gly 
            820                 825                 830         


Asp Gly Pro 
        835 


<210>  24
<211>  2492
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P46100
<309>  2016-09-07
<313>  (1)..(2492)

<400>  24

Met Thr Ala Glu Pro Met Ser Glu Ser Lys Leu Asn Thr Leu Val Gln 
1               5                   10                  15      


Lys Leu His Asp Phe Leu Ala His Ser Ser Glu Glu Ser Glu Glu Thr 
            20                  25                  30          


Ser Ser Pro Pro Arg Leu Ala Met Asn Gln Asn Thr Asp Lys Ile Ser 
        35                  40                  45              


Gly Ser Gly Ser Asn Ser Asp Met Met Glu Asn Ser Lys Glu Glu Gly 
    50                  55                  60                  


Thr Ser Ser Ser Glu Lys Ser Lys Ser Ser Gly Ser Ser Arg Ser Lys 
65                  70                  75                  80  


Arg Lys Pro Ser Ile Val Thr Lys Tyr Val Glu Ser Asp Asp Glu Lys 
                85                  90                  95      


Pro Leu Asp Asp Glu Thr Val Asn Glu Asp Ala Ser Asn Glu Asn Ser 
            100                 105                 110         


Glu Asn Asp Ile Thr Met Gln Ser Leu Pro Lys Gly Thr Val Ile Val 
        115                 120                 125             


Gln Pro Glu Pro Val Leu Asn Glu Asp Lys Asp Asp Phe Lys Gly Pro 
    130                 135                 140                 


Glu Phe Arg Ser Arg Ser Lys Met Lys Thr Glu Asn Leu Lys Lys Arg 
145                 150                 155                 160 


Gly Glu Asp Gly Leu His Gly Ile Val Ser Cys Thr Ala Cys Gly Gln 
                165                 170                 175     


Gln Val Asn His Phe Gln Lys Asp Ser Ile Tyr Arg His Pro Ser Leu 
            180                 185                 190         


Gln Val Leu Ile Cys Lys Asn Cys Phe Lys Tyr Tyr Met Ser Asp Asp 
        195                 200                 205             


Ile Ser Arg Asp Ser Asp Gly Met Asp Glu Gln Cys Arg Trp Cys Ala 
    210                 215                 220                 


Glu Gly Gly Asn Leu Ile Cys Cys Asp Phe Cys His Asn Ala Phe Cys 
225                 230                 235                 240 


Lys Lys Cys Ile Leu Arg Asn Leu Gly Arg Lys Glu Leu Ser Thr Ile 
                245                 250                 255     


Met Asp Glu Asn Asn Gln Trp Tyr Cys Tyr Ile Cys His Pro Glu Pro 
            260                 265                 270         


Leu Leu Asp Leu Val Thr Ala Cys Asn Ser Val Phe Glu Asn Leu Glu 
        275                 280                 285             


Gln Leu Leu Gln Gln Asn Lys Lys Lys Ile Lys Val Asp Ser Glu Lys 
    290                 295                 300                 


Ser Asn Lys Val Tyr Glu His Thr Ser Arg Phe Ser Pro Lys Lys Thr 
305                 310                 315                 320 


Ser Ser Asn Cys Asn Gly Glu Glu Lys Lys Leu Asp Asp Ser Cys Ser 
                325                 330                 335     


Gly Ser Val Thr Tyr Ser Tyr Ser Ala Leu Ile Val Pro Lys Glu Met 
            340                 345                 350         


Ile Lys Lys Ala Lys Lys Leu Ile Glu Thr Thr Ala Asn Met Asn Ser 
        355                 360                 365             


Ser Tyr Val Lys Phe Leu Lys Gln Ala Thr Asp Asn Ser Glu Ile Ser 
    370                 375                 380                 


Ser Ala Thr Lys Leu Arg Gln Leu Lys Ala Phe Lys Ser Val Leu Ala 
385                 390                 395                 400 


Asp Ile Lys Lys Ala His Leu Ala Leu Glu Glu Asp Leu Asn Ser Glu 
                405                 410                 415     


Phe Arg Ala Met Asp Ala Val Asn Lys Glu Lys Asn Thr Lys Glu His 
            420                 425                 430         


Lys Val Ile Asp Ala Lys Phe Glu Thr Lys Ala Arg Lys Gly Glu Lys 
        435                 440                 445             


Pro Cys Ala Leu Glu Lys Lys Asp Ile Ser Lys Ser Glu Ala Lys Leu 
    450                 455                 460                 


Ser Arg Lys Gln Val Asp Ser Glu His Met His Gln Asn Val Pro Thr 
465                 470                 475                 480 


Glu Glu Gln Arg Thr Asn Lys Ser Thr Gly Gly Glu His Lys Lys Ser 
                485                 490                 495     


Asp Arg Lys Glu Glu Pro Gln Tyr Glu Pro Ala Asn Thr Ser Glu Asp 
            500                 505                 510         


Leu Asp Met Asp Ile Val Ser Val Pro Ser Ser Val Pro Glu Asp Ile 
        515                 520                 525             


Phe Glu Asn Leu Glu Thr Ala Met Glu Val Gln Ser Ser Val Asp His 
    530                 535                 540                 


Gln Gly Asp Gly Ser Ser Gly Thr Glu Gln Glu Val Glu Ser Ser Ser 
545                 550                 555                 560 


Val Lys Leu Asn Ile Ser Ser Lys Asp Asn Arg Gly Gly Ile Lys Ser 
                565                 570                 575     


Lys Thr Thr Ala Lys Val Thr Lys Glu Leu Tyr Val Lys Leu Thr Pro 
            580                 585                 590         


Val Ser Leu Ser Asn Ser Pro Ile Lys Gly Ala Asp Cys Gln Glu Val 
        595                 600                 605             


Pro Gln Asp Lys Asp Gly Tyr Lys Ser Cys Gly Leu Asn Pro Lys Leu 
    610                 615                 620                 


Glu Lys Cys Gly Leu Gly Gln Glu Asn Ser Asp Asn Glu His Leu Val 
625                 630                 635                 640 


Glu Asn Glu Val Ser Leu Leu Leu Glu Glu Ser Asp Leu Arg Arg Ser 
                645                 650                 655     


Pro Arg Val Lys Thr Thr Pro Leu Arg Arg Pro Thr Glu Thr Asn Pro 
            660                 665                 670         


Val Thr Ser Asn Ser Asp Glu Glu Cys Asn Glu Thr Val Lys Glu Lys 
        675                 680                 685             


Gln Lys Leu Ser Val Pro Val Arg Lys Lys Asp Lys Arg Asn Ser Ser 
    690                 695                 700                 


Asp Ser Ala Ile Asp Asn Pro Lys Pro Asn Lys Leu Pro Lys Ser Lys 
705                 710                 715                 720 


Gln Ser Glu Thr Val Asp Gln Asn Ser Asp Ser Asp Glu Met Leu Ala 
                725                 730                 735     


Ile Leu Lys Glu Val Ser Arg Met Ser His Ser Ser Ser Ser Asp Thr 
            740                 745                 750         


Asp Ile Asn Glu Ile His Thr Asn His Lys Thr Leu Tyr Asp Leu Lys 
        755                 760                 765             


Thr Gln Ala Gly Lys Asp Asp Lys Gly Lys Arg Lys Arg Lys Ser Ser 
    770                 775                 780                 


Thr Ser Gly Ser Asp Phe Asp Thr Lys Lys Gly Lys Ser Ala Lys Ser 
785                 790                 795                 800 


Ser Ile Ile Ser Lys Lys Lys Arg Gln Thr Gln Ser Glu Ser Ser Asn 
                805                 810                 815     


Tyr Asp Ser Glu Leu Glu Lys Glu Ile Lys Ser Met Ser Lys Ile Gly 
            820                 825                 830         


Ala Ala Arg Thr Thr Lys Lys Arg Ile Pro Asn Thr Lys Asp Phe Asp 
        835                 840                 845             


Ser Ser Glu Asp Glu Lys His Ser Lys Lys Gly Met Asp Asn Gln Gly 
    850                 855                 860                 


His Lys Asn Leu Lys Thr Ser Gln Glu Gly Ser Ser Asp Asp Ala Glu 
865                 870                 875                 880 


Arg Lys Gln Glu Arg Glu Thr Phe Ser Ser Ala Glu Gly Thr Val Asp 
                885                 890                 895     


Lys Asp Thr Thr Ile Met Glu Leu Arg Asp Arg Leu Pro Lys Lys Gln 
            900                 905                 910         


Gln Ala Ser Ala Ser Thr Asp Gly Val Asp Lys Leu Ser Gly Lys Glu 
        915                 920                 925             


Gln Ser Phe Thr Ser Leu Glu Val Arg Lys Val Ala Glu Thr Lys Glu 
    930                 935                 940                 


Lys Ser Lys His Leu Lys Thr Lys Thr Cys Lys Lys Val Gln Asp Gly 
945                 950                 955                 960 


Leu Ser Asp Ile Ala Glu Lys Phe Leu Lys Lys Asp Gln Ser Asp Glu 
                965                 970                 975     


Thr Ser Glu Asp Asp Lys Lys Gln Ser Lys Lys Gly Thr Glu Glu Lys 
            980                 985                 990         


Lys Lys Pro Ser Asp Phe Lys Lys  Lys Val Ile Lys Met  Glu Gln Gln 
        995                 1000                 1005             


Tyr Glu  Ser Ser Ser Asp Gly  Thr Glu Lys Leu Pro  Glu Arg Glu 
    1010                 1015                 1020             


Glu Ile  Cys His Phe Pro Lys  Gly Ile Lys Gln Ile  Lys Asn Gly 
    1025                 1030                 1035             


Thr Thr  Asp Gly Glu Lys Lys  Ser Lys Lys Ile Arg  Asp Lys Thr 
    1040                 1045                 1050             


Ser Lys  Lys Lys Asp Glu Leu  Ser Asp Tyr Ala Glu  Lys Ser Thr 
    1055                 1060                 1065             


Gly Lys  Gly Asp Ser Cys Asp  Ser Ser Glu Asp Lys  Lys Ser Lys 
    1070                 1075                 1080             


Asn Gly  Ala Tyr Gly Arg Glu  Lys Lys Arg Cys Lys  Leu Leu Gly 
    1085                 1090                 1095             


Lys Ser  Ser Arg Lys Arg Gln  Asp Cys Ser Ser Ser  Asp Thr Glu 
    1100                 1105                 1110             


Lys Tyr  Ser Met Lys Glu Asp  Gly Cys Asn Ser Ser  Asp Lys Arg 
    1115                 1120                 1125             


Leu Lys  Arg Ile Glu Leu Arg  Glu Arg Arg Asn Leu  Ser Ser Lys 
    1130                 1135                 1140             


Arg Asn  Thr Lys Glu Ile Gln  Ser Gly Ser Ser Ser  Ser Asp Ala 
    1145                 1150                 1155             


Glu Glu  Ser Ser Glu Asp Asn  Lys Lys Lys Lys Gln  Arg Thr Ser 
    1160                 1165                 1170             


Ser Lys  Lys Lys Ala Val Ile  Val Lys Glu Lys Lys  Arg Asn Ser 
    1175                 1180                 1185             


Leu Arg  Thr Ser Thr Lys Arg  Lys Gln Ala Asp Ile  Thr Ser Ser 
    1190                 1195                 1200             


Ser Ser  Ser Asp Ile Glu Asp  Asp Asp Gln Asn Ser  Ile Gly Glu 
    1205                 1210                 1215             


Gly Ser  Ser Asp Glu Gln Lys  Ile Lys Pro Val Thr  Glu Asn Leu 
    1220                 1225                 1230             


Val Leu  Ser Ser His Thr Gly  Phe Cys Gln Ser Ser  Gly Asp Glu 
    1235                 1240                 1245             


Ala Leu  Ser Lys Ser Val Pro  Val Thr Val Asp Asp  Asp Asp Asp 
    1250                 1255                 1260             


Asp Asn  Asp Pro Glu Asn Arg  Ile Ala Lys Lys Met  Leu Leu Glu 
    1265                 1270                 1275             


Glu Ile  Lys Ala Asn Leu Ser  Ser Asp Glu Asp Gly  Ser Ser Asp 
    1280                 1285                 1290             


Asp Glu  Pro Glu Glu Gly Lys  Lys Arg Thr Gly Lys  Gln Asn Glu 
    1295                 1300                 1305             


Glu Asn  Pro Gly Asp Glu Glu  Ala Lys Asn Gln Val  Asn Ser Glu 
    1310                 1315                 1320             


Ser Asp  Ser Asp Ser Glu Glu  Ser Lys Lys Pro Arg  Tyr Arg His 
    1325                 1330                 1335             


Arg Leu  Leu Arg His Lys Leu  Thr Val Ser Asp Gly  Glu Ser Gly 
    1340                 1345                 1350             


Glu Glu  Lys Lys Thr Lys Pro  Lys Glu His Lys Glu  Val Lys Gly 
    1355                 1360                 1365             


Arg Asn  Arg Arg Lys Val Ser  Ser Glu Asp Ser Glu  Asp Ser Asp 
    1370                 1375                 1380             


Phe Gln  Glu Ser Gly Val Ser  Glu Glu Val Ser Glu  Ser Glu Asp 
    1385                 1390                 1395             


Glu Gln  Arg Pro Arg Thr Arg  Ser Ala Lys Lys Ala  Glu Leu Glu 
    1400                 1405                 1410             


Glu Asn  Gln Arg Ser Tyr Lys  Gln Lys Lys Lys Arg  Arg Arg Ile 
    1415                 1420                 1425             


Lys Val  Gln Glu Asp Ser Ser  Ser Glu Asn Lys Ser  Asn Ser Glu 
    1430                 1435                 1440             


Glu Glu  Glu Glu Glu Lys Glu  Glu Glu Glu Glu Glu  Glu Glu Glu 
    1445                 1450                 1455             


Glu Glu  Glu Glu Glu Glu Asp  Glu Asn Asp Asp Ser  Lys Ser Pro 
    1460                 1465                 1470             


Gly Lys  Gly Arg Lys Lys Ile  Arg Lys Ile Leu Lys  Asp Asp Lys 
    1475                 1480                 1485             


Leu Arg  Thr Glu Thr Gln Asn  Ala Leu Lys Glu Glu  Glu Glu Arg 
    1490                 1495                 1500             


Arg Lys  Arg Ile Ala Glu Arg  Glu Arg Glu Arg Glu  Lys Leu Arg 
    1505                 1510                 1515             


Glu Val  Ile Glu Ile Glu Asp  Ala Ser Pro Thr Lys  Cys Pro Ile 
    1520                 1525                 1530             


Thr Thr  Lys Leu Val Leu Asp  Glu Asp Glu Glu Thr  Lys Glu Pro 
    1535                 1540                 1545             


Leu Val  Gln Val His Arg Asn  Met Val Ile Lys Leu  Lys Pro His 
    1550                 1555                 1560             


Gln Val  Asp Gly Val Gln Phe  Met Trp Asp Cys Cys  Cys Glu Ser 
    1565                 1570                 1575             


Val Lys  Lys Thr Lys Lys Ser  Pro Gly Ser Gly Cys  Ile Leu Ala 
    1580                 1585                 1590             


His Cys  Met Gly Leu Gly Lys  Thr Leu Gln Val Val  Ser Phe Leu 
    1595                 1600                 1605             


His Thr  Val Leu Leu Cys Asp  Lys Leu Asp Phe Ser  Thr Ala Leu 
    1610                 1615                 1620             


Val Val  Cys Pro Leu Asn Thr  Ala Leu Asn Trp Met  Asn Glu Phe 
    1625                 1630                 1635             


Glu Lys  Trp Gln Glu Gly Leu  Lys Asp Asp Glu Lys  Leu Glu Val 
    1640                 1645                 1650             


Ser Glu  Leu Ala Thr Val Lys  Arg Pro Gln Glu Arg  Ser Tyr Met 
    1655                 1660                 1665             


Leu Gln  Arg Trp Gln Glu Asp  Gly Gly Val Met Ile  Ile Gly Tyr 
    1670                 1675                 1680             


Glu Met  Tyr Arg Asn Leu Ala  Gln Gly Arg Asn Val  Lys Ser Arg 
    1685                 1690                 1695             


Lys Leu  Lys Glu Ile Phe Asn  Lys Ala Leu Val Asp  Pro Gly Pro 
    1700                 1705                 1710             


Asp Phe  Val Val Cys Asp Glu  Gly His Ile Leu Lys  Asn Glu Ala 
    1715                 1720                 1725             


Ser Ala  Val Ser Lys Ala Met  Asn Ser Ile Arg Ser  Arg Arg Arg 
    1730                 1735                 1740             


Ile Ile  Leu Thr Gly Thr Pro  Leu Gln Asn Asn Leu  Ile Glu Tyr 
    1745                 1750                 1755             


His Cys  Met Val Asn Phe Ile  Lys Glu Asn Leu Leu  Gly Ser Ile 
    1760                 1765                 1770             


Lys Glu  Phe Arg Asn Arg Phe  Ile Asn Pro Ile Gln  Asn Gly Gln 
    1775                 1780                 1785             


Cys Ala  Asp Ser Thr Met Val  Asp Val Arg Val Met  Lys Lys Arg 
    1790                 1795                 1800             


Ala His  Ile Leu Tyr Glu Met  Leu Ala Gly Cys Val  Gln Arg Lys 
    1805                 1810                 1815             


Asp Tyr  Thr Ala Leu Thr Lys  Phe Leu Pro Pro Lys  His Glu Tyr 
    1820                 1825                 1830             


Val Leu  Ala Val Arg Met Thr  Ser Ile Gln Cys Lys  Leu Tyr Gln 
    1835                 1840                 1845             


Tyr Tyr  Leu Asp His Leu Thr  Gly Val Gly Asn Asn  Ser Glu Gly 
    1850                 1855                 1860             


Gly Arg  Gly Lys Ala Gly Ala  Lys Leu Phe Gln Asp  Phe Gln Met 
    1865                 1870                 1875             


Leu Ser  Arg Ile Trp Thr His  Pro Trp Cys Leu Gln  Leu Asp Tyr 
    1880                 1885                 1890             


Ile Ser  Lys Glu Asn Lys Gly  Tyr Phe Asp Glu Asp  Ser Met Asp 
    1895                 1900                 1905             


Glu Phe  Ile Ala Ser Asp Ser  Asp Glu Thr Ser Met  Ser Leu Ser 
    1910                 1915                 1920             


Ser Asp  Asp Tyr Thr Lys Lys  Lys Lys Lys Gly Lys  Lys Gly Lys 
    1925                 1930                 1935             


Lys Asp  Ser Ser Ser Ser Gly  Ser Gly Ser Asp Asn  Asp Val Glu 
    1940                 1945                 1950             


Val Ile  Lys Val Trp Asn Ser  Arg Ser Arg Gly Gly  Gly Glu Gly 
    1955                 1960                 1965             


Asn Val  Asp Glu Thr Gly Asn  Asn Pro Ser Val Ser  Leu Lys Leu 
    1970                 1975                 1980             


Glu Glu  Ser Lys Ala Thr Ser  Ser Ser Asn Pro Ser  Ser Pro Ala 
    1985                 1990                 1995             


Pro Asp  Trp Tyr Lys Asp Phe  Val Thr Asp Ala Asp  Ala Glu Val 
    2000                 2005                 2010             


Leu Glu  His Ser Gly Lys Met  Val Leu Leu Phe Glu  Ile Leu Arg 
    2015                 2020                 2025             


Met Ala  Glu Glu Ile Gly Asp  Lys Val Leu Val Phe  Ser Gln Ser 
    2030                 2035                 2040             


Leu Ile  Ser Leu Asp Leu Ile  Glu Asp Phe Leu Glu  Leu Ala Ser 
    2045                 2050                 2055             


Arg Glu  Lys Thr Glu Asp Lys  Asp Lys Pro Leu Ile  Tyr Lys Gly 
    2060                 2065                 2070             


Glu Gly  Lys Trp Leu Arg Asn  Ile Asp Tyr Tyr Arg  Leu Asp Gly 
    2075                 2080                 2085             


Ser Thr  Thr Ala Gln Ser Arg  Lys Lys Trp Ala Glu  Glu Phe Asn 
    2090                 2095                 2100             


Asp Glu  Thr Asn Val Arg Gly  Arg Leu Phe Ile Ile  Ser Thr Lys 
    2105                 2110                 2115             


Ala Gly  Ser Leu Gly Ile Asn  Leu Val Ala Ala Asn  Arg Val Ile 
    2120                 2125                 2130             


Ile Phe  Asp Ala Ser Trp Asn  Pro Ser Tyr Asp Ile  Gln Ser Ile 
    2135                 2140                 2145             


Phe Arg  Val Tyr Arg Phe Gly  Gln Thr Lys Pro Val  Tyr Val Tyr 
    2150                 2155                 2160             


Arg Phe  Leu Ala Gln Gly Thr  Met Glu Asp Lys Ile  Tyr Asp Arg 
    2165                 2170                 2175             


Gln Val  Thr Lys Gln Ser Leu  Ser Phe Arg Val Val  Asp Gln Gln 
    2180                 2185                 2190             


Gln Val  Glu Arg His Phe Thr  Met Asn Glu Leu Thr  Glu Leu Tyr 
    2195                 2200                 2205             


Thr Phe  Glu Pro Asp Leu Leu  Asp Asp Pro Asn Ser  Glu Lys Lys 
    2210                 2215                 2220             


Lys Lys  Arg Asp Thr Pro Met  Leu Pro Lys Asp Thr  Ile Leu Ala 
    2225                 2230                 2235             


Glu Leu  Leu Gln Ile His Lys  Glu His Ile Val Gly  Tyr His Glu 
    2240                 2245                 2250             


His Asp  Ser Leu Leu Asp His  Lys Glu Glu Glu Glu  Leu Thr Glu 
    2255                 2260                 2265             


Glu Glu  Arg Lys Ala Ala Trp  Ala Glu Tyr Glu Ala  Glu Lys Lys 
    2270                 2275                 2280             


Gly Leu  Thr Met Arg Phe Asn  Ile Pro Thr Gly Thr  Asn Leu Pro 
    2285                 2290                 2295             


Pro Val  Ser Phe Asn Ser Gln  Thr Pro Tyr Ile Pro  Phe Asn Leu 
    2300                 2305                 2310             


Gly Ala  Leu Ser Ala Met Ser  Asn Gln Gln Leu Glu  Asp Leu Ile 
    2315                 2320                 2325             


Asn Gln  Gly Arg Glu Lys Val  Val Glu Ala Thr Asn  Ser Val Thr 
    2330                 2335                 2340             


Ala Val  Arg Ile Gln Pro Leu  Glu Asp Ile Ile Ser  Ala Val Trp 
    2345                 2350                 2355             


Lys Glu  Asn Met Asn Leu Ser  Glu Ala Gln Val Gln  Ala Leu Ala 
    2360                 2365                 2370             


Leu Ser  Arg Gln Ala Ser Gln  Glu Leu Asp Val Lys  Arg Arg Glu 
    2375                 2380                 2385             


Ala Ile  Tyr Asn Asp Val Leu  Thr Lys Gln Gln Met  Leu Ile Ser 
    2390                 2395                 2400             


Cys Val  Gln Arg Ile Leu Met  Asn Arg Arg Leu Gln  Gln Gln Tyr 
    2405                 2410                 2415             


Asn Gln  Gln Gln Gln Gln Gln  Met Thr Tyr Gln Gln  Ala Thr Leu 
    2420                 2425                 2430             


Gly His  Leu Met Met Pro Lys  Pro Pro Asn Leu Ile  Met Asn Pro 
    2435                 2440                 2445             


Ser Asn  Tyr Gln Gln Ile Asp  Met Arg Gly Met Tyr  Gln Pro Val 
    2450                 2455                 2460             


Ala Gly  Gly Met Gln Pro Pro  Pro Leu Gln Arg Ala  Pro Pro Pro 
    2465                 2470                 2475             


Met Arg  Ser Lys Asn Pro Gly  Pro Ser Gln Gly Lys  Ser Met 
    2480                 2485                 2490         


<210>  25
<211>  1462
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P09884
<309>  1993-04-23
<313>  (1)..(1462)

<400>  25

Met Ala Pro Val His Gly Asp Asp Ser Leu Ser Asp Ser Gly Ser Phe 
1               5                   10                  15      


Val Ser Ser Arg Ala Arg Arg Glu Lys Lys Ser Lys Lys Gly Arg Gln 
            20                  25                  30          


Glu Ala Leu Glu Arg Leu Lys Lys Ala Lys Ala Gly Glu Lys Tyr Lys 
        35                  40                  45              


Tyr Glu Val Glu Asp Phe Thr Gly Val Tyr Glu Glu Val Asp Glu Glu 
    50                  55                  60                  


Gln Tyr Ser Lys Leu Val Gln Ala Arg Gln Asp Asp Asp Trp Ile Val 
65                  70                  75                  80  


Asp Asp Asp Gly Ile Gly Tyr Val Glu Asp Gly Arg Glu Ile Phe Asp 
                85                  90                  95      


Asp Asp Leu Glu Asp Asp Ala Leu Asp Ala Asp Glu Lys Gly Lys Asp 
            100                 105                 110         


Gly Lys Ala Arg Asn Lys Asp Lys Arg Asn Val Lys Lys Leu Ala Val 
        115                 120                 125             


Thr Lys Pro Asn Asn Ile Lys Ser Met Phe Ile Ala Cys Ala Gly Lys 
    130                 135                 140                 


Lys Thr Ala Asp Lys Ala Val Asp Leu Ser Lys Asp Gly Leu Leu Gly 
145                 150                 155                 160 


Asp Ile Leu Gln Asp Leu Asn Thr Glu Thr Pro Gln Ile Thr Pro Pro 
                165                 170                 175     


Pro Val Met Ile Leu Lys Lys Lys Arg Ser Ile Gly Ala Ser Pro Asn 
            180                 185                 190         


Pro Phe Ser Val His Thr Ala Thr Ala Val Pro Ser Gly Lys Ile Ala 
        195                 200                 205             


Ser Pro Val Ser Arg Lys Glu Pro Pro Leu Thr Pro Val Pro Leu Lys 
    210                 215                 220                 


Arg Ala Glu Phe Ala Gly Asp Asp Val Gln Val Glu Ser Thr Glu Glu 
225                 230                 235                 240 


Glu Gln Glu Ser Gly Ala Met Glu Phe Glu Asp Gly Asp Phe Asp Glu 
                245                 250                 255     


Pro Met Glu Val Glu Glu Val Asp Leu Glu Pro Met Ala Ala Lys Ala 
            260                 265                 270         


Trp Asp Lys Glu Ser Glu Pro Ala Glu Glu Val Lys Gln Glu Ala Asp 
        275                 280                 285             


Ser Gly Lys Gly Thr Val Ser Tyr Leu Gly Ser Phe Leu Pro Asp Val 
    290                 295                 300                 


Ser Cys Trp Asp Ile Asp Gln Glu Gly Asp Ser Ser Phe Ser Val Gln 
305                 310                 315                 320 


Glu Val Gln Val Asp Ser Ser His Leu Pro Leu Val Lys Gly Ala Asp 
                325                 330                 335     


Glu Glu Gln Val Phe His Phe Tyr Trp Leu Asp Ala Tyr Glu Asp Gln 
            340                 345                 350         


Tyr Asn Gln Pro Gly Val Val Phe Leu Phe Gly Lys Val Trp Ile Glu 
        355                 360                 365             


Ser Ala Glu Thr His Val Ser Cys Cys Val Met Val Lys Asn Ile Glu 
    370                 375                 380                 


Arg Thr Leu Tyr Phe Leu Pro Arg Glu Met Lys Ile Asp Leu Asn Thr 
385                 390                 395                 400 


Gly Lys Glu Thr Gly Thr Pro Ile Ser Met Lys Asp Val Tyr Glu Glu 
                405                 410                 415     


Phe Asp Glu Lys Ile Ala Thr Lys Tyr Lys Ile Met Lys Phe Lys Ser 
            420                 425                 430         


Lys Pro Val Glu Lys Asn Tyr Ala Phe Glu Ile Pro Asp Val Pro Glu 
        435                 440                 445             


Lys Ser Glu Tyr Leu Glu Val Lys Tyr Ser Ala Glu Met Pro Gln Leu 
    450                 455                 460                 


Pro Gln Asp Leu Lys Gly Glu Thr Phe Ser His Val Phe Gly Thr Asn 
465                 470                 475                 480 


Thr Ser Ser Leu Glu Leu Phe Leu Met Asn Arg Lys Ile Lys Gly Pro 
                485                 490                 495     


Cys Trp Leu Glu Val Lys Ser Pro Gln Leu Leu Asn Gln Pro Val Ser 
            500                 505                 510         


Trp Cys Lys Val Glu Ala Met Ala Leu Lys Pro Asp Leu Val Asn Val 
        515                 520                 525             


Ile Lys Asp Val Ser Pro Pro Pro Leu Val Val Met Ala Phe Ser Met 
    530                 535                 540                 


Lys Thr Met Gln Asn Ala Lys Asn His Gln Asn Glu Ile Ile Ala Met 
545                 550                 555                 560 


Ala Ala Leu Val His His Ser Phe Ala Leu Asp Lys Ala Ala Pro Lys 
                565                 570                 575     


Pro Pro Phe Gln Ser His Phe Cys Val Val Ser Lys Pro Lys Asp Cys 
            580                 585                 590         


Ile Phe Pro Tyr Ala Phe Lys Glu Val Ile Glu Lys Lys Asn Val Lys 
        595                 600                 605             


Val Glu Val Ala Ala Thr Glu Arg Thr Leu Leu Gly Phe Phe Leu Ala 
    610                 615                 620                 


Lys Val His Lys Ile Asp Pro Asp Ile Ile Val Gly His Asn Ile Tyr 
625                 630                 635                 640 


Gly Phe Glu Leu Glu Val Leu Leu Gln Arg Ile Asn Val Cys Lys Ala 
                645                 650                 655     


Pro His Trp Ser Lys Ile Gly Arg Leu Lys Arg Ser Asn Met Pro Lys 
            660                 665                 670         


Leu Gly Gly Arg Ser Gly Phe Gly Glu Arg Asn Ala Thr Cys Gly Arg 
        675                 680                 685             


Met Ile Cys Asp Val Glu Ile Ser Ala Lys Glu Leu Ile Arg Cys Lys 
    690                 695                 700                 


Ser Tyr His Leu Ser Glu Leu Val Gln Gln Ile Leu Lys Thr Glu Arg 
705                 710                 715                 720 


Val Val Ile Pro Met Glu Asn Ile Gln Asn Met Tyr Ser Glu Ser Ser 
                725                 730                 735     


Gln Leu Leu Tyr Leu Leu Glu His Thr Trp Lys Asp Ala Lys Phe Ile 
            740                 745                 750         


Leu Gln Ile Met Cys Glu Leu Asn Val Leu Pro Leu Ala Leu Gln Ile 
        755                 760                 765             


Thr Asn Ile Ala Gly Asn Ile Met Ser Arg Thr Leu Met Gly Gly Arg 
    770                 775                 780                 


Ser Glu Arg Asn Glu Phe Leu Leu Leu His Ala Phe Tyr Glu Asn Asn 
785                 790                 795                 800 


Tyr Ile Val Pro Asp Lys Gln Ile Phe Arg Lys Pro Gln Gln Lys Leu 
                805                 810                 815     


Gly Asp Glu Asp Glu Glu Ile Asp Gly Asp Thr Asn Lys Tyr Lys Lys 
            820                 825                 830         


Gly Arg Lys Lys Ala Ala Tyr Ala Gly Gly Leu Val Leu Asp Pro Lys 
        835                 840                 845             


Val Gly Phe Tyr Asp Lys Phe Ile Leu Leu Leu Asp Phe Asn Ser Leu 
    850                 855                 860                 


Tyr Pro Ser Ile Ile Gln Glu Phe Asn Ile Cys Phe Thr Thr Val Gln 
865                 870                 875                 880 


Arg Val Ala Ser Glu Ala Gln Lys Val Thr Glu Asp Gly Glu Gln Glu 
                885                 890                 895     


Gln Ile Pro Glu Leu Pro Asp Pro Ser Leu Glu Met Gly Ile Leu Pro 
            900                 905                 910         


Arg Glu Ile Arg Lys Leu Val Glu Arg Arg Lys Gln Val Lys Gln Leu 
        915                 920                 925             


Met Lys Gln Gln Asp Leu Asn Pro Asp Leu Ile Leu Gln Tyr Asp Ile 
    930                 935                 940                 


Arg Gln Lys Ala Leu Lys Leu Thr Ala Asn Ser Met Tyr Gly Cys Leu 
945                 950                 955                 960 


Gly Phe Ser Tyr Ser Arg Phe Tyr Ala Lys Pro Leu Ala Ala Leu Val 
                965                 970                 975     


Thr Tyr Lys Gly Arg Glu Ile Leu Met His Thr Lys Glu Met Val Gln 
            980                 985                 990         


Lys Met Asn Leu Glu Val Ile Tyr  Gly Asp Thr Asp Ser  Ile Met Ile 
        995                 1000                 1005             


Asn Thr  Asn Ser Thr Asn Leu  Glu Glu Val Phe Lys  Leu Gly Asn 
    1010                 1015                 1020             


Lys Val  Lys Ser Glu Val Asn  Lys Leu Tyr Lys Leu  Leu Glu Ile 
    1025                 1030                 1035             


Asp Ile  Asp Gly Val Phe Lys  Ser Leu Leu Leu Leu  Lys Lys Lys 
    1040                 1045                 1050             


Lys Tyr  Ala Ala Leu Val Val  Glu Pro Thr Ser Asp  Gly Asn Tyr 
    1055                 1060                 1065             


Val Thr  Lys Gln Glu Leu Lys  Gly Leu Asp Ile Val  Arg Arg Asp 
    1070                 1075                 1080             


Trp Cys  Asp Leu Ala Lys Asp  Thr Gly Asn Phe Val  Ile Gly Gln 
    1085                 1090                 1095             


Ile Leu  Ser Asp Gln Ser Arg  Asp Thr Ile Val Glu  Asn Ile Gln 
    1100                 1105                 1110             


Lys Arg  Leu Ile Glu Ile Gly  Glu Asn Val Leu Asn  Gly Ser Val 
    1115                 1120                 1125             


Pro Val  Ser Gln Phe Glu Ile  Asn Lys Ala Leu Thr  Lys Asp Pro 
    1130                 1135                 1140             


Gln Asp  Tyr Pro Asp Lys Lys  Ser Leu Pro His Val  His Val Ala 
    1145                 1150                 1155             


Leu Trp  Ile Asn Ser Gln Gly  Gly Arg Lys Val Lys  Ala Gly Asp 
    1160                 1165                 1170             


Thr Val  Ser Tyr Val Ile Cys  Gln Asp Gly Ser Asn  Leu Thr Ala 
    1175                 1180                 1185             


Ser Gln  Arg Ala Tyr Ala Pro  Glu Gln Leu Gln Lys  Gln Asp Asn 
    1190                 1195                 1200             


Leu Thr  Ile Asp Thr Gln Tyr  Tyr Leu Ala Gln Gln  Ile His Pro 
    1205                 1210                 1215             


Val Val  Ala Arg Ile Cys Glu  Pro Ile Asp Gly Ile  Asp Ala Val 
    1220                 1225                 1230             


Leu Ile  Ala Thr Trp Leu Gly  Leu Asp Pro Thr Gln  Phe Arg Val 
    1235                 1240                 1245             


His His  Tyr His Lys Asp Glu  Glu Asn Asp Ala Leu  Leu Gly Gly 
    1250                 1255                 1260             


Pro Ala  Gln Leu Thr Asp Glu  Glu Lys Tyr Arg Asp  Cys Glu Arg 
    1265                 1270                 1275             


Phe Lys  Cys Pro Cys Pro Thr  Cys Gly Thr Glu Asn  Ile Tyr Asp 
    1280                 1285                 1290             


Asn Val  Phe Asp Gly Ser Gly  Thr Asp Met Glu Pro  Ser Leu Tyr 
    1295                 1300                 1305             


Arg Cys  Ser Asn Ile Asp Cys  Lys Ala Ser Pro Leu  Thr Phe Thr 
    1310                 1315                 1320             


Val Gln  Leu Ser Asn Lys Leu  Ile Met Asp Ile Arg  Arg Phe Ile 
    1325                 1330                 1335             


Lys Lys  Tyr Tyr Asp Gly Trp  Leu Ile Cys Glu Glu  Pro Thr Cys 
    1340                 1345                 1350             


Arg Asn  Arg Thr Arg His Leu  Pro Leu Gln Phe Ser  Arg Thr Gly 
    1355                 1360                 1365             


Pro Leu  Cys Pro Ala Cys Met  Lys Ala Thr Leu Gln  Pro Glu Tyr 
    1370                 1375                 1380             


Ser Asp  Lys Ser Leu Tyr Thr  Gln Leu Cys Phe Tyr  Arg Tyr Ile 
    1385                 1390                 1395             


Phe Asp  Ala Glu Cys Ala Leu  Glu Lys Leu Thr Thr  Asp His Glu 
    1400                 1405                 1410             


Lys Asp  Lys Leu Lys Lys Gln  Phe Phe Thr Pro Lys  Val Leu Gln 
    1415                 1420                 1425             


Asp Tyr  Arg Lys Leu Lys Asn  Thr Ala Glu Gln Phe  Leu Ser Arg 
    1430                 1435                 1440             


Ser Gly  Tyr Ser Glu Val Asn  Leu Ser Lys Leu Phe  Ala Gly Cys 
    1445                 1450                 1455             


Ala Val  Lys Ser 
    1460         


<210>  26
<211>  1148
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P35251
<309>  2016-09-07
<313>  (1)..(1148)

<400>  26

Met Asp Ile Arg Lys Phe Phe Gly Val Ile Pro Ser Gly Lys Lys Leu 
1               5                   10                  15      


Val Ser Glu Thr Val Lys Lys Asn Glu Lys Thr Lys Ser Asp Glu Glu 
            20                  25                  30          


Thr Leu Lys Ala Lys Lys Gly Ile Lys Glu Ile Lys Val Asn Ser Ser 
        35                  40                  45              


Arg Lys Glu Asp Asp Phe Lys Gln Lys Gln Pro Ser Lys Lys Lys Arg 
    50                  55                  60                  


Ile Ile Tyr Asp Ser Asp Ser Glu Ser Glu Glu Thr Leu Gln Val Lys 
65                  70                  75                  80  


Asn Ala Lys Lys Pro Pro Glu Lys Leu Pro Val Ser Ser Lys Pro Gly 
                85                  90                  95      


Lys Ile Ser Arg Gln Asp Pro Val Thr Tyr Ile Ser Glu Thr Asp Glu 
            100                 105                 110         


Glu Asp Asp Phe Met Cys Lys Lys Ala Ala Ser Lys Ser Lys Glu Asn 
        115                 120                 125             


Gly Arg Ser Thr Asn Ser His Leu Gly Thr Ser Asn Met Lys Lys Asn 
    130                 135                 140                 


Glu Glu Asn Thr Lys Thr Lys Asn Lys Pro Leu Ser Pro Ile Lys Leu 
145                 150                 155                 160 


Thr Pro Thr Ser Val Leu Asp Tyr Phe Gly Thr Gly Ser Val Gln Arg 
                165                 170                 175     


Ser Asn Lys Lys Met Val Ala Ser Lys Arg Lys Glu Leu Ser Gln Asn 
            180                 185                 190         


Thr Asp Glu Ser Gly Leu Asn Asp Glu Ala Ile Ala Lys Gln Leu Gln 
        195                 200                 205             


Leu Asp Glu Asp Ala Glu Leu Glu Arg Gln Leu His Glu Asp Glu Glu 
    210                 215                 220                 


Phe Ala Arg Thr Leu Ala Met Leu Asp Glu Glu Pro Lys Thr Lys Lys 
225                 230                 235                 240 


Ala Arg Lys Asp Thr Glu Ala Gly Glu Thr Phe Ser Ser Val Gln Ala 
                245                 250                 255     


Asn Leu Ser Lys Ala Glu Lys His Lys Tyr Pro His Lys Val Lys Thr 
            260                 265                 270         


Ala Gln Val Ser Asp Glu Arg Lys Ser Tyr Ser Pro Arg Lys Gln Ser 
        275                 280                 285             


Lys Tyr Glu Ser Ser Lys Glu Ser Gln Gln His Ser Lys Ser Ser Ala 
    290                 295                 300                 


Asp Lys Ile Gly Glu Val Ser Ser Pro Lys Ala Ser Ser Lys Leu Ala 
305                 310                 315                 320 


Ile Met Lys Arg Lys Glu Glu Ser Ser Tyr Lys Glu Ile Glu Pro Val 
                325                 330                 335     


Ala Ser Lys Arg Lys Glu Asn Ala Ile Lys Leu Lys Gly Glu Thr Lys 
            340                 345                 350         


Thr Pro Lys Lys Thr Lys Ser Ser Pro Ala Lys Lys Glu Ser Val Ser 
        355                 360                 365             


Pro Glu Asp Ser Glu Lys Lys Arg Thr Asn Tyr Gln Ala Tyr Arg Ser 
    370                 375                 380                 


Tyr Leu Asn Arg Glu Gly Pro Lys Ala Leu Gly Ser Lys Glu Ile Pro 
385                 390                 395                 400 


Lys Gly Ala Glu Asn Cys Leu Glu Gly Leu Ile Phe Val Ile Thr Gly 
                405                 410                 415     


Val Leu Glu Ser Ile Glu Arg Asp Glu Ala Lys Ser Leu Ile Glu Arg 
            420                 425                 430         


Tyr Gly Gly Lys Val Thr Gly Asn Val Ser Lys Lys Thr Asn Tyr Leu 
        435                 440                 445             


Val Met Gly Arg Asp Ser Gly Gln Ser Lys Ser Asp Lys Ala Ala Ala 
    450                 455                 460                 


Leu Gly Thr Lys Ile Ile Asp Glu Asp Gly Leu Leu Asn Leu Ile Arg 
465                 470                 475                 480 


Thr Met Pro Gly Lys Lys Ser Lys Tyr Glu Ile Ala Val Glu Thr Glu 
                485                 490                 495     


Met Lys Lys Glu Ser Lys Leu Glu Arg Thr Pro Gln Lys Asn Val Gln 
            500                 505                 510         


Gly Lys Arg Lys Ile Ser Pro Ser Lys Lys Glu Ser Glu Ser Lys Lys 
        515                 520                 525             


Ser Arg Pro Thr Ser Lys Arg Asp Ser Leu Ala Lys Thr Ile Lys Lys 
    530                 535                 540                 


Glu Thr Asp Val Phe Trp Lys Ser Leu Asp Phe Lys Glu Gln Val Ala 
545                 550                 555                 560 


Glu Glu Thr Ser Gly Asp Ser Lys Ala Arg Asn Leu Ala Asp Asp Ser 
                565                 570                 575     


Ser Glu Asn Lys Val Glu Asn Leu Leu Trp Val Asp Lys Tyr Lys Pro 
            580                 585                 590         


Thr Ser Leu Lys Thr Ile Ile Gly Gln Gln Gly Asp Gln Ser Cys Ala 
        595                 600                 605             


Asn Lys Leu Leu Arg Trp Leu Arg Asn Trp Gln Lys Ser Ser Ser Glu 
    610                 615                 620                 


Asp Lys Lys His Ala Ala Lys Phe Gly Lys Phe Ser Gly Lys Asp Asp 
625                 630                 635                 640 


Gly Ser Ser Phe Lys Ala Ala Leu Leu Ser Gly Pro Pro Gly Val Gly 
                645                 650                 655     


Lys Thr Thr Thr Ala Ser Leu Val Cys Gln Glu Leu Gly Tyr Ser Tyr 
            660                 665                 670         


Val Glu Leu Asn Ala Ser Asp Thr Arg Ser Lys Ser Ser Leu Lys Ala 
        675                 680                 685             


Ile Val Ala Glu Ser Leu Asn Asn Thr Ser Ile Lys Gly Phe Tyr Ser 
    690                 695                 700                 


Asn Gly Ala Ala Ser Ser Val Ser Thr Lys His Ala Leu Ile Met Asp 
705                 710                 715                 720 


Glu Val Asp Gly Met Ala Gly Asn Glu Asp Arg Gly Gly Ile Gln Glu 
                725                 730                 735     


Leu Ile Gly Leu Ile Lys His Thr Lys Ile Pro Ile Ile Cys Met Cys 
            740                 745                 750         


Asn Asp Arg Asn His Pro Lys Ile Arg Ser Leu Val His Tyr Cys Phe 
        755                 760                 765             


Asp Leu Arg Phe Gln Arg Pro Arg Val Glu Gln Ile Lys Gly Ala Met 
    770                 775                 780                 


Met Ser Ile Ala Phe Lys Glu Gly Leu Lys Ile Pro Pro Pro Ala Met 
785                 790                 795                 800 


Asn Glu Ile Ile Leu Gly Ala Asn Gln Asp Ile Arg Gln Val Leu His 
                805                 810                 815     


Asn Leu Ser Met Trp Cys Ala Arg Ser Lys Ala Leu Thr Tyr Asp Gln 
            820                 825                 830         


Ala Lys Ala Asp Ser His Arg Ala Lys Lys Asp Ile Lys Met Gly Pro 
        835                 840                 845             


Phe Asp Val Ala Arg Lys Val Phe Ala Ala Gly Glu Glu Thr Ala His 
    850                 855                 860                 


Met Ser Leu Val Asp Lys Ser Asp Leu Phe Phe His Asp Tyr Ser Ile 
865                 870                 875                 880 


Ala Pro Leu Phe Val Gln Glu Asn Tyr Ile His Val Lys Pro Val Ala 
                885                 890                 895     


Ala Gly Gly Asp Met Lys Lys His Leu Met Leu Leu Ser Arg Ala Ala 
            900                 905                 910         


Asp Ser Ile Cys Asp Gly Asp Leu Val Asp Ser Gln Ile Arg Ser Lys 
        915                 920                 925             


Gln Asn Trp Ser Leu Leu Pro Ala Gln Ala Ile Tyr Ala Ser Val Leu 
    930                 935                 940                 


Pro Gly Glu Leu Met Arg Gly Tyr Met Thr Gln Phe Pro Thr Phe Pro 
945                 950                 955                 960 


Ser Trp Leu Gly Lys His Ser Ser Thr Gly Lys His Asp Arg Ile Val 
                965                 970                 975     


Gln Asp Leu Ala Leu His Met Ser Leu Arg Thr Tyr Ser Ser Lys Arg 
            980                 985                 990         


Thr Val Asn Met Asp Tyr Leu Ser  Leu Leu Arg Asp Ala  Leu Val Gln 
        995                 1000                 1005             


Pro Leu  Thr Ser Gln Gly Val  Asp Gly Val Gln Asp  Val Val Ala 
    1010                 1015                 1020             


Leu Met  Asp Thr Tyr Tyr Leu  Met Lys Glu Asp Phe  Glu Asn Ile 
    1025                 1030                 1035             


Met Glu  Ile Ser Ser Trp Gly  Gly Lys Pro Ser Pro  Phe Ser Lys 
    1040                 1045                 1050             


Leu Asp  Pro Lys Val Lys Ala  Ala Phe Thr Arg Ala  Tyr Asn Lys 
    1055                 1060                 1065             


Glu Ala  His Leu Thr Pro Tyr  Ser Leu Gln Ala Ile  Lys Ala Ser 
    1070                 1075                 1080             


Arg His  Ser Thr Ser Pro Ser  Leu Asp Ser Glu Tyr  Asn Glu Glu 
    1085                 1090                 1095             


Leu Asn  Glu Asp Asp Ser Gln  Ser Asp Glu Lys Asp  Gln Asp Ala 
    1100                 1105                 1110             


Ile Glu  Thr Asp Ala Met Ile  Lys Lys Lys Thr Lys  Ser Ser Lys 
    1115                 1120                 1125             


Pro Ser  Lys Pro Glu Lys Asp  Lys Glu Pro Arg Lys  Gly Lys Gly 
    1130                 1135                 1140             


Lys Ser  Ser Lys Lys 
    1145             


<210>  27
<211>  2813
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q12802
<309>  2016-09-07
<313>  (1)..(2813)

<400>  27

Met Lys Leu Asn Pro Gln Gln Ala Pro Leu Tyr Gly Asp Cys Val Val 
1               5                   10                  15      


Thr Val Leu Leu Ala Glu Glu Asp Lys Ala Glu Asp Asp Val Val Phe 
            20                  25                  30          


Tyr Leu Val Phe Leu Gly Ser Thr Leu Arg His Cys Thr Ser Thr Arg 
        35                  40                  45              


Lys Val Ser Ser Asp Thr Leu Glu Thr Ile Ala Pro Gly His Asp Cys 
    50                  55                  60                  


Cys Glu Thr Val Lys Val Gln Leu Cys Ala Ser Lys Glu Gly Leu Pro 
65                  70                  75                  80  


Val Phe Val Val Ala Glu Glu Asp Phe His Phe Val Gln Asp Glu Ala 
                85                  90                  95      


Tyr Asp Ala Ala Gln Phe Leu Ala Thr Ser Ala Gly Asn Gln Gln Ala 
            100                 105                 110         


Leu Asn Phe Thr Arg Phe Leu Asp Gln Ser Gly Pro Pro Ser Gly Asp 
        115                 120                 125             


Val Asn Ser Leu Asp Lys Lys Leu Val Leu Ala Phe Arg His Leu Lys 
    130                 135                 140                 


Leu Pro Thr Glu Trp Asn Val Leu Gly Thr Asp Gln Ser Leu His Asp 
145                 150                 155                 160 


Ala Gly Pro Arg Glu Thr Leu Met His Phe Ala Val Arg Leu Gly Leu 
                165                 170                 175     


Leu Arg Leu Thr Trp Phe Leu Leu Gln Lys Pro Gly Gly Arg Gly Ala 
            180                 185                 190         


Leu Ser Ile His Asn Gln Glu Gly Ala Thr Pro Val Ser Leu Ala Leu 
        195                 200                 205             


Glu Arg Gly Tyr His Lys Leu His Gln Leu Leu Thr Glu Glu Asn Ala 
    210                 215                 220                 


Gly Glu Pro Asp Ser Trp Ser Ser Leu Ser Tyr Glu Ile Pro Tyr Gly 
225                 230                 235                 240 


Asp Cys Ser Val Arg His His Arg Glu Leu Asp Ile Tyr Thr Leu Thr 
                245                 250                 255     


Ser Glu Ser Asp Ser His His Glu His Pro Phe Pro Gly Asp Gly Cys 
            260                 265                 270         


Thr Gly Pro Ile Phe Lys Leu Met Asn Ile Gln Gln Gln Leu Met Lys 
        275                 280                 285             


Thr Asn Leu Lys Gln Met Asp Ser Leu Met Pro Leu Met Met Thr Ala 
    290                 295                 300                 


Gln Asp Pro Ser Ser Ala Pro Glu Thr Asp Gly Gln Phe Leu Pro Cys 
305                 310                 315                 320 


Ala Pro Glu Pro Thr Asp Pro Gln Arg Leu Ser Ser Ser Glu Glu Thr 
                325                 330                 335     


Glu Ser Thr Gln Cys Cys Pro Gly Ser Pro Val Ala Gln Thr Glu Ser 
            340                 345                 350         


Pro Cys Asp Leu Ser Ser Ile Val Glu Glu Glu Asn Thr Asp Arg Ser 
        355                 360                 365             


Cys Arg Lys Lys Asn Lys Gly Val Glu Arg Lys Gly Glu Glu Val Glu 
    370                 375                 380                 


Pro Ala Pro Ile Val Asp Ser Gly Thr Val Ser Asp Gln Asp Ser Cys 
385                 390                 395                 400 


Leu Gln Ser Leu Pro Asp Cys Gly Val Lys Gly Thr Glu Gly Leu Ser 
                405                 410                 415     


Ser Cys Gly Asn Arg Asn Glu Glu Thr Gly Thr Lys Ser Ser Gly Met 
            420                 425                 430         


Pro Thr Asp Gln Glu Ser Leu Ser Ser Gly Asp Ala Val Leu Gln Arg 
        435                 440                 445             


Asp Leu Val Met Glu Pro Gly Thr Ala Gln Tyr Ser Ser Gly Gly Glu 
    450                 455                 460                 


Leu Gly Gly Ile Ser Thr Thr Asn Val Ser Thr Pro Asp Thr Ala Gly 
465                 470                 475                 480 


Glu Met Glu His Gly Leu Met Asn Pro Asp Ala Thr Val Trp Lys Asn 
                485                 490                 495     


Val Leu Gln Gly Gly Glu Ser Thr Lys Glu Arg Phe Glu Asn Ser Asn 
            500                 505                 510         


Ile Gly Thr Ala Gly Ala Ser Asp Val His Val Thr Ser Lys Pro Val 
        515                 520                 525             


Asp Lys Ile Ser Val Pro Asn Cys Ala Pro Ala Ala Ser Ser Leu Asp 
    530                 535                 540                 


Gly Asn Lys Pro Ala Glu Ser Ser Leu Ala Phe Ser Asn Glu Glu Thr 
545                 550                 555                 560 


Ser Thr Glu Lys Thr Ala Glu Thr Glu Thr Ser Arg Ser Arg Glu Glu 
                565                 570                 575     


Ser Ala Asp Ala Pro Val Asp Gln Asn Ser Val Val Ile Pro Ala Ala 
            580                 585                 590         


Ala Lys Asp Lys Ile Ser Asp Gly Leu Glu Pro Tyr Thr Leu Leu Ala 
        595                 600                 605             


Ala Gly Ile Gly Glu Ala Met Ser Pro Ser Asp Leu Ala Leu Leu Gly 
    610                 615                 620                 


Leu Glu Glu Asp Val Met Pro His Gln Asn Ser Glu Thr Asn Ser Ser 
625                 630                 635                 640 


His Ala Gln Ser Gln Lys Gly Lys Ser Ser Pro Ile Cys Ser Thr Thr 
                645                 650                 655     


Gly Asp Asp Lys Leu Cys Ala Asp Ser Ala Cys Gln Gln Asn Thr Val 
            660                 665                 670         


Thr Ser Ser Gly Asp Leu Val Ala Lys Leu Cys Asp Asn Ile Val Ser 
        675                 680                 685             


Glu Ser Glu Ser Thr Thr Ala Arg Gln Pro Ser Ser Gln Asp Pro Pro 
    690                 695                 700                 


Asp Ala Ser His Cys Glu Asp Pro Gln Ala His Thr Val Thr Ser Asp 
705                 710                 715                 720 


Pro Val Arg Asp Thr Gln Glu Arg Ala Asp Phe Cys Pro Phe Lys Val 
                725                 730                 735     


Val Asp Asn Lys Gly Gln Arg Lys Asp Val Lys Leu Asp Lys Pro Leu 
            740                 745                 750         


Thr Asn Met Leu Glu Val Val Ser His Pro His Pro Val Val Pro Lys 
        755                 760                 765             


Met Glu Lys Glu Leu Val Pro Asp Gln Ala Val Ile Ser Asp Ser Thr 
    770                 775                 780                 


Phe Ser Leu Ala Asn Ser Pro Gly Ser Glu Ser Val Thr Lys Asp Asp 
785                 790                 795                 800 


Ala Leu Ser Phe Val Pro Ser Gln Lys Glu Lys Gly Thr Ala Thr Pro 
                805                 810                 815     


Glu Leu His Thr Ala Thr Asp Tyr Arg Asp Gly Pro Asp Gly Asn Ser 
            820                 825                 830         


Asn Glu Pro Asp Thr Arg Pro Leu Glu Asp Arg Ala Val Gly Leu Ser 
        835                 840                 845             


Thr Ser Ser Thr Ala Ala Glu Leu Gln His Gly Met Gly Asn Thr Ser 
    850                 855                 860                 


Leu Thr Gly Leu Gly Gly Glu His Glu Gly Pro Ala Pro Pro Ala Ile 
865                 870                 875                 880 


Pro Glu Ala Leu Asn Ile Lys Gly Asn Thr Asp Ser Ser Leu Gln Ser 
                885                 890                 895     


Val Gly Lys Ala Thr Leu Ala Leu Asp Ser Val Leu Thr Glu Glu Gly 
            900                 905                 910         


Lys Leu Leu Val Val Ser Glu Ser Ser Ala Ala Gln Glu Gln Asp Lys 
        915                 920                 925             


Asp Lys Ala Val Thr Cys Ser Ser Ile Lys Glu Asn Ala Leu Ser Ser 
    930                 935                 940                 


Gly Thr Leu Gln Glu Glu Gln Arg Thr Pro Pro Pro Gly Gln Asp Thr 
945                 950                 955                 960 


Gln Gln Phe His Glu Lys Ser Ile Ser Ala Asp Cys Ala Lys Asp Lys 
                965                 970                 975     


Ala Leu Gln Leu Ser Asn Ser Pro Gly Ala Ser Ser Ala Phe Leu Lys 
            980                 985                 990         


Ala Glu Thr Glu His Asn Lys Glu  Val Ala Pro Gln Val  Ser Leu Leu 
        995                 1000                 1005             


Thr Gln  Gly Gly Ala Ala Gln  Ser Leu Val Pro Pro  Gly Ala Ser 
    1010                 1015                 1020             


Leu Ala  Thr Glu Ser Arg Gln  Glu Ala Leu Gly Ala  Glu His Asn 
    1025                 1030                 1035             


Ser Ser  Ala Leu Leu Pro Cys  Leu Leu Pro Asp Gly  Ser Asp Gly 
    1040                 1045                 1050             


Ser Asp  Ala Leu Asn Cys Ser  Gln Pro Ser Pro Leu  Asp Val Gly 
    1055                 1060                 1065             


Val Lys  Asn Thr Gln Ser Gln  Gly Lys Thr Ser Ala  Cys Glu Val 
    1070                 1075                 1080             


Ser Gly  Asp Val Thr Val Asp  Val Thr Gly Val Asn  Ala Leu Gln 
    1085                 1090                 1095             


Gly Met  Ala Glu Pro Arg Arg  Glu Asn Ile Ser His  Asn Thr Gln 
    1100                 1105                 1110             


Asp Ile  Leu Ile Pro Asn Val  Leu Leu Ser Gln Glu  Lys Asn Ala 
    1115                 1120                 1125             


Val Leu  Gly Leu Pro Val Ala  Leu Gln Asp Lys Ala  Val Thr Asp 
    1130                 1135                 1140             


Pro Gln  Gly Val Gly Thr Pro  Glu Met Ile Pro Leu  Asp Trp Glu 
    1145                 1150                 1155             


Lys Gly  Lys Leu Glu Gly Ala  Asp His Ser Cys Thr  Met Gly Asp 
    1160                 1165                 1170             


Ala Glu  Glu Ala Gln Ile Asp  Asp Glu Ala His Pro  Val Leu Leu 
    1175                 1180                 1185             


Gln Pro  Val Ala Lys Glu Leu  Pro Thr Asp Met Glu  Leu Ser Ala 
    1190                 1195                 1200             


His Asp  Asp Gly Ala Pro Ala  Gly Val Arg Glu Val  Met Arg Ala 
    1205                 1210                 1215             


Pro Pro  Ser Gly Arg Glu Arg  Ser Thr Pro Ser Leu  Pro Cys Met 
    1220                 1225                 1230             


Val Ser  Ala Gln Asp Ala Pro  Leu Pro Lys Gly Ala  Asp Leu Ile 
    1235                 1240                 1245             


Glu Glu  Ala Ala Ser Arg Ile  Val Asp Ala Val Ile  Glu Gln Val 
    1250                 1255                 1260             


Lys Ala  Ala Gly Ala Leu Leu  Thr Glu Gly Glu Ala  Cys His Met 
    1265                 1270                 1275             


Ser Leu  Ser Ser Pro Glu Leu  Gly Pro Leu Thr Lys  Gly Leu Glu 
    1280                 1285                 1290             


Ser Ala  Phe Thr Glu Lys Val  Ser Thr Phe Pro Pro  Gly Glu Ser 
    1295                 1300                 1305             


Leu Pro  Met Gly Ser Thr Pro  Glu Glu Ala Thr Gly  Ser Leu Ala 
    1310                 1315                 1320             


Gly Cys  Phe Ala Gly Arg Glu  Glu Pro Glu Lys Ile  Ile Leu Pro 
    1325                 1330                 1335             


Val Gln  Gly Pro Glu Pro Ala  Ala Glu Met Pro Asp  Val Lys Ala 
    1340                 1345                 1350             


Glu Asp  Glu Val Asp Phe Arg  Ala Ser Ser Ile Ser  Glu Glu Val 
    1355                 1360                 1365             


Ala Val  Gly Ser Ile Ala Ala  Thr Leu Lys Met Lys  Gln Gly Pro 
    1370                 1375                 1380             


Met Thr  Gln Ala Ile Asn Arg  Glu Asn Trp Cys Thr  Ile Glu Pro 
    1385                 1390                 1395             


Cys Pro  Asp Ala Ala Ser Leu  Leu Ala Ser Lys Gln  Ser Pro Glu 
    1400                 1405                 1410             


Cys Glu  Asn Phe Leu Asp Val  Gly Leu Gly Arg Glu  Cys Thr Ser 
    1415                 1420                 1425             


Lys Gln  Gly Val Leu Lys Arg  Glu Ser Gly Ser Asp  Ser Asp Leu 
    1430                 1435                 1440             


Phe His  Ser Pro Ser Asp Asp  Met Asp Ser Ile Ile  Phe Pro Lys 
    1445                 1450                 1455             


Pro Glu  Glu Glu His Leu Ala  Cys Asp Ile Thr Gly  Ser Ser Ser 
    1460                 1465                 1470             


Ser Thr  Asp Asp Thr Ala Ser  Leu Asp Arg His Ser  Ser His Gly 
    1475                 1480                 1485             


Ser Asp  Val Ser Leu Ser Gln  Ile Leu Lys Pro Asn  Arg Ser Arg 
    1490                 1495                 1500             


Asp Arg  Gln Ser Leu Asp Gly  Phe Tyr Ser His Gly  Met Gly Ala 
    1505                 1510                 1515             


Glu Gly  Arg Glu Ser Glu Ser  Glu Pro Ala Asp Pro  Gly Asp Val 
    1520                 1525                 1530             


Glu Glu  Glu Glu Met Asp Ser  Ile Thr Glu Val Pro  Ala Asn Cys 
    1535                 1540                 1545             


Ser Val  Leu Arg Ser Ser Met  Arg Ser Leu Ser Pro  Phe Arg Arg 
    1550                 1555                 1560             


His Ser  Trp Gly Pro Gly Lys  Asn Ala Ala Ser Asp  Ala Glu Met 
    1565                 1570                 1575             


Asn His  Arg Ser Ser Met Arg  Val Leu Gly Asp Val  Val Arg Arg 
    1580                 1585                 1590             


Pro Pro  Ile His Arg Arg Ser  Phe Ser Leu Glu Gly  Leu Thr Gly 
    1595                 1600                 1605             


Gly Ala  Gly Val Gly Asn Lys  Pro Ser Ser Ser Leu  Glu Val Ser 
    1610                 1615                 1620             


Ser Ala  Asn Ala Glu Glu Leu  Arg His Pro Phe Ser  Gly Glu Glu 
    1625                 1630                 1635             


Arg Val  Asp Ser Leu Val Ser  Leu Ser Glu Glu Asp  Leu Glu Ser 
    1640                 1645                 1650             


Asp Gln  Arg Glu His Arg Met  Phe Asp Gln Gln Ile  Cys His Arg 
    1655                 1660                 1665             


Ser Lys  Gln Gln Gly Phe Asn  Tyr Cys Thr Ser Ala  Ile Ser Ser 
    1670                 1675                 1680             


Pro Leu  Thr Lys Ser Ile Ser  Leu Met Thr Ile Ser  His Pro Gly 
    1685                 1690                 1695             


Leu Asp  Asn Ser Arg Pro Phe  His Ser Thr Phe His  Asn Thr Ser 
    1700                 1705                 1710             


Ala Asn  Leu Thr Glu Ser Ile  Thr Glu Glu Asn Tyr  Asn Phe Leu 
    1715                 1720                 1725             


Pro His  Ser Pro Ser Lys Lys  Asp Ser Glu Trp Lys  Ser Gly Thr 
    1730                 1735                 1740             


Lys Val  Ser Arg Thr Phe Ser  Tyr Ile Lys Asn Lys  Met Ser Ser 
    1745                 1750                 1755             


Ser Lys  Lys Ser Lys Glu Lys  Glu Lys Glu Lys Asp  Lys Ile Lys 
    1760                 1765                 1770             


Glu Lys  Glu Lys Asp Ser Lys  Asp Lys Glu Lys Asp  Lys Lys Thr 
    1775                 1780                 1785             


Val Asn  Gly His Thr Phe Ser  Ser Ile Pro Val Val  Gly Pro Ile 
    1790                 1795                 1800             


Ser Cys  Ser Gln Cys Met Lys  Pro Phe Thr Asn Lys  Asp Ala Tyr 
    1805                 1810                 1815             


Thr Cys  Ala Asn Cys Ser Ala  Phe Val His Lys Gly  Cys Arg Glu 
    1820                 1825                 1830             


Ser Leu  Ala Ser Cys Ala Lys  Val Lys Met Lys Gln  Pro Lys Gly 
    1835                 1840                 1845             


Ser Leu  Gln Ala His Asp Thr  Ser Ser Leu Pro Thr  Val Ile Met 
    1850                 1855                 1860             


Arg Asn  Lys Pro Ser Gln Pro  Lys Glu Arg Pro Arg  Ser Ala Val 
    1865                 1870                 1875             


Leu Leu  Val Asp Glu Thr Ala  Thr Thr Pro Ile Phe  Ala Asn Arg 
    1880                 1885                 1890             


Arg Ser  Gln Gln Ser Val Ser  Leu Ser Lys Ser Val  Ser Ile Gln 
    1895                 1900                 1905             


Asn Ile  Thr Gly Val Gly Asn  Asp Glu Asn Met Ser  Asn Thr Trp 
    1910                 1915                 1920             


Lys Phe  Leu Ser His Ser Thr  Asp Ser Leu Asn Lys  Ile Ser Lys 
    1925                 1930                 1935             


Val Asn  Glu Ser Thr Glu Ser  Leu Thr Asp Glu Gly  Val Gly Thr 
    1940                 1945                 1950             


Asp Met  Asn Glu Gly Gln Leu  Leu Gly Asp Phe Glu  Ile Glu Ser 
    1955                 1960                 1965             


Lys Gln  Leu Glu Ala Glu Ser  Trp Ser Arg Ile Ile  Asp Ser Lys 
    1970                 1975                 1980             


Phe Leu  Lys Gln Gln Lys Lys  Asp Val Val Lys Arg  Gln Glu Val 
    1985                 1990                 1995             


Ile Tyr  Glu Leu Met Gln Thr  Glu Phe His His Val  Arg Thr Leu 
    2000                 2005                 2010             


Lys Ile  Met Ser Gly Val Tyr  Ser Gln Gly Met Met  Ala Asp Leu 
    2015                 2020                 2025             


Leu Phe  Glu Gln Gln Met Val  Glu Lys Leu Phe Pro  Cys Leu Asp 
    2030                 2035                 2040             


Glu Leu  Ile Ser Ile His Ser  Gln Phe Phe Gln Arg  Ile Leu Glu 
    2045                 2050                 2055             


Arg Lys  Lys Glu Ser Leu Val  Asp Lys Ser Glu Lys  Asn Phe Leu 
    2060                 2065                 2070             


Ile Lys  Arg Ile Gly Asp Val  Leu Val Asn Gln Phe  Ser Gly Glu 
    2075                 2080                 2085             


Asn Ala  Glu Arg Leu Lys Lys  Thr Tyr Gly Lys Phe  Cys Gly Gln 
    2090                 2095                 2100             


His Asn  Gln Ser Val Asn Tyr  Phe Lys Asp Leu Tyr  Ala Lys Asp 
    2105                 2110                 2115             


Lys Arg  Phe Gln Ala Phe Val  Lys Lys Lys Met Ser  Ser Ser Val 
    2120                 2125                 2130             


Val Arg  Arg Leu Gly Ile Pro  Glu Cys Ile Leu Leu  Val Thr Gln 
    2135                 2140                 2145             


Arg Ile  Thr Lys Tyr Pro Val  Leu Phe Gln Arg Ile  Leu Gln Cys 
    2150                 2155                 2160             


Thr Lys  Asp Asn Glu Val Glu  Gln Glu Asp Leu Ala  Gln Ser Leu 
    2165                 2170                 2175             


Ser Leu  Val Lys Asp Val Ile  Gly Ala Val Asp Ser  Lys Val Ala 
    2180                 2185                 2190             


Ser Tyr  Glu Lys Lys Val Arg  Leu Asn Glu Ile Tyr  Thr Lys Thr 
    2195                 2200                 2205             


Asp Ser  Lys Ser Ile Met Arg  Met Lys Ser Gly Gln  Met Phe Ala 
    2210                 2215                 2220             


Lys Glu  Asp Leu Lys Arg Lys  Lys Leu Val Arg Asp  Gly Ser Val 
    2225                 2230                 2235             


Phe Leu  Lys Asn Ala Ala Gly  Arg Leu Lys Glu Val  Gln Ala Val 
    2240                 2245                 2250             


Leu Leu  Thr Asp Ile Leu Val  Phe Leu Gln Glu Lys  Asp Gln Lys 
    2255                 2260                 2265             


Tyr Ile  Phe Ala Ser Leu Asp  Gln Lys Ser Thr Val  Ile Ser Leu 
    2270                 2275                 2280             


Lys Lys  Leu Ile Val Arg Glu  Val Ala His Glu Glu  Lys Gly Leu 
    2285                 2290                 2295             


Phe Leu  Ile Ser Met Gly Met  Thr Asp Pro Glu Met  Val Glu Val 
    2300                 2305                 2310             


His Ala  Ser Ser Lys Glu Glu  Arg Asn Ser Trp Ile  Gln Ile Ile 
    2315                 2320                 2325             


Gln Asp  Thr Ile Asn Thr Leu  Asn Arg Asp Glu Asp  Glu Gly Ile 
    2330                 2335                 2340             


Pro Ser  Glu Asn Glu Glu Glu  Lys Lys Met Leu Asp  Thr Arg Ala 
    2345                 2350                 2355             


Arg Glu  Leu Lys Glu Gln Leu  His Gln Lys Asp Gln  Lys Ile Leu 
    2360                 2365                 2370             


Leu Leu  Leu Glu Glu Lys Glu  Met Ile Phe Arg Asp  Met Ala Glu 
    2375                 2380                 2385             


Cys Ser  Thr Pro Leu Pro Glu  Asp Cys Ser Pro Thr  His Ser Pro 
    2390                 2395                 2400             


Arg Val  Leu Phe Arg Ser Asn  Thr Glu Glu Ala Leu  Lys Gly Gly 
    2405                 2410                 2415             


Pro Leu  Met Lys Ser Ala Ile  Asn Glu Val Glu Ile  Leu Gln Gly 
    2420                 2425                 2430             


Leu Val  Ser Gly Asn Leu Gly  Gly Thr Leu Gly Pro  Thr Val Ser 
    2435                 2440                 2445             


Ser Pro  Ile Glu Gln Asp Val  Val Gly Pro Val Ser  Leu Pro Arg 
    2450                 2455                 2460             


Arg Ala  Glu Thr Phe Gly Gly  Phe Asp Ser His Gln  Met Asn Ala 
    2465                 2470                 2475             


Ser Lys  Gly Gly Glu Lys Glu  Glu Gly Asp Asp Gly  Gln Asp Leu 
    2480                 2485                 2490             


Arg Arg  Thr Glu Ser Asp Ser  Gly Leu Lys Lys Gly  Gly Asn Ala 
    2495                 2500                 2505             


Asn Leu  Val Phe Met Leu Lys  Arg Asn Ser Glu Gln  Val Val Gln 
    2510                 2515                 2520             


Ser Val  Val His Leu Tyr Glu  Leu Leu Ser Ala Leu  Gln Gly Val 
    2525                 2530                 2535             


Val Leu  Gln Gln Asp Ser Tyr  Ile Glu Asp Gln Lys  Leu Val Leu 
    2540                 2545                 2550             


Ser Glu  Arg Ala Leu Thr Arg  Ser Leu Ser Arg Pro  Ser Ser Leu 
    2555                 2560                 2565             


Ile Glu  Gln Glu Lys Gln Arg  Ser Leu Glu Lys Gln  Arg Gln Asp 
    2570                 2575                 2580             


Leu Ala  Asn Leu Gln Lys Gln  Gln Ala Gln Tyr Leu  Glu Glu Lys 
    2585                 2590                 2595             


Arg Arg  Arg Glu Arg Glu Trp  Glu Ala Arg Glu Arg  Glu Leu Arg 
    2600                 2605                 2610             


Glu Arg  Glu Ala Leu Leu Ala  Gln Arg Glu Glu Glu  Val Gln Gln 
    2615                 2620                 2625             


Gly Gln  Gln Asp Leu Glu Lys  Glu Arg Glu Glu Leu  Gln Gln Lys 
    2630                 2635                 2640             


Lys Gly  Thr Tyr Gln Tyr Asp  Leu Glu Arg Leu Arg  Ala Ala Gln 
    2645                 2650                 2655             


Lys Gln  Leu Glu Arg Glu Gln  Glu Gln Leu Arg Arg  Glu Ala Glu 
    2660                 2665                 2670             


Arg Leu  Ser Gln Arg Gln Thr  Glu Arg Asp Leu Cys  Gln Val Ser 
    2675                 2680                 2685             


His Pro  His Thr Lys Leu Met  Arg Ile Pro Ser Phe  Phe Pro Ser 
    2690                 2695                 2700             


Pro Glu  Glu Pro Pro Ser Pro  Ser Ala Pro Ser Ile  Ala Lys Ser 
    2705                 2710                 2715             


Gly Ser  Leu Asp Ser Glu Leu  Ser Val Ser Pro Lys  Arg Asn Ser 
    2720                 2725                 2730             


Ile Ser  Arg Thr His Lys Asp  Lys Gly Pro Phe His  Ile Leu Ser 
    2735                 2740                 2745             


Ser Thr  Ser Gln Thr Asn Lys  Gly Pro Glu Gly Gln  Ser Gln Ala 
    2750                 2755                 2760             


Pro Ala  Ser Thr Ser Ala Ser  Thr Arg Leu Phe Gly  Leu Thr Lys 
    2765                 2770                 2775             


Pro Lys  Glu Lys Lys Glu Lys  Lys Lys Lys Asn Lys  Thr Ser Arg 
    2780                 2785                 2790             


Ser Gln  Pro Gly Asp Gly Pro  Ala Ser Glu Val Ser  Ala Glu Gly 
    2795                 2800                 2805             


Glu Glu  Ile Phe Cys 
    2810             


<210>  28
<211>  4834
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O95714
<309>  2005-09-13
<313>  (1)..(4834)

<400>  28

Met Pro Ser Glu Ser Phe Cys Leu Ala Ala Gln Ala Arg Leu Asp Ser 
1               5                   10                  15      


Lys Trp Leu Lys Thr Asp Ile Gln Leu Ala Phe Thr Arg Asp Gly Leu 
            20                  25                  30          


Cys Gly Leu Trp Asn Glu Met Val Lys Asp Gly Glu Ile Val Tyr Thr 
        35                  40                  45              


Gly Thr Glu Ser Thr Gln Asn Gly Glu Leu Pro Pro Arg Lys Asp Asp 
    50                  55                  60                  


Ser Val Glu Pro Ser Gly Thr Lys Lys Glu Asp Leu Asn Asp Lys Glu 
65                  70                  75                  80  


Lys Lys Asp Glu Glu Glu Thr Pro Ala Pro Ile Tyr Arg Ala Lys Ser 
                85                  90                  95      


Ile Leu Asp Ser Trp Val Trp Gly Lys Gln Pro Asp Val Asn Glu Leu 
            100                 105                 110         


Lys Glu Cys Leu Ser Val Leu Val Lys Glu Gln Gln Ala Leu Ala Val 
        115                 120                 125             


Gln Ser Ala Thr Thr Thr Leu Ser Ala Leu Arg Leu Lys Gln Arg Leu 
    130                 135                 140                 


Val Ile Leu Glu Arg Tyr Phe Ile Ala Leu Asn Arg Thr Val Phe Gln 
145                 150                 155                 160 


Glu Asn Val Lys Val Lys Trp Lys Ser Ser Gly Ile Ser Leu Pro Pro 
                165                 170                 175     


Val Asp Lys Lys Ser Ser Arg Pro Ala Gly Lys Gly Val Glu Gly Leu 
            180                 185                 190         


Ala Arg Val Gly Ser Arg Ala Ala Leu Ser Phe Ala Phe Ala Phe Leu 
        195                 200                 205             


Arg Arg Ala Trp Arg Ser Gly Glu Asp Ala Asp Leu Cys Ser Glu Leu 
    210                 215                 220                 


Leu Gln Glu Ser Leu Asp Ala Leu Arg Ala Leu Pro Glu Ala Ser Leu 
225                 230                 235                 240 


Phe Asp Glu Ser Thr Val Ser Ser Val Trp Leu Glu Val Val Glu Arg 
                245                 250                 255     


Ala Thr Arg Phe Leu Arg Ser Val Val Thr Gly Asp Val His Gly Thr 
            260                 265                 270         


Pro Ala Thr Lys Gly Pro Gly Ser Ile Pro Leu Gln Asp Gln His Leu 
        275                 280                 285             


Ala Leu Ala Ile Leu Leu Glu Leu Ala Val Gln Arg Gly Thr Leu Ser 
    290                 295                 300                 


Gln Met Leu Ser Ala Ile Leu Leu Leu Leu Gln Leu Trp Asp Ser Gly 
305                 310                 315                 320 


Ala Gln Glu Thr Asp Asn Glu Arg Ser Ala Gln Gly Thr Ser Ala Pro 
                325                 330                 335     


Leu Leu Pro Leu Leu Gln Arg Phe Gln Ser Ile Ile Cys Arg Lys Asp 
            340                 345                 350         


Ala Pro His Ser Glu Gly Asp Met His Leu Leu Ser Gly Pro Leu Ser 
        355                 360                 365             


Pro Asn Glu Ser Phe Leu Arg Tyr Leu Thr Leu Pro Gln Asp Asn Glu 
    370                 375                 380                 


Leu Ala Ile Asp Leu Arg Gln Thr Ala Val Val Val Met Ala His Leu 
385                 390                 395                 400 


Asp Arg Leu Ala Thr Pro Cys Met Pro Pro Leu Cys Ser Ser Pro Thr 
                405                 410                 415     


Ser His Lys Gly Ser Leu Gln Glu Val Ile Gly Trp Gly Leu Ile Gly 
            420                 425                 430         


Trp Lys Tyr Tyr Ala Asn Val Ile Gly Pro Ile Gln Cys Glu Gly Leu 
        435                 440                 445             


Ala Asn Leu Gly Val Thr Gln Ile Ala Cys Ala Glu Lys Arg Phe Leu 
    450                 455                 460                 


Ile Leu Ser Arg Asn Gly Arg Val Tyr Thr Gln Ala Tyr Asn Ser Asp 
465                 470                 475                 480 


Thr Leu Ala Pro Gln Leu Val Gln Gly Leu Ala Ser Arg Asn Ile Val 
                485                 490                 495     


Lys Ile Ala Ala His Ser Asp Gly His His Tyr Leu Ala Leu Ala Ala 
            500                 505                 510         


Thr Gly Glu Val Tyr Ser Trp Gly Cys Gly Asp Gly Gly Arg Leu Gly 
        515                 520                 525             


His Gly Asp Thr Val Pro Leu Glu Glu Pro Lys Val Ile Ser Ala Phe 
    530                 535                 540                 


Ser Gly Lys Gln Ala Gly Lys His Val Val His Ile Ala Cys Gly Ser 
545                 550                 555                 560 


Thr Tyr Ser Ala Ala Ile Thr Ala Glu Gly Glu Leu Tyr Thr Trp Gly 
                565                 570                 575     


Arg Gly Asn Tyr Gly Arg Leu Gly His Gly Ser Ser Glu Asp Glu Ala 
            580                 585                 590         


Ile Pro Met Leu Val Ala Gly Leu Lys Gly Leu Lys Val Ile Asp Val 
        595                 600                 605             


Ala Cys Gly Ser Gly Asp Ala Gln Thr Leu Ala Val Thr Glu Asn Gly 
    610                 615                 620                 


Gln Val Trp Ser Trp Gly Asp Gly Asp Tyr Gly Lys Leu Gly Arg Gly 
625                 630                 635                 640 


Gly Ser Asp Gly Cys Lys Thr Pro Lys Leu Ile Glu Lys Leu Gln Asp 
                645                 650                 655     


Leu Asp Val Val Lys Val Arg Cys Gly Ser Gln Phe Ser Ile Ala Leu 
            660                 665                 670         


Thr Lys Asp Gly Gln Val Tyr Ser Trp Gly Lys Gly Asp Asn Gln Arg 
        675                 680                 685             


Leu Gly His Gly Thr Glu Glu His Val Arg Tyr Pro Lys Leu Leu Glu 
    690                 695                 700                 


Gly Leu Gln Gly Lys Lys Val Ile Asp Val Ala Ala Gly Ser Thr His 
705                 710                 715                 720 


Cys Leu Ala Leu Thr Glu Asp Ser Glu Val His Ser Trp Gly Ser Asn 
                725                 730                 735     


Asp Gln Cys Gln His Phe Asp Thr Leu Arg Val Thr Lys Pro Glu Pro 
            740                 745                 750         


Ala Ala Leu Pro Gly Leu Asp Thr Lys His Ile Val Gly Ile Ala Cys 
        755                 760                 765             


Gly Pro Ala Gln Ser Phe Ala Trp Ser Ser Cys Ser Glu Trp Ser Ile 
    770                 775                 780                 


Gly Leu Arg Val Pro Phe Val Val Asp Ile Cys Ser Met Thr Phe Glu 
785                 790                 795                 800 


Gln Leu Asp Leu Leu Leu Arg Gln Val Ser Glu Gly Met Asp Gly Ser 
                805                 810                 815     


Ala Asp Trp Pro Pro Pro Gln Glu Lys Glu Cys Val Ala Val Ala Thr 
            820                 825                 830         


Leu Asn Leu Leu Arg Leu Gln Leu His Ala Ala Ile Ser His Gln Val 
        835                 840                 845             


Asp Pro Glu Phe Leu Gly Leu Gly Leu Gly Ser Ile Leu Leu Asn Ser 
    850                 855                 860                 


Leu Lys Gln Thr Val Val Thr Leu Ala Ser Ser Ala Gly Val Leu Ser 
865                 870                 875                 880 


Thr Val Gln Ser Ala Ala Gln Ala Val Leu Gln Ser Gly Trp Ser Val 
                885                 890                 895     


Leu Leu Pro Thr Ala Glu Glu Arg Ala Arg Ala Leu Ser Ala Leu Leu 
            900                 905                 910         


Pro Cys Ala Val Ser Gly Asn Glu Val Asn Ile Ser Pro Gly Arg Arg 
        915                 920                 925             


Phe Met Ile Asp Leu Leu Val Gly Ser Leu Met Ala Asp Gly Gly Leu 
    930                 935                 940                 


Glu Ser Ala Leu His Ala Ala Ile Thr Ala Glu Ile Gln Asp Ile Glu 
945                 950                 955                 960 


Ala Lys Lys Glu Ala Gln Lys Glu Lys Glu Ile Asp Glu Gln Glu Ala 
                965                 970                 975     


Asn Ala Ser Thr Phe His Arg Ser Arg Thr Pro Leu Asp Lys Asp Leu 
            980                 985                 990         


Ile Asn Thr Gly Ile Cys Glu Ser  Ser Gly Lys Gln Cys  Leu Pro Leu 
        995                 1000                 1005             


Val Gln  Leu Ile Gln Gln Leu  Leu Arg Asn Ile Ala  Ser Gln Thr 
    1010                 1015                 1020             


Val Ala  Arg Leu Lys Asp Val  Ala Arg Arg Ile Ser  Ser Cys Leu 
    1025                 1030                 1035             


Asp Phe  Glu Gln His Ser Arg  Glu Arg Ser Ala Ser  Leu Asp Leu 
    1040                 1045                 1050             


Leu Leu  Arg Phe Gln Arg Leu  Leu Ile Ser Lys Leu  Tyr Pro Gly 
    1055                 1060                 1065             


Glu Ser  Ile Gly Gln Thr Ser  Asp Ile Ser Ser Pro  Glu Leu Met 
    1070                 1075                 1080             


Gly Val  Gly Ser Leu Leu Lys  Lys Tyr Thr Ala Leu  Leu Cys Thr 
    1085                 1090                 1095             


His Ile  Gly Asp Ile Leu Pro  Val Ala Ala Ser Ile  Ala Ser Thr 
    1100                 1105                 1110             


Ser Trp  Arg His Phe Ala Glu  Val Ala Tyr Ile Val  Glu Gly Asp 
    1115                 1120                 1125             


Phe Thr  Gly Val Leu Leu Pro  Glu Leu Val Val Ser  Ile Val Leu 
    1130                 1135                 1140             


Leu Leu  Ser Lys Asn Ala Gly  Leu Met Gln Glu Ala  Gly Ala Val 
    1145                 1150                 1155             


Pro Leu  Leu Gly Gly Leu Leu  Glu His Leu Asp Arg  Phe Asn His 
    1160                 1165                 1170             


Leu Ala  Pro Gly Lys Glu Arg  Asp Asp His Glu Glu  Leu Ala Trp 
    1175                 1180                 1185             


Pro Gly  Ile Met Glu Ser Phe  Phe Thr Gly Gln Asn  Cys Arg Asn 
    1190                 1195                 1200             


Asn Glu  Glu Val Thr Leu Ile  Arg Lys Ala Asp Leu  Glu Asn His 
    1205                 1210                 1215             


Asn Lys  Asp Gly Gly Phe Trp  Thr Val Ile Asp Gly  Lys Val Tyr 
    1220                 1225                 1230             


Asp Ile  Lys Asp Phe Gln Thr  Gln Ser Leu Thr Gly  Asn Ser Ile 
    1235                 1240                 1245             


Leu Ala  Gln Phe Ala Gly Glu  Asp Pro Val Val Ala  Leu Glu Ala 
    1250                 1255                 1260             


Ala Leu  Gln Phe Glu Asp Thr  Arg Glu Ser Met His  Ala Phe Cys 
    1265                 1270                 1275             


Val Gly  Gln Tyr Leu Glu Pro  Asp Gln Glu Ile Val  Thr Ile Pro 
    1280                 1285                 1290             


Asp Leu  Gly Ser Leu Ser Ser  Pro Leu Ile Asp Thr  Glu Arg Asn 
    1295                 1300                 1305             


Leu Gly  Leu Leu Leu Gly Leu  His Ala Ser Tyr Leu  Ala Met Ser 
    1310                 1315                 1320             


Thr Pro  Leu Ser Pro Val Glu  Ile Glu Cys Ala Lys  Trp Leu Gln 
    1325                 1330                 1335             


Ser Ser  Ile Phe Ser Gly Gly  Leu Gln Thr Ser Gln  Ile His Tyr 
    1340                 1345                 1350             


Ser Tyr  Asn Glu Glu Lys Asp  Glu Asp His Cys Ser  Ser Pro Gly 
    1355                 1360                 1365             


Gly Thr  Pro Ala Ser Lys Ser  Arg Leu Cys Ser His  Arg Arg Ala 
    1370                 1375                 1380             


Leu Gly  Asp His Ser Gln Ala  Phe Leu Gln Ala Ile  Ala Asp Asn 
    1385                 1390                 1395             


Asn Ile  Gln Asp His Asn Val  Lys Asp Phe Leu Cys  Gln Ile Glu 
    1400                 1405                 1410             


Arg Tyr  Cys Arg Gln Cys His  Leu Thr Thr Pro Ile  Met Phe Pro 
    1415                 1420                 1425             


Pro Glu  His Pro Val Glu Glu  Val Gly Arg Leu Leu  Leu Cys Cys 
    1430                 1435                 1440             


Leu Leu  Lys His Glu Asp Leu  Gly His Val Ala Leu  Ser Leu Val 
    1445                 1450                 1455             


His Ala  Gly Ala Leu Gly Ile  Glu Gln Val Lys His  Arg Thr Leu 
    1460                 1465                 1470             


Pro Lys  Ser Val Val Asp Val  Cys Arg Val Val Tyr  Gln Ala Lys 
    1475                 1480                 1485             


Cys Ser  Leu Ile Lys Thr His  Gln Glu Gln Gly Arg  Ser Tyr Lys 
    1490                 1495                 1500             


Glu Val  Cys Ala Pro Val Ile  Glu Arg Leu Arg Phe  Leu Phe Asn 
    1505                 1510                 1515             


Glu Leu  Arg Pro Ala Val Cys  Asn Asp Leu Ser Ile  Met Ser Lys 
    1520                 1525                 1530             


Phe Lys  Leu Leu Ser Ser Leu  Pro Arg Trp Arg Arg  Ile Ala Gln 
    1535                 1540                 1545             


Lys Ile  Ile Arg Glu Arg Arg  Lys Lys Arg Val Pro  Lys Lys Pro 
    1550                 1555                 1560             


Glu Ser  Thr Asp Asp Glu Glu  Lys Ile Gly Asn Glu  Glu Ser Asp 
    1565                 1570                 1575             


Leu Glu  Glu Ala Cys Ile Leu  Pro His Ser Pro Ile  Asn Val Asp 
    1580                 1585                 1590             


Lys Arg  Pro Ile Ala Ile Lys  Ser Pro Lys Asp Lys  Trp Gln Pro 
    1595                 1600                 1605             


Leu Leu  Ser Thr Val Thr Gly  Val His Lys Tyr Lys  Trp Leu Lys 
    1610                 1615                 1620             


Gln Asn  Val Gln Gly Leu Tyr  Pro Gln Ser Pro Leu  Leu Ser Thr 
    1625                 1630                 1635             


Ile Ala  Glu Phe Ala Leu Lys  Glu Glu Pro Val Asp  Val Glu Lys 
    1640                 1645                 1650             


Met Arg  Lys Cys Leu Leu Lys  Gln Leu Glu Arg Ala  Glu Val Arg 
    1655                 1660                 1665             


Leu Glu  Gly Ile Asp Thr Ile  Leu Lys Leu Ala Ser  Lys Asn Phe 
    1670                 1675                 1680             


Leu Leu  Pro Ser Val Gln Tyr  Ala Met Phe Cys Gly  Trp Gln Arg 
    1685                 1690                 1695             


Leu Ile  Pro Glu Gly Ile Asp  Ile Gly Glu Pro Leu  Thr Asp Cys 
    1700                 1705                 1710             


Leu Lys  Asp Val Asp Leu Ile  Pro Pro Phe Asn Arg  Met Leu Leu 
    1715                 1720                 1725             


Glu Val  Thr Phe Gly Lys Leu  Tyr Ala Trp Ala Val  Gln Asn Ile 
    1730                 1735                 1740             


Arg Asn  Val Leu Met Asp Ala  Ser Ala Lys Phe Lys  Glu Leu Gly 
    1745                 1750                 1755             


Ile Gln  Pro Val Pro Leu Gln  Thr Ile Thr Asn Glu  Asn Pro Ser 
    1760                 1765                 1770             


Gly Pro  Ser Leu Gly Thr Ile  Pro Gln Ala Arg Phe  Leu Leu Val 
    1775                 1780                 1785             


Met Leu  Ser Met Leu Thr Leu  Gln His Gly Ala Asn  Asn Leu Asp 
    1790                 1795                 1800             


Leu Leu  Leu Asn Ser Gly Met  Leu Ala Leu Thr Gln  Thr Ala Leu 
    1805                 1810                 1815             


Arg Leu  Ile Gly Pro Ser Cys  Asp Asn Val Glu Glu  Asp Met Asn 
    1820                 1825                 1830             


Ala Ser  Ala Gln Gly Ala Ser  Ala Thr Val Leu Glu  Glu Thr Arg 
    1835                 1840                 1845             


Lys Glu  Thr Ala Pro Val Gln  Leu Pro Val Ser Gly  Pro Glu Leu 
    1850                 1855                 1860             


Ala Ala  Met Met Lys Ile Gly  Thr Arg Val Met Arg  Gly Val Asp 
    1865                 1870                 1875             


Trp Lys  Trp Gly Asp Gln Asp  Gly Pro Pro Pro Gly  Leu Gly Arg 
    1880                 1885                 1890             


Val Ile  Gly Glu Leu Gly Glu  Asp Gly Trp Ile Arg  Val Gln Trp 
    1895                 1900                 1905             


Asp Thr  Gly Ser Thr Asn Ser  Tyr Arg Met Gly Lys  Glu Gly Lys 
    1910                 1915                 1920             


Tyr Asp  Leu Lys Leu Ala Glu  Leu Pro Ala Ala Ala  Gln Pro Ser 
    1925                 1930                 1935             


Ala Glu  Asp Ser Asp Thr Glu  Asp Asp Ser Glu Ala  Glu Gln Thr 
    1940                 1945                 1950             


Glu Arg  Asn Ile His Pro Thr  Ala Met Met Phe Thr  Ser Thr Ile 
    1955                 1960                 1965             


Asn Leu  Leu Gln Thr Leu Cys  Leu Ser Ala Gly Val  His Ala Glu 
    1970                 1975                 1980             


Ile Met  Gln Ser Glu Ala Thr  Lys Thr Leu Cys Gly  Leu Leu Arg 
    1985                 1990                 1995             


Met Leu  Val Glu Ser Gly Thr  Thr Asp Lys Thr Ser  Ser Pro Asn 
    2000                 2005                 2010             


Arg Leu  Val Tyr Arg Glu Gln  His Arg Ser Trp Cys  Thr Leu Gly 
    2015                 2020                 2025             


Phe Val  Arg Ser Ile Ala Leu  Thr Pro Gln Val Cys  Gly Ala Leu 
    2030                 2035                 2040             


Ser Ser  Pro Gln Trp Ile Thr  Leu Leu Met Lys Val  Val Glu Gly 
    2045                 2050                 2055             


His Ala  Pro Phe Thr Ala Thr  Ser Leu Gln Arg Gln  Ile Leu Ala 
    2060                 2065                 2070             


Val His  Leu Leu Gln Ala Val  Leu Pro Ser Trp Asp  Lys Thr Glu 
    2075                 2080                 2085             


Arg Ala  Arg Asp Met Lys Cys  Leu Val Glu Lys Leu  Phe Asp Phe 
    2090                 2095                 2100             


Leu Gly  Ser Leu Leu Thr Thr  Cys Ser Ser Asp Val  Pro Leu Leu 
    2105                 2110                 2115             


Arg Glu  Ser Thr Leu Arg Arg  Arg Arg Val Arg Pro  Gln Ala Ser 
    2120                 2125                 2130             


Leu Thr  Ala Thr His Ser Ser  Thr Leu Ala Glu Glu  Val Val Ala 
    2135                 2140                 2145             


Leu Leu  Arg Thr Leu His Ser  Leu Thr Gln Trp Asn  Gly Leu Ile 
    2150                 2155                 2160             


Asn Lys  Tyr Ile Asn Ser Gln  Leu Arg Ser Ile Thr  His Ser Phe 
    2165                 2170                 2175             


Val Gly  Arg Pro Ser Glu Gly  Ala Gln Leu Glu Asp  Tyr Phe Pro 
    2180                 2185                 2190             


Asp Ser  Glu Asn Pro Glu Val  Gly Gly Leu Met Ala  Val Leu Ala 
    2195                 2200                 2205             


Val Ile  Gly Gly Ile Asp Gly  Arg Leu Arg Leu Gly  Gly Gln Val 
    2210                 2215                 2220             


Met His  Asp Glu Phe Gly Glu  Gly Thr Val Thr Arg  Ile Thr Pro 
    2225                 2230                 2235             


Lys Gly  Lys Ile Thr Val Gln  Phe Ser Asp Met Arg  Thr Cys Arg 
    2240                 2245                 2250             


Val Cys  Pro Leu Asn Gln Leu  Lys Pro Leu Pro Ala  Val Ala Phe 
    2255                 2260                 2265             


Asn Val  Asn Asn Leu Pro Phe  Thr Glu Pro Met Leu  Ser Val Trp 
    2270                 2275                 2280             


Ala Gln  Leu Val Asn Leu Ala  Gly Ser Lys Leu Glu  Lys His Lys 
    2285                 2290                 2295             


Ile Lys  Lys Ser Thr Lys Gln  Ala Phe Ala Gly Gln  Val Asp Leu 
    2300                 2305                 2310             


Asp Leu  Leu Arg Cys Gln Gln  Leu Lys Leu Tyr Ile  Leu Lys Ala 
    2315                 2320                 2325             


Gly Arg  Ala Leu Leu Ser His  Gln Asp Lys Leu Arg  Gln Ile Leu 
    2330                 2335                 2340             


Ser Gln  Pro Ala Val Gln Glu  Thr Gly Thr Val His  Thr Asp Asp 
    2345                 2350                 2355             


Gly Ala  Val Val Ser Pro Asp  Leu Gly Asp Met Ser  Pro Glu Gly 
    2360                 2365                 2370             


Pro Gln  Pro Pro Met Ile Leu  Leu Gln Gln Leu Leu  Ala Ser Ala 
    2375                 2380                 2385             


Thr Gln  Pro Ser Pro Val Lys  Ala Ile Phe Asp Lys  Gln Glu Leu 
    2390                 2395                 2400             


Glu Ala  Ala Ala Leu Ala Val  Cys Gln Cys Leu Ala  Val Glu Ser 
    2405                 2410                 2415             


Thr His  Pro Ser Ser Pro Gly  Phe Glu Asp Cys Ser  Ser Ser Glu 
    2420                 2425                 2430             


Ala Thr  Thr Pro Val Ala Val  Gln His Ile Arg Pro  Ala Arg Val 
    2435                 2440                 2445             


Lys Arg  Arg Lys Gln Ser Pro  Val Pro Ala Leu Pro  Ile Val Val 
    2450                 2455                 2460             


Gln Leu  Met Glu Met Gly Phe  Ser Arg Arg Asn Ile  Glu Phe Ala 
    2465                 2470                 2475             


Leu Lys  Ser Leu Thr Gly Ala  Ser Gly Asn Ala Ser  Ser Leu Pro 
    2480                 2485                 2490             


Gly Val  Glu Ala Leu Val Gly  Trp Leu Leu Asp His  Ser Asp Ile 
    2495                 2500                 2505             


Gln Val  Thr Glu Leu Ser Asp  Ala Asp Thr Val Ser  Asp Glu Tyr 
    2510                 2515                 2520             


Ser Asp  Glu Glu Val Val Glu  Asp Val Asp Asp Ala  Ala Tyr Ser 
    2525                 2530                 2535             


Met Ser  Thr Gly Ala Val Val  Thr Glu Ser Gln Thr  Tyr Lys Lys 
    2540                 2545                 2550             


Arg Ala  Asp Phe Leu Ser Asn  Asp Asp Tyr Ala Val  Tyr Val Arg 
    2555                 2560                 2565             


Glu Asn  Ile Gln Val Gly Met  Met Val Arg Cys Cys  Arg Ala Tyr 
    2570                 2575                 2580             


Glu Glu  Val Cys Glu Gly Asp  Val Gly Lys Val Ile  Lys Leu Asp 
    2585                 2590                 2595             


Arg Asp  Gly Leu His Asp Leu  Asn Val Gln Cys Asp  Trp Gln Gln 
    2600                 2605                 2610             


Lys Gly  Gly Thr Tyr Trp Val  Arg Tyr Ile His Val  Glu Leu Ile 
    2615                 2620                 2625             


Gly Tyr  Pro Pro Pro Ser Ser  Ser Ser His Ile Lys  Ile Gly Asp 
    2630                 2635                 2640             


Lys Val  Arg Val Lys Ala Ser  Val Thr Thr Pro Lys  Tyr Lys Trp 
    2645                 2650                 2655             


Gly Ser  Val Thr His Gln Ser  Val Gly Val Val Lys  Ala Phe Ser 
    2660                 2665                 2670             


Ala Asn  Gly Lys Asp Ile Ile  Val Asp Phe Pro Gln  Gln Ser His 
    2675                 2680                 2685             


Trp Thr  Gly Leu Leu Ser Glu  Met Glu Leu Val Pro  Ser Ile His 
    2690                 2695                 2700             


Pro Gly  Val Thr Cys Asp Gly  Cys Gln Met Phe Pro  Ile Asn Gly 
    2705                 2710                 2715             


Ser Arg  Phe Lys Cys Arg Asn  Cys Asp Asp Phe Asp  Phe Cys Glu 
    2720                 2725                 2730             


Thr Cys  Phe Lys Thr Lys Lys  His Asn Thr Arg His  Thr Phe Gly 
    2735                 2740                 2745             


Arg Ile  Asn Glu Pro Gly Gln  Ser Ala Val Phe Cys  Gly Arg Ser 
    2750                 2755                 2760             


Gly Lys  Gln Leu Lys Arg Cys  His Ser Ser Gln Pro  Gly Met Leu 
    2765                 2770                 2775             


Leu Asp  Ser Trp Ser Arg Met  Val Lys Ser Leu Asn  Val Ser Ser 
    2780                 2785                 2790             


Ser Val  Asn Gln Ala Ser Arg  Leu Ile Asp Gly Ser  Glu Pro Cys 
    2795                 2800                 2805             


Trp Gln  Ser Ser Gly Ser Gln  Gly Lys His Trp Ile  Arg Leu Glu 
    2810                 2815                 2820             


Ile Phe  Pro Asp Val Leu Val  His Arg Leu Lys Met  Ile Val Asp 
    2825                 2830                 2835             


Pro Ala  Asp Ser Ser Tyr Met  Pro Ser Leu Val Val  Val Ser Gly 
    2840                 2845                 2850             


Gly Asn  Ser Leu Asn Asn Leu  Ile Glu Leu Lys Thr  Ile Asn Ile 
    2855                 2860                 2865             


Asn Pro  Ser Asp Thr Thr Val  Pro Leu Leu Asn Asp  Cys Thr Glu 
    2870                 2875                 2880             


Tyr His  Arg Tyr Ile Glu Ile  Ala Ile Lys Gln Cys  Arg Ser Ser 
    2885                 2890                 2895             


Gly Ile  Asp Cys Lys Ile His  Gly Leu Ile Leu Leu  Gly Arg Ile 
    2900                 2905                 2910             


Arg Ala  Glu Glu Glu Asp Leu  Ala Ala Val Pro Phe  Leu Ala Ser 
    2915                 2920                 2925             


Asp Asn  Glu Glu Glu Glu Asp  Glu Lys Gly Asn Ser  Gly Ser Leu 
    2930                 2935                 2940             


Ile Arg  Lys Lys Ala Ala Gly  Leu Glu Ser Ala Ala  Thr Ile Arg 
    2945                 2950                 2955             


Thr Lys  Val Phe Val Trp Gly  Leu Asn Asp Lys Asp  Gln Leu Gly 
    2960                 2965                 2970             


Gly Leu  Lys Gly Ser Lys Ile  Lys Val Pro Ser Phe  Ser Glu Thr 
    2975                 2980                 2985             


Leu Ser  Ala Leu Asn Val Val  Gln Val Ala Gly Gly  Ser Lys Ser 
    2990                 2995                 3000             


Leu Phe  Ala Val Thr Val Glu  Gly Lys Val Tyr Ala  Cys Gly Glu 
    3005                 3010                 3015             


Ala Thr  Asn Gly Arg Leu Gly  Leu Gly Ile Ser Ser  Gly Thr Val 
    3020                 3025                 3030             


Pro Ile  Pro Arg Gln Ile Thr  Ala Leu Ser Ser Tyr  Val Val Lys 
    3035                 3040                 3045             


Lys Val  Ala Val His Ser Gly  Gly Arg His Ala Thr  Ala Leu Thr 
    3050                 3055                 3060             


Val Asp  Gly Lys Val Phe Ser  Trp Gly Glu Gly Asp  Asp Gly Lys 
    3065                 3070                 3075             


Leu Gly  His Phe Ser Arg Met  Asn Cys Asp Lys Pro  Arg Leu Ile 
    3080                 3085                 3090             


Glu Ala  Leu Lys Thr Lys Arg  Ile Arg Asp Ile Ala  Cys Gly Ser 
    3095                 3100                 3105             


Ser His  Ser Ala Ala Leu Thr  Ser Ser Gly Glu Leu  Tyr Thr Trp 
    3110                 3115                 3120             


Gly Leu  Gly Glu Tyr Gly Arg  Leu Gly His Gly Asp  Asn Thr Thr 
    3125                 3130                 3135             


Gln Leu  Lys Pro Lys Met Val  Lys Val Leu Leu Gly  His Arg Val 
    3140                 3145                 3150             


Ile Gln  Val Ala Cys Gly Ser  Arg Asp Ala Gln Thr  Leu Ala Leu 
    3155                 3160                 3165             


Thr Asp  Glu Gly Leu Val Phe  Ser Trp Gly Asp Gly  Asp Phe Gly 
    3170                 3175                 3180             


Lys Leu  Gly Arg Gly Gly Ser  Glu Gly Cys Asn Ile  Pro Gln Asn 
    3185                 3190                 3195             


Ile Glu  Arg Leu Asn Gly Gln  Gly Val Cys Gln Ile  Glu Cys Gly 
    3200                 3205                 3210             


Ala Gln  Phe Ser Leu Ala Leu  Thr Lys Ser Gly Val  Val Trp Thr 
    3215                 3220                 3225             


Trp Gly  Lys Gly Asp Tyr Phe  Arg Leu Gly His Gly  Ser Asp Val 
    3230                 3235                 3240             


His Val  Arg Lys Pro Gln Val  Val Glu Gly Leu Arg  Gly Lys Lys 
    3245                 3250                 3255             


Ile Val  His Val Ala Val Gly  Ala Leu His Cys Leu  Ala Val Thr 
    3260                 3265                 3270             


Asp Ser  Gly Gln Val Tyr Ala  Trp Gly Asp Asn Asp  His Gly Gln 
    3275                 3280                 3285             


Gln Gly  Asn Gly Thr Thr Thr  Val Asn Arg Lys Pro  Thr Leu Val 
    3290                 3295                 3300             


Gln Gly  Leu Glu Gly Gln Lys  Ile Thr Arg Val Ala  Cys Gly Ser 
    3305                 3310                 3315             


Ser His  Ser Val Ala Trp Thr  Thr Val Asp Val Ala  Thr Pro Ser 
    3320                 3325                 3330             


Val His  Glu Pro Val Leu Phe  Gln Thr Ala Arg Asp  Pro Leu Gly 
    3335                 3340                 3345             


Ala Ser  Tyr Leu Gly Val Pro  Ser Asp Ala Asp Ser  Ser Ala Ala 
    3350                 3355                 3360             


Ser Asn  Lys Ile Ser Gly Ala  Ser Asn Ser Lys Pro  Asn Arg Pro 
    3365                 3370                 3375             


Ser Leu  Ala Lys Ile Leu Leu  Ser Leu Asp Gly Asn  Leu Ala Lys 
    3380                 3385                 3390             


Gln Gln  Ala Leu Ser His Ile  Leu Thr Ala Leu Gln  Ile Met Tyr 
    3395                 3400                 3405             


Ala Arg  Asp Ala Val Val Gly  Ala Leu Met Pro Ala  Ala Met Ile 
    3410                 3415                 3420             


Ala Pro  Val Glu Cys Pro Ser  Phe Ser Ser Ala Ala  Pro Ser Asp 
    3425                 3430                 3435             


Ala Ser  Ala Met Ala Ser Pro  Met Asn Gly Glu Glu  Cys Met Leu 
    3440                 3445                 3450             


Ala Val  Asp Ile Glu Asp Arg  Leu Ser Pro Asn Pro  Trp Gln Glu 
    3455                 3460                 3465             


Lys Arg  Glu Ile Val Ser Ser  Glu Asp Ala Val Thr  Pro Ser Ala 
    3470                 3475                 3480             


Val Thr  Pro Ser Ala Pro Ser  Ala Ser Ala Arg Pro  Phe Ile Pro 
    3485                 3490                 3495             


Val Thr  Asp Asp Leu Gly Ala  Ala Ser Ile Ile Ala  Glu Thr Met 
    3500                 3505                 3510             


Thr Lys  Thr Lys Glu Asp Val  Glu Ser Gln Asn Lys  Ala Ala Gly 
    3515                 3520                 3525             


Pro Glu  Pro Gln Ala Leu Asp  Glu Phe Thr Ser Leu  Leu Ile Ala 
    3530                 3535                 3540             


Asp Asp  Thr Arg Val Val Val  Asp Leu Leu Lys Leu  Ser Val Cys 
    3545                 3550                 3555             


Ser Arg  Ala Gly Asp Arg Gly  Arg Asp Val Leu Ser  Ala Val Leu 
    3560                 3565                 3570             


Ser Gly  Met Gly Thr Ala Tyr  Pro Gln Val Ala Asp  Met Leu Leu 
    3575                 3580                 3585             


Glu Leu  Cys Val Thr Glu Leu  Glu Asp Val Ala Thr  Asp Ser Gln 
    3590                 3595                 3600             


Ser Gly  Arg Leu Ser Ser Gln  Pro Val Val Val Glu  Ser Ser His 
    3605                 3610                 3615             


Pro Tyr  Thr Asp Asp Thr Ser  Thr Ser Gly Thr Val  Lys Ile Pro 
    3620                 3625                 3630             


Gly Ala  Glu Gly Leu Arg Val  Glu Phe Asp Arg Gln  Cys Ser Thr 
    3635                 3640                 3645             


Glu Arg  Arg His Asp Pro Leu  Thr Val Met Asp Gly  Val Asn Arg 
    3650                 3655                 3660             


Ile Val  Ser Val Arg Ser Gly  Arg Glu Trp Ser Asp  Trp Ser Ser 
    3665                 3670                 3675             


Glu Leu  Arg Ile Pro Gly Asp  Glu Leu Lys Trp Lys  Phe Ile Ser 
    3680                 3685                 3690             


Asp Gly  Ser Val Asn Gly Trp  Gly Trp Arg Phe Thr  Val Tyr Pro 
    3695                 3700                 3705             


Ile Met  Pro Ala Ala Gly Pro  Lys Glu Leu Leu Ser  Asp Arg Cys 
    3710                 3715                 3720             


Val Leu  Ser Cys Pro Ser Met  Asp Leu Val Thr Cys  Leu Leu Asp 
    3725                 3730                 3735             


Phe Arg  Leu Asn Leu Ala Ser  Asn Arg Ser Ile Val  Pro Arg Leu 
    3740                 3745                 3750             


Ala Ala  Ser Leu Ala Ala Cys  Ala Gln Leu Ser Ala  Leu Ala Ala 
    3755                 3760                 3765             


Ser His  Arg Met Trp Ala Leu  Gln Arg Leu Arg Lys  Leu Leu Thr 
    3770                 3775                 3780             


Thr Glu  Phe Gly Gln Ser Ile  Asn Ile Asn Arg Leu  Leu Gly Glu 
    3785                 3790                 3795             


Asn Asp  Gly Glu Thr Arg Ala  Leu Ser Phe Thr Gly  Ser Ala Leu 
    3800                 3805                 3810             


Ala Ala  Leu Val Lys Gly Leu  Pro Glu Ala Leu Gln  Arg Gln Phe 
    3815                 3820                 3825             


Glu Tyr  Glu Asp Pro Ile Val  Arg Gly Gly Lys Gln  Leu Leu His 
    3830                 3835                 3840             


Ser Pro  Phe Phe Lys Val Leu  Val Ala Leu Ala Cys  Asp Leu Glu 
    3845                 3850                 3855             


Leu Asp  Thr Leu Pro Cys Cys  Ala Glu Thr His Lys  Trp Ala Trp 
    3860                 3865                 3870             


Phe Arg  Arg Tyr Cys Met Ala  Ser Arg Val Ala Val  Ala Leu Asp 
    3875                 3880                 3885             


Lys Arg  Thr Pro Leu Pro Arg  Leu Phe Leu Asp Glu  Val Ala Lys 
    3890                 3895                 3900             


Lys Ile  Arg Glu Leu Met Ala  Asp Ser Glu Asn Met  Asp Val Leu 
    3905                 3910                 3915             


His Glu  Ser His Asp Ile Phe  Lys Arg Glu Gln Asp  Glu Gln Leu 
    3920                 3925                 3930             


Val Gln  Trp Met Asn Arg Arg  Pro Asp Asp Trp Thr  Leu Ser Ala 
    3935                 3940                 3945             


Gly Gly  Ser Gly Thr Ile Tyr  Gly Trp Gly His Asn  His Arg Gly 
    3950                 3955                 3960             


Gln Leu  Gly Gly Ile Glu Gly  Ala Lys Val Lys Val  Pro Thr Pro 
    3965                 3970                 3975             


Cys Glu  Ala Leu Ala Thr Leu  Arg Pro Val Gln Leu  Ile Gly Gly 
    3980                 3985                 3990             


Glu Gln  Thr Leu Phe Ala Val  Thr Ala Asp Gly Lys  Leu Tyr Ala 
    3995                 4000                 4005             


Thr Gly  Tyr Gly Ala Gly Gly  Arg Leu Gly Ile Gly  Gly Thr Glu 
    4010                 4015                 4020             


Ser Val  Ser Thr Pro Thr Leu  Leu Glu Ser Ile Gln  His Val Phe 
    4025                 4030                 4035             


Ile Lys  Lys Val Ala Val Asn  Ser Gly Gly Lys His  Cys Leu Ala 
    4040                 4045                 4050             


Leu Ser  Ser Glu Gly Glu Val  Tyr Ser Trp Gly Glu  Ala Glu Asp 
    4055                 4060                 4065             


Gly Lys  Leu Gly His Gly Asn  Arg Ser Pro Cys Asp  Arg Pro Arg 
    4070                 4075                 4080             


Val Ile  Glu Ser Leu Arg Gly  Ile Glu Val Val Asp  Val Ala Ala 
    4085                 4090                 4095             


Gly Gly  Ala His Ser Ala Cys  Val Thr Ala Ala Gly  Asp Leu Tyr 
    4100                 4105                 4110             


Thr Trp  Gly Lys Gly Arg Tyr  Gly Arg Leu Gly His  Ser Asp Ser 
    4115                 4120                 4125             


Glu Asp  Gln Leu Lys Pro Lys  Leu Val Glu Ala Leu  Gln Gly His 
    4130                 4135                 4140             


Arg Val  Val Asp Ile Ala Cys  Gly Ser Gly Asp Ala  Gln Thr Leu 
    4145                 4150                 4155             


Cys Leu  Thr Asp Asp Asp Thr  Val Trp Ser Trp Gly  Asp Gly Asp 
    4160                 4165                 4170             


Tyr Gly  Lys Leu Gly Arg Gly  Gly Ser Asp Gly Cys  Lys Val Pro 
    4175                 4180                 4185             


Met Lys  Ile Asp Ser Leu Thr  Gly Leu Gly Val Val  Lys Val Glu 
    4190                 4195                 4200             


Cys Gly  Ser Gln Phe Ser Val  Ala Leu Thr Lys Ser  Gly Ala Val 
    4205                 4210                 4215             


Tyr Thr  Trp Gly Lys Gly Asp  Tyr His Arg Leu Gly  His Gly Ser 
    4220                 4225                 4230             


Asp Asp  His Val Arg Arg Pro  Arg Gln Val Gln Gly  Leu Gln Gly 
    4235                 4240                 4245             


Lys Lys  Val Ile Ala Ile Ala  Thr Gly Ser Leu His  Cys Val Cys 
    4250                 4255                 4260             


Cys Thr  Glu Asp Gly Glu Val  Tyr Thr Trp Gly Asp  Asn Asp Glu 
    4265                 4270                 4275             


Gly Gln  Leu Gly Asp Gly Thr  Thr Asn Ala Ile Gln  Arg Pro Arg 
    4280                 4285                 4290             


Leu Val  Ala Ala Leu Gln Gly  Lys Lys Val Asn Arg  Val Ala Cys 
    4295                 4300                 4305             


Gly Ser  Ala His Thr Leu Ala  Trp Ser Thr Ser Lys  Pro Ala Ser 
    4310                 4315                 4320             


Ala Gly  Lys Leu Pro Ala Gln  Val Pro Met Glu Tyr  Asn His Leu 
    4325                 4330                 4335             


Gln Glu  Ile Pro Ile Ile Ala  Leu Arg Asn Arg Leu  Leu Leu Leu 
    4340                 4345                 4350             


His His  Leu Ser Glu Leu Phe  Cys Pro Cys Ile Pro  Met Phe Asp 
    4355                 4360                 4365             


Leu Glu  Gly Ser Leu Asp Glu  Thr Gly Leu Gly Pro  Ser Val Gly 
    4370                 4375                 4380             


Phe Asp  Thr Leu Arg Gly Ile  Leu Ile Ser Gln Gly  Lys Glu Ala 
    4385                 4390                 4395             


Ala Phe  Arg Lys Val Val Gln  Ala Thr Met Val Arg  Asp Arg Gln 
    4400                 4405                 4410             


His Gly  Pro Val Val Glu Leu  Asn Arg Ile Gln Val  Lys Arg Ser 
    4415                 4420                 4425             


Arg Ser  Lys Gly Gly Leu Ala  Gly Pro Asp Gly Thr  Lys Ser Val 
    4430                 4435                 4440             


Phe Gly  Gln Met Cys Ala Lys  Met Ser Ser Phe Gly  Pro Asp Ser 
    4445                 4450                 4455             


Leu Leu  Leu Pro His Arg Val  Trp Lys Val Lys Phe  Val Gly Glu 
    4460                 4465                 4470             


Ser Val  Asp Asp Cys Gly Gly  Gly Tyr Ser Glu Ser  Ile Ala Glu 
    4475                 4480                 4485             


Ile Cys  Glu Glu Leu Gln Asn  Gly Leu Thr Pro Leu  Leu Ile Val 
    4490                 4495                 4500             


Thr Pro  Asn Gly Arg Asp Glu  Ser Gly Ala Asn Arg  Asp Cys Tyr 
    4505                 4510                 4515             


Leu Leu  Ser Pro Ala Ala Arg  Ala Pro Val His Ser  Ser Met Phe 
    4520                 4525                 4530             


Arg Phe  Leu Gly Val Leu Leu  Gly Ile Ala Ile Arg  Thr Gly Ser 
    4535                 4540                 4545             


Pro Leu  Ser Leu Asn Leu Ala  Glu Pro Val Trp Lys  Gln Leu Ala 
    4550                 4555                 4560             


Gly Met  Ser Leu Thr Ile Ala  Asp Leu Ser Glu Val  Asp Lys Asp 
    4565                 4570                 4575             


Phe Ile  Pro Gly Leu Met Tyr  Ile Arg Asp Asn Glu  Ala Thr Ser 
    4580                 4585                 4590             


Glu Glu  Phe Glu Ala Met Ser  Leu Pro Phe Thr Val  Pro Ser Ala 
    4595                 4600                 4605             


Ser Gly  Gln Asp Ile Gln Leu  Ser Ser Lys His Thr  His Ile Thr 
    4610                 4615                 4620             


Leu Asp  Asn Arg Ala Glu Tyr  Val Arg Leu Ala Ile  Asn Tyr Arg 
    4625                 4630                 4635             


Leu His  Glu Phe Asp Glu Gln  Val Ala Ala Val Arg  Glu Gly Met 
    4640                 4645                 4650             


Ala Arg  Val Val Pro Val Pro  Leu Leu Ser Leu Phe  Thr Gly Tyr 
    4655                 4660                 4665             


Glu Leu  Glu Thr Met Val Cys  Gly Ser Pro Asp Ile  Pro Leu His 
    4670                 4675                 4680             


Leu Leu  Lys Ser Val Ala Thr  Tyr Lys Gly Ile Glu  Pro Ser Ala 
    4685                 4690                 4695             


Ser Leu  Ile Gln Trp Phe Trp  Glu Val Met Glu Ser  Phe Ser Asn 
    4700                 4705                 4710             


Thr Glu  Arg Ser Leu Phe Leu  Arg Phe Val Trp Gly  Arg Thr Arg 
    4715                 4720                 4725             


Leu Pro  Arg Thr Ile Ala Asp  Phe Arg Gly Arg Asp  Phe Val Ile 
    4730                 4735                 4740             


Gln Val  Leu Asp Lys Tyr Asn  Pro Pro Asp His Phe  Leu Pro Glu 
    4745                 4750                 4755             


Ser Tyr  Thr Cys Phe Phe Leu  Leu Lys Leu Pro Arg  Tyr Ser Cys 
    4760                 4765                 4770             


Lys Gln  Val Leu Glu Glu Lys  Leu Lys Tyr Ala Ile  His Phe Cys 
    4775                 4780                 4785             


Lys Ser  Ile Asp Thr Asp Asp  Tyr Ala Arg Ile Ala  Leu Thr Gly 
    4790                 4795                 4800             


Glu Pro  Ala Ala Asp Asp Ser  Ser Asp Asp Ser Asp  Asn Glu Asp 
    4805                 4810                 4815             


Val Asp  Ser Phe Ala Ser Asp  Ser Thr Gln Asp Tyr  Leu Thr Gly 
    4820                 4825                 4830             


His 
    


<210>  29
<211>  301
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9Y314
<309>  2016-09-07
<313>  (1)..(301)

<400>  29

Met Thr Arg His Gly Lys Asn Cys Thr Ala Gly Ala Val Tyr Thr Tyr 
1               5                   10                  15      


His Glu Lys Lys Lys Asp Thr Ala Ala Ser Gly Tyr Gly Thr Gln Asn 
            20                  25                  30          


Ile Arg Leu Ser Arg Asp Ala Val Lys Asp Phe Asp Cys Cys Cys Leu 
        35                  40                  45              


Ser Leu Gln Pro Cys His Asp Pro Val Val Thr Pro Asp Gly Tyr Leu 
    50                  55                  60                  


Tyr Glu Arg Glu Ala Ile Leu Glu Tyr Ile Leu His Gln Lys Lys Glu 
65                  70                  75                  80  


Ile Ala Arg Gln Met Lys Ala Tyr Glu Lys Gln Arg Gly Thr Arg Arg 
                85                  90                  95      


Glu Glu Gln Lys Glu Leu Gln Arg Ala Ala Ser Gln Asp His Val Arg 
            100                 105                 110         


Gly Phe Leu Glu Lys Glu Ser Ala Ile Val Ser Arg Pro Leu Asn Pro 
        115                 120                 125             


Phe Thr Ala Lys Ala Leu Ser Gly Thr Ser Pro Asp Asp Val Gln Pro 
    130                 135                 140                 


Gly Pro Ser Val Gly Pro Pro Ser Lys Asp Lys Asp Lys Val Leu Pro 
145                 150                 155                 160 


Ser Phe Trp Ile Pro Ser Leu Thr Pro Glu Ala Lys Ala Thr Lys Leu 
                165                 170                 175     


Glu Lys Pro Ser Arg Thr Val Thr Cys Pro Met Ser Gly Lys Pro Leu 
            180                 185                 190         


Arg Met Ser Asp Leu Thr Pro Val His Phe Thr Pro Leu Asp Ser Ser 
        195                 200                 205             


Val Asp Arg Val Gly Leu Ile Thr Arg Ser Glu Arg Tyr Val Cys Ala 
    210                 215                 220                 


Val Thr Arg Asp Ser Leu Ser Asn Ala Thr Pro Cys Ala Val Leu Arg 
225                 230                 235                 240 


Pro Ser Gly Ala Val Val Thr Leu Glu Cys Val Glu Lys Leu Ile Arg 
                245                 250                 255     


Lys Asp Met Val Asp Pro Val Thr Gly Asp Lys Leu Thr Asp Arg Asp 
            260                 265                 270         


Ile Ile Val Leu Gln Arg Gly Gly Thr Gly Phe Ala Gly Ser Gly Val 
        275                 280                 285             


Lys Leu Gln Ala Glu Lys Ser Arg Pro Val Met Gln Ala 
    290                 295                 300     


<210>  30
<211>  165
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P62937
<309>  2016-09-07
<313>  (1)..(165)

<400>  30

Met Val Asn Pro Thr Val Phe Phe Asp Ile Ala Val Asp Gly Glu Pro 
1               5                   10                  15      


Leu Gly Arg Val Ser Phe Glu Leu Phe Ala Asp Lys Val Pro Lys Thr 
            20                  25                  30          


Ala Glu Asn Phe Arg Ala Leu Ser Thr Gly Glu Lys Gly Phe Gly Tyr 
        35                  40                  45              


Lys Gly Ser Cys Phe His Arg Ile Ile Pro Gly Phe Met Cys Gln Gly 
    50                  55                  60                  


Gly Asp Phe Thr Arg His Asn Gly Thr Gly Gly Lys Ser Ile Tyr Gly 
65                  70                  75                  80  


Glu Lys Phe Glu Asp Glu Asn Phe Ile Leu Lys His Thr Gly Pro Gly 
                85                  90                  95      


Ile Leu Ser Met Ala Asn Ala Gly Pro Asn Thr Asn Gly Ser Gln Phe 
            100                 105                 110         


Phe Ile Cys Thr Ala Lys Thr Glu Trp Leu Asp Gly Lys His Val Val 
        115                 120                 125             


Phe Gly Lys Val Lys Glu Gly Met Asn Ile Val Glu Ala Met Glu Arg 
    130                 135                 140                 


Phe Gly Ser Arg Asn Gly Lys Thr Ser Lys Lys Ile Thr Ile Ala Asp 
145                 150                 155                 160 


Cys Gly Gln Leu Glu 
                165 


<210>  31
<211>  172
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q14011
<309>  2016-09-07
<313>  (1)..(172)

<400>  31

Met Ala Ser Asp Glu Gly Lys Leu Phe Val Gly Gly Leu Ser Phe Asp 
1               5                   10                  15      


Thr Asn Glu Gln Ser Leu Glu Gln Val Phe Ser Lys Tyr Gly Gln Ile 
            20                  25                  30          


Ser Glu Val Val Val Val Lys Asp Arg Glu Thr Gln Arg Ser Arg Gly 
        35                  40                  45              


Phe Gly Phe Val Thr Phe Glu Asn Ile Asp Asp Ala Lys Asp Ala Met 
    50                  55                  60                  


Met Ala Met Asn Gly Lys Ser Val Asp Gly Arg Gln Ile Arg Val Asp 
65                  70                  75                  80  


Gln Ala Gly Lys Ser Ser Asp Asn Arg Ser Arg Gly Tyr Arg Gly Gly 
                85                  90                  95      


Ser Ala Gly Gly Arg Gly Phe Phe Arg Gly Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Phe Ser Arg Gly Gly Gly Asp Arg Gly Tyr Gly Gly Asn Arg Phe 
        115                 120                 125             


Glu Ser Arg Ser Gly Gly Tyr Gly Gly Ser Arg Asp Tyr Tyr Ser Ser 
    130                 135                 140                 


Arg Ser Gln Ser Gly Gly Tyr Ser Asp Arg Ser Ser Gly Gly Ser Tyr 
145                 150                 155                 160 


Arg Asp Ser Tyr Asp Ser Tyr Ala Thr His Asn Glu 
                165                 170         


<210>  32
<211>  148
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P61626
<309>  2016-09-07
<313>  (1)..(148)

<400>  32

Met Lys Ala Leu Ile Val Leu Gly Leu Val Leu Leu Ser Val Thr Val 
1               5                   10                  15      


Gln Gly Lys Val Phe Glu Arg Cys Glu Leu Ala Arg Thr Leu Lys Arg 
            20                  25                  30          


Leu Gly Met Asp Gly Tyr Arg Gly Ile Ser Leu Ala Asn Trp Met Cys 
        35                  40                  45              


Leu Ala Lys Trp Glu Ser Gly Tyr Asn Thr Arg Ala Thr Asn Tyr Asn 
    50                  55                  60                  


Ala Gly Asp Arg Ser Thr Asp Tyr Gly Ile Phe Gln Ile Asn Ser Arg 
65                  70                  75                  80  


Tyr Trp Cys Asn Asp Gly Lys Thr Pro Gly Ala Val Asn Ala Cys His 
                85                  90                  95      


Leu Ser Cys Ser Ala Leu Leu Gln Asp Asn Ile Ala Asp Ala Val Ala 
            100                 105                 110         


Cys Ala Lys Arg Val Val Arg Asp Pro Gln Gly Ile Arg Ala Trp Val 
        115                 120                 125             


Ala Trp Arg Asn Arg Cys Gln Asn Arg Asp Val Arg Gln Tyr Val Gln 
    130                 135                 140                 


Gly Cys Gly Val 
145             


<210>  33
<211>  306
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q86U42
<309>  2016-09-07
<313>  (1)..(306)

<400>  33

Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala Gly Gly 
1               5                   10                  15      


Arg Gly Ser Gly Pro Gly Arg Arg Arg His Leu Val Pro Gly Ala Gly 
            20                  25                  30          


Gly Glu Ala Gly Glu Gly Ala Pro Gly Gly Ala Gly Asp Tyr Gly Asn 
        35                  40                  45              


Gly Leu Glu Ser Glu Glu Leu Glu Pro Glu Glu Leu Leu Leu Glu Pro 
    50                  55                  60                  


Glu Pro Glu Pro Glu Pro Glu Glu Glu Pro Pro Arg Pro Arg Ala Pro 
65                  70                  75                  80  


Pro Gly Ala Pro Gly Pro Gly Pro Gly Ser Gly Ala Pro Gly Ser Gln 
                85                  90                  95      


Glu Glu Glu Glu Glu Pro Gly Leu Val Glu Gly Asp Pro Gly Asp Gly 
            100                 105                 110         


Ala Ile Glu Asp Pro Glu Leu Glu Ala Ile Lys Ala Arg Val Arg Glu 
        115                 120                 125             


Met Glu Glu Glu Ala Glu Lys Leu Lys Glu Leu Gln Asn Glu Val Glu 
    130                 135                 140                 


Lys Gln Met Asn Met Ser Pro Pro Pro Gly Asn Ala Gly Pro Val Ile 
145                 150                 155                 160 


Met Ser Ile Glu Glu Lys Met Glu Ala Asp Ala Arg Ser Ile Tyr Val 
                165                 170                 175     


Gly Asn Val Asp Tyr Gly Ala Thr Ala Glu Glu Leu Glu Ala His Phe 
            180                 185                 190         


His Gly Cys Gly Ser Val Asn Arg Val Thr Ile Leu Cys Asp Lys Phe 
        195                 200                 205             


Ser Gly His Pro Lys Gly Phe Ala Tyr Ile Glu Phe Ser Asp Lys Glu 
    210                 215                 220                 


Ser Val Arg Thr Ser Leu Ala Leu Asp Glu Ser Leu Phe Arg Gly Arg 
225                 230                 235                 240 


Gln Ile Lys Val Ile Pro Lys Arg Thr Asn Arg Pro Gly Ile Ser Thr 
                245                 250                 255     


Thr Asp Arg Gly Phe Pro Arg Ala Arg Tyr Arg Ala Arg Thr Thr Asn 
            260                 265                 270         


Tyr Asn Ser Ser Arg Ser Arg Phe Tyr Ser Gly Phe Asn Ser Arg Pro 
        275                 280                 285             


Arg Gly Arg Val Tyr Arg Gly Arg Ala Arg Ala Thr Ser Trp Tyr Ser 
    290                 295                 300                 


Pro Tyr 
305     


<210>  34
<211>  372
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P09651
<309>  1993-04-24
<313>  (1)..(372)

<400>  34

Met Ser Lys Ser Glu Ser Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu 
1               5                   10                  15      


Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp Glu Ser Leu Arg Ser 
            20                  25                  30          


His Phe Glu Gln Trp Gly Thr Leu Thr Asp Cys Val Val Met Arg Asp 
        35                  40                  45              


Pro Asn Thr Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ala Thr 
    50                  55                  60                  


Val Glu Glu Val Asp Ala Ala Met Asn Ala Arg Pro His Lys Val Asp 
65                  70                  75                  80  


Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Gln 
                85                  90                  95      


Arg Pro Gly Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile 
            100                 105                 110         


Lys Glu Asp Thr Glu Glu His His Leu Arg Asp Tyr Phe Glu Gln Tyr 
        115                 120                 125             


Gly Lys Ile Glu Val Ile Glu Ile Met Thr Asp Arg Gly Ser Gly Lys 
    130                 135                 140                 


Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp His Asp Ser Val Asp 
145                 150                 155                 160 


Lys Ile Val Ile Gln Lys Tyr His Thr Val Asn Gly His Asn Cys Glu 
                165                 170                 175     


Val Arg Lys Ala Leu Ser Lys Gln Glu Met Ala Ser Ala Ser Ser Ser 
            180                 185                 190         


Gln Arg Gly Arg Ser Gly Ser Gly Asn Phe Gly Gly Gly Arg Gly Gly 
        195                 200                 205             


Gly Phe Gly Gly Asn Asp Asn Phe Gly Arg Gly Gly Asn Phe Ser Gly 
    210                 215                 220                 


Arg Gly Gly Phe Gly Gly Ser Arg Gly Gly Gly Gly Tyr Gly Gly Ser 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Phe Gly Asn Asp Gly Gly Tyr Gly Gly Gly 
                245                 250                 255     


Gly Pro Gly Tyr Ser Gly Gly Ser Arg Gly Tyr Gly Ser Gly Gly Gln 
            260                 265                 270         


Gly Tyr Gly Asn Gln Gly Ser Gly Tyr Gly Gly Ser Gly Ser Tyr Asp 
        275                 280                 285             


Ser Tyr Asn Asn Gly Gly Gly Gly Gly Phe Gly Gly Gly Ser Gly Ser 
    290                 295                 300                 


Asn Phe Gly Gly Gly Gly Ser Tyr Asn Asp Phe Gly Asn Tyr Asn Asn 
305                 310                 315                 320 


Gln Ser Ser Asn Phe Gly Pro Met Lys Gly Gly Asn Phe Gly Gly Arg 
                325                 330                 335     


Ser Ser Gly Pro Tyr Gly Gly Gly Gly Gln Tyr Phe Ala Lys Pro Arg 
            340                 345                 350         


Asn Gln Gly Gly Tyr Gly Gly Ser Ser Ser Ser Ser Ser Tyr Gly Ser 
        355                 360                 365             


Gly Arg Arg Phe 
    370         


<210>  35
<211>  251
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q92688
<309>  2016-09-07
<313>  (1)..(251)

<400>  35

Met Asp Met Lys Arg Arg Ile His Leu Glu Leu Arg Asn Arg Thr Pro 
1               5                   10                  15      


Ala Ala Val Arg Glu Leu Val Leu Asp Asn Cys Lys Ser Asn Asp Gly 
            20                  25                  30          


Lys Ile Glu Gly Leu Thr Ala Glu Phe Val Asn Leu Glu Phe Leu Ser 
        35                  40                  45              


Leu Ile Asn Val Gly Leu Ile Ser Val Ser Asn Leu Pro Lys Leu Pro 
    50                  55                  60                  


Lys Leu Lys Lys Leu Glu Leu Ser Glu Asn Arg Ile Phe Gly Gly Leu 
65                  70                  75                  80  


Asp Met Leu Ala Glu Lys Leu Pro Asn Leu Thr His Leu Asn Leu Ser 
                85                  90                  95      


Gly Asn Lys Leu Lys Asp Ile Ser Thr Leu Glu Pro Leu Lys Lys Leu 
            100                 105                 110         


Glu Cys Leu Lys Ser Leu Asp Leu Phe Asn Cys Glu Val Thr Asn Leu 
        115                 120                 125             


Asn Asp Tyr Arg Glu Ser Val Phe Lys Leu Leu Pro Gln Leu Thr Tyr 
    130                 135                 140                 


Leu Asp Gly Tyr Asp Arg Glu Asp Gln Glu Ala Pro Asp Ser Asp Ala 
145                 150                 155                 160 


Glu Val Asp Gly Val Asp Glu Glu Glu Glu Asp Glu Glu Gly Glu Asp 
                165                 170                 175     


Glu Glu Asp Glu Asp Asp Glu Asp Gly Glu Glu Glu Glu Phe Asp Glu 
            180                 185                 190         


Glu Asp Asp Glu Asp Glu Asp Val Glu Gly Asp Glu Asp Asp Asp Glu 
        195                 200                 205             


Val Ser Glu Glu Glu Glu Glu Phe Gly Leu Asp Glu Glu Asp Glu Asp 
    210                 215                 220                 


Glu Asp Glu Asp Glu Glu Glu Glu Glu Gly Gly Lys Gly Glu Lys Arg 
225                 230                 235                 240 


Lys Arg Glu Thr Asp Asp Glu Gly Glu Asp Asp 
                245                 250     


<210>  36
<211>  531
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P26599
<309>  1993-04-24
<313>  (1)..(531)

<400>  36

Met Asp Gly Ile Val Pro Asp Ile Ala Val Gly Thr Lys Arg Gly Ser 
1               5                   10                  15      


Asp Glu Leu Phe Ser Thr Cys Val Thr Asn Gly Pro Phe Ile Met Ser 
            20                  25                  30          


Ser Asn Ser Ala Ser Ala Ala Asn Gly Asn Asp Ser Lys Lys Phe Lys 
        35                  40                  45              


Gly Asp Ser Arg Ser Ala Gly Val Pro Ser Arg Val Ile His Ile Arg 
    50                  55                  60                  


Lys Leu Pro Ile Asp Val Thr Glu Gly Glu Val Ile Ser Leu Gly Leu 
65                  70                  75                  80  


Pro Phe Gly Lys Val Thr Asn Leu Leu Met Leu Lys Gly Lys Asn Gln 
                85                  90                  95      


Ala Phe Ile Glu Met Asn Thr Glu Glu Ala Ala Asn Thr Met Val Asn 
            100                 105                 110         


Tyr Tyr Thr Ser Val Thr Pro Val Leu Arg Gly Gln Pro Ile Tyr Ile 
        115                 120                 125             


Gln Phe Ser Asn His Lys Glu Leu Lys Thr Asp Ser Ser Pro Asn Gln 
    130                 135                 140                 


Ala Arg Ala Gln Ala Ala Leu Gln Ala Val Asn Ser Val Gln Ser Gly 
145                 150                 155                 160 


Asn Leu Ala Leu Ala Ala Ser Ala Ala Ala Val Asp Ala Gly Met Ala 
                165                 170                 175     


Met Ala Gly Gln Ser Pro Val Leu Arg Ile Ile Val Glu Asn Leu Phe 
            180                 185                 190         


Tyr Pro Val Thr Leu Asp Val Leu His Gln Ile Phe Ser Lys Phe Gly 
        195                 200                 205             


Thr Val Leu Lys Ile Ile Thr Phe Thr Lys Asn Asn Gln Phe Gln Ala 
    210                 215                 220                 


Leu Leu Gln Tyr Ala Asp Pro Val Ser Ala Gln His Ala Lys Leu Ser 
225                 230                 235                 240 


Leu Asp Gly Gln Asn Ile Tyr Asn Ala Cys Cys Thr Leu Arg Ile Asp 
                245                 250                 255     


Phe Ser Lys Leu Thr Ser Leu Asn Val Lys Tyr Asn Asn Asp Lys Ser 
            260                 265                 270         


Arg Asp Tyr Thr Arg Pro Asp Leu Pro Ser Gly Asp Ser Gln Pro Ser 
        275                 280                 285             


Leu Asp Gln Thr Met Ala Ala Ala Phe Gly Leu Ser Val Pro Asn Val 
    290                 295                 300                 


His Gly Ala Leu Ala Pro Leu Ala Ile Pro Ser Ala Ala Ala Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Gly Arg Ile Ala Ile Pro Gly Leu Ala Gly Ala Gly Asn 
                325                 330                 335     


Ser Val Leu Leu Val Ser Asn Leu Asn Pro Glu Arg Val Thr Pro Gln 
            340                 345                 350         


Ser Leu Phe Ile Leu Phe Gly Val Tyr Gly Asp Val Gln Arg Val Lys 
        355                 360                 365             


Ile Leu Phe Asn Lys Lys Glu Asn Ala Leu Val Gln Met Ala Asp Gly 
    370                 375                 380                 


Asn Gln Ala Gln Leu Ala Met Ser His Leu Asn Gly His Lys Leu His 
385                 390                 395                 400 


Gly Lys Pro Ile Arg Ile Thr Leu Ser Lys His Gln Asn Val Gln Leu 
                405                 410                 415     


Pro Arg Glu Gly Gln Glu Asp Gln Gly Leu Thr Lys Asp Tyr Gly Asn 
            420                 425                 430         


Ser Pro Leu His Arg Phe Lys Lys Pro Gly Ser Lys Asn Phe Gln Asn 
        435                 440                 445             


Ile Phe Pro Pro Ser Ala Thr Leu His Leu Ser Asn Ile Pro Pro Ser 
    450                 455                 460                 


Val Ser Glu Glu Asp Leu Lys Val Leu Phe Ser Ser Asn Gly Gly Val 
465                 470                 475                 480 


Val Lys Gly Phe Lys Phe Phe Gln Lys Asp Arg Lys Met Ala Leu Ile 
                485                 490                 495     


Gln Met Gly Ser Val Glu Glu Ala Val Gln Ala Leu Ile Asp Leu His 
            500                 505                 510         


Asn His Asp Leu Gly Glu Asn His His Leu Arg Val Ser Phe Ser Lys 
        515                 520                 525             


Ser Thr Ile 
    530     


<210>  37
<211>  160
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q15185
<309>  2016-09-07
<313>  (1)..(160)

<400>  37

Met Gln Pro Ala Ser Ala Lys Trp Tyr Asp Arg Arg Asp Tyr Val Phe 
1               5                   10                  15      


Ile Glu Phe Cys Val Glu Asp Ser Lys Asp Val Asn Val Asn Phe Glu 
            20                  25                  30          


Lys Ser Lys Leu Thr Phe Ser Cys Leu Gly Gly Ser Asp Asn Phe Lys 
        35                  40                  45              


His Leu Asn Glu Ile Asp Leu Phe His Cys Ile Asp Pro Asn Asp Ser 
    50                  55                  60                  


Lys His Lys Arg Thr Asp Arg Ser Ile Leu Cys Cys Leu Arg Lys Gly 
65                  70                  75                  80  


Glu Ser Gly Gln Ser Trp Pro Arg Leu Thr Lys Glu Arg Ala Lys Leu 
                85                  90                  95      


Asn Trp Leu Ser Val Asp Phe Asn Asn Trp Lys Asp Trp Glu Asp Asp 
            100                 105                 110         


Ser Asp Glu Asp Met Ser Asn Phe Asp Arg Phe Ser Glu Met Met Asn 
        115                 120                 125             


Asn Met Gly Gly Asp Glu Asp Val Asp Leu Pro Glu Val Asp Gly Ala 
    130                 135                 140                 


Asp Asp Asp Ser Gln Asp Ser Asp Asp Glu Lys Met Pro Asp Leu Glu 
145                 150                 155                 160 


<210>  38
<211>  225
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P24534
<309>  1993-04-23
<313>  (1)..(225)

<400>  38

Met Gly Phe Gly Asp Leu Lys Ser Pro Ala Gly Leu Gln Val Leu Asn 
1               5                   10                  15      


Asp Tyr Leu Ala Asp Lys Ser Tyr Ile Glu Gly Tyr Val Pro Ser Gln 
            20                  25                  30          


Ala Asp Val Ala Val Phe Glu Ala Val Ser Ser Pro Pro Pro Ala Asp 
        35                  40                  45              


Leu Cys His Ala Leu Arg Trp Tyr Asn His Ile Lys Ser Tyr Glu Lys 
    50                  55                  60                  


Glu Lys Ala Ser Leu Pro Gly Val Lys Lys Ala Leu Gly Lys Tyr Gly 
65                  70                  75                  80  


Pro Ala Asp Val Glu Asp Thr Thr Gly Ser Gly Ala Thr Asp Ser Lys 
                85                  90                  95      


Asp Asp Asp Asp Ile Asp Leu Phe Gly Ser Asp Asp Glu Glu Glu Ser 
            100                 105                 110         


Glu Glu Ala Lys Arg Leu Arg Glu Glu Arg Leu Ala Gln Tyr Glu Ser 
        115                 120                 125             


Lys Lys Ala Lys Lys Pro Ala Leu Val Ala Lys Ser Ser Ile Leu Leu 
    130                 135                 140                 


Asp Val Lys Pro Trp Asp Asp Glu Thr Asp Met Ala Lys Leu Glu Glu 
145                 150                 155                 160 


Cys Val Arg Ser Ile Gln Ala Asp Gly Leu Val Trp Gly Ser Ser Lys 
                165                 170                 175     


Leu Val Pro Val Gly Tyr Gly Ile Lys Lys Leu Gln Ile Gln Cys Val 
            180                 185                 190         


Val Glu Asp Asp Lys Val Gly Thr Asp Met Leu Glu Glu Gln Ile Thr 
        195                 200                 205             


Ala Phe Glu Asp Tyr Val Gln Ser Met Asp Val Ala Ala Phe Asn Lys 
    210                 215                 220                 


Ile 
225 


<210>  39
<211>  324
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P67809
<309>  2016-09-07
<313>  (1)..(324)

<400>  39

Met Ser Ser Glu Ala Glu Thr Gln Gln Pro Pro Ala Ala Pro Pro Ala 
1               5                   10                  15      


Ala Pro Ala Leu Ser Ala Ala Asp Thr Lys Pro Gly Thr Thr Gly Ser 
            20                  25                  30          


Gly Ala Gly Ser Gly Gly Pro Gly Gly Leu Thr Ser Ala Ala Pro Ala 
        35                  40                  45              


Gly Gly Asp Lys Lys Val Ile Ala Thr Lys Val Leu Gly Thr Val Lys 
    50                  55                  60                  


Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr 
65                  70                  75                  80  


Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro 
                85                  90                  95      


Arg Lys Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp 
            100                 105                 110         


Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro 
        115                 120                 125             


Gly Gly Val Pro Val Gln Gly Ser Lys Tyr Ala Ala Asp Arg Asn His 
    130                 135                 140                 


Tyr Arg Arg Tyr Pro Arg Arg Arg Gly Pro Pro Arg Asn Tyr Gln Gln 
145                 150                 155                 160 


Asn Tyr Gln Asn Ser Glu Ser Gly Glu Lys Asn Glu Gly Ser Glu Ser 
                165                 170                 175     


Ala Pro Glu Gly Gln Ala Gln Gln Arg Arg Pro Tyr Arg Arg Arg Arg 
            180                 185                 190         


Phe Pro Pro Tyr Tyr Met Arg Arg Pro Tyr Gly Arg Arg Pro Gln Tyr 
        195                 200                 205             


Ser Asn Pro Pro Val Gln Gly Glu Val Met Glu Gly Ala Asp Asn Gln 
    210                 215                 220                 


Gly Ala Gly Glu Gln Gly Arg Pro Val Arg Gln Asn Met Tyr Arg Gly 
225                 230                 235                 240 


Tyr Arg Pro Arg Phe Arg Arg Gly Pro Pro Arg Gln Arg Gln Pro Arg 
                245                 250                 255     


Glu Asp Gly Asn Glu Glu Asp Lys Glu Asn Gln Gly Asp Glu Thr Gln 
            260                 265                 270         


Gly Gln Gln Pro Pro Gln Arg Arg Tyr Arg Arg Asn Phe Asn Tyr Arg 
        275                 280                 285             


Arg Arg Arg Pro Glu Asn Pro Lys Pro Gln Asp Gly Lys Glu Thr Lys 
    290                 295                 300                 


Ala Ala Asp Pro Pro Ala Glu Asn Ser Ser Ala Pro Glu Ala Glu Gln 
305                 310                 315                 320 


Gly Gly Ala Glu 
                


<210>  40
<211>  539
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P50991
<309>  2016-09-07
<313>  (1)..(539)

<400>  40

Met Pro Glu Asn Val Ala Pro Arg Ser Gly Ala Thr Ala Gly Ala Ala 
1               5                   10                  15      


Gly Gly Arg Gly Lys Gly Ala Tyr Gln Asp Arg Asp Lys Pro Ala Gln 
            20                  25                  30          


Ile Arg Phe Ser Asn Ile Ser Ala Ala Lys Ala Val Ala Asp Ala Ile 
        35                  40                  45              


Arg Thr Ser Leu Gly Pro Lys Gly Met Asp Lys Met Ile Gln Asp Gly 
    50                  55                  60                  


Lys Gly Asp Val Thr Ile Thr Asn Asp Gly Ala Thr Ile Leu Lys Gln 
65                  70                  75                  80  


Met Gln Val Leu His Pro Ala Ala Arg Met Leu Val Glu Leu Ser Lys 
                85                  90                  95      


Ala Gln Asp Ile Glu Ala Gly Asp Gly Thr Thr Ser Val Val Ile Ile 
            100                 105                 110         


Ala Gly Ser Leu Leu Asp Ser Cys Thr Lys Leu Leu Gln Lys Gly Ile 
        115                 120                 125             


His Pro Thr Ile Ile Ser Glu Ser Phe Gln Lys Ala Leu Glu Lys Gly 
    130                 135                 140                 


Ile Glu Ile Leu Thr Asp Met Ser Arg Pro Val Glu Leu Ser Asp Arg 
145                 150                 155                 160 


Glu Thr Leu Leu Asn Ser Ala Thr Thr Ser Leu Asn Ser Lys Val Val 
                165                 170                 175     


Ser Gln Tyr Ser Ser Leu Leu Ser Pro Met Ser Val Asn Ala Val Met 
            180                 185                 190         


Lys Val Ile Asp Pro Ala Thr Ala Thr Ser Val Asp Leu Arg Asp Ile 
        195                 200                 205             


Lys Ile Val Lys Lys Leu Gly Gly Thr Ile Asp Asp Cys Glu Leu Val 
    210                 215                 220                 


Glu Gly Leu Val Leu Thr Gln Lys Val Ser Asn Ser Gly Ile Thr Arg 
225                 230                 235                 240 


Val Glu Lys Ala Lys Ile Gly Leu Ile Gln Phe Cys Leu Ser Ala Pro 
                245                 250                 255     


Lys Thr Asp Met Asp Asn Gln Ile Val Val Ser Asp Tyr Ala Gln Met 
            260                 265                 270         


Asp Arg Val Leu Arg Glu Glu Arg Ala Tyr Ile Leu Asn Leu Val Lys 
        275                 280                 285             


Gln Ile Lys Lys Thr Gly Cys Asn Val Leu Leu Ile Gln Lys Ser Ile 
    290                 295                 300                 


Leu Arg Asp Ala Leu Ser Asp Leu Ala Leu His Phe Leu Asn Lys Met 
305                 310                 315                 320 


Lys Ile Met Val Ile Lys Asp Ile Glu Arg Glu Asp Ile Glu Phe Ile 
                325                 330                 335     


Cys Lys Thr Ile Gly Thr Lys Pro Val Ala His Ile Asp Gln Phe Thr 
            340                 345                 350         


Ala Asp Met Leu Gly Ser Ala Glu Leu Ala Glu Glu Val Asn Leu Asn 
        355                 360                 365             


Gly Ser Gly Lys Leu Leu Lys Ile Thr Gly Cys Ala Ser Pro Gly Lys 
    370                 375                 380                 


Thr Val Thr Ile Val Val Arg Gly Ser Asn Lys Leu Val Ile Glu Glu 
385                 390                 395                 400 


Ala Glu Arg Ser Ile His Asp Ala Leu Cys Val Ile Arg Cys Leu Val 
                405                 410                 415     


Lys Lys Arg Ala Leu Ile Ala Gly Gly Gly Ala Pro Glu Ile Glu Leu 
            420                 425                 430         


Ala Leu Arg Leu Thr Glu Tyr Ser Arg Thr Leu Ser Gly Met Glu Ser 
        435                 440                 445             


Tyr Cys Val Arg Ala Phe Ala Asp Ala Met Glu Val Ile Pro Ser Thr 
    450                 455                 460                 


Leu Ala Glu Asn Ala Gly Leu Asn Pro Ile Ser Thr Val Thr Glu Leu 
465                 470                 475                 480 


Arg Asn Arg His Ala Gln Gly Glu Lys Thr Ala Gly Ile Asn Val Arg 
                485                 490                 495     


Lys Gly Gly Ile Ser Asn Ile Leu Glu Glu Leu Val Val Gln Pro Leu 
            500                 505                 510         


Leu Val Ser Val Ser Ala Leu Thr Leu Ala Thr Glu Thr Val Arg Ser 
        515                 520                 525             


Ile Leu Lys Ile Asp Asp Val Val Asn Thr Arg 
    530                 535                 


<210>  41
<211>  1274
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q92797
<309>  2016-09-07
<313>  (1)..(1274)

<400>  41

Met Ala Ser Gly Ser Gly Asp Ser Val Thr Arg Arg Ser Val Ala Ser 
1               5                   10                  15      


Gln Phe Phe Thr Gln Glu Glu Gly Pro Gly Ile Asp Gly Met Thr Thr 
            20                  25                  30          


Ser Glu Arg Val Val Asp Leu Leu Asn Gln Ala Ala Leu Ile Thr Asn 
        35                  40                  45              


Asp Ser Lys Ile Thr Val Leu Lys Gln Val Gln Glu Leu Ile Ile Asn 
    50                  55                  60                  


Lys Asp Pro Thr Leu Leu Asp Asn Phe Leu Asp Glu Ile Ile Ala Phe 
65                  70                  75                  80  


Gln Ala Asp Lys Ser Ile Glu Val Arg Lys Phe Val Ile Gly Phe Ile 
                85                  90                  95      


Glu Glu Ala Cys Lys Arg Asp Ile Glu Leu Leu Leu Lys Leu Ile Ala 
            100                 105                 110         


Asn Leu Asn Met Leu Leu Arg Asp Glu Asn Val Asn Val Val Lys Lys 
        115                 120                 125             


Ala Ile Leu Thr Met Thr Gln Leu Tyr Lys Val Ala Leu Gln Trp Met 
    130                 135                 140                 


Val Lys Ser Arg Val Ile Ser Glu Leu Gln Glu Ala Cys Trp Asp Met 
145                 150                 155                 160 


Val Ser Ala Met Ala Gly Asp Ile Ile Leu Leu Leu Asp Ser Asp Asn 
                165                 170                 175     


Asp Gly Ile Arg Thr His Ala Ile Lys Phe Val Glu Gly Leu Ile Val 
            180                 185                 190         


Thr Leu Ser Pro Arg Met Ala Asp Ser Glu Ile Pro Arg Arg Gln Glu 
        195                 200                 205             


His Asp Ile Ser Leu Asp Arg Ile Pro Arg Asp His Pro Tyr Ile Gln 
    210                 215                 220                 


Tyr Asn Val Leu Trp Glu Glu Gly Lys Ala Ala Leu Glu Gln Leu Leu 
225                 230                 235                 240 


Lys Phe Met Val His Pro Ala Ile Ser Ser Ile Asn Leu Thr Thr Ala 
                245                 250                 255     


Leu Gly Ser Leu Ala Asn Ile Ala Arg Gln Arg Pro Met Phe Met Ser 
            260                 265                 270         


Glu Val Ile Gln Ala Tyr Glu Thr Leu His Ala Asn Leu Pro Pro Thr 
        275                 280                 285             


Leu Ala Lys Ser Gln Val Ser Ser Val Arg Lys Asn Leu Lys Leu His 
    290                 295                 300                 


Leu Leu Ser Val Leu Lys His Pro Ala Ser Leu Glu Phe Gln Ala Gln 
305                 310                 315                 320 


Ile Thr Thr Leu Leu Val Asp Leu Gly Thr Pro Gln Ala Glu Ile Ala 
                325                 330                 335     


Arg Asn Met Pro Ser Ser Lys Asp Thr Arg Lys Arg Pro Arg Asp Asp 
            340                 345                 350         


Ser Asp Ser Thr Leu Lys Lys Met Lys Leu Glu Pro Asn Leu Gly Glu 
        355                 360                 365             


Asp Asp Glu Asp Lys Asp Leu Glu Pro Gly Pro Ser Gly Thr Ser Lys 
    370                 375                 380                 


Ala Ser Ala Gln Ile Ser Gly Gln Ser Asp Thr Asp Ile Thr Ala Glu 
385                 390                 395                 400 


Phe Leu Gln Pro Leu Leu Thr Pro Asp Asn Val Ala Asn Leu Val Leu 
                405                 410                 415     


Ile Ser Met Val Tyr Leu Pro Glu Ala Met Pro Ala Ser Phe Gln Ala 
            420                 425                 430         


Ile Tyr Thr Pro Val Glu Ser Ala Gly Thr Glu Ala Gln Ile Lys His 
        435                 440                 445             


Leu Ala Arg Leu Met Ala Thr Gln Met Thr Ala Ala Gly Leu Gly Pro 
    450                 455                 460                 


Gly Val Glu Gln Thr Lys Gln Cys Lys Glu Glu Pro Lys Glu Glu Lys 
465                 470                 475                 480 


Val Val Lys Thr Glu Ser Val Leu Ile Lys Arg Arg Leu Ser Ala Gln 
                485                 490                 495     


Gly Gln Ala Ile Ser Val Val Gly Ser Leu Ser Ser Met Ser Pro Leu 
            500                 505                 510         


Glu Glu Glu Ala Pro Gln Ala Lys Arg Arg Pro Glu Pro Ile Ile Pro 
        515                 520                 525             


Val Thr Gln Pro Arg Leu Ala Gly Ala Gly Gly Arg Lys Lys Ile Phe 
    530                 535                 540                 


Arg Leu Ser Asp Val Leu Lys Pro Leu Thr Asp Ala Gln Val Glu Ala 
545                 550                 555                 560 


Met Lys Leu Gly Ala Val Lys Arg Ile Leu Arg Ala Glu Lys Ala Val 
                565                 570                 575     


Ala Cys Ser Gly Ala Ala Gln Val Arg Ile Lys Ile Leu Ala Ser Leu 
            580                 585                 590         


Val Thr Gln Phe Asn Ser Gly Leu Lys Ala Glu Val Leu Ser Phe Ile 
        595                 600                 605             


Leu Glu Asp Val Arg Ala Arg Leu Asp Leu Ala Phe Ala Trp Leu Tyr 
    610                 615                 620                 


Gln Glu Tyr Asn Ala Tyr Leu Ala Ala Gly Ala Ser Gly Ser Leu Asp 
625                 630                 635                 640 


Lys Tyr Glu Asp Cys Leu Ile Arg Leu Leu Ser Gly Leu Gln Glu Lys 
                645                 650                 655     


Pro Asp Gln Lys Asp Gly Ile Phe Thr Lys Val Val Leu Glu Ala Pro 
            660                 665                 670         


Leu Ile Thr Glu Ser Ala Leu Glu Val Val Arg Lys Tyr Cys Glu Asp 
        675                 680                 685             


Glu Ser Arg Thr Tyr Leu Gly Met Ser Thr Leu Arg Asp Leu Ile Phe 
    690                 695                 700                 


Lys Arg Pro Ser Arg Gln Phe Gln Tyr Leu His Val Leu Leu Asp Leu 
705                 710                 715                 720 


Ser Ser His Glu Lys Asp Lys Val Arg Ser Gln Ala Leu Leu Phe Ile 
                725                 730                 735     


Lys Arg Met Tyr Glu Lys Glu Gln Leu Arg Glu Tyr Val Glu Lys Phe 
            740                 745                 750         


Ala Leu Asn Tyr Leu Gln Leu Leu Val His Pro Asn Pro Pro Ser Val 
        755                 760                 765             


Leu Phe Gly Ala Asp Lys Asp Thr Glu Val Ala Ala Pro Trp Thr Glu 
    770                 775                 780                 


Glu Thr Val Lys Gln Cys Leu Tyr Leu Tyr Leu Ala Leu Leu Pro Gln 
785                 790                 795                 800 


Asn His Lys Leu Ile His Glu Leu Ala Ala Val Tyr Thr Glu Ala Ile 
                805                 810                 815     


Ala Asp Ile Lys Arg Thr Val Leu Arg Val Ile Glu Gln Pro Ile Arg 
            820                 825                 830         


Gly Met Gly Met Asn Ser Pro Glu Leu Leu Leu Leu Val Glu Asn Cys 
        835                 840                 845             


Pro Lys Gly Ala Glu Thr Leu Val Thr Arg Cys Leu His Ser Leu Thr 
    850                 855                 860                 


Asp Lys Val Pro Pro Ser Pro Glu Leu Val Lys Arg Val Arg Asp Leu 
865                 870                 875                 880 


Tyr His Lys Arg Leu Pro Asp Val Arg Phe Leu Ile Pro Val Leu Asn 
                885                 890                 895     


Gly Leu Glu Lys Lys Glu Val Ile Gln Ala Leu Pro Lys Leu Ile Lys 
            900                 905                 910         


Leu Asn Pro Ile Val Val Lys Glu Val Phe Asn Arg Leu Leu Gly Thr 
        915                 920                 925             


Gln His Gly Glu Gly Asn Ser Ala Leu Ser Pro Leu Asn Pro Gly Glu 
    930                 935                 940                 


Leu Leu Ile Ala Leu His Asn Ile Asp Ser Val Lys Cys Asp Met Lys 
945                 950                 955                 960 


Ser Ile Ile Lys Ala Thr Asn Leu Cys Phe Ala Glu Arg Asn Val Tyr 
                965                 970                 975     


Thr Ser Glu Val Leu Ala Val Val Met Gln Gln Leu Met Glu Gln Ser 
            980                 985                 990         


Pro Leu Pro Met Leu Leu Met Arg  Thr Val Ile Gln Ser  Leu Thr Met 
        995                 1000                 1005             


Tyr Pro  Arg Leu Gly Gly Phe  Val Met Asn Ile Leu  Ser Arg Leu 
    1010                 1015                 1020             


Ile Met  Lys Gln Val Trp Lys  Tyr Pro Lys Val Trp  Glu Gly Phe 
    1025                 1030                 1035             


Ile Lys  Cys Cys Gln Arg Thr  Lys Pro Gln Ser Phe  Gln Val Ile 
    1040                 1045                 1050             


Leu Gln  Leu Pro Pro Gln Gln  Leu Gly Ala Val Phe  Asp Lys Cys 
    1055                 1060                 1065             


Pro Glu  Leu Arg Glu Pro Leu  Leu Ala His Val Arg  Ser Phe Thr 
    1070                 1075                 1080             


Pro His  Gln Gln Ala His Ile  Pro Asn Ser Ile Met  Thr Ile Leu 
    1085                 1090                 1095             


Glu Ala  Ser Gly Lys Gln Glu  Pro Glu Ala Lys Glu  Ala Pro Ala 
    1100                 1105                 1110             


Gly Pro  Leu Glu Glu Asp Asp  Leu Glu Pro Leu Thr  Leu Ala Pro 
    1115                 1120                 1125             


Ala Pro  Ala Pro Arg Pro Pro  Gln Asp Leu Ile Gly  Leu Arg Leu 
    1130                 1135                 1140             


Ala Gln  Glu Lys Ala Leu Lys  Arg Gln Leu Glu Glu  Glu Gln Lys 
    1145                 1150                 1155             


Leu Lys  Pro Gly Gly Val Gly  Ala Pro Ser Ser Ser  Ser Pro Ser 
    1160                 1165                 1170             


Pro Ser  Pro Ser Ala Arg Pro  Gly Pro Pro Pro Ser  Glu Glu Ala 
    1175                 1180                 1185             


Met Asp  Phe Arg Glu Glu Gly  Pro Glu Cys Glu Thr  Pro Gly Ile 
    1190                 1195                 1200             


Phe Ile  Ser Met Asp Asp Asp  Ser Gly Leu Thr Glu  Ala Ala Leu 
    1205                 1210                 1215             


Leu Asp  Ser Ser Leu Glu Gly  Pro Leu Pro Lys Glu  Thr Ala Ala 
    1220                 1225                 1230             


Gly Gly  Leu Thr Leu Lys Glu  Glu Arg Ser Pro Gln  Thr Leu Ala 
    1235                 1240                 1245             


Pro Val  Gly Glu Asp Ala Met  Lys Thr Pro Ser Pro  Ala Ala Glu 
    1250                 1255                 1260             


Asp Ala  Arg Glu Pro Glu Ala  Lys Gly Asn Ser 
    1265                 1270                 


<210>  42
<211>  592
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q92804
<309>  2016-07-09
<313>  (1)..(592)

<400>  42

Met Ser Asp Ser Gly Ser Tyr Gly Gln Ser Gly Gly Glu Gln Gln Ser 
1               5                   10                  15      


Tyr Ser Thr Tyr Gly Asn Pro Gly Ser Gln Gly Tyr Gly Gln Ala Ser 
            20                  25                  30          


Gln Ser Tyr Ser Gly Tyr Gly Gln Thr Thr Asp Ser Ser Tyr Gly Gln 
        35                  40                  45              


Asn Tyr Ser Gly Tyr Ser Ser Tyr Gly Gln Ser Gln Ser Gly Tyr Ser 
    50                  55                  60                  


Gln Ser Tyr Gly Gly Tyr Glu Asn Gln Lys Gln Ser Ser Tyr Ser Gln 
65                  70                  75                  80  


Gln Pro Tyr Asn Asn Gln Gly Gln Gln Gln Asn Met Glu Ser Ser Gly 
                85                  90                  95      


Ser Gln Gly Gly Arg Ala Pro Ser Tyr Asp Gln Pro Asp Tyr Gly Gln 
            100                 105                 110         


Gln Asp Ser Tyr Asp Gln Gln Ser Gly Tyr Asp Gln His Gln Gly Ser 
        115                 120                 125             


Tyr Asp Glu Gln Ser Asn Tyr Asp Gln Gln His Asp Ser Tyr Ser Gln 
    130                 135                 140                 


Asn Gln Gln Ser Tyr His Ser Gln Arg Glu Asn Tyr Ser His His Thr 
145                 150                 155                 160 


Gln Asp Asp Arg Arg Asp Val Ser Arg Tyr Gly Glu Asp Asn Arg Gly 
                165                 170                 175     


Tyr Gly Gly Ser Gln Gly Gly Gly Arg Gly Arg Gly Gly Tyr Asp Lys 
            180                 185                 190         


Asp Gly Arg Gly Pro Met Thr Gly Ser Ser Gly Gly Asp Arg Gly Gly 
        195                 200                 205             


Phe Lys Asn Phe Gly Gly His Arg Asp Tyr Gly Pro Arg Thr Asp Ala 
    210                 215                 220                 


Asp Ser Glu Ser Asp Asn Ser Asp Asn Asn Thr Ile Phe Val Gln Gly 
225                 230                 235                 240 


Leu Gly Glu Gly Val Ser Thr Asp Gln Val Gly Glu Phe Phe Lys Gln 
                245                 250                 255     


Ile Gly Ile Ile Lys Thr Asn Lys Lys Thr Gly Lys Pro Met Ile Asn 
            260                 265                 270         


Leu Tyr Thr Asp Lys Asp Thr Gly Lys Pro Lys Gly Glu Ala Thr Val 
        275                 280                 285             


Ser Phe Asp Asp Pro Pro Ser Ala Lys Ala Ala Ile Asp Trp Phe Asp 
    290                 295                 300                 


Gly Lys Glu Phe His Gly Asn Ile Ile Lys Val Ser Phe Ala Thr Arg 
305                 310                 315                 320 


Arg Pro Glu Phe Met Arg Gly Gly Gly Ser Gly Gly Gly Arg Arg Gly 
                325                 330                 335     


Arg Gly Gly Tyr Arg Gly Arg Gly Gly Phe Gln Gly Arg Gly Gly Asp 
            340                 345                 350         


Pro Lys Ser Gly Asp Trp Val Cys Pro Asn Pro Ser Cys Gly Asn Met 
        355                 360                 365             


Asn Phe Ala Arg Arg Asn Ser Cys Asn Gln Cys Asn Glu Pro Arg Pro 
    370                 375                 380                 


Glu Asp Ser Arg Pro Ser Gly Gly Asp Phe Arg Gly Arg Gly Tyr Gly 
385                 390                 395                 400 


Gly Glu Arg Gly Tyr Arg Gly Arg Gly Gly Arg Gly Gly Asp Arg Gly 
                405                 410                 415     


Gly Tyr Gly Gly Asp Arg Ser Gly Gly Gly Tyr Gly Gly Asp Arg Ser 
            420                 425                 430         


Ser Gly Gly Gly Tyr Ser Gly Asp Arg Ser Gly Gly Gly Tyr Gly Gly 
        435                 440                 445             


Asp Arg Ser Gly Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Tyr Gly 
    450                 455                 460                 


Gly Asp Arg Gly Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Tyr Gly 
465                 470                 475                 480 


Gly Asp Arg Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Tyr Gly Gly 
                485                 490                 495     


Asp Arg Gly Gly Tyr Gly Gly Asp Arg Gly Gly Tyr Gly Gly Asp Arg 
            500                 505                 510         


Gly Gly Tyr Gly Gly Asp Arg Gly Gly Tyr Gly Gly Asp Arg Ser Arg 
        515                 520                 525             


Gly Gly Tyr Gly Gly Asp Arg Gly Gly Gly Ser Gly Tyr Gly Gly Asp 
    530                 535                 540                 


Arg Ser Gly Gly Tyr Gly Gly Asp Arg Ser Gly Gly Gly Tyr Gly Gly 
545                 550                 555                 560 


Asp Arg Gly Gly Gly Tyr Gly Gly Asp Arg Gly Gly Tyr Gly Gly Lys 
                565                 570                 575     


Met Gly Gly Arg Asn Asp Tyr Arg Asn Asp Gln Arg Asn Arg Pro Tyr 
            580                 585                 590         


<210>  43
<211>  206
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P30043
<309>  1993-05-14
<313>  (1)..(206)

<400>  43

Met Ala Val Lys Lys Ile Ala Ile Phe Gly Ala Thr Gly Gln Thr Gly 
1               5                   10                  15      


Leu Thr Thr Leu Ala Gln Ala Val Gln Ala Gly Tyr Glu Val Thr Val 
            20                  25                  30          


Leu Val Arg Asp Ser Ser Arg Leu Pro Ser Glu Gly Pro Arg Pro Ala 
        35                  40                  45              


His Val Val Val Gly Asp Val Leu Gln Ala Ala Asp Val Asp Lys Thr 
    50                  55                  60                  


Val Ala Gly Gln Asp Ala Val Ile Val Leu Leu Gly Thr Arg Asn Asp 
65                  70                  75                  80  


Leu Ser Pro Thr Thr Val Met Ser Glu Gly Ala Arg Asn Ile Val Ala 
                85                  90                  95      


Ala Met Lys Ala His Gly Val Asp Lys Val Val Ala Cys Thr Ser Ala 
            100                 105                 110         


Phe Leu Leu Trp Asp Pro Thr Lys Val Pro Pro Arg Leu Gln Ala Val 
        115                 120                 125             


Thr Asp Asp His Ile Arg Met His Lys Val Leu Arg Glu Ser Gly Leu 
    130                 135                 140                 


Lys Tyr Val Ala Val Met Pro Pro His Ile Gly Asp Gln Pro Leu Thr 
145                 150                 155                 160 


Gly Ala Tyr Thr Val Thr Leu Asp Gly Arg Gly Pro Ser Arg Val Ile 
                165                 170                 175     


Ser Lys His Asp Leu Gly His Phe Met Leu Arg Cys Leu Thr Thr Asp 
            180                 185                 190         


Glu Tyr Asp Gly His Ser Thr Tyr Pro Ser His Gln Tyr Gln 
        195                 200                 205     


<210>  44
<211>  449
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P31943
<309>  1993-09-15
<313>  (1)..(449)

<400>  44

Met Met Leu Gly Thr Glu Gly Gly Glu Gly Phe Val Val Lys Val Arg 
1               5                   10                  15      


Gly Leu Pro Trp Ser Cys Ser Ala Asp Glu Val Gln Arg Phe Phe Ser 
            20                  25                  30          


Asp Cys Lys Ile Gln Asn Gly Ala Gln Gly Ile Arg Phe Ile Tyr Thr 
        35                  40                  45              


Arg Glu Gly Arg Pro Ser Gly Glu Ala Phe Val Glu Leu Glu Ser Glu 
    50                  55                  60                  


Asp Glu Val Lys Leu Ala Leu Lys Lys Asp Arg Glu Thr Met Gly His 
65                  70                  75                  80  


Arg Tyr Val Glu Val Phe Lys Ser Asn Asn Val Glu Met Asp Trp Val 
                85                  90                  95      


Leu Lys His Thr Gly Pro Asn Ser Pro Asp Thr Ala Asn Asp Gly Phe 
            100                 105                 110         


Val Arg Leu Arg Gly Leu Pro Phe Gly Cys Ser Lys Glu Glu Ile Val 
        115                 120                 125             


Gln Phe Phe Ser Gly Leu Glu Ile Val Pro Asn Gly Ile Thr Leu Pro 
    130                 135                 140                 


Val Asp Phe Gln Gly Arg Ser Thr Gly Glu Ala Phe Val Gln Phe Ala 
145                 150                 155                 160 


Ser Gln Glu Ile Ala Glu Lys Ala Leu Lys Lys His Lys Glu Arg Ile 
                165                 170                 175     


Gly His Arg Tyr Ile Glu Ile Phe Lys Ser Ser Arg Ala Glu Val Arg 
            180                 185                 190         


Thr His Tyr Asp Pro Pro Arg Lys Leu Met Ala Met Gln Arg Pro Gly 
        195                 200                 205             


Pro Tyr Asp Arg Pro Gly Ala Gly Arg Gly Tyr Asn Ser Ile Gly Arg 
    210                 215                 220                 


Gly Ala Gly Phe Glu Arg Met Arg Arg Gly Ala Tyr Gly Gly Gly Tyr 
225                 230                 235                 240 


Gly Gly Tyr Asp Asp Tyr Asn Gly Tyr Asn Asp Gly Tyr Gly Phe Gly 
                245                 250                 255     


Ser Asp Arg Phe Gly Arg Asp Leu Asn Tyr Cys Phe Ser Gly Met Ser 
            260                 265                 270         


Asp His Arg Tyr Gly Asp Gly Gly Ser Thr Phe Gln Ser Thr Thr Gly 
        275                 280                 285             


His Cys Val His Met Arg Gly Leu Pro Tyr Arg Ala Thr Glu Asn Asp 
    290                 295                 300                 


Ile Tyr Asn Phe Phe Ser Pro Leu Asn Pro Val Arg Val His Ile Glu 
305                 310                 315                 320 


Ile Gly Pro Asp Gly Arg Val Thr Gly Glu Ala Asp Val Glu Phe Ala 
                325                 330                 335     


Thr His Glu Asp Ala Val Ala Ala Met Ser Lys Asp Lys Ala Asn Met 
            340                 345                 350         


Gln His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr Ala Gly Ala Ser 
        355                 360                 365             


Gly Gly Ala Tyr Glu His Arg Tyr Val Glu Leu Phe Leu Asn Ser Thr 
    370                 375                 380                 


Ala Gly Ala Ser Gly Gly Ala Tyr Gly Ser Gln Met Met Gly Gly Met 
385                 390                 395                 400 


Gly Leu Ser Asn Gln Ser Ser Tyr Gly Gly Pro Ala Ser Gln Gln Leu 
                405                 410                 415     


Ser Gly Gly Tyr Gly Gly Gly Tyr Gly Gly Gln Ser Ser Met Ser Gly 
            420                 425                 430         


Tyr Asp Gln Val Leu Gln Glu Asn Ser Ser Asp Phe Gln Ser Asn Ile 
        435                 440                 445             


Ala 
    


<210>  45
<211>  306
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P07910
<309>  1993-04-24
<313>  (1)..(306)

<400>  45

Met Ala Ser Asn Val Thr Asn Lys Thr Asp Pro Arg Ser Met Asn Ser 
1               5                   10                  15      


Arg Val Phe Ile Gly Asn Leu Asn Thr Leu Val Val Lys Lys Ser Asp 
            20                  25                  30          


Val Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Val Gly Cys Ser Val 
        35                  40                  45              


His Lys Gly Phe Ala Phe Val Gln Tyr Val Asn Glu Arg Asn Ala Arg 
    50                  55                  60                  


Ala Ala Val Ala Gly Glu Asp Gly Arg Met Ile Ala Gly Gln Val Leu 
65                  70                  75                  80  


Asp Ile Asn Leu Ala Ala Glu Pro Lys Val Asn Arg Gly Lys Ala Gly 
                85                  90                  95      


Val Lys Arg Ser Ala Ala Glu Met Tyr Gly Ser Val Thr Glu His Pro 
            100                 105                 110         


Ser Pro Ser Pro Leu Leu Ser Ser Ser Phe Asp Leu Asp Tyr Asp Phe 
        115                 120                 125             


Gln Arg Asp Tyr Tyr Asp Arg Met Tyr Ser Tyr Pro Ala Arg Val Pro 
    130                 135                 140                 


Pro Pro Pro Pro Ile Ala Arg Ala Val Val Pro Ser Lys Arg Gln Arg 
145                 150                 155                 160 


Val Ser Gly Asn Thr Ser Arg Arg Gly Lys Ser Gly Phe Asn Ser Lys 
                165                 170                 175     


Ser Gly Gln Arg Gly Ser Ser Lys Ser Gly Lys Leu Lys Gly Asp Asp 
            180                 185                 190         


Leu Gln Ala Ile Lys Lys Glu Leu Thr Gln Ile Lys Gln Lys Val Asp 
        195                 200                 205             


Ser Leu Leu Glu Asn Leu Glu Lys Ile Glu Lys Glu Gln Ser Lys Gln 
    210                 215                 220                 


Ala Val Glu Met Lys Asn Asp Lys Ser Glu Glu Glu Gln Ser Ser Ser 
225                 230                 235                 240 


Ser Val Lys Lys Asp Glu Thr Asn Val Lys Met Glu Ser Glu Gly Gly 
                245                 250                 255     


Ala Asp Asp Ser Ala Glu Glu Gly Asp Leu Leu Asp Asp Asp Asp Asn 
            260                 265                 270         


Glu Asp Arg Gly Asp Asp Gln Leu Glu Leu Ile Lys Asp Asp Glu Lys 
        275                 280                 285             


Glu Ala Glu Glu Gly Glu Asp Asp Arg Asp Ser Ala Asn Gly Glu Asp 
    290                 295                 300                 


Asp Ser 
305     


<210>  46
<211>  610
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O15213
<309>  2002-04-11
<313>  (1)..(610)

<400>  46

Met Glu Thr Ala Pro Lys Pro Gly Lys Asp Val Pro Pro Lys Lys Asp 
1               5                   10                  15      


Lys Leu Gln Thr Lys Arg Lys Lys Pro Arg Arg Tyr Trp Glu Glu Glu 
            20                  25                  30          


Thr Val Pro Thr Thr Ala Gly Ala Ser Pro Gly Pro Pro Arg Asn Lys 
        35                  40                  45              


Lys Asn Arg Glu Leu Arg Pro Gln Arg Pro Lys Asn Ala Tyr Ile Leu 
    50                  55                  60                  


Lys Lys Ser Arg Ile Ser Lys Lys Pro Gln Val Pro Lys Lys Pro Arg 
65                  70                  75                  80  


Glu Trp Lys Asn Pro Glu Ser Gln Arg Gly Leu Ser Gly Thr Gln Asp 
                85                  90                  95      


Pro Phe Pro Gly Pro Ala Pro Val Pro Val Glu Val Val Gln Lys Phe 
            100                 105                 110         


Cys Arg Ile Asp Lys Ser Arg Lys Leu Pro His Ser Lys Ala Lys Thr 
        115                 120                 125             


Arg Ser Arg Leu Glu Val Ala Glu Ala Glu Glu Glu Glu Thr Ser Ile 
    130                 135                 140                 


Lys Ala Ala Arg Ser Glu Leu Leu Leu Ala Glu Glu Pro Gly Phe Leu 
145                 150                 155                 160 


Glu Gly Glu Asp Gly Glu Asp Thr Ala Lys Ile Cys Gln Ala Asp Ile 
                165                 170                 175     


Val Glu Ala Val Asp Ile Ala Ser Ala Ala Lys His Phe Asp Leu Asn 
            180                 185                 190         


Leu Arg Gln Phe Gly Pro Tyr Arg Leu Asn Tyr Ser Arg Thr Gly Arg 
        195                 200                 205             


His Leu Ala Phe Gly Gly Arg Arg Gly His Val Ala Ala Leu Asp Trp 
    210                 215                 220                 


Val Thr Lys Lys Leu Met Cys Glu Ile Asn Val Met Glu Ala Val Arg 
225                 230                 235                 240 


Asp Ile Arg Phe Leu His Ser Glu Ala Leu Leu Ala Val Ala Gln Asn 
                245                 250                 255     


Arg Trp Leu His Ile Tyr Asp Asn Gln Gly Ile Glu Leu His Cys Ile 
            260                 265                 270         


Arg Arg Cys Asp Arg Val Thr Arg Leu Glu Phe Leu Pro Phe His Phe 
        275                 280                 285             


Leu Leu Ala Thr Ala Ser Glu Thr Gly Phe Leu Thr Tyr Leu Asp Val 
    290                 295                 300                 


Ser Val Gly Lys Ile Val Ala Ala Leu Asn Ala Arg Ala Gly Arg Leu 
305                 310                 315                 320 


Asp Val Met Ser Gln Asn Pro Tyr Asn Ala Val Ile His Leu Gly His 
                325                 330                 335     


Ser Asn Gly Thr Val Ser Leu Trp Ser Pro Ala Met Lys Glu Pro Leu 
            340                 345                 350         


Ala Lys Ile Leu Cys His Arg Gly Gly Val Arg Ala Val Ala Val Asp 
        355                 360                 365             


Ser Thr Gly Thr Tyr Met Ala Thr Ser Gly Leu Asp His Gln Leu Lys 
    370                 375                 380                 


Ile Phe Asp Leu Arg Gly Thr Tyr Gln Pro Leu Ser Thr Arg Thr Leu 
385                 390                 395                 400 


Pro His Gly Ala Gly His Leu Ala Phe Ser Gln Arg Gly Leu Leu Val 
                405                 410                 415     


Ala Gly Met Gly Asp Val Val Asn Ile Trp Ala Gly Gln Gly Lys Ala 
            420                 425                 430         


Ser Pro Pro Ser Leu Glu Gln Pro Tyr Leu Thr His Arg Leu Ser Gly 
        435                 440                 445             


Pro Val His Gly Leu Gln Phe Cys Pro Phe Glu Asp Val Leu Gly Val 
    450                 455                 460                 


Gly His Thr Gly Gly Ile Thr Ser Met Leu Val Pro Gly Ala Gly Glu 
465                 470                 475                 480 


Pro Asn Phe Asp Gly Leu Glu Ser Asn Pro Tyr Arg Ser Arg Lys Gln 
                485                 490                 495     


Arg Gln Glu Trp Glu Val Lys Ala Leu Leu Glu Lys Val Pro Ala Glu 
            500                 505                 510         


Leu Ile Cys Leu Asp Pro Arg Ala Leu Ala Glu Val Asp Val Ile Ser 
        515                 520                 525             


Leu Glu Gln Gly Lys Lys Glu Gln Ile Glu Arg Leu Gly Tyr Asp Pro 
    530                 535                 540                 


Gln Ala Lys Ala Pro Phe Gln Pro Lys Pro Lys Gln Lys Gly Arg Ser 
545                 550                 555                 560 


Ser Thr Ala Ser Leu Val Lys Arg Lys Arg Lys Val Met Asp Glu Glu 
                565                 570                 575     


His Arg Asp Lys Val Arg Gln Ser Leu Gln Gln Gln His His Lys Glu 
            580                 585                 590         


Ala Lys Ala Lys Pro Thr Gly Ala Arg Pro Ser Ala Leu Asp Arg Phe 
        595                 600                 605             


Val Arg 
    610 


<210>  47
<211>  710
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P19338
<309>  1993-04-24
<313>  (1)..(710)

<400>  47

Met Val Lys Leu Ala Lys Ala Gly Lys Asn Gln Gly Asp Pro Lys Lys 
1               5                   10                  15      


Met Ala Pro Pro Pro Lys Glu Val Glu Glu Asp Ser Glu Asp Glu Glu 
            20                  25                  30          


Met Ser Glu Asp Glu Glu Asp Asp Ser Ser Gly Glu Glu Val Val Ile 
        35                  40                  45              


Pro Gln Lys Lys Gly Lys Lys Ala Ala Ala Thr Ser Ala Lys Lys Val 
    50                  55                  60                  


Val Val Ser Pro Thr Lys Lys Val Ala Val Ala Thr Pro Ala Lys Lys 
65                  70                  75                  80  


Ala Ala Val Thr Pro Gly Lys Lys Ala Ala Ala Thr Pro Ala Lys Lys 
                85                  90                  95      


Thr Val Thr Pro Ala Lys Ala Val Thr Thr Pro Gly Lys Lys Gly Ala 
            100                 105                 110         


Thr Pro Gly Lys Ala Leu Val Ala Thr Pro Gly Lys Lys Gly Ala Ala 
        115                 120                 125             


Ile Pro Ala Lys Gly Ala Lys Asn Gly Lys Asn Ala Lys Lys Glu Asp 
    130                 135                 140                 


Ser Asp Glu Glu Glu Asp Asp Asp Ser Glu Glu Asp Glu Glu Asp Asp 
145                 150                 155                 160 


Glu Asp Glu Asp Glu Asp Glu Asp Glu Ile Glu Pro Ala Ala Met Lys 
                165                 170                 175     


Ala Ala Ala Ala Ala Pro Ala Ser Glu Asp Glu Asp Asp Glu Asp Asp 
            180                 185                 190         


Glu Asp Asp Glu Asp Asp Asp Asp Asp Glu Glu Asp Asp Ser Glu Glu 
        195                 200                 205             


Glu Ala Met Glu Thr Thr Pro Ala Lys Gly Lys Lys Ala Ala Lys Val 
    210                 215                 220                 


Val Pro Val Lys Ala Lys Asn Val Ala Glu Asp Glu Asp Glu Glu Glu 
225                 230                 235                 240 


Asp Asp Glu Asp Glu Asp Asp Asp Asp Asp Glu Asp Asp Glu Asp Asp 
                245                 250                 255     


Asp Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Pro 
            260                 265                 270         


Val Lys Glu Ala Pro Gly Lys Arg Lys Lys Glu Met Ala Lys Gln Lys 
        275                 280                 285             


Ala Ala Pro Glu Ala Lys Lys Gln Lys Val Glu Gly Thr Glu Pro Thr 
    290                 295                 300                 


Thr Ala Phe Asn Leu Phe Val Gly Asn Leu Asn Phe Asn Lys Ser Ala 
305                 310                 315                 320 


Pro Glu Leu Lys Thr Gly Ile Ser Asp Val Phe Ala Lys Asn Asp Leu 
                325                 330                 335     


Ala Val Val Asp Val Arg Ile Gly Met Thr Arg Lys Phe Gly Tyr Val 
            340                 345                 350         


Asp Phe Glu Ser Ala Glu Asp Leu Glu Lys Ala Leu Glu Leu Thr Gly 
        355                 360                 365             


Leu Lys Val Phe Gly Asn Glu Ile Lys Leu Glu Lys Pro Lys Gly Lys 
    370                 375                 380                 


Asp Ser Lys Lys Glu Arg Asp Ala Arg Thr Leu Leu Ala Lys Asn Leu 
385                 390                 395                 400 


Pro Tyr Lys Val Thr Gln Asp Glu Leu Lys Glu Val Phe Glu Asp Ala 
                405                 410                 415     


Ala Glu Ile Arg Leu Val Ser Lys Asp Gly Lys Ser Lys Gly Ile Ala 
            420                 425                 430         


Tyr Ile Glu Phe Lys Thr Glu Ala Asp Ala Glu Lys Thr Phe Glu Glu 
        435                 440                 445             


Lys Gln Gly Thr Glu Ile Asp Gly Arg Ser Ile Ser Leu Tyr Tyr Thr 
    450                 455                 460                 


Gly Glu Lys Gly Gln Asn Gln Asp Tyr Arg Gly Gly Lys Asn Ser Thr 
465                 470                 475                 480 


Trp Ser Gly Glu Ser Lys Thr Leu Val Leu Ser Asn Leu Ser Tyr Ser 
                485                 490                 495     


Ala Thr Glu Glu Thr Leu Gln Glu Val Phe Glu Lys Ala Thr Phe Ile 
            500                 505                 510         


Lys Val Pro Gln Asn Gln Asn Gly Lys Ser Lys Gly Tyr Ala Phe Ile 
        515                 520                 525             


Glu Phe Ala Ser Phe Glu Asp Ala Lys Glu Ala Leu Asn Ser Cys Asn 
    530                 535                 540                 


Lys Arg Glu Ile Glu Gly Arg Ala Ile Arg Leu Glu Leu Gln Gly Pro 
545                 550                 555                 560 


Arg Gly Ser Pro Asn Ala Arg Ser Gln Pro Ser Lys Thr Leu Phe Val 
                565                 570                 575     


Lys Gly Leu Ser Glu Asp Thr Thr Glu Glu Thr Leu Lys Glu Ser Phe 
            580                 585                 590         


Asp Gly Ser Val Arg Ala Arg Ile Val Thr Asp Arg Glu Thr Gly Ser 
        595                 600                 605             


Ser Lys Gly Phe Gly Phe Val Asp Phe Asn Ser Glu Glu Asp Ala Lys 
    610                 615                 620                 


Ala Ala Lys Glu Ala Met Glu Asp Gly Glu Ile Asp Gly Asn Lys Val 
625                 630                 635                 640 


Thr Leu Asp Trp Ala Lys Pro Lys Gly Glu Gly Gly Phe Gly Gly Arg 
                645                 650                 655     


Gly Gly Gly Arg Gly Gly Phe Gly Gly Arg Gly Gly Gly Arg Gly Gly 
            660                 665                 670         


Arg Gly Gly Phe Gly Gly Arg Gly Arg Gly Gly Phe Gly Gly Arg Gly 
        675                 680                 685             


Gly Phe Arg Gly Gly Arg Gly Gly Gly Gly Asp His Lys Pro Gln Gly 
    690                 695                 700                 


Lys Lys Thr Lys Phe Glu 
705                 710 


<210>  48
<211>  802
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q5VWQ0
<309>  2016-09-07
<313>  (1)..(802)

<400>  48

Met Phe Ile Ser Gly Arg Arg Thr Ala Asp Lys Trp Arg Ala Glu Glu 
1               5                   10                  15      


Arg Leu Gln Cys Pro Ala Gly Ser Ala Arg Ala Ala Leu Ala Arg Cys 
            20                  25                  30          


Ala Asp Gly Gly Ala Val Gly Pro Phe Lys Cys Val Phe Val Gly Glu 
        35                  40                  45              


Met Ala Ala Gln Val Gly Ala Val Arg Val Val Arg Ala Val Ala Ala 
    50                  55                  60                  


Gln Glu Glu Pro Asp Lys Glu Gly Lys Glu Lys Pro His Ala Gly Val 
65                  70                  75                  80  


Ser Pro Arg Gly Val Lys Arg Gln Arg Arg Ser Ser Ser Gly Gly Ser 
                85                  90                  95      


Gln Glu Lys Arg Gly Arg Pro Ser Gln Glu Pro Pro Leu Ala Pro Pro 
            100                 105                 110         


His Arg Arg Arg Arg Ser Arg Gln His Pro Gly Pro Leu Pro Pro Thr 
        115                 120                 125             


Asn Ala Ala Pro Thr Val Pro Gly Pro Val Glu Pro Leu Leu Leu Pro 
    130                 135                 140                 


Pro Pro Pro Pro Pro Ser Leu Ala Pro Ala Gly Pro Ala Val Ala Ala 
145                 150                 155                 160 


Pro Leu Pro Ala Pro Ser Thr Ser Ala Leu Phe Thr Phe Ser Pro Leu 
                165                 170                 175     


Thr Val Ser Ala Ala Gly Pro Lys His Lys Gly His Lys Glu Arg His 
            180                 185                 190         


Lys His His His His Arg Gly Pro Asp Gly Asp Pro Ser Ser Cys Gly 
        195                 200                 205             


Thr Asp Leu Lys His Lys Asp Lys Gln Glu Asn Gly Glu Arg Thr Gly 
    210                 215                 220                 


Gly Val Pro Leu Ile Lys Ala Pro Lys Arg Glu Thr Pro Asp Glu Asn 
225                 230                 235                 240 


Gly Lys Thr Gln Arg Ala Asp Asp Phe Val Leu Lys Lys Ile Lys Lys 
                245                 250                 255     


Lys Lys Lys Lys Lys His Arg Glu Asp Met Arg Gly Arg Arg Leu Lys 
            260                 265                 270         


Met Tyr Asn Lys Glu Val Gln Thr Val Cys Ala Gly Leu Thr Arg Ile 
        275                 280                 285             


Ser Lys Glu Ile Leu Thr Gln Gly Gln Ile Asn Ser Thr Ser Gly Leu 
    290                 295                 300                 


Asn Lys Glu Ser Phe Arg Tyr Leu Lys Asp Glu Gln Leu Cys Arg Leu 
305                 310                 315                 320 


Asn Leu Gly Met Gln Glu Tyr Arg Val Pro Gln Gly Val Gln Thr Pro 
                325                 330                 335     


Phe Met Thr His Gln Glu His Ser Ile Arg Arg Asn Phe Leu Lys Thr 
            340                 345                 350         


Gly Thr Lys Phe Ser Asn Phe Ile His Glu Glu His Gln Ser Asn Gly 
        355                 360                 365             


Gly Ala Leu Val Leu His Ala Tyr Met Asp Glu Leu Ser Phe Leu Ser 
    370                 375                 380                 


Pro Met Glu Met Glu Arg Phe Ser Glu Glu Phe Leu Ala Leu Thr Phe 
385                 390                 395                 400 


Ser Glu Asn Glu Lys Asn Ala Ala Tyr Tyr Ala Leu Ala Ile Val His 
                405                 410                 415     


Gly Ala Ala Ala Tyr Leu Pro Asp Phe Leu Asp Tyr Phe Ala Phe Asn 
            420                 425                 430         


Phe Pro Asn Thr Pro Val Lys Met Glu Ile Leu Gly Lys Lys Asp Ile 
        435                 440                 445             


Glu Thr Thr Thr Ile Ser Asn Phe His Thr Gln Val Asn Arg Thr Tyr 
    450                 455                 460                 


Cys Cys Gly Thr Tyr Arg Ala Gly Pro Met Arg Gln Ile Ser Leu Val 
465                 470                 475                 480 


Gly Ala Val Asp Glu Glu Val Gly Asp Tyr Phe Pro Glu Phe Leu Asp 
                485                 490                 495     


Met Leu Glu Glu Ser Pro Phe Leu Lys Met Thr Leu Pro Trp Gly Thr 
            500                 505                 510         


Leu Ser Ser Leu Arg Leu Gln Cys Arg Ser Gln Ser Asp Asp Gly Pro 
        515                 520                 525             


Ile Met Trp Val Arg Pro Gly Glu Gln Met Ile Pro Thr Ala Asp Met 
    530                 535                 540                 


Pro Lys Ser Pro Phe Lys Arg Arg Arg Ser Met Asn Glu Ile Lys Asn 
545                 550                 555                 560 


Leu Gln Tyr Leu Pro Arg Thr Ser Glu Pro Arg Glu Val Leu Phe Glu 
                565                 570                 575     


Asp Arg Thr Arg Ala His Ala Asp His Val Gly Gln Gly Phe Asp Trp 
            580                 585                 590         


Gln Ser Thr Ala Ala Val Gly Val Leu Lys Ala Val Gln Phe Gly Glu 
        595                 600                 605             


Trp Ser Asp Gln Pro Arg Ile Thr Lys Asp Val Ile Cys Phe His Ala 
    610                 615                 620                 


Glu Asp Phe Thr Asp Val Val Gln Arg Leu Gln Leu Asp Leu His Glu 
625                 630                 635                 640 


Pro Pro Val Ser Gln Cys Val Gln Trp Val Asp Glu Ala Lys Leu Asn 
                645                 650                 655     


Gln Met Arg Arg Glu Gly Ile Arg Tyr Ala Arg Ile Gln Leu Cys Asp 
            660                 665                 670         


Asn Asp Ile Tyr Phe Ile Pro Arg Asn Val Ile His Gln Phe Lys Thr 
        675                 680                 685             


Val Ser Ala Val Cys Ser Leu Ala Trp His Ile Arg Leu Lys Gln Tyr 
    690                 695                 700                 


His Pro Val Val Glu Ala Thr Gln Asn Thr Glu Ser Asn Ser Asn Met 
705                 710                 715                 720 


Asp Cys Gly Leu Thr Gly Lys Arg Glu Leu Glu Val Asp Ser Gln Cys 
                725                 730                 735     


Val Arg Ile Lys Thr Glu Ser Glu Glu Ala Cys Thr Glu Ile Gln Leu 
            740                 745                 750         


Leu Thr Thr Ala Ser Ser Ser Phe Pro Pro Ala Ser Glu Leu Asn Leu 
        755                 760                 765             


Gln Gln Asp Gln Lys Thr Gln Pro Ile Pro Val Leu Lys Val Glu Ser 
    770                 775                 780                 


Arg Leu Asp Ser Asp Gln Gln His Asn Leu Gln Glu His Ser Thr Thr 
785                 790                 795                 800 


Ser Val 
        


<210>  49
<211>  245
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P63104
<309>  2016-09-07
<313>  (1)..(245)

<400>  49

Met Asp Lys Asn Glu Leu Val Gln Lys Ala Lys Leu Ala Glu Gln Ala 
1               5                   10                  15      


Glu Arg Tyr Asp Asp Met Ala Ala Cys Met Lys Ser Val Thr Glu Gln 
            20                  25                  30          


Gly Ala Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val Ala Tyr 
        35                  40                  45              


Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Val Ser Ser 
    50                  55                  60                  


Ile Glu Gln Lys Thr Glu Gly Ala Glu Lys Lys Gln Gln Met Ala Arg 
65                  70                  75                  80  


Glu Tyr Arg Glu Lys Ile Glu Thr Glu Leu Arg Asp Ile Cys Asn Asp 
                85                  90                  95      


Val Leu Ser Leu Leu Glu Lys Phe Leu Ile Pro Asn Ala Ser Gln Ala 
            100                 105                 110         


Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Tyr Arg Tyr 
        115                 120                 125             


Leu Ala Glu Val Ala Ala Gly Asp Asp Lys Lys Gly Ile Val Asp Gln 
    130                 135                 140                 


Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys Glu Met 
145                 150                 155                 160 


Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe Ser Val 
                165                 170                 175     


Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser Leu Ala 
            180                 185                 190         


Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu Ser Glu 
        195                 200                 205             


Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg Asp Asn 
    210                 215                 220                 


Leu Thr Leu Trp Thr Ser Asp Thr Gln Gly Asp Glu Ala Glu Ala Gly 
225                 230                 235                 240 


Glu Gly Gly Glu Asn 
                245 


<210>  50
<211>  472
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P55317
<309>  2016-09-07
<313>  (1)..(472)

<400>  50

Met Leu Gly Thr Val Lys Met Glu Gly His Glu Thr Ser Asp Trp Asn 
1               5                   10                  15      


Ser Tyr Tyr Ala Asp Thr Gln Glu Ala Tyr Ser Ser Val Pro Val Ser 
            20                  25                  30          


Asn Met Asn Ser Gly Leu Gly Ser Met Asn Ser Met Asn Thr Tyr Met 
        35                  40                  45              


Thr Met Asn Thr Met Thr Thr Ser Gly Asn Met Thr Pro Ala Ser Phe 
    50                  55                  60                  


Asn Met Ser Tyr Ala Asn Pro Gly Leu Gly Ala Gly Leu Ser Pro Gly 
65                  70                  75                  80  


Ala Val Ala Gly Met Pro Gly Gly Ser Ala Gly Ala Met Asn Ser Met 
                85                  90                  95      


Thr Ala Ala Gly Val Thr Ala Met Gly Thr Ala Leu Ser Pro Ser Gly 
            100                 105                 110         


Met Gly Ala Met Gly Ala Gln Gln Ala Ala Ser Met Asn Gly Leu Gly 
        115                 120                 125             


Pro Tyr Ala Ala Ala Met Asn Pro Cys Met Ser Pro Met Ala Tyr Ala 
    130                 135                 140                 


Pro Ser Asn Leu Gly Arg Ser Arg Ala Gly Gly Gly Gly Asp Ala Lys 
145                 150                 155                 160 


Thr Phe Lys Arg Ser Tyr Pro His Ala Lys Pro Pro Tyr Ser Tyr Ile 
                165                 170                 175     


Ser Leu Ile Thr Met Ala Ile Gln Gln Ala Pro Ser Lys Met Leu Thr 
            180                 185                 190         


Leu Ser Glu Ile Tyr Gln Trp Ile Met Asp Leu Phe Pro Tyr Tyr Arg 
        195                 200                 205             


Gln Asn Gln Gln Arg Trp Gln Asn Ser Ile Arg His Ser Leu Ser Phe 
    210                 215                 220                 


Asn Asp Cys Phe Val Lys Val Ala Arg Ser Pro Asp Lys Pro Gly Lys 
225                 230                 235                 240 


Gly Ser Tyr Trp Thr Leu His Pro Asp Ser Gly Asn Met Phe Glu Asn 
                245                 250                 255     


Gly Cys Tyr Leu Arg Arg Gln Lys Arg Phe Lys Cys Glu Lys Gln Pro 
            260                 265                 270         


Gly Ala Gly Gly Gly Gly Gly Ser Gly Ser Gly Gly Ser Gly Ala Lys 
        275                 280                 285             


Gly Gly Pro Glu Ser Arg Lys Asp Pro Ser Gly Ala Ser Asn Pro Ser 
    290                 295                 300                 


Ala Asp Ser Pro Leu His Arg Gly Val His Gly Lys Thr Gly Gln Leu 
305                 310                 315                 320 


Glu Gly Ala Pro Ala Pro Gly Pro Ala Ala Ser Pro Gln Thr Leu Asp 
                325                 330                 335     


His Ser Gly Ala Thr Ala Thr Gly Gly Ala Ser Glu Leu Lys Thr Pro 
            340                 345                 350         


Ala Ser Ser Thr Ala Pro Pro Ile Ser Ser Gly Pro Gly Ala Leu Ala 
        355                 360                 365             


Ser Val Pro Ala Ser His Pro Ala His Gly Leu Ala Pro His Glu Ser 
    370                 375                 380                 


Gln Leu His Leu Lys Gly Asp Pro His Tyr Ser Phe Asn His Pro Phe 
385                 390                 395                 400 


Ser Ile Asn Asn Leu Met Ser Ser Ser Glu Gln Gln His Lys Leu Asp 
                405                 410                 415     


Phe Lys Ala Tyr Glu Gln Ala Leu Gln Tyr Ser Pro Tyr Gly Ser Thr 
            420                 425                 430         


Leu Pro Ala Ser Leu Pro Leu Gly Ser Ala Ser Val Thr Thr Arg Ser 
        435                 440                 445             


Pro Ile Glu Pro Ser Ala Leu Glu Pro Ala Tyr Tyr Gln Gly Val Tyr 
    450                 455                 460                 


Ser Arg Pro Val Leu Asn Thr Ser 
465                 470         


<210>  51
<211>  376
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q562R1
<309>  2016-09-07
<313>  (1)..(376)

<400>  51

Met Thr Asp Asn Glu Leu Ser Ala Leu Val Val Asp Asn Gly Ser Gly 
1               5                   10                  15      


Met Cys Lys Ala Gly Phe Gly Gly Asp Asp Ala Pro Arg Ala Val Phe 
            20                  25                  30          


Pro Ser Met Ile Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met 
        35                  40                  45              


Gly Gln Lys Asp Cys Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly 
    50                  55                  60                  


Val Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Val Val Thr Asn Trp 
65                  70                  75                  80  


Asp Asp Met Glu Lys Ile Trp Tyr His Thr Phe Tyr Asn Glu Leu Arg 
                85                  90                  95      


Val Ala Pro Asp Glu His Pro Ile Leu Leu Thr Glu Ala Pro Leu Asn 
            100                 105                 110         


Pro Lys Ile Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Ala Phe 
        115                 120                 125             


Asn Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr 
    130                 135                 140                 


Ala Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val 
145                 150                 155                 160 


Thr His Ile Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile 
                165                 170                 175     


Leu Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys 
            180                 185                 190         


Ile Leu Thr Glu Arg Gly Tyr Asn Phe Thr Thr Thr Ala Glu Arg Glu 
        195                 200                 205             


Ile Val Arg Asp Val Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe 
    210                 215                 220                 


Glu Gln Glu Met Val Arg Ala Ala Ala Ser Ser Ser Pro Glu Arg Ser 
225                 230                 235                 240 


Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe 
                245                 250                 255     


Arg Cys Pro Glu Ala Ile Phe Gln Pro Ser Phe Leu Gly Ile Glu Ser 
            260                 265                 270         


Ser Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val 
        275                 280                 285             


Asp Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Ser 
    290                 295                 300                 


Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Ile Thr 
305                 310                 315                 320 


Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg 
                325                 330                 335     


Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr 
            340                 345                 350         


Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly Pro 
        355                 360                 365             


Pro Ile Val His Arg Lys Cys Phe 
    370                 375     


<210>  52
<211>  355
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q14106
<309>  2016-09-07
<313>  (1)..(355)

<400>  52

Met Ser Glu Glu Gln Phe Gly Gly Asp Gly Ala Ala Ala Ala Ala Thr 
1               5                   10                  15      


Ala Ala Val Gly Gly Ser Ala Gly Glu Gln Glu Gly Ala Met Val Ala 
            20                  25                  30          


Ala Thr Gln Gly Ala Ala Ala Ala Ala Gly Ser Gly Ala Gly Thr Gly 
        35                  40                  45              


Gly Gly Thr Ala Ser Gly Gly Thr Glu Gly Gly Ser Ala Glu Ser Glu 
    50                  55                  60                  


Gly Ala Lys Ile Asp Ala Ser Lys Asn Glu Glu Asp Glu Gly His Ser 
65                  70                  75                  80  


Asn Ser Ser Pro Arg His Ser Glu Ala Ala Thr Ala Gln Arg Glu Glu 
                85                  90                  95      


Trp Lys Met Phe Ile Gly Gly Leu Ser Trp Asp Thr Thr Lys Lys Asp 
            100                 105                 110         


Leu Lys Asp Tyr Phe Ser Lys Phe Gly Glu Val Val Asp Cys Thr Leu 
        115                 120                 125             


Lys Leu Asp Pro Ile Thr Gly Arg Ser Arg Gly Phe Gly Phe Val Leu 
    130                 135                 140                 


Phe Lys Glu Ser Glu Ser Val Asp Lys Val Met Asp Gln Lys Glu His 
145                 150                 155                 160 


Lys Leu Asn Gly Lys Val Ile Asp Pro Lys Arg Ala Lys Ala Met Lys 
                165                 170                 175     


Thr Lys Glu Pro Val Lys Lys Ile Phe Val Gly Gly Leu Ser Pro Asp 
            180                 185                 190         


Thr Pro Glu Glu Lys Ile Arg Glu Tyr Phe Gly Gly Phe Gly Glu Val 
        195                 200                 205             


Glu Ser Ile Glu Leu Pro Met Asp Asn Lys Thr Asn Lys Arg Arg Gly 
    210                 215                 220                 


Phe Cys Phe Ile Thr Phe Lys Glu Glu Glu Pro Val Lys Lys Ile Met 
225                 230                 235                 240 


Glu Lys Lys Tyr His Asn Val Gly Leu Ser Lys Cys Glu Ile Lys Val 
                245                 250                 255     


Ala Met Ser Lys Glu Gln Tyr Gln Gln Gln Gln Gln Trp Gly Ser Arg 
            260                 265                 270         


Gly Gly Phe Ala Gly Arg Ala Arg Gly Arg Gly Gly Gly Pro Ser Gln 
        275                 280                 285             


Asn Trp Asn Gln Gly Tyr Ser Asn Tyr Trp Asn Gln Gly Tyr Gly Asn 
    290                 295                 300                 


Tyr Gly Tyr Asn Ser Gln Gly Tyr Gly Gly Tyr Gly Gly Tyr Asp Tyr 
305                 310                 315                 320 


Thr Gly Tyr Asn Asn Tyr Tyr Gly Tyr Gly Asp Tyr Ser Asn Gln Gln 
                325                 330                 335     


Ser Gly Tyr Gly Lys Val Ser Arg Arg Gly Gly His Gln Asn Ser Tyr 
            340                 345                 350         


Lys Pro Tyr 
        355 


<210>  53
<211>  378
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P51991
<309>  2016-09-07
<313>  (1)..(378)

<400>  53

Met Glu Val Lys Pro Pro Pro Gly Arg Pro Gln Pro Asp Ser Gly Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Gly Glu Glu Gly His Asp Pro Lys Glu Pro Glu 
            20                  25                  30          


Gln Leu Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr Thr Asp 
        35                  40                  45              


Asp Ser Leu Arg Glu His Phe Glu Lys Trp Gly Thr Leu Thr Asp Cys 
    50                  55                  60                  


Val Val Met Arg Asp Pro Gln Thr Lys Arg Ser Arg Gly Phe Gly Phe 
65                  70                  75                  80  


Val Thr Tyr Ser Cys Val Glu Glu Val Asp Ala Ala Met Cys Ala Arg 
                85                  90                  95      


Pro His Lys Val Asp Gly Arg Val Val Glu Pro Lys Arg Ala Val Ser 
            100                 105                 110         


Arg Glu Asp Ser Val Lys Pro Gly Ala His Leu Thr Val Lys Lys Ile 
        115                 120                 125             


Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu Tyr Asn Leu Arg Asp 
    130                 135                 140                 


Tyr Phe Glu Lys Tyr Gly Lys Ile Glu Thr Ile Glu Val Met Glu Asp 
145                 150                 155                 160 


Arg Gln Ser Gly Lys Lys Arg Gly Phe Ala Phe Val Thr Phe Asp Asp 
                165                 170                 175     


His Asp Thr Val Asp Lys Ile Val Val Gln Lys Tyr His Thr Ile Asn 
            180                 185                 190         


Gly His Asn Cys Glu Val Lys Lys Ala Leu Ser Lys Gln Glu Met Gln 
        195                 200                 205             


Ser Ala Gly Ser Gln Arg Gly Arg Gly Gly Gly Ser Gly Asn Phe Met 
    210                 215                 220                 


Gly Arg Gly Gly Asn Phe Gly Gly Gly Gly Gly Asn Phe Gly Arg Gly 
225                 230                 235                 240 


Gly Asn Phe Gly Gly Arg Gly Gly Tyr Gly Gly Gly Gly Gly Gly Ser 
                245                 250                 255     


Arg Gly Ser Tyr Gly Gly Gly Asp Gly Gly Tyr Asn Gly Phe Gly Gly 
            260                 265                 270         


Asp Gly Gly Asn Tyr Gly Gly Gly Pro Gly Tyr Ser Ser Arg Gly Gly 
        275                 280                 285             


Tyr Gly Gly Gly Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly 
    290                 295                 300                 


Gly Gly Gly Gly Tyr Asp Gly Tyr Asn Glu Gly Gly Asn Phe Gly Gly 
305                 310                 315                 320 


Gly Asn Tyr Gly Gly Gly Gly Asn Tyr Asn Asp Phe Gly Asn Tyr Ser 
                325                 330                 335     


Gly Gln Gln Gln Ser Asn Tyr Gly Pro Met Lys Gly Gly Ser Phe Gly 
            340                 345                 350         


Gly Arg Ser Ser Gly Ser Pro Tyr Gly Gly Gly Tyr Gly Ser Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Tyr Gly Ser Arg Arg Phe 
    370                 375             


<210>  54
<211>  159
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P47914
<309>  2016-09-07
<313>  (1)..(159)

<400>  54

Met Ala Lys Ser Lys Asn His Thr Thr His Asn Gln Ser Arg Lys Trp 
1               5                   10                  15      


His Arg Asn Gly Ile Lys Lys Pro Arg Ser Gln Arg Tyr Glu Ser Leu 
            20                  25                  30          


Lys Gly Val Asp Pro Lys Phe Leu Arg Asn Met Arg Phe Ala Lys Lys 
        35                  40                  45              


His Asn Lys Lys Gly Leu Lys Lys Met Gln Ala Asn Asn Ala Lys Ala 
    50                  55                  60                  


Met Ser Ala Arg Ala Glu Ala Ile Lys Ala Leu Val Lys Pro Lys Glu 
65                  70                  75                  80  


Val Lys Pro Lys Ile Pro Lys Gly Val Ser Arg Lys Leu Asp Arg Leu 
                85                  90                  95      


Ala Tyr Ile Ala His Pro Lys Leu Gly Lys Arg Ala Arg Ala Arg Ile 
            100                 105                 110         


Ala Lys Gly Leu Arg Leu Cys Arg Pro Lys Ala Lys Ala Lys Ala Lys 
        115                 120                 125             


Ala Lys Asp Gln Thr Lys Ala Gln Ala Ala Ala Pro Ala Ser Val Pro 
    130                 135                 140                 


Ala Gln Ala Pro Lys Arg Thr Gln Ala Pro Thr Lys Ala Ser Glu 
145                 150                 155                 


<210>  55
<211>  953
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q86VM9
<309>  2016-09-07
<313>  (1)..(953)

<400>  55

Met Asp Val Ala Glu Ser Pro Glu Arg Asp Pro His Ser Pro Glu Asp 
1               5                   10                  15      


Glu Glu Gln Pro Gln Gly Leu Ser Asp Asp Asp Ile Leu Arg Asp Ser 
            20                  25                  30          


Gly Ser Asp Gln Asp Leu Asp Gly Ala Gly Val Arg Ala Ser Asp Leu 
        35                  40                  45              


Glu Asp Glu Glu Ser Ala Ala Arg Gly Pro Ser Gln Glu Glu Glu Asp 
    50                  55                  60                  


Asn His Ser Asp Glu Glu Asp Arg Ala Ser Glu Pro Lys Ser Gln Asp 
65                  70                  75                  80  


Gln Asp Ser Glu Val Asn Glu Leu Ser Arg Gly Pro Thr Ser Ser Pro 
                85                  90                  95      


Cys Glu Glu Glu Gly Asp Glu Gly Glu Glu Asp Arg Thr Ser Asp Leu 
            100                 105                 110         


Arg Asp Glu Ala Ser Ser Val Thr Arg Glu Leu Asp Glu His Glu Leu 
        115                 120                 125             


Asp Tyr Asp Glu Glu Val Pro Glu Glu Pro Ala Pro Ala Val Gln Glu 
    130                 135                 140                 


Asp Glu Ala Glu Lys Ala Gly Ala Glu Asp Asp Glu Glu Lys Gly Glu 
145                 150                 155                 160 


Gly Thr Pro Arg Glu Glu Gly Lys Ala Gly Val Gln Ser Val Gly Glu 
                165                 170                 175     


Lys Glu Ser Leu Glu Ala Ala Lys Glu Lys Lys Lys Glu Asp Asp Asp 
            180                 185                 190         


Gly Glu Ile Asp Asp Gly Glu Ile Asp Asp Asp Asp Leu Glu Glu Gly 
        195                 200                 205             


Glu Val Lys Asp Pro Ser Asp Arg Lys Val Arg Pro Arg Pro Thr Cys 
    210                 215                 220                 


Arg Phe Phe Met Lys Gly Asn Cys Thr Trp Gly Met Asn Cys Arg Phe 
225                 230                 235                 240 


Ile His Pro Gly Val Asn Asp Lys Gly Asn Tyr Ser Leu Ile Thr Lys 
                245                 250                 255     


Ala Asp Pro Phe Pro Pro Asn Gly Ala Pro Pro Leu Gly Pro His Pro 
            260                 265                 270         


Leu Met Pro Ala Asn Pro Trp Gly Gly Pro Val Val Asp Glu Ile Leu 
        275                 280                 285             


Pro Pro Pro Pro Pro Glu Pro Pro Thr Glu Ser Ala Trp Glu Arg Gly 
    290                 295                 300                 


Leu Arg His Ala Lys Glu Val Leu Lys Lys Ala Thr Ile Arg Lys Glu 
305                 310                 315                 320 


Gln Glu Pro Asp Phe Glu Glu Lys Arg Phe Thr Val Thr Ile Gly Glu 
                325                 330                 335     


Asp Glu Arg Glu Phe Asp Lys Glu Asn Glu Val Phe Arg Asp Trp Asn 
            340                 345                 350         


Ser Arg Ile Pro Arg Asp Val Arg Asp Thr Val Leu Glu Pro Tyr Ala 
        355                 360                 365             


Asp Pro Tyr Tyr Asp Tyr Glu Ile Glu Arg Phe Trp Arg Gly Gly Gln 
    370                 375                 380                 


Tyr Glu Asn Phe Arg Val Gln Tyr Thr Glu Thr Glu Pro Tyr His Asn 
385                 390                 395                 400 


Tyr Arg Glu Arg Glu Arg Glu Arg Glu Arg Glu Asn Arg Gln Arg Glu 
                405                 410                 415     


Arg Glu Arg Glu Arg Glu Arg Asp Arg Glu Arg Glu Arg Arg Gln Arg 
            420                 425                 430         


Glu Arg Glu Arg Glu Arg Glu Arg Glu Arg Asp Lys Glu Arg Gln Arg 
        435                 440                 445             


Arg Lys Glu Glu Trp Glu Arg Glu Arg Ala Lys Arg Asp Glu Lys Asp 
    450                 455                 460                 


Arg Gln His Arg Asp Arg Asp Arg Glu Lys Glu Arg Glu Lys Glu Lys 
465                 470                 475                 480 


Gly Lys Pro Lys Pro Arg Ser Pro Gln Pro Pro Ser Arg Gln Ala Glu 
                485                 490                 495     


Pro Pro Lys Lys Glu Ala Ala Thr Thr Gly Pro Gln Val Lys Arg Ala 
            500                 505                 510         


Asp Glu Trp Lys Asp Pro Trp Arg Arg Ser Lys Ser Pro Lys Lys Lys 
        515                 520                 525             


Leu Gly Val Ser Val Ser Pro Ser Arg Ala Arg Arg Arg Arg Lys Thr 
    530                 535                 540                 


Ser Ala Ser Ser Ala Ser Ala Ser Asn Ser Ser Arg Ser Ser Ser Arg 
545                 550                 555                 560 


Ser Ser Ser Tyr Ser Gly Ser Gly Ser Ser Arg Ser Arg Ser Arg Ser 
                565                 570                 575     


Ser Ser Tyr Ser Ser Tyr Ser Ser Arg Ser Ser Arg His Ser Ser Phe 
            580                 585                 590         


Ser Gly Ser Arg Ser Arg Ser Arg Ser Phe Ser Ser Ser Pro Ser Pro 
        595                 600                 605             


Ser Pro Thr Pro Ser Pro His Arg Pro Ser Ile Arg Thr Lys Gly Glu 
    610                 615                 620                 


Pro Ala Pro Pro Pro Gly Lys Ala Gly Glu Lys Ser Val Lys Lys Pro 
625                 630                 635                 640 


Ala Pro Pro Pro Ala Pro Pro Gln Ala Thr Lys Thr Thr Ala Pro Val 
                645                 650                 655     


Pro Glu Pro Thr Lys Pro Gly Asp Pro Arg Glu Ala Arg Arg Lys Glu 
            660                 665                 670         


Arg Pro Ala Arg Thr Pro Pro Arg Arg Arg Thr Leu Ser Gly Ser Gly 
        675                 680                 685             


Ser Gly Ser Gly Ser Ser Tyr Ser Gly Ser Ser Ser Arg Ser Arg Ser 
    690                 695                 700                 


Leu Ser Val Ser Ser Val Ser Ser Val Ser Ser Ala Thr Ser Ser Ser 
705                 710                 715                 720 


Ser Ser Ala His Ser Val Asp Ser Glu Asp Met Tyr Ala Asp Leu Ala 
                725                 730                 735     


Ser Pro Val Ser Ser Ala Ser Ser Arg Ser Pro Ala Pro Ala Gln Thr 
            740                 745                 750         


Arg Lys Glu Lys Gly Lys Ser Lys Lys Glu Asp Gly Val Lys Glu Glu 
        755                 760                 765             


Lys Arg Lys Arg Asp Ser Ser Thr Gln Pro Pro Lys Ser Ala Lys Pro 
    770                 775                 780                 


Pro Ala Gly Gly Lys Ser Ser Gln Gln Pro Ser Thr Pro Gln Gln Ala 
785                 790                 795                 800 


Pro Pro Gly Gln Pro Gln Gln Gly Thr Phe Val Ala His Lys Glu Ile 
                805                 810                 815     


Lys Leu Thr Leu Leu Asn Lys Ala Ala Asp Lys Gly Ser Arg Lys Arg 
            820                 825                 830         


Tyr Glu Pro Ser Asp Lys Asp Arg Gln Ser Pro Pro Pro Ala Lys Arg 
        835                 840                 845             


Pro Asn Thr Ser Pro Asp Arg Gly Ser Arg Asp Arg Lys Ser Gly Gly 
    850                 855                 860                 


Arg Leu Gly Ser Pro Lys Pro Glu Arg Gln Arg Gly Gln Asn Ser Lys 
865                 870                 875                 880 


Ala Pro Ala Ala Pro Ala Asp Arg Lys Arg Gln Leu Ser Pro Gln Ser 
                885                 890                 895     


Lys Ser Ser Ser Lys Val Thr Ser Val Pro Gly Lys Ala Ser Asp Pro 
            900                 905                 910         


Gly Ala Ala Ser Thr Lys Ser Gly Lys Ala Ser Thr Leu Ser Arg Arg 
        915                 920                 925             


Glu Glu Leu Leu Lys Gln Leu Lys Ala Val Glu Asp Ala Ile Ala Arg 
    930                 935                 940                 


Lys Arg Ala Lys Ile Pro Gly Lys Ala 
945                 950             


<210>  56
<211>  285
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9ULR0
<309>  2016-09-07
<313>  (1)..(285)

<400>  56

Met Ala Arg Asn Ala Glu Lys Ala Met Thr Ala Leu Ala Arg Phe Arg 
1               5                   10                  15      


Gln Ala Gln Leu Glu Glu Gly Lys Val Lys Glu Arg Arg Pro Phe Leu 
            20                  25                  30          


Ala Ser Glu Cys Thr Glu Leu Pro Lys Ala Glu Lys Trp Arg Arg Gln 
        35                  40                  45              


Ile Ile Gly Glu Ile Ser Lys Lys Val Ala Gln Ile Gln Asn Ala Gly 
    50                  55                  60                  


Leu Gly Glu Phe Arg Ile Arg Asp Leu Asn Asp Glu Ile Asn Lys Leu 
65                  70                  75                  80  


Leu Arg Glu Lys Gly His Trp Glu Val Arg Ile Lys Glu Leu Gly Gly 
                85                  90                  95      


Pro Asp Tyr Gly Lys Val Gly Pro Lys Met Leu Asp His Glu Gly Lys 
            100                 105                 110         


Glu Val Pro Gly Asn Arg Gly Tyr Lys Tyr Phe Gly Ala Ala Lys Asp 
        115                 120                 125             


Leu Pro Gly Val Arg Glu Leu Phe Glu Lys Glu Pro Leu Pro Pro Pro 
    130                 135                 140                 


Arg Lys Thr Arg Ala Glu Leu Met Lys Ala Ile Asp Phe Glu Tyr Tyr 
145                 150                 155                 160 


Gly Tyr Leu Asp Glu Asp Asp Gly Val Ile Val Pro Leu Glu Gln Glu 
                165                 170                 175     


Tyr Glu Lys Lys Leu Arg Ala Glu Leu Val Glu Lys Trp Lys Ala Glu 
            180                 185                 190         


Arg Glu Ala Arg Leu Ala Arg Gly Glu Lys Glu Glu Glu Glu Glu Glu 
        195                 200                 205             


Glu Glu Glu Ile Asn Ile Tyr Ala Val Thr Glu Glu Glu Ser Asp Glu 
    210                 215                 220                 


Glu Gly Ser Gln Glu Lys Gly Gly Asp Asp Ser Gln Gln Lys Phe Ile 
225                 230                 235                 240 


Ala His Val Pro Val Pro Ser Gln Gln Glu Ile Glu Glu Ala Leu Val 
                245                 250                 255     


Arg Arg Lys Lys Met Glu Leu Leu Gln Lys Tyr Ala Ser Glu Thr Leu 
            260                 265                 270         


Gln Ala Gln Ser Glu Glu Ala Arg Arg Leu Leu Gly Tyr 
        275                 280                 285 


<210>  57
<211>  463
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P61978
<309>  2016-09-07
<313>  (1)..(463)

<400>  57

Met Glu Thr Glu Gln Pro Glu Glu Thr Phe Pro Asn Thr Glu Thr Asn 
1               5                   10                  15      


Gly Glu Phe Gly Lys Arg Pro Ala Glu Asp Met Glu Glu Glu Gln Ala 
            20                  25                  30          


Phe Lys Arg Ser Arg Asn Thr Asp Glu Met Val Glu Leu Arg Ile Leu 
        35                  40                  45              


Leu Gln Ser Lys Asn Ala Gly Ala Val Ile Gly Lys Gly Gly Lys Asn 
    50                  55                  60                  


Ile Lys Ala Leu Arg Thr Asp Tyr Asn Ala Ser Val Ser Val Pro Asp 
65                  70                  75                  80  


Ser Ser Gly Pro Glu Arg Ile Leu Ser Ile Ser Ala Asp Ile Glu Thr 
                85                  90                  95      


Ile Gly Glu Ile Leu Lys Lys Ile Ile Pro Thr Leu Glu Glu Gly Leu 
            100                 105                 110         


Gln Leu Pro Ser Pro Thr Ala Thr Ser Gln Leu Pro Leu Glu Ser Asp 
        115                 120                 125             


Ala Val Glu Cys Leu Asn Tyr Gln His Tyr Lys Gly Ser Asp Phe Asp 
    130                 135                 140                 


Cys Glu Leu Arg Leu Leu Ile His Gln Ser Leu Ala Gly Gly Ile Ile 
145                 150                 155                 160 


Gly Val Lys Gly Ala Lys Ile Lys Glu Leu Arg Glu Asn Thr Gln Thr 
                165                 170                 175     


Thr Ile Lys Leu Phe Gln Glu Cys Cys Pro His Ser Thr Asp Arg Val 
            180                 185                 190         


Val Leu Ile Gly Gly Lys Pro Asp Arg Val Val Glu Cys Ile Lys Ile 
        195                 200                 205             


Ile Leu Asp Leu Ile Ser Glu Ser Pro Ile Lys Gly Arg Ala Gln Pro 
    210                 215                 220                 


Tyr Asp Pro Asn Phe Tyr Asp Glu Thr Tyr Asp Tyr Gly Gly Phe Thr 
225                 230                 235                 240 


Met Met Phe Asp Asp Arg Arg Gly Arg Pro Val Gly Phe Pro Met Arg 
                245                 250                 255     


Gly Arg Gly Gly Phe Asp Arg Met Pro Pro Gly Arg Gly Gly Arg Pro 
            260                 265                 270         


Met Pro Pro Ser Arg Arg Asp Tyr Asp Asp Met Ser Pro Arg Arg Gly 
        275                 280                 285             


Pro Pro Pro Pro Pro Pro Gly Arg Gly Gly Arg Gly Gly Ser Arg Ala 
    290                 295                 300                 


Arg Asn Leu Pro Leu Pro Pro Pro Pro Pro Pro Arg Gly Gly Asp Leu 
305                 310                 315                 320 


Met Ala Tyr Asp Arg Arg Gly Arg Pro Gly Asp Arg Tyr Asp Gly Met 
                325                 330                 335     


Val Gly Phe Ser Ala Asp Glu Thr Trp Asp Ser Ala Ile Asp Thr Trp 
            340                 345                 350         


Ser Pro Ser Glu Trp Gln Met Ala Tyr Glu Pro Gln Gly Gly Ser Gly 
        355                 360                 365             


Tyr Asp Tyr Ser Tyr Ala Gly Gly Arg Gly Ser Tyr Gly Asp Leu Gly 
    370                 375                 380                 


Gly Pro Ile Ile Thr Thr Gln Val Thr Ile Pro Lys Asp Leu Ala Gly 
385                 390                 395                 400 


Ser Ile Ile Gly Lys Gly Gly Gln Arg Ile Lys Gln Ile Arg His Glu 
                405                 410                 415     


Ser Gly Ala Ser Ile Lys Ile Asp Glu Pro Leu Glu Gly Ser Glu Asp 
            420                 425                 430         


Arg Ile Ile Thr Ile Thr Gly Thr Gln Asp Gln Ile Gln Asn Ala Gln 
        435                 440                 445             


Tyr Leu Leu Gln Asn Ser Val Lys Gln Tyr Ser Gly Lys Phe Phe 
    450                 455                 460             


<210>  58
<211>  215
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O75396
<309>  2004-04-16
<313>  (1)..(215)

<400>  58

Met Val Leu Leu Thr Met Ile Ala Arg Val Ala Asp Gly Leu Pro Leu 
1               5                   10                  15      


Ala Ala Ser Met Gln Glu Asp Glu Gln Ser Gly Arg Asp Leu Gln Gln 
            20                  25                  30          


Tyr Gln Ser Gln Ala Lys Gln Leu Phe Arg Lys Leu Asn Glu Gln Ser 
        35                  40                  45              


Pro Thr Arg Cys Thr Leu Glu Ala Gly Ala Met Thr Phe His Tyr Ile 
    50                  55                  60                  


Ile Glu Gln Gly Val Cys Asp Leu Val Leu Cys Glu Ala Ala Phe Pro 
65                  70                  75                  80  


Lys Thr Leu Ala Phe Ala Tyr Leu Glu Asp Leu His Ser Glu Phe Asp 
                85                  90                  95      


Glu Gln His Gly Lys Lys Val Pro Thr Val Ser Arg Pro Tyr Ser Phe 
            100                 105                 110         


Ile Glu Phe Asp Thr Phe Ile Gln Lys Thr Lys Lys Leu Tyr Ile Asp 
        115                 120                 125             


Ser Cys Ala Arg Arg Asn Leu Gly Ser Ile Asn Thr Glu Leu Gln Asp 
    130                 135                 140                 


Val Gln Arg Ile Met Val Ala Asn Ile Glu Glu Val Leu Gln Arg Gly 
145                 150                 155                 160 


Glu Ala Leu Ser Ala Leu Asp Ser Lys Ala Asn Asn Leu Ser Ser Leu 
                165                 170                 175     


Ser Lys Lys Tyr Arg Gln Asp Ala Lys Tyr Leu Asn Met His Ser Thr 
            180                 185                 190         


Tyr Ala Lys Leu Ala Ala Val Ala Val Phe Phe Ile Met Leu Ile Val 
        195                 200                 205             


Tyr Val Arg Phe Trp Trp Leu 
    210                 215 


<210>  59
<211>  353
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P22626
<309>  1993-04-24
<313>  (1)..(353)

<400>  59

Met Glu Lys Thr Leu Glu Thr Val Pro Leu Glu Arg Lys Lys Arg Glu 
1               5                   10                  15      


Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr 
            20                  25                  30          


Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln Trp Gly Lys Leu Thr 
        35                  40                  45              


Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg Ser Arg Gly Phe 
    50                  55                  60                  


Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp Ala Ala Met Ala 
65                  70                  75                  80  


Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu Pro Lys Arg Ala 
                85                  90                  95      


Val Ala Arg Glu Glu Ser Gly Lys Pro Gly Ala His Val Thr Val Lys 
            100                 105                 110         


Lys Leu Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu 
        115                 120                 125             


Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile 
    130                 135                 140                 


Thr Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Gly Phe Val Thr Phe 
145                 150                 155                 160 


Asp Asp His Asp Pro Val Asp Lys Ile Val Leu Gln Lys Tyr His Thr 
                165                 170                 175     


Ile Asn Gly His Asn Ala Glu Val Arg Lys Ala Leu Ser Arg Gln Glu 
            180                 185                 190         


Met Gln Glu Val Gln Ser Ser Arg Ser Gly Arg Gly Gly Asn Phe Gly 
        195                 200                 205             


Phe Gly Asp Ser Arg Gly Gly Gly Gly Asn Phe Gly Pro Gly Pro Gly 
    210                 215                 220                 


Ser Asn Phe Arg Gly Gly Ser Asp Gly Tyr Gly Ser Gly Arg Gly Phe 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Tyr Gly Gly Gly Pro Gly Gly Gly Asn Phe 
                245                 250                 255     


Gly Gly Ser Pro Gly Tyr Gly Gly Gly Arg Gly Gly Tyr Gly Gly Gly 
            260                 265                 270         


Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly Tyr Asp 
        275                 280                 285             


Asn Tyr Gly Gly Gly Asn Tyr Gly Ser Gly Asn Tyr Asn Asp Phe Gly 
    290                 295                 300                 


Asn Tyr Asn Gln Gln Pro Ser Asn Tyr Gly Pro Met Lys Ser Gly Asn 
305                 310                 315                 320 


Phe Gly Gly Ser Arg Asn Met Gly Gly Pro Tyr Gly Gly Gly Asn Tyr 
                325                 330                 335     


Gly Pro Gly Gly Ser Gly Gly Ser Gly Gly Tyr Gly Gly Arg Ser Arg 
            340                 345                 350         


Tyr 
    


<210>  60
<211>  644
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q14166
<309>  2016-09-07
<313>  (1)..(644)

<400>  60

Met Glu Ala Glu Arg Gly Pro Glu Arg Arg Pro Ala Glu Arg Ser Ser 
1               5                   10                  15      


Pro Gly Gln Thr Pro Glu Glu Gly Ala Gln Ala Leu Ala Glu Phe Ala 
            20                  25                  30          


Ala Leu His Gly Pro Ala Leu Arg Ala Ser Gly Val Pro Glu Arg Tyr 
        35                  40                  45              


Trp Gly Arg Leu Leu His Lys Leu Glu His Glu Val Phe Asp Ala Gly 
    50                  55                  60                  


Glu Val Phe Gly Ile Met Gln Val Glu Glu Val Glu Glu Glu Glu Asp 
65                  70                  75                  80  


Glu Ala Ala Arg Glu Val Arg Lys Gln Gln Pro Asn Pro Gly Asn Glu 
                85                  90                  95      


Leu Cys Tyr Lys Val Ile Val Thr Arg Glu Ser Gly Leu Gln Ala Ala 
            100                 105                 110         


His Pro Asn Ser Ile Phe Leu Ile Asp His Ala Trp Thr Cys Arg Val 
        115                 120                 125             


Glu His Ala Arg Gln Gln Leu Gln Gln Val Pro Gly Leu Leu His Arg 
    130                 135                 140                 


Met Ala Asn Leu Met Gly Ile Glu Phe His Gly Glu Leu Pro Ser Thr 
145                 150                 155                 160 


Glu Ala Val Ala Leu Val Leu Glu Glu Met Trp Lys Phe Asn Gln Thr 
                165                 170                 175     


Tyr Gln Leu Ala His Gly Thr Ala Glu Glu Lys Met Pro Val Trp Tyr 
            180                 185                 190         


Ile Met Asp Glu Phe Gly Ser Arg Ile Gln His Ala Asp Val Pro Ser 
        195                 200                 205             


Phe Ala Thr Ala Pro Phe Phe Tyr Met Pro Gln Gln Val Ala Tyr Thr 
    210                 215                 220                 


Leu Leu Trp Pro Leu Arg Asp Leu Asp Thr Gly Glu Glu Val Thr Arg 
225                 230                 235                 240 


Asp Phe Ala Tyr Gly Glu Thr Asp Pro Leu Ile Arg Lys Cys Met Leu 
                245                 250                 255     


Leu Pro Trp Ala Pro Thr Asp Met Leu Asp Leu Ser Ser Cys Thr Pro 
            260                 265                 270         


Glu Pro Pro Ala Glu His Tyr Gln Ala Ile Leu Glu Glu Asn Lys Glu 
        275                 280                 285             


Lys Leu Pro Leu Asp Ile Asn Pro Val Val His Pro His Gly His Ile 
    290                 295                 300                 


Phe Lys Val Tyr Thr Asp Val Gln Gln Val Ala Ser Ser Leu Thr His 
305                 310                 315                 320 


Pro Arg Phe Thr Leu Thr Gln Ser Glu Ala Asp Ala Asp Ile Leu Phe 
                325                 330                 335     


Asn Phe Ser His Phe Lys Asp Tyr Arg Lys Leu Ser Gln Glu Arg Pro 
            340                 345                 350         


Gly Val Leu Leu Asn Gln Phe Pro Cys Glu Asn Leu Leu Thr Val Lys 
        355                 360                 365             


Asp Cys Leu Ala Ser Ile Ala Arg Arg Ala Gly Gly Pro Glu Gly Pro 
    370                 375                 380                 


Pro Trp Leu Pro Arg Thr Phe Asn Leu Arg Thr Glu Leu Pro Gln Phe 
385                 390                 395                 400 


Val Ser Tyr Phe Gln Gln Arg Glu Arg Trp Gly Glu Asp Asn His Trp 
                405                 410                 415     


Ile Cys Lys Pro Trp Asn Leu Ala Arg Ser Leu Asp Thr His Val Thr 
            420                 425                 430         


Lys Ser Leu His Ser Ile Ile Arg His Arg Glu Ser Thr Pro Lys Val 
        435                 440                 445             


Val Ser Lys Tyr Ile Glu Ser Pro Val Leu Phe Leu Arg Glu Asp Val 
    450                 455                 460                 


Gly Lys Val Lys Phe Asp Ile Arg Tyr Ile Val Leu Leu Arg Ser Val 
465                 470                 475                 480 


Arg Pro Leu Arg Leu Phe Val Tyr Asp Val Phe Trp Leu Arg Phe Ser 
                485                 490                 495     


Asn Arg Ala Phe Ala Leu Asn Asp Leu Asp Asp Tyr Glu Lys His Phe 
            500                 505                 510         


Thr Val Met Asn Tyr Asp Pro Asp Val Val Leu Lys Gln Val His Cys 
        515                 520                 525             


Glu Glu Phe Ile Pro Glu Phe Glu Lys Gln Tyr Pro Glu Phe Pro Trp 
    530                 535                 540                 


Thr Asp Val Gln Ala Glu Ile Phe Arg Ala Phe Thr Glu Leu Phe Gln 
545                 550                 555                 560 


Val Ala Cys Ala Lys Pro Pro Pro Leu Gly Leu Cys Asp Tyr Pro Ser 
                565                 570                 575     


Ser Arg Ala Met Tyr Ala Val Asp Leu Met Leu Lys Trp Asp Asn Gly 
            580                 585                 590         


Pro Asp Gly Arg Arg Val Met Gln Pro Gln Ile Leu Glu Val Asn Phe 
        595                 600                 605             


Asn Pro Asp Cys Glu Arg Ala Cys Arg Tyr His Pro Thr Phe Phe Asn 
    610                 615                 620                 


Asp Val Phe Ser Thr Leu Phe Leu Asp Gln Pro Gly Gly Cys His Val 
625                 630                 635                 640 


Thr Cys Leu Val 
                


<210>  61
<211>  356
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q15365
<309>  2016-09-07
<313>  (1)..(356)

<400>  61

Met Asp Ala Gly Val Thr Glu Ser Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Arg Ile Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Thr Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Asn Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Thr Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Val Pro Gln Ser Val Thr Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Leu Val Met Leu Glu Thr Leu Ser Gln Ser Pro Gln Gly 
                165                 170                 175     


Arg Val Met Thr Ile Pro Tyr Gln Pro Met Pro Ala Ser Ser Pro Val 
            180                 185                 190         


Ile Cys Ala Gly Gly Gln Asp Arg Cys Ser Asp Ala Ala Gly Tyr Pro 
        195                 200                 205             


His Ala Thr His Asp Leu Glu Gly Pro Pro Leu Asp Ala Tyr Ser Ile 
    210                 215                 220                 


Gln Gly Gln His Thr Ile Ser Pro Leu Asp Leu Ala Lys Leu Asn Gln 
225                 230                 235                 240 


Val Ala Arg Gln Gln Ser His Phe Ala Met Met His Gly Gly Thr Gly 
                245                 250                 255     


Phe Ala Gly Ile Asp Ser Ser Ser Pro Glu Val Lys Gly Tyr Trp Ala 
            260                 265                 270         


Ser Leu Asp Ala Ser Thr Gln Thr Thr His Glu Leu Thr Ile Pro Asn 
        275                 280                 285             


Asn Leu Ile Gly Cys Ile Ile Gly Arg Gln Gly Ala Asn Ile Asn Glu 
    290                 295                 300                 


Ile Arg Gln Met Ser Gly Ala Gln Ile Lys Ile Ala Asn Pro Val Glu 
305                 310                 315                 320 


Gly Ser Ser Gly Arg Gln Val Thr Ile Thr Gly Ser Ala Ala Ser Ile 
                325                 330                 335     


Ser Leu Ala Gln Tyr Leu Ile Asn Ala Arg Leu Ser Ser Glu Lys Gly 
            340                 345                 350         


Met Gly Cys Ser 
        355     


<210>  62
<211>  305
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q13151
<309>  2016-09-07
<313>  (1)..(305)

<400>  62

Met Glu Asn Ser Gln Leu Cys Lys Leu Phe Ile Gly Gly Leu Asn Val 
1               5                   10                  15      


Gln Thr Ser Glu Ser Gly Leu Arg Gly His Phe Glu Ala Phe Gly Thr 
            20                  25                  30          


Leu Thr Asp Cys Val Val Val Val Asn Pro Gln Thr Lys Arg Ser Arg 
        35                  40                  45              


Cys Phe Gly Phe Val Thr Tyr Ser Asn Val Glu Glu Ala Asp Ala Ala 
    50                  55                  60                  


Met Ala Ala Ser Pro His Ala Val Asp Gly Asn Thr Val Glu Leu Lys 
65                  70                  75                  80  


Arg Ala Val Ser Arg Glu Asp Ser Ala Arg Pro Gly Ala His Ala Lys 
                85                  90                  95      


Val Lys Lys Leu Phe Val Gly Gly Leu Lys Gly Asp Val Ala Glu Gly 
            100                 105                 110         


Asp Leu Ile Glu His Phe Ser Gln Phe Gly Thr Val Glu Lys Ala Glu 
        115                 120                 125             


Ile Ile Ala Asp Lys Gln Ser Gly Lys Lys Arg Gly Phe Gly Phe Val 
    130                 135                 140                 


Tyr Phe Gln Asn His Asp Ala Ala Asp Lys Ala Ala Val Val Lys Phe 
145                 150                 155                 160 


His Pro Ile Gln Gly His Arg Val Glu Val Lys Lys Ala Val Pro Lys 
                165                 170                 175     


Glu Asp Ile Tyr Ser Gly Gly Gly Gly Gly Gly Ser Arg Ser Ser Arg 
            180                 185                 190         


Gly Gly Arg Gly Gly Arg Gly Arg Gly Gly Gly Arg Asp Gln Asn Gly 
        195                 200                 205             


Leu Ser Lys Gly Gly Gly Gly Gly Tyr Asn Ser Tyr Gly Gly Tyr Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Tyr Asn Ala Tyr Gly Gly Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Ser Tyr Gly Gly Ser Asp Tyr Gly Asn Gly Phe Gly Gly Phe Gly 
                245                 250                 255     


Ser Tyr Ser Gln His Gln Ser Ser Tyr Gly Pro Met Lys Ser Gly Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Ser Ser Trp Gly Gly Arg Ser Asn Ser Gly 
        275                 280                 285             


Pro Tyr Arg Gly Gly Tyr Gly Gly Gly Gly Gly Tyr Gly Gly Ser Ser 
    290                 295                 300                 


Phe 
305 


<210>  63
<211>  157
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P98179
<309>  2016-09-07
<313>  (1)..(157)

<400>  63

Met Ser Ser Glu Glu Gly Lys Leu Phe Val Gly Gly Leu Asn Phe Asn 
1               5                   10                  15      


Thr Asp Glu Gln Ala Leu Glu Asp His Phe Ser Ser Phe Gly Pro Ile 
            20                  25                  30          


Ser Glu Val Val Val Val Lys Asp Arg Glu Thr Gln Arg Ser Arg Gly 
        35                  40                  45              


Phe Gly Phe Ile Thr Phe Thr Asn Pro Glu His Ala Ser Val Ala Met 
    50                  55                  60                  


Arg Ala Met Asn Gly Glu Ser Leu Asp Gly Arg Gln Ile Arg Val Asp 
65                  70                  75                  80  


His Ala Gly Lys Ser Ala Arg Gly Thr Arg Gly Gly Gly Phe Gly Ala 
                85                  90                  95      


His Gly Arg Gly Arg Ser Tyr Ser Arg Gly Gly Gly Asp Gln Gly Tyr 
            100                 105                 110         


Gly Ser Gly Arg Tyr Tyr Asp Ser Arg Pro Gly Gly Tyr Gly Tyr Gly 
        115                 120                 125             


Tyr Gly Arg Ser Arg Asp Tyr Asn Gly Arg Asn Gln Gly Gly Tyr Asp 
    130                 135                 140                 


Arg Tyr Ser Gly Gly Asn Tyr Arg Asp Asn Tyr Asp Asn 
145                 150                 155         


<210>  64
<211>  293
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O60812
<309>  2002-05-06
<313>  (1)..(293)

<400>  64

Met Ala Ser Asn Val Thr Asn Lys Met Asp Pro His Ser Met Asn Ser 
1               5                   10                  15      


Arg Val Phe Ile Gly Asn Leu Asn Thr Leu Val Val Lys Lys Ser Asp 
            20                  25                  30          


Val Glu Ala Ile Phe Ser Lys Tyr Gly Lys Ile Ala Gly Cys Ser Val 
        35                  40                  45              


His Lys Gly Phe Ala Phe Val Gln Tyr Asp Lys Glu Lys Asn Ala Arg 
    50                  55                  60                  


Ala Ala Val Ala Gly Glu Asp Gly Arg Met Ile Ala Ser Gln Val Val 
65                  70                  75                  80  


Asp Ile Asn Leu Ala Ala Glu Pro Lys Val Asn Arg Gly Asn Ala Gly 
                85                  90                  95      


Val Lys Arg Ser Ala Ala Glu Met Tyr Gly Ser Ser Phe Asp Leu Asp 
            100                 105                 110         


Tyr Gly Phe Gln Arg Asp Tyr Tyr Asp Gly Met Tyr Ser Phe Pro Ala 
        115                 120                 125             


Arg Val Pro Pro Pro Pro Pro Ile Ala Leu Ala Val Val Pro Ser Lys 
    130                 135                 140                 


Arg Gln Arg Leu Ser Gly Asn Thr Ser Arg Arg Gly Lys Ser Gly Phe 
145                 150                 155                 160 


Asn Ser Lys Ser Gly Lys Arg Gly Ser Ser Lys Ser Gly Lys Leu Lys 
                165                 170                 175     


Gly Asp Asp Leu Gln Ala Ile Lys Gln Glu Leu Thr Gln Ile Lys Gln 
            180                 185                 190         


Lys Val Asp Ser Leu Leu Glu Asn Leu Glu Lys Ile Glu Lys Glu Gln 
        195                 200                 205             


Ser Lys Gln Glu Val Glu Val Lys Asn Ala Lys Ser Glu Glu Glu Gln 
    210                 215                 220                 


Ser Ser Ser Ser Met Lys Lys Asp Glu Thr His Val Lys Met Glu Ser 
225                 230                 235                 240 


Glu Gly Gly Ala Glu Asp Ser Ala Glu Glu Gly Asp Pro Leu Asp Asp 
                245                 250                 255     


Asp Val Asn Glu Asp Gln Gly Asp Asp Gln Leu Glu Leu Ile Lys Asp 
            260                 265                 270         


Asp Glu Lys Glu Ala Glu Glu Gly Glu Asp Asp Arg Asp Ser Thr Asn 
        275                 280                 285             


Gly Gln Asp Asp Ser 
    290             


<210>  65
<211>  530
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q14498
<309>  2016-09-07
<313>  (1)..(530)

<400>  65

Met Ala Asp Asp Ile Asp Ile Glu Ala Met Leu Glu Ala Pro Tyr Lys 
1               5                   10                  15      


Lys Asp Glu Asn Lys Leu Ser Ser Ala Asn Gly His Glu Glu Arg Ser 
            20                  25                  30          


Lys Lys Arg Lys Lys Ser Lys Ser Arg Ser Arg Ser His Glu Arg Lys 
        35                  40                  45              


Arg Ser Lys Ser Lys Glu Arg Lys Arg Ser Arg Asp Arg Glu Arg Lys 
    50                  55                  60                  


Lys Ser Lys Ser Arg Glu Arg Lys Arg Ser Arg Ser Lys Glu Arg Arg 
65                  70                  75                  80  


Arg Ser Arg Ser Arg Ser Arg Asp Arg Arg Phe Arg Gly Arg Tyr Arg 
                85                  90                  95      


Ser Pro Tyr Ser Gly Pro Lys Phe Asn Ser Ala Ile Arg Gly Lys Ile 
            100                 105                 110         


Gly Leu Pro His Ser Ile Lys Leu Ser Arg Arg Arg Ser Arg Ser Lys 
        115                 120                 125             


Ser Pro Phe Arg Lys Asp Lys Ser Pro Val Arg Glu Pro Ile Asp Asn 
    130                 135                 140                 


Leu Thr Pro Glu Glu Arg Asp Ala Arg Thr Val Phe Cys Met Gln Leu 
145                 150                 155                 160 


Ala Ala Arg Ile Arg Pro Arg Asp Leu Glu Glu Phe Phe Ser Thr Val 
                165                 170                 175     


Gly Lys Val Arg Asp Val Arg Met Ile Ser Asp Arg Asn Ser Arg Arg 
            180                 185                 190         


Ser Lys Gly Ile Ala Tyr Val Glu Phe Val Asp Val Ser Ser Val Pro 
        195                 200                 205             


Leu Ala Ile Gly Leu Thr Gly Gln Arg Val Leu Gly Val Pro Ile Ile 
    210                 215                 220                 


Val Gln Ala Ser Gln Ala Glu Lys Asn Arg Ala Ala Ala Met Ala Asn 
225                 230                 235                 240 


Asn Leu Gln Lys Gly Ser Ala Gly Pro Met Arg Leu Tyr Val Gly Ser 
                245                 250                 255     


Leu His Phe Asn Ile Thr Glu Asp Met Leu Arg Gly Ile Phe Glu Pro 
            260                 265                 270         


Phe Gly Arg Ile Glu Ser Ile Gln Leu Met Met Asp Ser Glu Thr Gly 
        275                 280                 285             


Arg Ser Lys Gly Tyr Gly Phe Ile Thr Phe Ser Asp Ser Glu Cys Ala 
    290                 295                 300                 


Lys Lys Ala Leu Glu Gln Leu Asn Gly Phe Glu Leu Ala Gly Arg Pro 
305                 310                 315                 320 


Met Lys Val Gly His Val Thr Glu Arg Thr Asp Ala Ser Ser Ala Ser 
                325                 330                 335     


Ser Phe Leu Asp Ser Asp Glu Leu Glu Arg Thr Gly Ile Asp Leu Gly 
            340                 345                 350         


Thr Thr Gly Arg Leu Gln Leu Met Ala Arg Leu Ala Glu Gly Thr Gly 
        355                 360                 365             


Leu Gln Ile Pro Pro Ala Ala Gln Gln Ala Leu Gln Met Ser Gly Ser 
    370                 375                 380                 


Leu Ala Phe Gly Ala Val Ala Glu Phe Ser Phe Val Ile Asp Leu Gln 
385                 390                 395                 400 


Thr Arg Leu Ser Gln Gln Thr Glu Ala Ser Ala Leu Ala Ala Ala Ala 
                405                 410                 415     


Ser Val Gln Pro Leu Ala Thr Gln Cys Phe Gln Leu Ser Asn Met Phe 
            420                 425                 430         


Asn Pro Gln Thr Glu Glu Glu Val Gly Trp Asp Thr Glu Ile Lys Asp 
        435                 440                 445             


Asp Val Ile Glu Glu Cys Asn Lys His Gly Gly Val Ile His Ile Tyr 
    450                 455                 460                 


Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val Lys Cys Pro Ser 
465                 470                 475                 480 


Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu His Gly Arg Trp Phe 
                485                 490                 495     


Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu Pro Thr Tyr His 
            500                 505                 510         


Asn Leu Phe Pro Asp Ser Met Thr Ala Thr Gln Leu Leu Val Pro Ser 
        515                 520                 525             


Arg Arg 
    530 


<210>  66
<211>  677
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P49848
<309>  2016-09-07
<313>  (1)..(677)

<400>  66

Met Ala Glu Glu Lys Lys Leu Lys Leu Ser Asn Thr Val Leu Pro Ser 
1               5                   10                  15      


Glu Ser Met Lys Val Val Ala Glu Ser Met Gly Ile Ala Gln Ile Gln 
            20                  25                  30          


Glu Glu Thr Cys Gln Leu Leu Thr Asp Glu Val Ser Tyr Arg Ile Lys 
        35                  40                  45              


Glu Ile Ala Gln Asp Ala Leu Lys Phe Met His Met Gly Lys Arg Gln 
    50                  55                  60                  


Lys Leu Thr Thr Ser Asp Ile Asp Tyr Ala Leu Lys Leu Lys Asn Val 
65                  70                  75                  80  


Glu Pro Leu Tyr Gly Phe His Ala Gln Glu Phe Ile Pro Phe Arg Phe 
                85                  90                  95      


Ala Ser Gly Gly Gly Arg Glu Leu Tyr Phe Tyr Glu Glu Lys Glu Val 
            100                 105                 110         


Asp Leu Ser Asp Ile Ile Asn Thr Pro Leu Pro Arg Val Pro Leu Asp 
        115                 120                 125             


Val Cys Leu Lys Ala His Trp Leu Ser Ile Glu Gly Cys Gln Pro Ala 
    130                 135                 140                 


Ile Pro Glu Asn Pro Pro Pro Ala Pro Lys Glu Gln Gln Lys Ala Glu 
145                 150                 155                 160 


Ala Thr Glu Pro Leu Lys Ser Ala Lys Pro Gly Gln Glu Glu Asp Gly 
                165                 170                 175     


Pro Leu Lys Gly Lys Gly Gln Gly Ala Thr Thr Ala Asp Gly Lys Gly 
            180                 185                 190         


Lys Glu Lys Lys Ala Pro Pro Leu Leu Glu Gly Ala Pro Leu Arg Leu 
        195                 200                 205             


Lys Pro Arg Ser Ile His Glu Leu Ser Val Glu Gln Gln Leu Tyr Tyr 
    210                 215                 220                 


Lys Glu Ile Thr Glu Ala Cys Val Gly Ser Cys Glu Ala Lys Arg Ala 
225                 230                 235                 240 


Glu Ala Leu Gln Ser Ile Ala Thr Asp Pro Gly Leu Tyr Gln Met Leu 
                245                 250                 255     


Pro Arg Phe Ser Thr Phe Ile Ser Glu Gly Val Arg Val Asn Val Val 
            260                 265                 270         


Gln Asn Asn Leu Ala Leu Leu Ile Tyr Leu Met Arg Met Val Lys Ala 
        275                 280                 285             


Leu Met Asp Asn Pro Thr Leu Tyr Leu Glu Lys Tyr Val His Glu Leu 
    290                 295                 300                 


Ile Pro Ala Val Met Thr Cys Ile Val Ser Arg Gln Leu Cys Leu Arg 
305                 310                 315                 320 


Pro Asp Val Asp Asn His Trp Ala Leu Arg Asp Phe Ala Ala Arg Leu 
                325                 330                 335     


Val Ala Gln Ile Cys Lys His Phe Ser Thr Thr Thr Asn Asn Ile Gln 
            340                 345                 350         


Ser Arg Ile Thr Lys Thr Phe Thr Lys Ser Trp Val Asp Glu Lys Thr 
        355                 360                 365             


Pro Trp Thr Thr Arg Tyr Gly Ser Ile Ala Gly Leu Ala Glu Leu Gly 
    370                 375                 380                 


His Asp Val Ile Lys Thr Leu Ile Leu Pro Arg Leu Gln Gln Glu Gly 
385                 390                 395                 400 


Glu Arg Ile Arg Ser Val Leu Asp Gly Pro Val Leu Ser Asn Ile Asp 
                405                 410                 415     


Arg Ile Gly Ala Asp His Val Gln Ser Leu Leu Leu Lys His Cys Ala 
            420                 425                 430         


Pro Val Leu Ala Lys Leu Arg Pro Pro Pro Asp Asn Gln Asp Ala Tyr 
        435                 440                 445             


Arg Ala Glu Phe Gly Ser Leu Gly Pro Leu Leu Cys Ser Gln Val Val 
    450                 455                 460                 


Lys Ala Arg Ala Gln Ala Ala Leu Gln Ala Gln Gln Val Asn Arg Thr 
465                 470                 475                 480 


Thr Leu Thr Ile Thr Gln Pro Arg Pro Thr Leu Thr Leu Ser Gln Ala 
                485                 490                 495     


Pro Gln Pro Gly Pro Arg Thr Pro Gly Leu Leu Lys Val Pro Gly Ser 
            500                 505                 510         


Ile Ala Leu Pro Val Gln Thr Leu Val Ser Ala Arg Ala Ala Ala Pro 
        515                 520                 525             


Pro Gln Pro Ser Pro Pro Pro Thr Lys Phe Ile Val Met Ser Ser Ser 
    530                 535                 540                 


Ser Ser Ala Pro Ser Thr Gln Gln Val Leu Ser Leu Ser Thr Ser Ala 
545                 550                 555                 560 


Pro Gly Ser Gly Ser Thr Thr Thr Ser Pro Val Thr Thr Thr Val Pro 
                565                 570                 575     


Ser Val Gln Pro Ile Val Lys Leu Val Ser Thr Ala Thr Thr Ala Pro 
            580                 585                 590         


Pro Ser Thr Ala Pro Ser Gly Pro Gly Ser Val Gln Lys Tyr Ile Val 
        595                 600                 605             


Val Ser Leu Pro Pro Thr Gly Glu Gly Lys Gly Gly Pro Thr Ser His 
    610                 615                 620                 


Pro Ser Pro Val Pro Pro Pro Ala Ser Ser Pro Ser Pro Leu Ser Gly 
625                 630                 635                 640 


Ser Ala Leu Cys Gly Gly Lys Gln Glu Ala Gly Asp Ser Pro Pro Pro 
                645                 650                 655     


Ala Pro Gly Thr Pro Lys Ala Asn Gly Ser Gln Pro Asn Ser Gly Ser 
            660                 665                 670         


Pro Gln Pro Ala Pro 
        675         


<210>  67
<211>  392
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9Y383
<309>  2016-09-07
<313>  (1)..(392)

<400>  67

Met Ser Ala Gln Ala Gln Met Arg Ala Met Leu Asp Gln Leu Met Gly 
1               5                   10                  15      


Thr Ser Arg Asp Gly Asp Thr Thr Arg Gln Arg Ile Lys Phe Ser Asp 
            20                  25                  30          


Asp Arg Val Cys Lys Ser His Leu Leu Asn Cys Cys Pro His Asp Val 
        35                  40                  45              


Leu Ser Gly Thr Arg Met Asp Leu Gly Glu Cys Leu Lys Val His Asp 
    50                  55                  60                  


Leu Ala Leu Arg Ala Asp Tyr Glu Ile Ala Ser Lys Glu Gln Asp Phe 
65                  70                  75                  80  


Phe Phe Glu Leu Asp Ala Met Asp His Leu Gln Ser Phe Ile Ala Asp 
                85                  90                  95      


Cys Asp Arg Arg Thr Glu Val Ala Lys Lys Arg Leu Ala Glu Thr Gln 
            100                 105                 110         


Glu Glu Ile Ser Ala Glu Val Ala Ala Lys Ala Glu Arg Val His Glu 
        115                 120                 125             


Leu Asn Glu Glu Ile Gly Lys Leu Leu Ala Lys Val Glu Gln Leu Gly 
    130                 135                 140                 


Ala Glu Gly Asn Val Glu Glu Ser Gln Lys Val Met Asp Glu Val Glu 
145                 150                 155                 160 


Lys Ala Arg Ala Lys Lys Arg Glu Ala Glu Glu Val Tyr Arg Asn Ser 
                165                 170                 175     


Met Pro Ala Ser Ser Phe Gln Gln Gln Lys Leu Arg Val Cys Glu Val 
            180                 185                 190         


Cys Ser Ala Tyr Leu Gly Leu His Asp Asn Asp Arg Arg Leu Ala Asp 
        195                 200                 205             


His Phe Gly Gly Lys Leu His Leu Gly Phe Ile Glu Ile Arg Glu Lys 
    210                 215                 220                 


Leu Glu Glu Leu Lys Arg Val Val Ala Glu Lys Gln Glu Lys Arg Asn 
225                 230                 235                 240 


Gln Glu Arg Leu Lys Arg Arg Glu Glu Arg Glu Arg Glu Glu Arg Glu 
                245                 250                 255     


Lys Leu Arg Arg Ser Arg Ser His Ser Lys Asn Pro Lys Arg Ser Arg 
            260                 265                 270         


Ser Arg Glu His Arg Arg His Arg Ser Arg Ser Met Ser Arg Glu Arg 
        275                 280                 285             


Lys Arg Arg Thr Arg Ser Lys Ser Arg Glu Lys Arg His Arg His Arg 
    290                 295                 300                 


Ser Arg Ser Ser Ser Arg Ser Arg Ser Arg Ser His Gln Arg Ser Arg 
305                 310                 315                 320 


His Ser Ser Arg Asp Arg Ser Arg Glu Arg Ser Lys Arg Arg Ser Ser 
                325                 330                 335     


Lys Glu Arg Phe Arg Asp Gln Asp Leu Ala Ser Cys Asp Arg Asp Arg 
            340                 345                 350         


Ser Ser Arg Asp Arg Ser Pro Arg Asp Arg Asp Arg Lys Asp Lys Lys 
        355                 360                 365             


Arg Ser Tyr Glu Ser Ala Asn Gly Arg Ser Glu Asp Arg Arg Ser Ser 
    370                 375                 380                 


Glu Glu Arg Glu Ala Gly Glu Ile 
385                 390         


<210>  68
<211>  3685
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P11532
<309>  1993-04-23
<313>  (1)..(3685)

<400>  68

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      


Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          


Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              


Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  


Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  


Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      


Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         


Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             


Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 


Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 


Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     


Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         


Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             


Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 


Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 


Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     


Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         


His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             


Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 


Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 


His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     


Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         


Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             


Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 


Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 


Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     


Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         


Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             


Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 


Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 


Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     


Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         


Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             


Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 


Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 


Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     


Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         


Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             


Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 


Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 


Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     


Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         


Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             


Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 


Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 
705                 710                 715                 720 


Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 
                725                 730                 735     


Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 
            740                 745                 750         


Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 
        755                 760                 765             


Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 
    770                 775                 780                 


Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 
785                 790                 795                 800 


Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 
                805                 810                 815     


Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 
            820                 825                 830         


Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 
        835                 840                 845             


Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 
    850                 855                 860                 


Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 
865                 870                 875                 880 


Ser Asp Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 
                885                 890                 895     


Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 
            900                 905                 910         


Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 
        915                 920                 925             


Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 
    930                 935                 940                 


Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 
945                 950                 955                 960 


Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 
                965                 970                 975     


Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 
            980                 985                 990         


Gln Ser Gly Leu Tyr Tyr Leu Ser  Thr Thr Val Lys Glu  Met Ser Lys 
        995                 1000                 1005             


Lys Ala  Pro Ser Glu Ile Ser  Arg Lys Tyr Gln Ser  Glu Phe Glu 
    1010                 1015                 1020             


Glu Ile  Glu Gly Arg Trp Lys  Lys Leu Ser Ser Gln  Leu Val Glu 
    1025                 1030                 1035             


His Cys  Gln Lys Leu Glu Glu  Gln Met Asn Lys Leu  Arg Lys Ile 
    1040                 1045                 1050             


Gln Asn  His Ile Gln Thr Leu  Lys Lys Trp Met Ala  Glu Val Asp 
    1055                 1060                 1065             


Val Phe  Leu Lys Glu Glu Trp  Pro Ala Leu Gly Asp  Ser Glu Ile 
    1070                 1075                 1080             


Leu Lys  Lys Gln Leu Lys Gln  Cys Arg Leu Leu Val  Ser Asp Ile 
    1085                 1090                 1095             


Gln Thr  Ile Gln Pro Ser Leu  Asn Ser Val Asn Glu  Gly Gly Gln 
    1100                 1105                 1110             


Lys Ile  Lys Asn Glu Ala Glu  Pro Glu Phe Ala Ser  Arg Leu Glu 
    1115                 1120                 1125             


Thr Glu  Leu Lys Glu Leu Asn  Thr Gln Trp Asp His  Met Cys Gln 
    1130                 1135                 1140             


Gln Val  Tyr Ala Arg Lys Glu  Ala Leu Lys Gly Gly  Leu Glu Lys 
    1145                 1150                 1155             


Thr Val  Ser Leu Gln Lys Asp  Leu Ser Glu Met His  Glu Trp Met 
    1160                 1165                 1170             


Thr Gln  Ala Glu Glu Glu Tyr  Leu Glu Arg Asp Phe  Glu Tyr Lys 
    1175                 1180                 1185             


Thr Pro  Asp Glu Leu Gln Lys  Ala Val Glu Glu Met  Lys Arg Ala 
    1190                 1195                 1200             


Lys Glu  Glu Ala Gln Gln Lys  Glu Ala Lys Val Lys  Leu Leu Thr 
    1205                 1210                 1215             


Glu Ser  Val Asn Ser Val Ile  Ala Gln Ala Pro Pro  Val Ala Gln 
    1220                 1225                 1230             


Glu Ala  Leu Lys Lys Glu Leu  Glu Thr Leu Thr Thr  Asn Tyr Gln 
    1235                 1240                 1245             


Trp Leu  Cys Thr Arg Leu Asn  Gly Lys Cys Lys Thr  Leu Glu Glu 
    1250                 1255                 1260             


Val Trp  Ala Cys Trp His Glu  Leu Leu Ser Tyr Leu  Glu Lys Ala 
    1265                 1270                 1275             


Asn Lys  Trp Leu Asn Glu Val  Glu Phe Lys Leu Lys  Thr Thr Glu 
    1280                 1285                 1290             


Asn Ile  Pro Gly Gly Ala Glu  Glu Ile Ser Glu Val  Leu Asp Ser 
    1295                 1300                 1305             


Leu Glu  Asn Leu Met Arg His  Ser Glu Asp Asn Pro  Asn Gln Ile 
    1310                 1315                 1320             


Arg Ile  Leu Ala Gln Thr Leu  Thr Asp Gly Gly Val  Met Asp Glu 
    1325                 1330                 1335             


Leu Ile  Asn Glu Glu Leu Glu  Thr Phe Asn Ser Arg  Trp Arg Glu 
    1340                 1345                 1350             


Leu His  Glu Glu Ala Val Arg  Arg Gln Lys Leu Leu  Glu Gln Ser 
    1355                 1360                 1365             


Ile Gln  Ser Ala Gln Glu Thr  Glu Lys Ser Leu His  Leu Ile Gln 
    1370                 1375                 1380             


Glu Ser  Leu Thr Phe Ile Asp  Lys Gln Leu Ala Ala  Tyr Ile Ala 
    1385                 1390                 1395             


Asp Lys  Val Asp Ala Ala Gln  Met Pro Gln Glu Ala  Gln Lys Ile 
    1400                 1405                 1410             


Gln Ser  Asp Leu Thr Ser His  Glu Ile Ser Leu Glu  Glu Met Lys 
    1415                 1420                 1425             


Lys His  Asn Gln Gly Lys Glu  Ala Ala Gln Arg Val  Leu Ser Gln 
    1430                 1435                 1440             


Ile Asp  Val Ala Gln Lys Lys  Leu Gln Asp Val Ser  Met Lys Phe 
    1445                 1450                 1455             


Arg Leu  Phe Gln Lys Pro Ala  Asn Phe Glu Gln Arg  Leu Gln Glu 
    1460                 1465                 1470             


Ser Lys  Met Ile Leu Asp Glu  Val Lys Met His Leu  Pro Ala Leu 
    1475                 1480                 1485             


Glu Thr  Lys Ser Val Glu Gln  Glu Val Val Gln Ser  Gln Leu Asn 
    1490                 1495                 1500             


His Cys  Val Asn Leu Tyr Lys  Ser Leu Ser Glu Val  Lys Ser Glu 
    1505                 1510                 1515             


Val Glu  Met Val Ile Lys Thr  Gly Arg Gln Ile Val  Gln Lys Lys 
    1520                 1525                 1530             


Gln Thr  Glu Asn Pro Lys Glu  Leu Asp Glu Arg Val  Thr Ala Leu 
    1535                 1540                 1545             


Lys Leu  His Tyr Asn Glu Leu  Gly Ala Lys Val Thr  Glu Arg Lys 
    1550                 1555                 1560             


Gln Gln  Leu Glu Lys Cys Leu  Lys Leu Ser Arg Lys  Met Arg Lys 
    1565                 1570                 1575             


Glu Met  Asn Val Leu Thr Glu  Trp Leu Ala Ala Thr  Asp Met Glu 
    1580                 1585                 1590             


Leu Thr  Lys Arg Ser Ala Val  Glu Gly Met Pro Ser  Asn Leu Asp 
    1595                 1600                 1605             


Ser Glu  Val Ala Trp Gly Lys  Ala Thr Gln Lys Glu  Ile Glu Lys 
    1610                 1615                 1620             


Gln Lys  Val His Leu Lys Ser  Ile Thr Glu Val Gly  Glu Ala Leu 
    1625                 1630                 1635             


Lys Thr  Val Leu Gly Lys Lys  Glu Thr Leu Val Glu  Asp Lys Leu 
    1640                 1645                 1650             


Ser Leu  Leu Asn Ser Asn Trp  Ile Ala Val Thr Ser  Arg Ala Glu 
    1655                 1660                 1665             


Glu Trp  Leu Asn Leu Leu Leu  Glu Tyr Gln Lys His  Met Glu Thr 
    1670                 1675                 1680             


Phe Asp  Gln Asn Val Asp His  Ile Thr Lys Trp Ile  Ile Gln Ala 
    1685                 1690                 1695             


Asp Thr  Leu Leu Asp Glu Ser  Glu Lys Lys Lys Pro  Gln Gln Lys 
    1700                 1705                 1710             


Glu Asp  Val Leu Lys Arg Leu  Lys Ala Glu Leu Asn  Asp Ile Arg 
    1715                 1720                 1725             


Pro Lys  Val Asp Ser Thr Arg  Asp Gln Ala Ala Asn  Leu Met Ala 
    1730                 1735                 1740             


Asn Arg  Gly Asp His Cys Arg  Lys Leu Val Glu Pro  Gln Ile Ser 
    1745                 1750                 1755             


Glu Leu  Asn His Arg Phe Ala  Ala Ile Ser His Arg  Ile Lys Thr 
    1760                 1765                 1770             


Gly Lys  Ala Ser Ile Pro Leu  Lys Glu Leu Glu Gln  Phe Asn Ser 
    1775                 1780                 1785             


Asp Ile  Gln Lys Leu Leu Glu  Pro Leu Glu Ala Glu  Ile Gln Gln 
    1790                 1795                 1800             


Gly Val  Asn Leu Lys Glu Glu  Asp Phe Asn Lys Asp  Met Asn Glu 
    1805                 1810                 1815             


Asp Asn  Glu Gly Thr Val Lys  Glu Leu Leu Gln Arg  Gly Asp Asn 
    1820                 1825                 1830             


Leu Gln  Gln Arg Ile Thr Asp  Glu Arg Lys Arg Glu  Glu Ile Lys 
    1835                 1840                 1845             


Ile Lys  Gln Gln Leu Leu Gln  Thr Lys His Asn Ala  Leu Lys Asp 
    1850                 1855                 1860             


Leu Arg  Ser Gln Arg Arg Lys  Lys Ala Leu Glu Ile  Ser His Gln 
    1865                 1870                 1875             


Trp Tyr  Gln Tyr Lys Arg Gln  Ala Asp Asp Leu Leu  Lys Cys Leu 
    1880                 1885                 1890             


Asp Asp  Ile Glu Lys Lys Leu  Ala Ser Leu Pro Glu  Pro Arg Asp 
    1895                 1900                 1905             


Glu Arg  Lys Ile Lys Glu Ile  Asp Arg Glu Leu Gln  Lys Lys Lys 
    1910                 1915                 1920             


Glu Glu  Leu Asn Ala Val Arg  Arg Gln Ala Glu Gly  Leu Ser Glu 
    1925                 1930                 1935             


Asp Gly  Ala Ala Met Ala Val  Glu Pro Thr Gln Ile  Gln Leu Ser 
    1940                 1945                 1950             


Lys Arg  Trp Arg Glu Ile Glu  Ser Lys Phe Ala Gln  Phe Arg Arg 
    1955                 1960                 1965             


Leu Asn  Phe Ala Gln Ile His  Thr Val Arg Glu Glu  Thr Met Met 
    1970                 1975                 1980             


Val Met  Thr Glu Asp Met Pro  Leu Glu Ile Ser Tyr  Val Pro Ser 
    1985                 1990                 1995             


Thr Tyr  Leu Thr Glu Ile Thr  His Val Ser Gln Ala  Leu Leu Glu 
    2000                 2005                 2010             


Val Glu  Gln Leu Leu Asn Ala  Pro Asp Leu Cys Ala  Lys Asp Phe 
    2015                 2020                 2025             


Glu Asp  Leu Phe Lys Gln Glu  Glu Ser Leu Lys Asn  Ile Lys Asp 
    2030                 2035                 2040             


Ser Leu  Gln Gln Ser Ser Gly  Arg Ile Asp Ile Ile  His Ser Lys 
    2045                 2050                 2055             


Lys Thr  Ala Ala Leu Gln Ser  Ala Thr Pro Val Glu  Arg Val Lys 
    2060                 2065                 2070             


Leu Gln  Glu Ala Leu Ser Gln  Leu Asp Phe Gln Trp  Glu Lys Val 
    2075                 2080                 2085             


Asn Lys  Met Tyr Lys Asp Arg  Gln Gly Arg Phe Asp  Arg Ser Val 
    2090                 2095                 2100             


Glu Lys  Trp Arg Arg Phe His  Tyr Asp Ile Lys Ile  Phe Asn Gln 
    2105                 2110                 2115             


Trp Leu  Thr Glu Ala Glu Gln  Phe Leu Arg Lys Thr  Gln Ile Pro 
    2120                 2125                 2130             


Glu Asn  Trp Glu His Ala Lys  Tyr Lys Trp Tyr Leu  Lys Glu Leu 
    2135                 2140                 2145             


Gln Asp  Gly Ile Gly Gln Arg  Gln Thr Val Val Arg  Thr Leu Asn 
    2150                 2155                 2160             


Ala Thr  Gly Glu Glu Ile Ile  Gln Gln Ser Ser Lys  Thr Asp Ala 
    2165                 2170                 2175             


Ser Ile  Leu Gln Glu Lys Leu  Gly Ser Leu Asn Leu  Arg Trp Gln 
    2180                 2185                 2190             


Glu Val  Cys Lys Gln Leu Ser  Asp Arg Lys Lys Arg  Leu Glu Glu 
    2195                 2200                 2205             


Gln Lys  Asn Ile Leu Ser Glu  Phe Gln Arg Asp Leu  Asn Glu Phe 
    2210                 2215                 2220             


Val Leu  Trp Leu Glu Glu Ala  Asp Asn Ile Ala Ser  Ile Pro Leu 
    2225                 2230                 2235             


Glu Pro  Gly Lys Glu Gln Gln  Leu Lys Glu Lys Leu  Glu Gln Val 
    2240                 2245                 2250             


Lys Leu  Leu Val Glu Glu Leu  Pro Leu Arg Gln Gly  Ile Leu Lys 
    2255                 2260                 2265             


Gln Leu  Asn Glu Thr Gly Gly  Pro Val Leu Val Ser  Ala Pro Ile 
    2270                 2275                 2280             


Ser Pro  Glu Glu Gln Asp Lys  Leu Glu Asn Lys Leu  Lys Gln Thr 
    2285                 2290                 2295             


Asn Leu  Gln Trp Ile Lys Val  Ser Arg Ala Leu Pro  Glu Lys Gln 
    2300                 2305                 2310             


Gly Glu  Ile Glu Ala Gln Ile  Lys Asp Leu Gly Gln  Leu Glu Lys 
    2315                 2320                 2325             


Lys Leu  Glu Asp Leu Glu Glu  Gln Leu Asn His Leu  Leu Leu Trp 
    2330                 2335                 2340             


Leu Ser  Pro Ile Arg Asn Gln  Leu Glu Ile Tyr Asn  Gln Pro Asn 
    2345                 2350                 2355             


Gln Glu  Gly Pro Phe Asp Val  Lys Glu Thr Glu Ile  Ala Val Gln 
    2360                 2365                 2370             


Ala Lys  Gln Pro Asp Val Glu  Glu Ile Leu Ser Lys  Gly Gln His 
    2375                 2380                 2385             


Leu Tyr  Lys Glu Lys Pro Ala  Thr Gln Pro Val Lys  Arg Lys Leu 
    2390                 2395                 2400             


Glu Asp  Leu Ser Ser Glu Trp  Lys Ala Val Asn Arg  Leu Leu Gln 
    2405                 2410                 2415             


Glu Leu  Arg Ala Lys Gln Pro  Asp Leu Ala Pro Gly  Leu Thr Thr 
    2420                 2425                 2430             


Ile Gly  Ala Ser Pro Thr Gln  Thr Val Thr Leu Val  Thr Gln Pro 
    2435                 2440                 2445             


Val Val  Thr Lys Glu Thr Ala  Ile Ser Lys Leu Glu  Met Pro Ser 
    2450                 2455                 2460             


Ser Leu  Met Leu Glu Val Pro  Ala Leu Ala Asp Phe  Asn Arg Ala 
    2465                 2470                 2475             


Trp Thr  Glu Leu Thr Asp Trp  Leu Ser Leu Leu Asp  Gln Val Ile 
    2480                 2485                 2490             


Lys Ser  Gln Arg Val Met Val  Gly Asp Leu Glu Asp  Ile Asn Glu 
    2495                 2500                 2505             


Met Ile  Ile Lys Gln Lys Ala  Thr Met Gln Asp Leu  Glu Gln Arg 
    2510                 2515                 2520             


Arg Pro  Gln Leu Glu Glu Leu  Ile Thr Ala Ala Gln  Asn Leu Lys 
    2525                 2530                 2535             


Asn Lys  Thr Ser Asn Gln Glu  Ala Arg Thr Ile Ile  Thr Asp Arg 
    2540                 2545                 2550             


Ile Glu  Arg Ile Gln Asn Gln  Trp Asp Glu Val Gln  Glu His Leu 
    2555                 2560                 2565             


Gln Asn  Arg Arg Gln Gln Leu  Asn Glu Met Leu Lys  Asp Ser Thr 
    2570                 2575                 2580             


Gln Trp  Leu Glu Ala Lys Glu  Glu Ala Glu Gln Val  Leu Gly Gln 
    2585                 2590                 2595             


Ala Arg  Ala Lys Leu Glu Ser  Trp Lys Glu Gly Pro  Tyr Thr Val 
    2600                 2605                 2610             


Asp Ala  Ile Gln Lys Lys Ile  Thr Glu Thr Lys Gln  Leu Ala Lys 
    2615                 2620                 2625             


Asp Leu  Arg Gln Trp Gln Thr  Asn Val Asp Val Ala  Asn Asp Leu 
    2630                 2635                 2640             


Ala Leu  Lys Leu Leu Arg Asp  Tyr Ser Ala Asp Asp  Thr Arg Lys 
    2645                 2650                 2655             


Val His  Met Ile Thr Glu Asn  Ile Asn Ala Ser Trp  Arg Ser Ile 
    2660                 2665                 2670             


His Lys  Arg Val Ser Glu Arg  Glu Ala Ala Leu Glu  Glu Thr His 
    2675                 2680                 2685             


Arg Leu  Leu Gln Gln Phe Pro  Leu Asp Leu Glu Lys  Phe Leu Ala 
    2690                 2695                 2700             


Trp Leu  Thr Glu Ala Glu Thr  Thr Ala Asn Val Leu  Gln Asp Ala 
    2705                 2710                 2715             


Thr Arg  Lys Glu Arg Leu Leu  Glu Asp Ser Lys Gly  Val Lys Glu 
    2720                 2725                 2730             


Leu Met  Lys Gln Trp Gln Asp  Leu Gln Gly Glu Ile  Glu Ala His 
    2735                 2740                 2745             


Thr Asp  Val Tyr His Asn Leu  Asp Glu Asn Ser Gln  Lys Ile Leu 
    2750                 2755                 2760             


Arg Ser  Leu Glu Gly Ser Asp  Asp Ala Val Leu Leu  Gln Arg Arg 
    2765                 2770                 2775             


Leu Asp  Asn Met Asn Phe Lys  Trp Ser Glu Leu Arg  Lys Lys Ser 
    2780                 2785                 2790             


Leu Asn  Ile Arg Ser His Leu  Glu Ala Ser Ser Asp  Gln Trp Lys 
    2795                 2800                 2805             


Arg Leu  His Leu Ser Leu Gln  Glu Leu Leu Val Trp  Leu Gln Leu 
    2810                 2815                 2820             


Lys Asp  Asp Glu Leu Ser Arg  Gln Ala Pro Ile Gly  Gly Asp Phe 
    2825                 2830                 2835             


Pro Ala  Val Gln Lys Gln Asn  Asp Val His Arg Ala  Phe Lys Arg 
    2840                 2845                 2850             


Glu Leu  Lys Thr Lys Glu Pro  Val Ile Met Ser Thr  Leu Glu Thr 
    2855                 2860                 2865             


Val Arg  Ile Phe Leu Thr Glu  Gln Pro Leu Glu Gly  Leu Glu Lys 
    2870                 2875                 2880             


Leu Tyr  Gln Glu Pro Arg Glu  Leu Pro Pro Glu Glu  Arg Ala Gln 
    2885                 2890                 2895             


Asn Val  Thr Arg Leu Leu Arg  Lys Gln Ala Glu Glu  Val Asn Thr 
    2900                 2905                 2910             


Glu Trp  Glu Lys Leu Asn Leu  His Ser Ala Asp Trp  Gln Arg Lys 
    2915                 2920                 2925             


Ile Asp  Glu Thr Leu Glu Arg  Leu Gln Glu Leu Gln  Glu Ala Thr 
    2930                 2935                 2940             


Asp Glu  Leu Asp Leu Lys Leu  Arg Gln Ala Glu Val  Ile Lys Gly 
    2945                 2950                 2955             


Ser Trp  Gln Pro Val Gly Asp  Leu Leu Ile Asp Ser  Leu Gln Asp 
    2960                 2965                 2970             


His Leu  Glu Lys Val Lys Ala  Leu Arg Gly Glu Ile  Ala Pro Leu 
    2975                 2980                 2985             


Lys Glu  Asn Val Ser His Val  Asn Asp Leu Ala Arg  Gln Leu Thr 
    2990                 2995                 3000             


Thr Leu  Gly Ile Gln Leu Ser  Pro Tyr Asn Leu Ser  Thr Leu Glu 
    3005                 3010                 3015             


Asp Leu  Asn Thr Arg Trp Lys  Leu Leu Gln Val Ala  Val Glu Asp 
    3020                 3025                 3030             


Arg Val  Arg Gln Leu His Glu  Ala His Arg Asp Phe  Gly Pro Ala 
    3035                 3040                 3045             


Ser Gln  His Phe Leu Ser Thr  Ser Val Gln Gly Pro  Trp Glu Arg 
    3050                 3055                 3060             


Ala Ile  Ser Pro Asn Lys Val  Pro Tyr Tyr Ile Asn  His Glu Thr 
    3065                 3070                 3075             


Gln Thr  Thr Cys Trp Asp His  Pro Lys Met Thr Glu  Leu Tyr Gln 
    3080                 3085                 3090             


Ser Leu  Ala Asp Leu Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr 
    3095                 3100                 3105             


Ala Met  Lys Leu Arg Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu 
    3110                 3115                 3120             


Leu Ser  Leu Ser Ala Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu 
    3125                 3130                 3135             


Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys 
    3140                 3145                 3150             


Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu 
    3155                 3160                 3165             


Val Asn  Val Pro Leu Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu 
    3170                 3175                 3180             


Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser 
    3185                 3190                 3195             


Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp 
    3200                 3205                 3210             


Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe 
    3215                 3220                 3225             


Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln 
    3230                 3235                 3240             


Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn 
    3245                 3250                 3255             


Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys 
    3260                 3265                 3270             


Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu 
    3275                 3280                 3285             


Pro Gln  Ser Met Val Trp Leu  Pro Val Leu His Arg  Val Ala Ala 
    3290                 3295                 3300             


Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu 
    3305                 3310                 3315             


Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn 
    3320                 3325                 3330             


Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys 
    3335                 3340                 3345             


Gly His  Lys Met His Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr 
    3350                 3355                 3360             


Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn 
    3365                 3370                 3375             


Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly 
    3380                 3385                 3390             


Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr 
    3395                 3400                 3405             


Pro Val  Thr Leu Ile Asn Phe  Trp Pro Val Asp Ser  Ala Pro Ala 
    3410                 3415                 3420             


Ser Ser  Pro Gln Leu Ser His  Asp Asp Thr His Ser  Arg Ile Glu 
    3425                 3430                 3435             


His Tyr  Ala Ser Arg Leu Ala  Glu Met Glu Asn Ser  Asn Gly Ser 
    3440                 3445                 3450             


Tyr Leu  Asn Asp Ser Ile Ser  Pro Asn Glu Ser Ile  Asp Asp Glu 
    3455                 3460                 3465             


His Leu  Leu Ile Gln His Tyr  Cys Gln Ser Leu Asn  Gln Asp Ser 
    3470                 3475                 3480             


Pro Leu  Ser Gln Pro Arg Ser  Pro Ala Gln Ile Leu  Ile Ser Leu 
    3485                 3490                 3495             


Glu Ser  Glu Glu Arg Gly Glu  Leu Glu Arg Ile Leu  Ala Asp Leu 
    3500                 3505                 3510             


Glu Glu  Glu Asn Arg Asn Leu  Gln Ala Glu Tyr Asp  Arg Leu Lys 
    3515                 3520                 3525             


Gln Gln  His Glu His Lys Gly  Leu Ser Pro Leu Pro  Ser Pro Pro 
    3530                 3535                 3540             


Glu Met  Met Pro Thr Ser Pro  Gln Ser Pro Arg Asp  Ala Glu Leu 
    3545                 3550                 3555             


Ile Ala  Glu Ala Lys Leu Leu  Arg Gln His Lys Gly  Arg Leu Glu 
    3560                 3565                 3570             


Ala Arg  Met Gln Ile Leu Glu  Asp His Asn Lys Gln  Leu Glu Ser 
    3575                 3580                 3585             


Gln Leu  His Arg Leu Arg Gln  Leu Leu Glu Gln Pro  Gln Ala Glu 
    3590                 3595                 3600             


Ala Lys  Val Asn Gly Thr Thr  Val Ser Ser Pro Ser  Thr Ser Leu 
    3605                 3610                 3615             


Gln Arg  Ser Asp Ser Ser Gln  Pro Met Leu Leu Arg  Val Val Gly 
    3620                 3625                 3630             


Ser Gln  Thr Ser Asp Ser Met  Gly Glu Glu Asp Leu  Leu Ser Pro 
    3635                 3640                 3645             


Pro Gln  Asp Thr Ser Thr Gly  Leu Glu Glu Val Met  Glu Gln Leu 
    3650                 3655                 3660             


Asn Asn  Ser Phe Pro Ser Ser  Arg Gly Arg Asn Thr  Pro Gly Lys 
    3665                 3670                 3675             


Pro Met  Arg Glu Asp Thr Met  
    3680                 3685 


<210>  69
<211>  420
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q86TJ2
<309>  2016-09-07
<313>  (1)..(420)

<400>  69

Met Ala Glu Leu Gly Lys Lys Tyr Cys Val Tyr Cys Leu Ala Glu Val 
1               5                   10                  15      


Ser Pro Leu Arg Phe Arg Cys Thr Glu Cys Gln Asp Ile Glu Leu Cys 
            20                  25                  30          


Pro Glu Cys Phe Ser Ala Gly Ala Glu Ile Gly His His Arg Arg Tyr 
        35                  40                  45              


His Gly Tyr Gln Leu Val Asp Gly Gly Arg Phe Thr Leu Trp Gly Pro 
    50                  55                  60                  


Glu Ala Glu Gly Gly Trp Thr Ser Arg Glu Glu Gln Leu Leu Leu Asp 
65                  70                  75                  80  


Ala Ile Glu Gln Phe Gly Phe Gly Asn Trp Glu Asp Met Ala Ala His 
                85                  90                  95      


Val Gly Ala Ser Arg Thr Pro Gln Glu Val Met Glu His Tyr Val Ser 
            100                 105                 110         


Met Tyr Ile His Gly Asn Leu Gly Lys Ala Cys Ile Pro Asp Thr Ile 
        115                 120                 125             


Pro Asn Arg Val Thr Asp His Thr Cys Pro Ser Gly Gly Pro Leu Ser 
    130                 135                 140                 


Pro Ser Leu Thr Thr Pro Leu Pro Pro Leu Asp Ile Ser Val Ala Glu 
145                 150                 155                 160 


Gln Gln Gln Leu Gly Tyr Met Pro Leu Arg Asp Asp Tyr Glu Ile Glu 
                165                 170                 175     


Tyr Asp Gln Asp Ala Glu Thr Leu Ile Ser Gly Leu Ser Val Asn Tyr 
            180                 185                 190         


Asp Asp Asp Asp Val Glu Ile Glu Leu Lys Arg Ala His Val Asp Met 
        195                 200                 205             


Tyr Val Arg Lys Leu Lys Glu Arg Gln Arg Arg Lys Asn Ile Ala Arg 
    210                 215                 220                 


Asp Tyr Asn Leu Val Pro Ala Phe Leu Gly Lys Asp Lys Lys Glu Lys 
225                 230                 235                 240 


Glu Lys Ala Leu Lys Arg Lys Ile Thr Lys Glu Glu Lys Glu Leu Arg 
                245                 250                 255     


Leu Lys Leu Arg Pro Leu Tyr Gln Phe Met Ser Cys Lys Glu Phe Asp 
            260                 265                 270         


Asp Leu Phe Glu Asn Met His Lys Glu Lys Met Leu Arg Ala Lys Ile 
        275                 280                 285             


Arg Glu Leu Gln Arg Tyr Arg Arg Asn Gly Ile Thr Lys Met Glu Glu 
    290                 295                 300                 


Ser Ala Glu Tyr Glu Ala Ala Arg His Lys Arg Glu Lys Arg Lys Glu 
305                 310                 315                 320 


Asn Lys Asn Leu Ala Gly Ser Lys Arg Gly Lys Glu Asp Gly Lys Asp 
                325                 330                 335     


Ser Glu Phe Ala Ala Ile Glu Asn Leu Pro Gly Phe Glu Leu Leu Ser 
            340                 345                 350         


Asp Arg Glu Lys Val Leu Cys Ser Ser Leu Asn Leu Ser Pro Ala Arg 
        355                 360                 365             


Tyr Val Thr Val Lys Thr Ile Ile Ile Lys Asp His Leu Gln Lys Arg 
    370                 375                 380                 


Gln Gly Ile Pro Ser Lys Ser Arg Leu Pro Ser Tyr Leu Asp Lys Val 
385                 390                 395                 400 


Leu Lys Lys Arg Ile Leu Asn Phe Leu Thr Glu Ser Gly Trp Ile Ser 
                405                 410                 415     


Arg Asp Ala Ser 
            420 


<210>  70
<211>  3753
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q709C8
<309>  2016-09-07
<313>  (1)..(3753)

<400>  70

Met Val Leu Glu Ser Val Val Ala Asp Leu Leu Asn Arg Phe Leu Gly 
1               5                   10                  15      


Asp Tyr Val Glu Asn Leu Asn Lys Ser Gln Leu Lys Leu Gly Ile Trp 
            20                  25                  30          


Gly Gly Asn Val Ala Leu Asp Asn Leu Gln Ile Lys Glu Asn Ala Leu 
        35                  40                  45              


Ser Glu Leu Asp Val Pro Phe Lys Val Lys Ala Gly Gln Ile Asp Lys 
    50                  55                  60                  


Leu Thr Leu Lys Ile Pro Trp Lys Asn Leu Tyr Gly Glu Ala Val Val 
65                  70                  75                  80  


Ala Thr Leu Glu Gly Leu Tyr Leu Leu Val Val Pro Gly Ala Ser Ile 
                85                  90                  95      


Lys Tyr Asp Ala Val Lys Glu Glu Lys Ser Leu Gln Asp Val Lys Gln 
            100                 105                 110         


Lys Glu Leu Ser Arg Ile Glu Glu Ala Leu Gln Lys Ala Ala Glu Lys 
        115                 120                 125             


Gly Thr His Ser Gly Glu Phe Ile Tyr Gly Leu Glu Asn Phe Val Tyr 
    130                 135                 140                 


Lys Asp Ile Lys Pro Gly Arg Lys Arg Lys Lys His Lys Lys His Phe 
145                 150                 155                 160 


Lys Lys Pro Phe Lys Gly Leu Asp Arg Ser Lys Asp Lys Pro Lys Glu 
                165                 170                 175     


Ala Lys Lys Asp Thr Phe Val Glu Lys Leu Ala Thr Gln Val Ile Lys 
            180                 185                 190         


Asn Val Gln Val Lys Ile Thr Asp Ile His Ile Lys Tyr Glu Asp Asp 
        195                 200                 205             


Val Thr Asp Pro Lys Arg Pro Leu Ser Phe Gly Val Thr Leu Gly Glu 
    210                 215                 220                 


Leu Ser Leu Leu Thr Ala Asn Glu His Trp Thr Pro Cys Ile Leu Asn 
225                 230                 235                 240 


Glu Ala Asp Lys Ile Ile Tyr Lys Leu Ile Arg Leu Asp Ser Leu Ser 
                245                 250                 255     


Ala Tyr Trp Asn Val Asn Cys Ser Met Ser Tyr Gln Arg Ser Arg Glu 
            260                 265                 270         


Gln Ile Leu Asp Gln Leu Lys Asn Glu Ile Leu Thr Ser Gly Asn Ile 
        275                 280                 285             


Pro Pro Asn Tyr Gln Tyr Ile Phe Gln Pro Ile Ser Ala Ser Ala Lys 
    290                 295                 300                 


Leu Tyr Met Asn Pro Tyr Ala Glu Ser Glu Leu Lys Thr Pro Lys Leu 
305                 310                 315                 320 


Asp Cys Asn Ile Glu Ile Gln Asn Ile Ala Ile Glu Leu Thr Lys Pro 
                325                 330                 335     


Gln Tyr Leu Ser Met Ile Asp Leu Leu Glu Ser Val Asp Tyr Met Val 
            340                 345                 350         


Arg Asn Ala Pro Tyr Arg Lys Tyr Lys Pro Tyr Leu Pro Leu His Thr 
        355                 360                 365             


Asn Gly Arg Arg Trp Trp Lys Tyr Ala Ile Asp Ser Val Leu Glu Val 
    370                 375                 380                 


His Ile Arg Arg Tyr Thr Gln Met Trp Ser Trp Ser Asn Ile Lys Lys 
385                 390                 395                 400 


His Arg Gln Leu Leu Lys Ser Tyr Lys Ile Ala Tyr Lys Asn Lys Leu 
                405                 410                 415     


Thr Gln Ser Lys Val Ser Glu Glu Ile Gln Lys Glu Ile Gln Asp Leu 
            420                 425                 430         


Glu Lys Thr Leu Asp Val Phe Asn Ile Ile Leu Ala Arg Gln Gln Ala 
        435                 440                 445             


Gln Val Glu Val Ile Arg Ser Gly Gln Lys Leu Arg Lys Lys Ser Ala 
    450                 455                 460                 


Asp Thr Gly Glu Lys Arg Gly Gly Trp Phe Ser Gly Leu Trp Gly Lys 
465                 470                 475                 480 


Lys Glu Ser Lys Lys Lys Asp Glu Glu Ser Leu Ile Pro Glu Thr Ile 
                485                 490                 495     


Asp Asp Leu Met Thr Pro Glu Glu Lys Asp Lys Leu Phe Thr Ala Ile 
            500                 505                 510         


Gly Tyr Ser Glu Ser Thr His Asn Leu Thr Leu Pro Lys Gln Tyr Val 
        515                 520                 525             


Ala His Ile Met Thr Leu Lys Leu Val Ser Thr Ser Val Thr Ile Arg 
    530                 535                 540                 


Glu Asn Lys Asn Ile Pro Glu Ile Leu Lys Ile Gln Ile Ile Gly Leu 
545                 550                 555                 560 


Gly Thr Gln Val Ser Gln Arg Pro Gly Ala Gln Ala Leu Lys Val Glu 
                565                 570                 575     


Ala Lys Leu Glu His Trp Tyr Ile Thr Gly Leu Arg Gln Gln Asp Ile 
            580                 585                 590         


Val Pro Ser Leu Val Ala Ser Ile Gly Asp Thr Thr Ser Ser Leu Leu 
        595                 600                 605             


Lys Ile Lys Phe Glu Thr Asn Pro Glu Asp Ser Pro Ala Asp Gln Thr 
    610                 615                 620                 


Leu Ile Val Gln Ser Gln Pro Val Glu Val Ile Tyr Asp Ala Lys Thr 
625                 630                 635                 640 


Val Asn Ala Val Val Glu Phe Phe Gln Ser Asn Lys Gly Leu Asp Leu 
                645                 650                 655     


Glu Gln Ile Thr Ser Ala Thr Leu Met Lys Leu Glu Glu Ile Lys Glu 
            660                 665                 670         


Arg Thr Ala Thr Gly Leu Thr His Ile Ile Glu Thr Arg Lys Val Leu 
        675                 680                 685             


Asp Leu Arg Ile Asn Leu Lys Pro Ser Tyr Leu Val Val Pro Gln Thr 
    690                 695                 700                 


Gly Phe His His Glu Lys Ser Asp Leu Leu Ile Leu Asp Phe Gly Thr 
705                 710                 715                 720 


Phe Gln Leu Asn Ser Lys Asp Gln Gly Leu Gln Lys Thr Thr Asn Ser 
                725                 730                 735     


Ser Leu Glu Glu Ile Met Asp Lys Ala Tyr Asp Lys Phe Asp Val Glu 
            740                 745                 750         


Ile Lys Asn Val Gln Leu Leu Phe Ala Arg Ala Glu Glu Thr Trp Lys 
        755                 760                 765             


Lys Cys Arg Phe Gln His Pro Ser Thr Met His Ile Leu Gln Pro Met 
    770                 775                 780                 


Asp Ile His Val Glu Leu Ala Lys Ala Met Val Glu Lys Asp Ile Arg 
785                 790                 795                 800 


Met Ala Arg Phe Lys Val Ser Gly Gly Leu Pro Leu Met His Val Arg 
                805                 810                 815     


Ile Ser Asp Gln Lys Met Lys Asp Val Leu Tyr Leu Met Asn Ser Ile 
            820                 825                 830         


Pro Leu Pro Gln Lys Ser Ser Ala Gln Ser Pro Glu Arg Gln Val Ser 
        835                 840                 845             


Ser Ile Pro Ile Ile Ser Gly Gly Thr Lys Gly Leu Leu Gly Thr Ser 
    850                 855                 860                 


Leu Leu Leu Asp Thr Val Glu Ser Glu Ser Asp Asp Glu Tyr Phe Asp 
865                 870                 875                 880 


Ala Glu Asp Gly Glu Pro Gln Thr Cys Lys Ser Met Lys Gly Ser Glu 
                885                 890                 895     


Leu Lys Lys Ala Ala Glu Val Pro Asn Glu Glu Leu Ile Asn Leu Leu 
            900                 905                 910         


Leu Lys Phe Glu Ile Lys Glu Val Ile Leu Glu Phe Thr Lys Gln Gln 
        915                 920                 925             


Lys Glu Glu Asp Thr Ile Leu Val Phe Asn Val Thr Gln Leu Gly Thr 
    930                 935                 940                 


Glu Ala Thr Met Arg Thr Phe Asp Leu Thr Val Val Ser Tyr Leu Lys 
945                 950                 955                 960 


Lys Ile Ser Leu Asp Tyr His Glu Ile Glu Gly Ser Lys Arg Lys Pro 
                965                 970                 975     


Leu His Leu Ile Ser Ser Ser Asp Lys Pro Gly Leu Asp Leu Leu Lys 
            980                 985                 990         


Val Glu Tyr Ile Lys Ala Asp Lys  Asn Gly Pro Ser Phe  Gln Thr Ala 
        995                 1000                 1005             


Phe Gly  Lys Thr Glu Gln Thr  Val Lys Val Ala Phe  Ser Ser Leu 
    1010                 1015                 1020             


Asn Leu  Leu Leu Gln Thr Gln  Ala Leu Val Ala Ser  Ile Asn Tyr 
    1025                 1030                 1035             


Leu Thr  Thr Ile Ile Pro Ser  Asp Asp Gln Ser Ile  Ser Val Ala 
    1040                 1045                 1050             


Lys Glu  Val Gln Ile Ser Thr  Glu Lys Gln Gln Lys  Asn Ser Thr 
    1055                 1060                 1065             


Leu Pro  Lys Ala Ile Val Ser  Ser Arg Asp Ser Asp  Ile Ile Asp 
    1070                 1075                 1080             


Phe Arg  Leu Phe Ala Lys Leu  Asn Ala Phe Cys Val  Ile Val Cys 
    1085                 1090                 1095             


Asn Glu  Lys Asn Asn Ile Ala  Glu Ile Lys Ile Gln  Gly Leu Asp 
    1100                 1105                 1110             


Ser Ser  Leu Ser Leu Gln Ser  Arg Lys Gln Ser Leu  Phe Ala Arg 
    1115                 1120                 1125             


Leu Glu  Asn Ile Ile Val Thr  Asp Val Asp Pro Lys  Thr Val His 
    1130                 1135                 1140             


Lys Lys  Ala Val Ser Ile Met  Gly Asn Glu Val Phe  Arg Phe Asn 
    1145                 1150                 1155             


Leu Asp  Leu Tyr Pro Asp Ala  Thr Glu Gly Asp Leu  Tyr Thr Asp 
    1160                 1165                 1170             


Met Ser  Lys Val Asp Gly Val  Leu Ser Leu Asn Val  Gly Cys Ile 
    1175                 1180                 1185             


Gln Ile  Val Tyr Leu His Lys  Phe Leu Met Ser Leu  Leu Asn Phe 
    1190                 1195                 1200             


Leu Asn  Asn Phe Gln Thr Ala  Lys Glu Ser Leu Ser  Ala Ala Thr 
    1205                 1210                 1215             


Ala Gln  Ala Ala Glu Arg Ala  Ala Thr Ser Val Lys  Asp Leu Ala 
    1220                 1225                 1230             


Gln Arg  Ser Phe Arg Val Ser  Ile Asn Ile Asp Leu  Lys Ala Pro 
    1235                 1240                 1245             


Val Ile  Val Ile Pro Gln Ser  Ser Ile Ser Thr Asn  Ala Val Val 
    1250                 1255                 1260             


Val Asp  Leu Gly Leu Ile Arg  Val His Asn Gln Phe  Ser Leu Val 
    1265                 1270                 1275             


Ser Asp  Glu Asp Tyr Leu Asn  Pro Pro Val Ile Asp  Arg Met Asp 
    1280                 1285                 1290             


Val Gln  Leu Thr Lys Leu Thr  Leu Tyr Arg Thr Val  Ile Gln Pro 
    1295                 1300                 1305             


Gly Ile  Tyr His Pro Asp Ile  Gln Leu Leu His Pro  Ile Asn Leu 
    1310                 1315                 1320             


Glu Phe  Leu Val Asn Arg Asn  Leu Ala Ala Ser Trp  Tyr His Lys 
    1325                 1330                 1335             


Val Pro  Val Val Glu Ile Lys  Gly His Leu Asp Ser  Met Asn Val 
    1340                 1345                 1350             


Ser Leu  Asn Gln Glu Asp Leu  Asn Leu Leu Phe Arg  Ile Leu Thr 
    1355                 1360                 1365             


Glu Asn  Leu Cys Glu Gly Thr  Glu Asp Leu Asp Lys  Val Lys Pro 
    1370                 1375                 1380             


Arg Val  Gln Glu Thr Gly Glu  Ile Lys Glu Pro Leu  Glu Ile Ser 
    1385                 1390                 1395             


Ile Ser  Gln Asp Val His Asp  Ser Lys Asn Thr Leu  Thr Thr Gly 
    1400                 1405                 1410             


Val Glu  Glu Ile Arg Ser Val  Asp Ile Ile Asn Met  Leu Leu Asn 
    1415                 1420                 1425             


Phe Glu  Ile Lys Glu Val Val  Val Thr Leu Met Lys  Lys Ser Glu 
    1430                 1435                 1440             


Lys Lys  Gly Arg Pro Leu His  Glu Leu Asn Val Leu  Gln Leu Gly 
    1445                 1450                 1455             


Met Glu  Ala Lys Val Lys Thr  Tyr Asp Met Thr Ala  Lys Ala Tyr 
    1460                 1465                 1470             


Leu Lys  Lys Ile Ser Met Gln  Cys Phe Asp Phe Thr  Asp Ser Lys 
    1475                 1480                 1485             


Gly Glu  Pro Leu His Ile Ile  Asn Ser Ser Asn Val  Thr Asp Glu 
    1490                 1495                 1500             


Pro Leu  Leu Lys Met Leu Leu  Thr Lys Ala Asp Ser  Asp Gly Pro 
    1505                 1510                 1515             


Glu Phe  Lys Thr Ile His Asp  Ser Thr Lys Gln Arg  Leu Lys Val 
    1520                 1525                 1530             


Ser Phe  Ala Ser Leu Asp Leu  Val Leu His Leu Glu  Ala Leu Leu 
    1535                 1540                 1545             


Ser Phe  Met Asp Phe Leu Ser  Ser Ala Ala Pro Phe  Ser Glu Pro 
    1550                 1555                 1560             


Ser Ser  Ser Glu Lys Glu Ser  Glu Leu Lys Pro Leu  Val Gly Glu 
    1565                 1570                 1575             


Ser Arg  Ser Ile Ala Val Lys  Ala Val Ser Ser Asn  Ile Ser Gln 
    1580                 1585                 1590             


Lys Asp  Val Phe Asp Leu Lys  Ile Thr Ala Glu Leu  Asn Ala Phe 
    1595                 1600                 1605             


Asn Val  Phe Val Cys Asp Gln  Lys Cys Asn Ile Ala  Asp Ile Lys 
    1610                 1615                 1620             


Ile His  Gly Met Asp Ala Ser  Ile Ser Val Lys Pro  Lys Gln Thr 
    1625                 1630                 1635             


Asp Val  Phe Ala Arg Leu Lys  Asp Ile Ile Val Met  Asn Val Asp 
    1640                 1645                 1650             


Leu Gln  Ser Ile His Lys Lys  Ala Val Ser Ile Leu  Gly Asp Glu 
    1655                 1660                 1665             


Val Phe  Arg Phe Gln Leu Thr  Leu Tyr Pro Asp Ala  Thr Glu Gly 
    1670                 1675                 1680             


Glu Ala  Tyr Ala Asp Met Ser  Lys Val Asp Gly Lys  Leu Ser Phe 
    1685                 1690                 1695             


Lys Val  Gly Cys Ile Gln Ile  Val Tyr Val His Lys  Phe Phe Met 
    1700                 1705                 1710             


Ser Leu  Leu Asn Phe Leu Asn  Asn Phe Gln Thr Ala  Lys Glu Ala 
    1715                 1720                 1725             


Leu Ser  Thr Ala Thr Val Gln  Ala Ala Glu Arg Ala  Ala Ser Ser 
    1730                 1735                 1740             


Met Lys  Asp Leu Ala Gln Lys  Ser Phe Arg Leu Leu  Met Asp Ile 
    1745                 1750                 1755             


Asn Leu  Lys Ala Pro Val Ile  Ile Ile Pro Gln Ser  Ser Val Ser 
    1760                 1765                 1770             


Pro Asn  Ala Val Ile Ala Asp  Leu Gly Leu Ile Arg  Val Glu Asn 
    1775                 1780                 1785             


Lys Phe  Ser Leu Val Pro Met  Glu His Tyr Ser Leu  Pro Pro Val 
    1790                 1795                 1800             


Ile Asp  Lys Met Asn Ile Glu  Leu Thr Gln Leu Lys  Leu Ser Arg 
    1805                 1810                 1815             


Thr Ile  Leu Gln Ala Ser Leu  Pro Gln Asn Asp Ile  Glu Ile Leu 
    1820                 1825                 1830             


Lys Pro  Val Asn Met Leu Leu  Ser Ile Gln Arg Asn  Leu Ala Ala 
    1835                 1840                 1845             


Ala Trp  Tyr Val Gln Ile Pro  Gly Met Glu Ile Lys  Gly Lys Leu 
    1850                 1855                 1860             


Lys Pro  Met Gln Val Ala Leu  Ser Glu Asp Asp Leu  Thr Val Leu 
    1865                 1870                 1875             


Met Lys  Ile Leu Leu Glu Asn  Leu Gly Glu Ala Ser  Ser Gln Pro 
    1880                 1885                 1890             


Ser Pro  Thr Gln Ser Val Gln  Glu Thr Val Arg Val  Arg Lys Val 
    1895                 1900                 1905             


Asp Val  Ser Ser Val Pro Asp  His Leu Lys Glu Gln  Glu Asp Trp 
    1910                 1915                 1920             


Thr Asp  Ser Lys Leu Ser Met  Asn Gln Ile Val Ser  Leu Gln Phe 
    1925                 1930                 1935             


Asp Phe  His Phe Glu Ser Leu  Ser Ile Ile Leu Tyr  Asn Asn Asp 
    1940                 1945                 1950             


Ile Asn  Gln Glu Ser Gly Val  Ala Phe His Asn Asp  Ser Phe Gln 
    1955                 1960                 1965             


Leu Gly  Glu Leu Arg Leu His  Leu Met Ala Ser Ser  Gly Lys Met 
    1970                 1975                 1980             


Phe Lys  Asp Gly Ser Met Asn  Val Ser Val Lys Leu  Lys Thr Cys 
    1985                 1990                 1995             


Thr Leu  Asp Asp Leu Arg Glu  Gly Ile Glu Arg Ala  Thr Ser Arg 
    2000                 2005                 2010             


Met Ile  Asp Arg Lys Asn Asp  Gln Asp Asn Asn Ser  Ser Met Ile 
    2015                 2020                 2025             


Asp Ile  Ser Tyr Lys Gln Asp  Lys Asn Gly Ser Gln  Ile Asp Ala 
    2030                 2035                 2040             


Val Leu  Asp Lys Leu Tyr Val  Cys Ala Ser Val Glu  Phe Leu Met 
    2045                 2050                 2055             


Thr Val  Ala Asp Phe Phe Ile  Lys Ala Val Pro Gln  Ser Pro Glu 
    2060                 2065                 2070             


Asn Val  Ala Lys Glu Thr Gln  Ile Leu Pro Arg Gln  Thr Ala Thr 
    2075                 2080                 2085             


Gly Lys  Val Lys Ile Glu Lys  Asp Asp Ser Val Arg  Pro Asn Met 
    2090                 2095                 2100             


Thr Leu  Lys Ala Met Ile Thr  Asp Pro Glu Val Val  Phe Val Ala 
    2105                 2110                 2115             


Ser Leu  Thr Lys Ala Asp Ala  Pro Ala Leu Thr Ala  Ser Phe Gln 
    2120                 2125                 2130             


Cys Asn  Leu Ser Leu Ser Thr  Ser Lys Leu Glu Gln  Met Met Glu 
    2135                 2140                 2145             


Ala Ser  Val Arg Asp Leu Lys  Val Leu Ala Cys Pro  Phe Leu Arg 
    2150                 2155                 2160             


Glu Lys  Arg Gly Lys Asn Ile  Thr Thr Val Leu Gln  Pro Cys Ser 
    2165                 2170                 2175             


Leu Phe  Met Glu Lys Cys Thr  Trp Ala Ser Gly Lys  Gln Asn Ile 
    2180                 2185                 2190             


Asn Ile  Met Val Lys Glu Phe  Ile Ile Lys Ile Ser  Pro Ile Ile 
    2195                 2200                 2205             


Leu Asn  Thr Val Leu Thr Ile  Met Ala Ala Leu Ser  Pro Lys Thr 
    2210                 2215                 2220             


Lys Glu  Asp Gly Ser Lys Asp  Thr Ser Lys Glu Met  Glu Asn Leu 
    2225                 2230                 2235             


Trp Gly  Ile Lys Ser Ile Asn  Asp Tyr Asn Thr Trp  Phe Leu Gly 
    2240                 2245                 2250             


Val Asp  Thr Ala Thr Glu Ile  Thr Glu Ser Phe Lys  Gly Ile Glu 
    2255                 2260                 2265             


His Ser  Leu Ile Glu Glu Asn  Cys Gly Val Val Val  Glu Ser Ile 
    2270                 2275                 2280             


Gln Val  Thr Leu Glu Cys Gly  Leu Gly His Arg Thr  Val Pro Leu 
    2285                 2290                 2295             


Leu Leu  Ala Glu Ser Lys Phe  Ser Gly Asn Ile Lys  Asn Trp Thr 
    2300                 2305                 2310             


Ser Leu  Met Ala Ala Val Ala  Asp Val Thr Leu Gln  Val His Tyr 
    2315                 2320                 2325             


Tyr Asn  Glu Ile His Ala Val  Trp Glu Pro Leu Ile  Glu Arg Val 
    2330                 2335                 2340             


Glu Gly  Lys Arg Gln Trp Asn  Leu Arg Leu Asp Val  Lys Lys Asn 
    2345                 2350                 2355             


Pro Val  Gln Asp Lys Ser Leu  Leu Pro Gly Asp Asp  Phe Ile Pro 
    2360                 2365                 2370             


Glu Pro  Gln Met Ala Ile His  Ile Ser Ser Gly Asn  Thr Met Asn 
    2375                 2380                 2385             


Ile Thr  Ile Ser Lys Ser Cys  Leu Asn Val Phe Asn  Asn Leu Ala 
    2390                 2395                 2400             


Lys Gly  Phe Ser Glu Gly Thr  Ala Ser Thr Phe Asp  Tyr Ser Leu 
    2405                 2410                 2415             


Lys Asp  Arg Ala Pro Phe Thr  Val Lys Asn Ala Val  Gly Val Pro 
    2420                 2425                 2430             


Ile Lys  Val Lys Pro Asn Cys  Asn Leu Arg Val Met  Gly Phe Pro 
    2435                 2440                 2445             


Glu Lys  Ser Asp Ile Phe Asp  Val Asp Ala Gly Gln  Asn Leu Glu 
    2450                 2455                 2460             


Leu Glu  Tyr Ala Ser Met Val  Pro Ser Ser Gln Gly  Asn Leu Ser 
    2465                 2470                 2475             


Ile Leu  Ser Arg Gln Glu Ser  Ser Phe Phe Thr Leu  Thr Ile Val 
    2480                 2485                 2490             


Pro His  Gly Tyr Thr Glu Val  Ala Asn Ile Pro Val  Ala Arg Pro 
    2495                 2500                 2505             


Gly Arg  Arg Leu Tyr Asn Val  Arg Asn Pro Asn Ala  Ser His Ser 
    2510                 2515                 2520             


Asp Ser  Val Leu Val Gln Ile  Asp Ala Thr Glu Gly  Asn Lys Val 
    2525                 2530                 2535             


Ile Thr  Leu Arg Ser Pro Leu  Gln Ile Lys Asn His  Phe Ser Ile 
    2540                 2545                 2550             


Ala Phe  Ile Ile Tyr Lys Phe  Val Lys Asn Val Lys  Leu Leu Glu 
    2555                 2560                 2565             


Arg Ile  Gly Ile Ala Arg Pro  Glu Glu Glu Phe His  Val Pro Leu 
    2570                 2575                 2580             


Asp Ser  Tyr Arg Cys Gln Leu  Phe Ile Gln Pro Ala  Gly Ile Leu 
    2585                 2590                 2595             


Glu His  Gln Tyr Lys Glu Ser  Thr Thr Tyr Ile Ser  Trp Lys Glu 
    2600                 2605                 2610             


Glu Leu  His Arg Ser Arg Glu  Val Arg Cys Met Leu  Gln Cys Pro 
    2615                 2620                 2625             


Ser Val  Glu Val Ser Phe Leu  Pro Leu Ile Val Asn  Thr Val Ala 
    2630                 2635                 2640             


Leu Pro  Asp Glu Leu Ser Tyr  Ile Cys Thr His Gly  Glu Asp Trp 
    2645                 2650                 2655             


Asp Val  Ala Tyr Ile Ile His  Leu Tyr Pro Ser Leu  Thr Leu Arg 
    2660                 2665                 2670             


Asn Leu  Leu Pro Tyr Ser Leu  Arg Tyr Leu Leu Glu  Gly Thr Ala 
    2675                 2680                 2685             


Glu Thr  His Glu Leu Ala Glu  Gly Ser Thr Ala Asp  Val Leu His 
    2690                 2695                 2700             


Ser Arg  Ile Ser Gly Glu Ile  Met Glu Leu Val Leu  Val Lys Tyr 
    2705                 2710                 2715             


Gln Gly  Lys Asn Trp Asn Gly  His Phe Arg Ile Arg  Asp Thr Leu 
    2720                 2725                 2730             


Pro Glu  Phe Phe Pro Val Cys  Phe Ser Ser Asp Ser  Thr Glu Val 
    2735                 2740                 2745             


Thr Thr  Val Asp Leu Ser Val  His Val Arg Arg Ile  Gly Ser Arg 
    2750                 2755                 2760             


Met Val  Leu Ser Val Phe Ser  Pro Tyr Trp Leu Ile  Asn Lys Thr 
    2765                 2770                 2775             


Thr Arg  Val Leu Gln Tyr Arg  Ser Glu Asp Ile His  Val Lys His 
    2780                 2785                 2790             


Pro Ala  Asp Phe Arg Asp Ile  Ile Leu Phe Ser Phe  Lys Lys Lys 
    2795                 2800                 2805             


Asn Ile  Phe Thr Lys Asn Lys  Val Gln Leu Lys Ile  Ser Thr Ser 
    2810                 2815                 2820             


Ala Trp  Ser Ser Ser Phe Ser  Leu Asp Thr Val Gly  Ser Tyr Gly 
    2825                 2830                 2835             


Cys Val  Lys Cys Pro Ala Asn  Asn Met Glu Tyr Leu  Val Gly Val 
    2840                 2845                 2850             


Ser Ile  Lys Met Ser Ser Phe  Asn Leu Ser Arg Ile  Val Thr Leu 
    2855                 2860                 2865             


Thr Pro  Phe Cys Thr Ile Ala  Asn Lys Ser Ser Leu  Glu Leu Glu 
    2870                 2875                 2880             


Val Gly  Glu Ile Ala Ser Asp  Gly Ser Met Pro Thr  Asn Lys Trp 
    2885                 2890                 2895             


Asn Tyr  Ile Ala Ser Ser Glu  Cys Leu Pro Phe Trp  Pro Glu Ser 
    2900                 2905                 2910             


Leu Ser  Gly Lys Leu Cys Val  Arg Val Val Gly Cys  Glu Gly Ser 
    2915                 2920                 2925             


Ser Lys  Pro Phe Phe Tyr Asn  Arg Gln Asp Asn Gly  Thr Leu Leu 
    2930                 2935                 2940             


Ser Leu  Glu Asp Leu Asn Gly  Gly Ile Leu Val Asp  Val Asn Thr 
    2945                 2950                 2955             


Ala Glu  His Ser Thr Val Ile  Thr Phe Ser Asp Tyr  His Glu Gly 
    2960                 2965                 2970             


Ser Ala  Pro Ala Leu Ile Met  Asn His Thr Pro Trp  Asp Ile Leu 
    2975                 2980                 2985             


Thr Tyr  Lys Gln Ser Gly Ser  Pro Glu Glu Met Val  Leu Leu Pro 
    2990                 2995                 3000             


Arg Gln  Ala Arg Leu Phe Ala  Trp Ala Asp Pro Thr  Gly Thr Arg 
    3005                 3010                 3015             


Lys Leu  Thr Trp Thr Tyr Ala  Ala Asn Val Gly Glu  His Asp Leu 
    3020                 3025                 3030             


Leu Lys  Asp Gly Cys Gly Gln  Phe Pro Tyr Asp Ala  Asn Ile Gln 
    3035                 3040                 3045             


Ile His  Trp Val Ser Phe Leu  Asp Gly Arg Gln Arg  Val Leu Leu 
    3050                 3055                 3060             


Phe Thr  Asp Asp Val Ala Leu  Val Ser Lys Ala Leu  Gln Ala Glu 
    3065                 3070                 3075             


Glu Met  Glu Gln Ala Asp Tyr  Glu Ile Thr Leu Ser  Leu His Ser 
    3080                 3085                 3090             


Leu Gly  Leu Ser Leu Val Asn  Asn Glu Ser Lys Gln  Glu Val Ser 
    3095                 3100                 3105             


Tyr Ile  Gly Ile Thr Ser Ser  Gly Val Val Trp Glu  Val Lys Pro 
    3110                 3115                 3120             


Lys Gln  Lys Trp Lys Pro Phe  Ser Gln Lys Gln Ile  Ile Leu Leu 
    3125                 3130                 3135             


Glu Gln  Ser Tyr Gln Lys His  Gln Ile Ser Arg Asp  His Gly Trp 
    3140                 3145                 3150             


Ile Lys  Leu Asp Asn Asn Phe  Glu Val Asn Phe Asp  Lys Asp Pro 
    3155                 3160                 3165             


Met Glu  Met Arg Leu Pro Ile  Arg Ser Pro Ile Lys  Arg Asp Phe 
    3170                 3175                 3180             


Leu Ser  Gly Ile Gln Ile Glu  Phe Lys Gln Ser Ser  His Gln Arg 
    3185                 3190                 3195             


Ser Leu  Arg Ala Arg Leu Tyr  Trp Leu Gln Val Asp  Asn Gln Leu 
    3200                 3205                 3210             


Pro Gly  Ala Met Phe Pro Val  Val Phe His Pro Val  Ala Pro Pro 
    3215                 3220                 3225             


Lys Ser  Ile Ala Leu Asp Ser  Glu Pro Lys Pro Phe  Ile Asp Val 
    3230                 3235                 3240             


Ser Val  Ile Thr Arg Phe Asn  Glu Tyr Ser Lys Val  Leu Gln Phe 
    3245                 3250                 3255             


Lys Tyr  Phe Met Val Leu Ile  Gln Glu Met Ala Leu  Lys Ile Asp 
    3260                 3265                 3270             


Gln Gly  Phe Leu Gly Ala Ile  Ile Ala Leu Phe Thr  Pro Thr Thr 
    3275                 3280                 3285             


Asp Pro  Glu Ala Glu Arg Arg  Arg Thr Lys Leu Ile  Gln Gln Asp 
    3290                 3295                 3300             


Ile Asp  Ala Leu Asn Ala Glu  Leu Met Glu Thr Ser  Met Thr Asp 
    3305                 3310                 3315             


Met Ser  Ile Leu Ser Phe Phe  Glu His Phe His Ile  Ser Pro Val 
    3320                 3325                 3330             


Lys Leu  His Leu Ser Leu Ser  Leu Gly Ser Gly Gly  Glu Glu Ser 
    3335                 3340                 3345             


Asp Lys  Glu Lys Gln Glu Met  Phe Ala Val His Ser  Val Asn Leu 
    3350                 3355                 3360             


Leu Leu  Lys Ser Ile Gly Ala  Thr Leu Thr Asp Val  Asp Asp Leu 
    3365                 3370                 3375             


Ile Phe  Lys Leu Ala Tyr Tyr  Glu Ile Arg Tyr Gln  Phe Tyr Lys 
    3380                 3385                 3390             


Arg Asp  Gln Leu Ile Trp Ser  Val Val Arg His Tyr  Ser Glu Gln 
    3395                 3400                 3405             


Phe Leu  Lys Gln Met Tyr Val  Leu Val Leu Gly Leu  Asp Val Leu 
    3410                 3415                 3420             


Gly Asn  Pro Phe Gly Leu Ile  Arg Gly Leu Ser Glu  Gly Val Glu 
    3425                 3430                 3435             


Ala Leu  Phe Tyr Glu Pro Phe  Gln Gly Ala Val Gln  Gly Pro Glu 
    3440                 3445                 3450             


Glu Phe  Ala Glu Gly Leu Val  Ile Gly Val Arg Ser  Leu Phe Gly 
    3455                 3460                 3465             


His Thr  Val Gly Gly Ala Ala  Gly Val Val Ser Arg  Ile Thr Gly 
    3470                 3475                 3480             


Ser Val  Gly Lys Gly Leu Ala  Ala Ile Thr Met Asp  Lys Glu Tyr 
    3485                 3490                 3495             


Gln Gln  Lys Arg Arg Glu Glu  Leu Ser Arg Gln Pro  Arg Asp Phe 
    3500                 3505                 3510             


Gly Asp  Ser Leu Ala Arg Gly  Gly Lys Gly Phe Leu  Arg Gly Val 
    3515                 3520                 3525             


Val Gly  Gly Val Thr Gly Ile  Ile Thr Lys Pro Val  Glu Gly Ala 
    3530                 3535                 3540             


Lys Lys  Glu Gly Ala Ala Gly  Phe Phe Lys Gly Ile  Gly Lys Gly 
    3545                 3550                 3555             


Leu Val  Gly Ala Val Ala Arg  Pro Thr Gly Gly Ile  Val Asp Met 
    3560                 3565                 3570             


Ala Ser  Ser Thr Phe Gln Gly  Ile Gln Arg Ala Ala  Glu Ser Thr 
    3575                 3580                 3585             


Glu Glu  Val Ser Ser Leu Arg  Pro Pro Arg Leu Ile  His Glu Asp 
    3590                 3595                 3600             


Gly Ile  Ile Arg Pro Tyr Asp  Arg Gln Glu Ser Glu  Gly Ser Asp 
    3605                 3610                 3615             


Leu Leu  Glu Asn His Ile Lys  Lys Leu Glu Gly Glu  Thr Tyr Arg 
    3620                 3625                 3630             


Tyr His  Cys Ala Ile Pro Gly  Ser Lys Lys Thr Ile  Leu Met Val 
    3635                 3640                 3645             


Thr Asn  Arg Arg Val Leu Cys  Ile Lys Glu Val Glu  Ile Leu Gly 
    3650                 3655                 3660             


Leu Met  Cys Val Asp Trp Gln  Cys Pro Phe Glu Asp  Phe Val Phe 
    3665                 3670                 3675             


Pro Pro  Ser Val Ser Glu Asn  Val Leu Lys Ile Ser  Val Lys Glu 
    3680                 3685                 3690             


Gln Gly  Leu Phe His Lys Lys  Asp Ser Ala Asn Gln  Gly Cys Val 
    3695                 3700                 3705             


Arg Lys  Val Tyr Leu Lys Asp  Thr Ala Thr Ala Glu  Arg Ala Cys 
    3710                 3715                 3720             


Asn Ala  Ile Glu Asp Ala Gln  Ser Thr Arg Gln Gln  Gln Lys Leu 
    3725                 3730                 3735             


Met Lys  Gln Ser Ser Val Arg  Leu Leu Arg Pro Gln  Leu Pro Ser 
    3740                 3745                 3750             


<210>  71
<211>  326
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q15717
<309>  2016-09-07
<313>  (1)..(326)

<400>  71

Met Ser Asn Gly Tyr Glu Asp His Met Ala Glu Asp Cys Arg Gly Asp 
1               5                   10                  15      


Ile Gly Arg Thr Asn Leu Ile Val Asn Tyr Leu Pro Gln Asn Met Thr 
            20                  25                  30          


Gln Asp Glu Leu Arg Ser Leu Phe Ser Ser Ile Gly Glu Val Glu Ser 
        35                  40                  45              


Ala Lys Leu Ile Arg Asp Lys Val Ala Gly His Ser Leu Gly Tyr Gly 
    50                  55                  60                  


Phe Val Asn Tyr Val Thr Ala Lys Asp Ala Glu Arg Ala Ile Asn Thr 
65                  70                  75                  80  


Leu Asn Gly Leu Arg Leu Gln Ser Lys Thr Ile Lys Val Ser Tyr Ala 
                85                  90                  95      


Arg Pro Ser Ser Glu Val Ile Lys Asp Ala Asn Leu Tyr Ile Ser Gly 
            100                 105                 110         


Leu Pro Arg Thr Met Thr Gln Lys Asp Val Glu Asp Met Phe Ser Arg 
        115                 120                 125             


Phe Gly Arg Ile Ile Asn Ser Arg Val Leu Val Asp Gln Thr Thr Gly 
    130                 135                 140                 


Leu Ser Arg Gly Val Ala Phe Ile Arg Phe Asp Lys Arg Ser Glu Ala 
145                 150                 155                 160 


Glu Glu Ala Ile Thr Ser Phe Asn Gly His Lys Pro Pro Gly Ser Ser 
                165                 170                 175     


Glu Pro Ile Thr Val Lys Phe Ala Ala Asn Pro Asn Gln Asn Lys Asn 
            180                 185                 190         


Val Ala Leu Leu Ser Gln Leu Tyr His Ser Pro Ala Arg Arg Phe Gly 
        195                 200                 205             


Gly Pro Val His His Gln Ala Gln Arg Phe Arg Phe Ser Pro Met Gly 
    210                 215                 220                 


Val Asp His Met Ser Gly Leu Ser Gly Val Asn Val Pro Gly Asn Ala 
225                 230                 235                 240 


Ser Ser Gly Trp Cys Ile Phe Ile Tyr Asn Leu Gly Gln Asp Ala Asp 
                245                 250                 255     


Glu Gly Ile Leu Trp Gln Met Phe Gly Pro Phe Gly Ala Val Thr Asn 
            260                 265                 270         


Val Lys Val Ile Arg Asp Phe Asn Thr Asn Lys Cys Lys Gly Phe Gly 
        275                 280                 285             


Phe Val Thr Met Thr Asn Tyr Glu Glu Ala Ala Met Ala Ile Ala Ser 
    290                 295                 300                 


Leu Asn Gly Tyr Arg Leu Gly Asp Lys Ile Leu Gln Val Ser Phe Lys 
305                 310                 315                 320 


Thr Asn Lys Ser His Lys 
                325     


<210>  72
<211>  375
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P60709
<309>  2016-09-07
<313>  (1)..(375)

<400>  72

Met Asp Asp Asp Ile Ala Ala Leu Val Val Asp Asn Gly Ser Gly Met 
1               5                   10                  15      


Cys Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val Phe Pro 
            20                  25                  30          


Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly Met Gly 
        35                  40                  45              


Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg Gly Ile 
    50                  55                  60                  


Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Val Thr Asn Trp Asp 
65                  70                  75                  80  


Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu Arg Val 
                85                  90                  95      


Ala Pro Glu Glu His Pro Val Leu Leu Thr Glu Ala Pro Leu Asn Pro 
            100                 105                 110         


Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr Phe Asn 
        115                 120                 125             


Thr Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu Tyr Ala 
    130                 135                 140                 


Ser Gly Arg Thr Thr Gly Ile Val Met Asp Ser Gly Asp Gly Val Thr 
145                 150                 155                 160 


His Thr Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala Ile Leu 
                165                 170                 175     


Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met Lys Ile 
            180                 185                 190         


Leu Thr Glu Arg Gly Tyr Ser Phe Thr Thr Thr Ala Glu Arg Glu Ile 
        195                 200                 205             


Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp Phe Glu 
    210                 215                 220                 


Gln Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys Ser Tyr 
225                 230                 235                 240 


Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg Phe Arg 
                245                 250                 255     


Cys Pro Glu Ala Leu Phe Gln Pro Ser Phe Leu Gly Met Glu Ser Cys 
            260                 265                 270         


Gly Ile His Glu Thr Thr Phe Asn Ser Ile Met Lys Cys Asp Val Asp 
        275                 280                 285             


Ile Arg Lys Asp Leu Tyr Ala Asn Thr Val Leu Ser Gly Gly Thr Thr 
    290                 295                 300                 


Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr Ala Leu 
305                 310                 315                 320 


Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu Arg Lys 
                325                 330                 335     


Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser Thr Phe 
            340                 345                 350         


Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ser Gly Pro Ser 
        355                 360                 365             


Ile Val His Arg Lys Cys Phe 
    370                 375 


<210>  73
<211>  286
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P60174
<309>  2016-09-07
<313>  (1)..(286)

<400>  73

Met Ala Glu Asp Gly Glu Glu Ala Glu Phe His Phe Ala Ala Leu Tyr 
1               5                   10                  15      


Ile Ser Gly Gln Trp Pro Arg Leu Arg Ala Asp Thr Asp Leu Gln Arg 
            20                  25                  30          


Leu Gly Ser Ser Ala Met Ala Pro Ser Arg Lys Phe Phe Val Gly Gly 
        35                  40                  45              


Asn Trp Lys Met Asn Gly Arg Lys Gln Ser Leu Gly Glu Leu Ile Gly 
    50                  55                  60                  


Thr Leu Asn Ala Ala Lys Val Pro Ala Asp Thr Glu Val Val Cys Ala 
65                  70                  75                  80  


Pro Pro Thr Ala Tyr Ile Asp Phe Ala Arg Gln Lys Leu Asp Pro Lys 
                85                  90                  95      


Ile Ala Val Ala Ala Gln Asn Cys Tyr Lys Val Thr Asn Gly Ala Phe 
            100                 105                 110         


Thr Gly Glu Ile Ser Pro Gly Met Ile Lys Asp Cys Gly Ala Thr Trp 
        115                 120                 125             


Val Val Leu Gly His Ser Glu Arg Arg His Val Phe Gly Glu Ser Asp 
    130                 135                 140                 


Glu Leu Ile Gly Gln Lys Val Ala His Ala Leu Ala Glu Gly Leu Gly 
145                 150                 155                 160 


Val Ile Ala Cys Ile Gly Glu Lys Leu Asp Glu Arg Glu Ala Gly Ile 
                165                 170                 175     


Thr Glu Lys Val Val Phe Glu Gln Thr Lys Val Ile Ala Asp Asn Val 
            180                 185                 190         


Lys Asp Trp Ser Lys Val Val Leu Ala Tyr Glu Pro Val Trp Ala Ile 
        195                 200                 205             


Gly Thr Gly Lys Thr Ala Thr Pro Gln Gln Ala Gln Glu Val His Glu 
    210                 215                 220                 


Lys Leu Arg Gly Trp Leu Lys Ser Asn Val Ser Asp Ala Val Ala Gln 
225                 230                 235                 240 


Ser Thr Arg Ile Ile Tyr Gly Gly Ser Val Thr Gly Ala Thr Cys Lys 
                245                 250                 255     


Glu Leu Ala Ser Gln Pro Asp Val Asp Gly Phe Leu Val Gly Gly Ala 
            260                 265                 270         


Ser Leu Lys Pro Glu Phe Val Asp Ile Ile Asn Ala Lys Gln 
        275                 280                 285     


<210>  74
<211>  427
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UnitProt / O00148
<309>  2005-03-15
<313>  (1)..(427)

<400>  74

Met Ala Glu Gln Asp Val Glu Asn Asp Leu Leu Asp Tyr Asp Glu Glu 
1               5                   10                  15      


Glu Glu Pro Gln Ala Pro Gln Glu Ser Thr Pro Ala Pro Pro Lys Lys 
            20                  25                  30          


Asp Ile Lys Gly Ser Tyr Val Ser Ile His Ser Ser Gly Phe Arg Asp 
        35                  40                  45              


Phe Leu Leu Lys Pro Glu Leu Leu Arg Ala Ile Val Asp Cys Gly Phe 
    50                  55                  60                  


Glu His Pro Ser Glu Val Gln His Glu Cys Ile Pro Gln Ala Ile Leu 
65                  70                  75                  80  


Gly Met Asp Val Leu Cys Gln Ala Lys Ser Gly Met Gly Lys Thr Ala 
                85                  90                  95      


Val Phe Val Leu Ala Thr Leu Gln Gln Ile Glu Pro Val Asn Gly Gln 
            100                 105                 110         


Val Thr Val Leu Val Met Cys His Thr Arg Glu Leu Ala Phe Gln Ile 
        115                 120                 125             


Ser Lys Glu Tyr Glu Arg Phe Ser Lys Tyr Met Pro Ser Val Lys Val 
    130                 135                 140                 


Ser Val Phe Phe Gly Gly Leu Ser Ile Lys Lys Asp Glu Glu Val Leu 
145                 150                 155                 160 


Lys Lys Asn Cys Pro His Val Val Val Gly Thr Pro Gly Arg Ile Leu 
                165                 170                 175     


Ala Leu Val Arg Asn Arg Ser Phe Ser Leu Lys Asn Val Lys His Phe 
            180                 185                 190         


Val Leu Asp Glu Cys Asp Lys Met Leu Glu Gln Leu Asp Met Arg Arg 
        195                 200                 205             


Asp Val Gln Glu Ile Phe Arg Leu Thr Pro His Glu Lys Gln Cys Met 
    210                 215                 220                 


Met Phe Ser Ala Thr Leu Ser Lys Asp Ile Arg Pro Val Cys Arg Lys 
225                 230                 235                 240 


Phe Met Gln Asp Pro Met Glu Val Phe Val Asp Asp Glu Thr Lys Leu 
                245                 250                 255     


Thr Leu His Gly Leu Gln Gln Tyr Tyr Val Lys Leu Lys Asp Ser Glu 
            260                 265                 270         


Lys Asn Arg Lys Leu Phe Asp Leu Leu Asp Val Leu Glu Phe Asn Gln 
        275                 280                 285             


Val Ile Ile Phe Val Lys Ser Val Gln Arg Cys Met Ala Leu Ala Gln 
    290                 295                 300                 


Leu Leu Val Glu Gln Asn Phe Pro Ala Ile Ala Ile His Arg Gly Met 
305                 310                 315                 320 


Ala Gln Glu Glu Arg Leu Ser Arg Tyr Gln Gln Phe Lys Asp Phe Gln 
                325                 330                 335     


Arg Arg Ile Leu Val Ala Thr Asn Leu Phe Gly Arg Gly Met Asp Ile 
            340                 345                 350         


Glu Arg Val Asn Ile Val Phe Asn Tyr Asp Met Pro Glu Asp Ser Asp 
        355                 360                 365             


Thr Tyr Leu His Arg Val Ala Arg Ala Gly Arg Phe Gly Thr Lys Gly 
    370                 375                 380                 


Leu Ala Ile Thr Phe Val Ser Asp Glu Asn Asp Ala Lys Ile Leu Asn 
385                 390                 395                 400 


Asp Val Gln Asp Arg Phe Glu Val Asn Val Ala Glu Leu Pro Glu Glu 
                405                 410                 415     


Ile Asp Ile Ser Thr Tyr Ile Glu Gln Ser Arg 
            420                 425         


<210>  75
<211>  606
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9UNF1
<309>  2016-09-07
<313>  (1)..(606)

<400>  75

Met Ser Asp Thr Ser Glu Ser Gly Ala Gly Leu Thr Arg Phe Gln Ala 
1               5                   10                  15      


Glu Ala Ser Glu Lys Asp Ser Ser Ser Met Met Gln Thr Leu Leu Thr 
            20                  25                  30          


Val Thr Gln Asn Val Glu Val Pro Glu Thr Pro Lys Ala Ser Lys Ala 
        35                  40                  45              


Leu Glu Val Ser Glu Asp Val Lys Val Ser Lys Ala Ser Gly Val Ser 
    50                  55                  60                  


Lys Ala Thr Glu Val Ser Lys Thr Pro Glu Ala Arg Glu Ala Pro Ala 
65                  70                  75                  80  


Thr Gln Ala Ser Ser Thr Thr Gln Leu Thr Asp Thr Gln Val Leu Ala 
                85                  90                  95      


Ala Glu Asn Lys Ser Leu Ala Ala Asp Thr Lys Lys Gln Asn Ala Asp 
            100                 105                 110         


Pro Gln Ala Val Thr Met Pro Ala Thr Glu Thr Lys Lys Val Ser His 
        115                 120                 125             


Val Ala Asp Thr Lys Val Asn Thr Lys Ala Gln Glu Thr Glu Ala Ala 
    130                 135                 140                 


Pro Ser Gln Ala Pro Ala Asp Glu Pro Glu Pro Glu Ser Ala Ala Ala 
145                 150                 155                 160 


Gln Ser Gln Glu Asn Gln Asp Thr Arg Pro Lys Val Lys Ala Lys Lys 
                165                 170                 175     


Ala Arg Lys Val Lys His Leu Asp Gly Glu Glu Asp Gly Ser Ser Asp 
            180                 185                 190         


Gln Ser Gln Ala Ser Gly Thr Thr Gly Gly Arg Arg Val Ser Lys Ala 
        195                 200                 205             


Leu Met Ala Ser Met Ala Arg Arg Ala Ser Arg Gly Pro Ile Ala Phe 
    210                 215                 220                 


Trp Ala Arg Arg Ala Ser Arg Thr Arg Leu Ala Ala Trp Ala Arg Arg 
225                 230                 235                 240 


Ala Leu Leu Ser Leu Arg Ser Pro Lys Ala Arg Arg Gly Lys Ala Arg 
                245                 250                 255     


Arg Arg Ala Ala Lys Leu Gln Ser Ser Gln Glu Pro Glu Ala Pro Pro 
            260                 265                 270         


Pro Arg Asp Val Ala Leu Leu Gln Gly Arg Ala Asn Asp Leu Val Lys 
        275                 280                 285             


Tyr Leu Leu Ala Lys Asp Gln Thr Lys Ile Pro Ile Lys Arg Ser Asp 
    290                 295                 300                 


Met Leu Lys Asp Ile Ile Lys Glu Tyr Thr Asp Val Tyr Pro Glu Ile 
305                 310                 315                 320 


Ile Glu Arg Ala Gly Tyr Ser Leu Glu Lys Val Phe Gly Ile Gln Leu 
                325                 330                 335     


Lys Glu Ile Asp Lys Asn Asp His Leu Tyr Ile Leu Leu Ser Thr Leu 
            340                 345                 350         


Glu Pro Thr Asp Ala Gly Ile Leu Gly Thr Thr Lys Asp Ser Pro Lys 
        355                 360                 365             


Leu Gly Leu Leu Met Val Leu Leu Ser Ile Ile Phe Met Asn Gly Asn 
    370                 375                 380                 


Arg Ser Ser Glu Ala Val Ile Trp Glu Val Leu Arg Lys Leu Gly Leu 
385                 390                 395                 400 


Arg Pro Gly Ile His His Ser Leu Phe Gly Asp Val Lys Lys Leu Ile 
                405                 410                 415     


Thr Asp Glu Phe Val Lys Gln Lys Tyr Leu Asp Tyr Ala Arg Val Pro 
            420                 425                 430         


Asn Ser Asn Pro Pro Glu Tyr Glu Phe Phe Trp Gly Leu Arg Ser Tyr 
        435                 440                 445             


Tyr Glu Thr Ser Lys Met Lys Val Leu Lys Phe Ala Cys Lys Val Gln 
    450                 455                 460                 


Lys Lys Asp Pro Lys Glu Trp Ala Ala Gln Tyr Arg Glu Ala Met Glu 
465                 470                 475                 480 


Ala Asp Leu Lys Ala Ala Ala Glu Ala Ala Ala Glu Ala Lys Ala Arg 
                485                 490                 495     


Ala Glu Ile Arg Ala Arg Met Gly Ile Gly Leu Gly Ser Glu Asn Ala 
            500                 505                 510         


Ala Gly Pro Cys Asn Trp Asp Glu Ala Asp Ile Gly Pro Trp Ala Lys 
        515                 520                 525             


Ala Arg Ile Gln Ala Gly Ala Glu Ala Lys Ala Lys Ala Gln Glu Ser 
    530                 535                 540                 


Gly Ser Ala Ser Thr Gly Ala Ser Thr Ser Thr Asn Asn Ser Ala Ser 
545                 550                 555                 560 


Ala Ser Ala Ser Thr Ser Gly Gly Phe Ser Ala Gly Ala Ser Leu Thr 
                565                 570                 575     


Ala Thr Leu Thr Phe Gly Leu Phe Ala Gly Leu Gly Gly Ala Gly Ala 
            580                 585                 590         


Ser Thr Ser Gly Ser Ser Gly Ala Cys Gly Phe Ser Tyr Lys 
        595                 600                 605     


<210>  76
<211>  196
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P84098
<309>  2016-09-07
<313>  (1)..(196)

<400>  76

Met Ser Met Leu Arg Leu Gln Lys Arg Leu Ala Ser Ser Val Leu Arg 
1               5                   10                  15      


Cys Gly Lys Lys Lys Val Trp Leu Asp Pro Asn Glu Thr Asn Glu Ile 
            20                  25                  30          


Ala Asn Ala Asn Ser Arg Gln Gln Ile Arg Lys Leu Ile Lys Asp Gly 
        35                  40                  45              


Leu Ile Ile Arg Lys Pro Val Thr Val His Ser Arg Ala Arg Cys Arg 
    50                  55                  60                  


Lys Asn Thr Leu Ala Arg Arg Lys Gly Arg His Met Gly Ile Gly Lys 
65                  70                  75                  80  


Arg Lys Gly Thr Ala Asn Ala Arg Met Pro Glu Lys Val Thr Trp Met 
                85                  90                  95      


Arg Arg Met Arg Ile Leu Arg Arg Leu Leu Arg Arg Tyr Arg Glu Ser 
            100                 105                 110         


Lys Lys Ile Asp Arg His Met Tyr His Ser Leu Tyr Leu Lys Val Lys 
        115                 120                 125             


Gly Asn Val Phe Lys Asn Lys Arg Ile Leu Met Glu His Ile His Lys 
    130                 135                 140                 


Leu Lys Ala Asp Lys Ala Arg Lys Lys Leu Leu Ala Asp Gln Ala Glu 
145                 150                 155                 160 


Ala Arg Arg Ser Lys Thr Lys Glu Ala Arg Lys Arg Arg Glu Glu Arg 
                165                 170                 175     


Leu Gln Ala Lys Lys Glu Glu Ile Ile Lys Thr Leu Ser Lys Glu Glu 
            180                 185                 190         


Glu Thr Lys Lys 
        195     


<210>  77
<211>  115
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P05387
<309>  1993-04-24
<313>  (1)..(115)

<400>  77

Met Arg Tyr Val Ala Ser Tyr Leu Leu Ala Ala Leu Gly Gly Asn Ser 
1               5                   10                  15      


Ser Pro Ser Ala Lys Asp Ile Lys Lys Ile Leu Asp Ser Val Gly Ile 
            20                  25                  30          


Glu Ala Asp Asp Asp Arg Leu Asn Lys Val Ile Ser Glu Leu Asn Gly 
        35                  40                  45              


Lys Asn Ile Glu Asp Val Ile Ala Gln Gly Ile Gly Lys Leu Ala Ser 
    50                  55                  60                  


Val Pro Ala Gly Gly Ala Val Ala Val Ser Ala Ala Pro Gly Ser Ala 
65                  70                  75                  80  


Ala Pro Ala Ala Gly Ser Ala Pro Ala Ala Ala Glu Glu Lys Lys Asp 
                85                  90                  95      


Glu Lys Lys Glu Glu Ser Glu Glu Ser Asp Asp Asp Met Gly Phe Gly 
            100                 105                 110         


Leu Phe Asp 
        115 


<210>  78
<211>  221
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q01130
<309>  2016-09-07
<313>  (1)..(221)

<400>  78

Met Ser Tyr Gly Arg Pro Pro Pro Asp Val Glu Gly Met Thr Ser Leu 
1               5                   10                  15      


Lys Val Asp Asn Leu Thr Tyr Arg Thr Ser Pro Asp Thr Leu Arg Arg 
            20                  25                  30          


Val Phe Glu Lys Tyr Gly Arg Val Gly Asp Val Tyr Ile Pro Arg Asp 
        35                  40                  45              


Arg Tyr Thr Lys Glu Ser Arg Gly Phe Ala Phe Val Arg Phe His Asp 
    50                  55                  60                  


Lys Arg Asp Ala Glu Asp Ala Met Asp Ala Met Asp Gly Ala Val Leu 
65                  70                  75                  80  


Asp Gly Arg Glu Leu Arg Val Gln Met Ala Arg Tyr Gly Arg Pro Pro 
                85                  90                  95      


Asp Ser His His Ser Arg Arg Gly Pro Pro Pro Arg Arg Tyr Gly Gly 
            100                 105                 110         


Gly Gly Tyr Gly Arg Arg Ser Arg Ser Pro Arg Arg Arg Arg Arg Ser 
        115                 120                 125             


Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Tyr 
    130                 135                 140                 


Ser Arg Ser Lys Ser Arg Ser Arg Thr Arg Ser Arg Ser Arg Ser Thr 
145                 150                 155                 160 


Ser Lys Ser Arg Ser Ala Arg Arg Ser Lys Ser Lys Ser Ser Ser Val 
                165                 170                 175     


Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Pro 
            180                 185                 190         


Pro Pro Val Ser Lys Arg Glu Ser Lys Ser Arg Ser Arg Ser Lys Ser 
        195                 200                 205             


Pro Pro Lys Ser Pro Glu Glu Glu Gly Ala Val Ser Ser 
    210                 215                 220     


<210>  79
<211>  229
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9H7E9
<309>  2016-09-07
<313>  (1)..(229)

<400>  79

Met Ala Ala Leu Gly His Leu Ala Gly Glu Ala Ala Ala Ala Pro Gly 
1               5                   10                  15      


Pro Gly Thr Pro Cys Ala Ser Arg Gly Ala Arg Leu Pro Gly Pro Val 
            20                  25                  30          


Ser Ser Ala Arg Asn Pro Ser Thr Val Cys Leu Cys Pro Glu Gln Pro 
        35                  40                  45              


Thr Cys Ser Asn Ala Asp Ser Arg Ala His Pro Leu Gly Asp Glu Gly 
    50                  55                  60                  


Gly Thr Ala Ser Lys Lys Gln Lys Asn Lys Lys Lys Thr Arg Asn Arg 
65                  70                  75                  80  


Ala Ser Val Ala Asn Gly Gly Glu Lys Ala Ser Glu Lys Leu Ala Pro 
                85                  90                  95      


Glu Glu Val Pro Leu Ser Ala Glu Ala Gln Ala Gln Gln Leu Ala Gln 
            100                 105                 110         


Glu Leu Ala Trp Cys Val Glu Gln Leu Glu Leu Gly Leu Lys Arg Gln 
        115                 120                 125             


Lys Pro Thr Pro Lys Gln Lys Glu Gln Ala Ile Gly Ala Ile Arg Thr 
    130                 135                 140                 


Leu Arg Ser Lys Arg Thr Pro Leu Pro Arg Lys Arg Gln Leu Met His 
145                 150                 155                 160 


Ser Leu Phe Gly Asp Tyr Arg Ala Gln Met Glu Ala Glu Trp Arg Glu 
                165                 170                 175     


Ala Leu Arg Ala Leu Arg Ala Ala Ala Tyr Ser Ala Gln Val Gln Pro 
            180                 185                 190         


Val Asp Gly Ala Thr Arg Lys Lys Ser Gln Arg Val Cys Arg Pro Arg 
        195                 200                 205             


Ser Ile Trp Arg Ala Lys Ala Thr Leu Asp Met Pro Asp Glu Glu Phe 
    210                 215                 220                 


Arg Phe Asn Phe Phe 
225                 


<210>  80
<211>  730
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P52272
<309>  2016-09-07
<313>  (1)..(730)

<400>  80

Met Ala Ala Gly Val Glu Ala Ala Ala Glu Val Ala Ala Thr Glu Ile 
1               5                   10                  15      


Lys Met Glu Glu Glu Ser Gly Ala Pro Gly Val Pro Ser Gly Asn Gly 
            20                  25                  30          


Ala Pro Gly Pro Lys Gly Glu Gly Glu Arg Pro Ala Gln Asn Glu Lys 
        35                  40                  45              


Arg Lys Glu Lys Asn Ile Lys Arg Gly Gly Asn Arg Phe Glu Pro Tyr 
    50                  55                  60                  


Ala Asn Pro Thr Lys Arg Tyr Arg Ala Phe Ile Thr Asn Ile Pro Phe 
65                  70                  75                  80  


Asp Val Lys Trp Gln Ser Leu Lys Asp Leu Val Lys Glu Lys Val Gly 
                85                  90                  95      


Glu Val Thr Tyr Val Glu Leu Leu Met Asp Ala Glu Gly Lys Ser Arg 
            100                 105                 110         


Gly Cys Ala Val Val Glu Phe Lys Met Glu Glu Ser Met Lys Lys Ala 
        115                 120                 125             


Ala Glu Val Leu Asn Lys His Ser Leu Ser Gly Arg Pro Leu Lys Val 
    130                 135                 140                 


Lys Glu Asp Pro Asp Gly Glu His Ala Arg Arg Ala Met Gln Lys Val 
145                 150                 155                 160 


Met Ala Thr Thr Gly Gly Met Gly Met Gly Pro Gly Gly Pro Gly Met 
                165                 170                 175     


Ile Thr Ile Pro Pro Ser Ile Leu Asn Asn Pro Asn Ile Pro Asn Glu 
            180                 185                 190         


Ile Ile His Ala Leu Gln Ala Gly Arg Leu Gly Ser Thr Val Phe Val 
        195                 200                 205             


Ala Asn Leu Asp Tyr Lys Val Gly Trp Lys Lys Leu Lys Glu Val Phe 
    210                 215                 220                 


Ser Met Ala Gly Val Val Val Arg Ala Asp Ile Leu Glu Asp Lys Asp 
225                 230                 235                 240 


Gly Lys Ser Arg Gly Ile Gly Thr Val Thr Phe Glu Gln Ser Ile Glu 
                245                 250                 255     


Ala Val Gln Ala Ile Ser Met Phe Asn Gly Gln Leu Leu Phe Asp Arg 
            260                 265                 270         


Pro Met His Val Lys Met Asp Glu Arg Ala Leu Pro Lys Gly Asp Phe 
        275                 280                 285             


Phe Pro Pro Glu Arg Pro Gln Gln Leu Pro His Gly Leu Gly Gly Ile 
    290                 295                 300                 


Gly Met Gly Leu Gly Pro Gly Gly Gln Pro Ile Asp Ala Asn His Leu 
305                 310                 315                 320 


Asn Lys Gly Ile Gly Met Gly Asn Ile Gly Pro Ala Gly Met Gly Met 
                325                 330                 335     


Glu Gly Ile Gly Phe Gly Ile Asn Lys Met Gly Gly Met Glu Gly Pro 
            340                 345                 350         


Phe Gly Gly Gly Met Glu Asn Met Gly Arg Phe Gly Ser Gly Met Asn 
        355                 360                 365             


Met Gly Arg Ile Asn Glu Ile Leu Ser Asn Ala Leu Lys Arg Gly Glu 
    370                 375                 380                 


Ile Ile Ala Lys Gln Gly Gly Gly Gly Gly Gly Gly Ser Val Pro Gly 
385                 390                 395                 400 


Ile Glu Arg Met Gly Pro Gly Ile Asp Arg Leu Gly Gly Ala Gly Met 
                405                 410                 415     


Glu Arg Met Gly Ala Gly Leu Gly His Gly Met Asp Arg Val Gly Ser 
            420                 425                 430         


Glu Ile Glu Arg Met Gly Leu Val Met Asp Arg Met Gly Ser Val Glu 
        435                 440                 445             


Arg Met Gly Ser Gly Ile Glu Arg Met Gly Pro Leu Gly Leu Asp His 
    450                 455                 460                 


Met Ala Ser Ser Ile Glu Arg Met Gly Gln Thr Met Glu Arg Ile Gly 
465                 470                 475                 480 


Ser Gly Val Glu Arg Met Gly Ala Gly Met Gly Phe Gly Leu Glu Arg 
                485                 490                 495     


Met Ala Ala Pro Ile Asp Arg Val Gly Gln Thr Ile Glu Arg Met Gly 
            500                 505                 510         


Ser Gly Val Glu Arg Met Gly Pro Ala Ile Glu Arg Met Gly Leu Ser 
        515                 520                 525             


Met Glu Arg Met Val Pro Ala Gly Met Gly Ala Gly Leu Glu Arg Met 
    530                 535                 540                 


Gly Pro Val Met Asp Arg Met Ala Thr Gly Leu Glu Arg Met Gly Ala 
545                 550                 555                 560 


Asn Asn Leu Glu Arg Met Gly Leu Glu Arg Met Gly Ala Asn Ser Leu 
                565                 570                 575     


Glu Arg Met Gly Leu Glu Arg Met Gly Ala Asn Ser Leu Glu Arg Met 
            580                 585                 590         


Gly Pro Ala Met Gly Pro Ala Leu Gly Ala Gly Ile Glu Arg Met Gly 
        595                 600                 605             


Leu Ala Met Gly Gly Gly Gly Gly Ala Ser Phe Asp Arg Ala Ile Glu 
    610                 615                 620                 


Met Glu Arg Gly Asn Phe Gly Gly Ser Phe Ala Gly Ser Phe Gly Gly 
625                 630                 635                 640 


Ala Gly Gly His Ala Pro Gly Val Ala Arg Lys Ala Cys Gln Ile Phe 
                645                 650                 655     


Val Arg Asn Leu Pro Phe Asp Phe Thr Trp Lys Met Leu Lys Asp Lys 
            660                 665                 670         


Phe Asn Glu Cys Gly His Val Leu Tyr Ala Asp Ile Lys Met Glu Asn 
        675                 680                 685             


Gly Lys Ser Lys Gly Cys Gly Val Val Lys Phe Glu Ser Pro Glu Val 
    690                 695                 700                 


Ala Glu Arg Ala Cys Arg Met Met Asn Gly Met Lys Leu Ser Gly Arg 
705                 710                 715                 720 


Glu Ile Asp Val Arg Ile Asp Arg Asn Ala 
                725                 730 


<210>  81
<211>  119
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P62314
<309>  2016-09-07
<313>  (1)..(119)

<400>  81

Met Lys Leu Val Arg Phe Leu Met Lys Leu Ser His Glu Thr Val Thr 
1               5                   10                  15      


Ile Glu Leu Lys Asn Gly Thr Gln Val His Gly Thr Ile Thr Gly Val 
            20                  25                  30          


Asp Val Ser Met Asn Thr His Leu Lys Ala Val Lys Met Thr Leu Lys 
        35                  40                  45              


Asn Arg Glu Pro Val Gln Leu Glu Thr Leu Ser Ile Arg Gly Asn Asn 
    50                  55                  60                  


Ile Arg Tyr Phe Ile Leu Pro Asp Ser Leu Pro Leu Asp Thr Leu Leu 
65                  70                  75                  80  


Val Asp Val Glu Pro Lys Val Lys Ser Lys Lys Arg Glu Ala Val Ala 
                85                  90                  95      


Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg 
            100                 105                 110         


Gly Arg Gly Gly Pro Arg Arg 
        115                 


<210>  82
<211>  483
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P26196
<309>  1993-04-24
<313>  (1)..(483)

<400>  82

Met Ser Thr Ala Arg Thr Glu Asn Pro Val Ile Met Gly Leu Ser Ser 
1               5                   10                  15      


Gln Asn Gly Gln Leu Arg Gly Pro Val Lys Pro Thr Gly Gly Pro Gly 
            20                  25                  30          


Gly Gly Gly Thr Gln Thr Gln Gln Gln Met Asn Gln Leu Lys Asn Thr 
        35                  40                  45              


Asn Thr Ile Asn Asn Gly Thr Gln Gln Gln Ala Gln Ser Met Thr Thr 
    50                  55                  60                  


Thr Ile Lys Pro Gly Asp Asp Trp Lys Lys Thr Leu Lys Leu Pro Pro 
65                  70                  75                  80  


Lys Asp Leu Arg Ile Lys Thr Ser Asp Val Thr Ser Thr Lys Gly Asn 
                85                  90                  95      


Glu Phe Glu Asp Tyr Cys Leu Lys Arg Glu Leu Leu Met Gly Ile Phe 
            100                 105                 110         


Glu Met Gly Trp Glu Lys Pro Ser Pro Ile Gln Glu Glu Ser Ile Pro 
        115                 120                 125             


Ile Ala Leu Ser Gly Arg Asp Ile Leu Ala Arg Ala Lys Asn Gly Thr 
    130                 135                 140                 


Gly Lys Ser Gly Ala Tyr Leu Ile Pro Leu Leu Glu Arg Leu Asp Leu 
145                 150                 155                 160 


Lys Lys Asp Asn Ile Gln Ala Met Val Ile Val Pro Thr Arg Glu Leu 
                165                 170                 175     


Ala Leu Gln Val Ser Gln Ile Cys Ile Gln Val Ser Lys His Met Gly 
            180                 185                 190         


Gly Ala Lys Val Met Ala Thr Thr Gly Gly Thr Asn Leu Arg Asp Asp 
        195                 200                 205             


Ile Met Arg Leu Asp Asp Thr Val His Val Val Ile Ala Thr Pro Gly 
    210                 215                 220                 


Arg Ile Leu Asp Leu Ile Lys Lys Gly Val Ala Lys Val Asp His Val 
225                 230                 235                 240 


Gln Met Ile Val Leu Asp Glu Ala Asp Lys Leu Leu Ser Gln Asp Phe 
                245                 250                 255     


Val Gln Ile Met Glu Asp Ile Ile Leu Thr Leu Pro Lys Asn Arg Gln 
            260                 265                 270         


Ile Leu Leu Tyr Ser Ala Thr Phe Pro Leu Ser Val Gln Lys Phe Met 
        275                 280                 285             


Asn Ser His Leu Gln Lys Pro Tyr Glu Ile Asn Leu Met Glu Glu Leu 
    290                 295                 300                 


Thr Leu Lys Gly Val Thr Gln Tyr Tyr Ala Tyr Val Thr Glu Arg Gln 
305                 310                 315                 320 


Lys Val His Cys Leu Asn Thr Leu Phe Ser Arg Leu Gln Ile Asn Gln 
                325                 330                 335     


Ser Ile Ile Phe Cys Asn Ser Ser Gln Arg Val Glu Leu Leu Ala Lys 
            340                 345                 350         


Lys Ile Ser Gln Leu Gly Tyr Ser Cys Phe Tyr Ile His Ala Lys Met 
        355                 360                 365             


Arg Gln Glu His Arg Asn Arg Val Phe His Asp Phe Arg Asn Gly Leu 
    370                 375                 380                 


Cys Arg Asn Leu Val Cys Thr Asp Leu Phe Thr Arg Gly Ile Asp Ile 
385                 390                 395                 400 


Gln Ala Val Asn Val Val Ile Asn Phe Asp Phe Pro Lys Leu Ala Glu 
                405                 410                 415     


Thr Tyr Leu His Arg Ile Gly Arg Ser Gly Arg Phe Gly His Leu Gly 
            420                 425                 430         


Leu Ala Ile Asn Leu Ile Thr Tyr Asp Asp Arg Phe Asn Leu Lys Ser 
        435                 440                 445             


Ile Glu Glu Gln Leu Gly Thr Glu Ile Lys Pro Ile Pro Ser Asn Ile 
    450                 455                 460                 


Asp Lys Ser Leu Tyr Val Ala Glu Tyr His Ser Glu Pro Val Glu Asp 
465                 470                 475                 480 


Glu Lys Pro 
            


<210>  83
<211>  377
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P68032
<309>  2016-09-07
<313>  (1)..(377)

<400>  83

Met Cys Asp Asp Glu Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
1               5                   10                  15      


Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
            20                  25                  30          


Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
        35                  40                  45              


Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
    50                  55                  60                  


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
65                  70                  75                  80  


Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                85                  90                  95      


Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
            100                 105                 110         


Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
        115                 120                 125             


Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
    130                 135                 140                 


Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
145                 150                 155                 160 


Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                165                 170                 175     


Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
            180                 185                 190         


Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
        195                 200                 205             


Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
    210                 215                 220                 


Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
225                 230                 235                 240 


Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                245                 250                 255     


Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
            260                 265                 270         


Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
        275                 280                 285             


Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Leu Ser Gly Gly 
    290                 295                 300                 


Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
305                 310                 315                 320 


Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                325                 330                 335     


Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
            340                 345                 350         


Thr Phe Gln Gln Met Trp Ile Ser Lys Gln Glu Tyr Asp Glu Ala Gly 
        355                 360                 365             


Pro Ser Ile Val His Arg Lys Cys Phe 
    370                 375         


<210>  84
<211>  391
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P55209
<309>  2016-09-07
<313>  (1)..(391)

<400>  84

Met Ala Asp Ile Asp Asn Lys Glu Gln Ser Glu Leu Asp Gln Asp Leu 
1               5                   10                  15      


Asp Asp Val Glu Glu Val Glu Glu Glu Glu Thr Gly Glu Glu Thr Lys 
            20                  25                  30          


Leu Lys Ala Arg Gln Leu Thr Val Gln Met Met Gln Asn Pro Gln Ile 
        35                  40                  45              


Leu Ala Ala Leu Gln Glu Arg Leu Asp Gly Leu Val Glu Thr Pro Thr 
    50                  55                  60                  


Gly Tyr Ile Glu Ser Leu Pro Arg Val Val Lys Arg Arg Val Asn Ala 
65                  70                  75                  80  


Leu Lys Asn Leu Gln Val Lys Cys Ala Gln Ile Glu Ala Lys Phe Tyr 
                85                  90                  95      


Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala Val Leu Tyr Gln Pro 
            100                 105                 110         


Leu Phe Asp Lys Arg Phe Glu Ile Ile Asn Ala Ile Tyr Glu Pro Thr 
        115                 120                 125             


Glu Glu Glu Cys Glu Trp Lys Pro Asp Glu Glu Asp Glu Ile Ser Glu 
    130                 135                 140                 


Glu Leu Lys Glu Lys Ala Lys Ile Glu Asp Glu Lys Lys Asp Glu Glu 
145                 150                 155                 160 


Lys Glu Asp Pro Lys Gly Ile Pro Glu Phe Trp Leu Thr Val Phe Lys 
                165                 170                 175     


Asn Val Asp Leu Leu Ser Asp Met Val Gln Glu His Asp Glu Pro Ile 
            180                 185                 190         


Leu Lys His Leu Lys Asp Ile Lys Val Lys Phe Ser Asp Ala Gly Gln 
        195                 200                 205             


Pro Met Ser Phe Val Leu Glu Phe His Phe Glu Pro Asn Glu Tyr Phe 
    210                 215                 220                 


Thr Asn Glu Val Leu Thr Lys Thr Tyr Arg Met Arg Ser Glu Pro Asp 
225                 230                 235                 240 


Asp Ser Asp Pro Phe Ser Phe Asp Gly Pro Glu Ile Met Gly Cys Thr 
                245                 250                 255     


Gly Cys Gln Ile Asp Trp Lys Lys Gly Lys Asn Val Thr Leu Lys Thr 
            260                 265                 270         


Ile Lys Lys Lys Gln Lys His Lys Gly Arg Gly Thr Val Arg Thr Val 
        275                 280                 285             


Thr Lys Thr Val Ser Asn Asp Ser Phe Phe Asn Phe Phe Ala Pro Pro 
    290                 295                 300                 


Glu Val Pro Glu Ser Gly Asp Leu Asp Asp Asp Ala Glu Ala Ile Leu 
305                 310                 315                 320 


Ala Ala Asp Phe Glu Ile Gly His Phe Leu Arg Glu Arg Ile Ile Pro 
                325                 330                 335     


Arg Ser Val Leu Tyr Phe Thr Gly Glu Ala Ile Glu Asp Asp Asp Asp 
            340                 345                 350         


Asp Tyr Asp Glu Glu Gly Glu Glu Ala Asp Glu Glu Gly Glu Glu Glu 
        355                 360                 365             


Gly Asp Glu Glu Asn Asp Pro Asp Tyr Asp Pro Lys Lys Asp Gln Asn 
    370                 375                 380                 


Pro Ala Glu Cys Lys Gln Gln 
385                 390     


<210>  85
<211>  365
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q15366
<309>  2016-09-07
<313>  (1)..(365)

<400>  85

Met Asp Thr Gly Val Ile Glu Gly Gly Leu Asn Val Thr Leu Thr Ile 
1               5                   10                  15      


Arg Leu Leu Met His Gly Lys Glu Val Gly Ser Ile Ile Gly Lys Lys 
            20                  25                  30          


Gly Glu Ser Val Lys Lys Met Arg Glu Glu Ser Gly Ala Arg Ile Asn 
        35                  40                  45              


Ile Ser Glu Gly Asn Cys Pro Glu Arg Ile Ile Thr Leu Ala Gly Pro 
    50                  55                  60                  


Thr Asn Ala Ile Phe Lys Ala Phe Ala Met Ile Ile Asp Lys Leu Glu 
65                  70                  75                  80  


Glu Asp Ile Ser Ser Ser Met Thr Asn Ser Thr Ala Ala Ser Arg Pro 
                85                  90                  95      


Pro Val Thr Leu Arg Leu Val Val Pro Ala Ser Gln Cys Gly Ser Leu 
            100                 105                 110         


Ile Gly Lys Gly Gly Cys Lys Ile Lys Glu Ile Arg Glu Ser Thr Gly 
        115                 120                 125             


Ala Gln Val Gln Val Ala Gly Asp Met Leu Pro Asn Ser Thr Glu Arg 
    130                 135                 140                 


Ala Ile Thr Ile Ala Gly Ile Pro Gln Ser Ile Ile Glu Cys Val Lys 
145                 150                 155                 160 


Gln Ile Cys Val Val Met Leu Glu Thr Leu Ser Gln Ser Pro Pro Lys 
                165                 170                 175     


Gly Val Thr Ile Pro Tyr Arg Pro Lys Pro Ser Ser Ser Pro Val Ile 
            180                 185                 190         


Phe Ala Gly Gly Gln Asp Arg Tyr Ser Thr Gly Ser Asp Ser Ala Ser 
        195                 200                 205             


Phe Pro His Thr Thr Pro Ser Met Cys Leu Asn Pro Asp Leu Glu Gly 
    210                 215                 220                 


Pro Pro Leu Glu Ala Tyr Thr Ile Gln Gly Gln Tyr Ala Ile Pro Gln 
225                 230                 235                 240 


Pro Asp Leu Thr Lys Leu His Gln Leu Ala Met Gln Gln Ser His Phe 
                245                 250                 255     


Pro Met Thr His Gly Asn Thr Gly Phe Ser Gly Ile Glu Ser Ser Ser 
            260                 265                 270         


Pro Glu Val Lys Gly Tyr Trp Gly Leu Asp Ala Ser Ala Gln Thr Thr 
        275                 280                 285             


Ser His Glu Leu Thr Ile Pro Asn Asp Leu Ile Gly Cys Ile Ile Gly 
    290                 295                 300                 


Arg Gln Gly Ala Lys Ile Asn Glu Ile Arg Gln Met Ser Gly Ala Gln 
305                 310                 315                 320 


Ile Lys Ile Ala Asn Pro Val Glu Gly Ser Thr Asp Arg Gln Val Thr 
                325                 330                 335     


Ile Thr Gly Ser Ala Ala Ser Ile Ser Leu Ala Gln Tyr Leu Ile Asn 
            340                 345                 350         


Val Arg Leu Ser Ser Glu Thr Gly Gly Met Gly Ser Ser 
        355                 360                 365 


<210>  86
<211>  194
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P62081
<309>  2016-09-07
<313>  (1)..(194)

<400>  86

Met Phe Ser Ser Ser Ala Lys Ile Val Lys Pro Asn Gly Glu Lys Pro 
1               5                   10                  15      


Asp Glu Phe Glu Ser Gly Ile Ser Gln Ala Leu Leu Glu Leu Glu Met 
            20                  25                  30          


Asn Ser Asp Leu Lys Ala Gln Leu Arg Glu Leu Asn Ile Thr Ala Ala 
        35                  40                  45              


Lys Glu Ile Glu Val Gly Gly Gly Arg Lys Ala Ile Ile Ile Phe Val 
    50                  55                  60                  


Pro Val Pro Gln Leu Lys Ser Phe Gln Lys Ile Gln Val Arg Leu Val 
65                  70                  75                  80  


Arg Glu Leu Glu Lys Lys Phe Ser Gly Lys His Val Val Phe Ile Ala 
                85                  90                  95      


Gln Arg Arg Ile Leu Pro Lys Pro Thr Arg Lys Ser Arg Thr Lys Asn 
            100                 105                 110         


Lys Gln Lys Arg Pro Arg Ser Arg Thr Leu Thr Ala Val His Asp Ala 
        115                 120                 125             


Ile Leu Glu Asp Leu Val Phe Pro Ser Glu Ile Val Gly Lys Arg Ile 
    130                 135                 140                 


Arg Val Lys Leu Asp Gly Ser Arg Leu Ile Lys Val His Leu Asp Lys 
145                 150                 155                 160 


Ala Gln Gln Asn Asn Val Glu His Lys Val Glu Thr Phe Ser Gly Val 
                165                 170                 175     


Tyr Lys Lys Leu Thr Gly Lys Asp Val Asn Phe Glu Phe Pro Glu Phe 
            180                 185                 190         


Gln Leu 
        


<210>  87
<211>  614
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P17844
<309>  1993-04-24
<313>  (1)..(614)

<400>  87

Met Ser Gly Tyr Ser Ser Asp Arg Asp Arg Gly Arg Asp Arg Gly Phe 
1               5                   10                  15      


Gly Ala Pro Arg Phe Gly Gly Ser Arg Ala Gly Pro Leu Ser Gly Lys 
            20                  25                  30          


Lys Phe Gly Asn Pro Gly Glu Lys Leu Val Lys Lys Lys Trp Asn Leu 
        35                  40                  45              


Asp Glu Leu Pro Lys Phe Glu Lys Asn Phe Tyr Gln Glu His Pro Asp 
    50                  55                  60                  


Leu Ala Arg Arg Thr Ala Gln Glu Val Glu Thr Tyr Arg Arg Ser Lys 
65                  70                  75                  80  


Glu Ile Thr Val Arg Gly His Asn Cys Pro Lys Pro Val Leu Asn Phe 
                85                  90                  95      


Tyr Glu Ala Asn Phe Pro Ala Asn Val Met Asp Val Ile Ala Arg Gln 
            100                 105                 110         


Asn Phe Thr Glu Pro Thr Ala Ile Gln Ala Gln Gly Trp Pro Val Ala 
        115                 120                 125             


Leu Ser Gly Leu Asp Met Val Gly Val Ala Gln Thr Gly Ser Gly Lys 
    130                 135                 140                 


Thr Leu Ser Tyr Leu Leu Pro Ala Ile Val His Ile Asn His Gln Pro 
145                 150                 155                 160 


Phe Leu Glu Arg Gly Asp Gly Pro Ile Cys Leu Val Leu Ala Pro Thr 
                165                 170                 175     


Arg Glu Leu Ala Gln Gln Val Gln Gln Val Ala Ala Glu Tyr Cys Arg 
            180                 185                 190         


Ala Cys Arg Leu Lys Ser Thr Cys Ile Tyr Gly Gly Ala Pro Lys Gly 
        195                 200                 205             


Pro Gln Ile Arg Asp Leu Glu Arg Gly Val Glu Ile Cys Ile Ala Thr 
    210                 215                 220                 


Pro Gly Arg Leu Ile Asp Phe Leu Glu Cys Gly Lys Thr Asn Leu Arg 
225                 230                 235                 240 


Arg Thr Thr Tyr Leu Val Leu Asp Glu Ala Asp Arg Met Leu Asp Met 
                245                 250                 255     


Gly Phe Glu Pro Gln Ile Arg Lys Ile Val Asp Gln Ile Arg Pro Asp 
            260                 265                 270         


Arg Gln Thr Leu Met Trp Ser Ala Thr Trp Pro Lys Glu Val Arg Gln 
        275                 280                 285             


Leu Ala Glu Asp Phe Leu Lys Asp Tyr Ile His Ile Asn Ile Gly Ala 
    290                 295                 300                 


Leu Glu Leu Ser Ala Asn His Asn Ile Leu Gln Ile Val Asp Val Cys 
305                 310                 315                 320 


His Asp Val Glu Lys Asp Glu Lys Leu Ile Arg Leu Met Glu Glu Ile 
                325                 330                 335     


Met Ser Glu Lys Glu Asn Lys Thr Ile Val Phe Val Glu Thr Lys Arg 
            340                 345                 350         


Arg Cys Asp Glu Leu Thr Arg Lys Met Arg Arg Asp Gly Trp Pro Ala 
        355                 360                 365             


Met Gly Ile His Gly Asp Lys Ser Gln Gln Glu Arg Asp Trp Val Leu 
    370                 375                 380                 


Asn Glu Phe Lys His Gly Lys Ala Pro Ile Leu Ile Ala Thr Asp Val 
385                 390                 395                 400 


Ala Ser Arg Gly Leu Asp Val Glu Asp Val Lys Phe Val Ile Asn Tyr 
                405                 410                 415     


Asp Tyr Pro Asn Ser Ser Glu Asp Tyr Ile His Arg Ile Gly Arg Thr 
            420                 425                 430         


Ala Arg Ser Thr Lys Thr Gly Thr Ala Tyr Thr Phe Phe Thr Pro Asn 
        435                 440                 445             


Asn Ile Lys Gln Val Ser Asp Leu Ile Ser Val Leu Arg Glu Ala Asn 
    450                 455                 460                 


Gln Ala Ile Asn Pro Lys Leu Leu Gln Leu Val Glu Asp Arg Gly Ser 
465                 470                 475                 480 


Gly Arg Ser Arg Gly Arg Gly Gly Met Lys Asp Asp Arg Arg Asp Arg 
                485                 490                 495     


Tyr Ser Ala Gly Lys Arg Gly Gly Phe Asn Thr Phe Arg Asp Arg Glu 
            500                 505                 510         


Asn Tyr Asp Arg Gly Tyr Ser Ser Leu Leu Lys Arg Asp Phe Gly Ala 
        515                 520                 525             


Lys Thr Gln Asn Gly Val Tyr Ser Ala Ala Asn Tyr Thr Asn Gly Ser 
    530                 535                 540                 


Phe Gly Ser Asn Phe Val Ser Ala Gly Ile Gln Thr Ser Phe Arg Thr 
545                 550                 555                 560 


Gly Asn Pro Thr Gly Thr Tyr Gln Asn Gly Tyr Asp Ser Thr Gln Gln 
                565                 570                 575     


Tyr Gly Ser Asn Val Pro Asn Met His Asn Gly Met Asn Gln Gln Ala 
            580                 585                 590         


Tyr Ala Tyr Pro Ala Thr Ala Ala Ala Pro Met Ile Gly Tyr Pro Met 
        595                 600                 605             


Pro Thr Gly Tyr Ser Gln 
    610                 


<210>  88
<211>  207
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P16455
<309>  1993-04-24
<313>  (1)..(207)

<400>  88

Met Asp Lys Asp Cys Glu Met Lys Arg Thr Thr Leu Asp Ser Pro Leu 
1               5                   10                  15      


Gly Lys Leu Glu Leu Ser Gly Cys Glu Gln Gly Leu His Glu Ile Lys 
            20                  25                  30          


Leu Leu Gly Lys Gly Thr Ser Ala Ala Asp Ala Val Glu Val Pro Ala 
        35                  40                  45              


Pro Ala Ala Val Leu Gly Gly Pro Glu Pro Leu Met Gln Cys Thr Ala 
    50                  55                  60                  


Trp Leu Asn Ala Tyr Phe His Gln Pro Glu Ala Ile Glu Glu Phe Pro 
65                  70                  75                  80  


Val Pro Ala Leu His His Pro Val Phe Gln Gln Glu Ser Phe Thr Arg 
                85                  90                  95      


Gln Val Leu Trp Lys Leu Leu Lys Val Val Lys Phe Gly Glu Val Ile 
            100                 105                 110         


Ser Tyr Gln Gln Leu Ala Ala Leu Ala Gly Asn Pro Lys Ala Ala Arg 
        115                 120                 125             


Ala Val Gly Gly Ala Met Arg Gly Asn Pro Val Pro Ile Leu Ile Pro 
    130                 135                 140                 


Cys His Arg Val Val Cys Ser Ser Gly Ala Val Gly Asn Tyr Ser Gly 
145                 150                 155                 160 


Gly Leu Ala Val Lys Glu Trp Leu Leu Ala His Glu Gly His Arg Leu 
                165                 170                 175     


Gly Lys Pro Gly Leu Gly Gly Ser Ser Gly Leu Ala Gly Ala Trp Leu 
            180                 185                 190         


Lys Gly Ala Gly Ala Thr Ser Gly Ser Pro Pro Ala Gly Arg Asn 
        195                 200                 205         


<210>  89
<211>  517
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P35269
<309>  2016-09-07
<313>  (1)..(517)

<400>  89

Met Ala Ala Leu Gly Pro Ser Ser Gln Asn Val Thr Glu Tyr Val Val 
1               5                   10                  15      


Arg Val Pro Lys Asn Thr Thr Lys Lys Tyr Asn Ile Met Ala Phe Asn 
            20                  25                  30          


Ala Ala Asp Lys Val Asn Phe Ala Thr Trp Asn Gln Ala Arg Leu Glu 
        35                  40                  45              


Arg Asp Leu Ser Asn Lys Lys Ile Tyr Gln Glu Glu Glu Met Pro Glu 
    50                  55                  60                  


Ser Gly Ala Gly Ser Glu Phe Asn Arg Lys Leu Arg Glu Glu Ala Arg 
65                  70                  75                  80  


Arg Lys Lys Tyr Gly Ile Val Leu Lys Glu Phe Arg Pro Glu Asp Gln 
                85                  90                  95      


Pro Trp Leu Leu Arg Val Asn Gly Lys Ser Gly Arg Lys Phe Lys Gly 
            100                 105                 110         


Ile Lys Lys Gly Gly Val Thr Glu Asn Thr Ser Tyr Tyr Ile Phe Thr 
        115                 120                 125             


Gln Cys Pro Asp Gly Ala Phe Glu Ala Phe Pro Val His Asn Trp Tyr 
    130                 135                 140                 


Asn Phe Thr Pro Leu Ala Arg His Arg Thr Leu Thr Ala Glu Glu Ala 
145                 150                 155                 160 


Glu Glu Glu Trp Glu Arg Arg Asn Lys Val Leu Asn His Phe Ser Ile 
                165                 170                 175     


Met Gln Gln Arg Arg Leu Lys Asp Gln Asp Gln Asp Glu Asp Glu Glu 
            180                 185                 190         


Glu Lys Glu Lys Arg Gly Arg Arg Lys Ala Ser Glu Leu Arg Ile His 
        195                 200                 205             


Asp Leu Glu Asp Asp Leu Glu Met Ser Ser Asp Ala Ser Asp Ala Ser 
    210                 215                 220                 


Gly Glu Glu Gly Gly Arg Val Pro Lys Ala Lys Lys Lys Ala Pro Leu 
225                 230                 235                 240 


Ala Lys Gly Gly Arg Lys Lys Lys Lys Lys Lys Gly Ser Asp Asp Glu 
                245                 250                 255     


Ala Phe Glu Asp Ser Asp Asp Gly Asp Phe Glu Gly Gln Glu Val Asp 
            260                 265                 270         


Tyr Met Ser Asp Gly Ser Ser Ser Ser Gln Glu Glu Pro Glu Ser Lys 
        275                 280                 285             


Ala Lys Ala Pro Gln Gln Glu Glu Gly Pro Lys Gly Val Asp Glu Gln 
    290                 295                 300                 


Ser Asp Ser Ser Glu Glu Ser Glu Glu Glu Lys Pro Pro Glu Glu Asp 
305                 310                 315                 320 


Lys Glu Glu Glu Glu Glu Lys Lys Ala Pro Thr Pro Gln Glu Lys Lys 
                325                 330                 335     


Arg Arg Lys Asp Ser Ser Glu Glu Ser Asp Ser Ser Glu Glu Ser Asp 
            340                 345                 350         


Ile Asp Ser Glu Ala Ser Ser Ala Leu Phe Met Ala Lys Lys Lys Thr 
        355                 360                 365             


Pro Pro Lys Arg Glu Arg Lys Pro Ser Gly Gly Ser Ser Arg Gly Asn 
    370                 375                 380                 


Ser Arg Pro Gly Thr Pro Ser Ala Glu Gly Gly Ser Thr Ser Ser Thr 
385                 390                 395                 400 


Leu Arg Ala Ala Ala Ser Lys Leu Glu Gln Gly Lys Arg Val Ser Glu 
                405                 410                 415     


Met Pro Ala Ala Lys Arg Leu Arg Leu Asp Thr Gly Pro Gln Ser Leu 
            420                 425                 430         


Ser Gly Lys Ser Thr Pro Gln Pro Pro Ser Gly Lys Thr Thr Pro Asn 
        435                 440                 445             


Ser Gly Asp Val Gln Val Thr Glu Asp Ala Val Arg Arg Tyr Leu Thr 
    450                 455                 460                 


Arg Lys Pro Met Thr Thr Lys Asp Leu Leu Lys Lys Phe Gln Thr Lys 
465                 470                 475                 480 


Lys Thr Gly Leu Ser Ser Glu Gln Thr Val Asn Val Leu Ala Gln Ile 
                485                 490                 495     


Leu Lys Arg Leu Asn Pro Glu Arg Lys Met Ile Asn Asp Lys Met His 
            500                 505                 510         


Phe Ser Leu Lys Glu 
        515         


<210>  90
<211>  248
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q15056
<309>  2016-09-07
<313>  (1)..(248)

<400>  90

Met Ala Asp Phe Asp Thr Tyr Asp Asp Arg Ala Tyr Ser Ser Phe Gly 
1               5                   10                  15      


Gly Gly Arg Gly Ser Arg Gly Ser Ala Gly Gly His Gly Ser Arg Ser 
            20                  25                  30          


Gln Lys Glu Leu Pro Thr Glu Pro Pro Tyr Thr Ala Tyr Val Gly Asn 
        35                  40                  45              


Leu Pro Phe Asn Thr Val Gln Gly Asp Ile Asp Ala Ile Phe Lys Asp 
    50                  55                  60                  


Leu Ser Ile Arg Ser Val Arg Leu Val Arg Asp Lys Asp Thr Asp Lys 
65                  70                  75                  80  


Phe Lys Gly Phe Cys Tyr Val Glu Phe Asp Glu Val Asp Ser Leu Lys 
                85                  90                  95      


Glu Ala Leu Thr Tyr Asp Gly Ala Leu Leu Gly Asp Arg Ser Leu Arg 
            100                 105                 110         


Val Asp Ile Ala Glu Gly Arg Lys Gln Asp Lys Gly Gly Phe Gly Phe 
        115                 120                 125             


Arg Lys Gly Gly Pro Asp Asp Arg Gly Met Gly Ser Ser Arg Glu Ser 
    130                 135                 140                 


Arg Gly Gly Trp Asp Ser Arg Asp Asp Phe Asn Ser Gly Phe Arg Asp 
145                 150                 155                 160 


Asp Phe Leu Gly Gly Arg Gly Gly Ser Arg Pro Gly Asp Arg Arg Thr 
                165                 170                 175     


Gly Pro Pro Met Gly Ser Arg Phe Arg Asp Gly Pro Pro Leu Arg Gly 
            180                 185                 190         


Ser Asn Met Asp Phe Arg Glu Pro Thr Glu Glu Glu Arg Ala Gln Arg 
        195                 200                 205             


Pro Arg Leu Gln Leu Lys Pro Arg Thr Val Ala Thr Pro Leu Asn Gln 
    210                 215                 220                 


Val Ala Asn Pro Asn Ser Ala Ile Phe Gly Gly Ala Arg Pro Arg Glu 
225                 230                 235                 240 


Glu Val Val Gln Lys Glu Gln Glu 
                245             


<210>  91
<211>  210
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P82979
<309>  2016-09-07
<313>  (1)..(210)

<400>  91

Met Ala Thr Glu Thr Val Glu Leu His Lys Leu Lys Leu Ala Glu Leu 
1               5                   10                  15      


Lys Gln Glu Cys Leu Ala Arg Gly Leu Glu Thr Lys Gly Ile Lys Gln 
            20                  25                  30          


Asp Leu Ile His Arg Leu Gln Ala Tyr Leu Glu Glu His Ala Glu Glu 
        35                  40                  45              


Glu Ala Asn Glu Glu Asp Val Leu Gly Asp Glu Thr Glu Glu Glu Glu 
    50                  55                  60                  


Thr Lys Pro Ile Glu Leu Pro Val Lys Glu Glu Glu Pro Pro Glu Lys 
65                  70                  75                  80  


Thr Val Asp Val Ala Ala Glu Lys Lys Val Val Lys Ile Thr Ser Glu 
                85                  90                  95      


Ile Pro Gln Thr Glu Arg Met Gln Lys Arg Ala Glu Arg Phe Asn Val 
            100                 105                 110         


Pro Val Ser Leu Glu Ser Lys Lys Ala Ala Arg Ala Ala Arg Phe Gly 
        115                 120                 125             


Ile Ser Ser Val Pro Thr Lys Gly Leu Ser Ser Asp Asn Lys Pro Met 
    130                 135                 140                 


Val Asn Leu Asp Lys Leu Lys Glu Arg Ala Gln Arg Phe Gly Leu Asn 
145                 150                 155                 160 


Val Ser Ser Ile Ser Arg Lys Ser Glu Asp Asp Glu Lys Leu Lys Lys 
                165                 170                 175     


Arg Lys Glu Arg Phe Gly Ile Val Thr Ser Ser Ala Gly Thr Gly Thr 
            180                 185                 190         


Thr Glu Asp Thr Glu Ala Lys Lys Arg Lys Arg Ala Glu Arg Phe Gly 
        195                 200                 205             


Ile Ala 
    210 


<210>  92
<211>  501
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q12874
<309>  2016-09-07
<313>  (1)..(501)

<400>  92

Met Glu Thr Ile Leu Glu Gln Gln Arg Arg Tyr His Glu Glu Lys Glu 
1               5                   10                  15      


Arg Leu Met Asp Val Met Ala Lys Glu Met Leu Thr Lys Lys Ser Thr 
            20                  25                  30          


Leu Arg Asp Gln Ile Asn Ser Asp His Arg Thr Arg Ala Met Gln Asp 
        35                  40                  45              


Arg Tyr Met Glu Val Ser Gly Asn Leu Arg Asp Leu Tyr Asp Asp Lys 
    50                  55                  60                  


Asp Gly Leu Arg Lys Glu Glu Leu Asn Ala Ile Ser Gly Pro Asn Glu 
65                  70                  75                  80  


Phe Ala Glu Phe Tyr Asn Arg Leu Lys Gln Ile Lys Glu Phe His Arg 
                85                  90                  95      


Lys His Pro Asn Glu Ile Cys Val Pro Met Ser Val Glu Phe Glu Glu 
            100                 105                 110         


Leu Leu Lys Ala Arg Glu Asn Pro Ser Glu Glu Ala Gln Asn Leu Val 
        115                 120                 125             


Glu Phe Thr Asp Glu Glu Gly Tyr Gly Arg Tyr Leu Asp Leu His Asp 
    130                 135                 140                 


Cys Tyr Leu Lys Tyr Ile Asn Leu Lys Ala Ser Glu Lys Leu Asp Tyr 
145                 150                 155                 160 


Ile Thr Tyr Leu Ser Ile Phe Asp Gln Leu Phe Asp Ile Pro Lys Glu 
                165                 170                 175     


Arg Lys Asn Ala Glu Tyr Lys Arg Tyr Leu Glu Met Leu Leu Glu Tyr 
            180                 185                 190         


Leu Gln Asp Tyr Thr Asp Arg Val Lys Pro Leu Gln Asp Gln Asn Glu 
        195                 200                 205             


Leu Phe Gly Lys Ile Gln Ala Glu Phe Glu Lys Lys Trp Glu Asn Gly 
    210                 215                 220                 


Thr Phe Pro Gly Trp Pro Lys Glu Thr Ser Ser Ala Leu Thr His Ala 
225                 230                 235                 240 


Gly Ala His Leu Asp Leu Ser Ala Phe Ser Ser Trp Glu Glu Leu Ala 
                245                 250                 255     


Ser Leu Gly Leu Asp Arg Leu Lys Ser Ala Leu Leu Ala Leu Gly Leu 
            260                 265                 270         


Lys Cys Gly Gly Thr Leu Glu Glu Arg Ala Gln Arg Leu Phe Ser Thr 
        275                 280                 285             


Lys Gly Lys Ser Leu Glu Ser Leu Asp Thr Ser Leu Phe Ala Lys Asn 
    290                 295                 300                 


Pro Lys Ser Lys Gly Thr Lys Arg Asp Thr Glu Arg Asn Lys Asp Ile 
305                 310                 315                 320 


Ala Phe Leu Glu Ala Gln Ile Tyr Glu Tyr Val Glu Ile Leu Gly Glu 
                325                 330                 335     


Gln Arg His Leu Thr His Glu Asn Val Gln Arg Lys Gln Ala Arg Thr 
            340                 345                 350         


Gly Glu Glu Arg Glu Glu Glu Glu Glu Glu Gln Ile Ser Glu Ser Glu 
        355                 360                 365             


Ser Glu Asp Glu Glu Asn Glu Ile Ile Tyr Asn Pro Lys Asn Leu Pro 
    370                 375                 380                 


Leu Gly Trp Asp Gly Lys Pro Ile Pro Tyr Trp Leu Tyr Lys Leu His 
385                 390                 395                 400 


Gly Leu Asn Ile Asn Tyr Asn Cys Glu Ile Cys Gly Asn Tyr Thr Tyr 
                405                 410                 415     


Arg Gly Pro Lys Ala Phe Gln Arg His Phe Ala Glu Trp Arg His Ala 
            420                 425                 430         


His Gly Met Arg Cys Leu Gly Ile Pro Asn Thr Ala His Phe Ala Asn 
        435                 440                 445             


Val Thr Gln Ile Glu Asp Ala Val Ser Leu Trp Ala Lys Leu Lys Leu 
    450                 455                 460                 


Gln Lys Ala Ser Glu Arg Trp Gln Pro Asp Thr Glu Glu Glu Tyr Glu 
465                 470                 475                 480 


Asp Ser Ser Gly Asn Val Val Asn Lys Lys Thr Tyr Glu Asp Leu Lys 
                485                 490                 495     


Arg Gln Gly Leu Leu 
            500     


<210>  93
<211>  645
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q8IWZ8
<309>  2016-09-07
<313>  (1)..(645)

<400>  93

Met Ser Leu Lys Met Asp Asn Arg Asp Val Ala Gly Lys Ala Asn Arg 
1               5                   10                  15      


Trp Phe Gly Val Ala Pro Pro Lys Ser Gly Lys Met Asn Met Asn Ile 
            20                  25                  30          


Leu His Gln Glu Glu Leu Ile Ala Gln Lys Lys Arg Glu Ile Glu Ala 
        35                  40                  45              


Lys Met Glu Gln Lys Ala Lys Gln Asn Gln Val Ala Ser Pro Gln Pro 
    50                  55                  60                  


Pro His Pro Gly Glu Ile Thr Asn Ala His Asn Ser Ser Cys Ile Ser 
65                  70                  75                  80  


Asn Lys Phe Ala Asn Asp Gly Ser Phe Leu Gln Gln Phe Leu Lys Leu 
                85                  90                  95      


Gln Lys Ala Gln Thr Ser Thr Asp Ala Pro Thr Ser Ala Pro Ser Ala 
            100                 105                 110         


Pro Pro Ser Thr Pro Thr Pro Ser Ala Gly Lys Arg Ser Leu Leu Ile 
        115                 120                 125             


Ser Arg Arg Thr Gly Leu Gly Leu Ala Ser Leu Pro Gly Pro Val Lys 
    130                 135                 140                 


Ser Tyr Ser His Ala Lys Gln Leu Pro Val Ala His Arg Pro Ser Val 
145                 150                 155                 160 


Phe Gln Ser Pro Asp Glu Asp Glu Glu Glu Asp Tyr Glu Gln Trp Leu 
                165                 170                 175     


Glu Ile Lys Val Ser Pro Pro Glu Gly Ala Glu Thr Arg Lys Val Ile 
            180                 185                 190         


Glu Lys Leu Ala Arg Phe Val Ala Glu Gly Gly Pro Glu Leu Glu Lys 
        195                 200                 205             


Val Ala Met Glu Asp Tyr Lys Asp Asn Pro Ala Phe Ala Phe Leu His 
    210                 215                 220                 


Asp Lys Asn Ser Arg Glu Phe Leu Tyr Tyr Arg Lys Lys Val Ala Glu 
225                 230                 235                 240 


Ile Arg Lys Glu Ala Gln Lys Ser Gln Ala Ala Ser Gln Lys Val Ser 
                245                 250                 255     


Pro Pro Glu Asp Glu Glu Val Lys Asn Leu Ala Glu Lys Leu Ala Arg 
            260                 265                 270         


Phe Ile Ala Asp Gly Gly Pro Glu Val Glu Thr Ile Ala Leu Gln Asn 
        275                 280                 285             


Asn Arg Glu Asn Gln Ala Phe Ser Phe Leu Tyr Glu Pro Asn Ser Gln 
    290                 295                 300                 


Gly Tyr Lys Tyr Tyr Arg Gln Lys Leu Glu Glu Phe Arg Lys Ala Lys 
305                 310                 315                 320 


Ala Ser Ser Thr Gly Ser Phe Thr Ala Pro Asp Pro Gly Leu Lys Arg 
                325                 330                 335     


Lys Ser Pro Pro Glu Ala Leu Ser Gly Ser Leu Pro Pro Ala Thr Thr 
            340                 345                 350         


Cys Pro Ala Ser Ser Thr Pro Ala Pro Thr Ile Ile Pro Ala Pro Ala 
        355                 360                 365             


Ala Pro Gly Lys Pro Ala Ser Ala Ala Thr Val Lys Arg Lys Arg Lys 
    370                 375                 380                 


Ser Arg Trp Gly Pro Glu Glu Asp Lys Val Glu Leu Pro Pro Ala Glu 
385                 390                 395                 400 


Leu Val Gln Arg Asp Val Asp Ala Ser Pro Ser Pro Leu Ser Val Gln 
                405                 410                 415     


Asp Leu Lys Gly Leu Gly Tyr Glu Lys Gly Lys Pro Val Gly Leu Val 
            420                 425                 430         


Gly Val Thr Glu Leu Ser Asp Ala Gln Lys Lys Gln Leu Lys Glu Gln 
        435                 440                 445             


Gln Glu Met Gln Gln Met Tyr Asp Met Ile Met Gln His Lys Arg Ala 
    450                 455                 460                 


Met Gln Asp Met Gln Leu Leu Trp Glu Lys Ala Val Gln Gln His Gln 
465                 470                 475                 480 


His Gly Tyr Asp Ser Asp Glu Glu Val Asp Ser Glu Leu Gly Thr Trp 
                485                 490                 495     


Glu His Gln Leu Arg Arg Met Glu Met Asp Lys Thr Arg Glu Trp Ala 
            500                 505                 510         


Glu Gln Leu Thr Lys Met Gly Arg Gly Lys His Phe Ile Gly Asp Phe 
        515                 520                 525             


Leu Pro Pro Asp Glu Leu Glu Lys Phe Met Glu Thr Phe Lys Ala Leu 
    530                 535                 540                 


Lys Glu Gly Arg Glu Pro Asp Tyr Ser Glu Tyr Lys Glu Phe Lys Leu 
545                 550                 555                 560 


Thr Val Glu Asn Ile Gly Tyr Gln Met Leu Met Lys Met Gly Trp Lys 
                565                 570                 575     


Glu Gly Glu Gly Leu Gly Ser Glu Gly Gln Gly Ile Lys Asn Pro Val 
            580                 585                 590         


Asn Lys Gly Thr Thr Thr Val Asp Gly Ala Gly Phe Gly Ile Asp Arg 
        595                 600                 605             


Pro Ala Glu Leu Ser Lys Glu Asp Asp Glu Tyr Glu Ala Phe Arg Lys 
    610                 615                 620                 


Arg Met Met Leu Ala Tyr Arg Phe Arg Pro Asn Pro Leu Asn Asn Pro 
625                 630                 635                 640 


Arg Arg Pro Tyr Tyr 
                645 


<210>  94
<211>  218
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9UBQ5
<309>  2016-09-07
<313>  (1)..(218)

<400>  94

Met Ala Met Phe Glu Gln Met Arg Ala Asn Val Gly Lys Leu Leu Lys 
1               5                   10                  15      


Gly Ile Asp Arg Tyr Asn Pro Glu Asn Leu Ala Thr Leu Glu Arg Tyr 
            20                  25                  30          


Val Glu Thr Gln Ala Lys Glu Asn Ala Tyr Asp Leu Glu Ala Asn Leu 
        35                  40                  45              


Ala Val Leu Lys Leu Tyr Gln Phe Asn Pro Ala Phe Phe Gln Thr Thr 
    50                  55                  60                  


Val Thr Ala Gln Ile Leu Leu Lys Ala Leu Thr Asn Leu Pro His Thr 
65                  70                  75                  80  


Asp Phe Thr Leu Cys Lys Cys Met Ile Asp Gln Ala His Gln Glu Glu 
                85                  90                  95      


Arg Pro Ile Arg Gln Ile Leu Tyr Leu Gly Asp Leu Leu Glu Thr Cys 
            100                 105                 110         


His Phe Gln Ala Phe Trp Gln Ala Leu Asp Glu Asn Met Asp Leu Leu 
        115                 120                 125             


Glu Gly Ile Thr Gly Phe Glu Asp Ser Val Arg Lys Phe Ile Cys His 
    130                 135                 140                 


Val Val Gly Ile Thr Tyr Gln His Ile Asp Arg Trp Leu Leu Ala Glu 
145                 150                 155                 160 


Met Leu Gly Asp Leu Ser Asp Ser Gln Leu Lys Val Trp Met Ser Lys 
                165                 170                 175     


Tyr Gly Trp Ser Ala Asp Glu Ser Gly Gln Ile Phe Ile Cys Ser Gln 
            180                 185                 190         


Glu Glu Ser Ile Lys Pro Lys Asn Ile Val Glu Lys Ile Asp Phe Asp 
        195                 200                 205             


Ser Val Ser Ser Ile Met Ala Ser Ser Gln 
    210                 215             


<210>  95
<211>  785
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P08047
<309>  1993-04-24
<313>  (1)..(785)

<400>  95

Met Ser Asp Gln Asp His Ser Met Asp Glu Met Thr Ala Val Val Lys 
1               5                   10                  15      


Ile Glu Lys Gly Val Gly Gly Asn Asn Gly Gly Asn Gly Asn Gly Gly 
            20                  25                  30          


Gly Ala Phe Ser Gln Ala Arg Ser Ser Ser Thr Gly Ser Ser Ser Ser 
        35                  40                  45              


Thr Gly Gly Gly Gly Gln Glu Ser Gln Pro Ser Pro Leu Ala Leu Leu 
    50                  55                  60                  


Ala Ala Thr Cys Ser Arg Ile Glu Ser Pro Asn Glu Asn Ser Asn Asn 
65                  70                  75                  80  


Ser Gln Gly Pro Ser Gln Ser Gly Gly Thr Gly Glu Leu Asp Leu Thr 
                85                  90                  95      


Ala Thr Gln Leu Ser Gln Gly Ala Asn Gly Trp Gln Ile Ile Ser Ser 
            100                 105                 110         


Ser Ser Gly Ala Thr Pro Thr Ser Lys Glu Gln Ser Gly Ser Ser Thr 
        115                 120                 125             


Asn Gly Ser Asn Gly Ser Glu Ser Ser Lys Asn Arg Thr Val Ser Gly 
    130                 135                 140                 


Gly Gln Tyr Val Val Ala Ala Ala Pro Asn Leu Gln Asn Gln Gln Val 
145                 150                 155                 160 


Leu Thr Gly Leu Pro Gly Val Met Pro Asn Ile Gln Tyr Gln Val Ile 
                165                 170                 175     


Pro Gln Phe Gln Thr Val Asp Gly Gln Gln Leu Gln Phe Ala Ala Thr 
            180                 185                 190         


Gly Ala Gln Val Gln Gln Asp Gly Ser Gly Gln Ile Gln Ile Ile Pro 
        195                 200                 205             


Gly Ala Asn Gln Gln Ile Ile Thr Asn Arg Gly Ser Gly Gly Asn Ile 
    210                 215                 220                 


Ile Ala Ala Met Pro Asn Leu Leu Gln Gln Ala Val Pro Leu Gln Gly 
225                 230                 235                 240 


Leu Ala Asn Asn Val Leu Ser Gly Gln Thr Gln Tyr Val Thr Asn Val 
                245                 250                 255     


Pro Val Ala Leu Asn Gly Asn Ile Thr Leu Leu Pro Val Asn Ser Val 
            260                 265                 270         


Ser Ala Ala Thr Leu Thr Pro Ser Ser Gln Ala Val Thr Ile Ser Ser 
        275                 280                 285             


Ser Gly Ser Gln Glu Ser Gly Ser Gln Pro Val Thr Ser Gly Thr Thr 
    290                 295                 300                 


Ile Ser Ser Ala Ser Leu Val Ser Ser Gln Ala Ser Ser Ser Ser Phe 
305                 310                 315                 320 


Phe Thr Asn Ala Asn Ser Tyr Ser Thr Thr Thr Thr Thr Ser Asn Met 
                325                 330                 335     


Gly Ile Met Asn Phe Thr Thr Ser Gly Ser Ser Gly Thr Asn Ser Gln 
            340                 345                 350         


Gly Gln Thr Pro Gln Arg Val Ser Gly Leu Gln Gly Ser Asp Ala Leu 
        355                 360                 365             


Asn Ile Gln Gln Asn Gln Thr Ser Gly Gly Ser Leu Gln Ala Gly Gln 
    370                 375                 380                 


Gln Lys Glu Gly Glu Gln Asn Gln Gln Thr Gln Gln Gln Gln Ile Leu 
385                 390                 395                 400 


Ile Gln Pro Gln Leu Val Gln Gly Gly Gln Ala Leu Gln Ala Leu Gln 
                405                 410                 415     


Ala Ala Pro Leu Ser Gly Gln Thr Phe Thr Thr Gln Ala Ile Ser Gln 
            420                 425                 430         


Glu Thr Leu Gln Asn Leu Gln Leu Gln Ala Val Pro Asn Ser Gly Pro 
        435                 440                 445             


Ile Ile Ile Arg Thr Pro Thr Val Gly Pro Asn Gly Gln Val Ser Trp 
    450                 455                 460                 


Gln Thr Leu Gln Leu Gln Asn Leu Gln Val Gln Asn Pro Gln Ala Gln 
465                 470                 475                 480 


Thr Ile Thr Leu Ala Pro Met Gln Gly Val Ser Leu Gly Gln Thr Ser 
                485                 490                 495     


Ser Ser Asn Thr Thr Leu Thr Pro Ile Ala Ser Ala Ala Ser Ile Pro 
            500                 505                 510         


Ala Gly Thr Val Thr Val Asn Ala Ala Gln Leu Ser Ser Met Pro Gly 
        515                 520                 525             


Leu Gln Thr Ile Asn Leu Ser Ala Leu Gly Thr Ser Gly Ile Gln Val 
    530                 535                 540                 


His Pro Ile Gln Gly Leu Pro Leu Ala Ile Ala Asn Ala Pro Gly Asp 
545                 550                 555                 560 


His Gly Ala Gln Leu Gly Leu His Gly Ala Gly Gly Asp Gly Ile His 
                565                 570                 575     


Asp Asp Thr Ala Gly Gly Glu Glu Gly Glu Asn Ser Pro Asp Ala Gln 
            580                 585                 590         


Pro Gln Ala Gly Arg Arg Thr Arg Arg Glu Ala Cys Thr Cys Pro Tyr 
        595                 600                 605             


Cys Lys Asp Ser Glu Gly Arg Gly Ser Gly Asp Pro Gly Lys Lys Lys 
    610                 615                 620                 


Gln His Ile Cys His Ile Gln Gly Cys Gly Lys Val Tyr Gly Lys Thr 
625                 630                 635                 640 


Ser His Leu Arg Ala His Leu Arg Trp His Thr Gly Glu Arg Pro Phe 
                645                 650                 655     


Met Cys Thr Trp Ser Tyr Cys Gly Lys Arg Phe Thr Arg Ser Asp Glu 
            660                 665                 670         


Leu Gln Arg His Lys Arg Thr His Thr Gly Glu Lys Lys Phe Ala Cys 
        675                 680                 685             


Pro Glu Cys Pro Lys Arg Phe Met Arg Ser Asp His Leu Ser Lys His 
    690                 695                 700                 


Ile Lys Thr His Gln Asn Lys Lys Gly Gly Pro Gly Val Ala Leu Ser 
705                 710                 715                 720 


Val Gly Thr Leu Pro Leu Asp Ser Gly Ala Gly Ser Glu Gly Ser Gly 
                725                 730                 735     


Thr Ala Thr Pro Ser Ala Leu Ile Thr Thr Asn Met Val Ala Met Glu 
            740                 745                 750         


Ala Ile Cys Pro Glu Gly Ile Ala Arg Leu Ala Asn Ser Gly Ile Asn 
        755                 760                 765             


Val Met Gln Val Ala Asp Leu Gln Ser Ile Asn Ile Ser Gly Asn Gly 
    770                 775                 780                 


Phe 
785 


<210>  96
<211>  798
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q14241
<309>  2016-09-07
<313>  (1)..(798)

<400>  96

Met His Gly Gly Arg Ser Cys Gly Pro Arg Thr Arg Arg Glu Pro Ser 
1               5                   10                  15      


Ser Gly Glu Glu Ala Ala Pro Val Thr Ala Met Ala Ala Glu Ser Ala 
            20                  25                  30          


Leu Gln Val Val Glu Lys Leu Gln Ala Arg Leu Ala Ala Asn Pro Asp 
        35                  40                  45              


Pro Lys Lys Leu Leu Lys Tyr Leu Lys Lys Leu Ser Thr Leu Pro Ile 
    50                  55                  60                  


Thr Val Asp Ile Leu Ala Glu Thr Gly Val Gly Lys Thr Val Asn Ser 
65                  70                  75                  80  


Leu Arg Lys His Glu His Val Gly Ser Phe Ala Arg Asp Leu Val Ala 
                85                  90                  95      


Gln Trp Lys Lys Leu Val Pro Val Glu Arg Asn Ala Glu Pro Asp Glu 
            100                 105                 110         


Gln Asp Phe Glu Lys Ser Asn Ser Arg Lys Arg Pro Arg Asp Ala Leu 
        115                 120                 125             


Gln Lys Glu Glu Glu Met Glu Gly Asp Tyr Gln Glu Thr Trp Lys Ala 
    130                 135                 140                 


Thr Gly Ser Arg Ser Tyr Ser Pro Asp His Arg Gln Lys Lys His Arg 
145                 150                 155                 160 


Lys Leu Ser Glu Leu Glu Arg Pro His Lys Val Ser His Gly His Glu 
                165                 170                 175     


Arg Arg Asp Glu Arg Lys Arg Cys His Arg Met Ser Pro Thr Tyr Ser 
            180                 185                 190         


Ser Asp Pro Glu Ser Ser Asp Tyr Gly His Val Gln Ser Pro Pro Ser 
        195                 200                 205             


Cys Thr Ser Pro His Gln Met Tyr Val Asp His Tyr Arg Ser Leu Glu 
    210                 215                 220                 


Glu Asp Gln Glu Pro Ile Val Ser His Gln Lys Pro Gly Lys Gly His 
225                 230                 235                 240 


Ser Asn Ala Phe Gln Asp Arg Leu Gly Ala Ser Gln Glu Arg His Leu 
                245                 250                 255     


Gly Glu Pro His Gly Lys Gly Val Val Ser Gln Asn Lys Glu His Lys 
            260                 265                 270         


Ser Ser His Lys Asp Lys Arg Pro Val Asp Ala Lys Ser Asp Glu Lys 
        275                 280                 285             


Ala Ser Val Val Ser Arg Glu Lys Ser His Lys Ala Leu Ser Lys Glu 
    290                 295                 300                 


Glu Asn Arg Arg Pro Pro Ser Gly Asp Asn Ala Arg Glu Lys Pro Pro 
305                 310                 315                 320 


Ser Ser Gly Val Lys Lys Glu Lys Asp Arg Glu Gly Ser Ser Leu Lys 
                325                 330                 335     


Lys Lys Cys Leu Pro Pro Ser Glu Ala Ala Ser Asp Asn His Leu Lys 
            340                 345                 350         


Lys Pro Lys His Arg Asp Pro Glu Lys Ala Lys Leu Asp Lys Ser Lys 
        355                 360                 365             


Gln Gly Leu Asp Ser Phe Asp Thr Gly Lys Gly Ala Gly Asp Leu Leu 
    370                 375                 380                 


Pro Lys Val Lys Glu Lys Gly Ser Asn Asn Leu Lys Thr Pro Glu Gly 
385                 390                 395                 400 


Lys Val Lys Thr Asn Leu Asp Arg Lys Ser Leu Gly Ser Leu Pro Lys 
                405                 410                 415     


Val Glu Glu Thr Asp Met Glu Asp Glu Phe Glu Gln Pro Thr Met Ser 
            420                 425                 430         


Phe Glu Ser Tyr Leu Ser Tyr Asp Gln Pro Arg Lys Lys Lys Lys Lys 
        435                 440                 445             


Ile Val Lys Thr Ser Ala Thr Ala Leu Gly Asp Lys Gly Leu Lys Lys 
    450                 455                 460                 


Asn Asp Ser Lys Ser Thr Gly Lys Asn Leu Asp Ser Val Gln Lys Leu 
465                 470                 475                 480 


Pro Lys Val Asn Lys Thr Lys Ser Glu Lys Pro Ala Gly Ala Asp Leu 
                485                 490                 495     


Ala Lys Leu Arg Lys Val Pro Asp Val Leu Pro Val Leu Pro Asp Leu 
            500                 505                 510         


Pro Leu Pro Ala Ile Gln Ala Asn Tyr Arg Pro Leu Pro Ser Leu Glu 
        515                 520                 525             


Leu Ile Ser Ser Phe Gln Pro Lys Arg Lys Ala Phe Ser Ser Pro Gln 
    530                 535                 540                 


Glu Glu Glu Glu Ala Gly Phe Thr Gly Arg Arg Met Asn Ser Lys Met 
545                 550                 555                 560 


Gln Val Tyr Ser Gly Ser Lys Cys Ala Tyr Leu Pro Lys Met Met Thr 
                565                 570                 575     


Leu His Gln Gln Cys Ile Arg Val Leu Lys Asn Asn Ile Asp Ser Ile 
            580                 585                 590         


Phe Glu Val Gly Gly Val Pro Tyr Ser Val Leu Glu Pro Val Leu Glu 
        595                 600                 605             


Arg Cys Thr Pro Asp Gln Leu Tyr Arg Ile Glu Glu Tyr Asn His Val 
    610                 615                 620                 


Leu Ile Glu Glu Thr Asp Gln Leu Trp Lys Val His Cys His Arg Asp 
625                 630                 635                 640 


Phe Lys Glu Glu Arg Pro Glu Glu Tyr Glu Ser Trp Arg Glu Met Tyr 
                645                 650                 655     


Leu Arg Leu Gln Asp Ala Arg Glu Gln Arg Leu Arg Val Leu Thr Lys 
            660                 665                 670         


Asn Ile Gln Phe Ala His Ala Asn Lys Pro Lys Gly Arg Gln Ala Lys 
        675                 680                 685             


Met Ala Phe Val Asn Ser Val Ala Lys Pro Pro Arg Asp Val Arg Arg 
    690                 695                 700                 


Arg Gln Glu Lys Phe Gly Thr Gly Gly Ala Ala Val Pro Glu Lys Ile 
705                 710                 715                 720 


Lys Ile Lys Pro Ala Pro Tyr Pro Met Gly Ser Ser His Ala Ser Ala 
                725                 730                 735     


Ser Ser Ile Ser Phe Asn Pro Ser Pro Glu Glu Pro Ala Tyr Asp Gly 
            740                 745                 750         


Pro Ser Thr Ser Ser Ala His Leu Ala Pro Val Val Ser Ser Thr Val 
        755                 760                 765             


Ser Tyr Asp Pro Arg Lys Pro Thr Val Lys Lys Ile Ala Pro Met Met 
    770                 775                 780                 


Ala Lys Thr Ile Lys Ala Phe Lys Asn Arg Phe Ser Arg Arg 
785                 790                 795             


<210>  97
<211>  1498
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P42695
<309>  2016-09-07
<313>  (1)..(1498)

<400>  97

Met Val Ala Leu Arg Gly Leu Gly Ser Gly Leu Gln Pro Trp Cys Pro 
1               5                   10                  15      


Leu Asp Leu Arg Leu Glu Trp Val Asp Thr Val Trp Glu Leu Asp Phe 
            20                  25                  30          


Thr Glu Thr Glu Pro Leu Asp Pro Ser Ile Glu Ala Glu Ile Ile Glu 
        35                  40                  45              


Thr Gly Leu Ala Ala Phe Thr Lys Leu Tyr Glu Ser Leu Leu Pro Phe 
    50                  55                  60                  


Ala Thr Gly Glu His Gly Ser Met Glu Ser Ile Trp Thr Phe Phe Ile 
65                  70                  75                  80  


Glu Asn Asn Val Ser His Ser Thr Leu Val Ala Leu Phe Tyr His Phe 
                85                  90                  95      


Val Gln Ile Val His Lys Lys Asn Val Ser Val Gln Tyr Arg Glu Tyr 
            100                 105                 110         


Gly Leu His Ala Ala Gly Leu Tyr Phe Leu Leu Leu Glu Val Pro Gly 
        115                 120                 125             


Ser Val Ala Asn Gln Val Phe His Pro Val Met Phe Asp Lys Cys Ile 
    130                 135                 140                 


Gln Thr Leu Lys Lys Ser Trp Pro Gln Glu Ser Asn Leu Asn Arg Lys 
145                 150                 155                 160 


Arg Lys Lys Glu Gln Pro Lys Ser Ser Gln Ala Asn Pro Gly Arg His 
                165                 170                 175     


Arg Lys Arg Gly Lys Pro Pro Arg Arg Glu Asp Ile Glu Met Asp Glu 
            180                 185                 190         


Ile Ile Glu Glu Gln Glu Asp Glu Asn Ile Cys Phe Ser Ala Arg Asp 
        195                 200                 205             


Leu Ser Gln Ile Arg Asn Ala Ile Phe His Leu Leu Lys Asn Phe Leu 
    210                 215                 220                 


Arg Leu Leu Pro Lys Phe Ser Leu Lys Glu Lys Pro Gln Cys Val Gln 
225                 230                 235                 240 


Asn Cys Ile Glu Val Phe Val Ser Leu Thr Asn Phe Glu Pro Val Leu 
                245                 250                 255     


His Glu Cys His Val Thr Gln Ala Arg Ala Leu Asn Gln Ala Lys Tyr 
            260                 265                 270         


Ile Pro Glu Leu Ala Tyr Tyr Gly Leu Tyr Leu Leu Cys Ser Pro Ile 
        275                 280                 285             


His Gly Glu Gly Asp Lys Val Ile Ser Cys Val Phe His Gln Met Leu 
    290                 295                 300                 


Ser Val Ile Leu Met Leu Glu Val Gly Glu Gly Ser His Arg Ala Pro 
305                 310                 315                 320 


Leu Ala Val Thr Ser Gln Val Ile Asn Cys Arg Asn Gln Ala Val Gln 
                325                 330                 335     


Phe Ile Ser Ala Leu Val Asp Glu Leu Lys Glu Ser Ile Phe Pro Val 
            340                 345                 350         


Val Arg Ile Leu Leu Gln His Ile Cys Ala Lys Val Val Asp Lys Ser 
        355                 360                 365             


Glu Tyr Arg Thr Phe Ala Ala Gln Ser Leu Val Gln Leu Leu Ser Lys 
    370                 375                 380                 


Leu Pro Cys Gly Glu Tyr Ala Met Phe Ile Ala Trp Leu Tyr Lys Tyr 
385                 390                 395                 400 


Ser Arg Ser Ser Lys Ile Pro His Arg Val Phe Thr Leu Asp Val Val 
                405                 410                 415     


Leu Ala Leu Leu Glu Leu Pro Glu Arg Glu Val Asp Asn Thr Leu Ser 
            420                 425                 430         


Leu Glu His Gln Lys Phe Leu Lys His Lys Phe Leu Val Gln Glu Ile 
        435                 440                 445             


Met Phe Asp Arg Cys Leu Asp Lys Ala Pro Thr Val Arg Ser Lys Ala 
    450                 455                 460                 


Leu Ser Ser Phe Ala His Cys Leu Glu Leu Thr Val Thr Ser Ala Ser 
465                 470                 475                 480 


Glu Ser Ile Leu Glu Leu Leu Ile Asn Ser Pro Thr Phe Ser Val Ile 
                485                 490                 495     


Glu Ser His Pro Gly Thr Leu Leu Arg Asn Ser Ser Ala Phe Ser Tyr 
            500                 505                 510         


Gln Arg Gln Thr Ser Asn Arg Ser Glu Pro Ser Gly Glu Ile Asn Ile 
        515                 520                 525             


Asp Ser Ser Gly Glu Thr Val Gly Ser Gly Glu Arg Cys Val Met Ala 
    530                 535                 540                 


Met Leu Arg Arg Arg Ile Arg Asp Glu Lys Thr Asn Val Arg Lys Ser 
545                 550                 555                 560 


Ala Leu Gln Val Leu Val Ser Ile Leu Lys His Cys Asp Val Ser Gly 
                565                 570                 575     


Met Lys Glu Asp Leu Trp Ile Leu Gln Asp Gln Cys Arg Asp Pro Ala 
            580                 585                 590         


Val Ser Val Arg Lys Gln Ala Leu Gln Ser Leu Thr Glu Leu Leu Met 
        595                 600                 605             


Ala Gln Pro Arg Cys Val Gln Ile Gln Lys Ala Trp Leu Arg Gly Val 
    610                 615                 620                 


Val Pro Val Val Met Asp Cys Glu Ser Thr Val Gln Glu Lys Ala Leu 
625                 630                 635                 640 


Glu Phe Leu Asp Gln Leu Leu Leu Gln Asn Ile Arg His His Ser His 
                645                 650                 655     


Phe His Ser Gly Asp Asp Ser Gln Val Leu Ala Trp Ala Leu Leu Thr 
            660                 665                 670         


Leu Leu Thr Thr Glu Ser Gln Glu Leu Ser Arg Tyr Leu Asn Lys Ala 
        675                 680                 685             


Phe His Ile Trp Ser Lys Lys Glu Lys Phe Ser Pro Thr Phe Ile Asn 
    690                 695                 700                 


Asn Val Ile Ser His Thr Gly Thr Glu His Ser Ala Pro Ala Trp Met 
705                 710                 715                 720 


Leu Leu Ser Lys Ile Ala Gly Ser Ser Pro Arg Leu Asp Tyr Ser Arg 
                725                 730                 735     


Ile Ile Gln Ser Trp Glu Lys Ile Ser Ser Gln Gln Asn Pro Asn Ser 
            740                 745                 750         


Asn Thr Leu Gly His Ile Leu Cys Val Ile Gly His Ile Ala Lys His 
        755                 760                 765             


Leu Pro Lys Ser Thr Arg Asp Lys Val Thr Asp Ala Val Lys Cys Lys 
    770                 775                 780                 


Leu Asn Gly Phe Gln Trp Ser Leu Glu Val Ile Ser Ser Ala Val Asp 
785                 790                 795                 800 


Ala Leu Gln Arg Leu Cys Arg Ala Ser Ala Glu Thr Pro Ala Glu Glu 
                805                 810                 815     


Gln Glu Leu Leu Thr Gln Val Cys Gly Asp Val Leu Ser Thr Cys Glu 
            820                 825                 830         


His Arg Leu Ser Asn Ile Val Leu Lys Glu Asn Gly Thr Gly Asn Met 
        835                 840                 845             


Asp Glu Asp Leu Leu Val Lys Tyr Ile Phe Thr Leu Gly Asp Ile Ala 
    850                 855                 860                 


Gln Leu Cys Pro Ala Arg Val Glu Lys Arg Ile Phe Leu Leu Ile Gln 
865                 870                 875                 880 


Ser Val Leu Ala Ser Ser Ala Asp Ala Asp His Ser Pro Ser Ser Gln 
                885                 890                 895     


Gly Ser Ser Glu Ala Pro Ala Ser Gln Pro Pro Pro Gln Val Arg Gly 
            900                 905                 910         


Ser Val Met Pro Ser Val Ile Arg Ala His Ala Ile Ile Thr Leu Gly 
        915                 920                 925             


Lys Leu Cys Leu Gln His Glu Asp Leu Ala Lys Lys Ser Ile Pro Ala 
    930                 935                 940                 


Leu Val Arg Glu Leu Glu Val Cys Glu Asp Val Ala Val Arg Asn Asn 
945                 950                 955                 960 


Val Ile Ile Val Met Cys Asp Leu Cys Ile Arg Tyr Thr Ile Met Val 
                965                 970                 975     


Asp Lys Tyr Ile Pro Asn Ile Ser Met Cys Leu Lys Asp Ser Asp Pro 
            980                 985                 990         


Phe Ile Arg Lys Gln Thr Leu Ile  Leu Leu Thr Asn Leu  Leu Gln Glu 
        995                 1000                 1005             


Glu Phe  Val Lys Trp Lys Gly  Ser Leu Phe Phe Arg  Phe Val Ser 
    1010                 1015                 1020             


Thr Leu  Ile Asp Ser His Pro  Asp Ile Ala Ser Phe  Gly Glu Phe 
    1025                 1030                 1035             


Cys Leu  Ala His Leu Leu Leu  Lys Arg Asn Pro Val  Met Phe Phe 
    1040                 1045                 1050             


Gln His  Phe Ile Glu Cys Ile  Phe His Phe Asn Asn  Tyr Glu Lys 
    1055                 1060                 1065             


His Glu  Lys Tyr Asn Lys Phe  Pro Gln Ser Glu Arg  Glu Lys Arg 
    1070                 1075                 1080             


Leu Phe  Ser Leu Lys Gly Lys  Ser Asn Lys Glu Arg  Arg Met Lys 
    1085                 1090                 1095             


Ile Tyr  Lys Phe Leu Leu Glu  His Phe Thr Asp Glu  Gln Arg Phe 
    1100                 1105                 1110             


Asn Ile  Thr Ser Lys Ile Cys  Leu Ser Ile Leu Ala  Cys Phe Ala 
    1115                 1120                 1125             


Asp Gly  Ile Leu Pro Leu Asp  Leu Asp Ala Ser Glu  Leu Leu Ser 
    1130                 1135                 1140             


Asp Thr  Phe Glu Val Leu Ser  Ser Lys Glu Ile Lys  Leu Leu Ala 
    1145                 1150                 1155             


Met Arg  Ser Lys Pro Asp Lys  Asp Leu Leu Met Glu  Glu Asp Asp 
    1160                 1165                 1170             


Met Ala  Leu Ala Asn Val Val  Met Gln Glu Ala Gln  Lys Lys Leu 
    1175                 1180                 1185             


Ile Ser  Gln Val Gln Lys Arg  Asn Phe Ile Glu Asn  Ile Ile Pro 
    1190                 1195                 1200             


Ile Ile  Ile Ser Leu Lys Thr  Val Leu Glu Lys Asn  Lys Ile Pro 
    1205                 1210                 1215             


Ala Leu  Arg Glu Leu Met His  Tyr Leu Arg Glu Val  Met Gln Asp 
    1220                 1225                 1230             


Tyr Arg  Asp Glu Leu Lys Asp  Phe Phe Ala Val Asp  Lys Gln Leu 
    1235                 1240                 1245             


Ala Ser  Glu Leu Glu Tyr Asp  Met Lys Lys Tyr Gln  Glu Gln Leu 
    1250                 1255                 1260             


Val Gln  Glu Gln Glu Leu Ala  Lys His Ala Asp Val  Ala Gly Thr 
    1265                 1270                 1275             


Ala Gly  Gly Ala Glu Val Ala  Pro Val Ala Gln Val  Ala Leu Cys 
    1280                 1285                 1290             


Leu Glu  Thr Val Pro Val Pro  Ala Gly Gln Glu Asn  Pro Ala Met 
    1295                 1300                 1305             


Ser Pro  Ala Val Ser Gln Pro  Cys Thr Pro Arg Ala  Ser Ala Gly 
    1310                 1315                 1320             


His Val  Ala Val Ser Ser Pro  Thr Pro Glu Thr Gly  Pro Leu Gln 
    1325                 1330                 1335             


Arg Leu  Leu Pro Lys Ala Arg  Pro Met Ser Leu Ser  Thr Ile Ala 
    1340                 1345                 1350             


Ile Leu  Asn Ser Val Lys Lys  Ala Val Glu Ser Lys  Ser Arg His 
    1355                 1360                 1365             


Arg Ser  Arg Ser Leu Gly Val  Leu Pro Phe Thr Leu  Asn Ser Gly 
    1370                 1375                 1380             


Ser Pro  Glu Lys Thr Cys Ser  Gln Val Ser Ser Tyr  Ser Leu Glu 
    1385                 1390                 1395             


Gln Glu  Ser Asn Gly Glu Ile  Glu His Val Thr Lys  Arg Ala Ile 
    1400                 1405                 1410             


Ser Thr  Pro Glu Lys Ser Ile  Ser Asp Val Thr Phe  Gly Ala Gly 
    1415                 1420                 1425             


Val Ser  Tyr Ile Gly Thr Pro  Arg Thr Pro Ser Ser  Ala Lys Glu 
    1430                 1435                 1440             


Lys Ile  Glu Gly Arg Ser Gln  Gly Asn Asp Ile Leu  Cys Leu Ser 
    1445                 1450                 1455             


Leu Pro  Asp Lys Pro Pro Pro  Gln Pro Gln Gln Trp  Asn Val Arg 
    1460                 1465                 1470             


Ser Pro  Ala Arg Asn Lys Asp  Thr Pro Ala Cys Ser  Arg Arg Ser 
    1475                 1480                 1485             


Leu Arg  Lys Thr Pro Leu Lys  Thr Ala Asn 
    1490                 1495             


<210>  98
<211>  5059
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q8NDA2
<309>  2016-09-07
<313>  (1)..(5059)

<400>  98

Met Pro Gly Ala Pro Leu Leu Arg Leu Leu Thr Ala Val Ser Ala Ala 
1               5                   10                  15      


Val Ala Val Ala Val Ala Gly Ala Pro Gly Thr Val Met Pro Pro Thr 
            20                  25                  30          


Thr Gly Asp Ala Thr Leu Ala Phe Val Phe Asp Val Thr Gly Ser Met 
        35                  40                  45              


Trp Asp Glu Leu Met Gln Val Ile Asp Gly Ala Ser Arg Ile Leu Glu 
    50                  55                  60                  


Arg Ser Leu Ser Arg Arg Ser Gln Ala Ile Ala Asn Tyr Ala Leu Val 
65                  70                  75                  80  


Pro Phe His Asp Pro Asp Ile Gly Pro Val Thr Leu Thr Ala Asp Pro 
                85                  90                  95      


Thr Val Phe Gln Arg Glu Leu Arg Glu Leu Tyr Val Gln Gly Gly Gly 
            100                 105                 110         


Asp Cys Pro Glu Met Ser Val Gly Ala Ile Lys Ala Ala Val Glu Val 
        115                 120                 125             


Ala Asn Pro Gly Ser Phe Ile Tyr Val Phe Ser Asp Ala Arg Ala Lys 
    130                 135                 140                 


Asp Tyr His Lys Lys Glu Glu Leu Leu Arg Leu Leu Gln Leu Lys Gln 
145                 150                 155                 160 


Ser Gln Val Val Phe Val Leu Thr Gly Asp Cys Gly Asp Arg Thr His 
                165                 170                 175     


Pro Gly Tyr Leu Ala Tyr Glu Glu Ile Ala Ala Thr Ser Ser Gly Gln 
            180                 185                 190         


Val Phe His Leu Asp Lys Gln Gln Val Thr Glu Val Leu Lys Trp Val 
        195                 200                 205             


Glu Ser Ala Ile Gln Ala Ser Lys Val His Leu Leu Ser Thr Asp His 
    210                 215                 220                 


Glu Glu Glu Gly Glu His Thr Trp Arg Leu Pro Phe Asp Pro Ser Leu 
225                 230                 235                 240 


Lys Glu Val Thr Ile Ser Leu Ser Gly Pro Gly Pro Glu Ile Glu Val 
                245                 250                 255     


Gln Asp Pro Leu Gly Arg Ile Leu Gln Glu Asp Glu Gly Leu Asn Val 
            260                 265                 270         


Leu Leu Asn Ile Pro Asp Ser Ala Lys Val Val Ala Phe Lys Pro Glu 
        275                 280                 285             


His Pro Gly Leu Trp Ser Ile Lys Val Tyr Ser Ser Gly Arg His Ser 
    290                 295                 300                 


Val Arg Ile Thr Gly Val Ser Asn Ile Asp Phe Arg Ala Gly Phe Ser 
305                 310                 315                 320 


Thr Gln Pro Leu Leu Asp Leu Asn His Thr Leu Glu Trp Pro Leu Gln 
                325                 330                 335     


Gly Val Pro Ile Ser Leu Val Ile Asn Ser Thr Gly Leu Lys Ala Pro 
            340                 345                 350         


Gly Arg Leu Asp Ser Val Glu Leu Ala Gln Ser Ser Gly Lys Pro Leu 
        355                 360                 365             


Leu Thr Leu Pro Thr Lys Pro Leu Ser Asn Gly Ser Thr His Gln Leu 
    370                 375                 380                 


Trp Gly Gly Pro Pro Phe His Thr Pro Lys Glu Arg Phe Tyr Leu Lys 
385                 390                 395                 400 


Val Lys Gly Lys Asp His Glu Gly Asn Pro Leu Leu Arg Val Ser Gly 
                405                 410                 415     


Val Ser Tyr Ser Gly Val Ala Pro Gly Ala Pro Leu Val Ser Met Ala 
            420                 425                 430         


Pro Arg Ile His Gly Tyr Leu His Gln Pro Leu Leu Val Ser Cys Ser 
        435                 440                 445             


Val His Ser Ala Leu Pro Phe Arg Leu Gln Leu Arg Arg Gly Glu Ala 
    450                 455                 460                 


Arg Leu Gly Glu Glu Arg His Phe Gln Glu Ser Gly Asn Ser Ser Trp 
465                 470                 475                 480 


Glu Ile Leu Arg Ala Ser Lys Ala Glu Glu Gly Thr Tyr Glu Cys Thr 
                485                 490                 495     


Ala Val Ser Arg Ala Gly Thr Gly Arg Ala Lys Ala Gln Ile Val Val 
            500                 505                 510         


Thr Asp Pro Pro Pro Gln Leu Val Pro Ala Pro Asn Val Thr Val Ser 
        515                 520                 525             


Pro Gly Glu Thr Ala Val Leu Ser Cys Arg Val Leu Gly Glu Ala Pro 
    530                 535                 540                 


Tyr Asn Leu Thr Trp Val Arg Asp Trp Arg Val Leu Pro Ala Ser Thr 
545                 550                 555                 560 


Gly Arg Val Ala Gln Leu Ala Asp Leu Ser Leu Glu Ile Ser Gly Ile 
                565                 570                 575     


Ile Pro Thr Asp Gly Gly Arg Tyr Gln Cys Val Ala Ser Asn Ala Asn 
            580                 585                 590         


Gly Val Thr Arg Ala Ser Val Trp Leu Leu Val Arg Glu Ala Pro Gln 
        595                 600                 605             


Val Ser Ile His Thr Ser Ser Gln His Phe Ser Gln Gly Val Glu Val 
    610                 615                 620                 


Lys Val Ser Cys Ser Ala Ser Gly Tyr Pro Thr Pro His Ile Ser Trp 
625                 630                 635                 640 


Ser Arg Glu Ser Gln Ala Leu Gln Glu Asp Ser Arg Ile His Val Asp 
                645                 650                 655     


Ala Gln Gly Thr Leu Ile Ile Gln Gly Val Ala Pro Glu Asp Ala Gly 
            660                 665                 670         


Asn Tyr Ser Cys Gln Ala Thr Asn Glu Val Gly Thr Asp Gln Glu Thr 
        675                 680                 685             


Val Thr Leu Tyr Tyr Thr Asp Pro Pro Ser Val Ser Ala Val Asn Ala 
    690                 695                 700                 


Val Val Leu Val Ala Val Gly Glu Glu Ala Val Leu Val Cys Glu Ala 
705                 710                 715                 720 


Ser Gly Val Pro Pro Pro Arg Val Ile Trp Tyr Arg Gly Gly Leu Glu 
                725                 730                 735     


Met Ile Leu Ala Pro Glu Gly Ser Ser Ser Gly Lys Leu Arg Ile Pro 
            740                 745                 750         


Ala Ala Gln Glu Arg Asp Ala Gly Thr Tyr Thr Cys Arg Ala Val Asn 
        755                 760                 765             


Glu Leu Gly Asp Ala Ser Ala Glu Ile Gln Leu Ala Val Gly His Ala 
    770                 775                 780                 


Pro Gln Leu Thr Glu Leu Pro Arg Asp Val Thr Val Glu Leu Gly Arg 
785                 790                 795                 800 


Ser Ala Leu Leu Ala Cys Arg Ala Thr Gly Arg Pro Pro Pro Thr Val 
                805                 810                 815     


Thr Trp Arg Arg Gly Asp Gly Gln Pro Leu Gly Leu Arg Leu Gly Ala 
            820                 825                 830         


Gly Arg Gly Ser Arg Ser Arg Gln Pro Asp Ser Gly Val Leu Phe Phe 
        835                 840                 845             


Glu Ser Val Ala Pro Glu Asp Gln Ala Pro Tyr Val Cys Glu Ala Arg 
    850                 855                 860                 


Asn Val Phe Gly Lys Val Gln Ala Glu Ala Arg Leu Ile Val Thr Gly 
865                 870                 875                 880 


His Ala Pro Pro Gln Ile Ala Ser Ser Ala Pro Thr Val Arg Val Leu 
                885                 890                 895     


Glu Gly Gln Pro Val Ser Leu Pro Cys Ile Val Leu Ala Gly Arg Pro 
            900                 905                 910         


Leu Pro Glu Arg His Trp Leu Lys Asp Gly Arg Pro Leu Pro Pro Gly 
        915                 920                 925             


Ser Arg His Ser Ile Arg Ala Asp Gly Ser Leu His Leu Asp Arg Ala 
    930                 935                 940                 


Leu Gln Glu His Ala Gly Arg Tyr Ser Cys Val Ala Thr Asn Thr Ala 
945                 950                 955                 960 


Gly Ser Gln His Arg Asp Val Glu Leu Val Val Gln Val Pro Pro Arg 
                965                 970                 975     


Ile His Pro Thr Ala Thr His His Ile Thr Asn Glu Gly Val Ala Ala 
            980                 985                 990         


Ser Leu Pro Cys Val Ala Ser Gly  Val Pro Ala Pro Thr  Ile Thr Trp 
        995                 1000                 1005             


Thr Lys  Glu Thr Asn Ala Leu  Thr Ser Arg Gly Pro  His Tyr Asn 
    1010                 1015                 1020             


Val Ser  Lys Glu Gly Thr Leu  Leu Ile Ala Gln Pro  Ser Ala Gln 
    1025                 1030                 1035             


Asp Ala  Gly Ala Tyr Val Cys  Thr Ala Thr Asn Thr  Val Gly Phe 
    1040                 1045                 1050             


Ser Ser  Gln Glu Met Arg Leu  Ser Val Asn Thr Lys  Pro Arg Ile 
    1055                 1060                 1065             


His Met  Asn Gly Ser Arg Asn  Ala Asp Val Pro Leu  Gln Val Thr 
    1070                 1075                 1080             


Ala Lys  Ala Gly Glu Glu Val  Thr Leu Asp Cys Glu  Ala Lys Gly 
    1085                 1090                 1095             


Ser Pro  Pro Pro Leu Val Thr  Trp Thr Lys Asp Ser  Arg Pro Val 
    1100                 1105                 1110             


Pro Pro  Ile Thr Asn Arg Tyr  Gly Leu Leu Pro Ser  Gly Ser Leu 
    1115                 1120                 1125             


Arg Leu  Ala Gln Val Gln Val  Gly Asp Ser Gly His  Tyr Glu Cys 
    1130                 1135                 1140             


Thr Ala  Ser Asn Pro Ala Gly  Ser Ala Ser His Arg  Tyr Val Leu 
    1145                 1150                 1155             


Gly Val  Gln Val Pro Pro Gln  Val Gln Pro Gly Pro  Arg Val Leu 
    1160                 1165                 1170             


Lys Val  Leu Val Gly Glu Ala  Leu Asp Leu Asn Cys  Val Ala Glu 
    1175                 1180                 1185             


Gly Asn  Pro Glu Pro Gln Leu  Ser Trp Ser Lys Asp  Gly Val Val 
    1190                 1195                 1200             


Leu Gln  Gly Arg Gly Pro Gln  Gly Ser Val His Phe  Ala Ala Ile 
    1205                 1210                 1215             


Arg Thr  Ser Asp Ala Gly Arg  Tyr Arg Cys Glu Ala  Ser Asn Ser 
    1220                 1225                 1230             


Ala Gly  Val Asp Ala Trp Glu  Val Glu Leu Arg Val  Leu Glu Pro 
    1235                 1240                 1245             


Pro His  Trp Gly Ala Asp Glu  Thr Ser Gly Leu Leu  Glu Arg Val 
    1250                 1255                 1260             


Ala Gly  Glu Asn Ala Ser Leu  Pro Cys Pro Ala Arg  Gly Thr Pro 
    1265                 1270                 1275             


Lys Pro  Gln Val Thr Trp Arg  Lys Gly Pro Ser Ser  Glu Pro Leu 
    1280                 1285                 1290             


His Gly  Gln Pro Gly Val Ala  Val Leu Glu Glu Gly  Ser Leu Phe 
    1295                 1300                 1305             


Leu Ala  Ser Val Ser Pro Ala  Asp Ser Gly Asp Tyr  Glu Cys Gln 
    1310                 1315                 1320             


Ala Thr  Asn Glu Val Gly Ser  Thr Ser Arg Arg Ala  Lys Leu Val 
    1325                 1330                 1335             


Val Tyr  Val Pro Pro Ser Ile  Arg Glu Asp Gly Arg  Lys Ala Asn 
    1340                 1345                 1350             


Val Ser  Gly Met Ala Gly Gln  Ser Leu Thr Leu Glu  Cys Asp Ala 
    1355                 1360                 1365             


Asn Gly  Phe Pro Val Pro Glu  Ile Val Trp Leu Lys  Asp Ala Gln 
    1370                 1375                 1380             


Leu Ile  Pro Lys Val Gly Gly  His Arg Leu Leu Asp  Glu Gly Gln 
    1385                 1390                 1395             


Ser Leu  His Phe Pro Arg Ile  Gln Glu Gly Asp Ser  Gly Leu Tyr 
    1400                 1405                 1410             


Ser Cys  Arg Ala Glu Asn Gln  Ala Gly Thr Ala Gln  Arg Asp Phe 
    1415                 1420                 1425             


His Leu  Leu Val Leu Thr Pro  Pro Ser Val Leu Gly  Ala Gly Ala 
    1430                 1435                 1440             


Ala Gln  Glu Val Leu Gly Leu  Ala Gly Ala Asp Val  Glu Leu Gln 
    1445                 1450                 1455             


Cys Trp  Thr Ser Gly Val Pro  Thr Pro Gln Val Glu  Trp Thr Lys 
    1460                 1465                 1470             


Asp Arg  Gln Pro Val Leu Pro  Gly Gly Pro His Leu  Gln Val Gln 
    1475                 1480                 1485             


Glu Asp  Gly Gln Val Leu Arg  Ile Thr Gly Ser His  Val Gly Asp 
    1490                 1495                 1500             


Glu Gly  Arg Tyr Gln Cys Val  Ala Phe Ser Pro Ala  Gly Gln Gln 
    1505                 1510                 1515             


Ala Arg  Asp Phe Gln Leu Arg  Val His Ala Pro Pro  Thr Ile Trp 
    1520                 1525                 1530             


Gly Ser  Asn Glu Thr Gly Glu  Val Ala Val Met Glu  Asp His Leu 
    1535                 1540                 1545             


Val Gln  Leu Leu Cys Glu Ala  Arg Gly Val Pro Thr  Pro Asn Ile 
    1550                 1555                 1560             


Thr Trp  Phe Lys Asp Gly Ala  Leu Leu Pro Thr Ser  Thr Lys Val 
    1565                 1570                 1575             


Val Tyr  Thr Arg Gly Gly Arg  Gln Leu Gln Leu Gly  Arg Ala Gln 
    1580                 1585                 1590             


Ser Ser  Asp Ala Gly Val Tyr  Thr Cys Lys Ala Ser  Asn Ala Val 
    1595                 1600                 1605             


Gly Ala  Ala Glu Lys Ala Thr  Arg Leu Asp Val Tyr  Val Pro Pro 
    1610                 1615                 1620             


Thr Ile  Glu Gly Ala Gly Gly  Arg Pro Tyr Val Val  Lys Ala Val 
    1625                 1630                 1635             


Ala Gly  Arg Pro Val Ala Leu  Glu Cys Val Ala Arg  Gly His Pro 
    1640                 1645                 1650             


Ser Pro  Thr Leu Ser Trp His  His Glu Gly Leu Pro  Val Ala Glu 
    1655                 1660                 1665             


Ser Asn  Glu Ser Arg Leu Glu  Thr Asp Gly Ser Val  Leu Arg Leu 
    1670                 1675                 1680             


Glu Ser  Pro Gly Glu Ala Ser  Ser Gly Leu Tyr Ser  Cys Val Ala 
    1685                 1690                 1695             


Ser Ser  Pro Ala Gly Glu Ala  Val Leu Gln Tyr Ser  Val Glu Val 
    1700                 1705                 1710             


Gln Val  Pro Pro Gln Leu Leu  Val Ala Glu Gly Leu  Gly Gln Val 
    1715                 1720                 1725             


Thr Thr  Ile Val Gly Gln Pro  Leu Glu Leu Pro Cys  Gln Ala Ser 
    1730                 1735                 1740             


Gly Ser  Pro Val Pro Thr Ile  Gln Trp Leu Gln Asn  Gly Arg Pro 
    1745                 1750                 1755             


Ala Glu  Glu Leu Ala Gly Val  Gln Val Ala Ser Gln  Gly Thr Thr 
    1760                 1765                 1770             


Leu His  Ile Asp His Val Glu  Leu Asp His Ser Gly  Leu Phe Ala 
    1775                 1780                 1785             


Cys Gln  Ala Thr Asn Glu Ala  Gly Thr Ala Gly Ala  Glu Val Glu 
    1790                 1795                 1800             


Val Ser  Val His Glu Phe Pro  Ser Val Ser Ile Ile  Gly Gly Glu 
    1805                 1810                 1815             


Asn Ile  Thr Ala Pro Phe Leu  Gln Pro Val Thr Leu  Gln Cys Ile 
    1820                 1825                 1830             


Gly Asp  Gly Val Pro Thr Pro  Ser Leu Arg Trp Trp  Lys Asp Gly 
    1835                 1840                 1845             


Val Ala  Leu Ala Ala Phe Gly  Gly Asn Leu Gln Ile  Glu Lys Val 
    1850                 1855                 1860             


Asp Leu  Arg Asp Glu Gly Ile  Tyr Thr Cys Ala Ala  Thr Asn Leu 
    1865                 1870                 1875             


Ala Gly  Glu Ser Lys Arg Glu  Val Ala Leu Lys Val  Leu Val Pro 
    1880                 1885                 1890             


Pro Asn  Ile Glu Pro Gly Pro  Val Asn Lys Ala Val  Leu Glu Asn 
    1895                 1900                 1905             


Ala Ser  Val Thr Leu Glu Cys  Leu Ala Ser Gly Val  Pro Pro Pro 
    1910                 1915                 1920             


Asp Val  Ser Trp Phe Lys Gly  His Gln Pro Val Ser  Ser Trp Met 
    1925                 1930                 1935             


Gly Val  Thr Val Ser Val Asp  Gly Arg Val Leu Arg  Ile Glu Gln 
    1940                 1945                 1950             


Ala Gln  Leu Ser Asp Ala Gly  Ser Tyr Arg Cys Val  Ala Ser Asn 
    1955                 1960                 1965             


Val Ala  Gly Ser Thr Glu Leu  Arg Tyr Gly Leu Arg  Val Asn Val 
    1970                 1975                 1980             


Pro Pro  Arg Ile Thr Leu Pro  Pro Ser Leu Pro Gly  Pro Val Leu 
    1985                 1990                 1995             


Val Asn  Thr Pro Val Arg Leu  Thr Cys Asn Ala Thr  Gly Ala Pro 
    2000                 2005                 2010             


Ser Pro  Thr Leu Met Trp Leu  Lys Asp Gly Asn Pro  Val Ser Pro 
    2015                 2020                 2025             


Ala Gly  Thr Pro Gly Leu Gln  Val Phe Pro Gly Gly  Arg Val Leu 
    2030                 2035                 2040             


Thr Leu  Ala Ser Ala Arg Ala  Ser Asp Ser Gly Arg  Tyr Ser Cys 
    2045                 2050                 2055             


Val Ala  Val Ser Ala Val Gly  Glu Asp Arg Gln Asp  Val Val Leu 
    2060                 2065                 2070             


Gln Val  His Met Pro Pro Ser  Ile Leu Gly Glu Glu  Leu Asn Val 
    2075                 2080                 2085             


Ser Val  Val Ala Asn Glu Ser  Val Ala Leu Glu Cys  Gln Ser His 
    2090                 2095                 2100             


Ala Met  Pro Pro Pro Val Leu  Ser Trp Trp Lys Asp  Gly Arg Pro 
    2105                 2110                 2115             


Leu Glu  Pro Arg Pro Gly Val  His Leu Ser Ala Asp  Lys Ala Leu 
    2120                 2125                 2130             


Leu Gln  Val Asp Arg Ala Asp  Val Trp Asp Ala Gly  His Tyr Thr 
    2135                 2140                 2145             


Cys Glu  Ala Leu Asn Gln Ala  Gly His Ser Glu Lys  His Tyr Asn 
    2150                 2155                 2160             


Leu Asn  Val Trp Val Ala Pro  Val Phe Pro Leu Arg  Glu Ser His 
    2165                 2170                 2175             


Thr Leu  Thr Val Arg Glu Gly  His Pro Thr Arg Leu  Ser Cys Glu 
    2180                 2185                 2190             


Cys Arg  Gly Val Pro Phe Pro  Lys Ile Ser Trp Arg  Lys Asp Gly 
    2195                 2200                 2205             


Gln Pro  Leu Pro Gly Glu Gly  Ala Gly Leu Gln His  Val Ser Ala 
    2210                 2215                 2220             


Val Gly  Arg Leu Leu Tyr Leu  Gly Gln Ala Gln Leu  Ala Gln Glu 
    2225                 2230                 2235             


Gly Thr  Tyr Thr Cys Glu Cys  Ser Asn Val Val Gly  Asn Ser Ser 
    2240                 2245                 2250             


Gln Asp  Leu Gln Leu Glu Val  His Val Pro Pro Gln  Ile Ala Gly 
    2255                 2260                 2265             


Pro Arg  Glu Pro Pro Thr Gln  Val Ser Val Val Gln  Asp Gly Val 
    2270                 2275                 2280             


Ala Thr  Leu Glu Cys Asn Ala  Thr Gly Lys Pro Pro  Pro Thr Val 
    2285                 2290                 2295             


Thr Trp  Glu Arg Asp Gly Gln  Pro Val Gly Ala Glu  Leu Gly Leu 
    2300                 2305                 2310             


Gln Leu  Gln Asn Gln Gly Gln  Ser Leu His Val Glu  Arg Ala Gln 
    2315                 2320                 2325             


Ala Ala  His Thr Gly Arg Tyr  Ser Cys Val Ala Glu  Asn Leu Ala 
    2330                 2335                 2340             


Gly Arg  Ala Glu Arg Lys Phe  Glu Leu Ser Val Leu  Val Pro Pro 
    2345                 2350                 2355             


Glu Leu  Ile Gly Asp Leu Asp  Pro Leu Thr Asn Ile  Thr Ala Ala 
    2360                 2365                 2370             


Leu His  Ser Pro Leu Thr Leu  Leu Cys Glu Ala Met  Gly Ile Pro 
    2375                 2380                 2385             


Pro Pro  Ala Ile Arg Trp Phe  Arg Gly Glu Glu Pro  Val Ser Pro 
    2390                 2395                 2400             


Gly Glu  Asp Thr Tyr Leu Leu  Ala Gly Gly Trp Met  Leu Lys Met 
    2405                 2410                 2415             


Thr Gln  Thr Gln Glu Gln Asp  Ser Gly Leu Tyr Ser  Cys Leu Ala 
    2420                 2425                 2430             


Ser Asn  Glu Ala Gly Glu Ala  Arg Arg Asn Phe Ser  Val Glu Val 
    2435                 2440                 2445             


Leu Val  Pro Pro Ser Ile Glu  Asn Glu Asp Leu Glu  Glu Val Ile 
    2450                 2455                 2460             


Lys Val  Leu Asp Gly Gln Thr  Ala His Leu Met Cys  Asn Val Thr 
    2465                 2470                 2475             


Gly His  Pro Gln Pro Lys Leu  Thr Trp Phe Lys Asp  Gly Arg Pro 
    2480                 2485                 2490             


Leu Ala  Arg Gly Asp Ala His  His Ile Ser Pro Asp  Gly Val Leu 
    2495                 2500                 2505             


Leu Gln  Val Leu Gln Ala Asn  Leu Ser Ser Ala Gly  His Tyr Ser 
    2510                 2515                 2520             


Cys Ile  Ala Ala Asn Ala Val  Gly Glu Lys Thr Lys  His Phe Gln 
    2525                 2530                 2535             


Leu Ser  Val Leu Leu Ala Pro  Thr Ile Leu Gly Gly  Ala Glu Asp 
    2540                 2545                 2550             


Ser Ala  Asp Glu Glu Val Thr  Val Thr Val Asn Asn  Pro Ile Ser 
    2555                 2560                 2565             


Leu Ile  Cys Glu Ala Leu Ala  Phe Pro Ser Pro Asn  Ile Thr Trp 
    2570                 2575                 2580             


Met Lys  Asp Gly Ala Pro Phe  Glu Ala Ser Arg Asn  Ile Gln Leu 
    2585                 2590                 2595             


Leu Pro  Gly Thr His Gly Leu  Gln Ile Leu Asn Ala  Gln Lys Glu 
    2600                 2605                 2610             


Asp Ala  Gly Gln Tyr Thr Cys  Val Val Thr Asn Glu  Leu Gly Glu 
    2615                 2620                 2625             


Ala Val  Lys Asn Tyr His Val  Glu Val Leu Ile Pro  Pro Ser Ile 
    2630                 2635                 2640             


Ser Lys  Asp Asp Pro Leu Ala  Glu Val Gly Val Lys  Glu Val Lys 
    2645                 2650                 2655             


Thr Lys  Val Asn Ser Thr Leu  Thr Leu Glu Cys Glu  Ser Trp Ala 
    2660                 2665                 2670             


Val Pro  Pro Pro Thr Ile Arg  Trp Tyr Lys Asp Gly  Gln Pro Val 
    2675                 2680                 2685             


Thr Pro  Ser Ser Arg Leu Gln  Val Leu Gly Glu Gly  Arg Leu Leu 
    2690                 2695                 2700             


Gln Ile  Gln Pro Thr Gln Val  Ser Asp Ser Gly Arg  Tyr Leu Cys 
    2705                 2710                 2715             


Val Ala  Thr Asn Val Ala Gly  Glu Asp Asp Gln Asp  Phe Asn Val 
    2720                 2725                 2730             


Leu Ile  Gln Val Pro Pro Met  Phe Gln Lys Val Gly  Asp Phe Ser 
    2735                 2740                 2745             


Ala Ala  Phe Glu Ile Leu Ser  Arg Glu Glu Glu Ala  Arg Gly Gly 
    2750                 2755                 2760             


Val Thr  Glu Tyr Arg Glu Ile  Val Glu Asn Asn Pro  Ala Tyr Leu 
    2765                 2770                 2775             


Tyr Cys  Asp Thr Asn Ala Ile  Pro Pro Pro Asp Leu  Thr Trp Tyr 
    2780                 2785                 2790             


Arg Glu  Asp Gln Pro Leu Ser  Ala Gly Asp Glu Val  Ser Val Leu 
    2795                 2800                 2805             


Gln Gly  Gly Arg Val Leu Gln  Ile Pro Leu Val Arg  Ala Glu Asn 
    2810                 2815                 2820             


Ala Gly  Arg Tyr Ser Cys Lys  Ala Ser Asn Glu Val  Gly Glu Asp 
    2825                 2830                 2835             


Trp Leu  His Tyr Glu Leu Leu  Val Leu Thr Pro Pro  Val Ile Leu 
    2840                 2845                 2850             


Gly Asp  Thr Glu Glu Leu Val  Glu Glu Val Thr Val  Asn Ala Ser 
    2855                 2860                 2865             


Ser Thr  Val Ser Leu Gln Cys  Pro Ala Leu Gly Asn  Pro Val Pro 
    2870                 2875                 2880             


Thr Ile  Ser Trp Leu Gln Asn  Gly Leu Pro Phe Ser  Pro Ser Pro 
    2885                 2890                 2895             


Arg Leu  Gln Val Leu Glu Asp  Gly Gln Val Leu Gln  Val Ser Thr 
    2900                 2905                 2910             


Ala Glu  Val Ala Asp Ala Ala  Ser Tyr Met Cys Val  Ala Glu Asn 
    2915                 2920                 2925             


Gln Ala  Gly Ser Ala Glu Lys  Leu Phe Thr Leu Arg  Val Gln Val 
    2930                 2935                 2940             


Pro Pro  Arg Ile Ala Gly Leu  Asp Leu Glu Gln Val  Thr Ala Ile 
    2945                 2950                 2955             


Leu Asn  Ser Ser Val Ser Leu  Pro Cys Asp Val His  Ala His Pro 
    2960                 2965                 2970             


Asn Pro  Glu Val Thr Trp Tyr  Lys Asp Ser Gln Ala  Leu Ser Leu 
    2975                 2980                 2985             


Gly Glu  Glu Val Phe Leu Leu  Pro Gly Thr His Thr  Leu Gln Leu 
    2990                 2995                 3000             


Gly Arg  Ala Arg Leu Ser Asp  Ser Gly Met Tyr Thr  Cys Glu Ala 
    3005                 3010                 3015             


Leu Asn  Ala Ala Gly Arg Asp  Gln Lys Leu Val Gln  Leu Ser Val 
    3020                 3025                 3030             


Leu Val  Pro Pro Ala Phe Arg  Gln Ala Pro Arg Gly  Pro Gln Asp 
    3035                 3040                 3045             


Ala Val  Leu Val Arg Val Gly  Asp Lys Ala Val Leu  Ser Cys Glu 
    3050                 3055                 3060             


Thr Asp  Ala Leu Pro Glu Pro  Thr Val Thr Trp Tyr  Lys Asp Gly 
    3065                 3070                 3075             


Gln Pro  Leu Val Leu Ala Gln  Arg Thr Gln Ala Leu  Arg Gly Gly 
    3080                 3085                 3090             


Gln Arg  Leu Glu Ile Gln Glu  Ala Gln Val Ser Asp  Lys Gly Leu 
    3095                 3100                 3105             


Tyr Ser  Cys Lys Val Ser Asn  Val Ala Gly Glu Ala  Val Arg Thr 
    3110                 3115                 3120             


Phe Thr  Leu Thr Val Gln Val  Pro Pro Thr Phe Glu  Asn Pro Lys 
    3125                 3130                 3135             


Thr Glu  Thr Val Ser Gln Val  Ala Gly Ser Pro Leu  Val Leu Thr 
    3140                 3145                 3150             


Cys Asp  Val Ser Gly Val Pro  Ala Pro Thr Val Thr  Trp Leu Lys 
    3155                 3160                 3165             


Asp Arg  Met Pro Val Glu Ser  Ser Ala Val His Gly  Val Val Ser 
    3170                 3175                 3180             


Arg Gly  Gly Arg Leu Gln Leu  Ser Arg Leu Gln Pro  Ala Gln Ala 
    3185                 3190                 3195             


Gly Thr  Tyr Thr Cys Val Ala  Glu Asn Thr Gln Ala  Glu Ala Arg 
    3200                 3205                 3210             


Lys Asp  Phe Val Val Ala Val  Leu Val Ala Pro Arg  Ile Arg Ser 
    3215                 3220                 3225             


Ser Gly  Val Ala Arg Glu His  His Val Leu Glu Gly  Gln Glu Val 
    3230                 3235                 3240             


Arg Leu  Asp Cys Glu Ala Asp  Gly Gln Pro Pro Pro  Asp Val Ala 
    3245                 3250                 3255             


Trp Leu  Lys Asp Gly Ser Pro  Leu Gly Gln Asp Met  Gly Pro His 
    3260                 3265                 3270             


Leu Arg  Phe Tyr Leu Asp Gly  Gly Ser Leu Val Leu  Lys Gly Leu 
    3275                 3280                 3285             


Arg Ala  Ser Asp Ala Gly Ala  Tyr Thr Cys Val Ala  His Asn Pro 
    3290                 3295                 3300             


Ala Gly  Glu Asp Ala Arg Leu  His Thr Val Asn Val  Leu Val Pro 
    3305                 3310                 3315             


Pro Thr  Ile Lys Gln Gly Ala  Asp Gly Ser Gly Thr  Leu Val Ser 
    3320                 3325                 3330             


Arg Pro  Gly Glu Leu Val Thr  Met Val Cys Pro Val  Arg Gly Ser 
    3335                 3340                 3345             


Pro Pro  Ile His Val Ser Trp  Leu Lys Asp Gly Leu  Pro Leu Pro 
    3350                 3355                 3360             


Leu Ser  Gln Arg Thr Leu Leu  His Gly Ser Gly His  Thr Leu Arg 
    3365                 3370                 3375             


Ile Ser  Lys Val Gln Leu Ala  Asp Ala Gly Ile Phe  Thr Cys Val 
    3380                 3385                 3390             


Ala Ala  Ser Pro Ala Gly Val  Ala Asp Arg Asn Phe  Thr Leu Gln 
    3395                 3400                 3405             


Val Gln  Val Pro Pro Val Leu  Glu Pro Val Glu Phe  Gln Asn Asp 
    3410                 3415                 3420             


Val Val  Val Val Arg Gly Ser  Leu Val Glu Leu Pro  Cys Glu Ala 
    3425                 3430                 3435             


Arg Gly  Val Pro Leu Pro Leu  Val Ser Trp Met Lys  Asp Gly Glu 
    3440                 3445                 3450             


Pro Leu  Leu Ser Gln Ser Leu  Glu Gln Gly Pro Ser  Leu Gln Leu 
    3455                 3460                 3465             


Glu Ala  Val Gly Ala Gly Asp  Ser Gly Thr Tyr Ser  Cys Val Ala 
    3470                 3475                 3480             


Val Ser  Glu Ala Gly Glu Ala  Arg Arg His Phe Gln  Leu Thr Val 
    3485                 3490                 3495             


Met Glu  Pro Pro His Ile Glu  Asp Ser Gly Gln Pro  Thr Glu Leu 
    3500                 3505                 3510             


Ser Leu  Thr Pro Gly Ala Pro  Met Glu Leu Leu Cys  Asp Ala Gln 
    3515                 3520                 3525             


Gly Thr  Pro Gln Pro Asn Ile  Thr Trp His Lys Asp  Gly Gln Ala 
    3530                 3535                 3540             


Leu Thr  Arg Leu Glu Asn Asn  Ser Arg Ala Thr Arg  Val Leu Arg 
    3545                 3550                 3555             


Val Glu  Asn Val Gln Val Arg  Asp Ala Gly Leu Tyr  Thr Cys Leu 
    3560                 3565                 3570             


Ala Glu  Ser Pro Ala Gly Ala  Ile Glu Lys Ser Phe  Arg Val Arg 
    3575                 3580                 3585             


Val Gln  Ala Pro Pro Asn Ile  Val Gly Pro Arg Gly  Pro Arg Phe 
    3590                 3595                 3600             


Val Val  Gly Leu Ala Pro Gly  Gln Leu Val Leu Glu  Cys Ser Val 
    3605                 3610                 3615             


Glu Ala  Glu Pro Ala Pro Lys  Ile Thr Trp His Arg  Asp Gly Ile 
    3620                 3625                 3630             


Val Leu  Gln Glu Asp Ala His  Thr Gln Phe Pro Glu  Arg Gly Arg 
    3635                 3640                 3645             


Phe Leu  Gln Leu Gln Ala Leu  Ser Thr Ala Asp Ser  Gly Asp Tyr 
    3650                 3655                 3660             


Ser Cys  Thr Ala Arg Asn Ala  Ala Gly Ser Thr Ser  Val Ala Phe 
    3665                 3670                 3675             


Arg Val  Glu Ile His Thr Val  Pro Thr Ile Arg Ser  Gly Pro Pro 
    3680                 3685                 3690             


Ala Val  Asn Val Ser Val Asn  Gln Thr Ala Leu Leu  Pro Cys Gln 
    3695                 3700                 3705             


Ala Asp  Gly Val Pro Ala Pro  Leu Val Ser Trp Arg  Lys Asp Arg 
    3710                 3715                 3720             


Val Pro  Leu Asp Pro Arg Ser  Pro Arg Phe Glu Ile  Leu Pro Glu 
    3725                 3730                 3735             


Gly Ser  Leu Arg Ile Gln Pro  Val Leu Ala Gln Asp  Ala Gly His 
    3740                 3745                 3750             


Tyr Leu  Cys Leu Ala Ser Asn  Ser Ala Gly Ser Asp  Arg Gln Gly 
    3755                 3760                 3765             


Arg Asp  Leu Arg Val Leu Ala  Leu Leu Pro Cys Glu  Ala Ser Gly 
    3770                 3775                 3780             


Ser Pro  Lys Pro Leu Val Val  Trp Trp Lys Asp Gly  Gln Lys Leu 
    3785                 3790                 3795             


Asp Phe  Arg Leu Gln Gln Gly  Ala Tyr Arg Leu Leu  Pro Ser Asn 
    3800                 3805                 3810             


Ala Leu  Leu Leu Thr Ala Pro  Gly Pro Gln Asp Ser  Ala Gln Phe 
    3815                 3820                 3825             


Glu Cys  Val Val Ser Asn Glu  Val Gly Glu Ala His  Arg Leu Tyr 
    3830                 3835                 3840             


Gln Val  Thr Val His Val Pro  Pro Thr Ile Ala Asp  Asp Gln Thr 
    3845                 3850                 3855             


Asp Phe  Thr Val Thr Met Met  Ala Pro Val Val Leu  Thr Cys His 
    3860                 3865                 3870             


Ser Thr  Gly Ile Pro Ala Pro  Thr Val Ser Trp Ser  Lys Ala Gly 
    3875                 3880                 3885             


Ala Gln  Leu Gly Ala Arg Gly  Ser Gly Tyr Arg Val  Ser Pro Ser 
    3890                 3895                 3900             


Gly Ala  Leu Glu Ile Gly Gln  Ala Leu Pro Ile His  Ala Gly Arg 
    3905                 3910                 3915             


Tyr Thr  Cys Ser Ala Arg Asn  Ser Ala Gly Val Ala  His Lys His 
    3920                 3925                 3930             


Val Phe  Leu Thr Val Gln Ala  Ser Pro Val Val Lys  Pro Leu Pro 
    3935                 3940                 3945             


Ser Val  Val Arg Ala Val Ala  Glu Glu Glu Val Leu  Leu Pro Cys 
    3950                 3955                 3960             


Glu Ala  Ser Gly Ile Pro Arg  Pro Thr Ile Thr Trp  Gln Lys Glu 
    3965                 3970                 3975             


Gly Leu  Asn Val Ala Thr Gly  Val Ser Thr Gln Val  Leu Pro Gly 
    3980                 3985                 3990             


Gly Gln  Leu Arg Ile Ala His  Ala Ser Pro Glu Asp  Ala Gly Asn 
    3995                 4000                 4005             


Tyr Leu  Cys Ile Ala Lys Asn  Ser Ala Gly Ser Ala  Met Gly Lys 
    4010                 4015                 4020             


Thr Arg  Leu Val Val Gln Val  Pro Pro Val Ile Glu  Asn Gly Leu 
    4025                 4030                 4035             


Pro Asp  Leu Ser Thr Thr Glu  Gly Ser His Ala Phe  Leu Pro Cys 
    4040                 4045                 4050             


Lys Ala  Arg Gly Ser Pro Glu  Pro Asn Ile Thr Trp  Asp Lys Asp 
    4055                 4060                 4065             


Gly Gln  Pro Val Ser Gly Ala  Glu Gly Lys Phe Thr  Ile Gln Pro 
    4070                 4075                 4080             


Ser Gly  Glu Leu Leu Val Lys  Asn Leu Glu Gly Gln  Asp Ala Gly 
    4085                 4090                 4095             


Thr Tyr  Thr Cys Thr Ala Glu  Asn Ala Val Gly Arg  Ala Arg Arg 
    4100                 4105                 4110             


Arg Val  His Leu Thr Ile Leu  Val Leu Pro Val Phe  Thr Thr Leu 
    4115                 4120                 4125             


Pro Gly  Asp Arg Ser Leu Arg  Leu Gly Asp Arg Leu  Trp Leu Arg 
    4130                 4135                 4140             


Cys Ala  Ala Arg Gly Ser Pro  Thr Pro Arg Ile Gly  Trp Thr Val 
    4145                 4150                 4155             


Asn Asp  Arg Pro Val Thr Glu  Gly Val Ser Glu Gln  Asp Gly Gly 
    4160                 4165                 4170             


Ser Thr  Leu Gln Arg Ala Ala  Val Ser Arg Glu Asp  Ser Gly Thr 
    4175                 4180                 4185             


Tyr Val  Cys Trp Ala Glu Asn  Arg Val Gly Arg Thr  Gln Ala Val 
    4190                 4195                 4200             


Ser Phe  Val His Val Lys Glu  Ala Pro Val Leu Gln  Gly Glu Ala 
    4205                 4210                 4215             


Phe Ser  Tyr Leu Val Glu Pro  Val Gly Gly Ser Ile  Gln Leu Asp 
    4220                 4225                 4230             


Cys Val  Val Arg Gly Asp Pro  Val Pro Asp Ile His  Trp Ile Lys 
    4235                 4240                 4245             


Asp Gly  Leu Pro Leu Arg Gly  Ser His Leu Arg His  Gln Leu Gln 
    4250                 4255                 4260             


Asn Gly  Ser Leu Thr Ile Arg  Arg Thr Glu Arg Asp  Asp Ala Gly 
    4265                 4270                 4275             


Arg Tyr  Gln Cys Leu Ala Glu  Asn Glu Met Gly Val  Ala Lys Lys 
    4280                 4285                 4290             


Val Val  Ile Leu Val Leu Gln  Ser Ala Pro Val Phe  Gln Val Glu 
    4295                 4300                 4305             


Pro Gln  Asp Met Thr Val Arg  Ser Gly Asp Asp Val  Ala Leu Arg 
    4310                 4315                 4320             


Cys Gln  Ala Thr Gly Glu Pro  Thr Pro Thr Ile Glu  Trp Leu Gln 
    4325                 4330                 4335             


Ala Gly  Gln Pro Leu Arg Ala  Ser Arg Arg Leu Arg  Thr Leu Pro 
    4340                 4345                 4350             


Asp Gly  Ser Leu Trp Leu Glu  Asn Val Glu Thr Gly  Asp Ala Gly 
    4355                 4360                 4365             


Thr Tyr  Asp Cys Val Ala His  Asn Leu Leu Gly Ser  Ala Thr Ala 
    4370                 4375                 4380             


Arg Ala  Phe Leu Val Val Arg  Gly Glu Pro Gln Gly  Ser Trp Gly 
    4385                 4390                 4395             


Ser Met  Thr Gly Val Ile Asn  Gly Arg Lys Phe Gly  Val Ala Thr 
    4400                 4405                 4410             


Leu Asn  Thr Ser Val Met Gln  Glu Ala His Ser Gly  Val Ser Ser 
    4415                 4420                 4425             


Ile His  Ser Ser Ile Arg His  Val Pro Ala Asn Val  Gly Pro Leu 
    4430                 4435                 4440             


Met Arg  Val Leu Val Val Thr  Ile Ala Pro Ile Tyr  Trp Ala Leu 
    4445                 4450                 4455             


Ala Arg  Glu Ser Gly Glu Ala  Leu Asn Gly His Ser  Leu Thr Gly 
    4460                 4465                 4470             


Gly Arg  Phe Arg Gln Glu Ser  His Val Glu Phe Ala  Thr Gly Glu 
    4475                 4480                 4485             


Leu Leu  Thr Met Thr Gln Val  Ala Arg Gly Leu Asp  Pro Asp Gly 
    4490                 4495                 4500             


Leu Leu  Leu Leu Asp Val Val  Val Asn Gly Val Val  Pro Glu Ser 
    4505                 4510                 4515             


Leu Ala  Asp Ala Asp Leu Gln  Val Gln Asp Phe Glu  Glu His Tyr 
    4520                 4525                 4530             


Val Gln  Thr Gly Pro Gly Gln  Leu Phe Val Gly Ser  Thr Gln Arg 
    4535                 4540                 4545             


Phe Phe  Gln Gly Gly Leu Pro  Ser Phe Leu Arg Cys  Asn His Ser 
    4550                 4555                 4560             


Ile Gln  Tyr Asn Ala Ala Arg  Gly Pro Gln Pro Gln  Leu Val Gln 
    4565                 4570                 4575             


His Leu  Arg Ala Ser Ala Ile  Ser Ser Ala Phe Asp  Pro Glu Ala 
    4580                 4585                 4590             


Glu Ala  Leu Arg Phe Gln Leu  Ala Thr Ala Leu Gln  Ala Glu Glu 
    4595                 4600                 4605             


Asn Glu  Val Gly Cys Pro Glu  Gly Phe Glu Leu Asp  Ser Gln Gly 
    4610                 4615                 4620             


Ala Phe  Cys Val Asp Arg Asp  Glu Cys Ser Gly Gly  Pro Ser Pro 
    4625                 4630                 4635             


Cys Ser  His Ala Cys Leu Asn  Ala Pro Gly Arg Phe  Ser Cys Thr 
    4640                 4645                 4650             


Cys Pro  Thr Gly Phe Ala Leu  Ala Trp Asp Asp Arg  Asn Cys Arg 
    4655                 4660                 4665             


Asp Val  Asp Glu Cys Ala Trp  Asp Ala His Leu Cys  Arg Glu Gly 
    4670                 4675                 4680             


Gln Arg  Cys Val Asn Leu Leu  Gly Ser Tyr Arg Cys  Leu Pro Asp 
    4685                 4690                 4695             


Cys Gly  Pro Gly Phe Arg Val  Ala Asp Gly Ala Gly  Cys Glu Asp 
    4700                 4705                 4710             


Val Asp  Glu Cys Leu Glu Gly  Leu Asp Asp Cys His  Tyr Asn Gln 
    4715                 4720                 4725             


Leu Cys  Glu Asn Thr Pro Gly  Gly His Arg Cys Ser  Cys Pro Arg 
    4730                 4735                 4740             


Gly Tyr  Arg Met Gln Gly Pro  Ser Leu Pro Cys Leu  Asp Val Asn 
    4745                 4750                 4755             


Glu Cys  Leu Gln Leu Pro Lys  Ala Cys Ala Tyr Gln  Cys His Asn 
    4760                 4765                 4770             


Leu Gln  Gly Ser Tyr Arg Cys  Leu Cys Pro Pro Gly  Gln Thr Leu 
    4775                 4780                 4785             


Leu Arg  Asp Gly Lys Ala Cys  Thr Ser Leu Glu Arg  Asn Gly Gln 
    4790                 4795                 4800             


Asn Val  Thr Thr Val Ser His  Arg Gly Pro Leu Leu  Pro Trp Leu 
    4805                 4810                 4815             


Arg Pro  Trp Ala Ser Ile Pro  Gly Thr Ser Tyr His  Ala Trp Val 
    4820                 4825                 4830             


Ser Leu  Arg Pro Gly Pro Met  Ala Leu Ser Ser Val  Gly Arg Ala 
    4835                 4840                 4845             


Trp Cys  Pro Pro Gly Phe Ile  Arg Gln Asn Gly Val  Cys Thr Asp 
    4850                 4855                 4860             


Leu Asp  Glu Cys Arg Val Arg  Asn Leu Cys Gln His  Ala Cys Arg 
    4865                 4870                 4875             


Asn Thr  Glu Gly Ser Tyr Gln  Cys Leu Cys Pro Ala  Gly Tyr Arg 
    4880                 4885                 4890             


Leu Leu  Pro Ser Gly Lys Asn  Cys Gln Asp Ile Asn  Glu Cys Glu 
    4895                 4900                 4905             


Glu Glu  Ser Ile Glu Cys Gly  Pro Gly Gln Met Cys  Phe Asn Thr 
    4910                 4915                 4920             


Arg Gly  Ser Tyr Gln Cys Val  Asp Thr Pro Cys Pro  Ala Thr Tyr 
    4925                 4930                 4935             


Arg Gln  Gly Pro Ser Pro Gly  Thr Cys Phe Arg Arg  Cys Ser Gln 
    4940                 4945                 4950             


Asp Cys  Gly Thr Gly Gly Pro  Ser Thr Leu Gln Tyr  Arg Leu Leu 
    4955                 4960                 4965             


Pro Leu  Pro Leu Gly Val Arg  Ala His His Asp Val  Ala Arg Leu 
    4970                 4975                 4980             


Thr Ala  Phe Ser Glu Val Gly  Val Pro Ala Asn Arg  Thr Glu Leu 
    4985                 4990                 4995             


Ser Met  Leu Glu Pro Asp Pro  Arg Ser Pro Phe Ala  Leu Arg Pro 
    5000                 5005                 5010             


Leu Arg  Ala Gly Leu Gly Ala  Val Tyr Thr Arg Arg  Ala Leu Thr 
    5015                 5020                 5025             


Arg Ala  Gly Leu Tyr Arg Leu  Thr Val Arg Ala Ala  Ala Pro Arg 
    5030                 5035                 5040             


His Gln  Ser Val Phe Val Leu  Leu Ile Ala Val Ser  Pro Tyr Pro 
    5045                 5050                 5055             


Tyr 
    


<210>  99
<211>  1299
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q6P4R8
<309>  2016-09-07
<313>  (1)..(1299)

<400>  99

Met Asp Ser Leu Asp His Met Leu Thr Asp Pro Leu Glu Leu Gly Pro 
1               5                   10                  15      


Cys Gly Asp Gly His Gly Thr Arg Ile Met Glu Asp Cys Leu Leu Gly 
            20                  25                  30          


Gly Thr Arg Val Ser Leu Pro Glu Asp Leu Leu Glu Asp Pro Glu Ile 
        35                  40                  45              


Phe Phe Asp Val Val Ser Leu Ser Thr Trp Gln Glu Val Leu Ser Asp 
    50                  55                  60                  


Ser Gln Arg Glu His Leu Gln Gln Phe Leu Pro Gln Phe Pro Glu Asp 
65                  70                  75                  80  


Ser Ala Glu Gln Gln Asn Glu Leu Ile Leu Ala Leu Phe Ser Gly Glu 
                85                  90                  95      


Asn Phe Arg Phe Gly Asn Pro Leu His Ile Ala Gln Lys Leu Phe Arg 
            100                 105                 110         


Asp Gly His Phe Asn Pro Glu Val Val Lys Tyr Arg Gln Leu Cys Phe 
        115                 120                 125             


Lys Ser Gln Tyr Lys Arg Tyr Leu Asn Ser Gln Gln Gln Tyr Phe His 
    130                 135                 140                 


Arg Leu Leu Lys Gln Ile Leu Ala Ser Arg Ser Asp Leu Leu Glu Met 
145                 150                 155                 160 


Ala Arg Arg Ser Gly Pro Ala Leu Pro Phe Arg Gln Lys Arg Pro Ser 
                165                 170                 175     


Pro Ser Arg Thr Pro Glu Glu Arg Glu Trp Arg Thr Gln Gln Arg Tyr 
            180                 185                 190         


Leu Lys Val Leu Arg Glu Val Lys Glu Glu Cys Gly Asp Thr Ala Leu 
        195                 200                 205             


Ser Ser Asp Glu Glu Asp Leu Ser Ser Trp Leu Pro Ser Ser Pro Ala 
    210                 215                 220                 


Arg Ser Pro Ser Pro Ala Val Pro Leu Arg Val Val Pro Thr Leu Ser 
225                 230                 235                 240 


Thr Thr Asp Met Lys Thr Ala Asp Lys Val Glu Leu Gly Asp Ser Asp 
                245                 250                 255     


Leu Lys Ile Met Leu Lys Lys His His Glu Lys Arg Lys His Gln Pro 
            260                 265                 270         


Asp His Pro Asp Leu Leu Thr Gly Asp Leu Thr Leu Asn Asp Ile Met 
        275                 280                 285             


Thr Arg Val Asn Ala Gly Arg Lys Gly Ser Leu Ala Ala Leu Tyr Asp 
    290                 295                 300                 


Leu Ala Val Leu Lys Lys Lys Val Lys Glu Lys Glu Glu Lys Lys Lys 
305                 310                 315                 320 


Lys Lys Ile Lys Thr Ile Lys Ser Glu Ala Glu Asp Leu Ala Glu Pro 
                325                 330                 335     


Leu Ser Ser Thr Glu Gly Val Ala Pro Leu Ser Gln Ala Pro Ser Pro 
            340                 345                 350         


Leu Ala Ile Pro Ala Ile Lys Glu Glu Pro Leu Glu Asp Leu Lys Pro 
        355                 360                 365             


Cys Leu Gly Ile Asn Glu Ile Ser Ser Ser Phe Phe Ser Leu Leu Leu 
    370                 375                 380                 


Glu Ile Leu Leu Leu Glu Ser Gln Ala Ser Leu Pro Met Leu Glu Glu 
385                 390                 395                 400 


Arg Val Leu Asp Trp Gln Ser Ser Pro Ala Ser Ser Leu Asn Ser Trp 
                405                 410                 415     


Phe Ser Ala Ala Pro Asn Trp Ala Glu Leu Val Leu Pro Ala Leu Gln 
            420                 425                 430         


Tyr Leu Ala Gly Glu Ser Arg Ala Val Pro Ser Ser Phe Ser Pro Phe 
        435                 440                 445             


Val Glu Phe Lys Glu Lys Thr Gln Gln Trp Lys Leu Leu Gly Gln Ser 
    450                 455                 460                 


Gln Asp Asn Glu Lys Glu Leu Ala Ala Leu Phe Gln Leu Trp Leu Glu 
465                 470                 475                 480 


Thr Lys Asp Gln Ala Phe Cys Lys Gln Glu Asn Glu Asp Ser Ser Asp 
                485                 490                 495     


Ala Thr Thr Pro Val Pro Arg Val Arg Thr Asp Tyr Val Val Arg Pro 
            500                 505                 510         


Ser Thr Gly Glu Glu Lys Arg Val Phe Gln Glu Gln Glu Arg Tyr Arg 
        515                 520                 525             


Tyr Ser Gln Pro His Lys Ala Phe Thr Phe Arg Met His Gly Phe Glu 
    530                 535                 540                 


Ser Val Val Gly Pro Val Lys Gly Val Phe Asp Lys Glu Thr Ser Leu 
545                 550                 555                 560 


Asn Lys Ala Arg Glu His Ser Leu Leu Arg Ser Asp Arg Pro Ala Tyr 
                565                 570                 575     


Val Thr Ile Leu Ser Leu Val Arg Asp Ala Ala Ala Arg Leu Pro Asn 
            580                 585                 590         


Gly Glu Gly Thr Arg Ala Glu Ile Cys Glu Leu Leu Lys Asp Ser Gln 
        595                 600                 605             


Phe Leu Ala Pro Asp Val Thr Ser Thr Gln Val Asn Thr Val Val Ser 
    610                 615                 620                 


Gly Ala Leu Asp Arg Leu His Tyr Glu Lys Asp Pro Cys Val Lys Tyr 
625                 630                 635                 640 


Asp Ile Gly Arg Lys Leu Trp Ile Tyr Leu His Arg Asp Arg Ser Glu 
                645                 650                 655     


Glu Glu Phe Glu Arg Ile His Gln Ala Gln Ala Ala Ala Ala Lys Ala 
            660                 665                 670         


Arg Lys Ala Leu Gln Gln Lys Pro Lys Pro Pro Ser Lys Val Lys Ser 
        675                 680                 685             


Ser Ser Lys Glu Ser Ser Ile Lys Val Leu Ser Ser Gly Pro Ser Glu 
    690                 695                 700                 


Gln Ser Gln Met Ser Leu Ser Asp Ser Ser Met Pro Pro Thr Pro Val 
705                 710                 715                 720 


Thr Pro Val Thr Pro Thr Thr Pro Ala Leu Pro Ala Ile Pro Ile Ser 
                725                 730                 735     


Pro Pro Pro Val Ser Ala Val Asn Lys Ser Gly Pro Ser Thr Val Ser 
            740                 745                 750         


Glu Pro Ala Lys Ser Ser Ser Gly Val Leu Leu Val Ser Ser Pro Thr 
        755                 760                 765             


Met Pro His Leu Gly Thr Met Leu Ser Pro Ala Ser Ser Gln Thr Ala 
    770                 775                 780                 


Pro Ser Ser Gln Ala Ala Ala Arg Val Val Ser His Ser Gly Ser Ala 
785                 790                 795                 800 


Gly Leu Ser Gln Val Arg Val Val Ala Gln Pro Ser Leu Pro Ala Val 
                805                 810                 815     


Pro Gln Gln Ser Gly Gly Pro Ala Gln Thr Leu Pro Gln Met Pro Ala 
            820                 825                 830         


Gly Pro Gln Ile Arg Val Pro Ala Thr Ala Thr Gln Thr Lys Val Val 
        835                 840                 845             


Pro Gln Thr Val Met Ala Thr Val Pro Val Lys Ala Gln Thr Thr Ala 
    850                 855                 860                 


Ala Thr Val Gln Arg Pro Gly Pro Gly Gln Thr Gly Leu Thr Val Thr 
865                 870                 875                 880 


Ser Leu Pro Ala Thr Ala Ser Pro Val Ser Lys Pro Ala Thr Ser Ser 
                885                 890                 895     


Pro Gly Thr Ser Ala Pro Ser Ala Ser Thr Ala Ala Val Ile Gln Asn 
            900                 905                 910         


Val Thr Gly Gln Asn Ile Ile Lys Gln Val Ala Ile Thr Gly Gln Leu 
        915                 920                 925             


Gly Val Lys Pro Gln Thr Gly Asn Ser Ile Pro Leu Thr Ala Thr Asn 
    930                 935                 940                 


Phe Arg Ile Gln Gly Lys Asp Val Leu Arg Leu Pro Pro Ser Ser Ile 
945                 950                 955                 960 


Thr Thr Asp Ala Lys Gly Gln Thr Val Leu Arg Ile Thr Pro Asp Met 
                965                 970                 975     


Met Ala Thr Leu Ala Lys Ser Gln Val Thr Thr Val Lys Leu Thr Gln 
            980                 985                 990         


Asp Leu Phe Gly Thr Gly Gly Asn  Thr Thr Gly Lys Gly  Ile Ser Ala 
        995                 1000                 1005             


Thr Leu  His Val Thr Ser Asn  Pro Val His Ala Ala  Asp Ser Pro 
    1010                 1015                 1020             


Ala Lys  Ala Ser Ser Ala Ser  Ala Pro Ser Ser Thr  Pro Thr Gly 
    1025                 1030                 1035             


Thr Thr  Val Val Lys Val Thr  Pro Asp Leu Lys Pro  Thr Glu Ala 
    1040                 1045                 1050             


Ser Ser  Ser Ala Phe Arg Leu  Met Pro Ala Leu Gly  Val Ser Val 
    1055                 1060                 1065             


Ala Asp  Gln Lys Gly Lys Ser  Thr Val Ala Ser Ser  Glu Ala Lys 
    1070                 1075                 1080             


Pro Ala  Ala Thr Ile Arg Ile  Val Gln Gly Leu Gly  Val Met Pro 
    1085                 1090                 1095             


Pro Lys  Ala Gly Gln Thr Ile  Thr Val Ala Thr His  Ala Lys Gln 
    1100                 1105                 1110             


Gly Ala  Ser Val Ala Ser Gly  Ser Gly Thr Val His  Thr Ser Ala 
    1115                 1120                 1125             


Val Ser  Leu Pro Ser Met Asn  Ala Ala Val Ser Lys  Thr Val Ala 
    1130                 1135                 1140             


Val Ala  Ser Gly Ala Ala Ser  Thr Pro Ile Ser Ile  Ser Thr Gly 
    1145                 1150                 1155             


Ala Pro  Thr Val Arg Gln Val  Pro Val Ser Thr Thr  Val Val Ser 
    1160                 1165                 1170             


Thr Ser  Gln Ala Gly Lys Leu  Pro Thr Arg Ile Thr  Val Pro Leu 
    1175                 1180                 1185             


Ser Val  Ile Ser Gln Pro Met  Lys Gly Lys Ser Val  Val Thr Ala 
    1190                 1195                 1200             


Pro Ile  Ile Lys Gly Asn Leu  Gly Ala Asn Leu Ser  Gly Leu Gly 
    1205                 1210                 1215             


Arg Asn  Ile Ile Leu Thr Thr  Met Pro Ala Gly Thr  Lys Leu Ile 
    1220                 1225                 1230             


Ala Gly  Asn Lys Pro Val Ser  Phe Leu Thr Ala Gln  Gln Leu Gln 
    1235                 1240                 1245             


Gln Leu  Gln Gln Gln Gly Gln  Ala Thr Gln Val Arg  Ile Gln Thr 
    1250                 1255                 1260             


Val Pro  Ala Ser His Leu Gln  Gln Gly Thr Ala Ser  Gly Ser Ser 
    1265                 1270                 1275             


Lys Ala  Val Ser Thr Val Val  Val Thr Thr Ala Pro  Ser Pro Lys 
    1280                 1285                 1290             


Gln Ala  Pro Glu Gln Gln 
    1295                 


<210>  100
<211>  1393
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / A3KN83
<309>  2008-01-29
<313>  (1)..(1393)

<400>  100

Met Val Glu Pro Gly Gln Asp Leu Leu Leu Ala Ala Leu Ser Glu Ser 
1               5                   10                  15      


Gly Ile Ser Pro Asn Asp Leu Phe Asp Ile Asp Gly Gly Asp Ala Gly 
            20                  25                  30          


Leu Ala Thr Pro Met Pro Thr Pro Ser Val Gln Gln Ser Val Pro Leu 
        35                  40                  45              


Ser Ala Leu Glu Leu Gly Leu Glu Thr Glu Ala Ala Val Pro Val Lys 
    50                  55                  60                  


Gln Glu Pro Glu Thr Val Pro Thr Pro Ala Leu Leu Asn Val Arg Gln 
65                  70                  75                  80  


Gln Pro Pro Ser Thr Thr Thr Phe Val Leu Asn Gln Ile Asn His Leu 
                85                  90                  95      


Pro Pro Leu Gly Ser Thr Ile Val Met Thr Lys Thr Pro Pro Val Thr 
            100                 105                 110         


Thr Asn Arg Gln Thr Ile Thr Leu Thr Lys Phe Ile Gln Thr Thr Ala 
        115                 120                 125             


Ser Thr Arg Pro Ser Val Ser Ala Pro Thr Val Arg Asn Ala Met Thr 
    130                 135                 140                 


Ser Ala Pro Ser Lys Asp Gln Val Gln Leu Lys Asp Leu Leu Lys Asn 
145                 150                 155                 160 


Asn Ser Leu Asn Glu Leu Met Lys Leu Lys Pro Pro Ala Asn Ile Ala 
                165                 170                 175     


Gln Pro Val Ala Thr Ala Ala Thr Asp Val Ser Asn Gly Thr Val Lys 
            180                 185                 190         


Lys Glu Ser Ser Asn Lys Glu Gly Ala Arg Met Trp Ile Asn Asp Met 
        195                 200                 205             


Lys Met Arg Ser Phe Ser Pro Thr Met Lys Val Pro Val Val Lys Glu 
    210                 215                 220                 


Asp Asp Glu Pro Glu Glu Glu Asp Glu Glu Glu Met Gly His Ala Glu 
225                 230                 235                 240 


Thr Tyr Ala Glu Tyr Met Pro Ile Lys Leu Lys Ile Gly Leu Arg His 
                245                 250                 255     


Pro Asp Ala Val Val Glu Thr Ser Ser Leu Ser Ser Val Thr Pro Pro 
            260                 265                 270         


Asp Val Trp Tyr Lys Thr Ser Ile Ser Glu Glu Thr Ile Asp Asn Gly 
        275                 280                 285             


Trp Leu Ser Ala Leu Gln Leu Glu Ala Ile Thr Tyr Ala Ala Gln Gln 
    290                 295                 300                 


His Glu Thr Phe Leu Pro Asn Gly Asp Arg Ala Gly Phe Leu Ile Gly 
305                 310                 315                 320 


Asp Gly Ala Gly Val Gly Lys Gly Arg Thr Ile Ala Gly Ile Ile Tyr 
                325                 330                 335     


Glu Asn Tyr Leu Leu Ser Arg Lys Arg Ala Leu Trp Phe Ser Val Ser 
            340                 345                 350         


Asn Asp Leu Lys Tyr Asp Ala Glu Arg Asp Leu Arg Asp Ile Gly Ala 
        355                 360                 365             


Lys Asn Ile Leu Val His Ser Leu Asn Lys Phe Lys Tyr Gly Lys Ile 
    370                 375                 380                 


Ser Ser Lys His Asn Gly Ser Val Lys Lys Gly Val Ile Phe Ala Thr 
385                 390                 395                 400 


Tyr Ser Ser Leu Ile Gly Glu Ser Gln Ser Gly Gly Lys Tyr Lys Thr 
                405                 410                 415     


Arg Leu Lys Gln Leu Leu His Trp Cys Gly Asp Asp Phe Asp Gly Val 
            420                 425                 430         


Ile Val Phe Asp Glu Cys His Lys Ala Lys Asn Leu Cys Pro Val Gly 
        435                 440                 445             


Ser Ser Lys Pro Thr Lys Thr Gly Leu Ala Val Leu Glu Leu Gln Asn 
    450                 455                 460                 


Lys Leu Pro Lys Ala Arg Val Val Tyr Ala Ser Ala Thr Gly Ala Ser 
465                 470                 475                 480 


Glu Pro Arg Asn Met Ala Tyr Met Asn Arg Leu Gly Ile Trp Gly Glu 
                485                 490                 495     


Gly Thr Pro Phe Arg Glu Phe Ser Asp Phe Ile Gln Ala Val Glu Arg 
            500                 505                 510         


Arg Gly Val Gly Ala Met Glu Ile Val Ala Met Asp Met Lys Leu Arg 
        515                 520                 525             


Gly Met Tyr Ile Ala Arg Gln Leu Ser Phe Thr Gly Val Thr Phe Lys 
    530                 535                 540                 


Ile Glu Glu Val Leu Leu Ser Gln Ser Tyr Val Lys Met Tyr Asn Lys 
545                 550                 555                 560 


Ala Val Lys Leu Trp Val Ile Ala Arg Glu Arg Phe Gln Gln Ala Ala 
                565                 570                 575     


Asp Leu Ile Asp Ala Glu Gln Arg Met Lys Lys Ser Met Trp Gly Gln 
            580                 585                 590         


Phe Trp Ser Ala His Gln Arg Phe Phe Lys Tyr Leu Cys Ile Ala Ser 
        595                 600                 605             


Lys Val Lys Arg Val Val Gln Leu Ala Arg Glu Glu Ile Lys Asn Gly 
    610                 615                 620                 


Lys Cys Val Val Ile Gly Leu Gln Ser Thr Gly Glu Ala Arg Thr Leu 
625                 630                 635                 640 


Glu Ala Leu Glu Glu Gly Gly Gly Glu Leu Asn Asp Phe Val Ser Thr 
                645                 650                 655     


Ala Lys Gly Val Leu Gln Ser Leu Ile Glu Lys His Phe Pro Ala Pro 
            660                 665                 670         


Asp Arg Lys Lys Leu Tyr Ser Leu Leu Gly Ile Asp Leu Thr Ala Pro 
        675                 680                 685             


Ser Asn Asn Ser Ser Pro Arg Asp Ser Pro Cys Lys Glu Asn Lys Ile 
    690                 695                 700                 


Lys Lys Arg Lys Gly Glu Glu Ile Thr Arg Glu Ala Lys Lys Ala Arg 
705                 710                 715                 720 


Lys Val Gly Gly Leu Thr Gly Ser Ser Ser Asp Asp Ser Gly Ser Glu 
                725                 730                 735     


Ser Asp Ala Ser Asp Asn Glu Glu Ser Asp Tyr Glu Ser Ser Lys Asn 
            740                 745                 750         


Met Ser Ser Gly Asp Asp Asp Asp Phe Asn Pro Phe Leu Asp Glu Ser 
        755                 760                 765             


Asn Glu Asp Asp Glu Asn Asp Pro Trp Leu Ile Arg Lys Asp His Lys 
    770                 775                 780                 


Lys Asn Lys Glu Lys Lys Lys Lys Lys Ser Ile Asp Pro Asp Ser Ile 
785                 790                 795                 800 


Gln Ser Ala Leu Leu Ala Ser Gly Leu Gly Ser Lys Arg Pro Ser Phe 
                805                 810                 815     


Ser Ser Thr Pro Val Ile Ser Pro Ala Pro Asn Ser Thr Pro Ala Asn 
            820                 825                 830         


Ser Asn Thr Asn Ser Asn Ser Ser Leu Ile Thr Ser Gln Asp Ala Val 
        835                 840                 845             


Glu Arg Ala Gln Gln Met Lys Lys Asp Leu Leu Asp Lys Leu Glu Lys 
    850                 855                 860                 


Leu Ala Glu Asp Leu Pro Pro Asn Thr Leu Asp Glu Leu Ile Asp Glu 
865                 870                 875                 880 


Leu Gly Gly Pro Glu Asn Val Ala Glu Met Thr Gly Arg Lys Gly Arg 
                885                 890                 895     


Val Val Ser Asn Asp Asp Gly Ser Ile Ser Tyr Glu Ser Arg Ser Glu 
            900                 905                 910         


Leu Asp Val Pro Val Glu Ile Leu Asn Ile Thr Glu Lys Gln Arg Phe 
        915                 920                 925             


Met Asp Gly Asp Lys Asn Ile Ala Ile Ile Ser Glu Ala Ala Ser Ser 
    930                 935                 940                 


Gly Ile Ser Leu Gln Ala Asp Arg Arg Ala Lys Asn Gln Arg Arg Arg 
945                 950                 955                 960 


Val His Met Thr Leu Glu Leu Pro Trp Ser Ala Asp Arg Ala Ile Gln 
                965                 970                 975     


Gln Phe Gly Arg Thr His Arg Ser Asn Gln Val Thr Ala Pro Glu Tyr 
            980                 985                 990         


Val Phe Leu Ile Ser Glu Leu Ala  Gly Glu Gln Arg Phe  Ala Ser Ile 
        995                 1000                 1005             


Val Ala  Lys Arg Leu Glu Ser  Leu Gly Ala Leu Thr  His Gly Asp 
    1010                 1015                 1020             


Arg Arg  Ala Thr Glu Ser Arg  Asp Leu Ser Arg Phe  Asn Phe Asp 
    1025                 1030                 1035             


Asn Lys  Tyr Gly Arg Asn Ala  Leu Glu Ile Val Met  Lys Ser Ile 
    1040                 1045                 1050             


Val Asn  Leu Asp Ser Pro Met  Val Ser Pro Pro Pro  Asp Tyr Pro 
    1055                 1060                 1065             


Gly Glu  Phe Phe Lys Asp Val  Arg Gln Gly Leu Ile  Gly Val Gly 
    1070                 1075                 1080             


Leu Ile  Asn Val Glu Asp Arg  Ser Gly Ile Leu Thr  Leu Asp Lys 
    1085                 1090                 1095             


Asp Tyr  Asn Asn Ile Gly Lys  Phe Leu Asn Arg Ile  Leu Gly Met 
    1100                 1105                 1110             


Glu Val  His Gln Gln Asn Ala  Leu Phe Gln Tyr Phe  Ala Asp Thr 
    1115                 1120                 1125             


Leu Thr  Ala Val Val Gln Asn  Ala Lys Lys Asn Gly  Arg Tyr Asp 
    1130                 1135                 1140             


Met Gly  Ile Leu Asp Leu Gly  Ser Gly Asp Glu Lys  Val Arg Lys 
    1145                 1150                 1155             


Ser Asp  Val Lys Lys Phe Leu  Thr Pro Gly Tyr Ser  Thr Ser Gly 
    1160                 1165                 1170             


His Val  Glu Leu Tyr Thr Ile  Ser Val Glu Arg Gly  Met Ser Trp 
    1175                 1180                 1185             


Glu Glu  Ala Thr Lys Ile Trp  Ala Glu Leu Thr Gly  Pro Asp Asp 
    1190                 1195                 1200             


Gly Phe  Tyr Leu Ser Leu Gln  Ile Arg Asn Asn Lys  Lys Thr Ala 
    1205                 1210                 1215             


Ile Leu  Val Lys Glu Val Asn  Pro Lys Lys Lys Leu  Phe Leu Val 
    1220                 1225                 1230             


Tyr Arg  Pro Asn Thr Gly Lys  Gln Leu Lys Leu Glu  Ile Tyr Ala 
    1235                 1240                 1245             


Asp Leu  Lys Lys Lys Tyr Lys  Lys Val Val Ser Asp  Asp Ala Leu 
    1250                 1255                 1260             


Met His  Trp Leu Asp Gln Tyr  Asn Ser Ser Ala Asp  Thr Cys Thr 
    1265                 1270                 1275             


His Ala  Tyr Trp Arg Gly Asn  Cys Lys Lys Ala Ser  Leu Gly Leu 
    1280                 1285                 1290             


Val Cys  Glu Ile Gly Leu Arg  Cys Arg Thr Tyr Tyr  Val Leu Cys 
    1295                 1300                 1305             


Gly Ser  Val Leu Ser Val Trp  Thr Lys Val Glu Gly  Val Leu Ala 
    1310                 1315                 1320             


Ser Val  Ser Gly Thr Asn Val  Lys Met Gln Ile Val  Arg Leu Arg 
    1325                 1330                 1335             


Thr Glu  Asp Gly Gln Arg Ile  Val Gly Leu Ile Ile  Pro Ala Asn 
    1340                 1345                 1350             


Cys Val  Ser Pro Leu Val Asn  Leu Leu Ser Thr Ser  Asp Gln Ser 
    1355                 1360                 1365             


Gln Gln  Leu Ala Val Gln Gln  Lys Gln Leu Trp Gln  Gln His His 
    1370                 1375                 1380             


Pro Gln  Ser Ile Thr Asn Leu  Ser Asn Ala 
    1385                 1390             


<210>  101
<211>  473
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q81ZJ4
<309>  2016-09-07
<313>  (1)..(473)

<400>  101

Met Arg Lys Leu Leu Thr Asn Leu Pro Ala Ala Ala Val Leu Ser Ala 
1               5                   10                  15      


Gln Val Tyr Ser Ala Val Leu Gln Gly Leu Trp Glu Glu Asn Val Cys 
            20                  25                  30          


Gly Thr Pro Gly Arg Thr Arg Val Cys Thr Ala Leu Leu Tyr Gly Gln 
        35                  40                  45              


Val Cys Pro Phe Gln Asp Ser Thr Asp Gly Leu Arg Thr Ile Thr Ser 
    50                  55                  60                  


Ile Leu Phe Asn Trp Pro Pro Glu Asn Thr Ser Val Tyr Tyr Gln Pro 
65                  70                  75                  80  


Pro Gln Arg Ser Ser Phe Arg Ile Lys Leu Ala Phe Arg Asn Leu Ser 
                85                  90                  95      


Trp Pro Gly Leu Gly Leu Glu Asp His Gln Glu Ile Val Leu Gly Gln 
            100                 105                 110         


Leu Val Leu Pro Glu Pro Asn Glu Ala Lys Pro Asp Asp Pro Ala Pro 
        115                 120                 125             


Arg Pro Gly Gln His Ala Leu Thr Met Pro Ala Leu Glu Pro Ala Pro 
    130                 135                 140                 


Pro Leu Leu Ala Asp Leu Gly Pro Ala Leu Glu Pro Glu Ser Pro Ala 
145                 150                 155                 160 


Ala Leu Gly Pro Pro Gly Tyr Leu His Ser Ala Pro Gly Pro Ala Pro 
                165                 170                 175     


Ala Pro Gly Glu Gly Pro Pro Pro Gly Thr Val Leu Glu Pro Gln Ser 
            180                 185                 190         


Ala Pro Glu Ser Ser Cys Pro Cys Arg Gly Ser Val Lys Asn Gln Pro 
        195                 200                 205             


Ser Glu Glu Leu Pro Asp Met Thr Thr Phe Pro Pro Arg Leu Leu Ala 
    210                 215                 220                 


Glu Gln Leu Thr Leu Met Asp Ala Glu Leu Phe Lys Lys Val Val Leu 
225                 230                 235                 240 


His Glu Cys Leu Gly Cys Ile Trp Gly Gln Gly His Leu Lys Gly Asn 
                245                 250                 255     


Glu His Met Ala Pro Thr Val Arg Ala Thr Ile Ala His Phe Asn Arg 
            260                 265                 270         


Leu Thr Asn Cys Ile Thr Thr Ser Cys Leu Gly Asp His Ser Met Arg 
        275                 280                 285             


Ala Arg Asp Arg Ala Arg Val Val Glu His Trp Ile Lys Val Ala Arg 
    290                 295                 300                 


Glu Cys Leu Ser Leu Asn Asn Phe Ser Ser Val His Val Ile Val Ser 
305                 310                 315                 320 


Ala Leu Cys Ser Asn Pro Ile Gly Gln Leu His Lys Thr Trp Ala Gly 
                325                 330                 335     


Val Ser Ser Lys Ser Met Lys Glu Leu Lys Glu Leu Cys Lys Lys Asp 
            340                 345                 350         


Thr Ala Val Lys Arg Asp Leu Leu Ile Lys Ala Gly Ser Phe Lys Val 
        355                 360                 365             


Ala Thr Gln Glu Arg Asn Pro Gln Arg Val Gln Met Arg Leu Arg Arg 
    370                 375                 380                 


Gln Lys Lys Gly Val Val Pro Phe Leu Gly Asp Phe Leu Thr Glu Leu 
385                 390                 395                 400 


Gln Arg Leu Asp Ser Ala Ile Pro Asp Asp Leu Asp Gly Asn Thr Asn 
                405                 410                 415     


Lys Arg Ser Lys Glu Val Arg Val Leu Gln Glu Met Gln Leu Leu Gln 
            420                 425                 430         


Val Ala Ala Met Asn Tyr Arg Leu Arg Pro Leu Glu Lys Phe Val Thr 
        435                 440                 445             


Tyr Phe Thr Arg Met Glu Gln Leu Ser Asp Lys Glu Ser Tyr Lys Leu 
    450                 455                 460                 


Ser Cys Gln Leu Glu Pro Glu Asn Pro 
465                 470             


<210>  102
<211>  2968
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O15417
<309>  2005-09-13
<313>  (1)..(2968)

<400>  102

Met Asp Gly Arg Asp Phe Gly Pro Gln Arg Ser Val His Gly Pro Pro 
1               5                   10                  15      


Pro Pro Leu Leu Ser Gly Leu Ala Met Asp Ser His Arg Val Gly Ala 
            20                  25                  30          


Ala Thr Ala Gly Arg Leu Pro Ala Ser Gly Leu Pro Gly Pro Leu Pro 
        35                  40                  45              


Pro Gly Lys Tyr Met Ala Gly Leu Asn Leu His Pro His Pro Gly Glu 
    50                  55                  60                  


Ala Phe Leu Gly Ser Phe Val Ala Ser Gly Met Gly Pro Ser Ala Ser 
65                  70                  75                  80  


Ser His Gly Ser Pro Val Pro Leu Pro Ser Asp Leu Ser Phe Arg Ser 
                85                  90                  95      


Pro Thr Pro Ser Asn Leu Pro Met Val Gln Leu Trp Ala Ala His Ala 
            100                 105                 110         


His Glu Gly Phe Ser His Leu Pro Ser Gly Leu Tyr Pro Ser Tyr Leu 
        115                 120                 125             


His Leu Asn His Leu Glu Pro Pro Ser Ser Gly Ser Pro Leu Leu Ser 
    130                 135                 140                 


Gln Leu Gly Gln Pro Ser Ile Phe Asp Thr Gln Lys Gly Gln Gly Pro 
145                 150                 155                 160 


Gly Gly Asp Gly Phe Tyr Leu Pro Thr Ala Gly Ala Pro Gly Ser Leu 
                165                 170                 175     


His Ser His Ala Pro Ser Ala Arg Thr Pro Gly Gly Gly His Ser Ser 
            180                 185                 190         


Gly Ala Pro Ala Lys Gly Ser Ser Ser Arg Asp Gly Pro Ala Lys Glu 
        195                 200                 205             


Arg Ala Gly Arg Gly Gly Glu Pro Pro Pro Leu Phe Gly Lys Lys Asp 
    210                 215                 220                 


Pro Arg Ala Arg Gly Glu Glu Ala Ser Gly Pro Arg Gly Val Val Asp 
225                 230                 235                 240 


Leu Thr Gln Glu Ala Arg Ala Glu Gly Arg Gln Asp Arg Gly Pro Pro 
                245                 250                 255     


Arg Leu Ala Glu Arg Leu Ser Pro Phe Leu Ala Glu Ser Lys Thr Lys 
            260                 265                 270         


Asn Ala Ala Leu Gln Pro Ser Val Leu Thr Met Cys Asn Gly Gly Ala 
        275                 280                 285             


Gly Asp Val Gly Leu Pro Ala Leu Val Ala Glu Ala Gly Arg Gly Gly 
    290                 295                 300                 


Ala Lys Glu Ala Ala Arg Gln Asp Glu Gly Ala Arg Leu Leu Arg Arg 
305                 310                 315                 320 


Thr Glu Thr Leu Leu Pro Gly Pro Arg Pro Cys Pro Ser Pro Leu Pro 
                325                 330                 335     


Pro Pro Pro Ala Pro Pro Lys Gly Pro Pro Ala Pro Pro Ala Ala Thr 
            340                 345                 350         


Pro Ala Gly Val Tyr Thr Val Phe Arg Glu Gln Gly Arg Glu His Arg 
        355                 360                 365             


Val Val Ala Pro Thr Phe Val Pro Ser Val Glu Ala Phe Asp Glu Arg 
    370                 375                 380                 


Pro Gly Pro Ile Gln Ile Ala Ser Gln Ala Arg Asp Ala Arg Ala Arg 
385                 390                 395                 400 


Glu Arg Glu Ala Gly Arg Pro Gly Val Leu Gln Ala Pro Pro Gly Ser 
                405                 410                 415     


Pro Arg Pro Leu Asp Arg Pro Glu Gly Leu Arg Glu Lys Asn Ser Val 
            420                 425                 430         


Ile Arg Ser Leu Lys Arg Pro Pro Pro Ala Asp Ala Pro Thr Val Arg 
        435                 440                 445             


Ala Thr Arg Ala Ser Pro Asp Pro Arg Ala Tyr Val Pro Ala Lys Glu 
    450                 455                 460                 


Leu Leu Lys Pro Glu Ala Asp Pro Arg Pro Cys Glu Arg Ala Pro Arg 
465                 470                 475                 480 


Gly Pro Ala Gly Pro Ala Ala Gln Gln Ala Ala Lys Leu Phe Gly Leu 
                485                 490                 495     


Glu Pro Gly Arg Pro Pro Pro Thr Gly Pro Glu His Lys Trp Lys Pro 
            500                 505                 510         


Phe Glu Leu Gly Asn Phe Ala Ala Thr Gln Met Ala Val Leu Ala Ala 
        515                 520                 525             


Gln His His His Ser Arg Ala Glu Glu Glu Ala Ala Val Val Ala Ala 
    530                 535                 540                 


Ser Ser Ser Lys Lys Ala Tyr Leu Asp Pro Gly Ala Val Leu Pro Arg 
545                 550                 555                 560 


Ser Ala Ala Thr Cys Gly Arg Pro Val Ala Asp Met His Ser Ala Ala 
                565                 570                 575     


His Gly Ser Gly Glu Ala Ser Ala Met Gln Ser Leu Ile Lys Tyr Ser 
            580                 585                 590         


Gly Ser Phe Ala Arg Asp Ala Val Ala Val Arg Pro Gly Gly Cys Gly 
        595                 600                 605             


Lys Lys Ser Pro Phe Gly Gly Leu Gly Thr Met Lys Pro Glu Pro Ala 
    610                 615                 620                 


Pro Thr Ser Ala Gly Ala Ser Arg Ala Gln Ala Arg Leu Pro His Ser 
625                 630                 635                 640 


Gly Gly Pro Ala Ala Gly Gly Gly Arg Gln Leu Lys Arg Asp Pro Glu 
                645                 650                 655     


Arg Pro Glu Ser Ala Lys Ala Phe Gly Arg Glu Gly Ser Gly Ala Gln 
            660                 665                 670         


Gly Glu Ala Glu Val Arg His Pro Pro Val Gly Ile Ala Val Ala Val 
        675                 680                 685             


Ala Arg Gln Lys Asp Ser Gly Gly Ser Gly Arg Leu Gly Pro Gly Leu 
    690                 695                 700                 


Val Asp Gln Glu Arg Ser Leu Ser Leu Ser Asn Val Lys Gly His Gly 
705                 710                 715                 720 


Arg Ala Asp Glu Asp Cys Val Asp Asp Arg Ala Arg His Arg Glu Glu 
                725                 730                 735     


Arg Leu Leu Gly Ala Arg Leu Asp Arg Asp Gln Glu Lys Leu Leu Arg 
            740                 745                 750         


Glu Ser Lys Glu Leu Ala Asp Leu Ala Arg Leu His Pro Thr Ser Cys 
        755                 760                 765             


Ala Pro Asn Gly Leu Asn Pro Asn Leu Met Val Thr Gly Gly Pro Ala 
    770                 775                 780                 


Leu Ala Gly Ser Gly Arg Trp Ser Ala Asp Pro Ala Ala His Leu Ala 
785                 790                 795                 800 


Thr His Pro Trp Leu Pro Arg Ser Gly Asn Ala Ser Met Trp Leu Ala 
                805                 810                 815     


Gly His Pro Tyr Gly Leu Gly Pro Pro Ser Leu His Gln Gly Met Ala 
            820                 825                 830         


Pro Ala Phe Pro Pro Gly Leu Gly Gly Ser Leu Pro Ser Ala Tyr Gln 
        835                 840                 845             


Phe Val Arg Asp Pro Gln Ser Gly Gln Leu Val Val Ile Pro Ser Asp 
    850                 855                 860                 


His Leu Pro His Phe Ala Glu Leu Met Glu Arg Ala Thr Val Pro Pro 
865                 870                 875                 880 


Leu Trp Pro Ala Leu Tyr Pro Pro Gly Arg Ser Pro Leu His His Ala 
                885                 890                 895     


Gln Gln Leu Gln Leu Phe Ser Gln Gln His Phe Leu Arg Gln Gln Glu 
            900                 905                 910         


Phe Leu Tyr Leu Gln Gln Gln Ala Ala Gln Ala Leu Glu Leu Gln Arg 
        915                 920                 925             


Ser Ala Gln Leu Val Gln Glu Arg Leu Lys Ala Gln Glu His Arg Ala 
    930                 935                 940                 


Glu Met Glu Glu Lys Gly Ser Lys Arg Gly Leu Glu Ala Ala Gly Lys 
945                 950                 955                 960 


Ala Gly Leu Ala Thr Ala Gly Pro Gly Leu Leu Pro Arg Lys Pro Pro 
                965                 970                 975     


Gly Leu Ala Ala Gly Pro Ala Gly Thr Tyr Gly Lys Ala Val Ser Pro 
            980                 985                 990         


Pro Pro Ser Pro Arg Ala Ser Pro  Val Ala Ala Leu Lys  Ala Lys Val 
        995                 1000                 1005             


Ile Gln  Lys Leu Glu Asp Val  Ser Lys Pro Pro Ala  Tyr Ala Tyr 
    1010                 1015                 1020             


Pro Ala  Thr Pro Ser Ser His  Pro Thr Ser Pro Pro  Pro Ala Ser 
    1025                 1030                 1035             


Pro Pro  Pro Thr Pro Gly Ile  Thr Arg Lys Glu Glu  Ala Pro Glu 
    1040                 1045                 1050             


Asn Val  Val Glu Lys Lys Asp  Leu Glu Leu Glu Lys  Glu Ala Pro 
    1055                 1060                 1065             


Ser Pro  Phe Gln Ala Leu Phe  Ser Asp Ile Pro Pro  Arg Tyr Pro 
    1070                 1075                 1080             


Phe Gln  Ala Leu Pro Pro His  Tyr Gly Arg Pro Tyr  Pro Phe Leu 
    1085                 1090                 1095             


Leu Gln  Pro Thr Ala Ala Ala  Asp Ala Asp Gly Leu  Ala Pro Asp 
    1100                 1105                 1110             


Val Pro  Leu Pro Ala Asp Gly  Pro Glu Arg Leu Ala  Leu Ser Pro 
    1115                 1120                 1125             


Glu Asp  Lys Pro Ile Arg Leu  Ser Pro Ser Lys Ile  Thr Glu Pro 
    1130                 1135                 1140             


Leu Arg  Glu Gly Pro Glu Glu  Glu Pro Leu Ala Glu  Arg Glu Val 
    1145                 1150                 1155             


Lys Ala  Glu Val Glu Asp Met  Asp Glu Gly Pro Thr  Glu Leu Pro 
    1160                 1165                 1170             


Pro Leu  Glu Ser Pro Leu Pro  Leu Pro Ala Ala Glu  Ala Met Ala 
    1175                 1180                 1185             


Thr Pro  Ser Pro Ala Gly Gly  Cys Gly Gly Gly Leu  Leu Glu Ala 
    1190                 1195                 1200             


Gln Ala  Leu Ser Ala Thr Gly  Gln Ser Cys Ala Glu  Pro Ser Glu 
    1205                 1210                 1215             


Cys Pro  Asp Phe Val Glu Gly  Pro Glu Pro Arg Val  Asp Ser Pro 
    1220                 1225                 1230             


Gly Arg  Thr Glu Pro Cys Thr  Ala Ala Leu Asp Leu  Gly Val Gln 
    1235                 1240                 1245             


Leu Thr  Pro Glu Thr Leu Val  Glu Ala Lys Glu Glu  Pro Val Glu 
    1250                 1255                 1260             


Val Pro  Val Ala Val Pro Val  Val Glu Ala Val Pro  Glu Glu Gly 
    1265                 1270                 1275             


Leu Ala  Gln Val Ala Pro Ser  Glu Ser Gln Pro Thr  Leu Glu Met 
    1280                 1285                 1290             


Ser Asp  Cys Asp Val Pro Ala  Gly Glu Gly Gln Cys  Pro Ser Leu 
    1295                 1300                 1305             


Glu Pro  Gln Glu Ala Val Pro  Val Leu Gly Ser Thr  Cys Phe Leu 
    1310                 1315                 1320             


Glu Glu  Ala Ser Ser Asp Gln  Phe Leu Pro Ser Leu  Glu Asp Pro 
    1325                 1330                 1335             


Leu Ala  Gly Met Asn Ala Leu  Ala Ala Ala Ala Glu  Leu Pro Gln 
    1340                 1345                 1350             


Ala Arg  Pro Leu Pro Ser Pro  Gly Ala Ala Gly Ala  Gln Ala Leu 
    1355                 1360                 1365             


Glu Lys  Leu Glu Ala Ala Glu  Ser Leu Val Leu Glu  Gln Ser Phe 
    1370                 1375                 1380             


Leu His  Gly Ile Thr Leu Leu  Ser Glu Ile Ala Glu  Leu Glu Leu 
    1385                 1390                 1395             


Glu Arg  Arg Ser Gln Glu Met  Gly Gly Ala Glu Arg  Ala Leu Val 
    1400                 1405                 1410             


Ala Arg  Pro Ser Leu Glu Ser  Leu Leu Ala Ala Gly  Ser His Met 
    1415                 1420                 1425             


Leu Arg  Glu Val Leu Asp Gly  Pro Val Val Asp Pro  Leu Lys Asn 
    1430                 1435                 1440             


Leu Arg  Leu Pro Arg Glu Leu  Lys Pro Asn Lys Lys  Tyr Ser Trp 
    1445                 1450                 1455             


Met Arg  Lys Lys Glu Glu Arg  Met Tyr Ala Met Lys  Ser Ser Leu 
    1460                 1465                 1470             


Glu Asp  Met Asp Ala Leu Glu  Leu Asp Phe Arg Met  Arg Leu Ala 
    1475                 1480                 1485             


Glu Val  Gln Arg Gln Tyr Lys  Glu Lys Gln Arg Glu  Leu Val Lys 
    1490                 1495                 1500             


Leu Gln  Arg Arg Arg Asp Ser  Glu Asp Arg Arg Glu  Glu Pro His 
    1505                 1510                 1515             


Arg Ser  Leu Ala Arg Arg Gly  Pro Gly Arg Pro Arg  Lys Arg Thr 
    1520                 1525                 1530             


His Ala  Pro Ser Ala Leu Ser  Pro Pro Arg Lys Arg  Gly Lys Ser 
    1535                 1540                 1545             


Gly His  Ser Ser Gly Lys Leu  Ser Ser Lys Ser Leu  Leu Thr Ser 
    1550                 1555                 1560             


Asp Asp  Tyr Glu Leu Gly Ala  Gly Ile Arg Lys Arg  His Lys Gly 
    1565                 1570                 1575             


Ser Glu  Glu Glu His Asp Ala  Leu Ile Gly Met Gly  Lys Ala Arg 
    1580                 1585                 1590             


Gly Arg  Asn Gln Thr Trp Asp  Glu His Glu Ala Ser  Ser Asp Phe 
    1595                 1600                 1605             


Ile Ser  Gln Leu Lys Ile Lys  Lys Lys Lys Met Ala  Ser Asp Gln 
    1610                 1615                 1620             


Glu Gln  Leu Ala Ser Lys Leu  Asp Lys Ala Leu Ser  Leu Thr Lys 
    1625                 1630                 1635             


Gln Asp  Lys Leu Lys Ser Pro  Phe Lys Phe Ser Asp  Ser Ala Gly 
    1640                 1645                 1650             


Gly Lys  Ser Lys Thr Ser Gly  Gly Cys Gly Arg Tyr  Leu Thr Pro 
    1655                 1660                 1665             


Tyr Asp  Ser Leu Leu Gly Lys  Asn Arg Lys Ala Leu  Ala Lys Gly 
    1670                 1675                 1680             


Leu Gly  Leu Ser Leu Lys Ser  Ser Arg Glu Gly Lys  His Lys Arg 
    1685                 1690                 1695             


Ala Ala  Lys Thr Arg Lys Met  Glu Val Gly Phe Lys  Ala Arg Gly 
    1700                 1705                 1710             


Gln Pro  Lys Ser Ala His Ser  Pro Phe Ala Ser Glu  Val Ser Ser 
    1715                 1720                 1725             


Tyr Ser  Tyr Asn Thr Asp Ser  Glu Glu Asp Glu Glu  Phe Leu Lys 
    1730                 1735                 1740             


Asp Glu  Trp Pro Ala Gln Gly  Pro Ser Ser Ser Lys  Leu Thr Pro 
    1745                 1750                 1755             


Ser Leu  Leu Cys Ser Met Val  Ala Lys Asn Ser Lys  Ala Ala Gly 
    1760                 1765                 1770             


Gly Pro  Lys Leu Thr Lys Arg  Gly Leu Ala Ala Pro  Arg Thr Leu 
    1775                 1780                 1785             


Lys Pro  Lys Pro Ala Thr Ser  Arg Lys Gln Pro Phe  Cys Leu Leu 
    1790                 1795                 1800             


Leu Arg  Glu Ala Glu Ala Arg  Ser Ser Phe Ser Asp  Ser Ser Glu 
    1805                 1810                 1815             


Glu Ser  Phe Asp Gln Asp Glu  Ser Ser Glu Glu Glu  Asp Glu Glu 
    1820                 1825                 1830             


Glu Glu  Leu Glu Glu Glu Asp  Glu Ala Ser Gly Gly  Gly Tyr Arg 
    1835                 1840                 1845             


Leu Gly  Ala Arg Glu Arg Ala  Leu Ser Pro Gly Leu  Glu Glu Ser 
    1850                 1855                 1860             


Gly Leu  Gly Leu Leu Ala Arg  Phe Ala Ala Ser Ala  Leu Pro Ser 
    1865                 1870                 1875             


Pro Thr  Val Gly Pro Ser Leu  Ser Val Val Gln Leu  Glu Ala Lys 
    1880                 1885                 1890             


Gln Lys  Ala Arg Lys Lys Glu  Glu Arg Gln Ser Leu  Leu Gly Thr 
    1895                 1900                 1905             


Glu Phe  Glu Tyr Thr Asp Ser  Glu Ser Glu Val Lys  Val Arg Lys 
    1910                 1915                 1920             


Arg Ser  Pro Ala Gly Leu Leu  Arg Pro Lys Lys Gly  Leu Gly Glu 
    1925                 1930                 1935             


Pro Gly  Pro Ser Leu Ala Ala  Pro Thr Pro Gly Ala  Arg Gly Pro 
    1940                 1945                 1950             


Asp Pro  Ser Ser Pro Asp Lys  Ala Lys Leu Ala Val  Glu Lys Gly 
    1955                 1960                 1965             


Arg Lys  Ala Arg Lys Leu Arg  Gly Pro Lys Glu Pro  Gly Phe Glu 
    1970                 1975                 1980             


Ala Gly  Pro Glu Ala Ser Asp  Asp Asp Leu Trp Thr  Arg Arg Arg 
    1985                 1990                 1995             


Ser Glu  Arg Ile Phe Leu His  Asp Ala Ser Ala Ala  Ala Pro Ala 
    2000                 2005                 2010             


Pro Val  Ser Thr Ala Pro Ala  Thr Lys Thr Ser Arg  Cys Ala Lys 
    2015                 2020                 2025             


Gly Gly  Pro Leu Ser Pro Arg  Lys Asp Ala Gly Arg  Ala Lys Asp 
    2030                 2035                 2040             


Arg Lys  Asp Pro Arg Lys Lys  Lys Lys Gly Lys Glu  Ala Gly Pro 
    2045                 2050                 2055             


Gly Ala  Gly Leu Pro Pro Pro  Arg Ala Pro Ala Leu  Pro Ser Glu 
    2060                 2065                 2070             


Ala Arg  Ala Pro His Ala Ser  Ser Leu Thr Ala Ala  Lys Arg Ser 
    2075                 2080                 2085             


Lys Ala  Lys Ala Lys Gly Lys  Glu Val Lys Lys Glu  Asn Arg Gly 
    2090                 2095                 2100             


Lys Gly  Gly Ala Val Ser Lys  Leu Met Glu Ser Met  Ala Ala Glu 
    2105                 2110                 2115             


Glu Asp  Phe Glu Pro Asn Gln  Asp Ser Ser Phe Ser  Glu Asp Glu 
    2120                 2125                 2130             


His Leu  Pro Arg Gly Gly Ala  Val Glu Arg Pro Leu  Thr Pro Ala 
    2135                 2140                 2145             


Pro Arg  Ser Cys Ile Ile Asp  Lys Asp Glu Leu Lys  Asp Gly Leu 
    2150                 2155                 2160             


Arg Val  Leu Ile Pro Met Asp  Asp Lys Leu Leu Tyr  Ala Gly His 
    2165                 2170                 2175             


Val Gln  Thr Val His Ser Pro  Asp Ile Tyr Arg Val  Val Val Glu 
    2180                 2185                 2190             


Gly Glu  Arg Gly Asn Arg Pro  His Ile Tyr Cys Leu  Glu Gln Leu 
    2195                 2200                 2205             


Leu Gln  Glu Ala Ile Ile Asp  Val Arg Pro Ala Ser  Thr Arg Phe 
    2210                 2215                 2220             


Leu Pro  Gln Gly Thr Arg Ile  Ala Ala Tyr Trp Ser  Gln Gln Tyr 
    2225                 2230                 2235             


Arg Cys  Leu Tyr Pro Gly Thr  Val Val Arg Gly Leu  Leu Asp Leu 
    2240                 2245                 2250             


Glu Asp  Asp Gly Asp Leu Ile  Thr Val Glu Phe Asp  Asp Gly Asp 
    2255                 2260                 2265             


Thr Gly  Arg Ile Pro Leu Ser  His Ile Arg Leu Leu  Pro Pro Asp 
    2270                 2275                 2280             


Tyr Lys  Ile Gln Cys Ala Glu  Pro Ser Pro Ala Leu  Leu Val Pro 
    2285                 2290                 2295             


Ser Ala  Lys Arg Arg Ser Arg  Lys Thr Ser Lys Asp  Thr Gly Glu 
    2300                 2305                 2310             


Gly Lys  Asp Gly Gly Thr Ala  Gly Ser Glu Glu Pro  Gly Ala Lys 
    2315                 2320                 2325             


Ala Arg  Gly Arg Gly Arg Lys  Pro Ser Ala Lys Ala  Lys Gly Asp 
    2330                 2335                 2340             


Arg Ala  Ala Thr Leu Glu Glu  Gly Asn Pro Thr Asp  Glu Val Pro 
    2345                 2350                 2355             


Ser Thr  Pro Leu Ala Leu Glu  Pro Ser Ser Thr Pro  Gly Ser Lys 
    2360                 2365                 2370             


Lys Ser  Pro Pro Glu Pro Val  Asp Lys Arg Ala Lys  Ala Pro Lys 
    2375                 2380                 2385             


Ala Arg  Pro Ala Pro Pro Gln  Pro Ser Pro Ala Pro  Pro Ala Phe 
    2390                 2395                 2400             


Thr Ser  Cys Pro Ala Pro Glu  Pro Phe Ala Glu Leu  Pro Ala Pro 
    2405                 2410                 2415             


Ala Thr  Ser Leu Ala Pro Ala  Pro Leu Ile Thr Met  Pro Ala Thr 
    2420                 2425                 2430             


Arg Pro  Lys Pro Lys Lys Ala  Arg Ala Ala Glu Glu  Ser Gly Ala 
    2435                 2440                 2445             


Lys Gly  Pro Arg Arg Pro Gly  Glu Glu Ala Glu Leu  Leu Val Lys 
    2450                 2455                 2460             


Leu Asp  His Glu Gly Val Thr  Ser Pro Lys Ser Lys  Lys Ala Lys 
    2465                 2470                 2475             


Glu Ala  Leu Leu Leu Arg Glu  Asp Pro Gly Ala Gly  Gly Trp Gln 
    2480                 2485                 2490             


Glu Pro  Lys Ser Leu Leu Ser  Leu Gly Ser Tyr Pro  Pro Ala Ala 
    2495                 2500                 2505             


Gly Ser  Ser Glu Pro Lys Ala  Pro Trp Pro Lys Ala  Thr Asp Gly 
    2510                 2515                 2520             


Asp Leu  Ala Gln Glu Pro Gly  Pro Gly Leu Thr Phe  Glu Asp Ser 
    2525                 2530                 2535             


Gly Asn  Pro Lys Ser Pro Asp  Lys Ala Gln Ala Glu  Gln Asp Gly 
    2540                 2545                 2550             


Ala Glu  Glu Ser Glu Ser Ser  Ser Ser Ser Ser Ser  Gly Ser Ser 
    2555                 2560                 2565             


Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Gly Ser Glu  Thr Glu Gly 
    2570                 2575                 2580             


Glu Glu  Glu Gly Asp Lys Asn  Gly Asp Gly Gly Cys  Gly Thr Gly 
    2585                 2590                 2595             


Gly Arg  Asn Cys Ser Ala Ala  Ser Ser Arg Ala Ala  Ser Pro Ala 
    2600                 2605                 2610             


Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser 
    2615                 2620                 2625             


Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser 
    2630                 2635                 2640             


Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser 
    2645                 2650                 2655             


Ser Ser  Ser Ser Ser Ser Ser  Ser Ser Ser Ser Ser  Ser Thr Thr 
    2660                 2665                 2670             


Asp Glu  Asp Ser Ser Cys Ser  Ser Asp Asp Glu Ala  Ala Pro Ala 
    2675                 2680                 2685             


Pro Thr  Ala Gly Pro Ser Ala  Gln Ala Ala Leu Pro  Thr Lys Ala 
    2690                 2695                 2700             


Thr Lys  Gln Ala Gly Lys Ala  Arg Pro Ser Ala His  Ser Pro Gly 
    2705                 2710                 2715             


Lys Lys  Thr Pro Ala Pro Gln  Pro Gln Ala Pro Pro  Pro Gln Pro 
    2720                 2725                 2730             


Thr Gln  Pro Leu Gln Pro Lys  Ala Gln Ala Gly Ala  Lys Ser Arg 
    2735                 2740                 2745             


Pro Lys  Lys Arg Glu Gly Val  His Leu Pro Thr Thr  Lys Glu Leu 
    2750                 2755                 2760             


Ala Lys  Arg Gln Arg Leu Pro  Ser Val Glu Asn Arg  Pro Lys Ile 
    2765                 2770                 2775             


Ala Ala  Phe Leu Pro Ala Arg  Gln Leu Trp Lys Trp  Phe Gly Lys 
    2780                 2785                 2790             


Pro Thr  Gln Arg Arg Gly Met  Lys Gly Lys Ala Arg  Lys Leu Phe 
    2795                 2800                 2805             


Tyr Lys  Ala Ile Val Arg Gly  Lys Glu Met Ile Arg  Ile Gly Asp 
    2810                 2815                 2820             


Cys Ala  Val Phe Leu Ser Ala  Gly Arg Pro Asn Leu  Pro Tyr Ile 
    2825                 2830                 2835             


Gly Arg  Ile Gln Ser Met Trp  Glu Ser Trp Gly Asn  Asn Met Val 
    2840                 2845                 2850             


Val Arg  Val Lys Trp Phe Tyr  His Pro Glu Glu Thr  Ser Pro Gly 
    2855                 2860                 2865             


Lys Gln  Phe His Gln Gly Gln  His Trp Asp Gln Lys  Ser Ser Arg 
    2870                 2875                 2880             


Ser Leu  Pro Ala Ala Leu Arg  Val Ser Ser Gln Arg  Lys Asp Phe 
    2885                 2890                 2895             


Met Glu  Arg Ala Leu Tyr Gln  Ser Ser His Val Asp  Glu Asn Asp 
    2900                 2905                 2910             


Val Gln  Thr Val Ser His Lys  Cys Leu Val Val Gly  Leu Glu Gln 
    2915                 2920                 2925             


Tyr Glu  Gln Met Leu Lys Thr  Lys Lys Tyr Gln Asp  Ser Glu Gly 
    2930                 2935                 2940             


Leu Tyr  Tyr Leu Ala Gly Thr  Tyr Glu Pro Thr Thr  Gly Met Ile 
    2945                 2950                 2955             


Phe Ser  Thr Asp Gly Val Pro  Val Leu Cys 
    2960                 2965             


<210>  103
<211>  671
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q7Z4V5
<309>  2016-09-07
<313>  (1)..(671)

<400>  103

Met Pro His Ala Phe Lys Pro Gly Asp Leu Val Phe Ala Lys Met Lys 
1               5                   10                  15      


Gly Tyr Pro His Trp Pro Ala Arg Ile Asp Asp Ile Ala Asp Gly Ala 
            20                  25                  30          


Val Lys Pro Pro Pro Asn Lys Tyr Pro Ile Phe Phe Phe Gly Thr His 
        35                  40                  45              


Glu Thr Ala Phe Leu Gly Pro Lys Asp Leu Phe Pro Tyr Asp Lys Cys 
    50                  55                  60                  


Lys Asp Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly 
65                  70                  75                  80  


Leu Trp Glu Ile Gln Asn Asn Pro His Ala Ser Tyr Ser Ala Pro Pro 
                85                  90                  95      


Pro Val Ser Ser Ser Asp Ser Glu Ala Pro Glu Ala Asn Pro Ala Asp 
            100                 105                 110         


Gly Ser Asp Ala Asp Glu Asp Asp Glu Asp Arg Gly Val Met Ala Val 
        115                 120                 125             


Thr Ala Val Thr Ala Thr Ala Ala Ser Asp Arg Met Glu Ser Asp Ser 
    130                 135                 140                 


Asp Ser Asp Lys Ser Ser Asp Asn Ser Gly Leu Lys Arg Lys Thr Pro 
145                 150                 155                 160 


Ala Leu Lys Met Ser Val Ser Lys Arg Ala Arg Lys Ala Ser Ser Asp 
                165                 170                 175     


Leu Asp Gln Ala Ser Val Ser Pro Ser Glu Glu Glu Asn Ser Glu Ser 
            180                 185                 190         


Ser Ser Glu Ser Glu Lys Thr Ser Asp Gln Asp Phe Thr Pro Glu Lys 
        195                 200                 205             


Lys Ala Ala Val Arg Ala Pro Arg Arg Gly Pro Leu Gly Gly Arg Lys 
    210                 215                 220                 


Lys Lys Lys Ala Pro Ser Ala Ser Asp Ser Asp Ser Lys Ala Asp Ser 
225                 230                 235                 240 


Asp Gly Ala Lys Pro Glu Pro Val Ala Met Ala Arg Ser Ala Ser Ser 
                245                 250                 255     


Ser Ser Ser Ser Ser Ser Ser Ser Asp Ser Asp Val Ser Val Lys Lys 
            260                 265                 270         


Pro Pro Arg Gly Arg Lys Pro Ala Glu Lys Pro Leu Pro Lys Pro Arg 
        275                 280                 285             


Gly Arg Lys Pro Lys Pro Glu Arg Pro Pro Ser Ser Ser Ser Ser Asp 
    290                 295                 300                 


Ser Asp Ser Asp Glu Val Asp Arg Ile Ser Glu Trp Lys Arg Arg Asp 
305                 310                 315                 320 


Glu Ala Arg Arg Arg Glu Leu Glu Ala Arg Arg Arg Arg Glu Gln Glu 
                325                 330                 335     


Glu Glu Leu Arg Arg Leu Arg Glu Gln Glu Lys Glu Glu Lys Glu Arg 
            340                 345                 350         


Arg Arg Glu Arg Ala Asp Arg Gly Glu Ala Glu Arg Gly Ser Gly Gly 
        355                 360                 365             


Ser Ser Gly Asp Glu Leu Arg Glu Asp Asp Glu Pro Val Lys Lys Arg 
    370                 375                 380                 


Gly Arg Lys Gly Arg Gly Arg Gly Pro Pro Ser Ser Ser Asp Ser Glu 
385                 390                 395                 400 


Pro Glu Ala Glu Leu Glu Arg Glu Ala Lys Lys Ser Ala Lys Lys Pro 
                405                 410                 415     


Gln Ser Ser Ser Thr Glu Pro Ala Arg Lys Pro Gly Gln Lys Glu Lys 
            420                 425                 430         


Arg Val Arg Pro Glu Glu Lys Gln Gln Ala Lys Pro Val Lys Val Glu 
        435                 440                 445             


Arg Thr Arg Lys Arg Ser Glu Gly Phe Ser Met Asp Arg Lys Val Glu 
    450                 455                 460                 


Lys Lys Lys Glu Pro Ser Val Glu Glu Lys Leu Gln Lys Leu His Ser 
465                 470                 475                 480 


Glu Ile Lys Phe Ala Leu Lys Val Asp Ser Pro Asp Val Lys Arg Cys 
                485                 490                 495     


Leu Asn Ala Leu Glu Glu Leu Gly Thr Leu Gln Val Thr Ser Gln Ile 
            500                 505                 510         


Leu Gln Lys Asn Thr Asp Val Val Ala Thr Leu Lys Lys Ile Arg Arg 
        515                 520                 525             


Tyr Lys Ala Asn Lys Asp Val Met Glu Lys Ala Ala Glu Val Tyr Thr 
    530                 535                 540                 


Arg Leu Lys Ser Arg Val Leu Gly Pro Lys Ile Glu Ala Val Gln Lys 
545                 550                 555                 560 


Val Asn Lys Ala Gly Met Glu Lys Glu Lys Ala Glu Glu Lys Leu Ala 
                565                 570                 575     


Gly Glu Glu Leu Ala Gly Glu Glu Ala Pro Gln Glu Lys Ala Glu Asp 
            580                 585                 590         


Lys Pro Ser Thr Asp Leu Ser Ala Pro Val Asn Gly Glu Ala Thr Ser 
        595                 600                 605             


Gln Lys Gly Glu Ser Ala Glu Asp Lys Glu His Glu Glu Gly Arg Asp 
    610                 615                 620                 


Ser Glu Glu Gly Pro Arg Cys Gly Ser Ser Glu Asp Leu His Asp Ser 
625                 630                 635                 640 


Val Arg Glu Gly Pro Asp Leu Asp Arg Pro Gly Ser Asp Arg Gln Glu 
                645                 650                 655     


Arg Glu Arg Ala Arg Gly Asp Ser Glu Ala Leu Asp Glu Glu Ser 
            660                 665                 670     


<210>  104
<211>  195
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9UBI1
<309>  2016-09-07
<313>  (1)..(195)

<400>  104

Met Glu Leu Ser Glu Ser Val Gln Lys Gly Phe Gln Met Leu Ala Asp 
1               5                   10                  15      


Pro Arg Ser Phe Asp Ser Asn Ala Phe Thr Leu Leu Leu Arg Ala Ala 
            20                  25                  30          


Phe Gln Ser Leu Leu Asp Ala Gln Ala Asp Glu Ala Val Leu Asp His 
        35                  40                  45              


Pro Asp Leu Lys His Ile Asp Pro Val Val Leu Lys His Cys His Ala 
    50                  55                  60                  


Ala Ala Ala Thr Tyr Ile Leu Glu Ala Gly Lys His Arg Ala Asp Lys 
65                  70                  75                  80  


Ser Thr Leu Ser Thr Tyr Leu Glu Asp Cys Lys Phe Asp Arg Glu Arg 
                85                  90                  95      


Ile Glu Leu Phe Cys Thr Glu Tyr Gln Asn Asn Lys Asn Ser Leu Glu 
            100                 105                 110         


Ile Leu Leu Gly Ser Ile Gly Arg Ser Leu Pro His Ile Thr Asp Val 
        115                 120                 125             


Ser Trp Arg Leu Glu Tyr Gln Ile Lys Thr Asn Gln Leu His Arg Met 
    130                 135                 140                 


Tyr Arg Pro Ala Tyr Leu Val Thr Leu Ser Val Gln Asn Thr Asp Ser 
145                 150                 155                 160 


Pro Ser Tyr Pro Glu Ile Ser Phe Ser Cys Ser Met Glu Gln Leu Gln 
                165                 170                 175     


Asp Leu Val Gly Lys Leu Lys Asp Ala Ser Lys Ser Leu Glu Arg Ala 
            180                 185                 190         


Thr Gln Leu 
        195 


<210>  105
<211>  34350
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q8WZ42
<309>  2016-09-07
<313>  (1)..(34350)

<400>  105

Met Thr Thr Gln Ala Pro Thr Phe Thr Gln Pro Leu Gln Ser Val Val 
1               5                   10                  15      


Val Leu Glu Gly Ser Thr Ala Thr Phe Glu Ala His Ile Ser Gly Phe 
            20                  25                  30          


Pro Val Pro Glu Val Ser Trp Phe Arg Asp Gly Gln Val Ile Ser Thr 
        35                  40                  45              


Ser Thr Leu Pro Gly Val Gln Ile Ser Phe Ser Asp Gly Arg Ala Lys 
    50                  55                  60                  


Leu Thr Ile Pro Ala Val Thr Lys Ala Asn Ser Gly Arg Tyr Ser Leu 
65                  70                  75                  80  


Lys Ala Thr Asn Gly Ser Gly Gln Ala Thr Ser Thr Ala Glu Leu Leu 
                85                  90                  95      


Val Lys Ala Glu Thr Ala Pro Pro Asn Phe Val Gln Arg Leu Gln Ser 
            100                 105                 110         


Met Thr Val Arg Gln Gly Ser Gln Val Arg Leu Gln Val Arg Val Thr 
        115                 120                 125             


Gly Ile Pro Thr Pro Val Val Lys Phe Tyr Arg Asp Gly Ala Glu Ile 
    130                 135                 140                 


Gln Ser Ser Leu Asp Phe Gln Ile Ser Gln Glu Gly Asp Leu Tyr Ser 
145                 150                 155                 160 


Leu Leu Ile Ala Glu Ala Tyr Pro Glu Asp Ser Gly Thr Tyr Ser Val 
                165                 170                 175     


Asn Ala Thr Asn Ser Val Gly Arg Ala Thr Ser Thr Ala Glu Leu Leu 
            180                 185                 190         


Val Gln Gly Glu Glu Glu Val Pro Ala Lys Lys Thr Lys Thr Ile Val 
        195                 200                 205             


Ser Thr Ala Gln Ile Ser Glu Ser Arg Gln Thr Arg Ile Glu Lys Lys 
    210                 215                 220                 


Ile Glu Ala His Phe Asp Ala Arg Ser Ile Ala Thr Val Glu Met Val 
225                 230                 235                 240 


Ile Asp Gly Ala Ala Gly Gln Gln Leu Pro His Lys Thr Pro Pro Arg 
                245                 250                 255     


Ile Pro Pro Lys Pro Lys Ser Arg Ser Pro Thr Pro Pro Ser Ile Ala 
            260                 265                 270         


Ala Lys Ala Gln Leu Ala Arg Gln Gln Ser Pro Ser Pro Ile Arg His 
        275                 280                 285             


Ser Pro Ser Pro Val Arg His Val Arg Ala Pro Thr Pro Ser Pro Val 
    290                 295                 300                 


Arg Ser Val Ser Pro Ala Ala Arg Ile Ser Thr Ser Pro Ile Arg Ser 
305                 310                 315                 320 


Val Arg Ser Pro Leu Leu Met Arg Lys Thr Gln Ala Ser Thr Val Ala 
                325                 330                 335     


Thr Gly Pro Glu Val Pro Pro Pro Trp Lys Gln Glu Gly Tyr Val Ala 
            340                 345                 350         


Ser Ser Ser Glu Ala Glu Met Arg Glu Thr Thr Leu Thr Thr Ser Thr 
        355                 360                 365             


Gln Ile Arg Thr Glu Glu Arg Trp Glu Gly Arg Tyr Gly Val Gln Glu 
    370                 375                 380                 


Gln Val Thr Ile Ser Gly Ala Ala Gly Ala Ala Ala Ser Val Ser Ala 
385                 390                 395                 400 


Ser Ala Ser Tyr Ala Ala Glu Ala Val Ala Thr Gly Ala Lys Glu Val 
                405                 410                 415     


Lys Gln Asp Ala Asp Lys Ser Ala Ala Val Ala Thr Val Val Ala Ala 
            420                 425                 430         


Val Asp Met Ala Arg Val Arg Glu Pro Val Ile Ser Ala Val Glu Gln 
        435                 440                 445             


Thr Ala Gln Arg Thr Thr Thr Thr Ala Val His Ile Gln Pro Ala Gln 
    450                 455                 460                 


Glu Gln Val Arg Lys Glu Ala Glu Lys Thr Ala Val Thr Lys Val Val 
465                 470                 475                 480 


Val Ala Ala Asp Lys Ala Lys Glu Gln Glu Leu Lys Ser Arg Thr Lys 
                485                 490                 495     


Glu Val Ile Thr Thr Lys Gln Glu Gln Met His Val Thr His Glu Gln 
            500                 505                 510         


Ile Arg Lys Glu Thr Glu Lys Thr Phe Val Pro Lys Val Val Ile Ser 
        515                 520                 525             


Ala Ala Lys Ala Lys Glu Gln Glu Thr Arg Ile Ser Glu Glu Ile Thr 
    530                 535                 540                 


Lys Lys Gln Lys Gln Val Thr Gln Glu Ala Ile Arg Gln Glu Thr Glu 
545                 550                 555                 560 


Ile Thr Ala Ala Ser Met Val Val Val Ala Thr Ala Lys Ser Thr Lys 
                565                 570                 575     


Leu Glu Thr Val Pro Gly Ala Gln Glu Glu Thr Thr Thr Gln Gln Asp 
            580                 585                 590         


Gln Met His Leu Ser Tyr Glu Lys Ile Met Lys Glu Thr Arg Lys Thr 
        595                 600                 605             


Val Val Pro Lys Val Ile Val Ala Thr Pro Lys Val Lys Glu Gln Asp 
    610                 615                 620                 


Leu Val Ser Arg Gly Arg Glu Gly Ile Thr Thr Lys Arg Glu Gln Val 
625                 630                 635                 640 


Gln Ile Thr Gln Glu Lys Met Arg Lys Glu Ala Glu Lys Thr Ala Leu 
                645                 650                 655     


Ser Thr Ile Ala Val Ala Thr Ala Lys Ala Lys Glu Gln Glu Thr Ile 
            660                 665                 670         


Leu Arg Thr Arg Glu Thr Met Ala Thr Arg Gln Glu Gln Ile Gln Val 
        675                 680                 685             


Thr His Gly Lys Val Asp Val Gly Lys Lys Ala Glu Ala Val Ala Thr 
    690                 695                 700                 


Val Val Ala Ala Val Asp Gln Ala Arg Val Arg Glu Pro Arg Glu Pro 
705                 710                 715                 720 


Gly His Leu Glu Glu Ser Tyr Ala Gln Gln Thr Thr Leu Glu Tyr Gly 
                725                 730                 735     


Tyr Lys Glu Arg Ile Ser Ala Ala Lys Val Ala Glu Pro Pro Gln Arg 
            740                 745                 750         


Pro Ala Ser Glu Pro His Val Val Pro Lys Ala Val Lys Pro Arg Val 
        755                 760                 765             


Ile Gln Ala Pro Ser Glu Thr His Ile Lys Thr Thr Asp Gln Lys Gly 
    770                 775                 780                 


Met His Ile Ser Ser Gln Ile Lys Lys Thr Thr Asp Leu Thr Thr Glu 
785                 790                 795                 800 


Arg Leu Val His Val Asp Lys Arg Pro Arg Thr Ala Ser Pro His Phe 
                805                 810                 815     


Thr Val Ser Lys Ile Ser Val Pro Lys Thr Glu His Gly Tyr Glu Ala 
            820                 825                 830         


Ser Ile Ala Gly Ser Ala Ile Ala Thr Leu Gln Lys Glu Leu Ser Ala 
        835                 840                 845             


Thr Ser Ser Ala Gln Lys Ile Thr Lys Ser Val Lys Ala Pro Thr Val 
    850                 855                 860                 


Lys Pro Ser Glu Thr Arg Val Arg Ala Glu Pro Thr Pro Leu Pro Gln 
865                 870                 875                 880 


Phe Pro Phe Ala Asp Thr Pro Asp Thr Tyr Lys Ser Glu Ala Gly Val 
                885                 890                 895     


Glu Val Lys Lys Glu Val Gly Val Ser Ile Thr Gly Thr Thr Val Arg 
            900                 905                 910         


Glu Glu Arg Phe Glu Val Leu His Gly Arg Glu Ala Lys Val Thr Glu 
        915                 920                 925             


Thr Ala Arg Val Pro Ala Pro Val Glu Ile Pro Val Thr Pro Pro Thr 
    930                 935                 940                 


Leu Val Ser Gly Leu Lys Asn Val Thr Val Ile Glu Gly Glu Ser Val 
945                 950                 955                 960 


Thr Leu Glu Cys His Ile Ser Gly Tyr Pro Ser Pro Thr Val Thr Trp 
                965                 970                 975     


Tyr Arg Glu Asp Tyr Gln Ile Glu Ser Ser Ile Asp Phe Gln Ile Thr 
            980                 985                 990         


Phe Gln Ser Gly Ile Ala Arg Leu  Met Ile Arg Glu Ala  Phe Ala Glu 
        995                 1000                 1005             


Asp Ser  Gly Arg Phe Thr Cys  Ser Ala Val Asn Glu  Ala Gly Thr 
    1010                 1015                 1020             


Val Ser  Thr Ser Cys Tyr Leu  Ala Val Gln Val Ser  Glu Glu Phe 
    1025                 1030                 1035             


Glu Lys  Glu Thr Thr Ala Val  Thr Glu Lys Phe Thr  Thr Glu Glu 
    1040                 1045                 1050             


Lys Arg  Phe Val Glu Ser Arg  Asp Val Val Met Thr  Asp Thr Ser 
    1055                 1060                 1065             


Leu Thr  Glu Glu Gln Ala Gly  Pro Gly Glu Pro Ala  Ala Pro Tyr 
    1070                 1075                 1080             


Phe Ile  Thr Lys Pro Val Val  Gln Lys Leu Val Glu  Gly Gly Ser 
    1085                 1090                 1095             


Val Val  Phe Gly Cys Gln Val  Gly Gly Asn Pro Lys  Pro His Val 
    1100                 1105                 1110             


Tyr Trp  Lys Lys Ser Gly Val  Pro Leu Thr Thr Gly  Tyr Arg Tyr 
    1115                 1120                 1125             


Lys Val  Ser Tyr Asn Lys Gln  Thr Gly Glu Cys Lys  Leu Val Ile 
    1130                 1135                 1140             


Ser Met  Thr Phe Ala Asp Asp  Ala Gly Glu Tyr Thr  Ile Val Val 
    1145                 1150                 1155             


Arg Asn  Lys His Gly Glu Thr  Ser Ala Ser Ala Ser  Leu Leu Glu 
    1160                 1165                 1170             


Glu Ala  Asp Tyr Glu Leu Leu  Met Lys Ser Gln Gln  Glu Met Leu 
    1175                 1180                 1185             


Tyr Gln  Thr Gln Val Thr Ala  Phe Val Gln Glu Pro  Lys Val Gly 
    1190                 1195                 1200             


Glu Thr  Ala Pro Gly Phe Val  Tyr Ser Glu Tyr Glu  Lys Glu Tyr 
    1205                 1210                 1215             


Glu Lys  Glu Gln Ala Leu Ile  Arg Lys Lys Met Ala  Lys Asp Thr 
    1220                 1225                 1230             


Val Val  Val Arg Thr Tyr Val  Glu Asp Gln Glu Phe  His Ile Ser 
    1235                 1240                 1245             


Ser Phe  Glu Glu Arg Leu Ile  Lys Glu Ile Glu Tyr  Arg Ile Ile 
    1250                 1255                 1260             


Lys Thr  Thr Leu Glu Glu Leu  Leu Glu Glu Asp Gly  Glu Glu Lys 
    1265                 1270                 1275             


Met Ala  Val Asp Ile Ser Glu  Ser Glu Ala Val Glu  Ser Gly Phe 
    1280                 1285                 1290             


Asp Ser  Arg Ile Lys Asn Tyr  Arg Ile Leu Glu Gly  Met Gly Val 
    1295                 1300                 1305             


Thr Phe  His Cys Lys Met Ser  Gly Tyr Pro Leu Pro  Lys Ile Ala 
    1310                 1315                 1320             


Trp Tyr  Lys Asp Gly Lys Arg  Ile Lys His Gly Glu  Arg Tyr Gln 
    1325                 1330                 1335             


Met Asp  Phe Leu Gln Asp Gly  Arg Ala Ser Leu Arg  Ile Pro Val 
    1340                 1345                 1350             


Val Leu  Pro Glu Asp Glu Gly  Ile Tyr Thr Ala Phe  Ala Ser Asn 
    1355                 1360                 1365             


Ile Lys  Gly Asn Ala Ile Cys  Ser Gly Lys Leu Tyr  Val Glu Pro 
    1370                 1375                 1380             


Ala Ala  Pro Leu Gly Ala Pro  Thr Tyr Ile Pro Thr  Leu Glu Pro 
    1385                 1390                 1395             


Val Ser  Arg Ile Arg Ser Leu  Ser Pro Arg Ser Val  Ser Arg Ser 
    1400                 1405                 1410             


Pro Ile  Arg Met Ser Pro Ala  Arg Met Ser Pro Ala  Arg Met Ser 
    1415                 1420                 1425             


Pro Ala  Arg Met Ser Pro Ala  Arg Met Ser Pro Gly  Arg Arg Leu 
    1430                 1435                 1440             


Glu Glu  Thr Asp Glu Ser Gln  Leu Glu Arg Leu Tyr  Lys Pro Val 
    1445                 1450                 1455             


Phe Val  Leu Lys Pro Val Ser  Phe Lys Cys Leu Glu  Gly Gln Thr 
    1460                 1465                 1470             


Ala Arg  Phe Asp Leu Lys Val  Val Gly Arg Pro Met  Pro Glu Thr 
    1475                 1480                 1485             


Phe Trp  Phe His Asp Gly Gln  Gln Ile Val Asn Asp  Tyr Thr His 
    1490                 1495                 1500             


Lys Val  Val Ile Lys Glu Asp  Gly Thr Gln Ser Leu  Ile Ile Val 
    1505                 1510                 1515             


Pro Ala  Thr Pro Ser Asp Ser  Gly Glu Trp Thr Val  Val Ala Gln 
    1520                 1525                 1530             


Asn Arg  Ala Gly Arg Ser Ser  Ile Ser Val Ile Leu  Thr Val Glu 
    1535                 1540                 1545             


Ala Val  Glu His Gln Val Lys  Pro Met Phe Val Glu  Lys Leu Lys 
    1550                 1555                 1560             


Asn Val  Asn Ile Lys Glu Gly  Ser Arg Leu Glu Met  Lys Val Arg 
    1565                 1570                 1575             


Ala Thr  Gly Asn Pro Asn Pro  Asp Ile Val Trp Leu  Lys Asn Ser 
    1580                 1585                 1590             


Asp Ile  Ile Val Pro His Lys  Tyr Pro Lys Ile Arg  Ile Glu Gly 
    1595                 1600                 1605             


Thr Lys  Gly Glu Ala Ala Leu  Lys Ile Asp Ser Thr  Val Ser Gln 
    1610                 1615                 1620             


Asp Ser  Ala Trp Tyr Thr Ala  Thr Ala Ile Asn Lys  Ala Gly Arg 
    1625                 1630                 1635             


Asp Thr  Thr Arg Cys Lys Val  Asn Val Glu Val Glu  Phe Ala Glu 
    1640                 1645                 1650             


Pro Glu  Pro Glu Arg Lys Leu  Ile Ile Pro Arg Gly  Thr Tyr Arg 
    1655                 1660                 1665             


Ala Lys  Glu Ile Ala Ala Pro  Glu Leu Glu Pro Leu  His Leu Arg 
    1670                 1675                 1680             


Tyr Gly  Gln Glu Gln Trp Glu  Glu Gly Asp Leu Tyr  Asp Lys Glu 
    1685                 1690                 1695             


Lys Gln  Gln Lys Pro Phe Phe  Lys Lys Lys Leu Thr  Ser Leu Arg 
    1700                 1705                 1710             


Leu Lys  Arg Phe Gly Pro Ala  His Phe Glu Cys Arg  Leu Thr Pro 
    1715                 1720                 1725             


Ile Gly  Asp Pro Thr Met Val  Val Glu Trp Leu His  Asp Gly Lys 
    1730                 1735                 1740             


Pro Leu  Glu Ala Ala Asn Arg  Leu Arg Met Ile Asn  Glu Phe Gly 
    1745                 1750                 1755             


Tyr Cys  Ser Leu Asp Tyr Gly  Val Ala Tyr Ser Arg  Asp Ser Gly 
    1760                 1765                 1770             


Ile Ile  Thr Cys Arg Ala Thr  Asn Lys Tyr Gly Thr  Asp His Thr 
    1775                 1780                 1785             


Ser Ala  Thr Leu Ile Val Lys  Asp Glu Lys Ser Leu  Val Glu Glu 
    1790                 1795                 1800             


Ser Gln  Leu Pro Glu Gly Arg  Lys Gly Leu Gln Arg  Ile Glu Glu 
    1805                 1810                 1815             


Leu Glu  Arg Met Ala His Glu  Gly Ala Leu Thr Gly  Val Thr Thr 
    1820                 1825                 1830             


Asp Gln  Lys Glu Lys Gln Lys  Pro Asp Ile Val Leu  Tyr Pro Glu 
    1835                 1840                 1845             


Pro Val  Arg Val Leu Glu Gly  Glu Thr Ala Arg Phe  Arg Cys Arg 
    1850                 1855                 1860             


Val Thr  Gly Tyr Pro Gln Pro  Lys Val Asn Trp Tyr  Leu Asn Gly 
    1865                 1870                 1875             


Gln Leu  Ile Arg Lys Ser Lys  Arg Phe Arg Val Arg  Tyr Asp Gly 
    1880                 1885                 1890             


Ile His  Tyr Leu Asp Ile Val  Asp Cys Lys Ser Tyr  Asp Thr Gly 
    1895                 1900                 1905             


Glu Val  Lys Val Thr Ala Glu  Asn Pro Glu Gly Val  Ile Glu His 
    1910                 1915                 1920             


Lys Val  Lys Leu Glu Ile Gln  Gln Arg Glu Asp Phe  Arg Ser Val 
    1925                 1930                 1935             


Leu Arg  Arg Ala Pro Glu Pro  Arg Pro Glu Phe His  Val His Glu 
    1940                 1945                 1950             


Pro Gly  Lys Leu Gln Phe Glu  Val Gln Lys Val Asp  Arg Pro Val 
    1955                 1960                 1965             


Asp Thr  Thr Glu Thr Lys Glu  Val Val Lys Leu Lys  Arg Ala Glu 
    1970                 1975                 1980             


Arg Ile  Thr His Glu Lys Val  Pro Glu Glu Ser Glu  Glu Leu Arg 
    1985                 1990                 1995             


Ser Lys  Phe Lys Arg Arg Thr  Glu Glu Gly Tyr Tyr  Glu Ala Ile 
    2000                 2005                 2010             


Thr Ala  Val Glu Leu Lys Ser  Arg Lys Lys Asp Glu  Ser Tyr Glu 
    2015                 2020                 2025             


Glu Leu  Leu Arg Lys Thr Lys  Asp Glu Leu Leu His  Trp Thr Lys 
    2030                 2035                 2040             


Glu Leu  Thr Glu Glu Glu Lys  Lys Ala Leu Ala Glu  Glu Gly Lys 
    2045                 2050                 2055             


Ile Thr  Ile Pro Thr Phe Lys  Pro Asp Lys Ile Glu  Leu Ser Pro 
    2060                 2065                 2070             


Ser Met  Glu Ala Pro Lys Ile  Phe Glu Arg Ile Gln  Ser Gln Thr 
    2075                 2080                 2085             


Val Gly  Gln Gly Ser Asp Ala  His Phe Arg Val Arg  Val Val Gly 
    2090                 2095                 2100             


Lys Pro  Asp Pro Glu Cys Glu  Trp Tyr Lys Asn Gly  Val Lys Ile 
    2105                 2110                 2115             


Glu Arg  Ser Asp Arg Ile Tyr  Trp Tyr Trp Pro Glu  Asp Asn Val 
    2120                 2125                 2130             


Cys Glu  Leu Val Ile Arg Asp  Val Thr Ala Glu Asp  Ser Ala Ser 
    2135                 2140                 2145             


Ile Met  Val Lys Ala Ile Asn  Ile Ala Gly Glu Thr  Ser Ser His 
    2150                 2155                 2160             


Ala Phe  Leu Leu Val Gln Ala  Lys Gln Leu Ile Thr  Phe Thr Gln 
    2165                 2170                 2175             


Glu Leu  Gln Asp Val Val Ala  Lys Glu Lys Asp Thr  Met Ala Thr 
    2180                 2185                 2190             


Phe Glu  Cys Glu Thr Ser Glu  Pro Phe Val Lys Val  Lys Trp Tyr 
    2195                 2200                 2205             


Lys Asp  Gly Met Glu Val His  Glu Gly Asp Lys Tyr  Arg Met His 
    2210                 2215                 2220             


Ser Asp  Arg Lys Val His Phe  Leu Ser Ile Leu Thr  Ile Asp Thr 
    2225                 2230                 2235             


Ser Asp  Ala Glu Asp Tyr Ser  Cys Val Leu Val Glu  Asp Glu Asn 
    2240                 2245                 2250             


Val Lys  Thr Thr Ala Lys Leu  Ile Val Glu Gly Ala  Val Val Glu 
    2255                 2260                 2265             


Phe Val  Lys Glu Leu Gln Asp  Ile Glu Val Pro Glu  Ser Tyr Ser 
    2270                 2275                 2280             


Gly Glu  Leu Glu Cys Ile Val  Ser Pro Glu Asn Ile  Glu Gly Lys 
    2285                 2290                 2295             


Trp Tyr  His Asn Asp Val Glu  Leu Lys Ser Asn Gly  Lys Tyr Thr 
    2300                 2305                 2310             


Ile Thr  Ser Arg Arg Gly Arg  Gln Asn Leu Thr Val  Lys Asp Val 
    2315                 2320                 2325             


Thr Lys  Glu Asp Gln Gly Glu  Tyr Ser Phe Val Ile  Asp Gly Lys 
    2330                 2335                 2340             


Lys Thr  Thr Cys Lys Leu Lys  Met Lys Pro Arg Pro  Ile Ala Ile 
    2345                 2350                 2355             


Leu Gln  Gly Leu Ser Asp Gln  Lys Val Cys Glu Gly  Asp Ile Val 
    2360                 2365                 2370             


Gln Leu  Glu Val Lys Val Ser  Leu Glu Ser Val Glu  Gly Val Trp 
    2375                 2380                 2385             


Met Lys  Asp Gly Gln Glu Val  Gln Pro Ser Asp Arg  Val His Ile 
    2390                 2395                 2400             


Val Ile  Asp Lys Gln Ser His  Met Leu Leu Ile Glu  Asp Met Thr 
    2405                 2410                 2415             


Lys Glu  Asp Ala Gly Asn Tyr  Ser Phe Thr Ile Pro  Ala Leu Gly 
    2420                 2425                 2430             


Leu Ser  Thr Ser Gly Arg Val  Ser Val Tyr Ser Val  Asp Val Ile 
    2435                 2440                 2445             


Thr Pro  Leu Lys Asp Val Asn  Val Ile Glu Gly Thr  Lys Ala Val 
    2450                 2455                 2460             


Leu Glu  Cys Lys Val Ser Val  Pro Asp Val Thr Ser  Val Lys Trp 
    2465                 2470                 2475             


Tyr Leu  Asn Asp Glu Gln Ile  Lys Pro Asp Asp Arg  Val Gln Ala 
    2480                 2485                 2490             


Ile Val  Lys Gly Thr Lys Gln  Arg Leu Val Ile Asn  Arg Thr His 
    2495                 2500                 2505             


Ala Ser  Asp Glu Gly Pro Tyr  Lys Leu Ile Val Gly  Arg Val Glu 
    2510                 2515                 2520             


Thr Asn  Cys Asn Leu Ser Val  Glu Lys Ile Lys Ile  Ile Arg Gly 
    2525                 2530                 2535             


Leu Arg  Asp Leu Thr Cys Thr  Glu Thr Gln Asn Val  Val Phe Glu 
    2540                 2545                 2550             


Val Glu  Leu Ser His Ser Gly  Ile Asp Val Leu Trp  Asn Phe Lys 
    2555                 2560                 2565             


Asp Lys  Glu Ile Lys Pro Ser  Ser Lys Tyr Lys Ile  Glu Ala His 
    2570                 2575                 2580             


Gly Lys  Ile Tyr Lys Leu Thr  Val Leu Asn Met Met  Lys Asp Asp 
    2585                 2590                 2595             


Glu Gly  Lys Tyr Thr Phe Tyr  Ala Gly Glu Asn Met  Thr Ser Gly 
    2600                 2605                 2610             


Lys Leu  Thr Val Ala Gly Gly  Ala Ile Ser Lys Pro  Leu Thr Asp 
    2615                 2620                 2625             


Gln Thr  Val Ala Glu Ser Gln  Glu Ala Val Phe Glu  Cys Glu Val 
    2630                 2635                 2640             


Ala Asn  Pro Asp Ser Lys Gly  Glu Trp Leu Arg Asp  Gly Lys His 
    2645                 2650                 2655             


Leu Pro  Leu Thr Asn Asn Ile  Arg Ser Glu Ser Asp  Gly His Lys 
    2660                 2665                 2670             


Arg Arg  Leu Ile Ile Ala Ala  Thr Lys Leu Asp Asp  Ile Gly Glu 
    2675                 2680                 2685             


Tyr Thr  Tyr Lys Val Ala Thr  Ser Lys Thr Ser Ala  Lys Leu Lys 
    2690                 2695                 2700             


Val Glu  Ala Val Lys Ile Lys  Lys Thr Leu Lys Asn  Leu Thr Val 
    2705                 2710                 2715             


Thr Glu  Thr Gln Asp Ala Val  Phe Thr Val Glu Leu  Thr His Pro 
    2720                 2725                 2730             


Asn Val  Lys Gly Val Gln Trp  Ile Lys Asn Gly Val  Val Leu Glu 
    2735                 2740                 2745             


Ser Asn  Glu Lys Tyr Ala Ile  Ser Val Lys Gly Thr  Ile Tyr Ser 
    2750                 2755                 2760             


Leu Arg  Ile Lys Asn Cys Ala  Ile Val Asp Glu Ser  Val Tyr Gly 
    2765                 2770                 2775             


Phe Arg  Leu Gly Arg Leu Gly  Ala Ser Ala Arg Leu  His Val Glu 
    2780                 2785                 2790             


Thr Val  Lys Ile Ile Lys Lys  Pro Lys Asp Val Thr  Ala Leu Glu 
    2795                 2800                 2805             


Asn Ala  Thr Val Ala Phe Glu  Val Ser Val Ser His  Asp Thr Val 
    2810                 2815                 2820             


Pro Val  Lys Trp Phe His Lys  Ser Val Glu Ile Lys  Pro Ser Asp 
    2825                 2830                 2835             


Lys His  Arg Leu Val Ser Glu  Arg Lys Val His Lys  Leu Met Leu 
    2840                 2845                 2850             


Gln Asn  Ile Ser Pro Ser Asp  Ala Gly Glu Tyr Thr  Ala Val Val 
    2855                 2860                 2865             


Gly Gln  Leu Glu Cys Lys Ala  Lys Leu Phe Val Glu  Thr Leu His 
    2870                 2875                 2880             


Ile Thr  Lys Thr Met Lys Asn  Ile Glu Val Pro Glu  Thr Lys Thr 
    2885                 2890                 2895             


Ala Ser  Phe Glu Cys Glu Val  Ser His Phe Asn Val  Pro Ser Met 
    2900                 2905                 2910             


Trp Leu  Lys Asn Gly Val Glu  Ile Glu Met Ser Glu  Lys Phe Lys 
    2915                 2920                 2925             


Ile Val  Val Gln Gly Lys Leu  His Gln Leu Ile Ile  Met Asn Thr 
    2930                 2935                 2940             


Ser Thr  Glu Asp Ser Ala Glu  Tyr Thr Phe Val Cys  Gly Asn Asp 
    2945                 2950                 2955             


Gln Val  Ser Ala Thr Leu Thr  Val Thr Pro Ile Met  Ile Thr Ser 
    2960                 2965                 2970             


Met Leu  Lys Asp Ile Asn Ala  Glu Glu Lys Asp Thr  Ile Thr Phe 
    2975                 2980                 2985             


Glu Val  Thr Val Asn Tyr Glu  Gly Ile Ser Tyr Lys  Trp Leu Lys 
    2990                 2995                 3000             


Asn Gly  Val Glu Ile Lys Ser  Thr Asp Lys Cys Gln  Met Arg Thr 
    3005                 3010                 3015             


Lys Lys  Leu Thr His Ser Leu  Asn Ile Arg Asn Val  His Phe Gly 
    3020                 3025                 3030             


Asp Ala  Ala Asp Tyr Thr Phe  Val Ala Gly Lys Ala  Thr Ser Thr 
    3035                 3040                 3045             


Ala Thr  Leu Tyr Val Glu Ala  Arg His Ile Glu Phe  Arg Lys His 
    3050                 3055                 3060             


Ile Lys  Asp Ile Lys Val Leu  Glu Lys Lys Arg Ala  Met Phe Glu 
    3065                 3070                 3075             


Cys Glu  Val Ser Glu Pro Asp  Ile Thr Val Gln Trp  Met Lys Asp 
    3080                 3085                 3090             


Asp Gln  Glu Leu Gln Ile Thr  Asp Arg Ile Lys Ile  Gln Lys Glu 
    3095                 3100                 3105             


Lys Tyr  Val His Arg Leu Leu  Ile Pro Ser Thr Arg  Met Ser Asp 
    3110                 3115                 3120             


Ala Gly  Lys Tyr Thr Val Val  Ala Gly Gly Asn Val  Ser Thr Ala 
    3125                 3130                 3135             


Lys Leu  Phe Val Glu Gly Arg  Asp Val Arg Ile Arg  Ser Ile Lys 
    3140                 3145                 3150             


Lys Glu  Val Gln Val Ile Glu  Lys Gln Arg Ala Val  Val Glu Phe 
    3155                 3160                 3165             


Glu Val  Asn Glu Asp Asp Val  Asp Ala His Trp Tyr  Lys Asp Gly 
    3170                 3175                 3180             


Ile Glu  Ile Asn Phe Gln Val  Gln Glu Arg His Lys  Tyr Val Val 
    3185                 3190                 3195             


Glu Arg  Arg Ile His Arg Met  Phe Ile Ser Glu Thr  Arg Gln Ser 
    3200                 3205                 3210             


Asp Ala  Gly Glu Tyr Thr Phe  Val Ala Gly Arg Asn  Arg Ser Ser 
    3215                 3220                 3225             


Val Thr  Leu Tyr Val Asn Ala  Pro Glu Pro Pro Gln  Val Leu Gln 
    3230                 3235                 3240             


Glu Leu  Gln Pro Val Thr Val  Gln Ser Gly Lys Pro  Ala Arg Phe 
    3245                 3250                 3255             


Cys Ala  Val Ile Ser Gly Arg  Pro Gln Pro Lys Ile  Ser Trp Tyr 
    3260                 3265                 3270             


Lys Glu  Glu Gln Leu Leu Ser  Thr Gly Phe Lys Cys  Lys Phe Leu 
    3275                 3280                 3285             


His Asp  Gly Gln Glu Tyr Thr  Leu Leu Leu Ile Glu  Ala Phe Pro 
    3290                 3295                 3300             


Glu Asp  Ala Ala Val Tyr Thr  Cys Glu Ala Lys Asn  Asp Tyr Gly 
    3305                 3310                 3315             


Val Ala  Thr Thr Ser Ala Ser  Leu Ser Val Glu Val  Pro Glu Val 
    3320                 3325                 3330             


Val Ser  Pro Asp Gln Glu Met  Pro Val Tyr Pro Pro  Ala Ile Ile 
    3335                 3340                 3345             


Thr Pro  Leu Gln Asp Thr Val  Thr Ser Glu Gly Gln  Pro Ala Arg 
    3350                 3355                 3360             


Phe Gln  Cys Arg Val Ser Gly  Thr Asp Leu Lys Val  Ser Trp Tyr 
    3365                 3370                 3375             


Ser Lys  Asp Lys Lys Ile Lys  Pro Ser Arg Phe Phe  Arg Met Thr 
    3380                 3385                 3390             


Gln Phe  Glu Asp Thr Tyr Gln  Leu Glu Ile Ala Glu  Ala Tyr Pro 
    3395                 3400                 3405             


Glu Asp  Glu Gly Thr Tyr Thr  Phe Val Ala Ser Asn  Ala Val Gly 
    3410                 3415                 3420             


Gln Val  Ser Ser Thr Ala Asn  Leu Ser Leu Glu Ala  Pro Glu Ser 
    3425                 3430                 3435             


Ile Leu  His Glu Arg Ile Glu  Gln Glu Ile Glu Met  Glu Met Lys 
    3440                 3445                 3450             


Glu Phe  Ser Ser Ser Phe Leu  Ser Ala Glu Glu Glu  Gly Leu His 
    3455                 3460                 3465             


Ser Ala  Glu Leu Gln Leu Ser  Lys Ile Asn Glu Thr  Leu Glu Leu 
    3470                 3475                 3480             


Leu Ser  Glu Ser Pro Val Tyr  Pro Thr Lys Phe Asp  Ser Glu Lys 
    3485                 3490                 3495             


Glu Gly  Thr Gly Pro Ile Phe  Ile Lys Glu Val Ser  Asn Ala Asp 
    3500                 3505                 3510             


Ile Ser  Met Gly Asp Val Ala  Thr Leu Ser Val Thr  Val Ile Gly 
    3515                 3520                 3525             


Ile Pro  Lys Pro Lys Ile Gln  Trp Phe Phe Asn Gly  Val Leu Leu 
    3530                 3535                 3540             


Thr Pro  Ser Ala Asp Tyr Lys  Phe Val Phe Asp Gly  Asp Asp His 
    3545                 3550                 3555             


Ser Leu  Ile Ile Leu Phe Thr  Lys Leu Glu Asp Glu  Gly Glu Tyr 
    3560                 3565                 3570             


Thr Cys  Met Ala Ser Asn Asp  Tyr Gly Lys Thr Ile  Cys Ser Ala 
    3575                 3580                 3585             


Tyr Leu  Lys Ile Asn Ser Lys  Gly Glu Gly His Lys  Asp Thr Glu 
    3590                 3595                 3600             


Thr Glu  Ser Ala Val Ala Lys  Ser Leu Glu Lys Leu  Gly Gly Pro 
    3605                 3610                 3615             


Cys Pro  Pro His Phe Leu Lys  Glu Leu Lys Pro Ile  Arg Cys Ala 
    3620                 3625                 3630             


Gln Gly  Leu Pro Ala Ile Phe  Glu Tyr Thr Val Val  Gly Glu Pro 
    3635                 3640                 3645             


Ala Pro  Thr Val Thr Trp Phe  Lys Glu Asn Lys Gln  Leu Cys Thr 
    3650                 3655                 3660             


Ser Val  Tyr Tyr Thr Ile Ile  His Asn Pro Asn Gly  Ser Gly Thr 
    3665                 3670                 3675             


Phe Ile  Val Asn Asp Pro Gln  Arg Glu Asp Ser Gly  Leu Tyr Ile 
    3680                 3685                 3690             


Cys Lys  Ala Glu Asn Met Leu  Gly Glu Ser Thr Cys  Ala Ala Glu 
    3695                 3700                 3705             


Leu Leu  Val Leu Leu Glu Asp  Thr Asp Met Thr Asp  Thr Pro Cys 
    3710                 3715                 3720             


Lys Ala  Lys Ser Thr Pro Glu  Ala Pro Glu Asp Phe  Pro Gln Thr 
    3725                 3730                 3735             


Pro Leu  Lys Gly Pro Ala Val  Glu Ala Leu Asp Ser  Glu Gln Glu 
    3740                 3745                 3750             


Ile Ala  Thr Phe Val Lys Asp  Thr Ile Leu Lys Ala  Ala Leu Ile 
    3755                 3760                 3765             


Thr Glu  Glu Asn Gln Gln Leu  Ser Tyr Glu His Ile  Ala Lys Ala 
    3770                 3775                 3780             


Asn Glu  Leu Ser Ser Gln Leu  Pro Leu Gly Ala Gln  Glu Leu Gln 
    3785                 3790                 3795             


Ser Ile  Leu Glu Gln Asp Lys  Leu Thr Pro Glu Ser  Thr Arg Glu 
    3800                 3805                 3810             


Phe Leu  Cys Ile Asn Gly Ser  Ile His Phe Gln Pro  Leu Lys Glu 
    3815                 3820                 3825             


Pro Ser  Pro Asn Leu Gln Leu  Gln Ile Val Gln Ser  Gln Lys Thr 
    3830                 3835                 3840             


Phe Ser  Lys Glu Gly Ile Leu  Met Pro Glu Glu Pro  Glu Thr Gln 
    3845                 3850                 3855             


Ala Val  Leu Ser Asp Thr Glu  Lys Ile Phe Pro Ser  Ala Met Ser 
    3860                 3865                 3870             


Ile Glu  Gln Ile Asn Ser Leu  Thr Val Glu Pro Leu  Lys Thr Leu 
    3875                 3880                 3885             


Leu Ala  Glu Pro Glu Gly Asn  Tyr Pro Gln Ser Ser  Ile Glu Pro 
    3890                 3895                 3900             


Pro Met  His Ser Tyr Leu Thr  Ser Val Ala Glu Glu  Val Leu Ser 
    3905                 3910                 3915             


Pro Lys  Glu Lys Thr Val Ser  Asp Thr Asn Arg Glu  Gln Arg Val 
    3920                 3925                 3930             


Thr Leu  Gln Lys Gln Glu Ala  Gln Ser Ala Leu Ile  Leu Ser Gln 
    3935                 3940                 3945             


Ser Leu  Ala Glu Gly His Val  Glu Ser Leu Gln Ser  Pro Asp Val 
    3950                 3955                 3960             


Met Ile  Ser Gln Val Asn Tyr  Glu Pro Leu Val Pro  Ser Glu His 
    3965                 3970                 3975             


Ser Cys  Thr Glu Gly Gly Lys  Ile Leu Ile Glu Ser  Ala Asn Pro 
    3980                 3985                 3990             


Leu Glu  Asn Ala Gly Gln Asp  Ser Ala Val Arg Ile  Glu Glu Gly 
    3995                 4000                 4005             


Lys Ser  Leu Arg Phe Pro Leu  Ala Leu Glu Glu Lys  Gln Val Leu 
    4010                 4015                 4020             


Leu Lys  Glu Glu His Ser Asp  Asn Val Val Met Pro  Pro Asp Gln 
    4025                 4030                 4035             


Ile Ile  Glu Ser Lys Arg Glu  Pro Val Ala Ile Lys  Lys Val Gln 
    4040                 4045                 4050             


Glu Val  Gln Gly Arg Asp Leu  Leu Ser Lys Glu Ser  Leu Leu Ser 
    4055                 4060                 4065             


Gly Ile  Pro Glu Glu Gln Arg  Leu Asn Leu Lys Ile  Gln Ile Cys 
    4070                 4075                 4080             


Arg Ala  Leu Gln Ala Ala Val  Ala Ser Glu Gln Pro  Gly Leu Phe 
    4085                 4090                 4095             


Ser Glu  Trp Leu Arg Asn Ile  Glu Lys Val Glu Val  Glu Ala Val 
    4100                 4105                 4110             


Asn Ile  Thr Gln Glu Pro Arg  His Ile Met Cys Met  Tyr Leu Val 
    4115                 4120                 4125             


Thr Ser  Ala Lys Ser Val Thr  Glu Glu Val Thr Ile  Ile Ile Glu 
    4130                 4135                 4140             


Asp Val  Asp Pro Gln Met Ala  Asn Leu Lys Met Glu  Leu Arg Asp 
    4145                 4150                 4155             


Ala Leu  Cys Ala Ile Ile Tyr  Glu Glu Ile Asp Ile  Leu Thr Ala 
    4160                 4165                 4170             


Glu Gly  Pro Arg Ile Gln Gln  Gly Ala Lys Thr Ser  Leu Gln Glu 
    4175                 4180                 4185             


Glu Met  Asp Ser Phe Ser Gly  Ser Gln Lys Val Glu  Pro Ile Thr 
    4190                 4195                 4200             


Glu Pro  Glu Val Glu Ser Lys  Tyr Leu Ile Ser Thr  Glu Glu Val 
    4205                 4210                 4215             


Ser Tyr  Phe Asn Val Gln Ser  Arg Val Lys Tyr Leu  Asp Ala Thr 
    4220                 4225                 4230             


Pro Val  Thr Lys Gly Val Ala  Ser Ala Val Val Ser  Asp Glu Lys 
    4235                 4240                 4245             


Gln Asp  Glu Ser Leu Lys Pro  Ser Glu Glu Lys Glu  Glu Ser Ser 
    4250                 4255                 4260             


Ser Glu  Ser Gly Thr Glu Glu  Val Ala Thr Val Lys  Ile Gln Glu 
    4265                 4270                 4275             


Ala Glu  Gly Gly Leu Ile Lys  Glu Asp Gly Pro Met  Ile His Thr 
    4280                 4285                 4290             


Pro Leu  Val Asp Thr Val Ser  Glu Glu Gly Asp Ile  Val His Leu 
    4295                 4300                 4305             


Thr Thr  Ser Ile Thr Asn Ala  Lys Glu Val Asn Trp  Tyr Phe Glu 
    4310                 4315                 4320             


Asn Lys  Leu Val Pro Ser Asp  Glu Lys Phe Lys Cys  Leu Gln Asp 
    4325                 4330                 4335             


Gln Asn  Thr Tyr Thr Leu Val  Ile Asp Lys Val Asn  Thr Glu Asp 
    4340                 4345                 4350             


His Gln  Gly Glu Tyr Val Cys  Glu Ala Leu Asn Asp  Ser Gly Lys 
    4355                 4360                 4365             


Thr Ala  Thr Ser Ala Lys Leu  Thr Val Val Lys Arg  Ala Ala Pro 
    4370                 4375                 4380             


Val Ile  Lys Arg Lys Ile Glu  Pro Leu Glu Val Ala  Leu Gly His 
    4385                 4390                 4395             


Leu Ala  Lys Phe Thr Cys Glu  Ile Gln Ser Ala Pro  Asn Val Arg 
    4400                 4405                 4410             


Phe Gln  Trp Phe Lys Ala Gly  Arg Glu Ile Tyr Glu  Ser Asp Lys 
    4415                 4420                 4425             


Cys Ser  Ile Arg Ser Ser Lys  Tyr Ile Ser Ser Leu  Glu Ile Leu 
    4430                 4435                 4440             


Arg Thr  Gln Val Val Asp Cys  Gly Glu Tyr Thr Cys  Lys Ala Ser 
    4445                 4450                 4455             


Asn Glu  Tyr Gly Ser Val Ser  Cys Thr Ala Thr Leu  Thr Val Thr 
    4460                 4465                 4470             


Glu Ala  Tyr Pro Pro Thr Phe  Leu Ser Arg Pro Lys  Ser Leu Thr 
    4475                 4480                 4485             


Thr Phe  Val Gly Lys Ala Ala  Lys Phe Ile Cys Thr  Val Thr Gly 
    4490                 4495                 4500             


Thr Pro  Val Ile Glu Thr Ile  Trp Gln Lys Asp Gly  Ala Ala Leu 
    4505                 4510                 4515             


Ser Pro  Ser Pro Asn Trp Arg  Ile Ser Asp Ala Glu  Asn Lys His 
    4520                 4525                 4530             


Ile Leu  Glu Leu Ser Asn Leu  Thr Ile Gln Asp Arg  Gly Val Tyr 
    4535                 4540                 4545             


Ser Cys  Lys Ala Ser Asn Lys  Phe Gly Ala Asp Ile  Cys Gln Ala 
    4550                 4555                 4560             


Glu Leu  Ile Ile Ile Asp Lys  Pro His Phe Ile Lys  Glu Leu Glu 
    4565                 4570                 4575             


Pro Val  Gln Ser Ala Ile Asn  Lys Lys Val His Leu  Glu Cys Gln 
    4580                 4585                 4590             


Val Asp  Glu Asp Arg Lys Val  Thr Val Thr Trp Ser  Lys Asp Gly 
    4595                 4600                 4605             


Gln Lys  Leu Pro Pro Gly Lys  Asp Tyr Lys Ile Cys  Phe Glu Asp 
    4610                 4615                 4620             


Lys Ile  Ala Thr Leu Glu Ile  Pro Leu Ala Lys Leu  Lys Asp Ser 
    4625                 4630                 4635             


Gly Thr  Tyr Val Cys Thr Ala  Ser Asn Glu Ala Gly  Ser Ser Ser 
    4640                 4645                 4650             


Cys Ser  Ala Thr Val Thr Val  Arg Glu Pro Pro Ser  Phe Val Lys 
    4655                 4660                 4665             


Lys Val  Asp Pro Ser Tyr Leu  Met Leu Pro Gly Glu  Ser Ala Arg 
    4670                 4675                 4680             


Leu His  Cys Lys Leu Lys Gly  Ser Pro Val Ile Gln  Val Thr Trp 
    4685                 4690                 4695             


Phe Lys  Asn Asn Lys Glu Leu  Ser Glu Ser Asn Thr  Val Arg Met 
    4700                 4705                 4710             


Tyr Phe  Val Asn Ser Glu Ala  Ile Leu Asp Ile Thr  Asp Val Lys 
    4715                 4720                 4725             


Val Glu  Asp Ser Gly Ser Tyr  Ser Cys Glu Ala Val  Asn Asp Val 
    4730                 4735                 4740             


Gly Ser  Asp Ser Cys Ser Thr  Glu Ile Val Ile Lys  Glu Pro Pro 
    4745                 4750                 4755             


Ser Phe  Ile Lys Thr Leu Glu  Pro Ala Asp Ile Val  Arg Gly Thr 
    4760                 4765                 4770             


Asn Ala  Leu Leu Gln Cys Glu  Val Ser Gly Thr Gly  Pro Phe Glu 
    4775                 4780                 4785             


Ile Ser  Trp Phe Lys Asp Lys  Lys Gln Ile Arg Ser  Ser Lys Lys 
    4790                 4795                 4800             


Tyr Arg  Leu Phe Ser Gln Lys  Ser Leu Val Cys Leu  Glu Ile Phe 
    4805                 4810                 4815             


Ser Phe  Asn Ser Ala Asp Val  Gly Glu Tyr Glu Cys  Val Val Ala 
    4820                 4825                 4830             


Asn Glu  Val Gly Lys Cys Gly  Cys Met Ala Thr His  Leu Leu Lys 
    4835                 4840                 4845             


Glu Pro  Pro Thr Phe Val Lys  Lys Val Asp Asp Leu  Ile Ala Leu 
    4850                 4855                 4860             


Gly Gly  Gln Thr Val Thr Leu  Gln Ala Ala Val Arg  Gly Ser Glu 
    4865                 4870                 4875             


Pro Ile  Ser Val Thr Trp Met  Lys Gly Gln Glu Val  Ile Arg Glu 
    4880                 4885                 4890             


Asp Gly  Lys Ile Lys Met Ser  Phe Ser Asn Gly Val  Ala Val Leu 
    4895                 4900                 4905             


Ile Ile  Pro Asp Val Gln Ile  Ser Phe Gly Gly Lys  Tyr Thr Cys 
    4910                 4915                 4920             


Leu Ala  Glu Asn Glu Ala Gly  Ser Gln Thr Ser Val  Gly Glu Leu 
    4925                 4930                 4935             


Ile Val  Lys Glu Pro Ala Lys  Ile Ile Glu Arg Ala  Glu Leu Ile 
    4940                 4945                 4950             


Gln Val  Thr Ala Gly Asp Pro  Ala Thr Leu Glu Tyr  Thr Val Ala 
    4955                 4960                 4965             


Gly Thr  Pro Glu Leu Lys Pro  Lys Trp Tyr Lys Asp  Gly Arg Pro 
    4970                 4975                 4980             


Leu Val  Ala Ser Lys Lys Tyr  Arg Ile Ser Phe Lys  Asn Asn Val 
    4985                 4990                 4995             


Ala Gln  Leu Lys Phe Tyr Ser  Ala Glu Leu His Asp  Ser Gly Gln 
    5000                 5005                 5010             


Tyr Thr  Phe Glu Ile Ser Asn  Glu Val Gly Ser Ser  Ser Cys Glu 
    5015                 5020                 5025             


Thr Thr  Phe Thr Val Leu Asp  Arg Asp Ile Ala Pro  Phe Phe Thr 
    5030                 5035                 5040             


Lys Pro  Leu Arg Asn Val Asp  Ser Val Val Asn Gly  Thr Cys Arg 
    5045                 5050                 5055             


Leu Asp  Cys Lys Ile Ala Gly  Ser Leu Pro Met Arg  Val Ser Trp 
    5060                 5065                 5070             


Phe Lys  Asp Gly Lys Glu Ile  Ala Ala Ser Asp Arg  Tyr Arg Ile 
    5075                 5080                 5085             


Ala Phe  Val Glu Gly Thr Ala  Ser Leu Glu Ile Ile  Arg Val Asp 
    5090                 5095                 5100             


Met Asn  Asp Ala Gly Asn Phe  Thr Cys Arg Ala Thr  Asn Ser Val 
    5105                 5110                 5115             


Gly Ser  Lys Asp Ser Ser Gly  Ala Leu Ile Val Gln  Glu Pro Pro 
    5120                 5125                 5130             


Ser Phe  Val Thr Lys Pro Gly  Ser Lys Asp Val Leu  Pro Gly Ser 
    5135                 5140                 5145             


Ala Val  Cys Leu Lys Ser Thr  Phe Gln Gly Ser Thr  Pro Leu Thr 
    5150                 5155                 5160             


Ile Arg  Trp Phe Lys Gly Asn  Lys Glu Leu Val Ser  Gly Gly Ser 
    5165                 5170                 5175             


Cys Tyr  Ile Thr Lys Glu Ala  Leu Glu Ser Ser Leu  Glu Leu Tyr 
    5180                 5185                 5190             


Leu Val  Lys Thr Ser Asp Ser  Gly Thr Tyr Thr Cys  Lys Val Ser 
    5195                 5200                 5205             


Asn Val  Ala Gly Gly Val Glu  Cys Ser Ala Asn Leu  Phe Val Lys 
    5210                 5215                 5220             


Glu Pro  Ala Thr Phe Val Glu  Lys Leu Glu Pro Ser  Gln Leu Leu 
    5225                 5230                 5235             


Lys Lys  Gly Asp Ala Thr Gln  Leu Ala Cys Lys Val  Thr Gly Thr 
    5240                 5245                 5250             


Pro Pro  Ile Lys Ile Thr Trp  Phe Ala Asn Asp Arg  Glu Ile Lys 
    5255                 5260                 5265             


Glu Ser  Ser Lys His Arg Met  Ser Phe Val Glu Ser  Thr Ala Val 
    5270                 5275                 5280             


Leu Arg  Leu Thr Asp Val Gly  Ile Glu Asp Ser Gly  Glu Tyr Met 
    5285                 5290                 5295             


Cys Glu  Ala Gln Asn Glu Ala  Gly Ser Asp His Cys  Ser Ser Ile 
    5300                 5305                 5310             


Val Ile  Val Lys Glu Ser Pro  Tyr Phe Thr Lys Glu  Phe Lys Pro 
    5315                 5320                 5325             


Ile Glu  Val Leu Lys Glu Tyr  Asp Val Met Leu Leu  Ala Glu Val 
    5330                 5335                 5340             


Ala Gly  Thr Pro Pro Phe Glu  Ile Thr Trp Phe Lys  Asp Asn Thr 
    5345                 5350                 5355             


Ile Leu  Arg Ser Gly Arg Lys  Tyr Lys Thr Phe Ile  Gln Asp His 
    5360                 5365                 5370             


Leu Val  Ser Leu Gln Ile Leu  Lys Phe Val Ala Ala  Asp Ala Gly 
    5375                 5380                 5385             


Glu Tyr  Gln Cys Arg Val Thr  Asn Glu Val Gly Ser  Ser Ile Cys 
    5390                 5395                 5400             


Ser Ala  Arg Val Thr Leu Arg  Glu Pro Pro Ser Phe  Ile Lys Lys 
    5405                 5410                 5415             


Ile Glu  Ser Thr Ser Ser Leu  Arg Gly Gly Thr Ala  Ala Phe Gln 
    5420                 5425                 5430             


Ala Thr  Leu Lys Gly Ser Leu  Pro Ile Thr Val Thr  Trp Leu Lys 
    5435                 5440                 5445             


Asp Ser  Asp Glu Ile Thr Glu  Asp Asp Asn Ile Arg  Met Thr Phe 
    5450                 5455                 5460             


Glu Asn  Asn Val Ala Ser Leu  Tyr Leu Ser Gly Ile  Glu Val Lys 
    5465                 5470                 5475             


His Asp  Gly Lys Tyr Val Cys  Gln Ala Lys Asn Asp  Ala Gly Ile 
    5480                 5485                 5490             


Gln Arg  Cys Ser Ala Leu Leu  Ser Val Lys Glu Pro  Ala Thr Ile 
    5495                 5500                 5505             


Thr Glu  Glu Ala Val Ser Ile  Asp Val Thr Gln Gly  Asp Pro Ala 
    5510                 5515                 5520             


Thr Leu  Gln Val Lys Phe Ser  Gly Thr Lys Glu Ile  Thr Ala Lys 
    5525                 5530                 5535             


Trp Phe  Lys Asp Gly Gln Glu  Leu Thr Leu Gly Ser  Lys Tyr Lys 
    5540                 5545                 5550             


Ile Ser  Val Thr Asp Thr Val  Ser Ile Leu Lys Ile  Ile Ser Thr 
    5555                 5560                 5565             


Glu Lys  Lys Asp Ser Gly Glu  Tyr Thr Phe Glu Val  Gln Asn Asp 
    5570                 5575                 5580             


Val Gly  Arg Ser Ser Cys Lys  Ala Arg Ile Asn Val  Leu Asp Leu 
    5585                 5590                 5595             


Ile Ile  Pro Pro Ser Phe Thr  Lys Lys Leu Lys Lys  Met Asp Ser 
    5600                 5605                 5610             


Ile Lys  Gly Ser Phe Ile Asp  Leu Glu Cys Ile Val  Ala Gly Ser 
    5615                 5620                 5625             


His Pro  Ile Ser Ile Gln Trp  Phe Lys Asp Asp Gln  Glu Ile Ser 
    5630                 5635                 5640             


Ala Ser  Glu Lys Tyr Lys Phe  Ser Phe His Asp Asn  Thr Ala Phe 
    5645                 5650                 5655             


Leu Glu  Ile Ser Gln Leu Glu  Gly Thr Asp Ser Gly  Thr Tyr Thr 
    5660                 5665                 5670             


Cys Ser  Ala Thr Asn Lys Ala  Gly His Asn Gln Cys  Ser Gly His 
    5675                 5680                 5685             


Leu Thr  Val Lys Glu Pro Pro  Tyr Phe Val Glu Lys  Pro Gln Ser 
    5690                 5695                 5700             


Gln Asp  Val Asn Pro Asn Thr  Arg Val Gln Leu Lys  Ala Leu Val 
    5705                 5710                 5715             


Gly Gly  Thr Ala Pro Met Thr  Ile Lys Trp Phe Lys  Asp Asn Lys 
    5720                 5725                 5730             


Glu Leu  His Ser Gly Ala Ala  Arg Ser Val Trp Lys  Asp Asp Thr 
    5735                 5740                 5745             


Ser Thr  Ser Leu Glu Leu Phe  Ala Ala Lys Ala Thr  Asp Ser Gly 
    5750                 5755                 5760             


Thr Tyr  Ile Cys Gln Leu Ser  Asn Asp Val Gly Thr  Ala Thr Ser 
    5765                 5770                 5775             


Lys Ala  Thr Leu Phe Val Lys  Glu Pro Pro Gln Phe  Ile Lys Lys 
    5780                 5785                 5790             


Pro Ser  Pro Val Leu Val Leu  Arg Asn Gly Gln Ser  Thr Thr Phe 
    5795                 5800                 5805             


Glu Cys  Gln Ile Thr Gly Thr  Pro Lys Ile Arg Val  Ser Trp Tyr 
    5810                 5815                 5820             


Leu Asp  Gly Asn Glu Ile Thr  Ala Ile Gln Lys His  Gly Ile Ser 
    5825                 5830                 5835             


Phe Ile  Asp Gly Leu Ala Thr  Phe Gln Ile Ser Gly  Ala Arg Val 
    5840                 5845                 5850             


Glu Asn  Ser Gly Thr Tyr Val  Cys Glu Ala Arg Asn  Asp Ala Gly 
    5855                 5860                 5865             


Thr Ala  Ser Cys Ser Ile Glu  Leu Lys Val Lys Glu  Pro Pro Thr 
    5870                 5875                 5880             


Phe Ile  Arg Glu Leu Lys Pro  Val Glu Val Val Lys  Tyr Ser Asp 
    5885                 5890                 5895             


Val Glu  Leu Glu Cys Glu Val  Thr Gly Thr Pro Pro  Phe Glu Val 
    5900                 5905                 5910             


Thr Trp  Leu Lys Asn Asn Arg  Glu Ile Arg Ser Ser  Lys Lys Tyr 
    5915                 5920                 5925             


Thr Leu  Thr Asp Arg Val Ser  Val Phe Asn Leu His  Ile Thr Lys 
    5930                 5935                 5940             


Cys Asp  Pro Ser Asp Thr Gly  Glu Tyr Gln Cys Ile  Val Ser Asn 
    5945                 5950                 5955             


Glu Gly  Gly Ser Cys Ser Cys  Ser Thr Arg Val Ala  Leu Lys Glu 
    5960                 5965                 5970             


Pro Pro  Ser Phe Ile Lys Lys  Ile Glu Asn Thr Thr  Thr Val Leu 
    5975                 5980                 5985             


Lys Ser  Ser Ala Thr Phe Gln  Ser Thr Val Ala Gly  Ser Pro Pro 
    5990                 5995                 6000             


Ile Ser  Ile Thr Trp Leu Lys  Asp Asp Gln Ile Leu  Asp Glu Asp 
    6005                 6010                 6015             


Asp Asn  Val Tyr Ile Ser Phe  Val Asp Ser Val Ala  Thr Leu Gln 
    6020                 6025                 6030             


Ile Arg  Ser Val Asp Asn Gly  His Ser Gly Arg Tyr  Thr Cys Gln 
    6035                 6040                 6045             


Ala Lys  Asn Glu Ser Gly Val  Glu Arg Cys Tyr Ala  Phe Leu Leu 
    6050                 6055                 6060             


Val Gln  Glu Pro Ala Gln Ile  Val Glu Lys Ala Lys  Ser Val Asp 
    6065                 6070                 6075             


Val Thr  Glu Lys Asp Pro Met  Thr Leu Glu Cys Val  Val Ala Gly 
    6080                 6085                 6090             


Thr Pro  Glu Leu Lys Val Lys  Trp Leu Lys Asp Gly  Lys Gln Ile 
    6095                 6100                 6105             


Val Pro  Ser Arg Tyr Phe Ser  Met Ser Phe Glu Asn  Asn Val Ala 
    6110                 6115                 6120             


Ser Phe  Arg Ile Gln Ser Val  Met Lys Gln Asp Ser  Gly Gln Tyr 
    6125                 6130                 6135             


Thr Phe  Lys Val Glu Asn Asp  Phe Gly Ser Ser Ser  Cys Asp Ala 
    6140                 6145                 6150             


Tyr Leu  Arg Val Leu Asp Gln  Asn Ile Pro Pro Ser  Phe Thr Lys 
    6155                 6160                 6165             


Lys Leu  Thr Lys Met Asp Lys  Val Leu Gly Ser Ser  Ile His Met 
    6170                 6175                 6180             


Glu Cys  Lys Val Ser Gly Ser  Leu Pro Ile Ser Ala  Gln Trp Phe 
    6185                 6190                 6195             


Lys Asp  Gly Lys Glu Ile Ser  Thr Ser Ala Lys Tyr  Arg Leu Val 
    6200                 6205                 6210             


Cys His  Glu Arg Ser Val Ser  Leu Glu Val Asn Asn  Leu Glu Leu 
    6215                 6220                 6225             


Glu Asp  Thr Ala Asn Tyr Thr  Cys Lys Val Ser Asn  Val Ala Gly 
    6230                 6235                 6240             


Asp Asp  Ala Cys Ser Gly Ile  Leu Thr Val Lys Glu  Pro Pro Ser 
    6245                 6250                 6255             


Phe Leu  Val Lys Pro Gly Arg  Gln Gln Ala Ile Pro  Asp Ser Thr 
    6260                 6265                 6270             


Val Glu  Phe Lys Ala Ile Leu  Lys Gly Thr Pro Pro  Phe Lys Ile 
    6275                 6280                 6285             


Lys Trp  Phe Lys Asp Asp Val  Glu Leu Val Ser Gly  Pro Lys Cys 
    6290                 6295                 6300             


Phe Ile  Gly Leu Glu Gly Ser  Thr Ser Phe Leu Asn  Leu Tyr Ser 
    6305                 6310                 6315             


Val Asp  Ala Ser Lys Thr Gly  Gln Tyr Thr Cys His  Val Thr Asn 
    6320                 6325                 6330             


Asp Val  Gly Ser Asp Ser Cys  Thr Thr Met Leu Leu  Val Thr Glu 
    6335                 6340                 6345             


Pro Pro  Lys Phe Val Lys Lys  Leu Glu Ala Ser Lys  Ile Val Lys 
    6350                 6355                 6360             


Ala Gly  Asp Ser Ser Arg Leu  Glu Cys Lys Ile Ala  Gly Ser Pro 
    6365                 6370                 6375             


Glu Ile  Arg Val Val Trp Phe  Arg Asn Glu His Glu  Leu Pro Ala 
    6380                 6385                 6390             


Ser Asp  Lys Tyr Arg Met Thr  Phe Ile Asp Ser Val  Ala Val Ile 
    6395                 6400                 6405             


Gln Met  Asn Asn Leu Ser Thr  Glu Asp Ser Gly Asp  Phe Ile Cys 
    6410                 6415                 6420             


Glu Ala  Gln Asn Pro Ala Gly  Ser Thr Ser Cys Ser  Thr Lys Val 
    6425                 6430                 6435             


Ile Val  Lys Glu Pro Pro Val  Phe Ser Ser Phe Pro  Pro Ile Val 
    6440                 6445                 6450             


Glu Thr  Leu Lys Asn Ala Glu  Val Ser Leu Glu Cys  Glu Leu Ser 
    6455                 6460                 6465             


Gly Thr  Pro Pro Phe Glu Val  Val Trp Tyr Lys Asp  Lys Arg Gln 
    6470                 6475                 6480             


Leu Arg  Ser Ser Lys Lys Tyr  Lys Ile Ala Ser Lys  Asn Phe His 
    6485                 6490                 6495             


Thr Ser  Ile His Ile Leu Asn  Val Asp Thr Ser Asp  Ile Gly Glu 
    6500                 6505                 6510             


Tyr His  Cys Lys Ala Gln Asn  Glu Val Gly Ser Asp  Thr Cys Val 
    6515                 6520                 6525             


Cys Thr  Val Lys Leu Lys Glu  Pro Pro Arg Phe Val  Ser Lys Leu 
    6530                 6535                 6540             


Asn Ser  Leu Thr Val Val Ala  Gly Glu Pro Ala Glu  Leu Gln Ala 
    6545                 6550                 6555             


Ser Ile  Glu Gly Ala Gln Pro  Ile Phe Val Gln Trp  Leu Lys Glu 
    6560                 6565                 6570             


Lys Glu  Glu Val Ile Arg Glu  Ser Glu Asn Ile Arg  Ile Thr Phe 
    6575                 6580                 6585             


Val Glu  Asn Val Ala Thr Leu  Gln Phe Ala Lys Ala  Glu Pro Ala 
    6590                 6595                 6600             


Asn Ala  Gly Lys Tyr Ile Cys  Gln Ile Lys Asn Asp  Gly Gly Met 
    6605                 6610                 6615             


Arg Glu  Asn Met Ala Thr Leu  Met Val Leu Glu Pro  Ala Val Ile 
    6620                 6625                 6630             


Val Glu  Lys Ala Gly Pro Met  Thr Val Thr Val Gly  Glu Thr Cys 
    6635                 6640                 6645             


Thr Leu  Glu Cys Lys Val Ala  Gly Thr Pro Glu Leu  Ser Val Glu 
    6650                 6655                 6660             


Trp Tyr  Lys Asp Gly Lys Leu  Leu Thr Ser Ser Gln  Lys His Lys 
    6665                 6670                 6675             


Phe Ser  Phe Tyr Asn Lys Ile  Ser Ser Leu Arg Ile  Leu Ser Val 
    6680                 6685                 6690             


Glu Arg  Gln Asp Ala Gly Thr  Tyr Thr Phe Gln Val  Gln Asn Asn 
    6695                 6700                 6705             


Val Gly  Lys Ser Ser Cys Thr  Ala Val Val Asp Val  Ser Asp Arg 
    6710                 6715                 6720             


Ala Val  Pro Pro Ser Phe Thr  Arg Arg Leu Lys Asn  Thr Gly Gly 
    6725                 6730                 6735             


Val Leu  Gly Ala Ser Cys Ile  Leu Glu Cys Lys Val  Ala Gly Ser 
    6740                 6745                 6750             


Ser Pro  Ile Ser Val Ala Trp  Phe His Glu Lys Thr  Lys Ile Val 
    6755                 6760                 6765             


Ser Gly  Ala Lys Tyr Gln Thr  Thr Phe Ser Asp Asn  Val Cys Thr 
    6770                 6775                 6780             


Leu Gln  Leu Asn Ser Leu Asp  Ser Ser Asp Met Gly  Asn Tyr Thr 
    6785                 6790                 6795             


Cys Val  Ala Ala Asn Val Ala  Gly Ser Asp Glu Cys  Arg Ala Val 
    6800                 6805                 6810             


Leu Thr  Val Gln Glu Pro Pro  Ser Phe Val Lys Glu  Pro Glu Pro 
    6815                 6820                 6825             


Leu Glu  Val Leu Pro Gly Lys  Asn Val Thr Phe Thr  Ser Val Ile 
    6830                 6835                 6840             


Arg Gly  Thr Pro Pro Phe Lys  Val Asn Trp Phe Arg  Gly Ala Arg 
    6845                 6850                 6855             


Glu Leu  Val Lys Gly Asp Arg  Cys Asn Ile Tyr Phe  Glu Asp Thr 
    6860                 6865                 6870             


Val Ala  Glu Leu Glu Leu Phe  Asn Ile Asp Ile Ser  Gln Ser Gly 
    6875                 6880                 6885             


Glu Tyr  Thr Cys Val Val Ser  Asn Asn Ala Gly Gln  Ala Ser Cys 
    6890                 6895                 6900             


Thr Thr  Arg Leu Phe Val Lys  Glu Pro Ala Ala Phe  Leu Lys Arg 
    6905                 6910                 6915             


Leu Ser  Asp His Ser Val Glu  Pro Gly Lys Ser Ile  Ile Leu Glu 
    6920                 6925                 6930             


Ser Thr  Tyr Thr Gly Thr Leu  Pro Ile Ser Val Thr  Trp Lys Lys 
    6935                 6940                 6945             


Asp Gly  Phe Asn Ile Thr Thr  Ser Glu Lys Cys Asn  Ile Val Thr 
    6950                 6955                 6960             


Thr Glu  Lys Thr Cys Ile Leu  Glu Ile Leu Asn Ser  Thr Lys Arg 
    6965                 6970                 6975             


Asp Ala  Gly Gln Tyr Ser Cys  Glu Ile Glu Asn Glu  Ala Gly Arg 
    6980                 6985                 6990             


Asp Val  Cys Gly Ala Leu Val  Ser Thr Leu Glu Pro  Pro Tyr Phe 
    6995                 7000                 7005             


Val Thr  Glu Leu Glu Pro Leu  Glu Ala Ala Val Gly  Asp Ser Val 
    7010                 7015                 7020             


Ser Leu  Gln Cys Gln Val Ala  Gly Thr Pro Glu Ile  Thr Val Ser 
    7025                 7030                 7035             


Trp Tyr  Lys Gly Asp Thr Lys  Leu Arg Pro Thr Pro  Glu Tyr Arg 
    7040                 7045                 7050             


Thr Tyr  Phe Thr Asn Asn Val  Ala Thr Leu Val Phe  Asn Lys Val 
    7055                 7060                 7065             


Asn Ile  Asn Asp Ser Gly Glu  Tyr Thr Cys Lys Ala  Glu Asn Ser 
    7070                 7075                 7080             


Ile Gly  Thr Ala Ser Ser Lys  Thr Val Phe Arg Ile  Gln Glu Arg 
    7085                 7090                 7095             


Gln Leu  Pro Pro Ser Phe Ala  Arg Gln Leu Lys Asp  Ile Glu Gln 
    7100                 7105                 7110             


Thr Val  Gly Leu Pro Val Thr  Leu Thr Cys Arg Leu  Asn Gly Ser 
    7115                 7120                 7125             


Ala Pro  Ile Gln Val Cys Trp  Tyr Arg Asp Gly Val  Leu Leu Arg 
    7130                 7135                 7140             


Asp Asp  Glu Asn Leu Gln Thr  Ser Phe Val Asp Asn  Val Ala Thr 
    7145                 7150                 7155             


Leu Lys  Ile Leu Gln Thr Asp  Leu Ser His Ser Gly  Gln Tyr Ser 
    7160                 7165                 7170             


Cys Ser  Ala Ser Asn Pro Leu  Gly Thr Ala Ser Ser  Ser Ala Arg 
    7175                 7180                 7185             


Leu Thr  Ala Arg Glu Pro Lys  Lys Ser Pro Phe Phe  Asp Ile Lys 
    7190                 7195                 7200             


Pro Val  Ser Ile Asp Val Ile  Ala Gly Glu Ser Ala  Asp Phe Glu 
    7205                 7210                 7215             


Cys His  Val Thr Gly Ala Gln  Pro Met Arg Ile Thr  Trp Ser Lys 
    7220                 7225                 7230             


Asp Asn  Lys Glu Ile Arg Pro  Gly Gly Asn Tyr Thr  Ile Thr Cys 
    7235                 7240                 7245             


Val Gly  Asn Thr Pro His Leu  Arg Ile Leu Lys Val  Gly Lys Gly 
    7250                 7255                 7260             


Asp Ser  Gly Gln Tyr Thr Cys  Gln Ala Thr Asn Asp  Val Gly Lys 
    7265                 7270                 7275             


Asp Met  Cys Ser Ala Gln Leu  Ser Val Lys Glu Pro  Pro Lys Phe 
    7280                 7285                 7290             


Val Lys  Lys Leu Glu Ala Ser  Lys Val Ala Lys Gln  Gly Glu Ser 
    7295                 7300                 7305             


Ile Gln  Leu Glu Cys Lys Ile  Ser Gly Ser Pro Glu  Ile Lys Val 
    7310                 7315                 7320             


Ser Trp  Phe Arg Asn Asp Ser  Glu Leu His Glu Ser  Trp Lys Tyr 
    7325                 7330                 7335             


Asn Met  Ser Phe Ile Asn Ser  Val Ala Leu Leu Thr  Ile Asn Glu 
    7340                 7345                 7350             


Ala Ser  Ala Glu Asp Ser Gly  Asp Tyr Ile Cys Glu  Ala His Asn 
    7355                 7360                 7365             


Gly Val  Gly Asp Ala Ser Cys  Ser Thr Ala Leu Thr  Val Lys Ala 
    7370                 7375                 7380             


Pro Pro  Val Phe Thr Gln Lys  Pro Ser Pro Val Gly  Ala Leu Lys 
    7385                 7390                 7395             


Gly Ser  Asp Val Ile Leu Gln  Cys Glu Ile Ser Gly  Thr Pro Pro 
    7400                 7405                 7410             


Phe Glu  Val Val Trp Val Lys  Asp Arg Lys Gln Val  Arg Asn Ser 
    7415                 7420                 7425             


Lys Lys  Phe Lys Ile Thr Ser  Lys His Phe Asp Thr  Ser Leu His 
    7430                 7435                 7440             


Ile Leu  Asn Leu Glu Ala Ser  Asp Val Gly Glu Tyr  His Cys Lys 
    7445                 7450                 7455             


Ala Thr  Asn Glu Val Gly Ser  Asp Thr Cys Ser Cys  Ser Val Lys 
    7460                 7465                 7470             


Phe Lys  Glu Pro Pro Arg Phe  Val Lys Lys Leu Ser  Asp Thr Ser 
    7475                 7480                 7485             


Thr Leu  Ile Gly Asp Ala Val  Glu Leu Arg Ala Ile  Val Glu Gly 
    7490                 7495                 7500             


Phe Gln  Pro Ile Ser Val Val  Trp Leu Lys Asp Arg  Gly Glu Val 
    7505                 7510                 7515             


Ile Arg  Glu Ser Glu Asn Thr  Arg Ile Ser Phe Ile  Asp Asn Ile 
    7520                 7525                 7530             


Ala Thr  Leu Gln Leu Gly Ser  Pro Glu Ala Ser Asn  Ser Gly Lys 
    7535                 7540                 7545             


Tyr Ile  Cys Gln Ile Lys Asn  Asp Ala Gly Met Arg  Glu Cys Ser 
    7550                 7555                 7560             


Ala Val  Leu Thr Val Leu Glu  Pro Ala Arg Ile Ile  Glu Lys Pro 
    7565                 7570                 7575             


Glu Pro  Met Thr Val Thr Thr  Gly Asn Pro Phe Ala  Leu Glu Cys 
    7580                 7585                 7590             


Val Val  Thr Gly Thr Pro Glu  Leu Ser Ala Lys Trp  Phe Lys Asp 
    7595                 7600                 7605             


Gly Arg  Glu Leu Ser Ala Asp  Ser Lys His His Ile  Thr Phe Ile 
    7610                 7615                 7620             


Asn Lys  Val Ala Ser Leu Lys  Ile Pro Cys Ala Glu  Met Ser Asp 
    7625                 7630                 7635             


Lys Gly  Leu Tyr Ser Phe Glu  Val Lys Asn Ser Val  Gly Lys Ser 
    7640                 7645                 7650             


Asn Cys  Thr Val Ser Val His  Val Ser Asp Arg Ile  Val Pro Pro 
    7655                 7660                 7665             


Ser Phe  Ile Arg Lys Leu Lys  Asp Val Asn Ala Ile  Leu Gly Ala 
    7670                 7675                 7680             


Ser Val  Val Leu Glu Cys Arg  Val Ser Gly Ser Ala  Pro Ile Ser 
    7685                 7690                 7695             


Val Gly  Trp Phe Gln Asp Gly  Asn Glu Ile Val Ser  Gly Pro Lys 
    7700                 7705                 7710             


Cys Gln  Ser Ser Phe Ser Glu  Asn Val Cys Thr Leu  Asn Leu Ser 
    7715                 7720                 7725             


Leu Leu  Glu Pro Ser Asp Thr  Gly Ile Tyr Thr Cys  Val Ala Ala 
    7730                 7735                 7740             


Asn Val  Ala Gly Ser Asp Glu  Cys Ser Ala Val Leu  Thr Val Gln 
    7745                 7750                 7755             


Glu Pro  Pro Ser Phe Glu Gln  Thr Pro Asp Ser Val  Glu Val Leu 
    7760                 7765                 7770             


Pro Gly  Met Ser Leu Thr Phe  Thr Ser Val Ile Arg  Gly Thr Pro 
    7775                 7780                 7785             


Pro Phe  Lys Val Lys Trp Phe  Lys Gly Ser Arg Glu  Leu Val Pro 
    7790                 7795                 7800             


Gly Glu  Ser Cys Asn Ile Ser  Leu Glu Asp Phe Val  Thr Glu Leu 
    7805                 7810                 7815             


Glu Leu  Phe Glu Val Gln Pro  Leu Glu Ser Gly Asp  Tyr Ser Cys 
    7820                 7825                 7830             


Leu Val  Thr Asn Asp Ala Gly  Ser Ala Ser Cys Thr  Thr His Leu 
    7835                 7840                 7845             


Phe Val  Lys Glu Pro Ala Thr  Phe Val Lys Arg Leu  Ala Asp Phe 
    7850                 7855                 7860             


Ser Val  Glu Thr Gly Ser Pro  Ile Val Leu Glu Ala  Thr Tyr Thr 
    7865                 7870                 7875             


Gly Thr  Pro Pro Ile Ser Val  Ser Trp Ile Lys Asp  Glu Tyr Leu 
    7880                 7885                 7890             


Ile Ser  Gln Ser Glu Arg Cys  Ser Ile Thr Met Thr  Glu Lys Ser 
    7895                 7900                 7905             


Thr Ile  Leu Glu Ile Leu Glu  Ser Thr Ile Glu Asp  Tyr Ala Gln 
    7910                 7915                 7920             


Tyr Ser  Cys Leu Ile Glu Asn  Glu Ala Gly Gln Asp  Ile Cys Glu 
    7925                 7930                 7935             


Ala Leu  Val Ser Val Leu Glu  Pro Pro Tyr Phe Ile  Glu Pro Leu 
    7940                 7945                 7950             


Glu His  Val Glu Ala Val Ile  Gly Glu Pro Ala Thr  Leu Gln Cys 
    7955                 7960                 7965             


Lys Val  Asp Gly Thr Pro Glu  Ile Arg Ile Ser Trp  Tyr Lys Glu 
    7970                 7975                 7980             


His Thr  Lys Leu Arg Ser Ala  Pro Ala Tyr Lys Met  Gln Phe Lys 
    7985                 7990                 7995             


Asn Asn  Val Ala Ser Leu Val  Ile Asn Lys Val Asp  His Ser Asp 
    8000                 8005                 8010             


Val Gly  Glu Tyr Ser Cys Lys  Ala Asp Asn Ser Val  Gly Ala Val 
    8015                 8020                 8025             


Ala Ser  Ser Ala Val Leu Val  Ile Lys Ala Arg Lys  Leu Pro Pro 
    8030                 8035                 8040             


Phe Phe  Ala Arg Lys Leu Lys  Asp Val His Glu Thr  Leu Gly Phe 
    8045                 8050                 8055             


Pro Val  Ala Phe Glu Cys Arg  Ile Asn Gly Ser Glu  Pro Leu Gln 
    8060                 8065                 8070             


Val Ser  Trp Tyr Lys Asp Gly  Val Leu Leu Lys Asp  Asp Ala Asn 
    8075                 8080                 8085             


Leu Gln  Thr Ser Phe Val His  Asn Val Ala Thr Leu  Gln Ile Leu 
    8090                 8095                 8100             


Gln Thr  Asp Gln Ser His Ile  Gly Gln Tyr Asn Cys  Ser Ala Ser 
    8105                 8110                 8115             


Asn Pro  Leu Gly Thr Ala Ser  Ser Ser Ala Lys Leu  Ile Leu Ser 
    8120                 8125                 8130             


Glu His  Glu Val Pro Pro Phe  Phe Asp Leu Lys Pro  Val Ser Val 
    8135                 8140                 8145             


Asp Leu  Ala Leu Gly Glu Ser  Gly Thr Phe Lys Cys  His Val Thr 
    8150                 8155                 8160             


Gly Thr  Ala Pro Ile Lys Ile  Thr Trp Ala Lys Asp  Asn Arg Glu 
    8165                 8170                 8175             


Ile Arg  Pro Gly Gly Asn Tyr  Lys Met Thr Leu Val  Glu Asn Thr 
    8180                 8185                 8190             


Ala Thr  Leu Thr Val Leu Lys  Val Gly Lys Gly Asp  Ala Gly Gln 
    8195                 8200                 8205             


Tyr Thr  Cys Tyr Ala Ser Asn  Ile Ala Gly Lys Asp  Ser Cys Ser 
    8210                 8215                 8220             


Ala Gln  Leu Gly Val Gln Glu  Pro Pro Arg Phe Ile  Lys Lys Leu 
    8225                 8230                 8235             


Glu Pro  Ser Arg Ile Val Lys  Gln Asp Glu Phe Thr  Arg Tyr Glu 
    8240                 8245                 8250             


Cys Lys  Ile Gly Gly Ser Pro  Glu Ile Lys Val Leu  Trp Tyr Lys 
    8255                 8260                 8265             


Asp Glu  Thr Glu Ile Gln Glu  Ser Ser Lys Phe Arg  Met Ser Phe 
    8270                 8275                 8280             


Val Asp  Ser Val Ala Val Leu  Glu Met His Asn Leu  Ser Val Glu 
    8285                 8290                 8295             


Asp Ser  Gly Asp Tyr Thr Cys  Glu Ala His Asn Ala  Ala Gly Ser 
    8300                 8305                 8310             


Ala Ser  Ser Ser Thr Ser Leu  Lys Val Lys Glu Pro  Pro Ile Phe 
    8315                 8320                 8325             


Arg Lys  Lys Pro His Pro Ile  Glu Thr Leu Lys Gly  Ala Asp Val 
    8330                 8335                 8340             


His Leu  Glu Cys Glu Leu Gln  Gly Thr Pro Pro Phe  His Val Ser 
    8345                 8350                 8355             


Trp Tyr  Lys Asp Lys Arg Glu  Leu Arg Ser Gly Lys  Lys Tyr Lys 
    8360                 8365                 8370             


Ile Met  Ser Glu Asn Phe Leu  Thr Ser Ile His Ile  Leu Asn Val 
    8375                 8380                 8385             


Asp Ala  Ala Asp Ile Gly Glu  Tyr Gln Cys Lys Ala  Thr Asn Asp 
    8390                 8395                 8400             


Val Gly  Ser Asp Thr Cys Val  Gly Ser Ile Ala Leu  Lys Ala Pro 
    8405                 8410                 8415             


Pro Arg  Phe Val Lys Lys Leu  Ser Asp Ile Ser Thr  Val Val Gly 
    8420                 8425                 8430             


Lys Glu  Val Gln Leu Gln Thr  Thr Ile Glu Gly Ala  Glu Pro Ile 
    8435                 8440                 8445             


Ser Val  Val Trp Phe Lys Asp  Lys Gly Glu Ile Val  Arg Glu Ser 
    8450                 8455                 8460             


Asp Asn  Ile Trp Ile Ser Tyr  Ser Glu Asn Ile Ala  Thr Leu Gln 
    8465                 8470                 8475             


Phe Ser  Arg Val Glu Pro Ala  Asn Ala Gly Lys Tyr  Thr Cys Gln 
    8480                 8485                 8490             


Ile Lys  Asn Asp Ala Gly Met  Gln Glu Cys Phe Ala  Thr Leu Ser 
    8495                 8500                 8505             


Val Leu  Glu Pro Ala Thr Ile  Val Glu Lys Pro Glu  Ser Ile Lys 
    8510                 8515                 8520             


Val Thr  Thr Gly Asp Thr Cys  Thr Leu Glu Cys Thr  Val Ala Gly 
    8525                 8530                 8535             


Thr Pro  Glu Leu Ser Thr Lys  Trp Phe Lys Asp Gly  Lys Glu Leu 
    8540                 8545                 8550             


Thr Ser  Asp Asn Lys Tyr Lys  Ile Ser Phe Phe Asn  Lys Val Ser 
    8555                 8560                 8565             


Gly Leu  Lys Ile Ile Asn Val  Ala Pro Ser Asp Ser  Gly Val Tyr 
    8570                 8575                 8580             


Ser Phe  Glu Val Gln Asn Pro  Val Gly Lys Asp Ser  Cys Thr Ala 
    8585                 8590                 8595             


Ser Leu  Gln Val Ser Asp Arg  Thr Val Pro Pro Ser  Phe Thr Arg 
    8600                 8605                 8610             


Lys Leu  Lys Glu Thr Asn Gly  Leu Ser Gly Ser Ser  Val Val Met 
    8615                 8620                 8625             


Glu Cys  Lys Val Tyr Gly Ser  Pro Pro Ile Ser Val  Ser Trp Phe 
    8630                 8635                 8640             


His Glu  Gly Asn Glu Ile Ser  Ser Gly Arg Lys Tyr  Gln Thr Thr 
    8645                 8650                 8655             


Leu Thr  Asp Asn Thr Cys Ala  Leu Thr Val Asn Met  Leu Glu Glu 
    8660                 8665                 8670             


Ser Asp  Ser Gly Asp Tyr Thr  Cys Ile Ala Thr Asn  Met Ala Gly 
    8675                 8680                 8685             


Ser Asp  Glu Cys Ser Ala Pro  Leu Thr Val Arg Glu  Pro Pro Ser 
    8690                 8695                 8700             


Phe Val  Gln Lys Pro Asp Pro  Met Asp Val Leu Thr  Gly Thr Asn 
    8705                 8710                 8715             


Val Thr  Phe Thr Ser Ile Val  Lys Gly Thr Pro Pro  Phe Ser Val 
    8720                 8725                 8730             


Ser Trp  Phe Lys Gly Ser Ser  Glu Leu Val Pro Gly  Asp Arg Cys 
    8735                 8740                 8745             


Asn Val  Ser Leu Glu Asp Ser  Val Ala Glu Leu Glu  Leu Phe Asp 
    8750                 8755                 8760             


Val Asp  Thr Ser Gln Ser Gly  Glu Tyr Thr Cys Ile  Val Ser Asn 
    8765                 8770                 8775             


Glu Ala  Gly Lys Ala Ser Cys  Thr Thr His Leu Tyr  Ile Lys Ala 
    8780                 8785                 8790             


Pro Ala  Lys Phe Val Lys Arg  Leu Asn Asp Tyr Ser  Ile Glu Lys 
    8795                 8800                 8805             


Gly Lys  Pro Leu Ile Leu Glu  Gly Thr Phe Thr Gly  Thr Pro Pro 
    8810                 8815                 8820             


Ile Ser  Val Thr Trp Lys Lys  Asn Gly Ile Asn Val  Thr Pro Ser 
    8825                 8830                 8835             


Gln Arg  Cys Asn Ile Thr Thr  Thr Glu Lys Ser Ala  Ile Leu Glu 
    8840                 8845                 8850             


Ile Pro  Ser Ser Thr Val Glu  Asp Ala Gly Gln Tyr  Asn Cys Tyr 
    8855                 8860                 8865             


Ile Glu  Asn Ala Ser Gly Lys  Asp Ser Cys Ser Ala  Gln Ile Leu 
    8870                 8875                 8880             


Ile Leu  Glu Pro Pro Tyr Phe  Val Lys Gln Leu Glu  Pro Val Lys 
    8885                 8890                 8895             


Val Ser  Val Gly Asp Ser Ala  Ser Leu Gln Cys Gln  Leu Ala Gly 
    8900                 8905                 8910             


Thr Pro  Glu Ile Gly Val Ser  Trp Tyr Lys Gly Asp  Thr Lys Leu 
    8915                 8920                 8925             


Arg Pro  Thr Thr Thr Tyr Lys  Met His Phe Arg Asn  Asn Val Ala 
    8930                 8935                 8940             


Thr Leu  Val Phe Asn Gln Val  Asp Ile Asn Asp Ser  Gly Glu Tyr 
    8945                 8950                 8955             


Ile Cys  Lys Ala Glu Asn Ser  Val Gly Glu Val Ser  Ala Ser Thr 
    8960                 8965                 8970             


Phe Leu  Thr Val Gln Glu Gln  Lys Leu Pro Pro Ser  Phe Ser Arg 
    8975                 8980                 8985             


Gln Leu  Arg Asp Val Gln Glu  Thr Val Gly Leu Pro  Val Val Phe 
    8990                 8995                 9000             


Asp Cys  Ala Ile Ser Gly Ser  Glu Pro Ile Ser Val  Ser Trp Tyr 
    9005                 9010                 9015             


Lys Asp  Gly Lys Pro Leu Lys  Asp Ser Pro Asn Val  Gln Thr Ser 
    9020                 9025                 9030             


Phe Leu  Asp Asn Thr Ala Thr  Leu Asn Ile Phe Lys  Thr Asp Arg 
    9035                 9040                 9045             


Ser Leu  Ala Gly Gln Tyr Ser  Cys Thr Ala Thr Asn  Pro Ile Gly 
    9050                 9055                 9060             


Ser Ala  Ser Ser Ser Ala Arg  Leu Ile Leu Thr Glu  Gly Lys Asn 
    9065                 9070                 9075             


Pro Pro  Phe Phe Asp Ile Arg  Leu Ala Pro Val Asp  Ala Val Val 
    9080                 9085                 9090             


Gly Glu  Ser Ala Asp Phe Glu  Cys His Val Thr Gly  Thr Gln Pro 
    9095                 9100                 9105             


Ile Lys  Val Ser Trp Ala Lys  Asp Ser Arg Glu Ile  Arg Ser Gly 
    9110                 9115                 9120             


Gly Lys  Tyr Gln Ile Ser Tyr  Leu Glu Asn Ser Ala  His Leu Thr 
    9125                 9130                 9135             


Val Leu  Lys Val Asp Lys Gly  Asp Ser Gly Gln Tyr  Thr Cys Tyr 
    9140                 9145                 9150             


Ala Val  Asn Glu Val Gly Lys  Asp Ser Cys Thr Ala  Gln Leu Asn 
    9155                 9160                 9165             


Ile Lys  Glu Arg Leu Ile Pro  Pro Ser Phe Thr Lys  Arg Leu Ser 
    9170                 9175                 9180             


Glu Thr  Val Glu Glu Thr Glu  Gly Asn Ser Phe Lys  Leu Glu Gly 
    9185                 9190                 9195             


Arg Val  Ala Gly Ser Gln Pro  Ile Thr Val Ala Trp  Tyr Lys Asn 
    9200                 9205                 9210             


Asn Ile  Glu Ile Gln Pro Thr  Ser Asn Cys Glu Ile  Thr Phe Lys 
    9215                 9220                 9225             


Asn Asn  Thr Leu Val Leu Gln  Val Arg Lys Ala Gly  Met Asn Asp 
    9230                 9235                 9240             


Ala Gly  Leu Tyr Thr Cys Lys  Val Ser Asn Asp Ala  Gly Ser Ala 
    9245                 9250                 9255             


Leu Cys  Thr Ser Ser Ile Val  Ile Lys Glu Pro Lys  Lys Pro Pro 
    9260                 9265                 9270             


Val Phe  Asp Gln His Leu Thr  Pro Val Thr Val Ser  Glu Gly Glu 
    9275                 9280                 9285             


Tyr Val  Gln Leu Ser Cys His  Val Gln Gly Ser Glu  Pro Ile Arg 
    9290                 9295                 9300             


Ile Gln  Trp Leu Lys Ala Gly  Arg Glu Ile Lys Pro  Ser Asp Arg 
    9305                 9310                 9315             


Cys Ser  Phe Ser Phe Ala Ser  Gly Thr Ala Val Leu  Glu Leu Arg 
    9320                 9325                 9330             


Asp Val  Ala Lys Ala Asp Ser  Gly Asp Tyr Val Cys  Lys Ala Ser 
    9335                 9340                 9345             


Asn Val  Ala Gly Ser Asp Thr  Thr Lys Ser Lys Val  Thr Ile Lys 
    9350                 9355                 9360             


Asp Lys  Pro Ala Val Ala Pro  Ala Thr Lys Lys Ala  Ala Val Asp 
    9365                 9370                 9375             


Gly Arg  Leu Phe Phe Val Ser  Glu Pro Gln Ser Ile  Arg Val Val 
    9380                 9385                 9390             


Glu Lys  Thr Thr Ala Thr Phe  Ile Ala Lys Val Gly  Gly Asp Pro 
    9395                 9400                 9405             


Ile Pro  Asn Val Lys Trp Thr  Lys Gly Lys Trp Arg  Gln Leu Asn 
    9410                 9415                 9420             


Gln Gly  Gly Arg Val Phe Ile  His Gln Lys Gly Asp  Glu Ala Lys 
    9425                 9430                 9435             


Leu Glu  Ile Arg Asp Thr Thr  Lys Thr Asp Ser Gly  Leu Tyr Arg 
    9440                 9445                 9450             


Cys Val  Ala Phe Asn Glu His  Gly Glu Ile Glu Ser  Asn Val Asn 
    9455                 9460                 9465             


Leu Gln  Val Asp Glu Arg Lys  Lys Gln Glu Lys Ile  Glu Gly Asp 
    9470                 9475                 9480             


Leu Arg  Ala Met Leu Lys Lys  Thr Pro Ile Leu Lys  Lys Gly Ala 
    9485                 9490                 9495             


Gly Glu  Glu Glu Glu Ile Asp  Ile Met Glu Leu Leu  Lys Asn Val 
    9500                 9505                 9510             


Asp Pro  Lys Glu Tyr Glu Lys  Tyr Ala Arg Met Tyr  Gly Ile Thr 
    9515                 9520                 9525             


Asp Phe  Arg Gly Leu Leu Gln  Ala Phe Glu Leu Leu  Lys Gln Ser 
    9530                 9535                 9540             


Gln Glu  Glu Glu Thr His Arg  Leu Glu Ile Glu Glu  Ile Glu Arg 
    9545                 9550                 9555             


Ser Glu  Arg Asp Glu Lys Glu  Phe Glu Glu Leu Val  Ser Phe Ile 
    9560                 9565                 9570             


Gln Gln  Arg Leu Ser Gln Thr  Glu Pro Val Thr Leu  Ile Lys Asp 
    9575                 9580                 9585             


Ile Glu  Asn Gln Thr Val Leu  Lys Asp Asn Asp Ala  Val Phe Glu 
    9590                 9595                 9600             


Ile Asp  Ile Lys Ile Asn Tyr  Pro Glu Ile Lys Leu  Ser Trp Tyr 
    9605                 9610                 9615             


Lys Gly  Thr Glu Lys Leu Glu  Pro Ser Asp Lys Phe  Glu Ile Ser 
    9620                 9625                 9630             


Ile Asp  Gly Asp Arg His Thr  Leu Arg Val Lys Asn  Cys Gln Leu 
    9635                 9640                 9645             


Lys Asp  Gln Gly Asn Tyr Arg  Leu Val Cys Gly Pro  His Ile Ala 
    9650                 9655                 9660             


Ser Ala  Lys Leu Thr Val Ile  Glu Pro Ala Trp Glu  Arg His Leu 
    9665                 9670                 9675             


Gln Asp  Val Thr Leu Lys Glu  Gly Gln Thr Cys Thr  Met Thr Cys 
    9680                 9685                 9690             


Gln Phe  Ser Val Pro Asn Val  Lys Ser Glu Trp Phe  Arg Asn Gly 
    9695                 9700                 9705             


Arg Ile  Leu Lys Pro Gln Gly  Arg His Lys Thr Glu  Val Glu His 
    9710                 9715                 9720             


Lys Val  His Lys Leu Thr Ile  Ala Asp Val Arg Ala  Glu Asp Gln 
    9725                 9730                 9735             


Gly Gln  Tyr Thr Cys Lys Tyr  Glu Asp Leu Glu Thr  Ser Ala Glu 
    9740                 9745                 9750             


Leu Arg  Ile Glu Ala Glu Pro  Ile Gln Phe Thr Lys  Arg Ile Gln 
    9755                 9760                 9765             


Asn Ile  Val Val Ser Glu His  Gln Ser Ala Thr Phe  Glu Cys Glu 
    9770                 9775                 9780             


Val Ser  Phe Asp Asp Ala Ile  Val Thr Trp Tyr Lys  Gly Pro Thr 
    9785                 9790                 9795             


Glu Leu  Thr Glu Ser Gln Lys  Tyr Asn Phe Arg Asn  Asp Gly Arg 
    9800                 9805                 9810             


Cys His  Tyr Met Thr Ile His  Asn Val Thr Pro Asp  Asp Glu Gly 
    9815                 9820                 9825             


Val Tyr  Ser Val Ile Ala Arg  Leu Glu Pro Arg Gly  Glu Ala Arg 
    9830                 9835                 9840             


Ser Thr  Ala Glu Leu Tyr Leu  Thr Thr Lys Glu Ile  Lys Leu Glu 
    9845                 9850                 9855             


Leu Lys  Pro Pro Asp Ile Pro  Asp Ser Arg Val Pro  Ile Pro Thr 
    9860                 9865                 9870             


Met Pro  Ile Arg Ala Val Pro  Pro Glu Glu Ile Pro  Pro Val Val 
    9875                 9880                 9885             


Ala Pro  Pro Ile Pro Leu Leu  Leu Pro Thr Pro Glu  Glu Lys Lys 
    9890                 9895                 9900             


Pro Pro  Pro Lys Arg Ile Glu  Val Thr Lys Lys Ala  Val Lys Lys 
    9905                 9910                 9915             


Asp Ala  Lys Lys Val Val Ala  Lys Pro Lys Glu Met  Thr Pro Arg 
    9920                 9925                 9930             


Glu Glu  Ile Val Lys Lys Pro  Pro Pro Pro Thr Thr  Leu Ile Pro 
    9935                 9940                 9945             


Ala Lys  Ala Pro Glu Ile Ile  Asp Val Ser Ser Lys  Ala Glu Glu 
    9950                 9955                 9960             


Val Lys  Ile Met Thr Ile Thr  Arg Lys Lys Glu Val  Gln Lys Glu 
    9965                 9970                 9975             


Lys Glu  Ala Val Tyr Glu Lys  Lys Gln Ala Val His  Lys Glu Lys 
    9980                 9985                 9990             


Arg Val  Phe Ile Glu Ser Phe   Glu Glu Pro Tyr Asp   Glu Leu Glu 
    9995                 10000                 10005             


Val Glu   Pro Tyr Thr Glu Pro   Phe Glu Gln Pro Tyr   Tyr Glu Glu 
    10010                 10015                 10020             


Pro Asp   Glu Asp Tyr Glu Glu   Ile Lys Val Glu Ala   Lys Lys Glu 
    10025                 10030                 10035             


Val His   Glu Glu Trp Glu Glu   Asp Phe Glu Glu Gly   Gln Glu Tyr 
    10040                 10045                 10050             


Tyr Glu   Arg Glu Glu Gly Tyr   Asp Glu Gly Glu Glu   Glu Trp Glu 
    10055                 10060                 10065             


Glu Ala   Tyr Gln Glu Arg Glu   Val Ile Gln Val Gln   Lys Glu Val 
    10070                 10075                 10080             


Tyr Glu   Glu Ser His Glu Arg   Lys Val Pro Ala Lys   Val Pro Glu 
    10085                 10090                 10095             


Lys Lys   Ala Pro Pro Pro Pro   Lys Val Ile Lys Lys   Pro Val Ile 
    10100                 10105                 10110             


Glu Lys   Ile Glu Lys Thr Ser   Arg Arg Met Glu Glu   Glu Lys Val 
    10115                 10120                 10125             


Gln Val   Thr Lys Val Pro Glu   Val Ser Lys Lys Ile   Val Pro Gln 
    10130                 10135                 10140             


Lys Pro   Ser Arg Thr Pro Val   Gln Glu Glu Val Ile   Glu Val Lys 
    10145                 10150                 10155             


Val Pro   Ala Val His Thr Lys   Lys Met Val Ile Ser   Glu Glu Lys 
    10160                 10165                 10170             


Met Phe   Phe Ala Ser His Thr   Glu Glu Glu Val Ser   Val Thr Val 
    10175                 10180                 10185             


Pro Glu   Val Gln Lys Glu Ile   Val Thr Glu Glu Lys   Ile His Val 
    10190                 10195                 10200             


Ala Ile   Ser Lys Arg Val Glu   Pro Pro Pro Lys Val   Pro Glu Leu 
    10205                 10210                 10215             


Pro Glu   Lys Pro Ala Pro Glu   Glu Val Ala Pro Val   Pro Ile Pro 
    10220                 10225                 10230             


Lys Lys   Val Glu Pro Pro Ala   Pro Lys Val Pro Glu   Val Pro Lys 
    10235                 10240                 10245             


Lys Pro   Val Pro Glu Glu Lys   Lys Pro Val Pro Val   Pro Lys Lys 
    10250                 10255                 10260             


Glu Pro   Ala Ala Pro Pro Lys   Val Pro Glu Val Pro   Lys Lys Pro 
    10265                 10270                 10275             


Val Pro   Glu Glu Lys Ile Pro   Val Pro Val Ala Lys   Lys Lys Glu 
    10280                 10285                 10290             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Gln Lys Gly   Val Val Thr 
    10295                 10300                 10305             


Glu Glu   Lys Ile Thr Ile Val   Thr Gln Arg Glu Glu   Ser Pro Pro 
    10310                 10315                 10320             


Pro Ala   Val Pro Glu Ile Pro   Lys Lys Lys Val Pro   Glu Glu Arg 
    10325                 10330                 10335             


Lys Pro   Val Pro Arg Lys Glu   Glu Glu Val Pro Pro   Pro Pro Lys 
    10340                 10345                 10350             


Val Pro   Ala Leu Pro Lys Lys   Pro Val Pro Glu Glu   Lys Val Ala 
    10355                 10360                 10365             


Val Pro   Val Pro Val Ala Lys   Lys Ala Pro Pro Pro   Arg Ala Glu 
    10370                 10375                 10380             


Val Ser   Lys Lys Thr Val Val   Glu Glu Lys Arg Phe   Val Ala Glu 
    10385                 10390                 10395             


Glu Lys   Leu Ser Phe Ala Val   Pro Gln Arg Val Glu   Val Thr Arg 
    10400                 10405                 10410             


His Glu   Val Ser Ala Glu Glu   Glu Trp Ser Tyr Ser   Glu Glu Glu 
    10415                 10420                 10425             


Glu Gly   Val Ser Ile Ser Val   Tyr Arg Glu Glu Glu   Arg Glu Glu 
    10430                 10435                 10440             


Glu Glu   Glu Ala Glu Val Thr   Glu Tyr Glu Val Met   Glu Glu Pro 
    10445                 10450                 10455             


Glu Glu   Tyr Val Val Glu Glu   Lys Leu His Ile Ile   Ser Lys Arg 
    10460                 10465                 10470             


Val Glu   Ala Glu Pro Ala Glu   Val Thr Glu Arg Gln   Glu Lys Lys 
    10475                 10480                 10485             


Ile Val   Leu Lys Pro Lys Ile   Pro Ala Lys Ile Glu   Glu Pro Pro 
    10490                 10495                 10500             


Pro Ala   Lys Val Pro Glu Ala   Pro Lys Lys Ile Val   Pro Glu Lys 
    10505                 10510                 10515             


Lys Val   Pro Ala Pro Val Pro   Lys Lys Glu Lys Val   Pro Pro Pro 
    10520                 10525                 10530             


Lys Val   Pro Glu Glu Pro Lys   Lys Pro Val Pro Glu   Lys Lys Val 
    10535                 10540                 10545             


Pro Pro   Lys Val Ile Lys Met   Glu Glu Pro Leu Pro   Ala Lys Val 
    10550                 10555                 10560             


Thr Glu   Arg His Met Gln Ile   Thr Gln Glu Glu Lys   Val Leu Val 
    10565                 10570                 10575             


Ala Val   Thr Lys Lys Glu Ala   Pro Pro Lys Ala Arg   Val Pro Glu 
    10580                 10585                 10590             


Glu Pro   Lys Arg Ala Val Pro   Glu Glu Lys Val Leu   Lys Leu Lys 
    10595                 10600                 10605             


Pro Lys   Arg Glu Glu Glu Pro   Pro Ala Lys Val Thr   Glu Phe Arg 
    10610                 10615                 10620             


Lys Arg   Val Val Lys Glu Glu   Lys Val Ser Ile Glu   Ala Pro Lys 
    10625                 10630                 10635             


Arg Glu   Pro Gln Pro Ile Lys   Glu Val Thr Ile Met   Glu Glu Lys 
    10640                 10645                 10650             


Glu Arg   Ala Tyr Thr Leu Glu   Glu Glu Ala Val Ser   Val Gln Arg 
    10655                 10660                 10665             


Glu Glu   Glu Tyr Glu Glu Tyr   Glu Glu Tyr Asp Tyr   Lys Glu Phe 
    10670                 10675                 10680             


Glu Glu   Tyr Glu Pro Thr Glu   Glu Tyr Asp Gln Tyr   Glu Glu Tyr 
    10685                 10690                 10695             


Glu Glu   Arg Glu Tyr Glu Arg   Tyr Glu Glu His Glu   Glu Tyr Ile 
    10700                 10705                 10710             


Thr Glu   Pro Glu Lys Pro Ile   Pro Val Lys Pro Val   Pro Glu Glu 
    10715                 10720                 10725             


Pro Val   Pro Thr Lys Pro Lys   Ala Pro Pro Ala Lys   Val Leu Lys 
    10730                 10735                 10740             


Lys Ala   Val Pro Glu Glu Lys   Val Pro Val Pro Ile   Pro Lys Lys 
    10745                 10750                 10755             


Leu Lys   Pro Pro Pro Pro Lys   Val Pro Glu Glu Pro   Lys Lys Val 
    10760                 10765                 10770             


Phe Glu   Glu Lys Ile Arg Ile   Ser Ile Thr Lys Arg   Glu Lys Glu 
    10775                 10780                 10785             


Gln Val   Thr Glu Pro Ala Ala   Lys Val Pro Met Lys   Pro Lys Arg 
    10790                 10795                 10800             


Val Val   Ala Glu Glu Lys Val   Pro Val Pro Arg Lys   Glu Val Ala 
    10805                 10810                 10815             


Pro Pro   Val Arg Val Pro Glu   Val Pro Lys Glu Leu   Glu Pro Glu 
    10820                 10825                 10830             


Glu Val   Ala Phe Glu Glu Glu   Val Val Thr His Val   Glu Glu Tyr 
    10835                 10840                 10845             


Leu Val   Glu Glu Glu Glu Glu   Tyr Ile His Glu Glu   Glu Glu Phe 
    10850                 10855                 10860             


Ile Thr   Glu Glu Glu Val Val   Pro Val Ile Pro Val   Lys Val Pro 
    10865                 10870                 10875             


Glu Val   Pro Arg Lys Pro Val   Pro Glu Glu Lys Lys   Pro Val Pro 
    10880                 10885                 10890             


Val Pro   Lys Lys Lys Glu Ala   Pro Pro Ala Lys Val   Pro Glu Val 
    10895                 10900                 10905             


Pro Lys   Lys Pro Glu Glu Lys   Val Pro Val Leu Ile   Pro Lys Lys 
    10910                 10915                 10920             


Glu Lys   Pro Pro Pro Ala Lys   Val Pro Glu Val Pro   Lys Lys Pro 
    10925                 10930                 10935             


Val Pro   Glu Glu Lys Val Pro   Val Pro Val Pro Lys   Lys Val Glu 
    10940                 10945                 10950             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Pro Lys Lys   Pro Val Pro 
    10955                 10960                 10965             


Glu Lys   Lys Val Pro Val Pro   Ala Pro Lys Lys Val   Glu Ala Pro 
    10970                 10975                 10980             


Pro Ala   Lys Val Pro Glu Val   Pro Lys Lys Leu Ile   Pro Glu Glu 
    10985                 10990                 10995             


Lys Lys   Pro Thr Pro Val Pro   Lys Lys Val Glu Ala   Pro Pro Pro 
    11000                 11005                 11010             


Lys Val   Pro Lys Lys Arg Glu   Pro Val Pro Val Pro   Val Ala Leu 
    11015                 11020                 11025             


Pro Gln   Glu Glu Glu Val Leu   Phe Glu Glu Glu Ile   Val Pro Glu 
    11030                 11035                 11040             


Glu Glu   Val Leu Pro Glu Glu   Glu Glu Val Leu Pro   Glu Glu Glu 
    11045                 11050                 11055             


Glu Val   Leu Pro Glu Glu Glu   Glu Val Leu Pro Glu   Glu Glu Glu 
    11060                 11065                 11070             


Ile Pro   Pro Glu Glu Glu Glu   Val Pro Pro Glu Glu   Glu Tyr Val 
    11075                 11080                 11085             


Pro Glu   Glu Glu Glu Phe Val   Pro Glu Glu Glu Val   Leu Pro Glu 
    11090                 11095                 11100             


Val Lys   Pro Lys Val Pro Val   Pro Ala Pro Val Pro   Glu Ile Lys 
    11105                 11110                 11115             


Lys Lys   Val Thr Glu Lys Lys   Val Val Ile Pro Lys   Lys Glu Glu 
    11120                 11125                 11130             


Ala Pro   Pro Ala Lys Val Pro   Glu Val Pro Lys Lys   Val Glu Glu 
    11135                 11140                 11145             


Lys Arg   Ile Ile Leu Pro Lys   Glu Glu Glu Val Leu   Pro Val Glu 
    11150                 11155                 11160             


Val Thr   Glu Glu Pro Glu Glu   Glu Pro Ile Ser Glu   Glu Glu Ile 
    11165                 11170                 11175             


Pro Glu   Glu Pro Pro Ser Ile   Glu Glu Val Glu Glu   Val Ala Pro 
    11180                 11185                 11190             


Pro Arg   Val Pro Glu Val Ile   Lys Lys Ala Val Pro   Glu Ala Pro 
    11195                 11200                 11205             


Thr Pro   Val Pro Lys Lys Val   Glu Ala Pro Pro Ala   Lys Val Ser 
    11210                 11215                 11220             


Lys Lys   Ile Pro Glu Glu Lys   Val Pro Val Pro Val   Gln Lys Lys 
    11225                 11230                 11235             


Glu Ala   Pro Pro Ala Lys Val   Pro Glu Val Pro Lys   Lys Val Pro 
    11240                 11245                 11250             


Glu Lys   Lys Val Leu Val Pro   Lys Lys Glu Ala Val   Pro Pro Ala 
    11255                 11260                 11265             


Lys Gly   Arg Thr Val Leu Glu   Glu Lys Val Ser Val   Ala Phe Arg 
    11270                 11275                 11280             


Gln Glu   Val Val Val Lys Glu   Arg Leu Glu Leu Glu   Val Val Glu 
    11285                 11290                 11295             


Ala Glu   Val Glu Glu Ile Pro   Glu Glu Glu Glu Phe   His Glu Val 
    11300                 11305                 11310             


Glu Glu   Tyr Phe Glu Glu Gly   Glu Phe His Glu Val   Glu Glu Phe 
    11315                 11320                 11325             


Ile Lys   Leu Glu Gln His Arg   Val Glu Glu Glu His   Arg Val Glu 
    11330                 11335                 11340             


Lys Val   His Arg Val Ile Glu   Val Phe Glu Ala Glu   Glu Val Glu 
    11345                 11350                 11355             


Val Phe   Glu Lys Pro Lys Ala   Pro Pro Lys Gly Pro   Glu Ile Ser 
    11360                 11365                 11370             


Glu Lys   Ile Ile Pro Pro Lys   Lys Pro Pro Thr Lys   Val Val Pro 
    11375                 11380                 11385             


Arg Lys   Glu Pro Pro Ala Lys   Val Pro Glu Val Pro   Lys Lys Ile 
    11390                 11395                 11400             


Val Val   Glu Glu Lys Val Arg   Val Pro Glu Glu Pro   Arg Val Pro 
    11405                 11410                 11415             


Pro Thr   Lys Val Pro Glu Val   Leu Pro Pro Lys Glu   Val Val Pro 
    11420                 11425                 11430             


Glu Lys   Lys Val Pro Val Pro   Pro Ala Lys Lys Pro   Glu Ala Pro 
    11435                 11440                 11445             


Pro Pro   Lys Val Pro Glu Ala   Pro Lys Glu Val Val   Pro Glu Lys 
    11450                 11455                 11460             


Lys Val   Pro Val Pro Pro Pro   Lys Lys Pro Glu Val   Pro Pro Thr 
    11465                 11470                 11475             


Lys Val   Pro Glu Val Pro Lys   Ala Ala Val Pro Glu   Lys Lys Val 
    11480                 11485                 11490             


Pro Glu   Ala Ile Pro Pro Lys   Pro Glu Ser Pro Pro   Pro Glu Val 
    11495                 11500                 11505             


Pro Glu   Ala Pro Lys Glu Val   Val Pro Glu Lys Lys   Val Pro Ala 
    11510                 11515                 11520             


Ala Pro   Pro Lys Lys Pro Glu   Val Thr Pro Val Lys   Val Pro Glu 
    11525                 11530                 11535             


Ala Pro   Lys Glu Val Val Pro   Glu Lys Lys Val Pro   Val Pro Pro 
    11540                 11545                 11550             


Pro Lys   Lys Pro Glu Val Pro   Pro Thr Lys Val Pro   Glu Val Pro 
    11555                 11560                 11565             


Lys Val   Ala Val Pro Glu Lys   Lys Val Pro Glu Ala   Ile Pro Pro 
    11570                 11575                 11580             


Lys Pro   Glu Ser Pro Pro Pro   Glu Val Phe Glu Glu   Pro Glu Glu 
    11585                 11590                 11595             


Val Ala   Leu Glu Glu Pro Pro   Ala Glu Val Val Glu   Glu Pro Glu 
    11600                 11605                 11610             


Pro Ala   Ala Pro Pro Gln Val   Thr Val Pro Pro Lys   Lys Pro Val 
    11615                 11620                 11625             


Pro Glu   Lys Lys Ala Pro Ala   Val Val Ala Lys Lys   Pro Glu Leu 
    11630                 11635                 11640             


Pro Pro   Val Lys Val Pro Glu   Val Pro Lys Glu Val   Val Pro Glu 
    11645                 11650                 11655             


Lys Lys   Val Pro Leu Val Val   Pro Lys Lys Pro Glu   Ala Pro Pro 
    11660                 11665                 11670             


Ala Lys   Val Pro Glu Val Pro   Lys Glu Val Val Pro   Glu Lys Lys 
    11675                 11680                 11685             


Val Ala   Val Pro Lys Lys Pro   Glu Val Pro Pro Ala   Lys Val Pro 
    11690                 11695                 11700             


Glu Val   Pro Lys Lys Pro Val   Leu Glu Glu Lys Pro   Ala Val Pro 
    11705                 11710                 11715             


Val Pro   Glu Arg Ala Glu Ser   Pro Pro Pro Glu Val   Tyr Glu Glu 
    11720                 11725                 11730             


Pro Glu   Glu Ile Ala Pro Glu   Glu Glu Ile Ala Pro   Glu Glu Glu 
    11735                 11740                 11745             


Lys Pro   Val Pro Val Ala Glu   Glu Glu Glu Pro Glu   Val Pro Pro 
    11750                 11755                 11760             


Pro Ala   Val Pro Glu Glu Pro   Lys Lys Ile Ile Pro   Glu Lys Lys 
    11765                 11770                 11775             


Val Pro   Val Ile Lys Lys Pro   Glu Ala Pro Pro Pro   Lys Glu Pro 
    11780                 11785                 11790             


Glu Pro   Glu Lys Val Ile Glu   Lys Pro Lys Leu Lys   Pro Arg Pro 
    11795                 11800                 11805             


Pro Pro   Pro Pro Pro Ala Pro   Pro Lys Glu Asp Val   Lys Glu Lys 
    11810                 11815                 11820             


Ile Phe   Gln Leu Lys Ala Ile   Pro Lys Lys Lys Val   Pro Glu Lys 
    11825                 11830                 11835             


Pro Gln   Val Pro Glu Lys Val   Glu Leu Thr Pro Leu   Lys Val Pro 
    11840                 11845                 11850             


Gly Gly   Glu Lys Lys Val Arg   Lys Leu Leu Pro Glu   Arg Lys Pro 
    11855                 11860                 11865             


Glu Pro   Lys Glu Glu Val Val   Leu Lys Ser Val Leu   Arg Lys Arg 
    11870                 11875                 11880             


Pro Glu   Glu Glu Glu Pro Lys   Val Glu Pro Lys Lys   Leu Glu Lys 
    11885                 11890                 11895             


Val Lys   Lys Pro Ala Val Pro   Glu Pro Pro Pro Pro   Lys Pro Val 
    11900                 11905                 11910             


Glu Glu   Val Glu Val Pro Thr   Val Thr Lys Arg Glu   Arg Lys Ile 
    11915                 11920                 11925             


Pro Glu   Pro Thr Lys Val Pro   Glu Ile Lys Pro Ala   Ile Pro Leu 
    11930                 11935                 11940             


Pro Ala   Pro Glu Pro Lys Pro   Lys Pro Glu Ala Glu   Val Lys Thr 
    11945                 11950                 11955             


Ile Lys   Pro Pro Pro Val Glu   Pro Glu Pro Thr Pro   Ile Ala Ala 
    11960                 11965                 11970             


Pro Val   Thr Val Pro Val Val   Gly Lys Lys Ala Glu   Ala Lys Ala 
    11975                 11980                 11985             


Pro Lys   Glu Glu Ala Ala Lys   Pro Lys Gly Pro Ile   Lys Gly Val 
    11990                 11995                 12000             


Pro Lys   Lys Thr Pro Ser Pro   Ile Glu Ala Glu Arg   Arg Lys Leu 
    12005                 12010                 12015             


Arg Pro   Gly Ser Gly Gly Glu   Lys Pro Pro Asp Glu   Ala Pro Phe 
    12020                 12025                 12030             


Thr Tyr   Gln Leu Lys Ala Val   Pro Leu Lys Phe Val   Lys Glu Ile 
    12035                 12040                 12045             


Lys Asp   Ile Ile Leu Thr Glu   Ser Glu Phe Val Gly   Ser Ser Ala 
    12050                 12055                 12060             


Ile Phe   Glu Cys Leu Val Ser   Pro Ser Thr Ala Ile   Thr Thr Trp 
    12065                 12070                 12075             


Met Lys   Asp Gly Ser Asn Ile   Arg Glu Ser Pro Lys   His Arg Phe 
    12080                 12085                 12090             


Ile Ala   Asp Gly Lys Asp Arg   Lys Leu His Ile Ile   Asp Val Gln 
    12095                 12100                 12105             


Leu Ser   Asp Ala Gly Glu Tyr   Thr Cys Val Leu Arg   Leu Gly Asn 
    12110                 12115                 12120             


Lys Glu   Lys Thr Ser Thr Ala   Lys Leu Val Val Glu   Glu Leu Pro 
    12125                 12130                 12135             


Val Arg   Phe Val Lys Thr Leu   Glu Glu Glu Val Thr   Val Val Lys 
    12140                 12145                 12150             


Gly Gln   Pro Leu Tyr Leu Ser   Cys Glu Leu Asn Lys   Glu Arg Asp 
    12155                 12160                 12165             


Val Val   Trp Arg Lys Asp Gly   Lys Ile Val Val Glu   Lys Pro Gly 
    12170                 12175                 12180             


Arg Ile   Val Pro Gly Val Ile   Gly Leu Met Arg Ala   Leu Thr Ile 
    12185                 12190                 12195             


Asn Asp   Ala Asp Asp Thr Asp   Ala Gly Thr Tyr Thr   Val Thr Val 
    12200                 12205                 12210             


Glu Asn   Ala Asn Asn Leu Glu   Cys Ser Ser Cys Val   Lys Val Val 
    12215                 12220                 12225             


Glu Val   Ile Arg Asp Trp Leu   Val Lys Pro Ile Arg   Asp Gln His 
    12230                 12235                 12240             


Val Lys   Pro Lys Gly Thr Ala   Ile Phe Ala Cys Asp   Ile Ala Lys 
    12245                 12250                 12255             


Asp Thr   Pro Asn Ile Lys Trp   Phe Lys Gly Tyr Asp   Glu Ile Pro 
    12260                 12265                 12270             


Ala Glu   Pro Asn Asp Lys Thr   Glu Ile Leu Arg Asp   Gly Asn His 
    12275                 12280                 12285             


Leu Tyr   Leu Lys Ile Lys Asn   Ala Met Pro Glu Asp   Ile Ala Glu 
    12290                 12295                 12300             


Tyr Ala   Val Glu Ile Glu Gly   Lys Arg Tyr Pro Ala   Lys Leu Thr 
    12305                 12310                 12315             


Leu Gly   Glu Arg Glu Val Glu   Leu Leu Lys Pro Ile   Glu Asp Val 
    12320                 12325                 12330             


Thr Ile   Tyr Glu Lys Glu Ser   Ala Ser Phe Asp Ala   Glu Ile Ser 
    12335                 12340                 12345             


Glu Ala   Asp Ile Pro Gly Gln   Trp Lys Leu Lys Gly   Glu Leu Leu 
    12350                 12355                 12360             


Arg Pro   Ser Pro Thr Cys Glu   Ile Lys Ala Glu Gly   Gly Lys Arg 
    12365                 12370                 12375             


Phe Leu   Thr Leu His Lys Val   Lys Leu Asp Gln Ala   Gly Glu Val 
    12380                 12385                 12390             


Leu Tyr   Gln Ala Leu Asn Ala   Ile Thr Thr Ala Ile   Leu Thr Val 
    12395                 12400                 12405             


Lys Glu   Ile Glu Leu Asp Phe   Ala Val Pro Leu Lys   Asp Val Thr 
    12410                 12415                 12420             


Val Pro   Glu Arg Arg Gln Ala   Arg Phe Glu Cys Val   Leu Thr Arg 
    12425                 12430                 12435             


Glu Ala   Asn Val Ile Trp Ser   Lys Gly Pro Asp Ile   Ile Lys Ser 
    12440                 12445                 12450             


Ser Asp   Lys Phe Asp Ile Ile   Ala Asp Gly Lys Lys   His Ile Leu 
    12455                 12460                 12465             


Val Ile   Asn Asp Ser Gln Phe   Asp Asp Glu Gly Val   Tyr Thr Ala 
    12470                 12475                 12480             


Glu Val   Glu Gly Lys Lys Thr   Ser Ala Arg Leu Phe   Val Thr Gly 
    12485                 12490                 12495             


Ile Arg   Leu Lys Phe Met Ser   Pro Leu Glu Asp Gln   Thr Val Lys 
    12500                 12505                 12510             


Glu Gly   Glu Thr Ala Thr Phe   Val Cys Glu Leu Ser   His Glu Lys 
    12515                 12520                 12525             


Met His   Val Val Trp Phe Lys   Asn Asp Ala Lys Leu   His Thr Ser 
    12530                 12535                 12540             


Arg Thr   Val Leu Ile Ser Ser   Glu Gly Lys Thr His   Lys Leu Glu 
    12545                 12550                 12555             


Met Lys   Glu Val Thr Leu Asp   Asp Ile Ser Gln Ile   Lys Ala Gln 
    12560                 12565                 12570             


Val Lys   Glu Leu Ser Ser Thr   Ala Gln Leu Lys Val   Leu Glu Ala 
    12575                 12580                 12585             


Asp Pro   Tyr Phe Thr Val Lys   Leu His Asp Lys Thr   Ala Val Glu 
    12590                 12595                 12600             


Lys Asp   Glu Ile Thr Leu Lys   Cys Glu Val Ser Lys   Asp Val Pro 
    12605                 12610                 12615             


Val Lys   Trp Phe Lys Asp Gly   Glu Glu Ile Val Pro   Ser Pro Lys 
    12620                 12625                 12630             


Tyr Ser   Ile Lys Ala Asp Gly   Leu Arg Arg Ile Leu   Lys Ile Lys 
    12635                 12640                 12645             


Lys Ala   Asp Leu Lys Asp Lys   Gly Glu Tyr Val Cys   Asp Cys Gly 
    12650                 12655                 12660             


Thr Asp   Lys Thr Lys Ala Asn   Val Thr Val Glu Ala   Arg Leu Ile 
    12665                 12670                 12675             


Lys Val   Glu Lys Pro Leu Tyr   Gly Val Glu Val Phe   Val Gly Glu 
    12680                 12685                 12690             


Thr Ala   His Phe Glu Ile Glu   Leu Ser Glu Pro Asp   Val His Gly 
    12695                 12700                 12705             


Gln Trp   Lys Leu Lys Gly Gln   Pro Leu Thr Ala Ser   Pro Asp Cys 
    12710                 12715                 12720             


Glu Ile   Ile Glu Asp Gly Lys   Lys His Ile Leu Ile   Leu His Asn 
    12725                 12730                 12735             


Cys Gln   Leu Gly Met Thr Gly   Glu Val Ser Phe Gln   Ala Ala Asn 
    12740                 12745                 12750             


Ala Lys   Ser Ala Ala Asn Leu   Lys Val Lys Glu Leu   Pro Leu Ile 
    12755                 12760                 12765             


Phe Ile   Thr Pro Leu Ser Asp   Val Lys Val Phe Glu   Lys Asp Glu 
    12770                 12775                 12780             


Ala Lys   Phe Glu Cys Glu Val   Ser Arg Glu Pro Lys   Thr Phe Arg 
    12785                 12790                 12795             


Trp Leu   Lys Gly Thr Gln Glu   Ile Thr Gly Asp Asp   Arg Phe Glu 
    12800                 12805                 12810             


Leu Ile   Lys Asp Gly Thr Lys   His Ser Met Val Ile   Lys Ser Ala 
    12815                 12820                 12825             


Ala Phe   Glu Asp Glu Ala Lys   Tyr Met Phe Glu Ala   Glu Asp Lys 
    12830                 12835                 12840             


His Thr   Ser Gly Lys Leu Ile   Ile Glu Gly Ile Arg   Leu Lys Phe 
    12845                 12850                 12855             


Leu Thr   Pro Leu Lys Asp Val   Thr Ala Lys Glu Lys   Glu Ser Ala 
    12860                 12865                 12870             


Val Phe   Thr Val Glu Leu Ser   His Asp Asn Ile Arg   Val Lys Trp 
    12875                 12880                 12885             


Phe Lys   Asn Asp Gln Arg Leu   His Thr Thr Arg Ser   Val Ser Met 
    12890                 12895                 12900             


Gln Asp   Glu Gly Lys Thr His   Ser Ile Thr Phe Lys   Asp Leu Ser 
    12905                 12910                 12915             


Ile Asp   Asp Thr Ser Gln Ile   Arg Val Glu Ala Met   Gly Met Ser 
    12920                 12925                 12930             


Ser Glu   Ala Lys Leu Thr Val   Leu Glu Gly Asp Pro   Tyr Phe Thr 
    12935                 12940                 12945             


Gly Lys   Leu Gln Asp Tyr Thr   Gly Val Glu Lys Asp   Glu Val Ile 
    12950                 12955                 12960             


Leu Gln   Cys Glu Ile Ser Lys   Ala Asp Ala Pro Val   Lys Trp Phe 
    12965                 12970                 12975             


Lys Asp   Gly Lys Glu Ile Lys   Pro Ser Lys Asn Ala   Val Ile Lys 
    12980                 12985                 12990             


Ala Asp   Gly Lys Lys Arg Met   Leu Ile Leu Lys Lys   Ala Leu Lys 
    12995                 13000                 13005             


Ser Asp   Ile Gly Gln Tyr Thr   Cys Asp Cys Gly Thr   Asp Lys Thr 
    13010                 13015                 13020             


Ser Gly   Lys Leu Asp Ile Glu   Asp Arg Glu Ile Lys   Leu Val Arg 
    13025                 13030                 13035             


Pro Leu   His Ser Val Glu Val   Met Glu Thr Glu Thr   Ala Arg Phe 
    13040                 13045                 13050             


Glu Thr   Glu Ile Ser Glu Asp   Asp Ile His Ala Asn   Trp Lys Leu 
    13055                 13060                 13065             


Lys Gly   Glu Ala Leu Leu Gln   Thr Pro Asp Cys Glu   Ile Lys Glu 
    13070                 13075                 13080             


Glu Gly   Lys Ile His Ser Leu   Val Leu His Asn Cys   Arg Leu Asp 
    13085                 13090                 13095             


Gln Thr   Gly Gly Val Asp Phe   Gln Ala Ala Asn Val   Lys Ser Ser 
    13100                 13105                 13110             


Ala His   Leu Arg Val Lys Pro   Arg Val Ile Gly Leu   Leu Arg Pro 
    13115                 13120                 13125             


Leu Lys   Asp Val Thr Val Thr   Ala Gly Glu Thr Ala   Thr Phe Asp 
    13130                 13135                 13140             


Cys Glu   Leu Ser Tyr Glu Asp   Ile Pro Val Glu Trp   Tyr Leu Lys 
    13145                 13150                 13155             


Gly Lys   Lys Leu Glu Pro Ser   Asp Lys Val Val Pro   Arg Ser Glu 
    13160                 13165                 13170             


Gly Lys   Val His Thr Leu Thr   Leu Arg Asp Val Lys   Leu Glu Asp 
    13175                 13180                 13185             


Ala Gly   Glu Val Gln Leu Thr   Ala Lys Asp Phe Lys   Thr His Ala 
    13190                 13195                 13200             


Asn Leu   Phe Val Lys Glu Pro   Pro Val Glu Phe Thr   Lys Pro Leu 
    13205                 13210                 13215             


Glu Asp   Gln Thr Val Glu Glu   Gly Ala Thr Ala Val   Leu Glu Cys 
    13220                 13225                 13230             


Glu Val   Ser Arg Glu Asn Ala   Lys Val Lys Trp Phe   Lys Asn Gly 
    13235                 13240                 13245             


Thr Glu   Ile Leu Lys Ser Lys   Lys Tyr Glu Ile Val   Ala Asp Gly 
    13250                 13255                 13260             


Arg Val   Arg Lys Leu Val Ile   His Asp Cys Thr Pro   Glu Asp Ile 
    13265                 13270                 13275             


Lys Thr   Tyr Thr Cys Asp Ala   Lys Asp Phe Lys Thr   Ser Cys Asn 
    13280                 13285                 13290             


Leu Asn   Val Val Pro Pro His   Val Glu Phe Leu Arg   Pro Leu Thr 
    13295                 13300                 13305             


Asp Leu   Gln Val Arg Glu Lys   Glu Met Ala Arg Phe   Glu Cys Glu 
    13310                 13315                 13320             


Leu Ser   Arg Glu Asn Ala Lys   Val Lys Trp Phe Lys   Asp Gly Ala 
    13325                 13330                 13335             


Glu Ile   Lys Lys Gly Lys Lys   Tyr Asp Ile Ile Ser   Lys Gly Ala 
    13340                 13345                 13350             


Val Arg   Ile Leu Val Ile Asn   Lys Cys Leu Leu Asp   Asp Glu Ala 
    13355                 13360                 13365             


Glu Tyr   Ser Cys Glu Val Arg   Thr Ala Arg Thr Ser   Gly Met Leu 
    13370                 13375                 13380             


Thr Val   Leu Glu Glu Glu Ala   Val Phe Thr Lys Asn   Leu Ala Asn 
    13385                 13390                 13395             


Ile Glu   Val Ser Glu Thr Asp   Thr Ile Lys Leu Val   Cys Glu Val 
    13400                 13405                 13410             


Ser Lys   Pro Gly Ala Glu Val   Ile Trp Tyr Lys Gly   Asp Glu Glu 
    13415                 13420                 13425             


Ile Ile   Glu Thr Gly Arg Tyr   Glu Ile Leu Thr Glu   Gly Arg Lys 
    13430                 13435                 13440             


Arg Ile   Leu Val Ile Gln Asn   Ala His Leu Glu Asp   Ala Gly Asn 
    13445                 13450                 13455             


Tyr Asn   Cys Arg Leu Pro Ser   Ser Arg Thr Asp Gly   Lys Val Lys 
    13460                 13465                 13470             


Val His   Glu Leu Ala Ala Glu   Phe Ile Ser Lys Pro   Gln Asn Leu 
    13475                 13480                 13485             


Glu Ile   Leu Glu Gly Glu Lys   Ala Glu Phe Val Cys   Ser Ile Ser 
    13490                 13495                 13500             


Lys Glu   Ser Phe Pro Val Gln   Trp Lys Arg Asp Asp   Lys Thr Leu 
    13505                 13510                 13515             


Glu Ser   Gly Asp Lys Tyr Asp   Val Ile Ala Asp Gly   Lys Lys Arg 
    13520                 13525                 13530             


Val Leu   Val Val Lys Asp Ala   Thr Leu Gln Asp Met   Gly Thr Tyr 
    13535                 13540                 13545             


Val Val   Met Val Gly Ala Ala   Arg Ala Ala Ala His   Leu Thr Val 
    13550                 13555                 13560             


Ile Glu   Lys Leu Arg Ile Val   Val Pro Leu Lys Asp   Thr Arg Val 
    13565                 13570                 13575             


Lys Glu   Gln Gln Glu Val Val   Phe Asn Cys Glu Val   Asn Thr Glu 
    13580                 13585                 13590             


Gly Ala   Lys Ala Lys Trp Phe   Arg Asn Glu Glu Ala   Ile Phe Asp 
    13595                 13600                 13605             


Ser Ser   Lys Tyr Ile Ile Leu   Gln Lys Asp Leu Val   Tyr Thr Leu 
    13610                 13615                 13620             


Arg Ile   Arg Asp Ala His Leu   Asp Asp Gln Ala Asn   Tyr Asn Val 
    13625                 13630                 13635             


Ser Leu   Thr Asn His Arg Gly   Glu Asn Val Lys Ser   Ala Ala Asn 
    13640                 13645                 13650             


Leu Ile   Val Glu Glu Glu Asp   Leu Arg Ile Val Glu   Pro Leu Lys 
    13655                 13660                 13665             


Asp Ile   Glu Thr Met Glu Lys   Lys Ser Val Thr Phe   Trp Cys Lys 
    13670                 13675                 13680             


Val Asn   Arg Leu Asn Val Thr   Leu Lys Trp Thr Lys   Asn Gly Glu 
    13685                 13690                 13695             


Glu Val   Pro Phe Asp Asn Arg   Val Ser Tyr Arg Val   Asp Lys Tyr 
    13700                 13705                 13710             


Lys His   Met Leu Thr Ile Lys   Asp Cys Gly Phe Pro   Asp Glu Gly 
    13715                 13720                 13725             


Glu Tyr   Ile Val Thr Ala Gly   Gln Asp Lys Ser Val   Ala Glu Leu 
    13730                 13735                 13740             


Leu Ile   Ile Glu Ala Pro Thr   Glu Phe Val Glu His   Leu Glu Asp 
    13745                 13750                 13755             


Gln Thr   Val Thr Glu Phe Asp   Asp Ala Val Phe Ser   Cys Gln Leu 
    13760                 13765                 13770             


Ser Arg   Glu Lys Ala Asn Val   Lys Trp Tyr Arg Asn   Gly Arg Glu 
    13775                 13780                 13785             


Ile Lys   Glu Gly Lys Lys Tyr   Lys Phe Glu Lys Asp   Gly Ser Ile 
    13790                 13795                 13800             


His Arg   Leu Ile Ile Lys Asp   Cys Arg Leu Asp Asp   Glu Cys Glu 
    13805                 13810                 13815             


Tyr Ala   Cys Gly Val Glu Asp   Arg Lys Ser Arg Ala   Arg Leu Phe 
    13820                 13825                 13830             


Val Glu   Glu Ile Pro Val Glu   Ile Ile Arg Pro Pro   Gln Asp Ile 
    13835                 13840                 13845             


Leu Glu   Ala Pro Gly Ala Asp   Val Val Phe Leu Ala   Glu Leu Asn 
    13850                 13855                 13860             


Lys Asp   Lys Val Glu Val Gln   Trp Leu Arg Asn Asn   Met Val Val 
    13865                 13870                 13875             


Val Gln   Gly Asp Lys His Gln   Met Met Ser Glu Gly   Lys Ile His 
    13880                 13885                 13890             


Arg Leu   Gln Ile Cys Asp Ile   Lys Pro Arg Asp Gln   Gly Glu Tyr 
    13895                 13900                 13905             


Arg Phe   Ile Ala Lys Asp Lys   Glu Ala Arg Ala Lys   Leu Glu Leu 
    13910                 13915                 13920             


Ala Ala   Ala Pro Lys Ile Lys   Thr Ala Asp Gln Asp   Leu Val Val 
    13925                 13930                 13935             


Asp Val   Gly Lys Pro Leu Thr   Met Val Val Pro Tyr   Asp Ala Tyr 
    13940                 13945                 13950             


Pro Lys   Ala Glu Ala Glu Trp   Phe Lys Glu Asn Glu   Pro Leu Ser 
    13955                 13960                 13965             


Thr Lys   Thr Ile Asp Thr Thr   Ala Glu Gln Thr Ser   Phe Arg Ile 
    13970                 13975                 13980             


Leu Glu   Ala Lys Lys Gly Asp   Lys Gly Arg Tyr Lys   Ile Val Leu 
    13985                 13990                 13995             


Gln Asn   Lys His Gly Lys Ala   Glu Gly Phe Ile Asn   Leu Lys Val 
    14000                 14005                 14010             


Ile Asp   Val Pro Gly Pro Val   Arg Asn Leu Glu Val   Thr Glu Thr 
    14015                 14020                 14025             


Phe Asp   Gly Glu Val Ser Leu   Ala Trp Glu Glu Pro   Leu Thr Asp 
    14030                 14035                 14040             


Gly Gly   Ser Lys Ile Ile Gly   Tyr Val Val Glu Arg   Arg Asp Ile 
    14045                 14050                 14055             


Lys Arg   Lys Thr Trp Val Leu   Ala Thr Asp Arg Ala   Glu Ser Cys 
    14060                 14065                 14070             


Glu Phe   Thr Val Thr Gly Leu   Gln Lys Gly Gly Val   Glu Tyr Leu 
    14075                 14080                 14085             


Phe Arg   Val Ser Ala Arg Asn   Arg Val Gly Thr Gly   Glu Pro Val 
    14090                 14095                 14100             


Glu Thr   Asp Asn Pro Val Glu   Ala Arg Ser Lys Tyr   Asp Val Pro 
    14105                 14110                 14115             


Gly Pro   Pro Leu Asn Val Thr   Ile Thr Asp Val Asn   Arg Phe Gly 
    14120                 14125                 14130             


Val Ser   Leu Thr Trp Glu Pro   Pro Glu Tyr Asp Gly   Gly Ala Glu 
    14135                 14140                 14145             


Ile Thr   Asn Tyr Val Ile Glu   Leu Arg Asp Lys Thr   Ser Ile Arg 
    14150                 14155                 14160             


Trp Asp   Thr Ala Met Thr Val   Arg Ala Glu Asp Leu   Ser Ala Thr 
    14165                 14170                 14175             


Val Thr   Asp Val Val Glu Gly   Gln Glu Tyr Ser Phe   Arg Val Arg 
    14180                 14185                 14190             


Ala Gln   Asn Arg Ile Gly Val   Gly Lys Pro Ser Ala   Ala Thr Pro 
    14195                 14200                 14205             


Phe Val   Lys Val Ala Asp Pro   Ile Glu Arg Pro Ser   Pro Pro Val 
    14210                 14215                 14220             


Asn Leu   Thr Ser Ser Asp Gln   Thr Gln Ser Ser Val   Gln Leu Lys 
    14225                 14230                 14235             


Trp Glu   Pro Pro Leu Lys Asp   Gly Gly Ser Pro Ile   Leu Gly Tyr 
    14240                 14245                 14250             


Ile Ile   Glu Arg Cys Glu Glu   Gly Lys Asp Asn Trp   Ile Arg Cys 
    14255                 14260                 14265             


Asn Met   Lys Leu Val Pro Glu   Leu Thr Tyr Lys Val   Thr Gly Leu 
    14270                 14275                 14280             


Glu Lys   Gly Asn Lys Tyr Leu   Tyr Arg Val Ser Ala   Glu Asn Lys 
    14285                 14290                 14295             


Ala Gly   Val Ser Asp Pro Ser   Glu Ile Leu Gly Pro   Leu Thr Ala 
    14300                 14305                 14310             


Asp Asp   Ala Phe Val Glu Pro   Thr Met Asp Leu Ser   Ala Phe Lys 
    14315                 14320                 14325             


Asp Gly   Leu Glu Val Ile Val   Pro Asn Pro Ile Thr   Ile Leu Val 
    14330                 14335                 14340             


Pro Ser   Thr Gly Tyr Pro Arg   Pro Thr Ala Thr Trp   Cys Phe Gly 
    14345                 14350                 14355             


Asp Lys   Val Leu Glu Thr Gly   Asp Arg Val Lys Met   Lys Thr Leu 
    14360                 14365                 14370             


Ser Ala   Tyr Ala Glu Leu Val   Ile Ser Pro Ser Glu   Arg Ser Asp 
    14375                 14380                 14385             


Lys Gly   Ile Tyr Thr Leu Lys   Leu Glu Asn Arg Val   Lys Thr Ile 
    14390                 14395                 14400             


Ser Gly   Glu Ile Asp Val Asn   Val Ile Ala Arg Pro   Ser Ala Pro 
    14405                 14410                 14415             


Lys Glu   Leu Lys Phe Gly Asp   Ile Thr Lys Asp Ser   Val His Leu 
    14420                 14425                 14430             


Thr Trp   Glu Pro Pro Asp Asp   Asp Gly Gly Ser Pro   Leu Thr Gly 
    14435                 14440                 14445             


Tyr Val   Val Glu Lys Arg Glu   Val Ser Arg Lys Thr   Trp Thr Lys 
    14450                 14455                 14460             


Val Met   Asp Phe Val Thr Asp   Leu Glu Phe Thr Val   Pro Asp Leu 
    14465                 14470                 14475             


Val Gln   Gly Lys Glu Tyr Leu   Phe Lys Val Cys Ala   Arg Asn Lys 
    14480                 14485                 14490             


Cys Gly   Pro Gly Glu Pro Ala   Tyr Val Asp Glu Pro   Val Asn Met 
    14495                 14500                 14505             


Ser Thr   Pro Ala Thr Val Pro   Asp Pro Pro Glu Asn   Val Lys Trp 
    14510                 14515                 14520             


Arg Asp   Arg Thr Ala Asn Ser   Ile Phe Leu Thr Trp   Asp Pro Pro 
    14525                 14530                 14535             


Lys Asn   Asp Gly Gly Ser Arg   Ile Lys Gly Tyr Ile   Val Glu Arg 
    14540                 14545                 14550             


Cys Pro   Arg Gly Ser Asp Lys   Trp Val Ala Cys Gly   Glu Pro Val 
    14555                 14560                 14565             


Ala Glu   Thr Lys Met Glu Val   Thr Gly Leu Glu Glu   Gly Lys Trp 
    14570                 14575                 14580             


Tyr Ala   Tyr Arg Val Lys Ala   Leu Asn Arg Gln Gly   Ala Ser Lys 
    14585                 14590                 14595             


Pro Ser   Arg Pro Thr Glu Glu   Ile Gln Ala Val Asp   Thr Gln Glu 
    14600                 14605                 14610             


Ala Pro   Glu Ile Phe Leu Asp   Val Lys Leu Leu Ala   Gly Leu Thr 
    14615                 14620                 14625             


Val Lys   Ala Gly Thr Lys Ile   Glu Leu Pro Ala Thr   Val Thr Gly 
    14630                 14635                 14640             


Lys Pro   Glu Pro Lys Ile Thr   Trp Thr Lys Ala Asp   Met Ile Leu 
    14645                 14650                 14655             


Lys Gln   Asp Lys Arg Ile Thr   Ile Glu Asn Val Pro   Lys Lys Ser 
    14660                 14665                 14670             


Thr Val   Thr Ile Val Asp Ser   Lys Arg Ser Asp Thr   Gly Thr Tyr 
    14675                 14680                 14685             


Ile Ile   Glu Ala Val Asn Val   Cys Gly Arg Ala Thr   Ala Val Val 
    14690                 14695                 14700             


Glu Val   Asn Val Leu Asp Lys   Pro Gly Pro Pro Ala   Ala Phe Asp 
    14705                 14710                 14715             


Ile Thr   Asp Val Thr Asn Glu   Ser Cys Leu Leu Thr   Trp Asn Pro 
    14720                 14725                 14730             


Pro Arg   Asp Asp Gly Gly Ser   Lys Ile Thr Asn Tyr   Val Val Glu 
    14735                 14740                 14745             


Arg Arg   Ala Thr Asp Ser Glu   Val Trp His Lys Leu   Ser Ser Thr 
    14750                 14755                 14760             


Val Lys   Asp Thr Asn Phe Lys   Ala Thr Lys Leu Ile   Pro Asn Lys 
    14765                 14770                 14775             


Glu Tyr   Ile Phe Arg Val Ala   Ala Glu Asn Met Tyr   Gly Val Gly 
    14780                 14785                 14790             


Glu Pro   Val Gln Ala Ser Pro   Ile Thr Ala Lys Tyr   Gln Phe Asp 
    14795                 14800                 14805             


Pro Pro   Gly Pro Pro Thr Arg   Leu Glu Pro Ser Asp   Ile Thr Lys 
    14810                 14815                 14820             


Asp Ala   Val Thr Leu Thr Trp   Cys Glu Pro Asp Asp   Asp Gly Gly 
    14825                 14830                 14835             


Ser Pro   Ile Thr Gly Tyr Trp   Val Glu Arg Leu Asp   Pro Asp Thr 
    14840                 14845                 14850             


Asp Lys   Trp Val Arg Cys Asn   Lys Met Pro Val Lys   Asp Thr Thr 
    14855                 14860                 14865             


Tyr Arg   Val Lys Gly Leu Thr   Asn Lys Lys Lys Tyr   Arg Phe Arg 
    14870                 14875                 14880             


Val Leu   Ala Glu Asn Leu Ala   Gly Pro Gly Lys Pro   Ser Lys Ser 
    14885                 14890                 14895             


Thr Glu   Pro Ile Leu Ile Lys   Asp Pro Ile Asp Pro   Pro Trp Pro 
    14900                 14905                 14910             


Pro Gly   Lys Pro Thr Val Lys   Asp Val Gly Lys Thr   Ser Val Arg 
    14915                 14920                 14925             


Leu Asn   Trp Thr Lys Pro Glu   His Asp Gly Gly Ala   Lys Ile Glu 
    14930                 14935                 14940             


Ser Tyr   Val Ile Glu Met Leu   Lys Thr Gly Thr Asp   Glu Trp Val 
    14945                 14950                 14955             


Arg Val   Ala Glu Gly Val Pro   Thr Thr Gln His Leu   Leu Pro Gly 
    14960                 14965                 14970             


Leu Met   Glu Gly Gln Glu Tyr   Ser Phe Arg Val Arg   Ala Val Asn 
    14975                 14980                 14985             


Lys Ala   Gly Glu Ser Glu Pro   Ser Glu Pro Ser Asp   Pro Val Leu 
    14990                 14995                 15000             


Cys Arg   Glu Lys Leu Tyr Pro   Pro Ser Pro Pro Arg   Trp Leu Glu 
    15005                 15010                 15015             


Val Ile   Asn Ile Thr Lys Asn   Thr Ala Asp Leu Lys   Trp Thr Val 
    15020                 15025                 15030             


Pro Glu   Lys Asp Gly Gly Ser   Pro Ile Thr Asn Tyr   Ile Val Glu 
    15035                 15040                 15045             


Lys Arg   Asp Val Arg Arg Lys   Gly Trp Gln Thr Val   Asp Thr Thr 
    15050                 15055                 15060             


Val Lys   Asp Thr Lys Cys Thr   Val Thr Pro Leu Thr   Glu Gly Ser 
    15065                 15070                 15075             


Leu Tyr   Val Phe Arg Val Ala   Ala Glu Asn Ala Ile   Gly Gln Ser 
    15080                 15085                 15090             


Asp Tyr   Thr Glu Ile Glu Asp   Ser Val Leu Ala Lys   Asp Thr Phe 
    15095                 15100                 15105             


Thr Thr   Pro Gly Pro Pro Tyr   Ala Leu Ala Val Val   Asp Val Thr 
    15110                 15115                 15120             


Lys Arg   His Val Asp Leu Lys   Trp Glu Pro Pro Lys   Asn Asp Gly 
    15125                 15130                 15135             


Gly Arg   Pro Ile Gln Arg Tyr   Val Ile Glu Lys Lys   Glu Arg Leu 
    15140                 15145                 15150             


Gly Thr   Arg Trp Val Lys Ala   Gly Lys Thr Ala Gly   Pro Asp Cys 
    15155                 15160                 15165             


Asn Phe   Arg Val Thr Asp Val   Ile Glu Gly Thr Glu   Val Gln Phe 
    15170                 15175                 15180             


Gln Val   Arg Ala Glu Asn Glu   Ala Gly Val Gly His   Pro Ser Glu 
    15185                 15190                 15195             


Pro Thr   Glu Ile Leu Ser Ile   Glu Asp Pro Thr Ser   Pro Pro Ser 
    15200                 15205                 15210             


Pro Pro   Leu Asp Leu His Val   Thr Asp Ala Gly Arg   Lys His Ile 
    15215                 15220                 15225             


Ala Ile   Ala Trp Lys Pro Pro   Glu Lys Asn Gly Gly   Ser Pro Ile 
    15230                 15235                 15240             


Ile Gly   Tyr His Val Glu Met   Cys Pro Val Gly Thr   Glu Lys Trp 
    15245                 15250                 15255             


Met Arg   Val Asn Ser Arg Pro   Ile Lys Asp Leu Lys   Phe Lys Val 
    15260                 15265                 15270             


Glu Glu   Gly Val Val Pro Asp   Lys Glu Tyr Val Leu   Arg Val Arg 
    15275                 15280                 15285             


Ala Val   Asn Ala Ile Gly Val   Ser Glu Pro Ser Glu   Ile Ser Glu 
    15290                 15295                 15300             


Asn Val   Val Ala Lys Asp Pro   Asp Cys Lys Pro Thr   Ile Asp Leu 
    15305                 15310                 15315             


Glu Thr   His Asp Ile Ile Val   Ile Glu Gly Glu Lys   Leu Ser Ile 
    15320                 15325                 15330             


Pro Val   Pro Phe Arg Ala Val   Pro Val Pro Thr Val   Ser Trp His 
    15335                 15340                 15345             


Lys Asp   Gly Lys Glu Val Lys   Ala Ser Asp Arg Leu   Thr Met Lys 
    15350                 15355                 15360             


Asn Asp   His Ile Ser Ala His   Leu Glu Val Pro Lys   Ser Val Arg 
    15365                 15370                 15375             


Ala Asp   Ala Gly Ile Tyr Thr   Ile Thr Leu Glu Asn   Lys Leu Gly 
    15380                 15385                 15390             


Ser Ala   Thr Ala Ser Ile Asn   Val Lys Val Ile Gly   Leu Pro Gly 
    15395                 15400                 15405             


Pro Cys   Lys Asp Ile Lys Ala   Ser Asp Ile Thr Lys   Ser Ser Cys 
    15410                 15415                 15420             


Lys Leu   Thr Trp Glu Pro Pro   Glu Phe Asp Gly Gly   Thr Pro Ile 
    15425                 15430                 15435             


Leu His   Tyr Val Leu Glu Arg   Arg Glu Ala Gly Arg   Arg Thr Tyr 
    15440                 15445                 15450             


Ile Pro   Val Met Ser Gly Glu   Asn Lys Leu Ser Trp   Thr Val Lys 
    15455                 15460                 15465             


Asp Leu   Ile Pro Asn Gly Glu   Tyr Phe Phe Arg Val   Lys Ala Val 
    15470                 15475                 15480             


Asn Lys   Val Gly Gly Gly Glu   Tyr Ile Glu Leu Lys   Asn Pro Val 
    15485                 15490                 15495             


Ile Ala   Gln Asp Pro Lys Gln   Pro Pro Asp Pro Pro   Val Asp Val 
    15500                 15505                 15510             


Glu Val   His Asn Pro Thr Ala   Glu Ala Met Thr Ile   Thr Trp Lys 
    15515                 15520                 15525             


Pro Pro   Leu Tyr Asp Gly Gly   Ser Lys Ile Met Gly   Tyr Ile Ile 
    15530                 15535                 15540             


Glu Lys   Ile Ala Lys Gly Glu   Glu Arg Trp Lys Arg   Cys Asn Glu 
    15545                 15550                 15555             


His Leu   Val Pro Ile Leu Thr   Tyr Thr Ala Lys Gly   Leu Glu Glu 
    15560                 15565                 15570             


Gly Lys   Glu Tyr Gln Phe Arg   Val Arg Ala Glu Asn   Ala Ala Gly 
    15575                 15580                 15585             


Ile Ser   Glu Pro Ser Arg Ala   Thr Pro Pro Thr Lys   Ala Val Asp 
    15590                 15595                 15600             


Pro Ile   Asp Ala Pro Lys Val   Ile Leu Arg Thr Ser   Leu Glu Val 
    15605                 15610                 15615             


Lys Arg   Gly Asp Glu Ile Ala   Leu Asp Ala Ser Ile   Ser Gly Ser 
    15620                 15625                 15630             


Pro Tyr   Pro Thr Ile Thr Trp   Ile Lys Asp Glu Asn   Val Ile Val 
    15635                 15640                 15645             


Pro Glu   Glu Ile Lys Lys Arg   Ala Ala Pro Leu Val   Arg Arg Arg 
    15650                 15655                 15660             


Lys Gly   Glu Val Gln Glu Glu   Glu Pro Phe Val Leu   Pro Leu Thr 
    15665                 15670                 15675             


Gln Arg   Leu Ser Ile Asp Asn   Ser Lys Lys Gly Glu   Ser Gln Leu 
    15680                 15685                 15690             


Arg Val   Arg Asp Ser Leu Arg   Pro Asp His Gly Leu   Tyr Met Ile 
    15695                 15700                 15705             


Lys Val   Glu Asn Asp His Gly   Ile Ala Lys Ala Pro   Cys Thr Val 
    15710                 15715                 15720             


Ser Val   Leu Asp Thr Pro Gly   Pro Pro Ile Asn Phe   Val Phe Glu 
    15725                 15730                 15735             


Asp Ile   Arg Lys Thr Ser Val   Leu Cys Lys Trp Glu   Pro Pro Leu 
    15740                 15745                 15750             


Asp Asp   Gly Gly Ser Glu Ile   Ile Asn Tyr Thr Leu   Glu Lys Lys 
    15755                 15760                 15765             


Asp Lys   Thr Lys Pro Asp Ser   Glu Trp Ile Val Val   Thr Ser Thr 
    15770                 15775                 15780             


Leu Arg   His Cys Lys Tyr Ser   Val Thr Lys Leu Ile   Glu Gly Lys 
    15785                 15790                 15795             


Glu Tyr   Leu Phe Arg Val Arg   Ala Glu Asn Arg Phe   Gly Pro Gly 
    15800                 15805                 15810             


Pro Pro   Cys Val Ser Lys Pro   Leu Val Ala Lys Asp   Pro Phe Gly 
    15815                 15820                 15825             


Pro Pro   Asp Ala Pro Asp Lys   Pro Ile Val Glu Asp   Val Thr Ser 
    15830                 15835                 15840             


Asn Ser   Met Leu Val Lys Trp   Asn Glu Pro Lys Asp   Asn Gly Ser 
    15845                 15850                 15855             


Pro Ile   Leu Gly Tyr Trp Leu   Glu Lys Arg Glu Val   Asn Ser Thr 
    15860                 15865                 15870             


His Trp   Ser Arg Val Asn Lys   Ser Leu Leu Asn Ala   Leu Lys Ala 
    15875                 15880                 15885             


Asn Val   Asp Gly Leu Leu Glu   Gly Leu Thr Tyr Val   Phe Arg Val 
    15890                 15895                 15900             


Cys Ala   Glu Asn Ala Ala Gly   Pro Gly Lys Phe Ser   Pro Pro Ser 
    15905                 15910                 15915             


Asp Pro   Lys Thr Ala His Asp   Pro Ile Ser Pro Pro   Gly Pro Pro 
    15920                 15925                 15930             


Ile Pro   Arg Val Thr Asp Thr   Ser Ser Thr Thr Ile   Glu Leu Glu 
    15935                 15940                 15945             


Trp Glu   Pro Pro Ala Phe Asn   Gly Gly Gly Glu Ile   Val Gly Tyr 
    15950                 15955                 15960             


Phe Val   Asp Lys Gln Leu Val   Gly Thr Asn Glu Trp   Ser Arg Cys 
    15965                 15970                 15975             


Thr Glu   Lys Met Ile Lys Val   Arg Gln Tyr Thr Val   Lys Glu Ile 
    15980                 15985                 15990             


Arg Glu   Gly Ala Asp Tyr Lys   Leu Arg Val Ser Ala   Val Asn Ala 
    15995                 16000                 16005             


Ala Gly   Glu Gly Pro Pro Gly   Glu Thr Gln Pro Val   Thr Val Ala 
    16010                 16015                 16020             


Glu Pro   Gln Glu Pro Pro Ala   Val Glu Leu Asp Val   Ser Val Lys 
    16025                 16030                 16035             


Gly Gly   Ile Gln Ile Met Ala   Gly Lys Thr Leu Arg   Ile Pro Ala 
    16040                 16045                 16050             


Val Val   Thr Gly Arg Pro Val   Pro Thr Lys Val Trp   Thr Lys Glu 
    16055                 16060                 16065             


Glu Gly   Glu Leu Asp Lys Asp   Arg Val Val Ile Asp   Asn Val Gly 
    16070                 16075                 16080             


Thr Lys   Ser Glu Leu Ile Ile   Lys Asp Ala Leu Arg   Lys Asp His 
    16085                 16090                 16095             


Gly Arg   Tyr Val Ile Thr Ala   Thr Asn Ser Cys Gly   Ser Lys Phe 
    16100                 16105                 16110             


Ala Ala   Ala Arg Val Glu Val   Phe Asp Val Pro Gly   Pro Val Leu 
    16115                 16120                 16125             


Asp Leu   Lys Pro Val Val Thr   Asn Arg Lys Met Cys   Leu Leu Asn 
    16130                 16135                 16140             


Trp Ser   Asp Pro Glu Asp Asp   Gly Gly Ser Glu Ile   Thr Gly Phe 
    16145                 16150                 16155             


Ile Ile   Glu Arg Lys Asp Ala   Lys Met His Thr Trp   Arg Gln Pro 
    16160                 16165                 16170             


Ile Glu   Thr Glu Arg Ser Lys   Cys Asp Ile Thr Gly   Leu Leu Glu 
    16175                 16180                 16185             


Gly Gln   Glu Tyr Lys Phe Arg   Val Ile Ala Lys Asn   Lys Phe Gly 
    16190                 16195                 16200             


Cys Gly   Pro Pro Val Glu Ile   Gly Pro Ile Leu Ala   Val Asp Pro 
    16205                 16210                 16215             


Leu Gly   Pro Pro Thr Ser Pro   Glu Arg Leu Thr Tyr   Thr Glu Arg 
    16220                 16225                 16230             


Thr Lys   Ser Thr Ile Thr Leu   Asp Trp Lys Glu Pro   Arg Ser Asn 
    16235                 16240                 16245             


Gly Gly   Ser Pro Ile Gln Gly   Tyr Ile Ile Glu Lys   Arg Arg His 
    16250                 16255                 16260             


Asp Lys   Pro Asp Phe Glu Arg   Val Asn Lys Arg Leu   Cys Pro Thr 
    16265                 16270                 16275             


Thr Ser   Phe Leu Val Glu Asn   Leu Asp Glu His Gln   Met Tyr Glu 
    16280                 16285                 16290             


Phe Arg   Val Lys Ala Val Asn   Glu Ile Gly Glu Ser   Glu Pro Ser 
    16295                 16300                 16305             


Leu Pro   Leu Asn Val Val Ile   Gln Asp Asp Glu Val   Pro Pro Thr 
    16310                 16315                 16320             


Ile Lys   Leu Arg Leu Ser Val   Arg Gly Asp Thr Ile   Lys Val Lys 
    16325                 16330                 16335             


Ala Gly   Glu Pro Val His Ile   Pro Ala Asp Val Thr   Gly Leu Pro 
    16340                 16345                 16350             


Met Pro   Lys Ile Glu Trp Ser   Lys Asn Glu Thr Val   Ile Glu Lys 
    16355                 16360                 16365             


Pro Thr   Asp Ala Leu Gln Ile   Thr Lys Glu Glu Val   Ser Arg Ser 
    16370                 16375                 16380             


Glu Ala   Lys Thr Glu Leu Ser   Ile Pro Lys Ala Val   Arg Glu Asp 
    16385                 16390                 16395             


Lys Gly   Thr Tyr Thr Val Thr   Ala Ser Asn Arg Leu   Gly Ser Val 
    16400                 16405                 16410             


Phe Arg   Asn Val His Val Glu   Val Tyr Asp Arg Pro   Ser Pro Pro 
    16415                 16420                 16425             


Arg Asn   Leu Ala Val Thr Asp   Ile Lys Ala Glu Ser   Cys Tyr Leu 
    16430                 16435                 16440             


Thr Trp   Asp Ala Pro Leu Asp   Asn Gly Gly Ser Glu   Ile Thr His 
    16445                 16450                 16455             


Tyr Val   Ile Asp Lys Arg Asp   Ala Ser Arg Lys Lys   Ala Glu Trp 
    16460                 16465                 16470             


Glu Glu   Val Thr Asn Thr Ala   Val Glu Lys Arg Tyr   Gly Ile Trp 
    16475                 16480                 16485             


Lys Leu   Ile Pro Asn Gly Gln   Tyr Glu Phe Arg Val   Arg Ala Val 
    16490                 16495                 16500             


Asn Lys   Tyr Gly Ile Ser Asp   Glu Cys Lys Ser Asp   Lys Val Val 
    16505                 16510                 16515             


Ile Gln   Asp Pro Tyr Arg Leu   Pro Gly Pro Pro Gly   Lys Pro Lys 
    16520                 16525                 16530             


Val Leu   Ala Arg Thr Lys Gly   Ser Met Leu Val Ser   Trp Thr Pro 
    16535                 16540                 16545             


Pro Leu   Asp Asn Gly Gly Ser   Pro Ile Thr Gly Tyr   Trp Leu Glu 
    16550                 16555                 16560             


Lys Arg   Glu Glu Gly Ser Pro   Tyr Trp Ser Arg Val   Ser Arg Ala 
    16565                 16570                 16575             


Pro Ile   Thr Lys Val Gly Leu   Lys Gly Val Glu Phe   Asn Val Pro 
    16580                 16585                 16590             


Arg Leu   Leu Glu Gly Val Lys   Tyr Gln Phe Arg Ala   Met Ala Ile 
    16595                 16600                 16605             


Asn Ala   Ala Gly Ile Gly Pro   Pro Ser Glu Pro Ser   Asp Pro Glu 
    16610                 16615                 16620             


Val Ala   Gly Asp Pro Ile Phe   Pro Pro Gly Pro Pro   Ser Cys Pro 
    16625                 16630                 16635             


Glu Val   Lys Asp Lys Thr Lys   Ser Ser Ile Ser Leu   Gly Trp Lys 
    16640                 16645                 16650             


Pro Pro   Ala Lys Asp Gly Gly   Ser Pro Ile Lys Gly   Tyr Ile Val 
    16655                 16660                 16665             


Glu Met   Gln Glu Glu Gly Thr   Thr Asp Trp Lys Arg   Val Asn Glu 
    16670                 16675                 16680             


Pro Asp   Lys Leu Ile Thr Thr   Cys Glu Cys Val Val   Pro Asn Leu 
    16685                 16690                 16695             


Lys Glu   Leu Arg Lys Tyr Arg   Phe Arg Val Lys Ala   Val Asn Glu 
    16700                 16705                 16710             


Ala Gly   Glu Ser Glu Pro Ser   Asp Thr Thr Gly Glu   Ile Pro Ala 
    16715                 16720                 16725             


Thr Asp   Ile Gln Glu Glu Pro   Glu Val Phe Ile Asp   Ile Gly Ala 
    16730                 16735                 16740             


Gln Asp   Cys Leu Val Cys Lys   Ala Gly Ser Gln Ile   Arg Ile Pro 
    16745                 16750                 16755             


Ala Val   Ile Lys Gly Arg Pro   Thr Pro Lys Ser Ser   Trp Glu Phe 
    16760                 16765                 16770             


Asp Gly   Lys Ala Lys Lys Ala   Met Lys Asp Gly Val   His Asp Ile 
    16775                 16780                 16785             


Pro Glu   Asp Ala Gln Leu Glu   Thr Ala Glu Asn Ser   Ser Val Ile 
    16790                 16795                 16800             


Ile Ile   Pro Glu Cys Lys Arg   Ser His Thr Gly Lys   Tyr Ser Ile 
    16805                 16810                 16815             


Thr Ala   Lys Asn Lys Ala Gly   Gln Lys Thr Ala Asn   Cys Arg Val 
    16820                 16825                 16830             


Lys Val   Met Asp Val Pro Gly   Pro Pro Lys Asp Leu   Lys Val Ser 
    16835                 16840                 16845             


Asp Ile   Thr Arg Gly Ser Cys   Arg Leu Ser Trp Lys   Met Pro Asp 
    16850                 16855                 16860             


Asp Asp   Gly Gly Asp Arg Ile   Lys Gly Tyr Val Ile   Glu Lys Arg 
    16865                 16870                 16875             


Thr Ile   Asp Gly Lys Ala Trp   Thr Lys Val Asn Pro   Asp Cys Gly 
    16880                 16885                 16890             


Ser Thr   Thr Phe Val Val Pro   Asp Leu Leu Ser Glu   Gln Gln Tyr 
    16895                 16900                 16905             


Phe Phe   Arg Val Arg Ala Glu   Asn Arg Phe Gly Ile   Gly Pro Pro 
    16910                 16915                 16920             


Val Glu   Thr Ile Gln Arg Thr   Thr Ala Arg Asp Pro   Ile Tyr Pro 
    16925                 16930                 16935             


Pro Asp   Pro Pro Ile Lys Leu   Lys Ile Gly Leu Ile   Thr Lys Asn 
    16940                 16945                 16950             


Thr Val   His Leu Ser Trp Lys   Pro Pro Lys Asn Asp   Gly Gly Ser 
    16955                 16960                 16965             


Pro Val   Thr His Tyr Ile Val   Glu Cys Leu Ala Trp   Asp Pro Thr 
    16970                 16975                 16980             


Gly Thr   Lys Lys Glu Ala Trp   Arg Gln Cys Asn Lys   Arg Asp Val 
    16985                 16990                 16995             


Glu Glu   Leu Gln Phe Thr Val   Glu Asp Leu Val Glu   Gly Gly Glu 
    17000                 17005                 17010             


Tyr Glu   Phe Arg Val Lys Ala   Val Asn Ala Ala Gly   Val Ser Lys 
    17015                 17020                 17025             


Pro Ser   Ala Thr Val Gly Pro   Val Thr Val Lys Asp   Gln Thr Cys 
    17030                 17035                 17040             


Pro Pro   Ser Ile Asp Leu Lys   Glu Phe Met Glu Val   Glu Glu Gly 
    17045                 17050                 17055             


Thr Asn   Val Asn Ile Val Ala   Lys Ile Lys Gly Val   Pro Phe Pro 
    17060                 17065                 17070             


Thr Leu   Thr Trp Phe Lys Ala   Pro Pro Lys Lys Pro   Asp Asn Lys 
    17075                 17080                 17085             


Glu Pro   Val Leu Tyr Asp Thr   His Val Asn Lys Leu   Val Val Asp 
    17090                 17095                 17100             


Asp Thr   Cys Thr Leu Val Ile   Pro Gln Ser Arg Arg   Ser Asp Thr 
    17105                 17110                 17115             


Gly Leu   Tyr Thr Ile Thr Ala   Val Asn Asn Leu Gly   Thr Ala Ser 
    17120                 17125                 17130             


Lys Glu   Met Arg Leu Asn Val   Leu Gly Arg Pro Gly   Pro Pro Val 
    17135                 17140                 17145             


Gly Pro   Ile Lys Phe Glu Ser   Val Ser Ala Asp Gln   Met Thr Leu 
    17150                 17155                 17160             


Ser Trp   Phe Pro Pro Lys Asp   Asp Gly Gly Ser Lys   Ile Thr Asn 
    17165                 17170                 17175             


Tyr Val   Ile Glu Lys Arg Glu   Ala Asn Arg Lys Thr   Trp Val His 
    17180                 17185                 17190             


Val Ser   Ser Glu Pro Lys Glu   Cys Thr Tyr Thr Ile   Pro Lys Leu 
    17195                 17200                 17205             


Leu Glu   Gly His Glu Tyr Val   Phe Arg Ile Met Ala   Gln Asn Lys 
    17210                 17215                 17220             


Tyr Gly   Ile Gly Glu Pro Leu   Asp Ser Glu Pro Glu   Thr Ala Arg 
    17225                 17230                 17235             


Asn Leu   Phe Ser Val Pro Gly   Ala Pro Asp Lys Pro   Thr Val Ser 
    17240                 17245                 17250             


Ser Val   Thr Arg Asn Ser Met   Thr Val Asn Trp Glu   Glu Pro Glu 
    17255                 17260                 17265             


Tyr Asp   Gly Gly Ser Pro Val   Thr Gly Tyr Trp Leu   Glu Met Lys 
    17270                 17275                 17280             


Asp Thr   Thr Ser Lys Arg Trp   Lys Arg Val Asn Arg   Asp Pro Ile 
    17285                 17290                 17295             


Lys Ala   Met Thr Leu Gly Val   Ser Tyr Lys Val Thr   Gly Leu Ile 
    17300                 17305                 17310             


Glu Gly   Ser Asp Tyr Gln Phe   Arg Val Tyr Ala Ile   Asn Ala Ala 
    17315                 17320                 17325             


Gly Val   Gly Pro Ala Ser Leu   Pro Ser Asp Pro Ala   Thr Ala Arg 
    17330                 17335                 17340             


Asp Pro   Ile Ala Pro Pro Gly   Pro Pro Phe Pro Lys   Val Thr Asp 
    17345                 17350                 17355             


Trp Thr   Lys Ser Ser Ala Asp   Leu Glu Trp Ser Pro   Pro Leu Lys 
    17360                 17365                 17370             


Asp Gly   Gly Ser Lys Val Thr   Gly Tyr Ile Val Glu   Tyr Lys Glu 
    17375                 17380                 17385             


Glu Gly   Lys Glu Glu Trp Glu   Lys Gly Lys Asp Lys   Glu Val Arg 
    17390                 17395                 17400             


Gly Thr   Lys Leu Val Val Thr   Gly Leu Lys Glu Gly   Ala Phe Tyr 
    17405                 17410                 17415             


Lys Phe   Arg Val Arg Ala Val   Asn Ile Ala Gly Ile   Gly Glu Pro 
    17420                 17425                 17430             


Gly Glu   Val Thr Asp Val Ile   Glu Met Lys Asp Arg   Leu Val Ser 
    17435                 17440                 17445             


Pro Asp   Leu Gln Leu Asp Ala   Ser Val Arg Asp Arg   Ile Val Val 
    17450                 17455                 17460             


His Ala   Gly Gly Val Ile Arg   Ile Ile Ala Tyr Val   Ser Gly Lys 
    17465                 17470                 17475             


Pro Pro   Pro Thr Val Thr Trp   Asn Met Asn Glu Arg   Thr Leu Pro 
    17480                 17485                 17490             


Gln Glu   Ala Thr Ile Glu Thr   Thr Ala Ile Ser Ser   Ser Met Val 
    17495                 17500                 17505             


Ile Lys   Asn Cys Gln Arg Ser   His Gln Gly Val Tyr   Ser Leu Leu 
    17510                 17515                 17520             


Ala Lys   Asn Glu Ala Gly Glu   Arg Lys Lys Thr Ile   Ile Val Asp 
    17525                 17530                 17535             


Val Leu   Asp Val Pro Gly Pro   Val Gly Thr Pro Phe   Leu Ala His 
    17540                 17545                 17550             


Asn Leu   Thr Asn Glu Ser Cys   Lys Leu Thr Trp Phe   Ser Pro Glu 
    17555                 17560                 17565             


Asp Asp   Gly Gly Ser Pro Ile   Thr Asn Tyr Val Ile   Glu Lys Arg 
    17570                 17575                 17580             


Glu Ser   Asp Arg Arg Ala Trp   Thr Pro Val Thr Tyr   Thr Val Thr 
    17585                 17590                 17595             


Arg Gln   Asn Ala Thr Val Gln   Gly Leu Ile Gln Gly   Lys Ala Tyr 
    17600                 17605                 17610             


Phe Phe   Arg Ile Ala Ala Glu   Asn Ser Ile Gly Met   Gly Pro Phe 
    17615                 17620                 17625             


Val Glu   Thr Ser Glu Ala Leu   Val Ile Arg Glu Pro   Ile Thr Val 
    17630                 17635                 17640             


Pro Glu   Arg Pro Glu Asp Leu   Glu Val Lys Glu Val   Thr Lys Asn 
    17645                 17650                 17655             


Thr Val   Thr Leu Thr Trp Asn   Pro Pro Lys Tyr Asp   Gly Gly Ser 
    17660                 17665                 17670             


Glu Ile   Ile Asn Tyr Val Leu   Glu Ser Arg Leu Ile   Gly Thr Glu 
    17675                 17680                 17685             


Lys Phe   His Lys Val Thr Asn   Asp Asn Leu Leu Ser   Arg Lys Tyr 
    17690                 17695                 17700             


Thr Val   Lys Gly Leu Lys Glu   Gly Asp Thr Tyr Glu   Tyr Arg Val 
    17705                 17710                 17715             


Ser Ala   Val Asn Ile Val Gly   Gln Gly Lys Pro Ser   Phe Cys Thr 
    17720                 17725                 17730             


Lys Pro   Ile Thr Cys Lys Asp   Glu Leu Ala Pro Pro   Thr Leu His 
    17735                 17740                 17745             


Leu Asp   Phe Arg Asp Lys Leu   Thr Ile Arg Val Gly   Glu Ala Phe 
    17750                 17755                 17760             


Ala Leu   Thr Gly Arg Tyr Ser   Gly Lys Pro Lys Pro   Lys Val Ser 
    17765                 17770                 17775             


Trp Phe   Lys Asp Glu Ala Asp   Val Leu Glu Asp Asp   Arg Thr His 
    17780                 17785                 17790             


Ile Lys   Thr Thr Pro Ala Thr   Leu Ala Leu Glu Lys   Ile Lys Ala 
    17795                 17800                 17805             


Lys Arg   Ser Asp Ser Gly Lys   Tyr Cys Val Val Val   Glu Asn Ser 
    17810                 17815                 17820             


Thr Gly   Ser Arg Lys Gly Phe   Cys Gln Val Asn Val   Val Asp Arg 
    17825                 17830                 17835             


Pro Gly   Pro Pro Val Gly Pro   Val Ser Phe Asp Glu   Val Thr Lys 
    17840                 17845                 17850             


Asp Tyr   Met Val Ile Ser Trp   Lys Pro Pro Leu Asp   Asp Gly Gly 
    17855                 17860                 17865             


Ser Lys   Ile Thr Asn Tyr Ile   Ile Glu Lys Lys Glu   Val Gly Lys 
    17870                 17875                 17880             


Asp Val   Trp Met Pro Val Thr   Ser Ala Ser Ala Lys   Thr Thr Cys 
    17885                 17890                 17895             


Lys Val   Ser Lys Leu Leu Glu   Gly Lys Asp Tyr Ile   Phe Arg Ile 
    17900                 17905                 17910             


His Ala   Glu Asn Leu Tyr Gly   Ile Ser Asp Pro Leu   Val Ser Asp 
    17915                 17920                 17925             


Ser Met   Lys Ala Lys Asp Arg   Phe Arg Val Pro Asp   Ala Pro Asp 
    17930                 17935                 17940             


Gln Pro   Ile Val Thr Glu Val   Thr Lys Asp Ser Ala   Leu Val Thr 
    17945                 17950                 17955             


Trp Asn   Lys Pro His Asp Gly   Gly Lys Pro Ile Thr   Asn Tyr Ile 
    17960                 17965                 17970             


Leu Glu   Lys Arg Glu Thr Met   Ser Lys Arg Trp Ala   Arg Val Thr 
    17975                 17980                 17985             


Lys Asp   Pro Ile His Pro Tyr   Thr Lys Phe Arg Val   Pro Asp Leu 
    17990                 17995                 18000             


Leu Glu   Gly Cys Gln Tyr Glu   Phe Arg Val Ser Ala   Glu Asn Glu 
    18005                 18010                 18015             


Ile Gly   Ile Gly Asp Pro Ser   Pro Pro Ser Lys Pro   Val Phe Ala 
    18020                 18025                 18030             


Lys Asp   Pro Ile Ala Lys Pro   Ser Pro Pro Val Asn   Pro Glu Ala 
    18035                 18040                 18045             


Ile Asp   Thr Thr Cys Asn Ser   Val Asp Leu Thr Trp   Gln Pro Pro 
    18050                 18055                 18060             


Arg His   Asp Gly Gly Ser Lys   Ile Leu Gly Tyr Ile   Val Glu Tyr 
    18065                 18070                 18075             


Gln Lys   Val Gly Asp Glu Glu   Trp Arg Arg Ala Asn   His Thr Pro 
    18080                 18085                 18090             


Glu Ser   Cys Pro Glu Thr Lys   Tyr Lys Val Thr Gly   Leu Arg Asp 
    18095                 18100                 18105             


Gly Gln   Thr Tyr Lys Phe Arg   Val Leu Ala Val Asn   Ala Ala Gly 
    18110                 18115                 18120             


Glu Ser   Asp Pro Ala His Val   Pro Glu Pro Val Leu   Val Lys Asp 
    18125                 18130                 18135             


Arg Leu   Glu Pro Pro Glu Leu   Ile Leu Asp Ala Asn   Met Ala Arg 
    18140                 18145                 18150             


Glu Gln   His Ile Lys Val Gly   Asp Thr Leu Arg Leu   Ser Ala Ile 
    18155                 18160                 18165             


Ile Lys   Gly Val Pro Phe Pro   Lys Val Thr Trp Lys   Lys Glu Asp 
    18170                 18175                 18180             


Arg Asp   Ala Pro Thr Lys Ala   Arg Ile Asp Val Thr   Pro Val Gly 
    18185                 18190                 18195             


Ser Lys   Leu Glu Ile Arg Asn   Ala Ala His Glu Asp   Gly Gly Ile 
    18200                 18205                 18210             


Tyr Ser   Leu Thr Val Glu Asn   Pro Ala Gly Ser Lys   Thr Val Ser 
    18215                 18220                 18225             


Val Lys   Val Leu Val Leu Asp   Lys Pro Gly Pro Pro   Arg Asp Leu 
    18230                 18235                 18240             


Glu Val   Ser Glu Ile Arg Lys   Asp Ser Cys Tyr Leu   Thr Trp Lys 
    18245                 18250                 18255             


Glu Pro   Leu Asp Asp Gly Gly   Ser Val Ile Thr Asn   Tyr Val Val 
    18260                 18265                 18270             


Glu Arg   Arg Asp Val Ala Ser   Ala Gln Trp Ser Pro   Leu Ser Ala 
    18275                 18280                 18285             


Thr Ser   Lys Lys Lys Ser His   Phe Ala Lys His Leu   Asn Glu Gly 
    18290                 18295                 18300             


Asn Gln   Tyr Leu Phe Arg Val   Ala Ala Glu Asn Gln   Tyr Gly Arg 
    18305                 18310                 18315             


Gly Pro   Phe Val Glu Thr Pro   Lys Pro Ile Lys Ala   Leu Asp Pro 
    18320                 18325                 18330             


Leu His   Pro Pro Gly Pro Pro   Lys Asp Leu His His   Val Asp Val 
    18335                 18340                 18345             


Asp Lys   Thr Glu Val Ser Leu   Val Trp Asn Lys Pro   Asp Arg Asp 
    18350                 18355                 18360             


Gly Gly   Ser Pro Ile Thr Gly   Tyr Leu Val Glu Tyr   Gln Glu Glu 
    18365                 18370                 18375             


Gly Thr   Gln Asp Trp Ile Lys   Phe Lys Thr Val Thr   Asn Leu Glu 
    18380                 18385                 18390             


Cys Val   Val Thr Gly Leu Gln   Gln Gly Lys Thr Tyr   Arg Phe Arg 
    18395                 18400                 18405             


Val Lys   Ala Glu Asn Ile Val   Gly Leu Gly Leu Pro   Asp Thr Thr 
    18410                 18415                 18420             


Ile Pro   Ile Glu Cys Gln Glu   Lys Leu Val Pro Pro   Ser Val Glu 
    18425                 18430                 18435             


Leu Asp   Val Lys Leu Ile Glu   Gly Leu Val Val Lys   Ala Gly Thr 
    18440                 18445                 18450             


Thr Val   Arg Phe Pro Ala Ile   Ile Arg Gly Val Pro   Val Pro Thr 
    18455                 18460                 18465             


Ala Lys   Trp Thr Thr Asp Gly   Ser Glu Ile Lys Thr   Asp Glu His 
    18470                 18475                 18480             


Tyr Thr   Val Glu Thr Asp Asn   Phe Ser Ser Val Leu   Thr Ile Lys 
    18485                 18490                 18495             


Asn Cys   Leu Arg Arg Asp Thr   Gly Glu Tyr Gln Ile   Thr Val Ser 
    18500                 18505                 18510             


Asn Ala   Ala Gly Ser Lys Thr   Val Ala Val His Leu   Thr Val Leu 
    18515                 18520                 18525             


Asp Val   Pro Gly Pro Pro Thr   Gly Pro Ile Asn Ile   Leu Asp Val 
    18530                 18535                 18540             


Thr Pro   Glu His Met Thr Ile   Ser Trp Gln Pro Pro   Lys Asp Asp 
    18545                 18550                 18555             


Gly Gly   Ser Pro Val Ile Asn   Tyr Ile Val Glu Lys   Gln Asp Thr 
    18560                 18565                 18570             


Arg Lys   Asp Thr Trp Gly Val   Val Ser Ser Gly Ser   Ser Lys Thr 
    18575                 18580                 18585             


Lys Leu   Lys Ile Pro His Leu   Gln Lys Gly Cys Glu   Tyr Val Phe 
    18590                 18595                 18600             


Arg Val   Arg Ala Glu Asn Lys   Ile Gly Val Gly Pro   Pro Leu Asp 
    18605                 18610                 18615             


Ser Thr   Pro Thr Val Ala Lys   His Lys Phe Ser Pro   Pro Ser Pro 
    18620                 18625                 18630             


Pro Gly   Lys Pro Val Val Thr   Asp Ile Thr Glu Asn   Ala Ala Thr 
    18635                 18640                 18645             


Val Ser   Trp Thr Leu Pro Lys   Ser Asp Gly Gly Ser   Pro Ile Thr 
    18650                 18655                 18660             


Gly Tyr   Tyr Met Glu Arg Arg   Glu Val Thr Gly Lys   Trp Val Arg 
    18665                 18670                 18675             


Val Asn   Lys Thr Pro Ile Ala   Asp Leu Lys Phe Arg   Val Thr Gly 
    18680                 18685                 18690             


Leu Tyr   Glu Gly Asn Thr Tyr   Glu Phe Arg Val Phe   Ala Glu Asn 
    18695                 18700                 18705             


Leu Ala   Gly Leu Ser Lys Pro   Ser Pro Ser Ser Asp   Pro Ile Lys 
    18710                 18715                 18720             


Ala Cys   Arg Pro Ile Lys Pro   Pro Gly Pro Pro Ile   Asn Pro Lys 
    18725                 18730                 18735             


Leu Lys   Asp Lys Ser Arg Glu   Thr Ala Asp Leu Val   Trp Thr Lys 
    18740                 18745                 18750             


Pro Leu   Ser Asp Gly Gly Ser   Pro Ile Leu Gly Tyr   Val Val Glu 
    18755                 18760                 18765             


Cys Gln   Lys Pro Gly Thr Ala   Gln Trp Asn Arg Ile   Asn Lys Asp 
    18770                 18775                 18780             


Glu Leu   Ile Arg Gln Cys Ala   Phe Arg Val Pro Gly   Leu Ile Glu 
    18785                 18790                 18795             


Gly Asn   Glu Tyr Arg Phe Arg   Ile Lys Ala Ala Asn   Ile Val Gly 
    18800                 18805                 18810             


Glu Gly   Glu Pro Arg Glu Leu   Ala Glu Ser Val Ile   Ala Lys Asp 
    18815                 18820                 18825             


Ile Leu   His Pro Pro Glu Val   Glu Leu Asp Val Thr   Cys Arg Asp 
    18830                 18835                 18840             


Val Ile   Thr Val Arg Val Gly   Gln Thr Ile Arg Ile   Leu Ala Arg 
    18845                 18850                 18855             


Val Lys   Gly Arg Pro Glu Pro   Asp Ile Thr Trp Thr   Lys Glu Gly 
    18860                 18865                 18870             


Lys Val   Leu Val Arg Glu Lys   Arg Val Asp Leu Ile   Gln Asp Leu 
    18875                 18880                 18885             


Pro Arg   Val Glu Leu Gln Ile   Lys Glu Ala Val Arg   Ala Asp His 
    18890                 18895                 18900             


Gly Lys   Tyr Ile Ile Ser Ala   Lys Asn Ser Ser Gly   His Ala Gln 
    18905                 18910                 18915             


Gly Ser   Ala Ile Val Asn Val   Leu Asp Arg Pro Gly   Pro Cys Gln 
    18920                 18925                 18930             


Asn Leu   Lys Val Thr Asn Val   Thr Lys Glu Asn Cys   Thr Ile Ser 
    18935                 18940                 18945             


Trp Glu   Asn Pro Leu Asp Asn   Gly Gly Ser Glu Ile   Thr Asn Phe 
    18950                 18955                 18960             


Ile Val   Glu Tyr Arg Lys Pro   Asn Gln Lys Gly Trp   Ser Ile Val 
    18965                 18970                 18975             


Ala Ser   Asp Val Thr Lys Arg   Leu Ile Lys Ala Asn   Leu Leu Ala 
    18980                 18985                 18990             


Asn Asn   Glu Tyr Tyr Phe Arg   Val Cys Ala Glu Asn   Lys Val Gly 
    18995                 19000                 19005             


Val Gly   Pro Thr Ile Glu Thr   Lys Thr Pro Ile Leu   Ala Ile Asn 
    19010                 19015                 19020             


Pro Ile   Asp Arg Pro Gly Glu   Pro Glu Asn Leu His   Ile Ala Asp 
    19025                 19030                 19035             


Lys Gly   Lys Thr Phe Val Tyr   Leu Lys Trp Arg Arg   Pro Asp Tyr 
    19040                 19045                 19050             


Asp Gly   Gly Ser Pro Asn Leu   Ser Tyr His Val Glu   Arg Arg Leu 
    19055                 19060                 19065             


Lys Gly   Ser Asp Asp Trp Glu   Arg Val His Lys Gly   Ser Ile Lys 
    19070                 19075                 19080             


Glu Thr   His Tyr Met Val Asp   Arg Cys Val Glu Asn   Gln Ile Tyr 
    19085                 19090                 19095             


Glu Phe   Arg Val Gln Thr Lys   Asn Glu Gly Gly Glu   Ser Asp Trp 
    19100                 19105                 19110             


Val Lys   Thr Glu Glu Val Val   Val Lys Glu Asp Leu   Gln Lys Pro 
    19115                 19120                 19125             


Val Leu   Asp Leu Lys Leu Ser   Gly Val Leu Thr Val   Lys Ala Gly 
    19130                 19135                 19140             


Asp Thr   Ile Arg Leu Glu Ala   Gly Val Arg Gly Lys   Pro Phe Pro 
    19145                 19150                 19155             


Glu Val   Ala Trp Thr Lys Asp   Lys Asp Ala Thr Asp   Leu Thr Arg 
    19160                 19165                 19170             


Ser Pro   Arg Val Lys Ile Asp   Thr Arg Ala Asp Ser   Ser Lys Phe 
    19175                 19180                 19185             


Ser Leu   Thr Lys Ala Lys Arg   Ser Asp Gly Gly Lys   Tyr Val Val 
    19190                 19195                 19200             


Thr Ala   Thr Asn Thr Ala Gly   Ser Phe Val Ala Tyr   Ala Thr Val 
    19205                 19210                 19215             


Asn Val   Leu Asp Lys Pro Gly   Pro Val Arg Asn Leu   Lys Ile Val 
    19220                 19225                 19230             


Asp Val   Ser Ser Asp Arg Cys   Thr Val Cys Trp Asp   Pro Pro Glu 
    19235                 19240                 19245             


Asp Asp   Gly Gly Cys Glu Ile   Gln Asn Tyr Ile Leu   Glu Lys Cys 
    19250                 19255                 19260             


Glu Thr   Lys Arg Met Val Trp   Ser Thr Tyr Ser Ala   Thr Val Leu 
    19265                 19270                 19275             


Thr Pro   Gly Thr Thr Val Thr   Arg Leu Ile Glu Gly   Asn Glu Tyr 
    19280                 19285                 19290             


Ile Phe   Arg Val Arg Ala Glu   Asn Lys Ile Gly Thr   Gly Pro Pro 
    19295                 19300                 19305             


Thr Glu   Ser Lys Pro Val Ile   Ala Lys Thr Lys Tyr   Asp Lys Pro 
    19310                 19315                 19320             


Gly Arg   Pro Asp Pro Pro Glu   Val Thr Lys Val Ser   Lys Glu Glu 
    19325                 19330                 19335             


Met Thr   Val Val Trp Asn Pro   Pro Glu Tyr Asp Gly   Gly Lys Ser 
    19340                 19345                 19350             


Ile Thr   Gly Tyr Phe Leu Glu   Lys Lys Glu Lys His   Ser Thr Arg 
    19355                 19360                 19365             


Trp Val   Pro Val Asn Lys Ser   Ala Ile Pro Glu Arg   Arg Met Lys 
    19370                 19375                 19380             


Val Gln   Asn Leu Leu Pro Asp   His Glu Tyr Gln Phe   Arg Val Lys 
    19385                 19390                 19395             


Ala Glu   Asn Glu Ile Gly Ile   Gly Glu Pro Ser Leu   Pro Ser Arg 
    19400                 19405                 19410             


Pro Val   Val Ala Lys Asp Pro   Ile Glu Pro Pro Gly   Pro Pro Thr 
    19415                 19420                 19425             


Asn Phe   Arg Val Val Asp Thr   Thr Lys His Ser Ile   Thr Leu Gly 
    19430                 19435                 19440             


Trp Gly   Lys Pro Val Tyr Asp   Gly Gly Ala Pro Ile   Ile Gly Tyr 
    19445                 19450                 19455             


Val Val   Glu Met Arg Pro Lys   Ile Ala Asp Ala Ser   Pro Asp Glu 
    19460                 19465                 19470             


Gly Trp   Lys Arg Cys Asn Ala   Ala Ala Gln Leu Val   Arg Lys Glu 
    19475                 19480                 19485             


Phe Thr   Val Thr Ser Leu Asp   Glu Asn Gln Glu Tyr   Glu Phe Arg 
    19490                 19495                 19500             


Val Cys   Ala Gln Asn Gln Val   Gly Ile Gly Arg Pro   Ala Glu Leu 
    19505                 19510                 19515             


Lys Glu   Ala Ile Lys Pro Lys   Glu Ile Leu Glu Pro   Pro Glu Ile 
    19520                 19525                 19530             


Asp Leu   Asp Ala Ser Met Arg   Lys Leu Val Ile Val   Arg Ala Gly 
    19535                 19540                 19545             


Cys Pro   Ile Arg Leu Phe Ala   Ile Val Arg Gly Arg   Pro Ala Pro 
    19550                 19555                 19560             


Lys Val   Thr Trp Arg Lys Val   Gly Ile Asp Asn Val   Val Arg Lys 
    19565                 19570                 19575             


Gly Gln   Val Asp Leu Val Asp   Thr Met Ala Phe Leu   Val Ile Pro 
    19580                 19585                 19590             


Asn Ser   Thr Arg Asp Asp Ser   Gly Lys Tyr Ser Leu   Thr Leu Val 
    19595                 19600                 19605             


Asn Pro   Ala Gly Glu Lys Ala   Val Phe Val Asn Val   Arg Val Leu 
    19610                 19615                 19620             


Asp Thr   Pro Gly Pro Val Ser   Asp Leu Lys Val Ser   Asp Val Thr 
    19625                 19630                 19635             


Lys Thr   Ser Cys His Val Ser   Trp Ala Pro Pro Glu   Asn Asp Gly 
    19640                 19645                 19650             


Gly Ser   Gln Val Thr His Tyr   Ile Val Glu Lys Arg   Glu Ala Asp 
    19655                 19660                 19665             


Arg Lys   Thr Trp Ser Thr Val   Thr Pro Glu Val Lys   Lys Thr Ser 
    19670                 19675                 19680             


Phe His   Val Thr Asn Leu Val   Pro Gly Asn Glu Tyr   Tyr Phe Arg 
    19685                 19690                 19695             


Val Thr   Ala Val Asn Glu Tyr   Gly Pro Gly Val Pro   Thr Asp Val 
    19700                 19705                 19710             


Pro Lys   Pro Val Leu Ala Ser   Asp Pro Leu Ser Glu   Pro Asp Pro 
    19715                 19720                 19725             


Pro Arg   Lys Leu Glu Val Thr   Glu Met Thr Lys Asn   Ser Ala Thr 
    19730                 19735                 19740             


Leu Ala   Trp Leu Pro Pro Leu   Arg Asp Gly Gly Ala   Lys Ile Asp 
    19745                 19750                 19755             


Gly Tyr   Ile Thr Ser Tyr Arg   Glu Glu Glu Gln Pro   Ala Asp Arg 
    19760                 19765                 19770             


Trp Thr   Glu Tyr Ser Val Val   Lys Asp Leu Ser Leu   Val Val Thr 
    19775                 19780                 19785             


Gly Leu   Lys Glu Gly Lys Lys   Tyr Lys Phe Arg Val   Ala Ala Arg 
    19790                 19795                 19800             


Asn Ala   Val Gly Val Ser Leu   Pro Arg Glu Ala Glu   Gly Val Tyr 
    19805                 19810                 19815             


Glu Ala   Lys Glu Gln Leu Leu   Pro Pro Lys Ile Leu   Met Pro Glu 
    19820                 19825                 19830             


Gln Ile   Thr Ile Lys Ala Gly   Lys Lys Leu Arg Ile   Glu Ala His 
    19835                 19840                 19845             


Val Tyr   Gly Lys Pro His Pro   Thr Cys Lys Trp Lys   Lys Gly Glu 
    19850                 19855                 19860             


Asp Glu   Val Val Thr Ser Ser   His Leu Ala Val His   Lys Ala Asp 
    19865                 19870                 19875             


Ser Ser   Ser Ile Leu Ile Ile   Lys Asp Val Thr Arg   Lys Asp Ser 
    19880                 19885                 19890             


Gly Tyr   Tyr Ser Leu Thr Ala   Glu Asn Ser Ser Gly   Thr Asp Thr 
    19895                 19900                 19905             


Gln Lys   Ile Lys Val Val Val   Met Asp Ala Pro Gly   Pro Pro Gln 
    19910                 19915                 19920             


Pro Pro   Phe Asp Ile Ser Asp   Ile Asp Ala Asp Ala   Cys Ser Leu 
    19925                 19930                 19935             


Ser Trp   His Ile Pro Leu Glu   Asp Gly Gly Ser Asn   Ile Thr Asn 
    19940                 19945                 19950             


Tyr Ile   Val Glu Lys Cys Asp   Val Ser Arg Gly Asp   Trp Val Thr 
    19955                 19960                 19965             


Ala Leu   Ala Ser Val Thr Lys   Thr Ser Cys Arg Val   Gly Lys Leu 
    19970                 19975                 19980             


Ile Pro   Gly Gln Glu Tyr Ile   Phe Arg Val Arg Ala   Glu Asn Arg 
    19985                 19990                 19995             


Phe Gly   Ile Ser Glu Pro Leu   Thr Ser Pro Lys Met   Val Ala Gln 
    20000                 20005                 20010             


Phe Pro   Phe Gly Val Pro Ser   Glu Pro Lys Asn Ala   Arg Val Thr 
    20015                 20020                 20025             


Lys Val   Asn Lys Asp Cys Ile   Phe Val Ala Trp Asp   Arg Pro Asp 
    20030                 20035                 20040             


Ser Asp   Gly Gly Ser Pro Ile   Ile Gly Tyr Leu Ile   Glu Arg Lys 
    20045                 20050                 20055             


Glu Arg   Asn Ser Leu Leu Trp   Val Lys Ala Asn Asp   Thr Leu Val 
    20060                 20065                 20070             


Arg Ser   Thr Glu Tyr Pro Cys   Ala Gly Leu Val Glu   Gly Leu Glu 
    20075                 20080                 20085             


Tyr Ser   Phe Arg Ile Tyr Ala   Leu Asn Lys Ala Gly   Ser Ser Pro 
    20090                 20095                 20100             


Pro Ser   Lys Pro Thr Glu Tyr   Val Thr Ala Arg Met   Pro Val Asp 
    20105                 20110                 20115             


Pro Pro   Gly Lys Pro Glu Val   Ile Asp Val Thr Lys   Ser Thr Val 
    20120                 20125                 20130             


Ser Leu   Ile Trp Ala Arg Pro   Lys His Asp Gly Gly   Ser Lys Ile 
    20135                 20140                 20145             


Ile Gly   Tyr Phe Val Glu Ala   Cys Lys Leu Pro Gly   Asp Lys Trp 
    20150                 20155                 20160             


Val Arg   Cys Asn Thr Ala Pro   His Gln Ile Pro Gln   Glu Glu Tyr 
    20165                 20170                 20175             


Thr Ala   Thr Gly Leu Glu Glu   Lys Ala Gln Tyr Gln   Phe Arg Ala 
    20180                 20185                 20190             


Ile Ala   Arg Thr Ala Val Asn   Ile Ser Pro Pro Ser   Glu Pro Ser 
    20195                 20200                 20205             


Asp Pro   Val Thr Ile Leu Ala   Glu Asn Val Pro Pro   Arg Ile Asp 
    20210                 20215                 20220             


Leu Ser   Val Ala Met Lys Ser   Leu Leu Thr Val Lys   Ala Gly Thr 
    20225                 20230                 20235             


Asn Val   Cys Leu Asp Ala Thr   Val Phe Gly Lys Pro   Met Pro Thr 
    20240                 20245                 20250             


Val Ser   Trp Lys Lys Asp Gly   Thr Leu Leu Lys Pro   Ala Glu Gly 
    20255                 20260                 20265             


Ile Lys   Met Ala Met Gln Arg   Asn Leu Cys Thr Leu   Glu Leu Phe 
    20270                 20275                 20280             


Ser Val   Asn Arg Lys Asp Ser   Gly Asp Tyr Thr Ile   Thr Ala Glu 
    20285                 20290                 20295             


Asn Ser   Ser Gly Ser Lys Ser   Ala Thr Ile Lys Leu   Lys Val Leu 
    20300                 20305                 20310             


Asp Lys   Pro Gly Pro Pro Ala   Ser Val Lys Ile Asn   Lys Met Tyr 
    20315                 20320                 20325             


Ser Asp   Arg Ala Met Leu Ser   Trp Glu Pro Pro Leu   Glu Asp Gly 
    20330                 20335                 20340             


Gly Ser   Glu Ile Thr Asn Tyr   Ile Val Asp Lys Arg   Glu Thr Ser 
    20345                 20350                 20355             


Arg Pro   Asn Trp Ala Gln Val   Ser Ala Thr Val Pro   Ile Thr Ser 
    20360                 20365                 20370             


Cys Ser   Val Glu Lys Leu Ile   Glu Gly His Glu Tyr   Gln Phe Arg 
    20375                 20380                 20385             


Ile Cys   Ala Glu Asn Lys Tyr   Gly Val Gly Asp Pro   Val Phe Thr 
    20390                 20395                 20400             


Glu Pro   Ala Ile Ala Lys Asn   Pro Tyr Asp Pro Pro   Gly Arg Cys 
    20405                 20410                 20415             


Asp Pro   Pro Val Ile Ser Asn   Ile Thr Lys Asp His   Met Thr Val 
    20420                 20425                 20430             


Ser Trp   Lys Pro Pro Ala Asp   Asp Gly Gly Ser Pro   Ile Thr Gly 
    20435                 20440                 20445             


Tyr Leu   Leu Glu Lys Arg Glu   Thr Gln Ala Val Asn   Trp Thr Lys 
    20450                 20455                 20460             


Val Asn   Arg Lys Pro Ile Ile   Glu Arg Thr Leu Lys   Ala Thr Gly 
    20465                 20470                 20475             


Leu Gln   Glu Gly Thr Glu Tyr   Glu Phe Arg Val Thr   Ala Ile Asn 
    20480                 20485                 20490             


Lys Ala   Gly Pro Gly Lys Pro   Ser Asp Ala Ser Lys   Ala Ala Tyr 
    20495                 20500                 20505             


Ala Arg   Asp Pro Gln Tyr Pro   Pro Gly Pro Pro Ala   Phe Pro Lys 
    20510                 20515                 20520             


Val Tyr   Asp Thr Thr Arg Ser   Ser Val Ser Leu Ser   Trp Gly Lys 
    20525                 20530                 20535             


Pro Ala   Tyr Asp Gly Gly Ser   Pro Ile Ile Gly Tyr   Leu Val Glu 
    20540                 20545                 20550             


Val Lys   Arg Ala Asp Ser Asp   Asn Trp Val Arg Cys   Asn Leu Pro 
    20555                 20560                 20565             


Gln Asn   Leu Gln Lys Thr Arg   Phe Glu Val Thr Gly   Leu Met Glu 
    20570                 20575                 20580             


Asp Thr   Gln Tyr Gln Phe Arg   Val Tyr Ala Val Asn   Lys Ile Gly 
    20585                 20590                 20595             


Tyr Ser   Asp Pro Ser Asp Val   Pro Asp Lys His Tyr   Pro Lys Asp 
    20600                 20605                 20610             


Ile Leu   Ile Pro Pro Glu Gly   Glu Leu Asp Ala Asp   Leu Arg Lys 
    20615                 20620                 20625             


Thr Leu   Ile Leu Arg Ala Gly   Val Thr Met Arg Leu   Tyr Val Pro 
    20630                 20635                 20640             


Val Lys   Gly Arg Pro Pro Pro   Lys Ile Thr Trp Ser   Lys Pro Asn 
    20645                 20650                 20655             


Val Asn   Leu Arg Asp Arg Ile   Gly Leu Asp Ile Lys   Ser Thr Asp 
    20660                 20665                 20670             


Phe Asp   Thr Phe Leu Arg Cys   Glu Asn Val Asn Lys   Tyr Asp Ala 
    20675                 20680                 20685             


Gly Lys   Tyr Ile Leu Thr Leu   Glu Asn Ser Cys Gly   Lys Lys Glu 
    20690                 20695                 20700             


Tyr Thr   Ile Val Val Lys Val   Leu Asp Thr Pro Gly   Pro Pro Val 
    20705                 20710                 20715             


Asn Val   Thr Val Lys Glu Ile   Ser Lys Asp Ser Ala   Tyr Val Thr 
    20720                 20725                 20730             


Trp Glu   Pro Pro Ile Ile Asp   Gly Gly Ser Pro Ile   Ile Asn Tyr 
    20735                 20740                 20745             


Val Val   Gln Lys Arg Asp Ala   Glu Arg Lys Ser Trp   Ser Thr Val 
    20750                 20755                 20760             


Thr Thr   Glu Cys Ser Lys Thr   Ser Phe Arg Val Ala   Asn Leu Glu 
    20765                 20770                 20775             


Glu Gly   Lys Ser Tyr Phe Phe   Arg Val Phe Ala Glu   Asn Glu Tyr 
    20780                 20785                 20790             


Gly Ile   Gly Asp Pro Gly Glu   Thr Arg Asp Ala Val   Lys Ala Ser 
    20795                 20800                 20805             


Gln Thr   Pro Gly Pro Val Val   Asp Leu Lys Val Arg   Ser Val Ser 
    20810                 20815                 20820             


Lys Ser   Ser Cys Ser Ile Gly   Trp Lys Lys Pro His   Ser Asp Gly 
    20825                 20830                 20835             


Gly Ser   Arg Ile Ile Gly Tyr   Val Val Asp Phe Leu   Thr Glu Glu 
    20840                 20845                 20850             


Asn Lys   Trp Gln Arg Val Met   Lys Ser Leu Ser Leu   Gln Tyr Ser 
    20855                 20860                 20865             


Ala Lys   Asp Leu Thr Glu Gly   Lys Glu Tyr Thr Phe   Arg Val Ser 
    20870                 20875                 20880             


Ala Glu   Asn Glu Asn Gly Glu   Gly Thr Pro Ser Glu   Ile Thr Val 
    20885                 20890                 20895             


Val Ala   Arg Asp Asp Val Val   Ala Pro Asp Leu Asp   Leu Lys Gly 
    20900                 20905                 20910             


Leu Pro   Asp Leu Cys Tyr Leu   Ala Lys Glu Asn Ser   Asn Phe Arg 
    20915                 20920                 20925             


Leu Lys   Ile Pro Ile Lys Gly   Lys Pro Ala Pro Ser   Val Ser Trp 
    20930                 20935                 20940             


Lys Lys   Gly Glu Asp Pro Leu   Ala Thr Asp Thr Arg   Val Ser Val 
    20945                 20950                 20955             


Glu Ser   Ser Ala Val Asn Thr   Thr Leu Ile Val Tyr   Asp Cys Gln 
    20960                 20965                 20970             


Lys Ser   Asp Ala Gly Lys Tyr   Thr Ile Thr Leu Lys   Asn Val Ala 
    20975                 20980                 20985             


Gly Thr   Lys Glu Gly Thr Ile   Ser Ile Lys Val Val   Gly Lys Pro 
    20990                 20995                 21000             


Gly Ile   Pro Thr Gly Pro Ile   Lys Phe Asp Glu Val   Thr Ala Glu 
    21005                 21010                 21015             


Ala Met   Thr Leu Lys Trp Ala   Pro Pro Lys Asp Asp   Gly Gly Ser 
    21020                 21025                 21030             


Glu Ile   Thr Asn Tyr Ile Leu   Glu Lys Arg Asp Ser   Val Asn Asn 
    21035                 21040                 21045             


Lys Trp   Val Thr Cys Ala Ser   Ala Val Gln Lys Thr   Thr Phe Arg 
    21050                 21055                 21060             


Val Thr   Arg Leu His Glu Gly   Met Glu Tyr Thr Phe   Arg Val Ser 
    21065                 21070                 21075             


Ala Glu   Asn Lys Tyr Gly Val   Gly Glu Gly Leu Lys   Ser Glu Pro 
    21080                 21085                 21090             


Ile Val   Ala Arg His Pro Phe   Asp Val Pro Asp Ala   Pro Pro Pro 
    21095                 21100                 21105             


Pro Asn   Ile Val Asp Val Arg   His Asp Ser Val Ser   Leu Thr Trp 
    21110                 21115                 21120             


Thr Asp   Pro Lys Lys Thr Gly   Gly Ser Pro Ile Thr   Gly Tyr His 
    21125                 21130                 21135             


Leu Glu   Phe Lys Glu Arg Asn   Ser Leu Leu Trp Lys   Arg Ala Asn 
    21140                 21145                 21150             


Lys Thr   Pro Ile Arg Met Arg   Asp Phe Lys Val Thr   Gly Leu Thr 
    21155                 21160                 21165             


Glu Gly   Leu Glu Tyr Glu Phe   Arg Val Met Ala Ile   Asn Leu Ala 
    21170                 21175                 21180             


Gly Val   Gly Lys Pro Ser Leu   Pro Ser Glu Pro Val   Val Ala Leu 
    21185                 21190                 21195             


Asp Pro   Ile Asp Pro Pro Gly   Lys Pro Glu Val Ile   Asn Ile Thr 
    21200                 21205                 21210             


Arg Asn   Ser Val Thr Leu Ile   Trp Thr Glu Pro Lys   Tyr Asp Gly 
    21215                 21220                 21225             


Gly His   Lys Leu Thr Gly Tyr   Ile Val Glu Lys Arg   Asp Leu Pro 
    21230                 21235                 21240             


Ser Lys   Ser Trp Met Lys Ala   Asn His Val Asn Val   Pro Glu Cys 
    21245                 21250                 21255             


Ala Phe   Thr Val Thr Asp Leu   Val Glu Gly Gly Lys   Tyr Glu Phe 
    21260                 21265                 21270             


Arg Ile   Arg Ala Lys Asn Thr   Ala Gly Ala Ile Ser   Ala Pro Ser 
    21275                 21280                 21285             


Glu Ser   Thr Glu Thr Ile Ile   Cys Lys Asp Glu Tyr   Glu Ala Pro 
    21290                 21295                 21300             


Thr Ile   Val Leu Asp Pro Thr   Ile Lys Asp Gly Leu   Thr Ile Lys 
    21305                 21310                 21315             


Ala Gly   Asp Thr Ile Val Leu   Asn Ala Ile Ser Ile   Leu Gly Lys 
    21320                 21325                 21330             


Pro Leu   Pro Lys Ser Ser Trp   Ser Lys Ala Gly Lys   Asp Ile Arg 
    21335                 21340                 21345             


Pro Ser   Asp Ile Thr Gln Ile   Thr Ser Thr Pro Thr   Ser Ser Met 
    21350                 21355                 21360             


Leu Thr   Ile Lys Tyr Ala Thr   Arg Lys Asp Ala Gly   Glu Tyr Thr 
    21365                 21370                 21375             


Ile Thr   Ala Thr Asn Pro Phe   Gly Thr Lys Val Glu   His Val Lys 
    21380                 21385                 21390             


Val Thr   Val Leu Asp Val Pro   Gly Pro Pro Gly Pro   Val Glu Ile 
    21395                 21400                 21405             


Ser Asn   Val Ser Ala Glu Lys   Ala Thr Leu Thr Trp   Thr Pro Pro 
    21410                 21415                 21420             


Leu Glu   Asp Gly Gly Ser Pro   Ile Lys Ser Tyr Ile   Leu Glu Lys 
    21425                 21430                 21435             


Arg Glu   Thr Ser Arg Leu Leu   Trp Thr Val Val Ser   Glu Asp Ile 
    21440                 21445                 21450             


Gln Ser   Cys Arg His Val Ala   Thr Lys Leu Ile Gln   Gly Asn Glu 
    21455                 21460                 21465             


Tyr Ile   Phe Arg Val Ser Ala   Val Asn His Tyr Gly   Lys Gly Glu 
    21470                 21475                 21480             


Pro Val   Gln Ser Glu Pro Val   Lys Met Val Asp Arg   Phe Gly Pro 
    21485                 21490                 21495             


Pro Gly   Pro Pro Glu Lys Pro   Glu Val Ser Asn Val   Thr Lys Asn 
    21500                 21505                 21510             


Thr Ala   Thr Val Ser Trp Lys   Arg Pro Val Asp Asp   Gly Gly Ser 
    21515                 21520                 21525             


Glu Ile   Thr Gly Tyr His Val   Glu Arg Arg Glu Lys   Lys Ser Leu 
    21530                 21535                 21540             


Arg Trp   Val Arg Ala Ile Lys   Thr Pro Val Ser Asp   Leu Arg Cys 
    21545                 21550                 21555             


Lys Val   Thr Gly Leu Gln Glu   Gly Ser Thr Tyr Glu   Phe Arg Val 
    21560                 21565                 21570             


Ser Ala   Glu Asn Arg Ala Gly   Ile Gly Pro Pro Ser   Glu Ala Ser 
    21575                 21580                 21585             


Asp Ser   Val Leu Met Lys Asp   Ala Ala Tyr Pro Pro   Gly Pro Pro 
    21590                 21595                 21600             


Ser Asn   Pro His Val Thr Asp   Thr Thr Lys Lys Ser   Ala Ser Leu 
    21605                 21610                 21615             


Ala Trp   Gly Lys Pro His Tyr   Asp Gly Gly Leu Glu   Ile Thr Gly 
    21620                 21625                 21630             


Tyr Val   Val Glu His Gln Lys   Val Gly Asp Glu Ala   Trp Ile Lys 
    21635                 21640                 21645             


Asp Thr   Thr Gly Thr Ala Leu   Arg Ile Thr Gln Phe   Val Val Pro 
    21650                 21655                 21660             


Asp Leu   Gln Thr Lys Glu Lys   Tyr Asn Phe Arg Ile   Ser Ala Ile 
    21665                 21670                 21675             


Asn Asp   Ala Gly Val Gly Glu   Pro Ala Val Ile Pro   Asp Val Glu 
    21680                 21685                 21690             


Ile Val   Glu Arg Glu Met Ala   Pro Asp Phe Glu Leu   Asp Ala Glu 
    21695                 21700                 21705             


Leu Arg   Arg Thr Leu Val Val   Arg Ala Gly Leu Ser   Ile Arg Ile 
    21710                 21715                 21720             


Phe Val   Pro Ile Lys Gly Arg   Pro Ala Pro Glu Val   Thr Trp Thr 
    21725                 21730                 21735             


Lys Asp   Asn Ile Asn Leu Lys   Asn Arg Ala Asn Ile   Glu Asn Thr 
    21740                 21745                 21750             


Glu Ser   Phe Thr Leu Leu Ile   Ile Pro Glu Cys Asn   Arg Tyr Asp 
    21755                 21760                 21765             


Thr Gly   Lys Phe Val Met Thr   Ile Glu Asn Pro Ala   Gly Lys Lys 
    21770                 21775                 21780             


Ser Gly   Phe Val Asn Val Arg   Val Leu Asp Thr Pro   Gly Pro Val 
    21785                 21790                 21795             


Leu Asn   Leu Arg Pro Thr Asp   Ile Thr Lys Asp Ser   Val Thr Leu 
    21800                 21805                 21810             


His Trp   Asp Leu Pro Leu Ile   Asp Gly Gly Ser Arg   Ile Thr Asn 
    21815                 21820                 21825             


Tyr Ile   Val Glu Lys Arg Glu   Ala Thr Arg Lys Ser   Tyr Ser Thr 
    21830                 21835                 21840             


Ala Thr   Thr Lys Cys His Lys   Cys Thr Tyr Lys Val   Thr Gly Leu 
    21845                 21850                 21855             


Ser Glu   Gly Cys Glu Tyr Phe   Phe Arg Val Met Ala   Glu Asn Glu 
    21860                 21865                 21870             


Tyr Gly   Ile Gly Glu Pro Thr   Glu Thr Thr Glu Pro   Val Lys Ala 
    21875                 21880                 21885             


Ser Glu   Ala Pro Ser Pro Pro   Asp Ser Leu Asn Ile   Met Asp Ile 
    21890                 21895                 21900             


Thr Lys   Ser Thr Val Ser Leu   Ala Trp Pro Lys Pro   Lys His Asp 
    21905                 21910                 21915             


Gly Gly   Ser Lys Ile Thr Gly   Tyr Val Ile Glu Ala   Gln Arg Lys 
    21920                 21925                 21930             


Gly Ser   Asp Gln Trp Thr His   Ile Thr Thr Val Lys   Gly Leu Glu 
    21935                 21940                 21945             


Cys Val   Val Arg Asn Leu Thr   Glu Gly Glu Glu Tyr   Thr Phe Gln 
    21950                 21955                 21960             


Val Met   Ala Val Asn Ser Ala   Gly Arg Ser Ala Pro   Arg Glu Ser 
    21965                 21970                 21975             


Arg Pro   Val Ile Val Lys Glu   Gln Thr Met Leu Pro   Glu Leu Asp 
    21980                 21985                 21990             


Leu Arg   Gly Ile Tyr Gln Lys   Leu Val Ile Ala Lys   Ala Gly Asp 
    21995                 22000                 22005             


Asn Ile   Lys Val Glu Ile Pro   Val Leu Gly Arg Pro   Lys Pro Thr 
    22010                 22015                 22020             


Val Thr   Trp Lys Lys Gly Asp   Gln Ile Leu Lys Gln   Thr Gln Arg 
    22025                 22030                 22035             


Val Asn   Phe Glu Thr Thr Ala   Thr Ser Thr Ile Leu   Asn Ile Asn 
    22040                 22045                 22050             


Glu Cys   Val Arg Ser Asp Ser   Gly Pro Tyr Pro Leu   Thr Ala Arg 
    22055                 22060                 22065             


Asn Ile   Val Gly Glu Val Gly   Asp Val Ile Thr Ile   Gln Val His 
    22070                 22075                 22080             


Asp Ile   Pro Gly Pro Pro Thr   Gly Pro Ile Lys Phe   Asp Glu Val 
    22085                 22090                 22095             


Ser Ser   Asp Phe Val Thr Phe   Ser Trp Asp Pro Pro   Glu Asn Asp 
    22100                 22105                 22110             


Gly Gly   Val Pro Ile Ser Asn   Tyr Val Val Glu Met   Arg Gln Thr 
    22115                 22120                 22125             


Asp Ser   Thr Thr Trp Val Glu   Leu Ala Thr Thr Val   Ile Arg Thr 
    22130                 22135                 22140             


Thr Tyr   Lys Ala Thr Arg Leu   Thr Thr Gly Leu Glu   Tyr Gln Phe 
    22145                 22150                 22155             


Arg Val   Lys Ala Gln Asn Arg   Tyr Gly Val Gly Pro   Gly Ile Thr 
    22160                 22165                 22170             


Ser Ala   Cys Ile Val Ala Asn   Tyr Pro Phe Lys Val   Pro Gly Pro 
    22175                 22180                 22185             


Pro Gly   Thr Pro Gln Val Thr   Ala Val Thr Lys Asp   Ser Met Thr 
    22190                 22195                 22200             


Ile Ser   Trp His Glu Pro Leu   Ser Asp Gly Gly Ser   Pro Ile Leu 
    22205                 22210                 22215             


Gly Tyr   His Val Glu Arg Lys   Glu Arg Asn Gly Ile   Leu Trp Gln 
    22220                 22225                 22230             


Thr Val   Ser Lys Ala Leu Val   Pro Gly Asn Ile Phe   Lys Ser Ser 
    22235                 22240                 22245             


Gly Leu   Thr Asp Gly Ile Ala   Tyr Glu Phe Arg Val   Ile Ala Glu 
    22250                 22255                 22260             


Asn Met   Ala Gly Lys Ser Lys   Pro Ser Lys Pro Ser   Glu Pro Met 
    22265                 22270                 22275             


Leu Ala   Leu Asp Pro Ile Asp   Pro Pro Gly Lys Pro   Val Pro Leu 
    22280                 22285                 22290             


Asn Ile   Thr Arg His Thr Val   Thr Leu Lys Trp Ala   Lys Pro Glu 
    22295                 22300                 22305             


Tyr Thr   Gly Gly Phe Lys Ile   Thr Ser Tyr Ile Val   Glu Lys Arg 
    22310                 22315                 22320             


Asp Leu   Pro Asn Gly Arg Trp   Leu Lys Ala Asn Phe   Ser Asn Ile 
    22325                 22330                 22335             


Leu Glu   Asn Glu Phe Thr Val   Ser Gly Leu Thr Glu   Asp Ala Ala 
    22340                 22345                 22350             


Tyr Glu   Phe Arg Val Ile Ala   Lys Asn Ala Ala Gly   Ala Ile Ser 
    22355                 22360                 22365             


Pro Pro   Ser Glu Pro Ser Asp   Ala Ile Thr Cys Arg   Asp Asp Val 
    22370                 22375                 22380             


Glu Ala   Pro Lys Ile Lys Val   Asp Val Lys Phe Lys   Asp Thr Val 
    22385                 22390                 22395             


Ile Leu   Lys Ala Gly Glu Ala   Phe Arg Leu Glu Ala   Asp Val Ser 
    22400                 22405                 22410             


Gly Arg   Pro Pro Pro Thr Met   Glu Trp Ser Lys Asp   Gly Lys Glu 
    22415                 22420                 22425             


Leu Glu   Gly Thr Ala Lys Leu   Glu Ile Lys Ile Ala   Asp Phe Ser 
    22430                 22435                 22440             


Thr Asn   Leu Val Asn Lys Asp   Ser Thr Arg Arg Asp   Ser Gly Ala 
    22445                 22450                 22455             


Tyr Thr   Leu Thr Ala Thr Asn   Pro Gly Gly Phe Ala   Lys His Ile 
    22460                 22465                 22470             


Phe Asn   Val Lys Val Leu Asp   Arg Pro Gly Pro Pro   Glu Gly Pro 
    22475                 22480                 22485             


Leu Ala   Val Thr Glu Val Thr   Ser Glu Lys Cys Val   Leu Ser Trp 
    22490                 22495                 22500             


Phe Pro   Pro Leu Asp Asp Gly   Gly Ala Lys Ile Asp   His Tyr Ile 
    22505                 22510                 22515             


Val Gln   Lys Arg Glu Thr Ser   Arg Leu Ala Trp Thr   Asn Val Ala 
    22520                 22525                 22530             


Ser Glu   Val Gln Val Thr Lys   Leu Lys Val Thr Lys   Leu Leu Lys 
    22535                 22540                 22545             


Gly Asn   Glu Tyr Ile Phe Arg   Val Met Ala Val Asn   Lys Tyr Gly 
    22550                 22555                 22560             


Val Gly   Glu Pro Leu Glu Ser   Glu Pro Val Leu Ala   Val Asn Pro 
    22565                 22570                 22575             


Tyr Gly   Pro Pro Asp Pro Pro   Lys Asn Pro Glu Val   Thr Thr Ile 
    22580                 22585                 22590             


Thr Lys   Asp Ser Met Val Val   Cys Trp Gly His Pro   Asp Ser Asp 
    22595                 22600                 22605             


Gly Gly   Ser Glu Ile Ile Asn   Tyr Ile Val Glu Arg   Arg Asp Lys 
    22610                 22615                 22620             


Ala Gly   Gln Arg Trp Ile Lys   Cys Asn Lys Lys Thr   Leu Thr Asp 
    22625                 22630                 22635             


Leu Arg   Tyr Lys Val Ser Gly   Leu Thr Glu Gly His   Glu Tyr Glu 
    22640                 22645                 22650             


Phe Arg   Ile Met Ala Glu Asn   Ala Ala Gly Ile Ser   Ala Pro Ser 
    22655                 22660                 22665             


Pro Thr   Ser Pro Phe Tyr Lys   Ala Cys Asp Thr Val   Phe Lys Pro 
    22670                 22675                 22680             


Gly Pro   Pro Gly Asn Pro Arg   Val Leu Asp Thr Ser   Arg Ser Ser 
    22685                 22690                 22695             


Ile Ser   Ile Ala Trp Asn Lys   Pro Ile Tyr Asp Gly   Gly Ser Glu 
    22700                 22705                 22710             


Ile Thr   Gly Tyr Met Val Glu   Ile Ala Leu Pro Glu   Glu Asp Glu 
    22715                 22720                 22725             


Trp Gln   Ile Val Thr Pro Pro   Ala Gly Leu Lys Ala   Thr Ser Tyr 
    22730                 22735                 22740             


Thr Ile   Thr Gly Leu Thr Glu   Asn Gln Glu Tyr Lys   Ile Arg Ile 
    22745                 22750                 22755             


Tyr Ala   Met Asn Ser Glu Gly   Leu Gly Glu Pro Ala   Leu Val Pro 
    22760                 22765                 22770             


Gly Thr   Pro Lys Ala Glu Asp   Arg Met Leu Pro Pro   Glu Ile Glu 
    22775                 22780                 22785             


Leu Asp   Ala Asp Leu Arg Lys   Val Val Thr Ile Arg   Ala Cys Cys 
    22790                 22795                 22800             


Thr Leu   Arg Leu Phe Val Pro   Ile Lys Gly Arg Pro   Ala Pro Glu 
    22805                 22810                 22815             


Val Lys   Trp Ala Arg Asp His   Gly Glu Ser Leu Asp   Lys Ala Ser 
    22820                 22825                 22830             


Ile Glu   Ser Thr Ser Ser Tyr   Thr Leu Leu Ile Val   Gly Asn Val 
    22835                 22840                 22845             


Asn Arg   Phe Asp Ser Gly Lys   Tyr Ile Leu Thr Val   Glu Asn Ser 
    22850                 22855                 22860             


Ser Gly   Ser Lys Ser Ala Phe   Val Asn Val Arg Val   Leu Asp Thr 
    22865                 22870                 22875             


Pro Gly   Pro Pro Gln Asp Leu   Lys Val Lys Glu Val   Thr Lys Thr 
    22880                 22885                 22890             


Ser Val   Thr Leu Thr Trp Asp   Pro Pro Leu Leu Asp   Gly Gly Ser 
    22895                 22900                 22905             


Lys Ile   Lys Asn Tyr Ile Val   Glu Lys Arg Glu Ser   Thr Arg Lys 
    22910                 22915                 22920             


Ala Tyr   Ser Thr Val Ala Thr   Asn Cys His Lys Thr   Ser Trp Lys 
    22925                 22930                 22935             


Val Asp   Gln Leu Gln Glu Gly   Cys Ser Tyr Tyr Phe   Arg Val Leu 
    22940                 22945                 22950             


Ala Glu   Asn Glu Tyr Gly Ile   Gly Leu Pro Ala Glu   Thr Ala Glu 
    22955                 22960                 22965             


Ser Val   Lys Ala Ser Glu Arg   Pro Leu Pro Pro Gly   Lys Ile Thr 
    22970                 22975                 22980             


Leu Met   Asp Val Thr Arg Asn   Ser Val Ser Leu Ser   Trp Glu Lys 
    22985                 22990                 22995             


Pro Glu   His Asp Gly Gly Ser   Arg Ile Leu Gly Tyr   Ile Val Glu 
    23000                 23005                 23010             


Met Gln   Thr Lys Gly Ser Asp   Lys Trp Ala Thr Cys   Ala Thr Val 
    23015                 23020                 23025             


Lys Val   Thr Glu Ala Thr Ile   Thr Gly Leu Ile Gln   Gly Glu Glu 
    23030                 23035                 23040             


Tyr Ser   Phe Arg Val Ser Ala   Gln Asn Glu Lys Gly   Ile Ser Asp 
    23045                 23050                 23055             


Pro Arg   Gln Leu Ser Val Pro   Val Ile Ala Lys Asp   Leu Val Ile 
    23060                 23065                 23070             


Pro Pro   Ala Phe Lys Leu Leu   Phe Asn Thr Phe Thr   Val Leu Ala 
    23075                 23080                 23085             


Gly Glu   Asp Leu Lys Val Asp   Val Pro Phe Ile Gly   Arg Pro Thr 
    23090                 23095                 23100             


Pro Ala   Val Thr Trp His Lys   Asp Asn Val Pro Leu   Lys Gln Thr 
    23105                 23110                 23115             


Thr Arg   Val Asn Ala Glu Ser   Thr Glu Asn Asn Ser   Leu Leu Thr 
    23120                 23125                 23130             


Ile Lys   Asp Ala Cys Arg Glu   Asp Val Gly His Tyr   Val Val Lys 
    23135                 23140                 23145             


Leu Thr   Asn Ser Ala Gly Glu   Ala Ile Glu Thr Leu   Asn Val Ile 
    23150                 23155                 23160             


Val Leu   Asp Lys Pro Gly Pro   Pro Thr Gly Pro Val   Lys Met Asp 
    23165                 23170                 23175             


Glu Val   Thr Ala Asp Ser Ile   Thr Leu Ser Trp Gly   Pro Pro Lys 
    23180                 23185                 23190             


Tyr Asp   Gly Gly Ser Ser Ile   Asn Asn Tyr Ile Val   Glu Lys Arg 
    23195                 23200                 23205             


Asp Thr   Ser Thr Thr Thr Trp   Gln Ile Val Ser Ala   Thr Val Ala 
    23210                 23215                 23220             


Arg Thr   Thr Ile Lys Ala Cys   Arg Leu Lys Thr Gly   Cys Glu Tyr 
    23225                 23230                 23235             


Gln Phe   Arg Ile Ala Ala Glu   Asn Arg Tyr Gly Lys   Ser Thr Tyr 
    23240                 23245                 23250             


Leu Asn   Ser Glu Pro Thr Val   Ala Gln Tyr Pro Phe   Lys Val Pro 
    23255                 23260                 23265             


Gly Pro   Pro Gly Thr Pro Val   Val Thr Leu Ser Ser   Arg Asp Ser 
    23270                 23275                 23280             


Met Glu   Val Gln Trp Asn Glu   Pro Ile Ser Asp Gly   Gly Ser Arg 
    23285                 23290                 23295             


Val Ile   Gly Tyr His Leu Glu   Arg Lys Glu Arg Asn   Ser Ile Leu 
    23300                 23305                 23310             


Trp Val   Lys Leu Asn Lys Thr   Pro Ile Pro Gln Thr   Lys Phe Lys 
    23315                 23320                 23325             


Thr Thr   Gly Leu Glu Glu Gly   Val Glu Tyr Glu Phe   Arg Val Ser 
    23330                 23335                 23340             


Ala Glu   Asn Ile Val Gly Ile   Gly Lys Pro Ser Lys   Val Ser Glu 
    23345                 23350                 23355             


Cys Tyr   Val Ala Arg Asp Pro   Cys Asp Pro Pro Gly   Arg Pro Glu 
    23360                 23365                 23370             


Ala Ile   Ile Val Thr Arg Asn   Ser Val Thr Leu Gln   Trp Lys Lys 
    23375                 23380                 23385             


Pro Thr   Tyr Asp Gly Gly Ser   Lys Ile Thr Gly Tyr   Ile Val Glu 
    23390                 23395                 23400             


Lys Lys   Glu Leu Pro Glu Gly   Arg Trp Met Lys Ala   Ser Phe Thr 
    23405                 23410                 23415             


Asn Ile   Ile Asp Thr His Phe   Glu Val Thr Gly Leu   Val Glu Asp 
    23420                 23425                 23430             


His Arg   Tyr Glu Phe Arg Val   Ile Ala Arg Asn Ala   Ala Gly Val 
    23435                 23440                 23445             


Phe Ser   Glu Pro Ser Glu Ser   Thr Gly Ala Ile Thr   Ala Arg Asp 
    23450                 23455                 23460             


Glu Val   Asp Pro Pro Arg Ile   Ser Met Asp Pro Lys   Tyr Lys Asp 
    23465                 23470                 23475             


Thr Ile   Val Val His Ala Gly   Glu Ser Phe Lys Val   Asp Ala Asp 
    23480                 23485                 23490             


Ile Tyr   Gly Lys Pro Ile Pro   Thr Ile Gln Trp Ile   Lys Gly Asp 
    23495                 23500                 23505             


Gln Glu   Leu Ser Asn Thr Ala   Arg Leu Glu Ile Lys   Ser Thr Asp 
    23510                 23515                 23520             


Phe Ala   Thr Ser Leu Ser Val   Lys Asp Ala Val Arg   Val Asp Ser 
    23525                 23530                 23535             


Gly Asn   Tyr Ile Leu Lys Ala   Lys Asn Val Ala Gly   Glu Arg Ser 
    23540                 23545                 23550             


Val Thr   Val Asn Val Lys Val   Leu Asp Arg Pro Gly   Pro Pro Glu 
    23555                 23560                 23565             


Gly Pro   Val Val Ile Ser Gly   Val Thr Ala Glu Lys   Cys Thr Leu 
    23570                 23575                 23580             


Ala Trp   Lys Pro Pro Leu Gln   Asp Gly Gly Ser Asp   Ile Ile Asn 
    23585                 23590                 23595             


Tyr Ile   Val Glu Arg Arg Glu   Thr Ser Arg Leu Val   Trp Thr Val 
    23600                 23605                 23610             


Val Asp   Ala Asn Val Gln Thr   Leu Ser Cys Lys Val   Thr Lys Leu 
    23615                 23620                 23625             


Leu Glu   Gly Asn Glu Tyr Thr   Phe Arg Ile Met Ala   Val Asn Lys 
    23630                 23635                 23640             


Tyr Gly   Val Gly Glu Pro Leu   Glu Ser Glu Pro Val   Val Ala Lys 
    23645                 23650                 23655             


Asn Pro   Phe Val Val Pro Asp   Ala Pro Lys Ala Pro   Glu Val Thr 
    23660                 23665                 23670             


Thr Val   Thr Lys Asp Ser Met   Ile Val Val Trp Glu   Arg Pro Ala 
    23675                 23680                 23685             


Ser Asp   Gly Gly Ser Glu Ile   Leu Gly Tyr Val Leu   Glu Lys Arg 
    23690                 23695                 23700             


Asp Lys   Glu Gly Ile Arg Trp   Thr Arg Cys His Lys   Arg Leu Ile 
    23705                 23710                 23715             


Gly Glu   Leu Arg Leu Arg Val   Thr Gly Leu Ile Glu   Asn His Asp 
    23720                 23725                 23730             


Tyr Glu   Phe Arg Val Ser Ala   Glu Asn Ala Ala Gly   Leu Ser Glu 
    23735                 23740                 23745             


Pro Ser   Pro Pro Ser Ala Tyr   Gln Lys Ala Cys Asp   Pro Ile Tyr 
    23750                 23755                 23760             


Lys Pro   Gly Pro Pro Asn Asn   Pro Lys Val Ile Asp   Ile Thr Arg 
    23765                 23770                 23775             


Ser Ser   Val Phe Leu Ser Trp   Ser Lys Pro Ile Tyr   Asp Gly Gly 
    23780                 23785                 23790             


Cys Glu   Ile Gln Gly Tyr Ile   Val Glu Lys Cys Asp   Val Ser Val 
    23795                 23800                 23805             


Gly Glu   Trp Thr Met Cys Thr   Pro Pro Thr Gly Ile   Asn Lys Thr 
    23810                 23815                 23820             


Asn Ile   Glu Val Glu Lys Leu   Leu Glu Lys His Glu   Tyr Asn Phe 
    23825                 23830                 23835             


Arg Ile   Cys Ala Ile Asn Lys   Ala Gly Val Gly Glu   His Ala Asp 
    23840                 23845                 23850             


Val Pro   Gly Pro Ile Ile Val   Glu Glu Lys Leu Glu   Ala Pro Asp 
    23855                 23860                 23865             


Ile Asp   Leu Asp Leu Glu Leu   Arg Lys Ile Ile Asn   Ile Arg Ala 
    23870                 23875                 23880             


Gly Gly   Ser Leu Arg Leu Phe   Val Pro Ile Lys Gly   Arg Pro Thr 
    23885                 23890                 23895             


Pro Glu   Val Lys Trp Gly Lys   Val Asp Gly Glu Ile   Arg Asp Ala 
    23900                 23905                 23910             


Ala Ile   Ile Asp Val Thr Ser   Ser Phe Thr Ser Leu   Val Leu Asp 
    23915                 23920                 23925             


Asn Val   Asn Arg Tyr Asp Ser   Gly Lys Tyr Thr Leu   Thr Leu Glu 
    23930                 23935                 23940             


Asn Ser   Ser Gly Thr Lys Ser   Ala Phe Val Thr Val   Arg Val Leu 
    23945                 23950                 23955             


Asp Thr   Pro Ser Pro Pro Val   Asn Leu Lys Val Thr   Glu Ile Thr 
    23960                 23965                 23970             


Lys Asp   Ser Val Ser Ile Thr   Trp Glu Pro Pro Leu   Leu Asp Gly 
    23975                 23980                 23985             


Gly Ser   Lys Ile Lys Asn Tyr   Ile Val Glu Lys Arg   Glu Ala Thr 
    23990                 23995                 24000             


Arg Lys   Ser Tyr Ala Ala Val   Val Thr Asn Cys His   Lys Asn Ser 
    24005                 24010                 24015             


Trp Lys   Ile Asp Gln Leu Gln   Glu Gly Cys Ser Tyr   Tyr Phe Arg 
    24020                 24025                 24030             


Val Thr   Ala Glu Asn Glu Tyr   Gly Ile Gly Leu Pro   Ala Gln Thr 
    24035                 24040                 24045             


Ala Asp   Pro Ile Lys Val Ala   Glu Val Pro Gln Pro   Pro Gly Lys 
    24050                 24055                 24060             


Ile Thr   Val Asp Asp Val Thr   Arg Asn Ser Val Ser   Leu Ser Trp 
    24065                 24070                 24075             


Thr Lys   Pro Glu His Asp Gly   Gly Ser Lys Ile Ile   Gln Tyr Ile 
    24080                 24085                 24090             


Val Glu   Met Gln Ala Lys His   Ser Glu Lys Trp Ser   Glu Cys Ala 
    24095                 24100                 24105             


Arg Val   Lys Ser Leu Gln Ala   Val Ile Thr Asn Leu   Thr Gln Gly 
    24110                 24115                 24120             


Glu Glu   Tyr Leu Phe Arg Val   Val Ala Val Asn Glu   Lys Gly Arg 
    24125                 24130                 24135             


Ser Asp   Pro Arg Ser Leu Ala   Val Pro Ile Val Ala   Lys Asp Leu 
    24140                 24145                 24150             


Val Ile   Glu Pro Asp Val Lys   Pro Ala Phe Ser Ser   Tyr Ser Val 
    24155                 24160                 24165             


Gln Val   Gly Gln Asp Leu Lys   Ile Glu Val Pro Ile   Ser Gly Arg 
    24170                 24175                 24180             


Pro Lys   Pro Thr Ile Thr Trp   Thr Lys Asp Gly Leu   Pro Leu Lys 
    24185                 24190                 24195             


Gln Thr   Thr Arg Ile Asn Val   Thr Asp Ser Leu Asp   Leu Thr Thr 
    24200                 24205                 24210             


Leu Ser   Ile Lys Glu Thr His   Lys Asp Asp Gly Gly   Gln Tyr Gly 
    24215                 24220                 24225             


Ile Thr   Val Ala Asn Val Val   Gly Gln Lys Thr Ala   Ser Ile Glu 
    24230                 24235                 24240             


Ile Val   Thr Leu Asp Lys Pro   Asp Pro Pro Lys Gly   Pro Val Lys 
    24245                 24250                 24255             


Phe Asp   Asp Val Ser Ala Glu   Ser Ile Thr Leu Ser   Trp Asn Pro 
    24260                 24265                 24270             


Pro Leu   Tyr Thr Gly Gly Cys   Gln Ile Thr Asn Tyr   Ile Val Gln 
    24275                 24280                 24285             


Lys Arg   Asp Thr Thr Thr Thr   Val Trp Asp Val Val   Ser Ala Thr 
    24290                 24295                 24300             


Val Ala   Arg Thr Thr Leu Lys   Val Thr Lys Leu Lys   Thr Gly Thr 
    24305                 24310                 24315             


Glu Tyr   Gln Phe Arg Ile Phe   Ala Glu Asn Arg Tyr   Gly Gln Ser 
    24320                 24325                 24330             


Phe Ala   Leu Glu Ser Asp Pro   Ile Val Ala Gln Tyr   Pro Tyr Lys 
    24335                 24340                 24345             


Glu Pro   Gly Pro Pro Gly Thr   Pro Phe Ala Thr Ala   Ile Ser Lys 
    24350                 24355                 24360             


Asp Ser   Met Val Ile Gln Trp   His Glu Pro Val Asn   Asn Gly Gly 
    24365                 24370                 24375             


Ser Pro   Val Ile Gly Tyr His   Leu Glu Arg Lys Glu   Arg Asn Ser 
    24380                 24385                 24390             


Ile Leu   Trp Thr Lys Val Asn   Lys Thr Ile Ile His   Asp Thr Gln 
    24395                 24400                 24405             


Phe Lys   Ala Gln Asn Leu Glu   Glu Gly Ile Glu Tyr   Glu Phe Arg 
    24410                 24415                 24420             


Val Tyr   Ala Glu Asn Ile Val   Gly Val Gly Lys Ala   Ser Lys Asn 
    24425                 24430                 24435             


Ser Glu   Cys Tyr Val Ala Arg   Asp Pro Cys Asp Pro   Pro Gly Thr 
    24440                 24445                 24450             


Pro Glu   Pro Ile Met Val Lys   Arg Asn Glu Ile Thr   Leu Gln Trp 
    24455                 24460                 24465             


Thr Lys   Pro Val Tyr Asp Gly   Gly Ser Met Ile Thr   Gly Tyr Ile 
    24470                 24475                 24480             


Val Glu   Lys Arg Asp Leu Pro   Asp Gly Arg Trp Met   Lys Ala Ser 
    24485                 24490                 24495             


Phe Thr   Asn Val Ile Glu Thr   Gln Phe Thr Val Ser   Gly Leu Thr 
    24500                 24505                 24510             


Glu Asp   Gln Arg Tyr Glu Phe   Arg Val Ile Ala Lys   Asn Ala Ala 
    24515                 24520                 24525             


Gly Ala   Ile Ser Lys Pro Ser   Asp Ser Thr Gly Pro   Ile Thr Ala 
    24530                 24535                 24540             


Lys Asp   Glu Val Glu Leu Pro   Arg Ile Ser Met Asp   Pro Lys Phe 
    24545                 24550                 24555             


Arg Asp   Thr Ile Val Val Asn   Ala Gly Glu Thr Phe   Arg Leu Glu 
    24560                 24565                 24570             


Ala Asp   Val His Gly Lys Pro   Leu Pro Thr Ile Glu   Trp Leu Arg 
    24575                 24580                 24585             


Gly Asp   Lys Glu Ile Glu Glu   Ser Ala Arg Cys Glu   Ile Lys Asn 
    24590                 24595                 24600             


Thr Asp   Phe Lys Ala Leu Leu   Ile Val Lys Asp Ala   Ile Arg Ile 
    24605                 24610                 24615             


Asp Gly   Gly Gln Tyr Ile Leu   Arg Ala Ser Asn Val   Ala Gly Ser 
    24620                 24625                 24630             


Lys Ser   Phe Pro Val Asn Val   Lys Val Leu Asp Arg   Pro Gly Pro 
    24635                 24640                 24645             


Pro Glu   Gly Pro Val Gln Val   Thr Gly Val Thr Ser   Glu Lys Cys 
    24650                 24655                 24660             


Ser Leu   Thr Trp Ser Pro Pro   Leu Gln Asp Gly Gly   Ser Asp Ile 
    24665                 24670                 24675             


Ser His   Tyr Val Val Glu Lys   Arg Glu Thr Ser Arg   Leu Ala Trp 
    24680                 24685                 24690             


Thr Val   Val Ala Ser Glu Val   Val Thr Asn Ser Leu   Lys Val Thr 
    24695                 24700                 24705             


Lys Leu   Leu Glu Gly Asn Glu   Tyr Val Phe Arg Ile   Met Ala Val 
    24710                 24715                 24720             


Asn Lys   Tyr Gly Val Gly Glu   Pro Leu Glu Ser Ala   Pro Val Leu 
    24725                 24730                 24735             


Met Lys   Asn Pro Phe Val Leu   Pro Gly Pro Pro Lys   Ser Leu Glu 
    24740                 24745                 24750             


Val Thr   Asn Ile Ala Lys Asp   Ser Met Thr Val Cys   Trp Asn Arg 
    24755                 24760                 24765             


Pro Asp   Ser Asp Gly Gly Ser   Glu Ile Ile Gly Tyr   Ile Val Glu 
    24770                 24775                 24780             


Lys Arg   Asp Arg Ser Gly Ile   Arg Trp Ile Lys Cys   Asn Lys Arg 
    24785                 24790                 24795             


Arg Ile   Thr Asp Leu Arg Leu   Arg Val Thr Gly Leu   Thr Glu Asp 
    24800                 24805                 24810             


His Glu   Tyr Glu Phe Arg Val   Ser Ala Glu Asn Ala   Ala Gly Val 
    24815                 24820                 24825             


Gly Glu   Pro Ser Pro Ala Thr   Val Tyr Tyr Lys Ala   Cys Asp Pro 
    24830                 24835                 24840             


Val Phe   Lys Pro Gly Pro Pro   Thr Asn Ala His Ile   Val Asp Thr 
    24845                 24850                 24855             


Thr Lys   Asn Ser Ile Thr Leu   Ala Trp Gly Lys Pro   Ile Tyr Asp 
    24860                 24865                 24870             


Gly Gly   Ser Glu Ile Leu Gly   Tyr Val Val Glu Ile   Cys Lys Ala 
    24875                 24880                 24885             


Asp Glu   Glu Glu Trp Gln Ile   Val Thr Pro Gln Thr   Gly Leu Arg 
    24890                 24895                 24900             


Val Thr   Arg Phe Glu Ile Ser   Lys Leu Thr Glu His   Gln Glu Tyr 
    24905                 24910                 24915             


Lys Ile   Arg Val Cys Ala Leu   Asn Lys Val Gly Leu   Gly Glu Ala 
    24920                 24925                 24930             


Thr Ser   Val Pro Gly Thr Val   Lys Pro Glu Asp Lys   Leu Glu Ala 
    24935                 24940                 24945             


Pro Glu   Leu Asp Leu Asp Ser   Glu Leu Arg Lys Gly   Ile Val Val 
    24950                 24955                 24960             


Arg Ala   Gly Gly Ser Ala Arg   Ile His Ile Pro Phe   Lys Gly Arg 
    24965                 24970                 24975             


Pro Thr   Pro Glu Ile Thr Trp   Ser Arg Glu Glu Gly   Glu Phe Thr 
    24980                 24985                 24990             


Asp Lys   Val Gln Ile Glu Lys   Gly Val Asn Tyr Thr   Gln Leu Ser 
    24995                 25000                 25005             


Ile Asp   Asn Cys Asp Arg Asn   Asp Ala Gly Lys Tyr   Ile Leu Lys 
    25010                 25015                 25020             


Leu Glu   Asn Ser Ser Gly Ser   Lys Ser Ala Phe Val   Thr Val Lys 
    25025                 25030                 25035             


Val Leu   Asp Thr Pro Gly Pro   Pro Gln Asn Leu Ala   Val Lys Glu 
    25040                 25045                 25050             


Val Arg   Lys Asp Ser Ala Phe   Leu Val Trp Glu Pro   Pro Ile Ile 
    25055                 25060                 25065             


Asp Gly   Gly Ala Lys Val Lys   Asn Tyr Val Ile Asp   Lys Arg Glu 
    25070                 25075                 25080             


Ser Thr   Arg Lys Ala Tyr Ala   Asn Val Ser Ser Lys   Cys Ser Lys 
    25085                 25090                 25095             


Thr Ser   Phe Lys Val Glu Asn   Leu Thr Glu Gly Ala   Ile Tyr Tyr 
    25100                 25105                 25110             


Phe Arg   Val Met Ala Glu Asn   Glu Phe Gly Val Gly   Val Pro Val 
    25115                 25120                 25125             


Glu Thr   Val Asp Ala Val Lys   Ala Ala Glu Pro Pro   Ser Pro Pro 
    25130                 25135                 25140             


Gly Lys   Val Thr Leu Thr Asp   Val Ser Gln Thr Ser   Ala Ser Leu 
    25145                 25150                 25155             


Met Trp   Glu Lys Pro Glu His   Asp Gly Gly Ser Arg   Val Leu Gly 
    25160                 25165                 25170             


Tyr Val   Val Glu Met Gln Pro   Lys Gly Thr Glu Lys   Trp Ser Ile 
    25175                 25180                 25185             


Val Ala   Glu Ser Lys Val Cys   Asn Ala Val Val Thr   Gly Leu Ser 
    25190                 25195                 25200             


Ser Gly   Gln Glu Tyr Gln Phe   Arg Val Lys Ala Tyr   Asn Glu Lys 
    25205                 25210                 25215             


Gly Lys   Ser Asp Pro Arg Val   Leu Gly Val Pro Val   Ile Ala Lys 
    25220                 25225                 25230             


Asp Leu   Thr Ile Gln Pro Ser   Leu Lys Leu Pro Phe   Asn Thr Tyr 
    25235                 25240                 25245             


Ser Ile   Gln Ala Gly Glu Asp   Leu Lys Ile Glu Ile   Pro Val Ile 
    25250                 25255                 25260             


Gly Arg   Pro Arg Pro Asn Ile   Ser Trp Val Lys Asp   Gly Glu Pro 
    25265                 25270                 25275             


Leu Lys   Gln Thr Thr Arg Val   Asn Val Glu Glu Thr   Ala Thr Ser 
    25280                 25285                 25290             


Thr Val   Leu His Ile Lys Glu   Gly Asn Lys Asp Asp   Phe Gly Lys 
    25295                 25300                 25305             


Tyr Thr   Val Thr Ala Thr Asn   Ser Ala Gly Thr Ala   Thr Glu Asn 
    25310                 25315                 25320             


Leu Ser   Val Ile Val Leu Glu   Lys Pro Gly Pro Pro   Val Gly Pro 
    25325                 25330                 25335             


Val Arg   Phe Asp Glu Val Ser   Ala Asp Phe Val Val   Ile Ser Trp 
    25340                 25345                 25350             


Glu Pro   Pro Ala Tyr Thr Gly   Gly Cys Gln Ile Ser   Asn Tyr Ile 
    25355                 25360                 25365             


Val Glu   Lys Arg Asp Thr Thr   Thr Thr Thr Trp His   Met Val Ser 
    25370                 25375                 25380             


Ala Thr   Val Ala Arg Thr Thr   Ile Lys Ile Thr Lys   Leu Lys Thr 
    25385                 25390                 25395             


Gly Thr   Glu Tyr Gln Phe Arg   Ile Phe Ala Glu Asn   Arg Tyr Gly 
    25400                 25405                 25410             


Lys Ser   Ala Pro Leu Asp Ser   Lys Ala Val Ile Val   Gln Tyr Pro 
    25415                 25420                 25425             


Phe Lys   Glu Pro Gly Pro Pro   Gly Thr Pro Phe Val   Thr Ser Ile 
    25430                 25435                 25440             


Ser Lys   Asp Gln Met Leu Val   Gln Trp His Glu Pro   Val Asn Asp 
    25445                 25450                 25455             


Gly Gly   Thr Lys Ile Ile Gly   Tyr His Leu Glu Gln   Lys Glu Lys 
    25460                 25465                 25470             


Asn Ser   Ile Leu Trp Val Lys   Leu Asn Lys Thr Pro   Ile Gln Asp 
    25475                 25480                 25485             


Thr Lys   Phe Lys Thr Thr Gly   Leu Asp Glu Gly Leu   Glu Tyr Glu 
    25490                 25495                 25500             


Phe Lys   Val Ser Ala Glu Asn   Ile Val Gly Ile Gly   Lys Pro Ser 
    25505                 25510                 25515             


Lys Val   Ser Glu Cys Phe Val   Ala Arg Asp Pro Cys   Asp Pro Pro 
    25520                 25525                 25530             


Gly Arg   Pro Glu Ala Ile Val   Ile Thr Arg Asn Asn   Val Thr Leu 
    25535                 25540                 25545             


Lys Trp   Lys Lys Pro Ala Tyr   Asp Gly Gly Ser Lys   Ile Thr Gly 
    25550                 25555                 25560             


Tyr Ile   Val Glu Lys Lys Asp   Leu Pro Asp Gly Arg   Trp Met Lys 
    25565                 25570                 25575             


Ala Ser   Phe Thr Asn Val Leu   Glu Thr Glu Phe Thr   Val Ser Gly 
    25580                 25585                 25590             


Leu Val   Glu Asp Gln Arg Tyr   Glu Phe Arg Val Ile   Ala Arg Asn 
    25595                 25600                 25605             


Ala Ala   Gly Asn Phe Ser Glu   Pro Ser Asp Ser Ser   Gly Ala Ile 
    25610                 25615                 25620             


Thr Ala   Arg Asp Glu Ile Asp   Ala Pro Asn Ala Ser   Leu Asp Pro 
    25625                 25630                 25635             


Lys Tyr   Lys Asp Val Ile Val   Val His Ala Gly Glu   Thr Phe Val 
    25640                 25645                 25650             


Leu Glu   Ala Asp Ile Arg Gly   Lys Pro Ile Pro Asp   Val Val Trp 
    25655                 25660                 25665             


Ser Lys   Asp Gly Lys Glu Leu   Glu Glu Thr Ala Ala   Arg Met Glu 
    25670                 25675                 25680             


Ile Lys   Ser Thr Ile Gln Lys   Thr Thr Leu Val Val   Lys Asp Cys 
    25685                 25690                 25695             


Ile Arg   Thr Asp Gly Gly Gln   Tyr Ile Leu Lys Leu   Ser Asn Val 
    25700                 25705                 25710             


Gly Gly   Thr Lys Ser Ile Pro   Ile Thr Val Lys Val   Leu Asp Arg 
    25715                 25720                 25725             


Pro Gly   Pro Pro Glu Gly Pro   Leu Lys Val Thr Gly   Val Thr Ala 
    25730                 25735                 25740             


Glu Lys   Cys Tyr Leu Ala Trp   Asn Pro Pro Leu Gln   Asp Gly Gly 
    25745                 25750                 25755             


Ala Asn   Ile Ser His Tyr Ile   Ile Glu Lys Arg Glu   Thr Ser Arg 
    25760                 25765                 25770             


Leu Ser   Trp Thr Gln Val Ser   Thr Glu Val Gln Ala   Leu Asn Tyr 
    25775                 25780                 25785             


Lys Val   Thr Lys Leu Leu Pro   Gly Asn Glu Tyr Ile   Phe Arg Val 
    25790                 25795                 25800             


Met Ala   Val Asn Lys Tyr Gly   Ile Gly Glu Pro Leu   Glu Ser Gly 
    25805                 25810                 25815             


Pro Val   Thr Ala Cys Asn Pro   Tyr Lys Pro Pro Gly   Pro Pro Ser 
    25820                 25825                 25830             


Thr Pro   Glu Val Ser Ala Ile   Thr Lys Asp Ser Met   Val Val Thr 
    25835                 25840                 25845             


Trp Ala   Arg Pro Val Asp Asp   Gly Gly Thr Glu Ile   Glu Gly Tyr 
    25850                 25855                 25860             


Ile Leu   Glu Lys Arg Asp Lys   Glu Gly Val Arg Trp   Thr Lys Cys 
    25865                 25870                 25875             


Asn Lys   Lys Thr Leu Thr Asp   Leu Arg Leu Arg Val   Thr Gly Leu 
    25880                 25885                 25890             


Thr Glu   Gly His Ser Tyr Glu   Phe Arg Val Ala Ala   Glu Asn Ala 
    25895                 25900                 25905             


Ala Gly   Val Gly Glu Pro Ser   Glu Pro Ser Val Phe   Tyr Arg Ala 
    25910                 25915                 25920             


Cys Asp   Ala Leu Tyr Pro Pro   Gly Pro Pro Ser Asn   Pro Lys Val 
    25925                 25930                 25935             


Thr Asp   Thr Ser Arg Ser Ser   Val Ser Leu Ala Trp   Ser Lys Pro 
    25940                 25945                 25950             


Ile Tyr   Asp Gly Gly Ala Pro   Val Lys Gly Tyr Val   Val Glu Val 
    25955                 25960                 25965             


Lys Glu   Ala Ala Ala Asp Glu   Trp Thr Thr Cys Thr   Pro Pro Thr 
    25970                 25975                 25980             


Gly Leu   Gln Gly Lys Gln Phe   Thr Val Thr Lys Leu   Lys Glu Asn 
    25985                 25990                 25995             


Thr Glu   Tyr Asn Phe Arg Ile   Cys Ala Ile Asn Ser   Glu Gly Val 
    26000                 26005                 26010             


Gly Glu   Pro Ala Thr Leu Pro   Gly Ser Val Val Ala   Gln Glu Arg 
    26015                 26020                 26025             


Ile Glu   Pro Pro Glu Ile Glu   Leu Asp Ala Asp Leu   Arg Lys Val 
    26030                 26035                 26040             


Val Val   Leu Arg Ala Ser Ala   Thr Leu Arg Leu Phe   Val Thr Ile 
    26045                 26050                 26055             


Lys Gly   Arg Pro Glu Pro Glu   Val Lys Trp Glu Lys   Ala Glu Gly 
    26060                 26065                 26070             


Ile Leu   Thr Asp Arg Ala Gln   Ile Glu Val Thr Ser   Ser Phe Thr 
    26075                 26080                 26085             


Met Leu   Val Ile Asp Asn Val   Thr Arg Phe Asp Ser   Gly Arg Tyr 
    26090                 26095                 26100             


Asn Leu   Thr Leu Glu Asn Asn   Ser Gly Ser Lys Thr   Ala Phe Val 
    26105                 26110                 26115             


Asn Val   Arg Val Leu Asp Ser   Pro Ser Ala Pro Val   Asn Leu Thr 
    26120                 26125                 26130             


Ile Arg   Glu Val Lys Lys Asp   Ser Val Thr Leu Ser   Trp Glu Pro 
    26135                 26140                 26145             


Pro Leu   Ile Asp Gly Gly Ala   Lys Ile Thr Asn Tyr   Ile Val Glu 
    26150                 26155                 26160             


Lys Arg   Glu Thr Thr Arg Lys   Ala Tyr Ala Thr Ile   Thr Asn Asn 
    26165                 26170                 26175             


Cys Thr   Lys Thr Thr Phe Arg   Ile Glu Asn Leu Gln   Glu Gly Cys 
    26180                 26185                 26190             


Ser Tyr   Tyr Phe Arg Val Leu   Ala Ser Asn Glu Tyr   Gly Ile Gly 
    26195                 26200                 26205             


Leu Pro   Ala Glu Thr Thr Glu   Pro Val Lys Val Ser   Glu Pro Pro 
    26210                 26215                 26220             


Leu Pro   Pro Gly Arg Val Thr   Leu Val Asp Val Thr   Arg Asn Thr 
    26225                 26230                 26235             


Ala Thr   Ile Lys Trp Glu Lys   Pro Glu Ser Asp Gly   Gly Ser Lys 
    26240                 26245                 26250             


Ile Thr   Gly Tyr Val Val Glu   Met Gln Thr Lys Gly   Ser Glu Lys 
    26255                 26260                 26265             


Trp Ser   Thr Cys Thr Gln Val   Lys Thr Leu Glu Ala   Thr Ile Ser 
    26270                 26275                 26280             


Gly Leu   Thr Ala Gly Glu Glu   Tyr Val Phe Arg Val   Ala Ala Val 
    26285                 26290                 26295             


Asn Glu   Lys Gly Arg Ser Asp   Pro Arg Gln Leu Gly   Val Pro Val 
    26300                 26305                 26310             


Ile Ala   Arg Asp Ile Glu Ile   Lys Pro Ser Val Glu   Leu Pro Phe 
    26315                 26320                 26325             


His Thr   Phe Asn Val Lys Ala   Arg Glu Gln Leu Lys   Ile Asp Val 
    26330                 26335                 26340             


Pro Phe   Lys Gly Arg Pro Gln   Ala Thr Val Asn Trp   Arg Lys Asp 
    26345                 26350                 26355             


Gly Gln   Thr Leu Lys Glu Thr   Thr Arg Val Asn Val   Ser Ser Ser 
    26360                 26365                 26370             


Lys Thr   Val Thr Ser Leu Ser   Ile Lys Glu Ala Ser   Lys Glu Asp 
    26375                 26380                 26385             


Val Gly   Thr Tyr Glu Leu Cys   Val Ser Asn Ser Ala   Gly Ser Ile 
    26390                 26395                 26400             


Thr Val   Pro Ile Thr Ile Ile   Val Leu Asp Arg Pro   Gly Pro Pro 
    26405                 26410                 26415             


Gly Pro   Ile Arg Ile Asp Glu   Val Ser Cys Asp Ser   Ile Thr Ile 
    26420                 26425                 26430             


Ser Trp   Asn Pro Pro Glu Tyr   Asp Gly Gly Cys Gln   Ile Ser Asn 
    26435                 26440                 26445             


Tyr Ile   Val Glu Lys Lys Glu   Thr Thr Ser Thr Thr   Trp His Ile 
    26450                 26455                 26460             


Val Ser   Gln Ala Val Ala Arg   Thr Ser Ile Lys Ile   Val Arg Leu 
    26465                 26470                 26475             


Thr Thr   Gly Ser Glu Tyr Gln   Phe Arg Val Cys Ala   Glu Asn Arg 
    26480                 26485                 26490             


Tyr Gly   Lys Ser Ser Tyr Ser   Glu Ser Ser Ala Val   Val Ala Glu 
    26495                 26500                 26505             


Tyr Pro   Phe Ser Pro Pro Gly   Pro Pro Gly Thr Pro   Lys Val Val 
    26510                 26515                 26520             


His Ala   Thr Lys Ser Thr Met   Leu Val Thr Trp Gln   Val Pro Val 
    26525                 26530                 26535             


Asn Asp   Gly Gly Ser Arg Val   Ile Gly Tyr His Leu   Glu Tyr Lys 
    26540                 26545                 26550             


Glu Arg   Ser Ser Ile Leu Trp   Ser Lys Ala Asn Lys   Ile Leu Ile 
    26555                 26560                 26565             


Ala Asp   Thr Gln Met Lys Val   Ser Gly Leu Asp Glu   Gly Leu Met 
    26570                 26575                 26580             


Tyr Glu   Tyr Arg Val Tyr Ala   Glu Asn Ile Ala Gly   Ile Gly Lys 
    26585                 26590                 26595             


Cys Ser   Lys Ser Cys Glu Pro   Val Pro Ala Arg Asp   Pro Cys Asp 
    26600                 26605                 26610             


Pro Pro   Gly Gln Pro Glu Val   Thr Asn Ile Thr Arg   Lys Ser Val 
    26615                 26620                 26625             


Ser Leu   Lys Trp Ser Lys Pro   His Tyr Asp Gly Gly   Ala Lys Ile 
    26630                 26635                 26640             


Thr Gly   Tyr Ile Val Glu Arg   Arg Glu Leu Pro Asp   Gly Arg Trp 
    26645                 26650                 26655             


Leu Lys   Cys Asn Tyr Thr Asn   Ile Gln Glu Thr Tyr   Phe Glu Val 
    26660                 26665                 26670             


Thr Glu   Leu Thr Glu Asp Gln   Arg Tyr Glu Phe Arg   Val Phe Ala 
    26675                 26680                 26685             


Arg Asn   Ala Ala Asp Ser Val   Ser Glu Pro Ser Glu   Ser Thr Gly 
    26690                 26695                 26700             


Pro Ile   Ile Val Lys Asp Asp   Val Glu Pro Pro Arg   Val Met Met 
    26705                 26710                 26715             


Asp Val   Lys Phe Arg Asp Val   Ile Val Val Lys Ala   Gly Glu Val 
    26720                 26725                 26730             


Leu Lys   Ile Asn Ala Asp Ile   Ala Gly Arg Pro Leu   Pro Val Ile 
    26735                 26740                 26745             


Ser Trp   Ala Lys Asp Gly Ile   Glu Ile Glu Glu Arg   Ala Arg Thr 
    26750                 26755                 26760             


Glu Ile   Ile Ser Thr Asp Asn   His Thr Leu Leu Thr   Val Lys Asp 
    26765                 26770                 26775             


Cys Ile   Arg Arg Asp Thr Gly   Gln Tyr Val Leu Thr   Leu Lys Asn 
    26780                 26785                 26790             


Val Ala   Gly Thr Arg Ser Val   Ala Val Asn Cys Lys   Val Leu Asp 
    26795                 26800                 26805             


Lys Pro   Gly Pro Pro Ala Gly   Pro Leu Glu Ile Asn   Gly Leu Thr 
    26810                 26815                 26820             


Ala Glu   Lys Cys Ser Leu Ser   Trp Gly Arg Pro Gln   Glu Asp Gly 
    26825                 26830                 26835             


Gly Ala   Asp Ile Asp Tyr Tyr   Ile Val Glu Lys Arg   Glu Thr Ser 
    26840                 26845                 26850             


His Leu   Ala Trp Thr Ile Cys   Glu Gly Glu Leu Gln   Met Thr Ser 
    26855                 26860                 26865             


Cys Lys   Val Thr Lys Leu Leu   Lys Gly Asn Glu Tyr   Ile Phe Arg 
    26870                 26875                 26880             


Val Thr   Gly Val Asn Lys Tyr   Gly Val Gly Glu Pro   Leu Glu Ser 
    26885                 26890                 26895             


Val Ala   Ile Lys Ala Leu Asp   Pro Phe Thr Val Pro   Ser Pro Pro 
    26900                 26905                 26910             


Thr Ser   Leu Glu Ile Thr Ser   Val Thr Lys Glu Ser   Met Thr Leu 
    26915                 26920                 26925             


Cys Trp   Ser Arg Pro Glu Ser   Asp Gly Gly Ser Glu   Ile Ser Gly 
    26930                 26935                 26940             


Tyr Ile   Ile Glu Arg Arg Glu   Lys Asn Ser Leu Arg   Trp Val Arg 
    26945                 26950                 26955             


Val Asn   Lys Lys Pro Val Tyr   Asp Leu Arg Val Lys   Ser Thr Gly 
    26960                 26965                 26970             


Leu Arg   Glu Gly Cys Glu Tyr   Glu Tyr Arg Val Tyr   Ala Glu Asn 
    26975                 26980                 26985             


Ala Ala   Gly Leu Ser Leu Pro   Ser Glu Thr Ser Pro   Leu Ile Arg 
    26990                 26995                 27000             


Ala Glu   Asp Pro Val Phe Leu   Pro Ser Pro Pro Ser   Lys Pro Lys 
    27005                 27010                 27015             


Ile Val   Asp Ser Gly Lys Thr   Thr Ile Thr Ile Ala   Trp Val Lys 
    27020                 27025                 27030             


Pro Leu   Phe Asp Gly Gly Ala   Pro Ile Thr Gly Tyr   Thr Val Glu 
    27035                 27040                 27045             


Tyr Lys   Lys Ser Asp Asp Thr   Asp Trp Lys Thr Ser   Ile Gln Ser 
    27050                 27055                 27060             


Leu Arg   Gly Thr Glu Tyr Thr   Ile Ser Gly Leu Thr   Thr Gly Ala 
    27065                 27070                 27075             


Glu Tyr   Val Phe Arg Val Lys   Ser Val Asn Lys Val   Gly Ala Ser 
    27080                 27085                 27090             


Asp Pro   Ser Asp Ser Ser Asp   Pro Gln Ile Ala Lys   Glu Arg Glu 
    27095                 27100                 27105             


Glu Glu   Pro Leu Phe Asp Ile   Asp Ser Glu Met Arg   Lys Thr Leu 
    27110                 27115                 27120             


Ile Val   Lys Ala Gly Ala Ser   Phe Thr Met Thr Val   Pro Phe Arg 
    27125                 27130                 27135             


Gly Arg   Pro Val Pro Asn Val   Leu Trp Ser Lys Pro   Asp Thr Asp 
    27140                 27145                 27150             


Leu Arg   Thr Arg Ala Tyr Val   Asp Thr Thr Asp Ser   Arg Thr Ser 
    27155                 27160                 27165             


Leu Thr   Ile Glu Asn Ala Asn   Arg Asn Asp Ser Gly   Lys Tyr Thr 
    27170                 27175                 27180             


Leu Thr   Ile Gln Asn Val Leu   Ser Ala Ala Ser Leu   Thr Leu Val 
    27185                 27190                 27195             


Val Lys   Val Leu Asp Thr Pro   Gly Pro Pro Thr Asn   Ile Thr Val 
    27200                 27205                 27210             


Gln Asp   Val Thr Lys Glu Ser   Ala Val Leu Ser Trp   Asp Val Pro 
    27215                 27220                 27225             


Glu Asn   Asp Gly Gly Ala Pro   Val Lys Asn Tyr His   Ile Glu Lys 
    27230                 27235                 27240             


Arg Glu   Ala Ser Lys Lys Ala   Trp Val Ser Val Thr   Asn Asn Cys 
    27245                 27250                 27255             


Asn Arg   Leu Ser Tyr Lys Val   Thr Asn Leu Gln Glu   Gly Ala Ile 
    27260                 27265                 27270             


Tyr Tyr   Phe Arg Val Ser Gly   Glu Asn Glu Phe Gly   Val Gly Ile 
    27275                 27280                 27285             


Pro Ala   Glu Thr Lys Glu Gly   Val Lys Ile Thr Glu   Lys Pro Ser 
    27290                 27295                 27300             


Pro Pro   Glu Lys Leu Gly Val   Thr Ser Ile Ser Lys   Asp Ser Val 
    27305                 27310                 27315             


Ser Leu   Thr Trp Leu Lys Pro   Glu His Asp Gly Gly   Ser Arg Ile 
    27320                 27325                 27330             


Val His   Tyr Val Val Glu Ala   Leu Glu Lys Gly Gln   Lys Asn Trp 
    27335                 27340                 27345             


Val Lys   Cys Ala Val Ala Lys   Ser Thr His His Val   Val Ser Gly 
    27350                 27355                 27360             


Leu Arg   Glu Asn Ser Glu Tyr   Phe Phe Arg Val Phe   Ala Glu Asn 
    27365                 27370                 27375             


Gln Ala   Gly Leu Ser Asp Pro   Arg Glu Leu Leu Leu   Pro Val Leu 
    27380                 27385                 27390             


Ile Lys   Glu Gln Leu Glu Pro   Pro Glu Ile Asp Met   Lys Asn Phe 
    27395                 27400                 27405             


Pro Ser   His Thr Val Tyr Val   Arg Ala Gly Ser Asn   Leu Lys Val 
    27410                 27415                 27420             


Asp Ile   Pro Ile Ser Gly Lys   Pro Leu Pro Lys Val   Thr Leu Ser 
    27425                 27430                 27435             


Arg Asp   Gly Val Pro Leu Lys   Ala Thr Met Arg Phe   Asn Thr Glu 
    27440                 27445                 27450             


Ile Thr   Ala Glu Asn Leu Thr   Ile Asn Leu Lys Glu   Ser Val Thr 
    27455                 27460                 27465             


Ala Asp   Ala Gly Arg Tyr Glu   Ile Thr Ala Ala Asn   Ser Ser Gly 
    27470                 27475                 27480             


Thr Thr   Lys Ala Phe Ile Asn   Ile Val Val Leu Asp   Arg Pro Gly 
    27485                 27490                 27495             


Pro Pro   Thr Gly Pro Val Val   Ile Ser Asp Ile Thr   Glu Glu Ser 
    27500                 27505                 27510             


Val Thr   Leu Lys Trp Glu Pro   Pro Lys Tyr Asp Gly   Gly Ser Gln 
    27515                 27520                 27525             


Val Thr   Asn Tyr Ile Leu Leu   Lys Arg Glu Thr Ser   Thr Ala Val 
    27530                 27535                 27540             


Trp Thr   Glu Val Ser Ala Thr   Val Ala Arg Thr Met   Met Lys Val 
    27545                 27550                 27555             


Met Lys   Leu Thr Thr Gly Glu   Glu Tyr Gln Phe Arg   Ile Lys Ala 
    27560                 27565                 27570             


Glu Asn   Arg Phe Gly Ile Ser   Asp His Ile Asp Ser   Ala Cys Val 
    27575                 27580                 27585             


Thr Val   Lys Leu Pro Tyr Thr   Thr Pro Gly Pro Pro   Ser Thr Pro 
    27590                 27595                 27600             


Trp Val   Thr Asn Val Thr Arg   Glu Ser Ile Thr Val   Gly Trp His 
    27605                 27610                 27615             


Glu Pro   Val Ser Asn Gly Gly   Ser Ala Val Val Gly   Tyr His Leu 
    27620                 27625                 27630             


Glu Met   Lys Asp Arg Asn Ser   Ile Leu Trp Gln Lys   Ala Asn Lys 
    27635                 27640                 27645             


Leu Val   Ile Arg Thr Thr His   Phe Lys Val Thr Thr   Ile Ser Ala 
    27650                 27655                 27660             


Gly Leu   Ile Tyr Glu Phe Arg   Val Tyr Ala Glu Asn   Ala Ala Gly 
    27665                 27670                 27675             


Val Gly   Lys Pro Ser His Pro   Ser Glu Pro Val Leu   Ala Ile Asp 
    27680                 27685                 27690             


Ala Cys   Glu Pro Pro Arg Asn   Val Arg Ile Thr Asp   Ile Ser Lys 
    27695                 27700                 27705             


Asn Ser   Val Ser Leu Ser Trp   Gln Gln Pro Ala Phe   Asp Gly Gly 
    27710                 27715                 27720             


Ser Lys   Ile Thr Gly Tyr Ile   Val Glu Arg Arg Asp   Leu Pro Asp 
    27725                 27730                 27735             


Gly Arg   Trp Thr Lys Ala Ser   Phe Thr Asn Val Thr   Glu Thr Gln 
    27740                 27745                 27750             


Phe Ile   Ile Ser Gly Leu Thr   Gln Asn Ser Gln Tyr   Glu Phe Arg 
    27755                 27760                 27765             


Val Phe   Ala Arg Asn Ala Val   Gly Ser Ile Ser Asn   Pro Ser Glu 
    27770                 27775                 27780             


Val Val   Gly Pro Ile Thr Cys   Ile Asp Ser Tyr Gly   Gly Pro Val 
    27785                 27790                 27795             


Ile Asp   Leu Pro Leu Glu Tyr   Thr Glu Val Val Lys   Tyr Arg Ala 
    27800                 27805                 27810             


Gly Thr   Ser Val Lys Leu Arg   Ala Gly Ile Ser Gly   Lys Pro Ala 
    27815                 27820                 27825             


Pro Thr   Ile Glu Trp Tyr Lys   Asp Asp Lys Glu Leu   Gln Thr Asn 
    27830                 27835                 27840             


Ala Leu   Val Cys Val Glu Asn   Thr Thr Asp Leu Ala   Ser Ile Leu 
    27845                 27850                 27855             


Ile Lys   Asp Ala Asp Arg Leu   Asn Ser Gly Cys Tyr   Glu Leu Lys 
    27860                 27865                 27870             


Leu Arg   Asn Ala Met Gly Ser   Ala Ser Ala Thr Ile   Arg Val Gln 
    27875                 27880                 27885             


Ile Leu   Asp Lys Pro Gly Pro   Pro Gly Gly Pro Ile   Glu Phe Lys 
    27890                 27895                 27900             


Thr Val   Thr Ala Glu Lys Ile   Thr Leu Leu Trp Arg   Pro Pro Ala 
    27905                 27910                 27915             


Asp Asp   Gly Gly Ala Lys Ile   Thr His Tyr Ile Val   Glu Lys Arg 
    27920                 27925                 27930             


Glu Thr   Ser Arg Val Val Trp   Ser Met Val Ser Glu   His Leu Glu 
    27935                 27940                 27945             


Glu Cys   Ile Ile Thr Thr Thr   Lys Ile Ile Lys Gly   Asn Glu Tyr 
    27950                 27955                 27960             


Ile Phe   Arg Val Arg Ala Val   Asn Lys Tyr Gly Ile   Gly Glu Pro 
    27965                 27970                 27975             


Leu Glu   Ser Asp Ser Val Val   Ala Lys Asn Ala Phe   Val Thr Pro 
    27980                 27985                 27990             


Gly Pro   Pro Gly Ile Pro Glu   Val Thr Lys Ile Thr   Lys Asn Ser 
    27995                 28000                 28005             


Met Thr   Val Val Trp Ser Arg   Pro Ile Ala Asp Gly   Gly Ser Asp 
    28010                 28015                 28020             


Ile Ser   Gly Tyr Phe Leu Glu   Lys Arg Asp Lys Lys   Ser Leu Gly 
    28025                 28030                 28035             


Trp Phe   Lys Val Leu Lys Glu   Thr Ile Arg Asp Thr   Arg Gln Lys 
    28040                 28045                 28050             


Val Thr   Gly Leu Thr Glu Asn   Ser Asp Tyr Gln Tyr   Arg Val Cys 
    28055                 28060                 28065             


Ala Val   Asn Ala Ala Gly Gln   Gly Pro Phe Ser Glu   Pro Ser Glu 
    28070                 28075                 28080             


Phe Tyr   Lys Ala Ala Asp Pro   Ile Asp Pro Pro Gly   Pro Pro Ala 
    28085                 28090                 28095             


Lys Ile   Arg Ile Ala Asp Ser   Thr Lys Ser Ser Ile   Thr Leu Gly 
    28100                 28105                 28110             


Trp Ser   Lys Pro Val Tyr Asp   Gly Gly Ser Ala Val   Thr Gly Tyr 
    28115                 28120                 28125             


Val Val   Glu Ile Arg Gln Gly   Glu Glu Glu Glu Trp   Thr Thr Val 
    28130                 28135                 28140             


Ser Thr   Lys Gly Glu Val Arg   Thr Thr Glu Tyr Val   Val Ser Asn 
    28145                 28150                 28155             


Leu Lys   Pro Gly Val Asn Tyr   Tyr Phe Arg Val Ser   Ala Val Asn 
    28160                 28165                 28170             


Cys Ala   Gly Gln Gly Glu Pro   Ile Glu Met Asn Glu   Pro Val Gln 
    28175                 28180                 28185             


Ala Lys   Asp Ile Leu Glu Ala   Pro Glu Ile Asp Leu   Asp Val Ala 
    28190                 28195                 28200             


Leu Arg   Thr Ser Val Ile Ala   Lys Ala Gly Glu Asp   Val Gln Val 
    28205                 28210                 28215             


Leu Ile   Pro Phe Lys Gly Arg   Pro Pro Pro Thr Val   Thr Trp Arg 
    28220                 28225                 28230             


Lys Asp   Glu Lys Asn Leu Gly   Ser Asp Ala Arg Tyr   Ser Ile Glu 
    28235                 28240                 28245             


Asn Thr   Asp Ser Ser Ser Leu   Leu Thr Ile Pro Gln   Val Thr Arg 
    28250                 28255                 28260             


Asn Asp   Thr Gly Lys Tyr Ile   Leu Thr Ile Glu Asn   Gly Val Gly 
    28265                 28270                 28275             


Glu Pro   Lys Ser Ser Thr Val   Ser Val Lys Val Leu   Asp Thr Pro 
    28280                 28285                 28290             


Ala Ala   Cys Gln Lys Leu Gln   Val Lys His Val Ser   Arg Gly Thr 
    28295                 28300                 28305             


Val Thr   Leu Leu Trp Asp Pro   Pro Leu Ile Asp Gly   Gly Ser Pro 
    28310                 28315                 28320             


Ile Ile   Asn Tyr Val Ile Glu   Lys Arg Asp Ala Thr   Lys Arg Thr 
    28325                 28330                 28335             


Trp Ser   Val Val Ser His Lys   Cys Ser Ser Thr Ser   Phe Lys Leu 
    28340                 28345                 28350             


Ile Asp   Leu Ser Glu Lys Thr   Pro Phe Phe Phe Arg   Val Leu Ala 
    28355                 28360                 28365             


Glu Asn   Glu Ile Gly Ile Gly   Glu Pro Cys Glu Thr   Thr Glu Pro 
    28370                 28375                 28380             


Val Lys   Ala Ala Glu Val Pro   Ala Pro Ile Arg Asp   Leu Ser Met 
    28385                 28390                 28395             


Lys Asp   Ser Thr Lys Thr Ser   Val Ile Leu Ser Trp   Thr Lys Pro 
    28400                 28405                 28410             


Asp Phe   Asp Gly Gly Ser Val   Ile Thr Glu Tyr Val   Val Glu Arg 
    28415                 28420                 28425             


Lys Gly   Lys Gly Glu Gln Thr   Trp Ser His Ala Gly   Ile Ser Lys 
    28430                 28435                 28440             


Thr Cys   Glu Ile Glu Val Ser   Gln Leu Lys Glu Gln   Ser Val Leu 
    28445                 28450                 28455             


Glu Phe   Arg Val Phe Ala Lys   Asn Glu Lys Gly Leu   Ser Asp Pro 
    28460                 28465                 28470             


Val Thr   Ile Gly Pro Ile Thr   Val Lys Glu Leu Ile   Ile Thr Pro 
    28475                 28480                 28485             


Glu Val   Asp Leu Ser Asp Ile   Pro Gly Ala Gln Val   Thr Val Arg 
    28490                 28495                 28500             


Ile Gly   His Asn Val His Leu   Glu Leu Pro Tyr Lys   Gly Lys Pro 
    28505                 28510                 28515             


Lys Pro   Ser Ile Ser Trp Leu   Lys Asp Gly Leu Pro   Leu Lys Glu 
    28520                 28525                 28530             


Ser Glu   Phe Val Arg Phe Ser   Lys Thr Glu Asn Lys   Ile Thr Leu 
    28535                 28540                 28545             


Ser Ile   Lys Asn Ala Lys Lys   Glu His Gly Gly Lys   Tyr Thr Val 
    28550                 28555                 28560             


Ile Leu   Asp Asn Ala Val Cys   Arg Ile Ala Val Pro   Ile Thr Val 
    28565                 28570                 28575             


Ile Thr   Leu Gly Pro Pro Ser   Lys Pro Lys Gly Pro   Ile Arg Phe 
    28580                 28585                 28590             


Asp Glu   Ile Lys Ala Asp Ser   Val Ile Leu Ser Trp   Asp Val Pro 
    28595                 28600                 28605             


Glu Asp   Asn Gly Gly Gly Glu   Ile Thr Cys Tyr Ser   Ile Glu Lys 
    28610                 28615                 28620             


Arg Glu   Thr Ser Gln Thr Asn   Trp Lys Met Val Cys   Ser Ser Val 
    28625                 28630                 28635             


Ala Arg   Thr Thr Phe Lys Val   Pro Asn Leu Val Lys   Asp Ala Glu 
    28640                 28645                 28650             


Tyr Gln   Phe Arg Val Arg Ala   Glu Asn Arg Tyr Gly   Val Ser Gln 
    28655                 28660                 28665             


Pro Leu   Val Ser Ser Ile Ile   Val Ala Lys His Gln   Phe Arg Ile 
    28670                 28675                 28680             


Pro Gly   Pro Pro Gly Lys Pro   Val Ile Tyr Asn Val   Thr Ser Asp 
    28685                 28690                 28695             


Gly Met   Ser Leu Thr Trp Asp   Ala Pro Val Tyr Asp   Gly Gly Ser 
    28700                 28705                 28710             


Glu Val   Thr Gly Phe His Val   Glu Lys Lys Glu Arg   Asn Ser Ile 
    28715                 28720                 28725             


Leu Trp   Gln Lys Val Asn Thr   Ser Pro Ile Ser Gly   Arg Glu Tyr 
    28730                 28735                 28740             


Arg Ala   Thr Gly Leu Val Glu   Gly Leu Asp Tyr Gln   Phe Arg Val 
    28745                 28750                 28755             


Tyr Ala   Glu Asn Ser Ala Gly   Leu Ser Ser Pro Ser   Asp Pro Ser 
    28760                 28765                 28770             


Lys Phe   Thr Leu Ala Val Ser   Pro Val Asp Pro Pro   Gly Thr Pro 
    28775                 28780                 28785             


Asp Tyr   Ile Asp Val Thr Arg   Glu Thr Ile Thr Leu   Lys Trp Asn 
    28790                 28795                 28800             


Pro Pro   Leu Arg Asp Gly Gly   Ser Lys Ile Val Gly   Tyr Ser Ile 
    28805                 28810                 28815             


Glu Lys   Arg Gln Gly Asn Glu   Arg Trp Val Arg Cys   Asn Phe Thr 
    28820                 28825                 28830             


Asp Val   Ser Glu Cys Gln Tyr   Thr Val Thr Gly Leu   Ser Pro Gly 
    28835                 28840                 28845             


Asp Arg   Tyr Glu Phe Arg Ile   Ile Ala Arg Asn Ala   Val Gly Thr 
    28850                 28855                 28860             


Ile Ser   Pro Pro Ser Gln Ser   Ser Gly Ile Ile Met   Thr Arg Asp 
    28865                 28870                 28875             


Glu Asn   Val Pro Pro Ile Val   Glu Phe Gly Pro Glu   Tyr Phe Asp 
    28880                 28885                 28890             


Gly Leu   Ile Ile Lys Ser Gly   Glu Ser Leu Arg Ile   Lys Ala Leu 
    28895                 28900                 28905             


Val Gln   Gly Arg Pro Val Pro   Arg Val Thr Trp Phe   Lys Asp Gly 
    28910                 28915                 28920             


Val Glu   Ile Glu Lys Arg Met   Asn Met Glu Ile Thr   Asp Val Leu 
    28925                 28930                 28935             


Gly Ser   Thr Ser Leu Phe Val   Arg Asp Ala Thr Arg   Asp His Arg 
    28940                 28945                 28950             


Gly Val   Tyr Thr Val Glu Ala   Lys Asn Ala Ser Gly   Ser Ala Lys 
    28955                 28960                 28965             


Ala Glu   Ile Lys Val Lys Val   Gln Asp Thr Pro Gly   Lys Val Val 
    28970                 28975                 28980             


Gly Pro   Ile Arg Phe Thr Asn   Ile Thr Gly Glu Lys   Met Thr Leu 
    28985                 28990                 28995             


Trp Trp   Asp Ala Pro Leu Asn   Asp Gly Cys Ala Pro   Ile Thr His 
    29000                 29005                 29010             


Tyr Ile   Ile Glu Lys Arg Glu   Thr Ser Arg Leu Ala   Trp Ala Leu 
    29015                 29020                 29025             


Ile Glu   Asp Lys Cys Glu Ala   Gln Ser Tyr Thr Ala   Ile Lys Leu 
    29030                 29035                 29040             


Ile Asn   Gly Asn Glu Tyr Gln   Phe Arg Val Ser Ala   Val Asn Lys 
    29045                 29050                 29055             


Phe Gly   Val Gly Arg Pro Leu   Asp Ser Asp Pro Val   Val Ala Gln 
    29060                 29065                 29070             


Ile Gln   Tyr Thr Val Pro Asp   Ala Pro Gly Ile Pro   Glu Pro Ser 
    29075                 29080                 29085             


Asn Ile   Thr Gly Asn Ser Ile   Thr Leu Thr Trp Ala   Arg Pro Glu 
    29090                 29095                 29100             


Ser Asp   Gly Gly Ser Glu Ile   Gln Gln Tyr Ile Leu   Glu Arg Arg 
    29105                 29110                 29115             


Glu Lys   Lys Ser Thr Arg Trp   Val Lys Val Ile Ser   Lys Arg Pro 
    29120                 29125                 29130             


Ile Ser   Glu Thr Arg Phe Lys   Val Thr Gly Leu Thr   Glu Gly Asn 
    29135                 29140                 29145             


Glu Tyr   Glu Phe His Val Met   Ala Glu Asn Ala Ala   Gly Val Gly 
    29150                 29155                 29160             


Pro Ala   Ser Gly Ile Ser Arg   Leu Ile Lys Cys Arg   Glu Pro Val 
    29165                 29170                 29175             


Asn Pro   Pro Gly Pro Pro Thr   Val Val Lys Val Thr   Asp Thr Ser 
    29180                 29185                 29190             


Lys Thr   Thr Val Ser Leu Glu   Trp Ser Lys Pro Val   Phe Asp Gly 
    29195                 29200                 29205             


Gly Met   Glu Ile Ile Gly Tyr   Ile Ile Glu Met Cys   Lys Ala Asp 
    29210                 29215                 29220             


Leu Gly   Asp Trp His Lys Val   Asn Ala Glu Ala Cys   Val Lys Thr 
    29225                 29230                 29235             


Arg Tyr   Thr Val Thr Asp Leu   Gln Ala Gly Glu Glu   Tyr Lys Phe 
    29240                 29245                 29250             


Arg Val   Ser Ala Ile Asn Gly   Ala Gly Lys Gly Asp   Ser Cys Glu 
    29255                 29260                 29265             


Val Thr   Gly Thr Ile Lys Ala   Val Asp Arg Leu Thr   Ala Pro Glu 
    29270                 29275                 29280             


Leu Asp   Ile Asp Ala Asn Phe   Lys Gln Thr His Val   Val Arg Ala 
    29285                 29290                 29295             


Gly Ala   Ser Ile Arg Leu Phe   Ile Ala Tyr Gln Gly   Arg Pro Thr 
    29300                 29305                 29310             


Pro Thr   Ala Val Trp Ser Lys   Pro Asp Ser Asn Leu   Ser Leu Arg 
    29315                 29320                 29325             


Ala Asp   Ile His Thr Thr Asp   Ser Phe Ser Thr Leu   Thr Val Glu 
    29330                 29335                 29340             


Asn Cys   Asn Arg Asn Asp Ala   Gly Lys Tyr Thr Leu   Thr Val Glu 
    29345                 29350                 29355             


Asn Asn   Ser Gly Ser Lys Ser   Ile Thr Phe Thr Val   Lys Val Leu 
    29360                 29365                 29370             


Asp Thr   Pro Gly Pro Pro Gly   Pro Ile Thr Phe Lys   Asp Val Thr 
    29375                 29380                 29385             


Arg Gly   Ser Ala Thr Leu Met   Trp Asp Ala Pro Leu   Leu Asp Gly 
    29390                 29395                 29400             


Gly Ala   Arg Ile His His Tyr   Val Val Glu Lys Arg   Glu Ala Ser 
    29405                 29410                 29415             


Arg Arg   Ser Trp Gln Val Ile   Ser Glu Lys Cys Thr   Arg Gln Ile 
    29420                 29425                 29430             


Phe Lys   Val Asn Asp Leu Ala   Glu Gly Val Pro Tyr   Tyr Phe Arg 
    29435                 29440                 29445             


Val Ser   Ala Val Asn Glu Tyr   Gly Val Gly Glu Pro   Tyr Glu Met 
    29450                 29455                 29460             


Pro Glu   Pro Ile Val Ala Thr   Glu Gln Pro Ala Pro   Pro Arg Arg 
    29465                 29470                 29475             


Leu Asp   Val Val Asp Thr Ser   Lys Ser Ser Ala Val   Leu Ala Trp 
    29480                 29485                 29490             


Leu Lys   Pro Asp His Asp Gly   Gly Ser Arg Ile Thr   Gly Tyr Leu 
    29495                 29500                 29505             


Leu Glu   Met Arg Gln Lys Gly   Ser Asp Phe Trp Val   Glu Ala Gly 
    29510                 29515                 29520             


His Thr   Lys Gln Leu Thr Phe   Thr Val Glu Arg Leu   Val Glu Lys 
    29525                 29530                 29535             


Thr Glu   Tyr Glu Phe Arg Val   Lys Ala Lys Asn Asp   Ala Gly Tyr 
    29540                 29545                 29550             


Ser Glu   Pro Arg Glu Ala Phe   Ser Ser Val Ile Ile   Lys Glu Pro 
    29555                 29560                 29565             


Gln Ile   Glu Pro Thr Ala Asp   Leu Thr Gly Ile Thr   Asn Gln Leu 
    29570                 29575                 29580             


Ile Thr   Cys Lys Ala Gly Ser   Pro Phe Thr Ile Asp   Val Pro Ile 
    29585                 29590                 29595             


Ser Gly   Arg Pro Ala Pro Lys   Val Thr Trp Lys Leu   Glu Glu Met 
    29600                 29605                 29610             


Arg Leu   Lys Glu Thr Asp Arg   Val Ser Ile Thr Thr   Thr Lys Asp 
    29615                 29620                 29625             


Arg Thr   Thr Leu Thr Val Lys   Asp Ser Met Arg Gly   Asp Ser Gly 
    29630                 29635                 29640             


Arg Tyr   Phe Leu Thr Leu Glu   Asn Thr Ala Gly Val   Lys Thr Phe 
    29645                 29650                 29655             


Ser Val   Thr Val Val Val Ile   Gly Arg Pro Gly Pro   Val Thr Gly 
    29660                 29665                 29670             


Pro Ile   Glu Val Ser Ser Val   Ser Ala Glu Ser Cys   Val Leu Ser 
    29675                 29680                 29685             


Trp Gly   Glu Pro Lys Asp Gly   Gly Gly Thr Glu Ile   Thr Asn Tyr 
    29690                 29695                 29700             


Ile Val   Glu Lys Arg Glu Ser   Gly Thr Thr Ala Trp   Gln Leu Val 
    29705                 29710                 29715             


Asn Ser   Ser Val Lys Arg Thr   Gln Ile Lys Val Thr   His Leu Thr 
    29720                 29725                 29730             


Lys Tyr   Met Glu Tyr Ser Phe   Arg Val Ser Ser Glu   Asn Arg Phe 
    29735                 29740                 29745             


Gly Val   Ser Lys Pro Leu Glu   Ser Ala Pro Ile Ile   Ala Glu His 
    29750                 29755                 29760             


Pro Phe   Val Pro Pro Ser Ala   Pro Thr Arg Pro Glu   Val Tyr His 
    29765                 29770                 29775             


Val Ser   Ala Asn Ala Met Ser   Ile Arg Trp Glu Glu   Pro Tyr His 
    29780                 29785                 29790             


Asp Gly   Gly Ser Lys Ile Ile   Gly Tyr Trp Val Glu   Lys Lys Glu 
    29795                 29800                 29805             


Arg Asn   Thr Ile Leu Trp Val   Lys Glu Asn Lys Val   Pro Cys Leu 
    29810                 29815                 29820             


Glu Cys   Asn Tyr Lys Val Thr   Gly Leu Val Glu Gly   Leu Glu Tyr 
    29825                 29830                 29835             


Gln Phe   Arg Thr Tyr Ala Leu   Asn Ala Ala Gly Val   Ser Lys Ala 
    29840                 29845                 29850             


Ser Glu   Ala Ser Arg Pro Ile   Met Ala Gln Asn Pro   Val Asp Ala 
    29855                 29860                 29865             


Pro Gly   Arg Pro Glu Val Thr   Asp Val Thr Arg Ser   Thr Val Ser 
    29870                 29875                 29880             


Leu Ile   Trp Ser Ala Pro Ala   Tyr Asp Gly Gly Ser   Lys Val Val 
    29885                 29890                 29895             


Gly Tyr   Ile Ile Glu Arg Lys   Pro Val Ser Glu Val   Gly Asp Gly 
    29900                 29905                 29910             


Arg Trp   Leu Lys Cys Asn Tyr   Thr Ile Val Ser Asp   Asn Phe Phe 
    29915                 29920                 29925             


Thr Val   Thr Ala Leu Ser Glu   Gly Asp Thr Tyr Glu   Phe Arg Val 
    29930                 29935                 29940             


Leu Ala   Lys Asn Ala Ala Gly   Val Ile Ser Lys Gly   Ser Glu Ser 
    29945                 29950                 29955             


Thr Gly   Pro Val Thr Cys Arg   Asp Glu Tyr Ala Pro   Pro Lys Ala 
    29960                 29965                 29970             


Glu Leu   Asp Ala Arg Leu His   Gly Asp Leu Val Thr   Ile Arg Ala 
    29975                 29980                 29985             


Gly Ser   Asp Leu Val Leu Asp   Ala Ala Val Gly Gly   Lys Pro Glu 
    29990                 29995                 30000             


Pro Lys   Ile Ile Trp Thr Lys   Gly Asp Lys Glu Leu   Asp Leu Cys 
    30005                 30010                 30015             


Glu Lys   Val Ser Leu Gln Tyr   Thr Gly Lys Arg Ala   Thr Ala Val 
    30020                 30025                 30030             


Ile Lys   Phe Cys Asp Arg Ser   Asp Ser Gly Lys Tyr   Thr Leu Thr 
    30035                 30040                 30045             


Val Lys   Asn Ala Ser Gly Thr   Lys Ala Val Ser Val   Met Val Lys 
    30050                 30055                 30060             


Val Leu   Asp Ser Pro Gly Pro   Cys Gly Lys Leu Thr   Val Ser Arg 
    30065                 30070                 30075             


Val Thr   Gln Glu Lys Cys Thr   Leu Ala Trp Ser Leu   Pro Gln Glu 
    30080                 30085                 30090             


Asp Gly   Gly Ala Glu Ile Thr   His Tyr Ile Val Glu   Arg Arg Glu 
    30095                 30100                 30105             


Thr Ser   Arg Leu Asn Trp Val   Ile Val Glu Gly Glu   Cys Pro Thr 
    30110                 30115                 30120             


Leu Ser   Tyr Val Val Thr Arg   Leu Ile Lys Asn Asn   Glu Tyr Ile 
    30125                 30130                 30135             


Phe Arg   Val Arg Ala Val Asn   Lys Tyr Gly Pro Gly   Val Pro Val 
    30140                 30145                 30150             


Glu Ser   Glu Pro Ile Val Ala   Arg Asn Ser Phe Thr   Ile Pro Ser 
    30155                 30160                 30165             


Pro Pro   Gly Ile Pro Glu Glu   Val Gly Thr Gly Lys   Glu His Ile 
    30170                 30175                 30180             


Ile Ile   Gln Trp Thr Lys Pro   Glu Ser Asp Gly Gly   Asn Glu Ile 
    30185                 30190                 30195             


Ser Asn   Tyr Leu Val Asp Lys   Arg Glu Lys Lys Ser   Leu Arg Trp 
    30200                 30205                 30210             


Thr Arg   Val Asn Lys Asp Tyr   Val Val Tyr Asp Thr   Arg Leu Lys 
    30215                 30220                 30225             


Val Thr   Ser Leu Met Glu Gly   Cys Asp Tyr Gln Phe   Arg Val Thr 
    30230                 30235                 30240             


Ala Val   Asn Ala Ala Gly Asn   Ser Glu Pro Ser Glu   Ala Ser Asn 
    30245                 30250                 30255             


Phe Ile   Ser Cys Arg Glu Pro   Ser Tyr Thr Pro Gly   Pro Pro Ser 
    30260                 30265                 30270             


Ala Pro   Arg Val Val Asp Thr   Thr Lys His Ser Ile   Ser Leu Ala 
    30275                 30280                 30285             


Trp Thr   Lys Pro Met Tyr Asp   Gly Gly Thr Asp Ile   Val Gly Tyr 
    30290                 30295                 30300             


Val Leu   Glu Met Gln Glu Lys   Asp Thr Asp Gln Trp   Tyr Arg Val 
    30305                 30310                 30315             


His Thr   Asn Ala Thr Ile Arg   Asn Thr Glu Phe Thr   Val Pro Asp 
    30320                 30325                 30330             


Leu Lys   Met Gly Gln Lys Tyr   Ser Phe Arg Val Ala   Ala Val Asn 
    30335                 30340                 30345             


Val Lys   Gly Met Ser Glu Tyr   Ser Glu Ser Ile Ala   Glu Ile Glu 
    30350                 30355                 30360             


Pro Val   Glu Arg Ile Glu Ile   Pro Asp Leu Glu Leu   Ala Asp Asp 
    30365                 30370                 30375             


Leu Lys   Lys Thr Val Thr Ile   Arg Ala Gly Ala Ser   Leu Arg Leu 
    30380                 30385                 30390             


Met Val   Ser Val Ser Gly Arg   Pro Pro Pro Val Ile   Thr Trp Ser 
    30395                 30400                 30405             


Lys Gln   Gly Ile Asp Leu Ala   Ser Arg Ala Ile Ile   Asp Thr Thr 
    30410                 30415                 30420             


Glu Ser   Tyr Ser Leu Leu Ile   Val Asp Lys Val Asn   Arg Tyr Asp 
    30425                 30430                 30435             


Ala Gly   Lys Tyr Thr Ile Glu   Ala Glu Asn Gln Ser   Gly Lys Lys 
    30440                 30445                 30450             


Ser Ala   Thr Val Leu Val Lys   Val Tyr Asp Thr Pro   Gly Pro Cys 
    30455                 30460                 30465             


Pro Ser   Val Lys Val Lys Glu   Val Ser Arg Asp Ser   Val Thr Ile 
    30470                 30475                 30480             


Thr Trp   Glu Ile Pro Thr Ile   Asp Gly Gly Ala Pro   Val Asn Asn 
    30485                 30490                 30495             


Tyr Ile   Val Glu Lys Arg Glu   Ala Ala Met Arg Ala   Phe Lys Thr 
    30500                 30505                 30510             


Val Thr   Thr Lys Cys Ser Lys   Thr Leu Tyr Arg Ile   Ser Gly Leu 
    30515                 30520                 30525             


Val Glu   Gly Thr Met Tyr Tyr   Phe Arg Val Leu Pro   Glu Asn Ile 
    30530                 30535                 30540             


Tyr Gly   Ile Gly Glu Pro Cys   Glu Thr Ser Asp Ala   Val Leu Val 
    30545                 30550                 30555             


Ser Glu   Val Pro Leu Val Pro   Ala Lys Leu Glu Val   Val Asp Val 
    30560                 30565                 30570             


Thr Lys   Ser Thr Val Thr Leu   Ala Trp Glu Lys Pro   Leu Tyr Asp 
    30575                 30580                 30585             


Gly Gly   Ser Arg Leu Thr Gly   Tyr Val Leu Glu Ala   Cys Lys Ala 
    30590                 30595                 30600             


Gly Thr   Glu Arg Trp Met Lys   Val Val Thr Leu Lys   Pro Thr Val 
    30605                 30610                 30615             


Leu Glu   His Thr Val Thr Ser   Leu Asn Glu Gly Glu   Gln Tyr Leu 
    30620                 30625                 30630             


Phe Arg   Ile Arg Ala Gln Asn   Glu Lys Gly Val Ser   Glu Pro Arg 
    30635                 30640                 30645             


Glu Thr   Val Thr Ala Val Thr   Val Gln Asp Leu Arg   Val Leu Pro 
    30650                 30655                 30660             


Thr Ile   Asp Leu Ser Thr Met   Pro Gln Lys Thr Ile   His Val Pro 
    30665                 30670                 30675             


Ala Gly   Arg Pro Val Glu Leu   Val Ile Pro Ile Ala   Gly Arg Pro 
    30680                 30685                 30690             


Pro Pro   Ala Ala Ser Trp Phe   Phe Ala Gly Ser Lys   Leu Arg Glu 
    30695                 30700                 30705             


Ser Glu   Arg Val Thr Val Glu   Thr His Thr Lys Val   Ala Lys Leu 
    30710                 30715                 30720             


Thr Ile   Arg Glu Thr Thr Ile   Arg Asp Thr Gly Glu   Tyr Thr Leu 
    30725                 30730                 30735             


Glu Leu   Lys Asn Val Thr Gly   Thr Thr Ser Glu Thr   Ile Lys Val 
    30740                 30745                 30750             


Ile Ile   Leu Asp Lys Pro Gly   Pro Pro Thr Gly Pro   Ile Lys Ile 
    30755                 30760                 30765             


Asp Glu   Ile Asp Ala Thr Ser   Ile Thr Ile Ser Trp   Glu Pro Pro 
    30770                 30775                 30780             


Glu Leu   Asp Gly Gly Ala Pro   Leu Ser Gly Tyr Val   Val Glu Gln 
    30785                 30790                 30795             


Arg Asp   Ala His Arg Pro Gly   Trp Leu Pro Val Ser   Glu Ser Val 
    30800                 30805                 30810             


Thr Arg   Ser Thr Phe Lys Phe   Thr Arg Leu Thr Glu   Gly Asn Glu 
    30815                 30820                 30825             


Tyr Val   Phe Arg Val Ala Ala   Thr Asn Arg Phe Gly   Ile Gly Ser 
    30830                 30835                 30840             


Tyr Leu   Gln Ser Glu Val Ile   Glu Cys Arg Ser Ser   Ile Arg Ile 
    30845                 30850                 30855             


Pro Gly   Pro Pro Glu Thr Leu   Gln Ile Phe Asp Val   Ser Arg Asp 
    30860                 30865                 30870             


Gly Met   Thr Leu Thr Trp Tyr   Pro Pro Glu Asp Asp   Gly Gly Ser 
    30875                 30880                 30885             


Gln Val   Thr Gly Tyr Ile Val   Glu Arg Lys Glu Val   Arg Ala Asp 
    30890                 30895                 30900             


Arg Trp   Val Arg Val Asn Lys   Val Pro Val Thr Met   Thr Arg Tyr 
    30905                 30910                 30915             


Arg Ser   Thr Gly Leu Thr Glu   Gly Leu Glu Tyr Glu   His Arg Val 
    30920                 30925                 30930             


Thr Ala   Ile Asn Ala Arg Gly   Ser Gly Lys Pro Ser   Arg Pro Ser 
    30935                 30940                 30945             


Lys Pro   Ile Val Ala Met Asp   Pro Ile Ala Pro Pro   Gly Lys Pro 
    30950                 30955                 30960             


Gln Asn   Pro Arg Val Thr Asp   Thr Thr Arg Thr Ser   Val Ser Leu 
    30965                 30970                 30975             


Ala Trp   Ser Val Pro Glu Asp   Glu Gly Gly Ser Lys   Val Thr Gly 
    30980                 30985                 30990             


Tyr Leu   Ile Glu Met Gln Lys   Val Asp Gln His Glu   Trp Thr Lys 
    30995                 31000                 31005             


Cys Asn   Thr Thr Pro Thr Lys   Ile Arg Glu Tyr Thr   Leu Thr His 
    31010                 31015                 31020             


Leu Pro   Gln Gly Ala Glu Tyr   Arg Phe Arg Val Leu   Ala Cys Asn 
    31025                 31030                 31035             


Ala Gly   Gly Pro Gly Glu Pro   Ala Glu Val Pro Gly   Thr Val Lys 
    31040                 31045                 31050             


Val Thr   Glu Met Leu Glu Tyr   Pro Asp Tyr Glu Leu   Asp Glu Arg 
    31055                 31060                 31065             


Tyr Gln   Glu Gly Ile Phe Val   Arg Gln Gly Gly Val   Ile Arg Leu 
    31070                 31075                 31080             


Thr Ile   Pro Ile Lys Gly Lys   Pro Phe Pro Ile Cys   Lys Trp Thr 
    31085                 31090                 31095             


Lys Glu   Gly Gln Asp Ile Ser   Lys Arg Ala Met Ile   Ala Thr Ser 
    31100                 31105                 31110             


Glu Thr   His Thr Glu Leu Val   Ile Lys Glu Ala Asp   Arg Gly Asp 
    31115                 31120                 31125             


Ser Gly   Thr Tyr Asp Leu Val   Leu Glu Asn Lys Cys   Gly Lys Lys 
    31130                 31135                 31140             


Ala Val   Tyr Ile Lys Val Arg   Val Ile Gly Ser Pro   Asn Ser Pro 
    31145                 31150                 31155             


Glu Gly   Pro Leu Glu Tyr Asp   Asp Ile Gln Val Arg   Ser Val Arg 
    31160                 31165                 31170             


Val Ser   Trp Arg Pro Pro Ala   Asp Asp Gly Gly Ala   Asp Ile Leu 
    31175                 31180                 31185             


Gly Tyr   Ile Leu Glu Arg Arg   Glu Val Pro Lys Ala   Ala Trp Tyr 
    31190                 31195                 31200             


Thr Ile   Asp Ser Arg Val Arg   Gly Thr Ser Leu Val   Val Lys Gly 
    31205                 31210                 31215             


Leu Lys   Glu Asn Val Glu Tyr   His Phe Arg Val Ser   Ala Glu Asn 
    31220                 31225                 31230             


Gln Phe   Gly Ile Ser Lys Pro   Leu Lys Ser Glu Glu   Pro Val Thr 
    31235                 31240                 31245             


Pro Lys   Thr Pro Leu Asn Pro   Pro Glu Pro Pro Ser   Asn Pro Pro 
    31250                 31255                 31260             


Glu Val   Leu Asp Val Thr Lys   Ser Ser Val Ser Leu   Ser Trp Ser 
    31265                 31270                 31275             


Arg Pro   Lys Asp Asp Gly Gly   Ser Arg Val Thr Gly   Tyr Tyr Ile 
    31280                 31285                 31290             


Glu Arg   Lys Glu Thr Ser Thr   Asp Lys Trp Val Arg   His Asn Lys 
    31295                 31300                 31305             


Thr Gln   Ile Thr Thr Thr Met   Tyr Thr Val Thr Gly   Leu Val Pro 
    31310                 31315                 31320             


Asp Ala   Glu Tyr Gln Phe Arg   Ile Ile Ala Gln Asn   Asp Val Gly 
    31325                 31330                 31335             


Leu Ser   Glu Thr Ser Pro Ala   Ser Glu Pro Val Val   Cys Lys Asp 
    31340                 31345                 31350             


Pro Phe   Asp Lys Pro Ser Gln   Pro Gly Glu Leu Glu   Ile Leu Ser 
    31355                 31360                 31365             


Ile Ser   Lys Asp Ser Val Thr   Leu Gln Trp Glu Lys   Pro Glu Cys 
    31370                 31375                 31380             


Asp Gly   Gly Lys Glu Ile Leu   Gly Tyr Trp Val Glu   Tyr Arg Gln 
    31385                 31390                 31395             


Ser Gly   Asp Ser Ala Trp Lys   Lys Ser Asn Lys Glu   Arg Ile Lys 
    31400                 31405                 31410             


Asp Lys   Gln Phe Thr Ile Gly   Gly Leu Leu Glu Ala   Thr Glu Tyr 
    31415                 31420                 31425             


Glu Phe   Arg Val Phe Ala Glu   Asn Glu Thr Gly Leu   Ser Arg Pro 
    31430                 31435                 31440             


Arg Arg   Thr Ala Met Ser Ile   Lys Thr Lys Leu Thr   Ser Gly Glu 
    31445                 31450                 31455             


Ala Pro   Gly Ile Arg Lys Glu   Met Lys Asp Val Thr   Thr Lys Leu 
    31460                 31465                 31470             


Gly Glu   Ala Ala Gln Leu Ser   Cys Gln Ile Val Gly   Arg Pro Leu 
    31475                 31480                 31485             


Pro Asp   Ile Lys Trp Tyr Arg   Phe Gly Lys Glu Leu   Ile Gln Ser 
    31490                 31495                 31500             


Arg Lys   Tyr Lys Met Ser Ser   Asp Gly Arg Thr His   Thr Leu Thr 
    31505                 31510                 31515             


Val Met   Thr Glu Glu Gln Glu   Asp Glu Gly Val Tyr   Thr Cys Ile 
    31520                 31525                 31530             


Ala Thr   Asn Glu Val Gly Glu   Val Glu Thr Ser Ser   Lys Leu Leu 
    31535                 31540                 31545             


Leu Gln   Ala Thr Pro Gln Phe   His Pro Gly Tyr Pro   Leu Lys Glu 
    31550                 31555                 31560             


Lys Tyr   Tyr Gly Ala Val Gly   Ser Thr Leu Arg Leu   His Val Met 
    31565                 31570                 31575             


Tyr Ile   Gly Arg Pro Val Pro   Ala Met Thr Trp Phe   His Gly Gln 
    31580                 31585                 31590             


Lys Leu   Leu Gln Asn Ser Glu   Asn Ile Thr Ile Glu   Asn Thr Glu 
    31595                 31600                 31605             


His Tyr   Thr His Leu Val Met   Lys Asn Val Gln Arg   Lys Thr His 
    31610                 31615                 31620             


Ala Gly   Lys Tyr Lys Val Gln   Leu Ser Asn Val Phe   Gly Thr Val 
    31625                 31630                 31635             


Asp Ala   Ile Leu Asp Val Glu   Ile Gln Asp Lys Pro   Asp Lys Pro 
    31640                 31645                 31650             


Thr Gly   Pro Ile Val Ile Glu   Ala Leu Leu Lys Asn   Ser Ala Val 
    31655                 31660                 31665             


Ile Ser   Trp Lys Pro Pro Ala   Asp Asp Gly Gly Ser   Trp Ile Thr 
    31670                 31675                 31680             


Asn Tyr   Val Val Glu Lys Cys   Glu Ala Lys Glu Gly   Ala Glu Trp 
    31685                 31690                 31695             


Gln Leu   Val Ser Ser Ala Ile   Ser Val Thr Thr Cys   Arg Ile Val 
    31700                 31705                 31710             


Asn Leu   Thr Glu Asn Ala Gly   Tyr Tyr Phe Arg Val   Ser Ala Gln 
    31715                 31720                 31725             


Asn Thr   Phe Gly Ile Ser Asp   Pro Leu Glu Val Ser   Ser Val Val 
    31730                 31735                 31740             


Ile Ile   Lys Ser Pro Phe Glu   Lys Pro Gly Ala Pro   Gly Lys Pro 
    31745                 31750                 31755             


Thr Ile   Thr Ala Val Thr Lys   Asp Ser Cys Val Val   Ala Trp Lys 
    31760                 31765                 31770             


Pro Pro   Ala Ser Asp Gly Gly   Ala Lys Ile Arg Asn   Tyr Tyr Leu 
    31775                 31780                 31785             


Glu Lys   Arg Glu Lys Lys Gln   Asn Lys Trp Ile Ser   Val Thr Thr 
    31790                 31795                 31800             


Glu Glu   Ile Arg Glu Thr Val   Phe Ser Val Lys Asn   Leu Ile Glu 
    31805                 31810                 31815             


Gly Leu   Glu Tyr Glu Phe Arg   Val Lys Cys Glu Asn   Leu Gly Gly 
    31820                 31825                 31830             


Glu Ser   Glu Trp Ser Glu Ile   Ser Glu Pro Ile Thr   Pro Lys Ser 
    31835                 31840                 31845             


Asp Val   Pro Ile Gln Ala Pro   His Phe Lys Glu Glu   Leu Arg Asn 
    31850                 31855                 31860             


Leu Asn   Val Arg Tyr Gln Ser   Asn Ala Thr Leu Val   Cys Lys Val 
    31865                 31870                 31875             


Thr Gly   His Pro Lys Pro Ile   Val Lys Trp Tyr Arg   Gln Gly Lys 
    31880                 31885                 31890             


Glu Ile   Ile Ala Asp Gly Leu   Lys Tyr Arg Ile Gln   Glu Phe Lys 
    31895                 31900                 31905             


Gly Gly   Tyr His Gln Leu Ile   Ile Ala Ser Val Thr   Asp Asp Asp 
    31910                 31915                 31920             


Ala Thr   Val Tyr Gln Val Arg   Ala Thr Asn Gln Gly   Gly Ser Val 
    31925                 31930                 31935             


Ser Gly   Thr Ala Ser Leu Glu   Val Glu Val Pro Ala   Lys Ile His 
    31940                 31945                 31950             


Leu Pro   Lys Thr Leu Glu Gly   Met Gly Ala Val His   Ala Leu Arg 
    31955                 31960                 31965             


Gly Glu   Val Val Ser Ile Lys   Ile Pro Phe Ser Gly   Lys Pro Asp 
    31970                 31975                 31980             


Pro Val   Ile Thr Trp Gln Lys   Gly Gln Asp Leu Ile   Asp Asn Asn 
    31985                 31990                 31995             


Gly His   Tyr Gln Val Ile Val   Thr Arg Ser Phe Thr   Ser Leu Val 
    32000                 32005                 32010             


Phe Pro   Asn Gly Val Glu Arg   Lys Asp Ala Gly Phe   Tyr Val Val 
    32015                 32020                 32025             


Cys Ala   Lys Asn Arg Phe Gly   Ile Asp Gln Lys Thr   Val Glu Leu 
    32030                 32035                 32040             


Asp Val   Ala Asp Val Pro Asp   Pro Pro Arg Gly Val   Lys Val Ser 
    32045                 32050                 32055             


Asp Val   Ser Arg Asp Ser Val   Asn Leu Thr Trp Thr   Glu Pro Ala 
    32060                 32065                 32070             


Ser Asp   Gly Gly Ser Lys Ile   Thr Asn Tyr Ile Val   Glu Lys Cys 
    32075                 32080                 32085             


Ala Thr   Thr Ala Glu Arg Trp   Leu Arg Val Gly Gln   Ala Arg Glu 
    32090                 32095                 32100             


Thr Arg   Tyr Thr Val Ile Asn   Leu Phe Gly Lys Thr   Ser Tyr Gln 
    32105                 32110                 32115             


Phe Arg   Val Ile Ala Glu Asn   Lys Phe Gly Leu Ser   Lys Pro Ser 
    32120                 32125                 32130             


Glu Pro   Ser Glu Pro Thr Ile   Thr Lys Glu Asp Lys   Thr Arg Ala 
    32135                 32140                 32145             


Met Asn   Tyr Asp Glu Glu Val   Asp Glu Thr Arg Glu   Val Ser Met 
    32150                 32155                 32160             


Thr Lys   Ala Ser His Ser Ser   Thr Lys Glu Leu Tyr   Glu Lys Tyr 
    32165                 32170                 32175             


Met Ile   Ala Glu Asp Leu Gly   Arg Gly Glu Phe Gly   Ile Val His 
    32180                 32185                 32190             


Arg Cys   Val Glu Thr Ser Ser   Lys Lys Thr Tyr Met   Ala Lys Phe 
    32195                 32200                 32205             


Val Lys   Val Lys Gly Thr Asp   Gln Val Leu Val Lys   Lys Glu Ile 
    32210                 32215                 32220             


Ser Ile   Leu Asn Ile Ala Arg   His Arg Asn Ile Leu   His Leu His 
    32225                 32230                 32235             


Glu Ser   Phe Glu Ser Met Glu   Glu Leu Val Met Ile   Phe Glu Phe 
    32240                 32245                 32250             


Ile Ser   Gly Leu Asp Ile Phe   Glu Arg Ile Asn Thr   Ser Ala Phe 
    32255                 32260                 32265             


Glu Leu   Asn Glu Arg Glu Ile   Val Ser Tyr Val His   Gln Val Cys 
    32270                 32275                 32280             


Glu Ala   Leu Gln Phe Leu His   Ser His Asn Ile Gly   His Phe Asp 
    32285                 32290                 32295             


Ile Arg   Pro Glu Asn Ile Ile   Tyr Gln Thr Arg Arg   Ser Ser Thr 
    32300                 32305                 32310             


Ile Lys   Ile Ile Glu Phe Gly   Gln Ala Arg Gln Leu   Lys Pro Gly 
    32315                 32320                 32325             


Asp Asn   Phe Arg Leu Leu Phe   Thr Ala Pro Glu Tyr   Tyr Ala Pro 
    32330                 32335                 32340             


Glu Val   His Gln His Asp Val   Val Ser Thr Ala Thr   Asp Met Trp 
    32345                 32350                 32355             


Ser Leu   Gly Thr Leu Val Tyr   Val Leu Leu Ser Gly   Ile Asn Pro 
    32360                 32365                 32370             


Phe Leu   Ala Glu Thr Asn Gln   Gln Ile Ile Glu Asn   Ile Met Asn 
    32375                 32380                 32385             


Ala Glu   Tyr Thr Phe Asp Glu   Glu Ala Phe Lys Glu   Ile Ser Ile 
    32390                 32395                 32400             


Glu Ala   Met Asp Phe Val Asp   Arg Leu Leu Val Lys   Glu Arg Lys 
    32405                 32410                 32415             


Ser Arg   Met Thr Ala Ser Glu   Ala Leu Gln His Pro   Trp Leu Lys 
    32420                 32425                 32430             


Gln Lys   Ile Glu Arg Val Ser   Thr Lys Val Ile Arg   Thr Leu Lys 
    32435                 32440                 32445             


His Arg   Arg Tyr Tyr His Thr   Leu Ile Lys Lys Asp   Leu Asn Met 
    32450                 32455                 32460             


Val Val   Ser Ala Ala Arg Ile   Ser Cys Gly Gly Ala   Ile Arg Ser 
    32465                 32470                 32475             


Gln Lys   Gly Val Ser Val Ala   Lys Val Lys Val Ala   Ser Ile Glu 
    32480                 32485                 32490             


Ile Gly   Pro Val Ser Gly Gln   Ile Met His Ala Val   Gly Glu Glu 
    32495                 32500                 32505             


Gly Gly   His Val Lys Tyr Val   Cys Lys Ile Glu Asn   Tyr Asp Gln 
    32510                 32515                 32520             


Ser Thr   Gln Val Thr Trp Tyr   Phe Gly Val Arg Gln   Leu Glu Asn 
    32525                 32530                 32535             


Ser Glu   Lys Tyr Glu Ile Thr   Tyr Glu Asp Gly Val   Ala Ile Leu 
    32540                 32545                 32550             


Tyr Val   Lys Asp Ile Thr Lys   Leu Asp Asp Gly Thr   Tyr Arg Cys 
    32555                 32560                 32565             


Lys Val   Val Asn Asp Tyr Gly   Glu Asp Ser Ser Tyr   Ala Glu Leu 
    32570                 32575                 32580             


Phe Val   Lys Gly Val Arg Glu   Val Tyr Asp Tyr Tyr   Cys Arg Arg 
    32585                 32590                 32595             


Thr Met   Lys Lys Ile Lys Arg   Arg Thr Asp Thr Met   Arg Leu Leu 
    32600                 32605                 32610             


Glu Arg   Pro Pro Glu Phe Thr   Leu Pro Leu Tyr Asn   Lys Thr Ala 
    32615                 32620                 32625             


Tyr Val   Gly Glu Asn Val Arg   Phe Gly Val Thr Ile   Thr Val His 
    32630                 32635                 32640             


Pro Glu   Pro His Val Thr Trp   Tyr Lys Ser Gly Gln   Lys Ile Lys 
    32645                 32650                 32655             


Pro Gly   Asp Asn Asp Lys Lys   Tyr Thr Phe Glu Ser   Asp Lys Gly 
    32660                 32665                 32670             


Leu Tyr   Gln Leu Thr Ile Asn   Ser Val Thr Thr Asp   Asp Asp Ala 
    32675                 32680                 32685             


Glu Tyr   Thr Val Val Ala Arg   Asn Lys Tyr Gly Glu   Asp Ser Cys 
    32690                 32695                 32700             


Lys Ala   Lys Leu Thr Val Thr   Leu His Pro Pro Pro   Thr Asp Ser 
    32705                 32710                 32715             


Thr Leu   Arg Pro Met Phe Lys   Arg Leu Leu Ala Asn   Ala Glu Cys 
    32720                 32725                 32730             


Gln Glu   Gly Gln Ser Val Cys   Phe Glu Ile Arg Val   Ser Gly Ile 
    32735                 32740                 32745             


Pro Pro   Pro Thr Leu Lys Trp   Glu Lys Asp Gly Gln   Pro Leu Ser 
    32750                 32755                 32760             


Leu Gly   Pro Asn Ile Glu Ile   Ile His Glu Gly Leu   Asp Tyr Tyr 
    32765                 32770                 32775             


Ala Leu   His Ile Arg Asp Thr   Leu Pro Glu Asp Thr   Gly Tyr Tyr 
    32780                 32785                 32790             


Arg Val   Thr Ala Thr Asn Thr   Ala Gly Ser Thr Ser   Cys Gln Ala 
    32795                 32800                 32805             


His Leu   Gln Val Glu Arg Leu   Arg Tyr Lys Lys Gln   Glu Phe Lys 
    32810                 32815                 32820             


Ser Lys   Glu Glu His Glu Arg   His Val Gln Lys Gln   Ile Asp Lys 
    32825                 32830                 32835             


Thr Leu   Arg Met Ala Glu Ile   Leu Ser Gly Thr Glu   Ser Val Pro 
    32840                 32845                 32850             


Leu Thr   Gln Val Ala Lys Glu   Ala Leu Arg Glu Ala   Ala Val Leu 
    32855                 32860                 32865             


Tyr Lys   Pro Ala Val Ser Thr   Lys Thr Val Lys Gly   Glu Phe Arg 
    32870                 32875                 32880             


Leu Glu   Ile Glu Glu Lys Lys   Glu Glu Arg Lys Leu   Arg Met Pro 
    32885                 32890                 32895             


Tyr Asp   Val Pro Glu Pro Arg   Lys Tyr Lys Gln Thr   Thr Ile Glu 
    32900                 32905                 32910             


Glu Asp   Gln Arg Ile Lys Gln   Phe Val Pro Met Ser   Asp Met Lys 
    32915                 32920                 32925             


Trp Tyr   Lys Lys Ile Arg Asp   Gln Tyr Glu Met Pro   Gly Lys Leu 
    32930                 32935                 32940             


Asp Arg   Val Val Gln Lys Arg   Pro Lys Arg Ile Arg   Leu Ser Arg 
    32945                 32950                 32955             


Trp Glu   Gln Phe Tyr Val Met   Pro Leu Pro Arg Ile   Thr Asp Gln 
    32960                 32965                 32970             


Tyr Arg   Pro Lys Trp Arg Ile   Pro Lys Leu Ser Gln   Asp Asp Leu 
    32975                 32980                 32985             


Glu Ile   Val Arg Pro Ala Arg   Arg Arg Thr Pro Ser   Pro Asp Tyr 
    32990                 32995                 33000             


Asp Phe   Tyr Tyr Arg Pro Arg   Arg Arg Ser Leu Gly   Asp Ile Ser 
    33005                 33010                 33015             


Asp Glu   Glu Leu Leu Leu Pro   Ile Asp Asp Tyr Leu   Ala Met Lys 
    33020                 33025                 33030             


Arg Thr   Glu Glu Glu Arg Leu   Arg Leu Glu Glu Glu   Leu Glu Leu 
    33035                 33040                 33045             


Gly Phe   Ser Ala Ser Pro Pro   Ser Arg Ser Pro Pro   His Phe Glu 
    33050                 33055                 33060             


Leu Ser   Ser Leu Arg Tyr Ser   Ser Pro Gln Ala His   Val Lys Val 
    33065                 33070                 33075             


Glu Glu   Thr Arg Lys Asp Phe   Arg Tyr Ser Thr Tyr   His Ile Pro 
    33080                 33085                 33090             


Thr Lys   Ala Glu Ala Ser Thr   Ser Tyr Ala Glu Leu   Arg Glu Arg 
    33095                 33100                 33105             


His Ala   Gln Ala Ala Tyr Arg   Gln Pro Lys Gln Arg   Gln Arg Ile 
    33110                 33115                 33120             


Met Ala   Glu Arg Glu Asp Glu   Glu Leu Leu Arg Pro   Val Thr Thr 
    33125                 33130                 33135             


Thr Gln   His Leu Ser Glu Tyr   Lys Ser Glu Leu Asp   Phe Met Ser 
    33140                 33145                 33150             


Lys Glu   Glu Lys Ser Arg Lys   Lys Ser Arg Arg Gln   Arg Glu Val 
    33155                 33160                 33165             


Thr Glu   Ile Thr Glu Ile Glu   Glu Glu Tyr Glu Ile   Ser Lys His 
    33170                 33175                 33180             


Ala Gln   Arg Glu Ser Ser Ser   Ser Ala Ser Arg Leu   Leu Arg Arg 
    33185                 33190                 33195             


Arg Arg   Ser Leu Ser Pro Thr   Tyr Ile Glu Leu Met   Arg Pro Val 
    33200                 33205                 33210             


Ser Glu   Leu Ile Arg Ser Arg   Pro Gln Pro Ala Glu   Glu Tyr Glu 
    33215                 33220                 33225             


Asp Asp   Thr Glu Arg Arg Ser   Pro Thr Pro Glu Arg   Thr Arg Pro 
    33230                 33235                 33240             


Arg Ser   Pro Ser Pro Val Ser   Ser Glu Arg Ser Leu   Ser Arg Phe 
    33245                 33250                 33255             


Glu Arg   Ser Ala Arg Phe Asp   Ile Phe Ser Arg Tyr   Glu Ser Met 
    33260                 33265                 33270             


Lys Ala   Ala Leu Lys Thr Gln   Lys Thr Ser Glu Arg   Lys Tyr Glu 
    33275                 33280                 33285             


Val Leu   Ser Gln Gln Pro Phe   Thr Leu Asp His Ala   Pro Arg Ile 
    33290                 33295                 33300             


Thr Leu   Arg Met Arg Ser His   Arg Val Pro Cys Gly   Gln Asn Thr 
    33305                 33310                 33315             


Arg Phe   Ile Leu Asn Val Gln   Ser Lys Pro Thr Ala   Glu Val Lys 
    33320                 33325                 33330             


Trp Tyr   His Asn Gly Val Glu   Leu Gln Glu Ser Ser   Lys Ile His 
    33335                 33340                 33345             


Tyr Thr   Asn Thr Ser Gly Val   Leu Thr Leu Glu Ile   Leu Asp Cys 
    33350                 33355                 33360             


His Thr   Asp Asp Ser Gly Thr   Tyr Arg Ala Val Cys   Thr Asn Tyr 
    33365                 33370                 33375             


Lys Gly   Glu Ala Ser Asp Tyr   Ala Thr Leu Asp Val   Thr Gly Gly 
    33380                 33385                 33390             


Asp Tyr   Thr Thr Tyr Ala Ser   Gln Arg Arg Asp Glu   Glu Val Pro 
    33395                 33400                 33405             


Arg Ser   Val Phe Pro Glu Leu   Thr Arg Thr Glu Ala   Tyr Ala Val 
    33410                 33415                 33420             


Ser Ser   Phe Lys Lys Thr Ser   Glu Met Glu Ala Ser   Ser Ser Val 
    33425                 33430                 33435             


Arg Glu   Val Lys Ser Gln Met   Thr Glu Thr Arg Glu   Ser Leu Ser 
    33440                 33445                 33450             


Ser Tyr   Glu His Ser Ala Ser   Ala Glu Met Lys Ser   Ala Ala Leu 
    33455                 33460                 33465             


Glu Glu   Lys Ser Leu Glu Glu   Lys Ser Thr Thr Arg   Lys Ile Lys 
    33470                 33475                 33480             


Thr Thr   Leu Ala Ala Arg Ile   Leu Thr Lys Pro Arg   Ser Met Thr 
    33485                 33490                 33495             


Val Tyr   Glu Gly Glu Ser Ala   Arg Phe Ser Cys Asp   Thr Asp Gly 
    33500                 33505                 33510             


Glu Pro   Val Pro Thr Val Thr   Trp Leu Arg Lys Gly   Gln Val Leu 
    33515                 33520                 33525             


Ser Thr   Ser Ala Arg His Gln   Val Thr Thr Thr Lys   Tyr Lys Ser 
    33530                 33535                 33540             


Thr Phe   Glu Ile Ser Ser Val   Gln Ala Ser Asp Glu   Gly Asn Tyr 
    33545                 33550                 33555             


Ser Val   Val Val Glu Asn Ser   Glu Gly Lys Gln Glu   Ala Glu Phe 
    33560                 33565                 33570             


Thr Leu   Thr Ile Gln Lys Ala   Arg Val Thr Glu Lys   Ala Val Thr 
    33575                 33580                 33585             


Ser Pro   Pro Arg Val Lys Ser   Pro Glu Pro Arg Val   Lys Ser Pro 
    33590                 33595                 33600             


Glu Ala   Val Lys Ser Pro Lys   Arg Val Lys Ser Pro   Glu Pro Ser 
    33605                 33610                 33615             


His Pro   Lys Ala Val Ser Pro   Thr Glu Thr Lys Pro   Thr Pro Thr 
    33620                 33625                 33630             


Glu Lys   Val Gln His Leu Pro   Val Ser Ala Pro Pro   Lys Ile Thr 
    33635                 33640                 33645             


Gln Phe   Leu Lys Ala Glu Ala   Ser Lys Glu Ile Ala   Lys Leu Thr 
    33650                 33655                 33660             


Cys Val   Val Glu Ser Ser Val   Leu Arg Ala Lys Glu   Val Thr Trp 
    33665                 33670                 33675             


Tyr Lys   Asp Gly Lys Lys Leu   Lys Glu Asn Gly His   Phe Gln Phe 
    33680                 33685                 33690             


His Tyr   Ser Ala Asp Gly Thr   Tyr Glu Leu Lys Ile   Asn Asn Leu 
    33695                 33700                 33705             


Thr Glu   Ser Asp Gln Gly Glu   Tyr Val Cys Glu Ile   Ser Gly Glu 
    33710                 33715                 33720             


Gly Gly   Thr Ser Lys Thr Asn   Leu Gln Phe Met Gly   Gln Ala Phe 
    33725                 33730                 33735             


Lys Ser   Ile His Glu Lys Val   Ser Lys Ile Ser Glu   Thr Lys Lys 
    33740                 33745                 33750             


Ser Asp   Gln Lys Thr Thr Glu   Ser Thr Val Thr Arg   Lys Thr Glu 
    33755                 33760                 33765             


Pro Lys   Ala Pro Glu Pro Ile   Ser Ser Lys Pro Val   Ile Val Thr 
    33770                 33775                 33780             


Gly Leu   Gln Asp Thr Thr Val   Ser Ser Asp Ser Val   Ala Lys Phe 
    33785                 33790                 33795             


Ala Val   Lys Ala Thr Gly Glu   Pro Arg Pro Thr Ala   Ile Trp Thr 
    33800                 33805                 33810             


Lys Asp   Gly Lys Ala Ile Thr   Gln Gly Gly Lys Tyr   Lys Leu Ser 
    33815                 33820                 33825             


Glu Asp   Lys Gly Gly Phe Phe   Leu Glu Ile His Lys   Thr Asp Thr 
    33830                 33835                 33840             


Ser Asp   Ser Gly Leu Tyr Thr   Cys Thr Val Lys Asn   Ser Ala Gly 
    33845                 33850                 33855             


Ser Val   Ser Ser Ser Cys Lys   Leu Thr Ile Lys Ala   Ile Lys Asp 
    33860                 33865                 33870             


Thr Glu   Ala Gln Lys Val Ser   Thr Gln Lys Thr Ser   Glu Ile Thr 
    33875                 33880                 33885             


Pro Gln   Lys Lys Ala Val Val   Gln Glu Glu Ile Ser   Gln Lys Ala 
    33890                 33895                 33900             


Leu Arg   Ser Glu Glu Ile Lys   Met Ser Glu Ala Lys   Ser Gln Glu 
    33905                 33910                 33915             


Lys Leu   Ala Leu Lys Glu Glu   Ala Ser Lys Val Leu   Ile Ser Glu 
    33920                 33925                 33930             


Glu Val   Lys Lys Ser Ala Ala   Thr Ser Leu Glu Lys   Ser Ile Val 
    33935                 33940                 33945             


His Glu   Glu Ile Thr Lys Thr   Ser Gln Ala Ser Glu   Glu Val Arg 
    33950                 33955                 33960             


Thr His   Ala Glu Ile Lys Ala   Phe Ser Thr Gln Met   Ser Ile Asn 
    33965                 33970                 33975             


Glu Gly   Gln Arg Leu Val Leu   Lys Ala Asn Ile Ala   Gly Ala Thr 
    33980                 33985                 33990             


Asp Val   Lys Trp Val Leu Asn   Gly Val Glu Leu Thr   Asn Ser Glu 
    33995                 34000                 34005             


Glu Tyr   Arg Tyr Gly Val Ser   Gly Ser Asp Gln Thr   Leu Thr Ile 
    34010                 34015                 34020             


Lys Gln   Ala Ser His Arg Asp   Glu Gly Ile Leu Thr   Cys Ile Ser 
    34025                 34030                 34035             


Lys Thr   Lys Glu Gly Ile Val   Lys Cys Gln Tyr Asp   Leu Thr Leu 
    34040                 34045                 34050             


Ser Lys   Glu Leu Ser Asp Ala   Pro Ala Phe Ile Ser   Gln Pro Arg 
    34055                 34060                 34065             


Ser Gln   Asn Ile Asn Glu Gly   Gln Asn Val Leu Phe   Thr Cys Glu 
    34070                 34075                 34080             


Ile Ser   Gly Glu Pro Ser Pro   Glu Ile Glu Trp Phe   Lys Asn Asn 
    34085                 34090                 34095             


Leu Pro   Ile Ser Ile Ser Ser   Asn Val Ser Ile Ser   Arg Ser Arg 
    34100                 34105                 34110             


Asn Val   Tyr Ser Leu Glu Ile   Arg Asn Ala Ser Val   Ser Asp Ser 
    34115                 34120                 34125             


Gly Lys   Tyr Thr Ile Lys Ala   Lys Asn Phe Arg Gly   Gln Cys Ser 
    34130                 34135                 34140             


Ala Thr   Ala Ser Leu Met Val   Leu Pro Leu Val Glu   Glu Pro Ser 
    34145                 34150                 34155             


Arg Glu   Val Val Leu Arg Thr   Ser Gly Asp Thr Ser   Leu Gln Gly 
    34160                 34165                 34170             


Ser Phe   Ser Ser Gln Ser Val   Gln Met Ser Ala Ser   Lys Gln Glu 
    34175                 34180                 34185             


Ala Ser   Phe Ser Ser Phe Ser   Ser Ser Ser Ala Ser   Ser Met Thr 
    34190                 34195                 34200             


Glu Met   Lys Phe Ala Ser Met   Ser Ala Gln Ser Met   Ser Ser Met 
    34205                 34210                 34215             


Gln Glu   Ser Phe Val Glu Met   Ser Ser Ser Ser Phe   Met Gly Ile 
    34220                 34225                 34230             


Ser Asn   Met Thr Gln Leu Glu   Ser Ser Thr Ser Lys   Met Leu Lys 
    34235                 34240                 34245             


Ala Gly   Ile Arg Gly Ile Pro   Pro Lys Ile Glu Ala   Leu Pro Ser 
    34250                 34255                 34260             


Asp Ile   Ser Ile Asp Glu Gly   Lys Val Leu Thr Val   Ala Cys Ala 
    34265                 34270                 34275             


Phe Thr   Gly Glu Pro Thr Pro   Glu Val Thr Trp Ser   Cys Gly Gly 
    34280                 34285                 34290             


Arg Lys   Ile His Ser Gln Glu   Gln Gly Arg Phe His   Ile Glu Asn 
    34295                 34300                 34305             


Thr Asp   Asp Leu Thr Thr Leu   Ile Ile Met Asp Val   Gln Lys Gln 
    34310                 34315                 34320             


Asp Gly   Gly Leu Tyr Thr Leu   Ser Leu Gly Asn Glu   Phe Gly Ser 
    34325                 34330                 34335             


Asp Ser   Ala Thr Val Asn Ile   His Ile Arg Ser Ile   
    34340                 34345                 34350 


<210>  106
<211>  499
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q8WWY3
<309>  2016-09-07
<313>  (1)..(499)

<400>  106

Met Ser Leu Ala Asp Glu Leu Leu Ala Asp Leu Glu Glu Ala Ala Glu 
1               5                   10                  15      


Glu Glu Glu Gly Gly Ser Tyr Gly Glu Glu Glu Glu Glu Pro Ala Ile 
            20                  25                  30          


Glu Asp Val Gln Glu Glu Thr Gln Leu Asp Leu Ser Gly Asp Ser Val 
        35                  40                  45              


Lys Thr Ile Ala Lys Leu Trp Asp Ser Lys Met Phe Ala Glu Ile Met 
    50                  55                  60                  


Met Lys Ile Glu Glu Tyr Ile Ser Lys Gln Ala Lys Ala Ser Glu Val 
65                  70                  75                  80  


Met Gly Pro Val Glu Ala Ala Pro Glu Tyr Arg Val Ile Val Asp Ala 
                85                  90                  95      


Asn Asn Leu Thr Val Glu Ile Glu Asn Glu Leu Asn Ile Ile His Lys 
            100                 105                 110         


Phe Ile Arg Asp Lys Tyr Ser Lys Arg Phe Pro Glu Leu Glu Ser Leu 
        115                 120                 125             


Val Pro Asn Ala Leu Asp Tyr Ile Arg Thr Val Lys Glu Leu Gly Asn 
    130                 135                 140                 


Ser Leu Asp Lys Cys Lys Asn Asn Glu Asn Leu Gln Gln Ile Leu Thr 
145                 150                 155                 160 


Asn Ala Thr Ile Met Val Val Ser Val Thr Ala Ser Thr Thr Gln Gly 
                165                 170                 175     


Gln Gln Leu Ser Glu Glu Glu Leu Glu Arg Leu Glu Glu Ala Cys Asp 
            180                 185                 190         


Met Ala Leu Glu Leu Asn Ala Ser Lys His Arg Ile Tyr Glu Tyr Val 
        195                 200                 205             


Glu Ser Arg Met Ser Phe Ile Ala Pro Asn Leu Ser Ile Ile Ile Gly 
    210                 215                 220                 


Ala Ser Thr Ala Ala Lys Ile Met Gly Val Ala Gly Gly Leu Thr Asn 
225                 230                 235                 240 


Leu Ser Lys Met Pro Ala Cys Asn Ile Met Leu Leu Gly Ala Gln Arg 
                245                 250                 255     


Lys Thr Leu Ser Gly Phe Ser Ser Thr Ser Val Leu Pro His Thr Gly 
            260                 265                 270         


Tyr Ile Tyr His Ser Asp Ile Val Gln Ser Leu Pro Pro Asp Leu Arg 
        275                 280                 285             


Arg Lys Ala Ala Arg Leu Val Ala Ala Lys Cys Thr Leu Ala Ala Arg 
    290                 295                 300                 


Val Asp Ser Phe His Glu Ser Thr Glu Gly Lys Val Gly Tyr Glu Leu 
305                 310                 315                 320 


Lys Asp Glu Ile Glu Arg Lys Phe Asp Lys Trp Gln Glu Pro Pro Pro 
                325                 330                 335     


Val Lys Gln Val Lys Pro Leu Pro Ala Pro Leu Asp Gly Gln Arg Lys 
            340                 345                 350         


Lys Arg Gly Gly Arg Arg Tyr Arg Lys Met Lys Glu Arg Leu Gly Leu 
        355                 360                 365             


Thr Glu Ile Arg Lys Gln Ala Asn Arg Met Ser Phe Gly Glu Ile Glu 
    370                 375                 380                 


Glu Asp Ala Tyr Gln Glu Asp Leu Gly Phe Ser Leu Gly His Leu Gly 
385                 390                 395                 400 


Lys Ser Gly Ser Gly Arg Val Arg Gln Thr Gln Val Asn Glu Ala Thr 
                405                 410                 415     


Lys Ala Arg Ile Ser Lys Thr Leu Gln Arg Thr Leu Gln Lys Gln Ser 
            420                 425                 430         


Val Val Tyr Gly Gly Lys Ser Thr Ile Arg Asp Arg Ser Ser Gly Thr 
        435                 440                 445             


Ala Ser Ser Val Ala Phe Thr Pro Leu Gln Gly Leu Glu Ile Val Asn 
    450                 455                 460                 


Pro Gln Ala Ala Glu Lys Lys Val Ala Glu Ala Asn Gln Lys Tyr Phe 
465                 470                 475                 480 


Ser Ser Met Ala Glu Phe Leu Lys Val Lys Gly Glu Lys Ser Gly Leu 
                485                 490                 495     


Met Ser Thr 
            


<210>  107
<211>  431
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P55010
<309>  2016-09-07
<313>  (1)..(431)

<400>  107

Met Ser Val Asn Val Asn Arg Ser Val Ser Asp Gln Phe Tyr Arg Tyr 
1               5                   10                  15      


Lys Met Pro Arg Leu Ile Ala Lys Val Glu Gly Lys Gly Asn Gly Ile 
            20                  25                  30          


Lys Thr Val Ile Val Asn Met Val Asp Val Ala Lys Ala Leu Asn Arg 
        35                  40                  45              


Pro Pro Thr Tyr Pro Thr Lys Tyr Phe Gly Cys Glu Leu Gly Ala Gln 
    50                  55                  60                  


Thr Gln Phe Asp Val Lys Asn Asp Arg Tyr Ile Val Asn Gly Ser His 
65                  70                  75                  80  


Glu Ala Asn Lys Leu Gln Asp Met Leu Asp Gly Phe Ile Lys Lys Phe 
                85                  90                  95      


Val Leu Cys Pro Glu Cys Glu Asn Pro Glu Thr Asp Leu His Val Asn 
            100                 105                 110         


Pro Lys Lys Gln Thr Ile Gly Asn Ser Cys Lys Ala Cys Gly Tyr Arg 
        115                 120                 125             


Gly Met Leu Asp Thr His His Lys Leu Cys Thr Phe Ile Leu Lys Asn 
    130                 135                 140                 


Pro Pro Glu Asn Ser Asp Ser Gly Thr Gly Lys Lys Glu Lys Glu Lys 
145                 150                 155                 160 


Lys Asn Arg Lys Gly Lys Asp Lys Glu Asn Gly Ser Val Ser Ser Ser 
                165                 170                 175     


Glu Thr Pro Pro Pro Pro Pro Pro Pro Asn Glu Ile Asn Pro Pro Pro 
            180                 185                 190         


His Thr Met Glu Glu Glu Glu Asp Asp Asp Trp Gly Glu Asp Thr Thr 
        195                 200                 205             


Glu Glu Ala Gln Arg Arg Arg Met Asp Glu Ile Ser Asp His Ala Lys 
    210                 215                 220                 


Val Leu Thr Leu Ser Asp Asp Leu Glu Arg Thr Ile Glu Glu Arg Val 
225                 230                 235                 240 


Asn Ile Leu Phe Asp Phe Val Lys Lys Lys Lys Glu Glu Gly Val Ile 
                245                 250                 255     


Asp Ser Ser Asp Lys Glu Ile Val Ala Glu Ala Glu Arg Leu Asp Val 
            260                 265                 270         


Lys Ala Met Gly Pro Leu Val Leu Thr Glu Val Leu Phe Asn Glu Lys 
        275                 280                 285             


Ile Arg Glu Gln Ile Lys Lys Tyr Arg Arg His Phe Leu Arg Phe Cys 
    290                 295                 300                 


His Asn Asn Lys Lys Ala Gln Arg Tyr Leu Leu His Gly Leu Glu Cys 
305                 310                 315                 320 


Val Val Ala Met His Gln Ala Gln Leu Ile Ser Lys Ile Pro His Ile 
                325                 330                 335     


Leu Lys Glu Met Tyr Asp Ala Asp Leu Leu Glu Glu Glu Val Ile Ile 
            340                 345                 350         


Ser Trp Ser Glu Lys Ala Ser Lys Lys Tyr Val Ser Lys Glu Leu Ala 
        355                 360                 365             


Lys Glu Ile Arg Val Lys Ala Glu Pro Phe Ile Lys Trp Leu Lys Glu 
    370                 375                 380                 


Ala Glu Glu Glu Ser Ser Gly Gly Glu Glu Glu Asp Glu Asp Glu Asn 
385                 390                 395                 400 


Ile Glu Val Val Tyr Ser Lys Ala Ala Ser Val Pro Lys Val Glu Thr 
                405                 410                 415     


Val Lys Ser Asp Asn Lys Asp Asp Asp Ile Asp Ile Asp Ala Ile 
            420                 425                 430     


<210>  108
<211>  375
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q99733
<309>  2016-09-07
<313>  (1)..(375)

<400>  108

Met Ala Asp His Ser Phe Ser Asp Gly Val Pro Ser Asp Ser Val Glu 
1               5                   10                  15      


Ala Ala Lys Asn Ala Ser Asn Thr Glu Lys Leu Thr Asp Gln Val Met 
            20                  25                  30          


Gln Asn Pro Arg Val Leu Ala Ala Leu Gln Glu Arg Leu Asp Asn Val 
        35                  40                  45              


Pro His Thr Pro Ser Ser Tyr Ile Glu Thr Leu Pro Lys Ala Val Lys 
    50                  55                  60                  


Arg Arg Ile Asn Ala Leu Lys Gln Leu Gln Val Arg Cys Ala His Ile 
65                  70                  75                  80  


Glu Ala Lys Phe Tyr Glu Glu Val His Asp Leu Glu Arg Lys Tyr Ala 
                85                  90                  95      


Ala Leu Tyr Gln Pro Leu Phe Asp Lys Arg Arg Glu Phe Ile Thr Gly 
            100                 105                 110         


Asp Val Glu Pro Thr Asp Ala Glu Ser Glu Trp His Ser Glu Asn Glu 
        115                 120                 125             


Glu Glu Glu Lys Leu Ala Gly Asp Met Lys Ser Lys Val Val Val Thr 
    130                 135                 140                 


Glu Lys Ala Ala Ala Thr Ala Glu Glu Pro Asp Pro Lys Gly Ile Pro 
145                 150                 155                 160 


Glu Phe Trp Phe Thr Ile Phe Arg Asn Val Asp Met Leu Ser Glu Leu 
                165                 170                 175     


Val Gln Glu Tyr Asp Glu Pro Ile Leu Lys His Leu Gln Asp Ile Lys 
            180                 185                 190         


Val Lys Phe Ser Asp Pro Gly Gln Pro Met Ser Phe Val Leu Glu Phe 
        195                 200                 205             


His Phe Glu Pro Asn Asp Tyr Phe Thr Asn Ser Val Leu Thr Lys Thr 
    210                 215                 220                 


Tyr Lys Met Lys Ser Glu Pro Asp Lys Ala Asp Pro Phe Ser Phe Glu 
225                 230                 235                 240 


Gly Pro Glu Ile Val Asp Cys Asp Gly Cys Thr Ile Asp Trp Lys Lys 
                245                 250                 255     


Gly Lys Asn Val Thr Val Lys Thr Ile Lys Lys Lys Gln Lys His Lys 
            260                 265                 270         


Gly Arg Gly Thr Val Arg Thr Ile Thr Lys Gln Val Pro Asn Glu Ser 
        275                 280                 285             


Phe Phe Asn Phe Phe Asn Pro Leu Lys Ala Ser Gly Asp Gly Glu Ser 
    290                 295                 300                 


Leu Asp Glu Asp Ser Glu Phe Thr Leu Ala Ser Asp Phe Glu Ile Gly 
305                 310                 315                 320 


His Phe Phe Arg Glu Arg Ile Val Pro Arg Ala Val Leu Tyr Phe Thr 
                325                 330                 335     


Gly Glu Ala Ile Glu Asp Asp Asp Asn Phe Glu Glu Gly Glu Glu Gly 
            340                 345                 350         


Glu Glu Glu Glu Leu Glu Gly Asp Glu Glu Gly Glu Asp Glu Asp Asp 
        355                 360                 365             


Ala Glu Ile Asn Pro Lys Val 
    370                 375 


<210>  109
<211>  308
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O14579
<309>  1999-12-30
<313>  (1)..(308)

<400>  109

Met Ala Pro Pro Ala Pro Gly Pro Ala Ser Gly Gly Ser Gly Glu Val 
1               5                   10                  15      


Asp Glu Leu Phe Asp Val Lys Asn Ala Phe Tyr Ile Gly Ser Tyr Gln 
            20                  25                  30          


Gln Cys Ile Asn Glu Ala Gln Arg Val Lys Leu Ser Ser Pro Glu Arg 
        35                  40                  45              


Asp Val Glu Arg Asp Val Phe Leu Tyr Arg Ala Tyr Leu Ala Gln Arg 
    50                  55                  60                  


Lys Phe Gly Val Val Leu Asp Glu Ile Lys Pro Ser Ser Ala Pro Glu 
65                  70                  75                  80  


Leu Gln Ala Val Arg Met Phe Ala Asp Tyr Leu Ala His Glu Ser Arg 
                85                  90                  95      


Arg Asp Ser Ile Val Ala Glu Leu Asp Arg Glu Met Ser Arg Ser Val 
            100                 105                 110         


Asp Val Thr Asn Thr Thr Phe Leu Leu Met Ala Ala Ser Ile Tyr Leu 
        115                 120                 125             


His Asp Gln Asn Pro Asp Ala Ala Leu Arg Ala Leu His Gln Gly Asp 
    130                 135                 140                 


Ser Leu Glu Cys Thr Ala Met Thr Val Gln Ile Leu Leu Lys Leu Asp 
145                 150                 155                 160 


Arg Leu Asp Leu Ala Arg Lys Glu Leu Lys Arg Met Gln Asp Leu Asp 
                165                 170                 175     


Glu Asp Ala Thr Leu Thr Gln Leu Ala Thr Ala Trp Val Ser Leu Ala 
            180                 185                 190         


Thr Gly Gly Glu Lys Leu Gln Asp Ala Tyr Tyr Ile Phe Gln Glu Met 
        195                 200                 205             


Ala Asp Lys Cys Ser Pro Thr Leu Leu Leu Leu Asn Gly Gln Ala Ala 
    210                 215                 220                 


Cys His Met Ala Gln Gly Arg Trp Glu Ala Ala Glu Gly Leu Leu Gln 
225                 230                 235                 240 


Glu Ala Leu Asp Lys Asp Ser Gly Tyr Pro Glu Thr Leu Val Asn Leu 
                245                 250                 255     


Ile Val Leu Ser Gln His Leu Gly Lys Pro Pro Glu Val Thr Asn Arg 
            260                 265                 270         


Tyr Leu Ser Gln Leu Lys Asp Ala His Arg Ser His Pro Phe Ile Lys 
        275                 280                 285             


Glu Tyr Gln Ala Lys Glu Asn Asp Phe Asp Arg Leu Val Leu Gln Tyr 
    290                 295                 300                 


Ala Pro Ser Ala 
305             


<210>  110
<211>  110
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P81605
<309>  2016-09-07
<313>  (1)..(110)

<400>  110

Met Arg Phe Met Thr Leu Leu Phe Leu Thr Ala Leu Ala Gly Ala Leu 
1               5                   10                  15      


Val Cys Ala Tyr Asp Pro Glu Ala Ala Ser Ala Pro Gly Ser Gly Asn 
            20                  25                  30          


Pro Cys His Glu Ala Ser Ala Ala Gln Lys Glu Asn Ala Gly Glu Asp 
        35                  40                  45              


Pro Gly Leu Ala Arg Gln Ala Pro Lys Pro Arg Lys Gln Arg Ser Ser 
    50                  55                  60                  


Leu Leu Glu Lys Gly Leu Asp Gly Ala Lys Lys Ala Val Gly Gly Leu 
65                  70                  75                  80  


Gly Lys Leu Gly Lys Asp Ala Val Glu Asp Leu Glu Ser Val Gly Lys 
                85                  90                  95      


Gly Ala Val His Asp Val Lys Asp Val Leu Asp Ser Val Leu 
            100                 105                 110 


<210>  111
<211>  274
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P15559
<309>  1993-04-23
<313>  (1)..(274)

<400>  111

Met Val Gly Arg Arg Ala Leu Ile Val Leu Ala His Ser Glu Arg Thr 
1               5                   10                  15      


Ser Phe Asn Tyr Ala Met Lys Glu Ala Ala Ala Ala Ala Leu Lys Lys 
            20                  25                  30          


Lys Gly Trp Glu Val Val Glu Ser Asp Leu Tyr Ala Met Asn Phe Asn 
        35                  40                  45              


Pro Ile Ile Ser Arg Lys Asp Ile Thr Gly Lys Leu Lys Asp Pro Ala 
    50                  55                  60                  


Asn Phe Gln Tyr Pro Ala Glu Ser Val Leu Ala Tyr Lys Glu Gly His 
65                  70                  75                  80  


Leu Ser Pro Asp Ile Val Ala Glu Gln Lys Lys Leu Glu Ala Ala Asp 
                85                  90                  95      


Leu Val Ile Phe Gln Phe Pro Leu Gln Trp Phe Gly Val Pro Ala Ile 
            100                 105                 110         


Leu Lys Gly Trp Phe Glu Arg Val Phe Ile Gly Glu Phe Ala Tyr Thr 
        115                 120                 125             


Tyr Ala Ala Met Tyr Asp Lys Gly Pro Phe Arg Ser Lys Lys Ala Val 
    130                 135                 140                 


Leu Ser Ile Thr Thr Gly Gly Ser Gly Ser Met Tyr Ser Leu Gln Gly 
145                 150                 155                 160 


Ile His Gly Asp Met Asn Val Ile Leu Trp Pro Ile Gln Ser Gly Ile 
                165                 170                 175     


Leu His Phe Cys Gly Phe Gln Val Leu Glu Pro Gln Leu Thr Tyr Ser 
            180                 185                 190         


Ile Gly His Thr Pro Ala Asp Ala Arg Ile Gln Ile Leu Glu Gly Trp 
        195                 200                 205             


Lys Lys Arg Leu Glu Asn Ile Trp Asp Glu Thr Pro Leu Tyr Phe Ala 
    210                 215                 220                 


Pro Ser Ser Leu Phe Asp Leu Asn Phe Gln Ala Gly Phe Leu Met Lys 
225                 230                 235                 240 


Lys Glu Val Gln Asp Glu Glu Lys Asn Lys Lys Phe Gly Leu Ser Val 
                245                 250                 255     


Gly His His Leu Gly Lys Ser Ile Pro Thr Asp Asn Gln Ile Lys Ala 
            260                 265                 270         


Arg Lys 
        


<210>  112
<211>  291
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O95983
<309>  2004-07-20
<313>  (1)..(291)

<400>  112

Met Glu Arg Lys Arg Trp Glu Cys Pro Ala Leu Pro Gln Gly Trp Glu 
1               5                   10                  15      


Arg Glu Glu Val Pro Arg Arg Ser Gly Leu Ser Ala Gly His Arg Asp 
            20                  25                  30          


Val Phe Tyr Tyr Ser Pro Ser Gly Lys Lys Phe Arg Ser Lys Pro Gln 
        35                  40                  45              


Leu Ala Arg Tyr Leu Gly Gly Ser Met Asp Leu Ser Thr Phe Asp Phe 
    50                  55                  60                  


Arg Thr Gly Lys Met Leu Met Ser Lys Met Asn Lys Ser Arg Gln Arg 
65                  70                  75                  80  


Val Arg Tyr Asp Ser Ser Asn Gln Val Lys Gly Lys Pro Asp Leu Asn 
                85                  90                  95      


Thr Ala Leu Pro Val Arg Gln Thr Ala Ser Ile Phe Lys Gln Pro Val 
            100                 105                 110         


Thr Lys Ile Thr Asn His Pro Ser Asn Lys Val Lys Ser Asp Pro Gln 
        115                 120                 125             


Lys Ala Val Asp Gln Pro Arg Gln Leu Phe Trp Glu Lys Lys Leu Ser 
    130                 135                 140                 


Gly Leu Asn Ala Phe Asp Ile Ala Glu Glu Leu Val Lys Thr Met Asp 
145                 150                 155                 160 


Leu Pro Lys Gly Leu Gln Gly Val Gly Pro Gly Cys Thr Asp Glu Thr 
                165                 170                 175     


Leu Leu Ser Ala Ile Ala Ser Ala Leu His Thr Ser Thr Met Pro Ile 
            180                 185                 190         


Thr Gly Gln Leu Ser Ala Ala Val Glu Lys Asn Pro Gly Val Trp Leu 
        195                 200                 205             


Asn Thr Thr Gln Pro Leu Cys Lys Ala Phe Met Val Thr Asp Glu Asp 
    210                 215                 220                 


Ile Arg Lys Gln Glu Glu Leu Val Gln Gln Val Arg Lys Arg Leu Glu 
225                 230                 235                 240 


Glu Ala Leu Met Ala Asp Met Leu Ala His Val Glu Glu Leu Ala Arg 
                245                 250                 255     


Asp Gly Glu Ala Pro Leu Asp Lys Ala Cys Ala Glu Asp Asp Asp Glu 
            260                 265                 270         


Glu Asp Glu Glu Glu Glu Glu Glu Glu Pro Asp Pro Asp Pro Glu Met 
        275                 280                 285             


Glu His Val 
    290     


<210>  113
<211>  1270
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q08211
<309>  2016-09-07
<313>  (1)..(1270)

<400>  113

Met Gly Asp Val Lys Asn Phe Leu Tyr Ala Trp Cys Gly Lys Arg Lys 
1               5                   10                  15      


Met Thr Pro Ser Tyr Glu Ile Arg Ala Val Gly Asn Lys Asn Arg Gln 
            20                  25                  30          


Lys Phe Met Cys Glu Val Gln Val Glu Gly Tyr Asn Tyr Thr Gly Met 
        35                  40                  45              


Gly Asn Ser Thr Asn Lys Lys Asp Ala Gln Ser Asn Ala Ala Arg Asp 
    50                  55                  60                  


Phe Val Asn Tyr Leu Val Arg Ile Asn Glu Ile Lys Ser Glu Glu Val 
65                  70                  75                  80  


Pro Ala Phe Gly Val Ala Ser Pro Pro Pro Leu Thr Asp Thr Pro Asp 
                85                  90                  95      


Thr Thr Ala Asn Ala Glu Gly Asp Leu Pro Thr Thr Met Gly Gly Pro 
            100                 105                 110         


Leu Pro Pro His Leu Ala Leu Lys Ala Glu Asn Asn Ser Glu Val Gly 
        115                 120                 125             


Ala Ser Gly Tyr Gly Val Pro Gly Pro Thr Trp Asp Arg Gly Ala Asn 
    130                 135                 140                 


Leu Lys Asp Tyr Tyr Ser Arg Lys Glu Glu Gln Glu Val Gln Ala Thr 
145                 150                 155                 160 


Leu Glu Ser Glu Glu Val Asp Leu Asn Ala Gly Leu His Gly Asn Trp 
                165                 170                 175     


Thr Leu Glu Asn Ala Lys Ala Arg Leu Asn Gln Tyr Phe Gln Lys Glu 
            180                 185                 190         


Lys Ile Gln Gly Glu Tyr Lys Tyr Thr Gln Val Gly Pro Asp His Asn 
        195                 200                 205             


Arg Ser Phe Ile Ala Glu Met Thr Ile Tyr Ile Lys Gln Leu Gly Arg 
    210                 215                 220                 


Arg Ile Phe Ala Arg Glu His Gly Ser Asn Lys Lys Leu Ala Ala Gln 
225                 230                 235                 240 


Ser Cys Ala Leu Ser Leu Val Arg Gln Leu Tyr His Leu Gly Val Val 
                245                 250                 255     


Glu Ala Tyr Ser Gly Leu Thr Lys Lys Lys Glu Gly Glu Thr Val Glu 
            260                 265                 270         


Pro Tyr Lys Val Asn Leu Ser Gln Asp Leu Glu His Gln Leu Gln Asn 
        275                 280                 285             


Ile Ile Gln Glu Leu Asn Leu Glu Ile Leu Pro Pro Pro Glu Asp Pro 
    290                 295                 300                 


Ser Val Pro Val Ala Leu Asn Ile Gly Lys Leu Ala Gln Phe Glu Pro 
305                 310                 315                 320 


Ser Gln Arg Gln Asn Gln Val Gly Val Val Pro Trp Ser Pro Pro Gln 
                325                 330                 335     


Ser Asn Trp Asn Pro Trp Thr Ser Ser Asn Ile Asp Glu Gly Pro Leu 
            340                 345                 350         


Ala Phe Ala Thr Pro Glu Gln Ile Ser Met Asp Leu Lys Asn Glu Leu 
        355                 360                 365             


Met Tyr Gln Leu Glu Gln Asp His Asp Leu Gln Ala Ile Leu Gln Glu 
    370                 375                 380                 


Arg Glu Leu Leu Pro Val Lys Lys Phe Glu Ser Glu Ile Leu Glu Ala 
385                 390                 395                 400 


Ile Ser Gln Asn Ser Val Val Ile Ile Arg Gly Ala Thr Gly Cys Gly 
                405                 410                 415     


Lys Thr Thr Gln Val Pro Gln Phe Ile Leu Asp Asp Phe Ile Gln Asn 
            420                 425                 430         


Asp Arg Ala Ala Glu Cys Asn Ile Val Val Thr Gln Pro Arg Arg Ile 
        435                 440                 445             


Ser Ala Val Ser Val Ala Glu Arg Val Ala Phe Glu Arg Gly Glu Glu 
    450                 455                 460                 


Pro Gly Lys Ser Cys Gly Tyr Ser Val Arg Phe Glu Ser Ile Leu Pro 
465                 470                 475                 480 


Arg Pro His Ala Ser Ile Met Phe Cys Thr Val Gly Val Leu Leu Arg 
                485                 490                 495     


Lys Leu Glu Ala Gly Ile Arg Gly Ile Ser His Val Ile Val Asp Glu 
            500                 505                 510         


Ile His Glu Arg Asp Ile Asn Thr Asp Phe Leu Leu Val Val Leu Arg 
        515                 520                 525             


Asp Val Val Gln Ala Tyr Pro Glu Val Arg Ile Val Leu Met Ser Ala 
    530                 535                 540                 


Thr Ile Asp Thr Ser Met Phe Cys Glu Tyr Phe Phe Asn Cys Pro Ile 
545                 550                 555                 560 


Ile Glu Val Tyr Gly Arg Thr Tyr Pro Val Gln Glu Tyr Phe Leu Glu 
                565                 570                 575     


Asp Cys Ile Gln Met Thr His Phe Val Pro Pro Pro Lys Asp Lys Lys 
            580                 585                 590         


Lys Lys Asp Lys Asp Asp Asp Gly Gly Glu Asp Asp Asp Ala Asn Cys 
        595                 600                 605             


Asn Leu Ile Cys Gly Asp Glu Tyr Gly Pro Glu Thr Arg Leu Ser Met 
    610                 615                 620                 


Ser Gln Leu Asn Glu Lys Glu Thr Pro Phe Glu Leu Ile Glu Ala Leu 
625                 630                 635                 640 


Leu Lys Tyr Ile Glu Thr Leu Asn Val Pro Gly Ala Val Leu Val Phe 
                645                 650                 655     


Leu Pro Gly Trp Asn Leu Ile Tyr Thr Met Gln Lys His Leu Glu Met 
            660                 665                 670         


Asn Pro His Phe Gly Ser His Arg Tyr Gln Ile Leu Pro Leu His Ser 
        675                 680                 685             


Gln Ile Pro Arg Glu Glu Gln Arg Lys Val Phe Asp Pro Val Pro Val 
    690                 695                 700                 


Gly Val Thr Lys Val Ile Leu Ser Thr Asn Ile Ala Glu Thr Ser Ile 
705                 710                 715                 720 


Thr Ile Asn Asp Val Val Tyr Val Ile Asp Ser Cys Lys Gln Lys Val 
                725                 730                 735     


Lys Leu Phe Thr Ala His Asn Asn Met Thr Asn Tyr Ala Thr Val Trp 
            740                 745                 750         


Ala Ser Lys Thr Asn Leu Glu Gln Arg Lys Gly Arg Ala Gly Arg Val 
        755                 760                 765             


Arg Pro Gly Phe Cys Phe His Leu Cys Ser Arg Ala Arg Phe Glu Arg 
    770                 775                 780                 


Leu Glu Thr His Met Thr Pro Glu Met Phe Arg Thr Pro Leu His Glu 
785                 790                 795                 800 


Ile Ala Leu Ser Ile Lys Leu Leu Arg Leu Gly Gly Ile Gly Gln Phe 
                805                 810                 815     


Leu Ala Lys Ala Ile Glu Pro Pro Pro Leu Asp Ala Val Ile Glu Ala 
            820                 825                 830         


Glu His Thr Leu Arg Glu Leu Asp Ala Leu Asp Ala Asn Asp Glu Leu 
        835                 840                 845             


Thr Pro Leu Gly Arg Ile Leu Ala Lys Leu Pro Ile Glu Pro Arg Phe 
    850                 855                 860                 


Gly Lys Met Met Ile Met Gly Cys Ile Phe Tyr Val Gly Asp Ala Ile 
865                 870                 875                 880 


Cys Thr Ile Ala Ala Ala Thr Cys Phe Pro Glu Pro Phe Ile Asn Glu 
                885                 890                 895     


Gly Lys Arg Leu Gly Tyr Ile His Arg Asn Phe Ala Gly Asn Arg Phe 
            900                 905                 910         


Ser Asp His Val Ala Leu Leu Ser Val Phe Gln Ala Trp Asp Asp Ala 
        915                 920                 925             


Arg Met Gly Gly Glu Glu Ala Glu Ile Arg Phe Cys Glu His Lys Arg 
    930                 935                 940                 


Leu Asn Met Ala Thr Leu Arg Met Thr Trp Glu Ala Lys Val Gln Leu 
945                 950                 955                 960 


Lys Glu Ile Leu Ile Asn Ser Gly Phe Pro Glu Asp Cys Leu Leu Thr 
                965                 970                 975     


Gln Val Phe Thr Asn Thr Gly Pro Asp Asn Asn Leu Asp Val Val Ile 
            980                 985                 990         


Ser Leu Leu Ala Phe Gly Val Tyr  Pro Asn Val Cys Tyr  His Lys Glu 
        995                 1000                 1005             


Lys Arg  Lys Ile Leu Thr Thr  Glu Gly Arg Asn Ala  Leu Ile His 
    1010                 1015                 1020             


Lys Ser  Ser Val Asn Cys Pro  Phe Ser Ser Gln Asp  Met Lys Tyr 
    1025                 1030                 1035             


Pro Ser  Pro Phe Phe Val Phe  Gly Glu Lys Ile Arg  Thr Arg Ala 
    1040                 1045                 1050             


Ile Ser  Ala Lys Gly Met Thr  Leu Val Thr Pro Leu  Gln Leu Leu 
    1055                 1060                 1065             


Leu Phe  Ala Ser Lys Lys Val  Gln Ser Asp Gly Gln  Ile Val Leu 
    1070                 1075                 1080             


Val Asp  Asp Trp Ile Lys Leu  Gln Ile Ser His Glu  Ala Ala Ala 
    1085                 1090                 1095             


Cys Ile  Thr Gly Leu Arg Ala  Ala Met Glu Ala Leu  Val Val Glu 
    1100                 1105                 1110             


Val Thr  Lys Gln Pro Ala Ile  Ile Ser Gln Leu Asp  Pro Val Asn 
    1115                 1120                 1125             


Glu Arg  Met Leu Asn Met Ile  Arg Gln Ile Ser Arg  Pro Ser Ala 
    1130                 1135                 1140             


Ala Gly  Ile Asn Leu Met Ile  Gly Ser Thr Arg Tyr  Gly Asp Gly 
    1145                 1150                 1155             


Pro Arg  Pro Pro Lys Met Ala  Arg Tyr Asp Asn Gly  Ser Gly Tyr 
    1160                 1165                 1170             


Arg Arg  Gly Gly Ser Ser Tyr  Ser Gly Gly Gly Tyr  Gly Gly Gly 
    1175                 1180                 1185             


Tyr Ser  Ser Gly Gly Tyr Gly  Ser Gly Gly Tyr Gly  Gly Ser Ala 
    1190                 1195                 1200             


Asn Ser  Phe Arg Ala Gly Tyr  Gly Ala Gly Val Gly  Gly Gly Tyr 
    1205                 1210                 1215             


Arg Gly  Val Ser Arg Gly Gly  Phe Arg Gly Asn Ser  Gly Gly Asp 
    1220                 1225                 1230             


Tyr Arg  Gly Pro Ser Gly Gly  Tyr Arg Gly Ser Gly  Gly Phe Gln 
    1235                 1240                 1245             


Arg Gly  Gly Gly Arg Gly Ala  Tyr Gly Thr Gly Tyr  Phe Gly Gln 
    1250                 1255                 1260             


Gly Arg  Gly Gly Gly Gly Tyr  
    1265                 1270 


<210>  114
<211>  341
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O95400
<309>  2003-06-03
<313>  (1)..(341)

<400>  114

Met Pro Lys Arg Lys Val Thr Phe Gln Gly Val Gly Asp Glu Glu Asp 
1               5                   10                  15      


Glu Asp Glu Ile Ile Val Pro Lys Lys Lys Leu Val Asp Pro Val Ala 
            20                  25                  30          


Gly Ser Gly Gly Pro Gly Ser Arg Phe Lys Gly Lys His Ser Leu Asp 
        35                  40                  45              


Ser Asp Glu Glu Glu Asp Asp Asp Asp Gly Gly Ser Ser Lys Tyr Asp 
    50                  55                  60                  


Ile Leu Ala Ser Glu Asp Val Glu Gly Gln Glu Ala Ala Thr Leu Pro 
65                  70                  75                  80  


Ser Glu Gly Gly Val Arg Ile Thr Pro Phe Asn Leu Gln Glu Glu Met 
                85                  90                  95      


Glu Glu Gly His Phe Asp Ala Asp Gly Asn Tyr Phe Leu Asn Arg Asp 
            100                 105                 110         


Ala Gln Ile Arg Asp Ser Trp Leu Asp Asn Ile Asp Trp Val Lys Ile 
        115                 120                 125             


Arg Glu Arg Pro Pro Gly Gln Arg Gln Ala Ser Asp Ser Glu Glu Glu 
    130                 135                 140                 


Asp Ser Leu Gly Gln Thr Ser Met Ser Ala Gln Ala Leu Leu Glu Gly 
145                 150                 155                 160 


Leu Leu Glu Leu Leu Leu Pro Arg Glu Thr Val Ala Gly Ala Leu Arg 
                165                 170                 175     


Arg Leu Gly Ala Arg Gly Gly Gly Lys Gly Arg Lys Gly Pro Gly Gln 
            180                 185                 190         


Pro Ser Ser Pro Gln Arg Leu Asp Arg Leu Ser Gly Leu Ala Asp Gln 
        195                 200                 205             


Met Val Ala Arg Gly Asn Leu Gly Val Tyr Gln Glu Thr Arg Glu Arg 
    210                 215                 220                 


Leu Ala Met Arg Leu Lys Gly Leu Gly Cys Gln Thr Leu Gly Pro His 
225                 230                 235                 240 


Asn Pro Thr Pro Pro Pro Ser Leu Asp Met Phe Ala Glu Glu Leu Ala 
                245                 250                 255     


Glu Glu Glu Leu Glu Thr Pro Thr Pro Thr Gln Arg Gly Glu Ala Glu 
            260                 265                 270         


Ser Arg Gly Asp Gly Leu Val Asp Val Met Trp Glu Tyr Lys Trp Glu 
        275                 280                 285             


Asn Thr Gly Asp Ala Glu Leu Tyr Gly Pro Phe Thr Ser Ala Gln Met 
    290                 295                 300                 


Gln Thr Trp Val Ser Glu Gly Tyr Phe Pro Asp Gly Val Tyr Cys Arg 
305                 310                 315                 320 


Lys Leu Asp Pro Pro Gly Gly Gln Phe Tyr Asn Ser Lys Arg Ile Asp 
                325                 330                 335     


Phe Asp Leu Tyr Thr 
            340     


<210>  115
<211>  142
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P69905
<309>  2016-09-07
<313>  (1)..(142)

<400>  115

Met Val Leu Ser Pro Ala Asp Lys Thr Asn Val Lys Ala Ala Trp Gly 
1               5                   10                  15      


Lys Val Gly Ala His Ala Gly Glu Tyr Gly Ala Glu Ala Leu Glu Arg 
            20                  25                  30          


Met Phe Leu Ser Phe Pro Thr Thr Lys Thr Tyr Phe Pro His Phe Asp 
        35                  40                  45              


Leu Ser His Gly Ser Ala Gln Val Lys Gly His Gly Lys Lys Val Ala 
    50                  55                  60                  


Asp Ala Leu Thr Asn Ala Val Ala His Val Asp Asp Met Pro Asn Ala 
65                  70                  75                  80  


Leu Ser Ala Leu Ser Asp Leu His Ala His Lys Leu Arg Val Asp Pro 
                85                  90                  95      


Val Asn Phe Lys Leu Leu Ser His Cys Leu Leu Val Thr Leu Ala Ala 
            100                 105                 110         


His Leu Pro Ala Glu Phe Thr Pro Ala Val His Ala Ser Leu Asp Lys 
        115                 120                 125             


Phe Leu Ala Ser Val Ser Thr Val Leu Thr Ser Lys Tyr Arg 
    130                 135                 140         


<210>  116
<211>  126
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P62318
<309>  2016-09-07
<313>  (1)..(126)

<400>  116

Met Ser Ile Gly Val Pro Ile Lys Val Leu His Glu Ala Glu Gly His 
1               5                   10                  15      


Ile Val Thr Cys Glu Thr Asn Thr Gly Glu Val Tyr Arg Gly Lys Leu 
            20                  25                  30          


Ile Glu Ala Glu Asp Asn Met Asn Cys Gln Met Ser Asn Ile Thr Val 
        35                  40                  45              


Thr Tyr Arg Asp Gly Arg Val Ala Gln Leu Glu Gln Val Tyr Ile Arg 
    50                  55                  60                  


Gly Ser Lys Ile Arg Phe Leu Ile Leu Pro Asp Met Leu Lys Asn Ala 
65                  70                  75                  80  


Pro Met Leu Lys Ser Met Lys Asn Lys Asn Gln Gly Ser Gly Ala Gly 
                85                  90                  95      


Arg Gly Lys Ala Ala Ile Leu Lys Ala Gln Val Ala Ala Arg Gly Arg 
            100                 105                 110         


Gly Arg Gly Met Gly Arg Gly Asn Ile Phe Gln Lys Arg Arg 
        115                 120                 125     


<210>  117
<211>  531
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q8N5A5
<309>  2016-09-07
<313>  (1)..(531)

<400>  117

Met Asp Glu Glu Ser Leu Glu Ser Ala Leu Gln Thr Tyr Arg Ala Gln 
1               5                   10                  15      


Leu Gln Gln Val Glu Leu Ala Leu Gly Ala Gly Leu Asp Ser Ser Glu 
            20                  25                  30          


Gln Ala Asp Leu Arg Gln Leu Gln Gly Asp Leu Lys Glu Leu Ile Glu 
        35                  40                  45              


Leu Thr Glu Ala Ser Leu Val Ser Val Arg Lys Ser Ser Leu Leu Ala 
    50                  55                  60                  


Ala Leu Asp Glu Glu Arg Pro Gly Arg Gln Glu Asp Ala Glu Tyr Gln 
65                  70                  75                  80  


Ala Phe Arg Glu Ala Ile Thr Glu Ala Val Glu Ala Pro Ala Ala Ala 
                85                  90                  95      


Arg Gly Ser Gly Ser Glu Thr Val Pro Lys Ala Glu Ala Gly Pro Glu 
            100                 105                 110         


Ser Ala Ala Gly Gly Gln Glu Glu Glu Glu Gly Glu Asp Glu Glu Glu 
        115                 120                 125             


Leu Ser Gly Thr Lys Val Ser Ala Pro Tyr Tyr Ser Ser Trp Gly Thr 
    130                 135                 140                 


Leu Glu Tyr His Asn Ala Met Val Val Gly Thr Glu Glu Ala Glu Asp 
145                 150                 155                 160 


Gly Ser Ala Gly Val Arg Val Leu Tyr Leu Tyr Pro Thr His Lys Ser 
                165                 170                 175     


Leu Lys Pro Cys Pro Phe Phe Leu Glu Gly Lys Cys Arg Phe Lys Glu 
            180                 185                 190         


Asn Cys Arg Phe Ser His Gly Gln Val Val Ser Leu Asp Glu Leu Arg 
        195                 200                 205             


Pro Phe Gln Asp Pro Asp Leu Ser Ser Leu Gln Ala Gly Ser Ala Cys 
    210                 215                 220                 


Leu Ala Lys His Gln Asp Gly Leu Trp His Ala Ala Arg Ile Thr Asp 
225                 230                 235                 240 


Val Asp Asn Gly Tyr Tyr Thr Val Lys Phe Asp Ser Leu Leu Leu Arg 
                245                 250                 255     


Glu Ala Val Val Glu Gly Asp Gly Ile Leu Pro Pro Leu Arg Thr Glu 
            260                 265                 270         


Ala Thr Glu Ser Asp Ser Asp Ser Asp Gly Thr Gly Asp Ser Ser Tyr 
        275                 280                 285             


Ala Arg Val Val Gly Ser Asp Ala Val Asp Ser Ala Gln Ser Ser Ala 
    290                 295                 300                 


Leu Cys Pro Ser Leu Ala Val Val Gly Ser Asp Ala Val Asp Ser Gly 
305                 310                 315                 320 


Thr Cys Ser Ser Ala Phe Ala Gly Trp Glu Val His Thr Arg Gly Ile 
                325                 330                 335     


Gly Ser Arg Leu Leu Thr Lys Met Gly Tyr Glu Phe Gly Lys Gly Leu 
            340                 345                 350         


Gly Arg His Ala Glu Gly Arg Val Glu Pro Ile His Ala Val Val Leu 
        355                 360                 365             


Pro Arg Gly Lys Ser Leu Asp Gln Cys Val Glu Thr Leu Gln Lys Gln 
    370                 375                 380                 


Thr Arg Val Gly Lys Ala Gly Thr Asn Lys Pro Pro Arg Cys Arg Gly 
385                 390                 395                 400 


Arg Gly Ala Arg Pro Gly Gly Arg Pro Ala Pro Arg Asn Val Phe Asp 
                405                 410                 415     


Phe Leu Asn Glu Lys Leu Gln Gly Gln Ala Pro Gly Ala Leu Glu Ala 
            420                 425                 430         


Gly Ala Ala Pro Ala Gly Arg Arg Ser Lys Asp Met Tyr His Ala Ser 
        435                 440                 445             


Lys Ser Ala Lys Arg Ala Leu Ser Leu Arg Leu Phe Gln Thr Glu Glu 
    450                 455                 460                 


Lys Ile Glu Arg Thr Gln Arg Asp Ile Arg Ser Ile Gln Glu Ala Leu 
465                 470                 475                 480 


Ala Arg Asn Ala Gly Arg His Ser Val Ala Ser Ala Gln Leu Gln Glu 
                485                 490                 495     


Lys Leu Ala Gly Ala Gln Arg Gln Leu Gly Gln Leu Arg Ala Gln Glu 
            500                 505                 510         


Ala Gly Leu Gln Gln Glu Gln Arg Lys Ala Asp Thr His Lys Lys Met 
        515                 520                 525             


Thr Glu Phe 
    530     


<210>  118
<211>  593
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q8WXI9
<309>  2016-09-07
<313>  (1)..(593)

<400>  118

Met Asp Arg Met Thr Glu Asp Ala Leu Arg Leu Asn Leu Leu Lys Arg 
1               5                   10                  15      


Ser Leu Asp Pro Ala Asp Glu Arg Asp Asp Val Leu Ala Lys Arg Leu 
            20                  25                  30          


Lys Met Glu Gly His Glu Ala Met Glu Arg Leu Lys Met Leu Ala Leu 
        35                  40                  45              


Leu Lys Arg Lys Asp Leu Ala Asn Leu Glu Val Pro His Glu Leu Pro 
    50                  55                  60                  


Thr Lys Gln Asp Gly Ser Gly Val Lys Gly Tyr Glu Glu Lys Leu Asn 
65                  70                  75                  80  


Gly Asn Leu Arg Pro His Gly Asp Asn Arg Thr Ala Gly Arg Pro Gly 
                85                  90                  95      


Lys Glu Asn Ile Asn Asp Glu Pro Val Asp Met Ser Ala Arg Arg Ser 
            100                 105                 110         


Glu Pro Glu Arg Gly Arg Leu Thr Pro Ser Pro Asp Ile Ile Val Leu 
        115                 120                 125             


Ser Asp Asn Glu Ala Ser Ser Pro Arg Ser Ser Ser Arg Met Glu Glu 
    130                 135                 140                 


Arg Leu Lys Ala Ala Asn Leu Glu Met Phe Lys Gly Lys Gly Ile Glu 
145                 150                 155                 160 


Glu Arg Gln Gln Leu Ile Lys Gln Leu Arg Asp Glu Leu Arg Leu Glu 
                165                 170                 175     


Glu Ala Arg Leu Val Leu Leu Lys Lys Leu Arg Gln Ser Gln Leu Gln 
            180                 185                 190         


Lys Glu Asn Val Val Gln Lys Thr Pro Val Val Gln Asn Ala Ala Ser 
        195                 200                 205             


Ile Val Gln Pro Ser Pro Ala His Val Gly Gln Gln Gly Leu Ser Lys 
    210                 215                 220                 


Leu Pro Ser Arg Pro Gly Ala Gln Gly Val Glu Pro Gln Asn Leu Arg 
225                 230                 235                 240 


Thr Leu Gln Gly His Ser Val Ile Arg Ser Ala Thr Asn Thr Thr Leu 
                245                 250                 255     


Pro His Met Leu Met Ser Gln Arg Val Ile Ala Pro Asn Pro Ala Gln 
            260                 265                 270         


Leu Gln Gly Gln Arg Gly Pro Pro Lys Pro Gly Leu Val Arg Thr Thr 
        275                 280                 285             


Thr Pro Asn Met Asn Pro Ala Ile Asn Tyr Gln Pro Gln Ser Ser Ser 
    290                 295                 300                 


Ser Val Pro Cys Gln Arg Thr Thr Ser Ser Ala Ile Tyr Met Asn Leu 
305                 310                 315                 320 


Ala Ser His Ile Gln Pro Gly Thr Val Asn Arg Val Ser Ser Pro Leu 
                325                 330                 335     


Pro Ser Pro Ser Ala Met Thr Asp Ala Ala Asn Ser Gln Ala Ala Ala 
            340                 345                 350         


Lys Leu Ala Leu Arg Lys Gln Leu Glu Lys Thr Leu Leu Glu Ile Pro 
        355                 360                 365             


Pro Pro Lys Pro Pro Ala Pro Leu Leu His Phe Leu Pro Ser Ala Ala 
    370                 375                 380                 


Asn Ser Glu Phe Ile Tyr Met Val Gly Leu Glu Glu Val Val Gln Ser 
385                 390                 395                 400 


Val Ile Asp Ser Gln Gly Lys Ser Cys Ala Ser Leu Leu Arg Val Glu 
                405                 410                 415     


Pro Phe Val Cys Ala Gln Cys Arg Thr Asp Phe Thr Pro His Trp Lys 
            420                 425                 430         


Gln Glu Lys Asn Gly Lys Ile Leu Cys Glu Gln Cys Met Thr Ser Asn 
        435                 440                 445             


Gln Lys Lys Ala Leu Lys Ala Glu His Thr Asn Arg Leu Lys Asn Ala 
    450                 455                 460                 


Phe Val Lys Ala Leu Gln Gln Glu Gln Glu Ile Glu Gln Arg Leu Gln 
465                 470                 475                 480 


Gln Gln Ala Ala Leu Ser Pro Thr Thr Ala Pro Ala Val Ser Ser Val 
                485                 490                 495     


Ser Lys Gln Glu Thr Ile Met Arg His His Thr Leu Arg Gln Ala Pro 
            500                 505                 510         


Gln Pro Gln Ser Ser Leu Gln Arg Gly Ile Pro Thr Ser Ala Arg Ser 
        515                 520                 525             


Met Leu Ser Asn Phe Ala Gln Ala Pro Gln Leu Ser Val Pro Gly Gly 
    530                 535                 540                 


Leu Leu Gly Met Pro Gly Val Asn Ile Ala Tyr Leu Asn Thr Gly Ile 
545                 550                 555                 560 


Gly Gly His Lys Gly Pro Ser Leu Ala Asp Arg Gln Arg Glu Tyr Leu 
                565                 570                 575     


Leu Asp Met Ile Pro Pro Arg Ser Ile Ser Gln Ser Ile Ser Gly Gln 
            580                 585                 590         


Lys 
    


<210>  119
<211>  193
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P51965
<309>  2016-09-07
<313>  (1)..(193)

<400>  119

Met Ser Asp Asp Asp Ser Arg Ala Ser Thr Ser Ser Ser Ser Ser Ser 
1               5                   10                  15      


Ser Ser Asn Gln Gln Thr Glu Lys Glu Thr Asn Thr Pro Lys Lys Lys 
            20                  25                  30          


Glu Ser Lys Val Ser Met Ser Lys Asn Ser Lys Leu Leu Ser Thr Ser 
        35                  40                  45              


Ala Lys Arg Ile Gln Lys Glu Leu Ala Asp Ile Thr Leu Asp Pro Pro 
    50                  55                  60                  


Pro Asn Cys Ser Ala Gly Pro Lys Gly Asp Asn Ile Tyr Glu Trp Arg 
65                  70                  75                  80  


Ser Thr Ile Leu Gly Pro Pro Gly Ser Val Tyr Glu Gly Gly Val Phe 
                85                  90                  95      


Phe Leu Asp Ile Thr Phe Thr Pro Glu Tyr Pro Phe Lys Pro Pro Lys 
            100                 105                 110         


Val Thr Phe Arg Thr Arg Ile Tyr His Cys Asn Ile Asn Ser Gln Gly 
        115                 120                 125             


Val Ile Cys Leu Asp Ile Leu Lys Asp Asn Trp Ser Pro Ala Leu Thr 
    130                 135                 140                 


Ile Ser Lys Val Leu Leu Ser Ile Cys Ser Leu Leu Thr Asp Cys Asn 
145                 150                 155                 160 


Pro Ala Asp Pro Leu Val Gly Ser Ile Ala Thr Gln Tyr Met Thr Asn 
                165                 170                 175     


Arg Ala Glu His Asp Arg Met Ala Arg Gln Trp Thr Lys Arg Tyr Ala 
            180                 185                 190         


Thr 
    


<210>  120
<211>  636
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q86U38
<309>  2016-09-07
<313>  (1)..(636)

<400>  120

Met Gly Gln Gly Pro Arg Ser Pro His Lys Val Gly Arg Arg Phe Pro 
1               5                   10                  15      


Ala Gly Gly Lys Arg Gly Arg Gly Ala Lys Gly Ser Gly Arg Pro Leu 
            20                  25                  30          


Pro Gly Arg Lys Arg Gln Pro Trp Pro Pro Pro Asp Gly Arg Ser Glu 
        35                  40                  45              


Pro Ala Pro Asp Ser His Pro His Leu Ser Pro Glu Ala Leu Gly Tyr 
    50                  55                  60                  


Phe Arg Arg Ala Leu Ser Ala Leu Lys Glu Ala Pro Glu Thr Gly Glu 
65                  70                  75                  80  


Glu Arg Asp Leu Met Val His Asn Ile Met Lys Glu Val Glu Thr Gln 
                85                  90                  95      


Ala Leu Ala Leu Ser Thr Asn Arg Thr Gly Ser Glu Met Leu Gln Glu 
            100                 105                 110         


Leu Leu Gly Phe Ser Pro Leu Lys Pro Leu Cys Arg Val Trp Ala Ala 
        115                 120                 125             


Leu Arg Ser Asn Leu Arg Thr Val Ala Cys His Arg Cys Gly Val His 
    130                 135                 140                 


Val Leu Gln Ser Ala Leu Leu Gln Leu Pro Arg Leu Leu Gly Ser Ala 
145                 150                 155                 160 


Ala Glu Glu Glu Glu Glu Glu Glu Glu Asp Gly Lys Asp Gly Pro Thr 
                165                 170                 175     


Glu Thr Leu Glu Glu Leu Val Leu Gly Leu Ala Ala Glu Val Cys Asp 
            180                 185                 190         


Asp Phe Leu Val Tyr Cys Gly Asp Thr His Gly Ser Phe Val Val Arg 
        195                 200                 205             


Thr Leu Leu Gln Val Leu Gly Gly Thr Ile Leu Glu Ser Glu Arg Ala 
    210                 215                 220                 


Arg Pro Arg Gly Ser Gln Ser Ser Glu Ala Gln Lys Thr Pro Ala Gln 
225                 230                 235                 240 


Glu Cys Lys Pro Ala Asp Phe Glu Val Pro Glu Thr Phe Leu Asn Arg 
                245                 250                 255     


Leu Gln Asp Leu Ser Ser Ser Phe Leu Lys Asp Ile Ala Val Phe Ile 
            260                 265                 270         


Thr Asp Lys Ile Ser Ser Phe Cys Leu Gln Val Ala Leu Gln Val Leu 
        275                 280                 285             


His Arg Lys Leu Pro Gln Phe Cys Ala His Leu Cys Asn Ala Val Ile 
    290                 295                 300                 


Gly Tyr Leu Ser Thr Arg Gly Ser Ser Val Asp Gly Ser Pro Leu Leu 
305                 310                 315                 320 


Leu Phe Leu Arg Asp Gln Thr Ser Ser Arg Leu Leu Glu Gln Val Leu 
                325                 330                 335     


Leu Val Leu Glu Pro Pro Arg Leu Gln Ser Leu Phe Glu Glu His Leu 
            340                 345                 350         


Gln Gly Gln Leu Gln Thr Leu Ala Ala His Pro Ile Ala Asn Phe Pro 
        355                 360                 365             


Leu Gln Arg Leu Leu Asp Ala Val Thr Thr Pro Glu Leu Leu Ser Pro 
    370                 375                 380                 


Val Phe Glu Glu Leu Ser Pro Val Leu Glu Ala Val Leu Ala Gln Gly 
385                 390                 395                 400 


His Pro Gly Val Val Ile Ala Leu Val Gly Ala Cys Arg Arg Val Gly 
                405                 410                 415     


Ala Tyr Gln Ala Lys Val Leu Gln Leu Leu Leu Glu Ala Phe His Cys 
            420                 425                 430         


Ala Glu Pro Ser Ser Arg Gln Val Ala Cys Val Pro Leu Phe Ala Thr 
        435                 440                 445             


Leu Met Ala Tyr Glu Val Tyr Tyr Gly Leu Thr Glu Glu Glu Gly Ala 
    450                 455                 460                 


Val Pro Ala Glu His Gln Val Ala Met Ala Ala Ala Arg Ala Leu Gly 
465                 470                 475                 480 


Asp Val Thr Val Leu Gly Ser Leu Leu Leu Gln His Leu Leu His Phe 
                485                 490                 495     


Ser Thr Pro Gly Leu Val Leu Arg Ser Leu Gly Ala Leu Thr Gly Pro 
            500                 505                 510         


Gln Leu Leu Ser Leu Ala Gln Ser Pro Ala Gly Ser His Val Leu Asp 
        515                 520                 525             


Ala Ile Leu Thr Ser Pro Ser Val Thr Arg Lys Leu Arg Arg Arg Val 
    530                 535                 540                 


Leu Gln Asn Leu Lys Gly Gln Tyr Val Ala Leu Ala Cys Ser Arg His 
545                 550                 555                 560 


Gly Ser Arg Val Leu Asp Ala Ile Trp Ser Gly Ala Ala Leu Arg Ala 
                565                 570                 575     


Arg Lys Glu Ile Ala Ala Glu Leu Gly Glu Gln Asn Gln Glu Leu Ile 
            580                 585                 590         


Arg Asp Pro Phe Gly His His Val Ala Arg Asn Val Ala Leu Thr Thr 
        595                 600                 605             


Phe Leu Lys Arg Arg Glu Ala Trp Glu Gln Gln Gln Gly Ala Val Ala 
    610                 615                 620                 


Lys Arg Arg Arg Ala Leu Asn Ser Ile Leu Glu Asp 
625                 630                 635     


<210>  121
<211>  248
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9Y3Y2
<309>  2016-09-07
<313>  (1)..(248)

<400>  121

Met Ala Ala Gln Ser Ala Pro Lys Val Val Leu Lys Ser Thr Thr Lys 
1               5                   10                  15      


Met Ser Leu Asn Glu Arg Phe Thr Asn Met Leu Lys Asn Lys Gln Pro 
            20                  25                  30          


Thr Pro Val Asn Ile Arg Ala Ser Met Gln Gln Gln Gln Gln Leu Ala 
        35                  40                  45              


Ser Ala Arg Asn Arg Arg Leu Ala Gln Gln Met Glu Asn Arg Pro Ser 
    50                  55                  60                  


Val Gln Ala Ala Leu Lys Leu Lys Gln Ser Leu Lys Gln Arg Leu Gly 
65                  70                  75                  80  


Lys Ser Asn Ile Gln Ala Arg Leu Gly Arg Pro Ile Gly Ala Leu Ala 
                85                  90                  95      


Arg Gly Ala Ile Gly Gly Arg Gly Leu Pro Ile Ile Gln Arg Gly Leu 
            100                 105                 110         


Pro Arg Gly Gly Leu Arg Gly Gly Arg Ala Thr Arg Thr Leu Leu Arg 
        115                 120                 125             


Gly Gly Met Ser Leu Arg Gly Gln Asn Leu Leu Arg Gly Gly Arg Ala 
    130                 135                 140                 


Val Ala Pro Arg Met Gly Leu Arg Arg Gly Gly Val Arg Gly Arg Gly 
145                 150                 155                 160 


Gly Pro Gly Arg Gly Gly Leu Gly Arg Gly Ala Met Gly Arg Gly Gly 
                165                 170                 175     


Ile Gly Gly Arg Gly Arg Gly Met Ile Gly Arg Gly Arg Gly Gly Phe 
            180                 185                 190         


Gly Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Ala Leu Ala Arg 
        195                 200                 205             


Pro Val Leu Thr Lys Glu Gln Leu Asp Asn Gln Leu Asp Ala Tyr Met 
    210                 215                 220                 


Ser Lys Thr Lys Gly His Leu Asp Ala Glu Leu Asp Ala Tyr Met Ala 
225                 230                 235                 240 


Gln Thr Asp Pro Glu Thr Asn Asp 
                245             


<210>  122
<211>  238
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O75940
<309>  2003-09-30
<313>  (1)..(238)

<400>  122

Met Ser Glu Asp Leu Ala Lys Gln Leu Ala Ser Tyr Lys Ala Gln Leu 
1               5                   10                  15      


Gln Gln Val Glu Ala Ala Leu Ser Gly Asn Gly Glu Asn Glu Asp Leu 
            20                  25                  30          


Leu Lys Leu Lys Lys Asp Leu Gln Glu Val Ile Glu Leu Thr Lys Asp 
        35                  40                  45              


Leu Leu Ser Thr Gln Pro Ser Glu Thr Leu Ala Ser Ser Asp Ser Phe 
    50                  55                  60                  


Ala Ser Thr Gln Pro Thr His Ser Trp Lys Val Gly Asp Lys Cys Met 
65                  70                  75                  80  


Ala Val Trp Ser Glu Asp Gly Gln Cys Tyr Glu Ala Glu Ile Glu Glu 
                85                  90                  95      


Ile Asp Glu Glu Asn Gly Thr Ala Ala Ile Thr Phe Ala Gly Tyr Gly 
            100                 105                 110         


Asn Ala Glu Val Thr Pro Leu Leu Asn Leu Lys Pro Val Glu Glu Gly 
        115                 120                 125             


Arg Lys Ala Lys Glu Asp Ser Gly Asn Lys Pro Met Ser Lys Lys Glu 
    130                 135                 140                 


Met Ile Ala Gln Gln Arg Glu Tyr Lys Lys Lys Lys Ala Leu Lys Lys 
145                 150                 155                 160 


Ala Gln Arg Ile Lys Glu Leu Glu Gln Glu Arg Glu Asp Gln Lys Val 
                165                 170                 175     


Lys Trp Gln Gln Phe Asn Asn Arg Ala Tyr Ser Lys Asn Lys Lys Gly 
            180                 185                 190         


Gln Val Lys Arg Ser Ile Phe Ala Ser Pro Glu Ser Val Thr Gly Lys 
        195                 200                 205             


Val Gly Val Gly Thr Cys Gly Ile Ala Asp Lys Pro Met Thr Gln Tyr 
    210                 215                 220                 


Gln Asp Thr Ser Lys Tyr Asn Val Arg His Leu Met Pro Gln 
225                 230                 235             


<210>  123
<211>  76
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / A8MWD9
<309>  2008-09-22
<313>  (1)..(76)

<400>  123

Met Ser Lys Ala His Pro Pro Glu Leu Lys Lys Phe Thr Asp Lys Lys 
1               5                   10                  15      


Phe Ser Leu Lys Leu Asn Gly Gly Arg His Val Gln Gly Ile Leu Arg 
            20                  25                  30          


Gly Phe Asp Pro Phe Met Asn Leu Val Ile Asp Glu Cys Val Glu Met 
        35                  40                  45              


Ala Thr Ser Gly Gln Gln Lys Asn Ile Gly Met Val Glu Ile Arg Gly 
    50                  55                  60                  


Asn Ser Ile Ile Met Leu Glu Ala Leu Glu Arg Val 
65                  70                  75      


<210>  124
<211>  76
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P62308
<309>  2016-09-07
<313>  (1)..(76)

<400>  124

Met Ser Lys Ala His Pro Pro Glu Leu Lys Lys Phe Met Asp Lys Lys 
1               5                   10                  15      


Leu Ser Leu Lys Leu Asn Gly Gly Arg His Val Gln Gly Ile Leu Arg 
            20                  25                  30          


Gly Phe Asp Pro Phe Met Asn Leu Val Ile Asp Glu Cys Val Glu Met 
        35                  40                  45              


Ala Thr Ser Gly Gln Gln Asn Asn Ile Gly Met Val Val Ile Arg Gly 
    50                  55                  60                  


Asn Ser Ile Ile Met Leu Glu Ala Leu Glu Arg Val 
65                  70                  75      


<210>  125
<211>  174
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9Y5S9
<309>  2016-09-07
<313>  (1)..(174)

<400>  125

Met Ala Asp Val Leu Asp Leu His Glu Ala Gly Gly Glu Asp Phe Ala 
1               5                   10                  15      


Met Asp Glu Asp Gly Asp Glu Ser Ile His Lys Leu Lys Glu Lys Ala 
            20                  25                  30          


Lys Lys Arg Lys Gly Arg Gly Phe Gly Ser Glu Glu Gly Ser Arg Ala 
        35                  40                  45              


Arg Met Arg Glu Asp Tyr Asp Ser Val Glu Gln Asp Gly Asp Glu Pro 
    50                  55                  60                  


Gly Pro Gln Arg Ser Val Glu Gly Trp Ile Leu Phe Val Thr Gly Val 
65                  70                  75                  80  


His Glu Glu Ala Thr Glu Glu Asp Ile His Asp Lys Phe Ala Glu Tyr 
                85                  90                  95      


Gly Glu Ile Lys Asn Ile His Leu Asn Leu Asp Arg Arg Thr Gly Tyr 
            100                 105                 110         


Leu Lys Gly Tyr Thr Leu Val Glu Tyr Glu Thr Tyr Lys Glu Ala Gln 
        115                 120                 125             


Ala Ala Met Glu Gly Leu Asn Gly Gln Asp Leu Met Gly Gln Pro Ile 
    130                 135                 140                 


Ser Val Asp Trp Cys Phe Val Arg Gly Pro Pro Lys Gly Lys Arg Arg 
145                 150                 155                 160 


Gly Gly Arg Arg Arg Ser Arg Ser Pro Asp Arg Arg Arg Arg 
                165                 170                 


<210>  126
<211>  225
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P21266
<309>  1993-04-23
<313>  (1)..(225)

<400>  126

Met Ser Cys Glu Ser Ser Met Val Leu Gly Tyr Trp Asp Ile Arg Gly 
1               5                   10                  15      


Leu Ala His Ala Ile Arg Leu Leu Leu Glu Phe Thr Asp Thr Ser Tyr 
            20                  25                  30          


Glu Glu Lys Arg Tyr Thr Cys Gly Glu Ala Pro Asp Tyr Asp Arg Ser 
        35                  40                  45              


Gln Trp Leu Asp Val Lys Phe Lys Leu Asp Leu Asp Phe Pro Asn Leu 
    50                  55                  60                  


Pro Tyr Leu Leu Asp Gly Lys Asn Lys Ile Thr Gln Ser Asn Ala Ile 
65                  70                  75                  80  


Leu Arg Tyr Ile Ala Arg Lys His Asn Met Cys Gly Glu Thr Glu Glu 
                85                  90                  95      


Glu Lys Ile Arg Val Asp Ile Ile Glu Asn Gln Val Met Asp Phe Arg 
            100                 105                 110         


Thr Gln Leu Ile Arg Leu Cys Tyr Ser Ser Asp His Glu Lys Leu Lys 
        115                 120                 125             


Pro Gln Tyr Leu Glu Glu Leu Pro Gly Gln Leu Lys Gln Phe Ser Met 
    130                 135                 140                 


Phe Leu Gly Lys Phe Ser Trp Phe Ala Gly Glu Lys Leu Thr Phe Val 
145                 150                 155                 160 


Asp Phe Leu Thr Tyr Asp Ile Leu Asp Gln Asn Arg Ile Phe Asp Pro 
                165                 170                 175     


Lys Cys Leu Asp Glu Phe Pro Asn Leu Lys Ala Phe Met Cys Arg Phe 
            180                 185                 190         


Glu Ala Leu Glu Lys Ile Ala Ala Tyr Leu Gln Ser Asp Gln Phe Cys 
        195                 200                 205             


Lys Met Pro Ile Asn Asn Lys Met Ala Gln Trp Gly Asn Lys Pro Val 
    210                 215                 220                 


Cys 
225 


<210>  127
<211>  135
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P08708
<309>  1993-04-24
<313>  (1)..(135)

<400>  127

Met Gly Arg Val Arg Thr Lys Thr Val Lys Lys Ala Ala Arg Val Ile 
1               5                   10                  15      


Ile Glu Lys Tyr Tyr Thr Arg Leu Gly Asn Asp Phe His Thr Asn Lys 
            20                  25                  30          


Arg Val Cys Glu Glu Ile Ala Ile Ile Pro Ser Lys Lys Leu Arg Asn 
        35                  40                  45              


Lys Ile Ala Gly Tyr Val Thr His Leu Met Lys Arg Ile Gln Arg Gly 
    50                  55                  60                  


Pro Val Arg Gly Ile Ser Ile Lys Leu Gln Glu Glu Glu Arg Glu Arg 
65                  70                  75                  80  


Arg Asp Asn Tyr Val Pro Glu Val Ser Ala Leu Asp Gln Glu Ile Ile 
                85                  90                  95      


Glu Val Asp Pro Asp Thr Lys Glu Met Leu Lys Leu Leu Asp Phe Gly 
            100                 105                 110         


Ser Leu Ser Asn Leu Gln Val Thr Gln Pro Thr Val Gly Met Asn Phe 
        115                 120                 125             


Lys Thr Pro Arg Gly Pro Val 
    130                 135 


<210>  128
<211>  135
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P0CW22
<309>  2015-09-16
<313>  (1)..(135)

<400>  128

Met Gly Arg Val Arg Thr Lys Thr Val Lys Lys Ala Ala Arg Val Ile 
1               5                   10                  15      


Ile Glu Lys Tyr Tyr Thr Arg Leu Gly Asn Asp Phe His Thr Asn Lys 
            20                  25                  30          


Arg Val Cys Glu Glu Ile Ala Ile Ile Pro Ser Lys Lys Leu Arg Asn 
        35                  40                  45              


Lys Ile Ala Gly Tyr Val Thr His Leu Met Lys Arg Ile Gln Arg Gly 
    50                  55                  60                  


Pro Val Arg Gly Ile Ser Ile Lys Leu Gln Glu Glu Glu Arg Glu Arg 
65                  70                  75                  80  


Arg Asp Asn Tyr Val Pro Glu Val Ser Ala Leu Asp Gln Glu Ile Ile 
                85                  90                  95      


Glu Val Asp Pro Asp Thr Lys Glu Met Leu Lys Leu Leu Asp Phe Gly 
            100                 105                 110         


Ser Leu Ser Asn Leu Gln Val Thr Gln Pro Thr Val Gly Met Asn Phe 
        115                 120                 125             


Lys Thr Pro Arg Gly Pro Val 
    130                 135 


<210>  129
<211>  856
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9BUJ2
<309>  2016-09-07
<313>  (1)..(856)

<400>  129

Met Asp Val Arg Arg Leu Lys Val Asn Glu Leu Arg Glu Glu Leu Gln 
1               5                   10                  15      


Arg Arg Gly Leu Asp Thr Arg Gly Leu Lys Ala Glu Leu Ala Glu Arg 
            20                  25                  30          


Leu Gln Ala Ala Leu Glu Ala Glu Glu Pro Asp Asp Glu Arg Glu Leu 
        35                  40                  45              


Asp Ala Asp Asp Glu Pro Gly Arg Pro Gly His Ile Asn Glu Glu Val 
    50                  55                  60                  


Glu Thr Glu Gly Gly Ser Glu Leu Glu Gly Thr Ala Gln Pro Pro Pro 
65                  70                  75                  80  


Pro Gly Leu Gln Pro His Ala Glu Pro Gly Gly Tyr Ser Gly Pro Asp 
                85                  90                  95      


Gly His Tyr Ala Met Asp Asn Ile Thr Arg Gln Asn Gln Phe Tyr Asp 
            100                 105                 110         


Thr Gln Val Ile Lys Gln Glu Asn Glu Ser Gly Tyr Glu Arg Arg Pro 
        115                 120                 125             


Leu Glu Met Glu Gln Gln Gln Ala Tyr Arg Pro Glu Met Lys Thr Glu 
    130                 135                 140                 


Met Lys Gln Gly Ala Pro Thr Ser Phe Leu Pro Pro Glu Ala Ser Gln 
145                 150                 155                 160 


Leu Lys Pro Asp Arg Gln Gln Phe Gln Ser Arg Lys Arg Pro Tyr Glu 
                165                 170                 175     


Glu Asn Arg Gly Arg Gly Tyr Phe Glu His Arg Glu Asp Arg Arg Gly 
            180                 185                 190         


Arg Ser Pro Gln Pro Pro Ala Glu Glu Asp Glu Asp Asp Phe Asp Asp 
        195                 200                 205             


Thr Leu Val Ala Ile Asp Thr Tyr Asn Cys Asp Leu His Phe Lys Val 
    210                 215                 220                 


Ala Arg Asp Arg Ser Ser Gly Tyr Pro Leu Thr Ile Glu Gly Phe Ala 
225                 230                 235                 240 


Tyr Leu Trp Ser Gly Ala Arg Ala Ser Tyr Gly Val Arg Arg Gly Arg 
                245                 250                 255     


Val Cys Phe Glu Met Lys Ile Asn Glu Glu Ile Ser Val Lys His Leu 
            260                 265                 270         


Pro Ser Thr Glu Pro Asp Pro His Val Val Arg Ile Gly Trp Ser Leu 
        275                 280                 285             


Asp Ser Cys Ser Thr Gln Leu Gly Glu Glu Pro Phe Ser Tyr Gly Tyr 
    290                 295                 300                 


Gly Gly Thr Gly Lys Lys Ser Thr Asn Ser Arg Phe Glu Asn Tyr Gly 
305                 310                 315                 320 


Asp Lys Phe Ala Glu Asn Asp Val Ile Gly Cys Phe Ala Asp Phe Glu 
                325                 330                 335     


Cys Gly Asn Asp Val Glu Leu Ser Phe Thr Lys Asn Gly Lys Trp Met 
            340                 345                 350         


Gly Ile Ala Phe Arg Ile Gln Lys Glu Ala Leu Gly Gly Gln Ala Leu 
        355                 360                 365             


Tyr Pro His Val Leu Val Lys Asn Cys Ala Val Glu Phe Asn Phe Gly 
    370                 375                 380                 


Gln Arg Ala Glu Pro Tyr Cys Ser Val Leu Pro Gly Phe Thr Phe Ile 
385                 390                 395                 400 


Gln His Leu Pro Leu Ser Glu Arg Ile Arg Gly Thr Val Gly Pro Lys 
                405                 410                 415     


Ser Lys Ala Glu Cys Glu Ile Leu Met Met Val Gly Leu Pro Ala Ala 
            420                 425                 430         


Gly Lys Thr Thr Trp Ala Ile Lys His Ala Ala Ser Asn Pro Ser Lys 
        435                 440                 445             


Lys Tyr Asn Ile Leu Gly Thr Asn Ala Ile Met Asp Lys Met Arg Val 
    450                 455                 460                 


Met Gly Leu Arg Arg Gln Arg Asn Tyr Ala Gly Arg Trp Asp Val Leu 
465                 470                 475                 480 


Ile Gln Gln Ala Thr Gln Cys Leu Asn Arg Leu Ile Gln Ile Ala Ala 
                485                 490                 495     


Arg Lys Lys Arg Asn Tyr Ile Leu Asp Gln Thr Asn Val Tyr Gly Ser 
            500                 505                 510         


Ala Gln Arg Arg Lys Met Arg Pro Phe Glu Gly Phe Gln Arg Lys Ala 
        515                 520                 525             


Ile Val Ile Cys Pro Thr Asp Glu Asp Leu Lys Asp Arg Thr Ile Lys 
    530                 535                 540                 


Arg Thr Asp Glu Glu Gly Lys Asp Val Pro Asp His Ala Val Leu Glu 
545                 550                 555                 560 


Met Lys Ala Asn Phe Thr Leu Pro Asp Val Gly Asp Phe Leu Asp Glu 
                565                 570                 575     


Val Leu Phe Ile Glu Leu Gln Arg Glu Glu Ala Asp Lys Leu Val Arg 
            580                 585                 590         


Gln Tyr Asn Glu Glu Gly Arg Lys Ala Gly Pro Pro Pro Glu Lys Arg 
        595                 600                 605             


Phe Asp Asn Arg Gly Gly Gly Gly Phe Arg Gly Arg Gly Gly Gly Gly 
    610                 615                 620                 


Gly Phe Gln Arg Tyr Glu Asn Arg Gly Pro Pro Gly Gly Asn Arg Gly 
625                 630                 635                 640 


Gly Phe Gln Asn Arg Gly Gly Gly Ser Gly Gly Gly Gly Asn Tyr Arg 
                645                 650                 655     


Gly Gly Phe Asn Arg Ser Gly Gly Gly Gly Tyr Ser Gln Asn Arg Trp 
            660                 665                 670         


Gly Asn Asn Asn Arg Asp Asn Asn Asn Ser Asn Asn Arg Gly Ser Tyr 
        675                 680                 685             


Asn Arg Ala Pro Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Pro 
    690                 695                 700                 


Gln Pro Pro Pro Gln Gln Pro Pro Pro Pro Pro Ser Tyr Ser Pro Ala 
705                 710                 715                 720 


Arg Asn Pro Pro Gly Ala Ser Thr Tyr Asn Lys Asn Ser Asn Ile Pro 
                725                 730                 735     


Gly Ser Ser Ala Asn Thr Ser Thr Pro Thr Val Ser Ser Tyr Ser Pro 
            740                 745                 750         


Pro Gln Pro Ser Tyr Ser Gln Pro Pro Tyr Asn Gln Gly Gly Tyr Ser 
        755                 760                 765             


Gln Gly Tyr Thr Ala Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Tyr 
    770                 775                 780                 


Asn Tyr Gly Ser Tyr Gly Gly Tyr Asn Pro Ala Pro Tyr Thr Pro Pro 
785                 790                 795                 800 


Pro Pro Pro Thr Ala Gln Thr Tyr Pro Gln Pro Ser Tyr Asn Gln Tyr 
                805                 810                 815     


Gln Gln Tyr Ala Gln Gln Trp Asn Gln Tyr Tyr Gln Asn Gln Gly Gln 
            820                 825                 830         


Trp Pro Pro Tyr Tyr Gly Asn Tyr Asp Tyr Gly Ser Tyr Ser Gly Asn 
        835                 840                 845             


Thr Gln Gly Gly Thr Ser Thr Gln 
    850                 855     


<210>  130
<211>  125
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P62851
<309>  2016-09-07
<313>  (1)..(125)

<400>  130

Met Pro Pro Lys Asp Asp Lys Lys Lys Lys Asp Ala Gly Lys Ser Ala 
1               5                   10                  15      


Lys Lys Asp Lys Asp Pro Val Asn Lys Ser Gly Gly Lys Ala Lys Lys 
            20                  25                  30          


Lys Lys Trp Ser Lys Gly Lys Val Arg Asp Lys Leu Asn Asn Leu Val 
        35                  40                  45              


Leu Phe Asp Lys Ala Thr Tyr Asp Lys Leu Cys Lys Glu Val Pro Asn 
    50                  55                  60                  


Tyr Lys Leu Ile Thr Pro Ala Val Val Ser Glu Arg Leu Lys Ile Arg 
65                  70                  75                  80  


Gly Ser Leu Ala Arg Ala Ala Leu Gln Glu Leu Leu Ser Lys Gly Leu 
                85                  90                  95      


Ile Lys Leu Val Ser Lys His Arg Ala Gln Val Ile Tyr Thr Arg Asn 
            100                 105                 110         


Thr Lys Gly Gly Asp Ala Pro Ala Ala Gly Glu Asp Ala 
        115                 120                 125 


<210>  131
<211>  282
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q07021
<309>  2016-09-07
<313>  (1)..(282)

<400>  131

Met Leu Pro Leu Leu Arg Cys Val Pro Arg Val Leu Gly Ser Ser Val 
1               5                   10                  15      


Ala Gly Leu Arg Ala Ala Ala Pro Ala Ser Pro Phe Arg Gln Leu Leu 
            20                  25                  30          


Gln Pro Ala Pro Arg Leu Cys Thr Arg Pro Phe Gly Leu Leu Ser Val 
        35                  40                  45              


Arg Ala Gly Ser Glu Arg Arg Pro Gly Leu Leu Arg Pro Arg Gly Pro 
    50                  55                  60                  


Cys Ala Cys Gly Cys Gly Cys Gly Ser Leu His Thr Asp Gly Asp Lys 
65                  70                  75                  80  


Ala Phe Val Asp Phe Leu Ser Asp Glu Ile Lys Glu Glu Arg Lys Ile 
                85                  90                  95      


Gln Lys His Lys Thr Leu Pro Lys Met Ser Gly Gly Trp Glu Leu Glu 
            100                 105                 110         


Leu Asn Gly Thr Glu Ala Lys Leu Val Arg Lys Val Ala Gly Glu Lys 
        115                 120                 125             


Ile Thr Val Thr Phe Asn Ile Asn Asn Ser Ile Pro Pro Thr Phe Asp 
    130                 135                 140                 


Gly Glu Glu Glu Pro Ser Gln Gly Gln Lys Val Glu Glu Gln Glu Pro 
145                 150                 155                 160 


Glu Leu Thr Ser Thr Pro Asn Phe Val Val Glu Val Ile Lys Asn Asp 
                165                 170                 175     


Asp Gly Lys Lys Ala Leu Val Leu Asp Cys His Tyr Pro Glu Asp Glu 
            180                 185                 190         


Val Gly Gln Glu Asp Glu Ala Glu Ser Asp Ile Phe Ser Ile Arg Glu 
        195                 200                 205             


Val Ser Phe Gln Ser Thr Gly Glu Ser Glu Trp Lys Asp Thr Asn Tyr 
    210                 215                 220                 


Thr Leu Asn Thr Asp Ser Leu Asp Trp Ala Leu Tyr Asp His Leu Met 
225                 230                 235                 240 


Asp Phe Leu Ala Asp Arg Gly Val Asp Asn Thr Phe Ala Asp Glu Leu 
                245                 250                 255     


Val Glu Leu Ser Thr Ala Leu Glu His Gln Glu Tyr Ile Thr Phe Leu 
            260                 265                 270         


Glu Asp Leu Lys Ser Phe Val Lys Ser Gln 
        275                 280         


<210>  132
<211>  656
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q01844
<309>  2016-09-07
<313>  (1)..(656)

<400>  132

Met Ala Ser Thr Asp Tyr Ser Thr Tyr Ser Gln Ala Ala Ala Gln Gln 
1               5                   10                  15      


Gly Tyr Ser Ala Tyr Thr Ala Gln Pro Thr Gln Gly Tyr Ala Gln Thr 
            20                  25                  30          


Thr Gln Ala Tyr Gly Gln Gln Ser Tyr Gly Thr Tyr Gly Gln Pro Thr 
        35                  40                  45              


Asp Val Ser Tyr Thr Gln Ala Gln Thr Thr Ala Thr Tyr Gly Gln Thr 
    50                  55                  60                  


Ala Tyr Ala Thr Ser Tyr Gly Gln Pro Pro Thr Gly Tyr Thr Thr Pro 
65                  70                  75                  80  


Thr Ala Pro Gln Ala Tyr Ser Gln Pro Val Gln Gly Tyr Gly Thr Gly 
                85                  90                  95      


Ala Tyr Asp Thr Thr Thr Ala Thr Val Thr Thr Thr Gln Ala Ser Tyr 
            100                 105                 110         


Ala Ala Gln Ser Ala Tyr Gly Thr Gln Pro Ala Tyr Pro Ala Tyr Gly 
        115                 120                 125             


Gln Gln Pro Ala Ala Thr Ala Pro Thr Arg Pro Gln Asp Gly Asn Lys 
    130                 135                 140                 


Pro Thr Glu Thr Ser Gln Pro Gln Ser Ser Thr Gly Gly Tyr Asn Gln 
145                 150                 155                 160 


Pro Ser Leu Gly Tyr Gly Gln Ser Asn Tyr Ser Tyr Pro Gln Val Pro 
                165                 170                 175     


Gly Ser Tyr Pro Met Gln Pro Val Thr Ala Pro Pro Ser Tyr Pro Pro 
            180                 185                 190         


Thr Ser Tyr Ser Ser Thr Gln Pro Thr Ser Tyr Asp Gln Ser Ser Tyr 
        195                 200                 205             


Ser Gln Gln Asn Thr Tyr Gly Gln Pro Ser Ser Tyr Gly Gln Gln Ser 
    210                 215                 220                 


Ser Tyr Gly Gln Gln Ser Ser Tyr Gly Gln Gln Pro Pro Thr Ser Tyr 
225                 230                 235                 240 


Pro Pro Gln Thr Gly Ser Tyr Ser Gln Ala Pro Ser Gln Tyr Ser Gln 
                245                 250                 255     


Gln Ser Ser Ser Tyr Gly Gln Gln Ser Ser Phe Arg Gln Asp His Pro 
            260                 265                 270         


Ser Ser Met Gly Val Tyr Gly Gln Glu Ser Gly Gly Phe Ser Gly Pro 
        275                 280                 285             


Gly Glu Asn Arg Ser Met Ser Gly Pro Asp Asn Arg Gly Arg Gly Arg 
    290                 295                 300                 


Gly Gly Phe Asp Arg Gly Gly Met Ser Arg Gly Gly Arg Gly Gly Gly 
305                 310                 315                 320 


Arg Gly Gly Met Gly Ser Ala Gly Glu Arg Gly Gly Phe Asn Lys Pro 
                325                 330                 335     


Gly Gly Pro Met Asp Glu Gly Pro Asp Leu Asp Leu Gly Pro Pro Val 
            340                 345                 350         


Asp Pro Asp Glu Asp Ser Asp Asn Ser Ala Ile Tyr Val Gln Gly Leu 
        355                 360                 365             


Asn Asp Ser Val Thr Leu Asp Asp Leu Ala Asp Phe Phe Lys Gln Cys 
    370                 375                 380                 


Gly Val Val Lys Met Asn Lys Arg Thr Gly Gln Pro Met Ile His Ile 
385                 390                 395                 400 


Tyr Leu Asp Lys Glu Thr Gly Lys Pro Lys Gly Asp Ala Thr Val Ser 
                405                 410                 415     


Tyr Glu Asp Pro Pro Thr Ala Lys Ala Ala Val Glu Trp Phe Asp Gly 
            420                 425                 430         


Lys Asp Phe Gln Gly Ser Lys Leu Lys Val Ser Leu Ala Arg Lys Lys 
        435                 440                 445             


Pro Pro Met Asn Ser Met Arg Gly Gly Leu Pro Pro Arg Glu Gly Arg 
    450                 455                 460                 


Gly Met Pro Pro Pro Leu Arg Gly Gly Pro Gly Gly Pro Gly Gly Pro 
465                 470                 475                 480 


Gly Gly Pro Met Gly Arg Met Gly Gly Arg Gly Gly Asp Arg Gly Gly 
                485                 490                 495     


Phe Pro Pro Arg Gly Pro Arg Gly Ser Arg Gly Asn Pro Ser Gly Gly 
            500                 505                 510         


Gly Asn Val Gln His Arg Ala Gly Asp Trp Gln Cys Pro Asn Pro Gly 
        515                 520                 525             


Cys Gly Asn Gln Asn Phe Ala Trp Arg Thr Glu Cys Asn Gln Cys Lys 
    530                 535                 540                 


Ala Pro Lys Pro Glu Gly Phe Leu Pro Pro Pro Phe Pro Pro Pro Gly 
545                 550                 555                 560 


Gly Asp Arg Gly Arg Gly Gly Pro Gly Gly Met Arg Gly Gly Arg Gly 
                565                 570                 575     


Gly Leu Met Asp Arg Gly Gly Pro Gly Gly Met Phe Arg Gly Gly Arg 
            580                 585                 590         


Gly Gly Asp Arg Gly Gly Phe Arg Gly Gly Arg Gly Met Asp Arg Gly 
        595                 600                 605             


Gly Phe Gly Gly Gly Arg Arg Gly Gly Pro Gly Gly Pro Pro Gly Pro 
    610                 615                 620                 


Leu Met Glu Gln Met Gly Gly Arg Arg Gly Gly Arg Gly Gly Pro Gly 
625                 630                 635                 640 


Lys Met Asp Lys Gly Glu His Arg Gln Glu Arg Arg Asp Arg Pro Tyr 
                645                 650                 655     


<210>  133
<211>  118
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P62316
<309>  2016-09-07
<313>  (1)..(118)

<400>  133

Met Ser Leu Leu Asn Lys Pro Lys Ser Glu Met Thr Pro Glu Glu Leu 
1               5                   10                  15      


Gln Lys Arg Glu Glu Glu Glu Phe Asn Thr Gly Pro Leu Ser Val Leu 
            20                  25                  30          


Thr Gln Ser Val Lys Asn Asn Thr Gln Val Leu Ile Asn Cys Arg Asn 
        35                  40                  45              


Asn Lys Lys Leu Leu Gly Arg Val Lys Ala Phe Asp Arg His Cys Asn 
    50                  55                  60                  


Met Val Leu Glu Asn Val Lys Glu Met Trp Thr Glu Val Pro Lys Ser 
65                  70                  75                  80  


Gly Lys Gly Lys Lys Lys Ser Lys Pro Val Asn Lys Asp Arg Tyr Ile 
                85                  90                  95      


Ser Lys Met Phe Leu Arg Gly Asp Ser Val Ile Val Val Leu Arg Asn 
            100                 105                 110         


Pro Leu Ile Ala Gly Lys 
        115             


<210>  134
<211>  106
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P0CG04
<309>  2010-06-15
<313>  (1)..(106)

<400>  134

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  135
<211>  106
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P0CG05
<309>  2010-06-15
<313>  (1)..(106)

<400>  135

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  136
<211>  106
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P0CG06
<309>  2010-06-15
<313>  (1)..(106)

<400>  136

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Ala Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  137
<211>  106
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P0CF74
<309>  2010-04-20
<313>  (1)..(106)

<400>  137

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Asn Thr Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  138
<211>  106
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / A0M8Q6
<309>  2010-04-20
<313>  (1)..(106)

<400>  138

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  139
<211>  214
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / B9A064
<309>  2011-03-08
<313>  (1)..(214)

<400>  139

Met Arg Pro Lys Thr Gly Gln Val Gly Cys Glu Thr Pro Glu Glu Leu 
1               5                   10                  15      


Gly Pro Gly Pro Arg Gln Arg Trp Pro Leu Leu Leu Leu Gly Leu Ala 
            20                  25                  30          


Met Val Ala His Gly Leu Leu Arg Pro Met Val Ala Pro Gln Ser Gly 
        35                  40                  45              


Asp Pro Asp Pro Gly Ala Ser Val Gly Ser Ser Arg Ser Ser Leu Arg 
    50                  55                  60                  


Ser Leu Trp Gly Arg Leu Leu Leu Gln Pro Ser Pro Gln Arg Ala Asp 
65                  70                  75                  80  


Pro Arg Cys Trp Pro Arg Gly Phe Trp Ser Glu Pro Gln Ser Leu Cys 
                85                  90                  95      


Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  140
<211>  425
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q09028
<309>  2016-09-07
<313>  (1)..(425)

<400>  140

Met Ala Asp Lys Glu Ala Ala Phe Asp Asp Ala Val Glu Glu Arg Val 
1               5                   10                  15      


Ile Asn Glu Glu Tyr Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr 
            20                  25                  30          


Asp Leu Val Met Thr His Ala Leu Glu Trp Pro Ser Leu Thr Ala Gln 
        35                  40                  45              


Trp Leu Pro Asp Val Thr Arg Pro Glu Gly Lys Asp Phe Ser Ile His 
    50                  55                  60                  


Arg Leu Val Leu Gly Thr His Thr Ser Asp Glu Gln Asn His Leu Val 
65                  70                  75                  80  


Ile Ala Ser Val Gln Leu Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser 
                85                  90                  95      


His Tyr Asp Ser Glu Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Ser 
            100                 105                 110         


Gly Lys Ile Glu Ile Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn 
        115                 120                 125             


Arg Ala Arg Tyr Met Pro Gln Asn Pro Cys Ile Ile Ala Thr Lys Thr 
    130                 135                 140                 


Pro Ser Ser Asp Val Leu Val Phe Asp Tyr Thr Lys His Pro Ser Lys 
145                 150                 155                 160 


Pro Asp Pro Ser Gly Glu Cys Asn Pro Asp Leu Arg Leu Arg Gly His 
                165                 170                 175     


Gln Lys Glu Gly Tyr Gly Leu Ser Trp Asn Pro Asn Leu Ser Gly His 
            180                 185                 190         


Leu Leu Ser Ala Ser Asp Asp His Thr Ile Cys Leu Trp Asp Ile Ser 
        195                 200                 205             


Ala Val Pro Lys Glu Gly Lys Val Val Asp Ala Lys Thr Ile Phe Thr 
    210                 215                 220                 


Gly His Thr Ala Val Val Glu Asp Val Ser Trp His Leu Leu His Glu 
225                 230                 235                 240 


Ser Leu Phe Gly Ser Val Ala Asp Asp Gln Lys Leu Met Ile Trp Asp 
                245                 250                 255     


Thr Arg Ser Asn Asn Thr Ser Lys Pro Ser His Ser Val Asp Ala His 
            260                 265                 270         


Thr Ala Glu Val Asn Cys Leu Ser Phe Asn Pro Tyr Ser Glu Phe Ile 
        275                 280                 285             


Leu Ala Thr Gly Ser Ala Asp Lys Thr Val Ala Leu Trp Asp Leu Arg 
    290                 295                 300                 


Asn Leu Lys Leu Lys Leu His Ser Phe Glu Ser His Lys Asp Glu Ile 
305                 310                 315                 320 


Phe Gln Val Gln Trp Ser Pro His Asn Glu Thr Ile Leu Ala Ser Ser 
                325                 330                 335     


Gly Thr Asp Arg Arg Leu Asn Val Trp Asp Leu Ser Lys Ile Gly Glu 
            340                 345                 350         


Glu Gln Ser Pro Glu Asp Ala Glu Asp Gly Pro Pro Glu Leu Leu Phe 
        355                 360                 365             


Ile His Gly Gly His Thr Ala Lys Ile Ser Asp Phe Ser Trp Asn Pro 
    370                 375                 380                 


Asn Glu Pro Trp Val Ile Cys Ser Val Ser Glu Asp Asn Ile Met Gln 
385                 390                 395                 400 


Val Trp Gln Met Ala Glu Asn Ile Tyr Asn Asp Glu Asp Pro Glu Gly 
                405                 410                 415     


Ser Val Asp Pro Glu Gly Gln Gly Ser 
            420                 425 


<210>  141
<211>  106
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P01834
<309>  1993-04-23
<313>  (1)..(106)

<400>  141

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  142
<211>  1074
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q96KR1
<309>  2016-09-07
<313>  (1)..(1074)

<400>  142

Met Ile Pro Ile Cys Pro Val Val Ser Phe Thr Tyr Val Pro Ser Arg 
1               5                   10                  15      


Leu Gly Glu Asp Ala Lys Met Ala Thr Gly Asn Tyr Phe Gly Phe Thr 
            20                  25                  30          


His Ser Gly Ala Ala Ala Ala Ala Ala Ala Ala Gln Tyr Ser Gln Gln 
        35                  40                  45              


Pro Ala Ser Gly Val Ala Tyr Ser His Pro Thr Thr Val Ala Ser Tyr 
    50                  55                  60                  


Thr Val His Gln Ala Pro Val Ala Ala His Thr Val Thr Ala Ala Tyr 
65                  70                  75                  80  


Ala Pro Ala Ala Ala Thr Val Ala Val Ala Arg Pro Ala Pro Val Ala 
                85                  90                  95      


Val Ala Ala Ala Ala Thr Ala Ala Ala Tyr Gly Gly Tyr Pro Thr Ala 
            100                 105                 110         


His Thr Ala Thr Asp Tyr Gly Tyr Thr Gln Arg Gln Gln Glu Ala Pro 
        115                 120                 125             


Pro Pro Pro Pro Pro Ala Thr Thr Gln Asn Tyr Gln Asp Ser Tyr Ser 
    130                 135                 140                 


Tyr Val Arg Ser Thr Ala Pro Ala Val Ala Tyr Asp Ser Lys Gln Tyr 
145                 150                 155                 160 


Tyr Gln Gln Pro Thr Ala Thr Ala Ala Ala Val Ala Ala Ala Ala Gln 
                165                 170                 175     


Pro Gln Pro Ser Val Ala Glu Thr Tyr Tyr Gln Thr Ala Pro Lys Ala 
            180                 185                 190         


Gly Tyr Ser Gln Gly Ala Thr Gln Tyr Thr Gln Ala Gln Gln Thr Arg 
        195                 200                 205             


Gln Val Thr Ala Ile Lys Pro Ala Thr Pro Ser Pro Ala Thr Thr Thr 
    210                 215                 220                 


Phe Ser Ile Tyr Pro Val Ser Ser Thr Val Gln Pro Val Ala Ala Ala 
225                 230                 235                 240 


Ala Thr Val Val Pro Ser Tyr Thr Gln Ser Ala Thr Tyr Ser Thr Thr 
                245                 250                 255     


Ala Val Thr Tyr Ser Gly Thr Ser Tyr Ser Gly Tyr Glu Ala Ala Val 
            260                 265                 270         


Tyr Ser Ala Ala Ser Ser Tyr Tyr Gln Gln Gln Gln Gln Gln Gln Lys 
        275                 280                 285             


Gln Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Ala Ala Trp Thr 
    290                 295                 300                 


Gly Thr Thr Phe Thr Lys Lys Ala Pro Phe Gln Asn Lys Gln Leu Lys 
305                 310                 315                 320 


Pro Lys Gln Pro Pro Lys Pro Pro Gln Ile His Tyr Cys Asp Val Cys 
                325                 330                 335     


Lys Ile Ser Cys Ala Gly Pro Gln Thr Tyr Lys Glu His Leu Glu Gly 
            340                 345                 350         


Gln Lys His Lys Lys Lys Glu Ala Ala Leu Lys Ala Ser Gln Asn Thr 
        355                 360                 365             


Ser Ser Ser Asn Ser Ser Thr Arg Gly Thr Gln Asn Gln Leu Arg Cys 
    370                 375                 380                 


Glu Leu Cys Asp Val Ser Cys Thr Gly Ala Asp Ala Tyr Ala Ala His 
385                 390                 395                 400 


Ile Arg Gly Ala Lys His Gln Lys Val Val Lys Leu His Thr Lys Leu 
                405                 410                 415     


Gly Lys Pro Ile Pro Ser Thr Glu Pro Asn Val Val Ser Gln Ala Thr 
            420                 425                 430         


Ser Ser Thr Ala Val Ser Ala Ser Lys Pro Thr Ala Ser Pro Ser Ser 
        435                 440                 445             


Ile Ala Ala Asn Asn Cys Thr Val Asn Thr Ser Ser Val Ala Thr Ser 
    450                 455                 460                 


Ser Met Lys Gly Leu Thr Thr Thr Gly Asn Ser Ser Leu Asn Ser Thr 
465                 470                 475                 480 


Ser Asn Thr Lys Val Ser Ala Val Pro Thr Asn Met Ala Ala Lys Lys 
                485                 490                 495     


Thr Ser Thr Pro Lys Ile Asn Phe Val Gly Gly Asn Lys Leu Gln Ser 
            500                 505                 510         


Thr Gly Asn Lys Ala Glu Asp Ile Lys Gly Thr Glu Cys Val Lys Ser 
        515                 520                 525             


Thr Pro Val Thr Ser Ala Val Gln Ile Pro Glu Val Lys Gln Asp Thr 
    530                 535                 540                 


Val Ser Glu Pro Val Thr Pro Ala Ser Leu Ala Ala Leu Gln Ser Asp 
545                 550                 555                 560 


Val Gln Pro Val Gly His Asp Tyr Val Glu Glu Val Arg Asn Asp Glu 
                565                 570                 575     


Gly Lys Val Ile Arg Phe His Cys Lys Leu Cys Glu Cys Ser Phe Asn 
            580                 585                 590         


Asp Pro Asn Ala Lys Glu Met His Leu Lys Gly Arg Arg His Arg Leu 
        595                 600                 605             


Gln Tyr Lys Lys Lys Val Asn Pro Asp Leu Gln Val Glu Val Lys Pro 
    610                 615                 620                 


Ser Ile Arg Ala Arg Lys Ile Gln Glu Glu Lys Met Arg Lys Gln Met 
625                 630                 635                 640 


Gln Lys Glu Glu Tyr Trp Arg Arg Arg Glu Glu Glu Glu Arg Trp Arg 
                645                 650                 655     


Met Glu Met Arg Arg Tyr Glu Glu Asp Met Tyr Trp Arg Arg Met Glu 
            660                 665                 670         


Glu Glu Gln His His Trp Asp Asp Arg Arg Arg Met Pro Asp Gly Gly 
        675                 680                 685             


Tyr Pro His Gly Pro Pro Gly Pro Leu Gly Leu Leu Gly Val Arg Pro 
    690                 695                 700                 


Gly Met Pro Pro Gln Pro Gln Gly Pro Ala Pro Leu Arg Arg Pro Asp 
705                 710                 715                 720 


Ser Ser Asp Asp Arg Tyr Val Met Thr Lys His Ala Thr Ile Tyr Pro 
                725                 730                 735     


Thr Glu Glu Glu Leu Gln Ala Val Gln Lys Ile Val Ser Ile Thr Glu 
            740                 745                 750         


Arg Ala Leu Lys Leu Val Ser Asp Ser Leu Ser Glu His Glu Lys Asn 
        755                 760                 765             


Lys Asn Lys Glu Gly Asp Asp Lys Lys Glu Gly Gly Lys Asp Arg Ala 
    770                 775                 780                 


Leu Lys Gly Val Leu Arg Val Gly Val Leu Ala Lys Gly Leu Leu Leu 
785                 790                 795                 800 


Arg Gly Asp Arg Asn Val Asn Leu Val Leu Leu Cys Ser Glu Lys Pro 
                805                 810                 815     


Ser Lys Thr Leu Leu Ser Arg Ile Ala Glu Asn Leu Pro Lys Gln Leu 
            820                 825                 830         


Ala Val Ile Ser Pro Glu Lys Tyr Asp Ile Lys Cys Ala Val Ser Glu 
        835                 840                 845             


Ala Ala Ile Ile Leu Asn Ser Cys Val Glu Pro Lys Met Gln Val Thr 
    850                 855                 860                 


Ile Thr Leu Thr Ser Pro Ile Ile Arg Glu Glu Asn Met Arg Glu Gly 
865                 870                 875                 880 


Asp Val Thr Ser Gly Met Val Lys Asp Pro Pro Asp Val Leu Asp Arg 
                885                 890                 895     


Gln Lys Cys Leu Asp Ala Leu Ala Ala Leu Arg His Ala Lys Trp Phe 
            900                 905                 910         


Gln Ala Arg Ala Asn Gly Leu Gln Ser Cys Val Ile Ile Ile Arg Ile 
        915                 920                 925             


Leu Arg Asp Leu Cys Gln Arg Val Pro Thr Trp Ser Asp Phe Pro Ser 
    930                 935                 940                 


Trp Ala Met Glu Leu Leu Val Glu Lys Ala Ile Ser Ser Ala Ser Ser 
945                 950                 955                 960 


Pro Gln Ser Pro Gly Asp Ala Leu Arg Arg Val Phe Glu Cys Ile Ser 
                965                 970                 975     


Ser Gly Ile Ile Leu Lys Gly Ser Pro Gly Leu Leu Asp Pro Cys Glu 
            980                 985                 990         


Lys Asp Pro Phe Asp Thr Leu Ala  Thr Met Thr Asp Gln  Gln Arg Glu 
        995                 1000                 1005             


Asp Ile  Thr Ser Ser Ala Gln  Phe Ala Leu Arg Leu  Leu Ala Phe 
    1010                 1015                 1020             


Arg Gln  Ile His Lys Val Leu  Gly Met Asp Pro Leu  Pro Gln Met 
    1025                 1030                 1035             


Ser Gln  Arg Phe Asn Ile His  Asn Asn Arg Lys Arg  Arg Arg Asp 
    1040                 1045                 1050             


Ser Asp  Gly Val Asp Gly Phe  Glu Ala Glu Gly Lys  Lys Asp Lys 
    1055                 1060                 1065             


Lys Asp  Tyr Asp Asn Phe 
    1070                 


<210>  143
<211>  248
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q07955
<309>  2016-09-07
<313>  (1)..(248)

<400>  143

Met Ser Gly Gly Gly Val Ile Arg Gly Pro Ala Gly Asn Asn Asp Cys 
1               5                   10                  15      


Arg Ile Tyr Val Gly Asn Leu Pro Pro Asp Ile Arg Thr Lys Asp Ile 
            20                  25                  30          


Glu Asp Val Phe Tyr Lys Tyr Gly Ala Ile Arg Asp Ile Asp Leu Lys 
        35                  40                  45              


Asn Arg Arg Gly Gly Pro Pro Phe Ala Phe Val Glu Phe Glu Asp Pro 
    50                  55                  60                  


Arg Asp Ala Glu Asp Ala Val Tyr Gly Arg Asp Gly Tyr Asp Tyr Asp 
65                  70                  75                  80  


Gly Tyr Arg Leu Arg Val Glu Phe Pro Arg Ser Gly Arg Gly Thr Gly 
                85                  90                  95      


Arg Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Pro Arg Gly Arg Tyr 
            100                 105                 110         


Gly Pro Pro Ser Arg Arg Ser Glu Asn Arg Val Val Val Ser Gly Leu 
        115                 120                 125             


Pro Pro Ser Gly Ser Trp Gln Asp Leu Lys Asp His Met Arg Glu Ala 
    130                 135                 140                 


Gly Asp Val Cys Tyr Ala Asp Val Tyr Arg Asp Gly Thr Gly Val Val 
145                 150                 155                 160 


Glu Phe Val Arg Lys Glu Asp Met Thr Tyr Ala Val Arg Lys Leu Asp 
                165                 170                 175     


Asn Thr Lys Phe Arg Ser His Glu Gly Glu Thr Ala Tyr Ile Arg Val 
            180                 185                 190         


Lys Val Asp Gly Pro Arg Ser Pro Ser Tyr Gly Arg Ser Arg Ser Arg 
        195                 200                 205             


Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Asn Ser Arg Ser Arg 
    210                 215                 220                 


Ser Tyr Ser Pro Arg Arg Ser Arg Gly Ser Pro Arg Tyr Ser Pro Arg 
225                 230                 235                 240 


His Ser Arg Ser Arg Ser Arg Thr 
                245             


<210>  144
<211>  114
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P05386
<309>  1993-04-24
<313>  (1)..(114)

<400>  144

Met Ala Ser Val Ser Glu Leu Ala Cys Ile Tyr Ser Ala Leu Ile Leu 
1               5                   10                  15      


His Asp Asp Glu Val Thr Val Thr Glu Asp Lys Ile Asn Ala Leu Ile 
            20                  25                  30          


Lys Ala Ala Gly Val Asn Val Glu Pro Phe Trp Pro Gly Leu Phe Ala 
        35                  40                  45              


Lys Ala Leu Ala Asn Val Asn Ile Gly Ser Leu Ile Cys Asn Val Gly 
    50                  55                  60                  


Ala Gly Gly Pro Ala Pro Ala Ala Gly Ala Ala Pro Ala Gly Gly Pro 
65                  70                  75                  80  


Ala Pro Ser Thr Ala Ala Ala Pro Ala Glu Glu Lys Lys Val Glu Ala 
                85                  90                  95      


Lys Lys Glu Glu Ser Glu Glu Ser Asp Asp Asp Met Gly Phe Gly Leu 
            100                 105                 110         


Phe Asp 
        


<210>  145
<211>  185
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P51452
<309>  2016-09-07
<313>  (1)..(185)

<400>  145

Met Ser Gly Ser Phe Glu Leu Ser Val Gln Asp Leu Asn Asp Leu Leu 
1               5                   10                  15      


Ser Asp Gly Ser Gly Cys Tyr Ser Leu Pro Ser Gln Pro Cys Asn Glu 
            20                  25                  30          


Val Thr Pro Arg Ile Tyr Val Gly Asn Ala Ser Val Ala Gln Asp Ile 
        35                  40                  45              


Pro Lys Leu Gln Lys Leu Gly Ile Thr His Val Leu Asn Ala Ala Glu 
    50                  55                  60                  


Gly Arg Ser Phe Met His Val Asn Thr Asn Ala Asn Phe Tyr Lys Asp 
65                  70                  75                  80  


Ser Gly Ile Thr Tyr Leu Gly Ile Lys Ala Asn Asp Thr Gln Glu Phe 
                85                  90                  95      


Asn Leu Ser Ala Tyr Phe Glu Arg Ala Ala Asp Phe Ile Asp Gln Ala 
            100                 105                 110         


Leu Ala Gln Lys Asn Gly Arg Val Leu Val His Cys Arg Glu Gly Tyr 
        115                 120                 125             


Ser Arg Ser Pro Thr Leu Val Ile Ala Tyr Leu Met Met Arg Gln Lys 
    130                 135                 140                 


Met Asp Val Lys Ser Ala Leu Ser Ile Val Arg Gln Asn Arg Glu Ile 
145                 150                 155                 160 


Gly Pro Asn Asp Gly Phe Leu Ala Gln Leu Cys Gln Leu Asn Asp Arg 
                165                 170                 175     


Leu Ala Lys Glu Gly Lys Leu Lys Pro 
            180                 185 


<210>  146
<211>  281
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P29692
<309>  1993-05-06
<313>  (1)..(281)

<400>  146

Met Ala Thr Asn Phe Leu Ala His Glu Lys Ile Trp Phe Asp Lys Phe 
1               5                   10                  15      


Lys Tyr Asp Asp Ala Glu Arg Arg Phe Tyr Glu Gln Met Asn Gly Pro 
            20                  25                  30          


Val Ala Gly Ala Ser Arg Gln Glu Asn Gly Ala Ser Val Ile Leu Arg 
        35                  40                  45              


Asp Ile Ala Arg Ala Arg Glu Asn Ile Gln Lys Ser Leu Ala Gly Ser 
    50                  55                  60                  


Ser Gly Pro Gly Ala Ser Ser Gly Thr Ser Gly Asp His Gly Glu Leu 
65                  70                  75                  80  


Val Val Arg Ile Ala Ser Leu Glu Val Glu Asn Gln Ser Leu Arg Gly 
                85                  90                  95      


Val Val Gln Glu Leu Gln Gln Ala Ile Ser Lys Leu Glu Ala Arg Leu 
            100                 105                 110         


Asn Val Leu Glu Lys Ser Ser Pro Gly His Arg Ala Thr Ala Pro Gln 
        115                 120                 125             


Thr Gln His Val Ser Pro Met Arg Gln Val Glu Pro Pro Ala Lys Lys 
    130                 135                 140                 


Pro Ala Thr Pro Ala Glu Asp Asp Glu Asp Asp Asp Ile Asp Leu Phe 
145                 150                 155                 160 


Gly Ser Asp Asn Glu Glu Glu Asp Lys Glu Ala Ala Gln Leu Arg Glu 
                165                 170                 175     


Glu Arg Leu Arg Gln Tyr Ala Glu Lys Lys Ala Lys Lys Pro Ala Leu 
            180                 185                 190         


Val Ala Lys Ser Ser Ile Leu Leu Asp Val Lys Pro Trp Asp Asp Glu 
        195                 200                 205             


Thr Asp Met Ala Gln Leu Glu Ala Cys Val Arg Ser Ile Gln Leu Asp 
    210                 215                 220                 


Gly Leu Val Trp Gly Ala Ser Lys Leu Val Pro Val Gly Tyr Gly Ile 
225                 230                 235                 240 


Arg Lys Leu Gln Ile Gln Cys Val Val Glu Asp Asp Lys Val Gly Thr 
                245                 250                 255     


Asp Leu Leu Glu Glu Glu Ile Thr Lys Phe Glu Glu His Val Gln Ser 
            260                 265                 270         


Val Asp Ile Ala Ala Phe Asn Lys Ile 
        275                 280     


<210>  147
<211>  125
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P62899
<309>  2016-09-07
<313>  (1)..(125)

<400>  147

Met Ala Pro Ala Lys Lys Gly Gly Glu Lys Lys Lys Gly Arg Ser Ala 
1               5                   10                  15      


Ile Asn Glu Val Val Thr Arg Glu Tyr Thr Ile Asn Ile His Lys Arg 
            20                  25                  30          


Ile His Gly Val Gly Phe Lys Lys Arg Ala Pro Arg Ala Leu Lys Glu 
        35                  40                  45              


Ile Arg Lys Phe Ala Met Lys Glu Met Gly Thr Pro Asp Val Arg Ile 
    50                  55                  60                  


Asp Thr Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Asn Val 
65                  70                  75                  80  


Pro Tyr Arg Ile Arg Val Arg Leu Ser Arg Lys Arg Asn Glu Asp Glu 
                85                  90                  95      


Asp Ser Pro Asn Lys Leu Tyr Thr Leu Val Thr Tyr Val Pro Val Thr 
            100                 105                 110         


Thr Phe Lys Asn Leu Gln Thr Val Asn Val Asp Glu Asn 
        115                 120                 125 


<210>  148
<211>  357
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / A6NHT5
<309>  2008-06-14
<313>  (1)..(357)

<400>  148

Met Pro Glu Pro Gly Pro Asp Ala Ala Gly Thr Ala Ser Ala Gln Pro 
1               5                   10                  15      


Gln Pro Pro Pro Pro Pro Pro Pro Ala Pro Lys Glu Ser Pro Phe Ser 
            20                  25                  30          


Ile Lys Asn Leu Leu Asn Gly Asp His His Arg Pro Pro Pro Lys Pro 
        35                  40                  45              


Gln Pro Pro Pro Arg Thr Leu Phe Ala Pro Ala Ser Ala Ala Ala Ala 
    50                  55                  60                  


Ala Ala Ala Ala Ala Ala Ala Ala Ala Lys Gly Ala Leu Glu Gly Ala 
65                  70                  75                  80  


Ala Gly Phe Ala Leu Ser Gln Val Gly Asp Leu Ala Phe Pro Arg Phe 
                85                  90                  95      


Glu Ile Pro Ala Gln Arg Phe Ala Leu Pro Ala His Tyr Leu Glu Arg 
            100                 105                 110         


Ser Pro Ala Trp Trp Tyr Pro Tyr Thr Leu Thr Pro Ala Gly Gly His 
        115                 120                 125             


Leu Pro Arg Pro Glu Ala Ser Glu Lys Ala Leu Leu Arg Asp Ser Ser 
    130                 135                 140                 


Pro Ala Ser Gly Thr Asp Arg Asp Ser Pro Glu Pro Leu Leu Lys Ala 
145                 150                 155                 160 


Asp Pro Asp His Lys Glu Leu Asp Ser Lys Ser Pro Asp Glu Ile Ile 
                165                 170                 175     


Leu Glu Glu Ser Asp Ser Glu Glu Ser Lys Lys Glu Gly Glu Ala Ala 
            180                 185                 190         


Pro Gly Ala Ala Gly Ala Ser Val Gly Ala Ala Ala Ala Thr Pro Gly 
        195                 200                 205             


Ala Glu Asp Trp Lys Lys Gly Ala Glu Ser Pro Glu Lys Lys Pro Ala 
    210                 215                 220                 


Cys Arg Lys Lys Lys Thr Arg Thr Val Phe Ser Arg Ser Gln Val Phe 
225                 230                 235                 240 


Gln Leu Glu Ser Thr Phe Asp Met Lys Arg Tyr Leu Ser Ser Ser Glu 
                245                 250                 255     


Arg Ala Gly Leu Ala Ala Ser Leu His Leu Thr Glu Thr Gln Val Lys 
            260                 265                 270         


Ile Trp Phe Gln Asn Arg Arg Asn Lys Trp Lys Arg Gln Leu Ala Ala 
        275                 280                 285             


Glu Leu Glu Ala Ala Asn Leu Ser His Ala Ala Ala Gln Arg Ile Val 
    290                 295                 300                 


Arg Val Pro Ile Leu Tyr His Glu Asn Ser Ala Ala Glu Gly Ala Ala 
305                 310                 315                 320 


Ala Ala Ala Ala Gly Ala Pro Val Pro Val Ser Gln Pro Leu Leu Thr 
                325                 330                 335     


Phe Pro His Pro Val Tyr Tyr Ser His Pro Val Val Ser Ser Val Pro 
            340                 345                 350         


Leu Leu Arg Pro Val 
        355         


<210>  149
<211>  178
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P62913
<309>  2016-09-07
<313>  (1)..(178)

<400>  149

Met Ala Gln Asp Gln Gly Glu Lys Glu Asn Pro Met Arg Glu Leu Arg 
1               5                   10                  15      


Ile Arg Lys Leu Cys Leu Asn Ile Cys Val Gly Glu Ser Gly Asp Arg 
            20                  25                  30          


Leu Thr Arg Ala Ala Lys Val Leu Glu Gln Leu Thr Gly Gln Thr Pro 
        35                  40                  45              


Val Phe Ser Lys Ala Arg Tyr Thr Val Arg Ser Phe Gly Ile Arg Arg 
    50                  55                  60                  


Asn Glu Lys Ile Ala Val His Cys Thr Val Arg Gly Ala Lys Ala Glu 
65                  70                  75                  80  


Glu Ile Leu Glu Lys Gly Leu Lys Val Arg Glu Tyr Glu Leu Arg Lys 
                85                  90                  95      


Asn Asn Phe Ser Asp Thr Gly Asn Phe Gly Phe Gly Ile Gln Glu His 
            100                 105                 110         


Ile Asp Leu Gly Ile Lys Tyr Asp Pro Ser Ile Gly Ile Tyr Gly Leu 
        115                 120                 125             


Asp Phe Tyr Val Val Leu Gly Arg Pro Gly Phe Ser Ile Ala Asp Lys 
    130                 135                 140                 


Lys Arg Arg Thr Gly Cys Ile Gly Ala Lys His Arg Ile Ser Lys Glu 
145                 150                 155                 160 


Glu Ala Met Arg Trp Phe Gln Gln Lys Tyr Asp Gly Ile Ile Leu Pro 
                165                 170                 175     


Gly Lys 
        


<210>  150
<211>  793
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q15459
<309>  2016-09-07
<313>  (1)..(793)

<400>  150

Met Pro Ala Gly Pro Val Gln Ala Val Pro Pro Pro Pro Pro Val Pro 
1               5                   10                  15      


Thr Glu Pro Lys Gln Pro Thr Glu Glu Glu Ala Ser Ser Lys Glu Asp 
            20                  25                  30          


Ser Ala Pro Ser Lys Pro Val Val Gly Ile Ile Tyr Pro Pro Pro Glu 
        35                  40                  45              


Val Arg Asn Ile Val Asp Lys Thr Ala Ser Phe Val Ala Arg Asn Gly 
    50                  55                  60                  


Pro Glu Phe Glu Ala Arg Ile Arg Gln Asn Glu Ile Asn Asn Pro Lys 
65                  70                  75                  80  


Phe Asn Phe Leu Asn Pro Asn Asp Pro Tyr His Ala Tyr Tyr Arg His 
                85                  90                  95      


Lys Val Ser Glu Phe Lys Glu Gly Lys Ala Gln Glu Pro Ser Ala Ala 
            100                 105                 110         


Ile Pro Lys Val Met Gln Gln Gln Gln Gln Thr Thr Gln Gln Gln Leu 
        115                 120                 125             


Pro Gln Lys Val Gln Ala Gln Val Ile Gln Glu Thr Ile Val Pro Lys 
    130                 135                 140                 


Glu Pro Pro Pro Glu Phe Glu Phe Ile Ala Asp Pro Pro Ser Ile Ser 
145                 150                 155                 160 


Ala Phe Asp Leu Asp Val Val Lys Leu Thr Ala Gln Phe Val Ala Arg 
                165                 170                 175     


Asn Gly Arg Gln Phe Leu Thr Gln Leu Met Gln Lys Glu Gln Arg Asn 
            180                 185                 190         


Tyr Gln Phe Asp Phe Leu Arg Pro Gln His Ser Leu Phe Asn Tyr Phe 
        195                 200                 205             


Thr Lys Leu Val Glu Gln Tyr Thr Lys Ile Leu Ile Pro Pro Lys Gly 
    210                 215                 220                 


Leu Phe Ser Lys Leu Lys Lys Glu Ala Glu Asn Pro Arg Glu Val Leu 
225                 230                 235                 240 


Asp Gln Val Cys Tyr Arg Val Glu Trp Ala Lys Phe Gln Glu Arg Glu 
                245                 250                 255     


Arg Lys Lys Glu Glu Glu Glu Lys Glu Lys Glu Arg Val Ala Tyr Ala 
            260                 265                 270         


Gln Ile Asp Trp His Asp Phe Val Val Val Glu Thr Val Asp Phe Gln 
        275                 280                 285             


Pro Asn Glu Gln Gly Asn Phe Pro Pro Pro Thr Thr Pro Glu Glu Leu 
    290                 295                 300                 


Gly Ala Arg Ile Leu Ile Gln Glu Arg Tyr Glu Lys Phe Gly Glu Ser 
305                 310                 315                 320 


Glu Glu Val Glu Met Glu Val Glu Ser Asp Glu Glu Asp Asp Lys Gln 
                325                 330                 335     


Glu Lys Ala Glu Glu Pro Pro Ser Gln Leu Asp Gln Asp Thr Gln Val 
            340                 345                 350         


Gln Asp Met Asp Glu Gly Ser Asp Asp Glu Glu Glu Gly Gln Lys Val 
        355                 360                 365             


Pro Pro Pro Pro Glu Thr Pro Met Pro Pro Pro Leu Pro Pro Thr Pro 
    370                 375                 380                 


Asp Gln Val Ile Val Arg Lys Asp Tyr Asp Pro Lys Ala Ser Lys Pro 
385                 390                 395                 400 


Leu Pro Pro Ala Pro Ala Pro Asp Glu Tyr Leu Val Ser Pro Ile Thr 
                405                 410                 415     


Gly Glu Lys Ile Pro Ala Ser Lys Met Gln Glu His Met Arg Ile Gly 
            420                 425                 430         


Leu Leu Asp Pro Arg Trp Leu Glu Gln Arg Asp Arg Ser Ile Arg Glu 
        435                 440                 445             


Lys Gln Ser Asp Asp Glu Val Tyr Ala Pro Gly Leu Asp Ile Glu Ser 
    450                 455                 460                 


Ser Leu Lys Gln Leu Ala Glu Arg Arg Thr Asp Ile Phe Gly Val Glu 
465                 470                 475                 480 


Glu Thr Ala Ile Gly Lys Lys Ile Gly Glu Glu Glu Ile Gln Lys Pro 
                485                 490                 495     


Glu Glu Lys Val Thr Trp Asp Gly His Ser Gly Ser Met Ala Arg Thr 
            500                 505                 510         


Gln Gln Ala Ala Gln Ala Asn Ile Thr Leu Gln Glu Gln Ile Glu Ala 
        515                 520                 525             


Ile His Lys Ala Lys Gly Leu Val Pro Glu Asp Asp Thr Lys Glu Lys 
    530                 535                 540                 


Ile Gly Pro Ser Lys Pro Asn Glu Ile Pro Gln Gln Pro Pro Pro Pro 
545                 550                 555                 560 


Ser Ser Ala Thr Asn Ile Pro Ser Ser Ala Pro Pro Ile Thr Ser Val 
                565                 570                 575     


Pro Arg Pro Pro Thr Met Pro Pro Pro Val Arg Thr Thr Val Val Ser 
            580                 585                 590         


Ala Val Pro Val Met Pro Arg Pro Pro Met Ala Ser Val Val Arg Leu 
        595                 600                 605             


Pro Pro Gly Ser Val Ile Ala Pro Met Pro Pro Ile Ile His Ala Pro 
    610                 615                 620                 


Arg Ile Asn Val Val Pro Met Pro Pro Ser Ala Pro Pro Ile Met Ala 
625                 630                 635                 640 


Pro Arg Pro Pro Pro Met Ile Val Pro Thr Ala Phe Val Pro Ala Pro 
                645                 650                 655     


Pro Val Ala Pro Val Pro Ala Pro Ala Pro Met Pro Pro Val His Pro 
            660                 665                 670         


Pro Pro Pro Met Glu Asp Glu Pro Thr Ser Lys Lys Leu Lys Thr Glu 
        675                 680                 685             


Asp Ser Leu Met Pro Glu Glu Glu Phe Leu Arg Arg Asn Lys Gly Pro 
    690                 695                 700                 


Val Ser Ile Lys Val Gln Val Pro Asn Met Gln Asp Lys Thr Glu Trp 
705                 710                 715                 720 


Lys Leu Asn Gly Gln Val Leu Val Phe Thr Leu Pro Leu Thr Asp Gln 
                725                 730                 735     


Val Ser Val Ile Lys Val Lys Ile His Glu Ala Thr Gly Met Pro Ala 
            740                 745                 750         


Gly Lys Gln Lys Leu Gln Tyr Glu Gly Ile Phe Ile Lys Asp Ser Asn 
        755                 760                 765             


Ser Leu Ala Tyr Tyr Asn Met Ala Asn Gly Ala Val Ile His Leu Ala 
    770                 775                 780                 


Leu Lys Glu Arg Gly Gly Arg Lys Lys 
785                 790             


<210>  151
<211>  357
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q96DI7
<309>  2016-09-07
<313>  (1)..(357)

<400>  151

Met Ile Glu Gln Gln Lys Arg Lys Gly Pro Glu Leu Pro Leu Val Pro 
1               5                   10                  15      


Val Lys Arg Gln Arg His Glu Leu Leu Leu Gly Ala Gly Ser Gly Pro 
            20                  25                  30          


Gly Ala Gly Gln Gln Gln Ala Thr Pro Gly Ala Leu Leu Gln Ala Gly 
        35                  40                  45              


Pro Pro Arg Cys Ser Ser Leu Gln Ala Pro Ile Met Leu Leu Ser Gly 
    50                  55                  60                  


His Glu Gly Glu Val Tyr Cys Cys Lys Phe His Pro Asn Gly Ser Thr 
65                  70                  75                  80  


Leu Ala Ser Ala Gly Phe Asp Arg Leu Ile Leu Leu Trp Asn Val Tyr 
                85                  90                  95      


Gly Asp Cys Asp Asn Tyr Ala Thr Leu Lys Gly His Ser Gly Ala Val 
            100                 105                 110         


Met Glu Leu His Tyr Asn Thr Asp Gly Ser Met Leu Phe Ser Ala Ser 
        115                 120                 125             


Thr Asp Lys Thr Val Ala Val Trp Asp Ser Glu Thr Gly Glu Arg Val 
    130                 135                 140                 


Lys Arg Leu Lys Gly His Thr Ser Phe Val Asn Ser Cys Tyr Pro Ala 
145                 150                 155                 160 


Arg Arg Gly Pro Gln Leu Val Cys Thr Gly Ser Asp Asp Gly Thr Val 
                165                 170                 175     


Lys Leu Trp Asp Ile Arg Lys Lys Ala Ala Ile Gln Thr Phe Gln Asn 
            180                 185                 190         


Thr Tyr Gln Val Leu Ala Val Thr Phe Asn Asp Thr Ser Asp Gln Ile 
        195                 200                 205             


Ile Ser Gly Gly Ile Asp Asn Asp Ile Lys Val Trp Asp Leu Arg Gln 
    210                 215                 220                 


Asn Lys Leu Thr Tyr Thr Met Arg Gly His Ala Asp Ser Val Thr Gly 
225                 230                 235                 240 


Leu Ser Leu Ser Ser Glu Gly Ser Tyr Leu Leu Ser Asn Ala Met Asp 
                245                 250                 255     


Asn Thr Val Arg Val Trp Asp Val Arg Pro Phe Ala Pro Lys Glu Arg 
            260                 265                 270         


Cys Val Lys Ile Phe Gln Gly Asn Val His Asn Phe Glu Lys Asn Leu 
        275                 280                 285             


Leu Arg Cys Ser Trp Ser Pro Asp Gly Ser Lys Ile Ala Ala Gly Ser 
    290                 295                 300                 


Ala Asp Arg Phe Val Tyr Val Trp Asp Thr Thr Ser Arg Arg Ile Leu 
305                 310                 315                 320 


Tyr Lys Leu Pro Gly His Ala Gly Ser Ile Asn Glu Val Ala Phe His 
                325                 330                 335     


Pro Asp Glu Pro Ile Ile Ile Ser Ala Ser Ser Asp Lys Arg Leu Tyr 
            340                 345                 350         


Met Gly Glu Ile Gln 
        355         


<210>  152
<211>  727
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9H6T0
<309>  2016-09-07
<313>  (1)..(727)

<400>  152

Met Thr Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Asp Pro Ala 
1               5                   10                  15      


Ala Asp Pro Ala Ala Asp Pro Cys Pro Trp Pro Gly Ser Leu Val Val 
            20                  25                  30          


Leu Phe Gly Ala Thr Ala Gly Ala Leu Gly Arg Asp Leu Gly Ser Asp 
        35                  40                  45              


Glu Thr Asp Leu Ile Leu Leu Val Trp Gln Val Val Glu Pro Arg Ser 
    50                  55                  60                  


Arg Gln Val Gly Thr Leu His Lys Ser Leu Val Arg Ala Glu Ala Ala 
65                  70                  75                  80  


Ala Leu Ser Thr Gln Cys Arg Glu Ala Ser Gly Leu Ser Ala Asp Ser 
                85                  90                  95      


Leu Ala Arg Ala Glu Pro Leu Asp Lys Val Leu Gln Gln Phe Ser Gln 
            100                 105                 110         


Leu Val Asn Gly Asp Val Ala Leu Leu Gly Gly Gly Pro Tyr Met Leu 
        115                 120                 125             


Cys Thr Asp Gly Gln Gln Leu Leu Arg Gln Val Leu His Pro Glu Ala 
    130                 135                 140                 


Ser Arg Lys Asn Leu Val Leu Pro Asp Met Phe Phe Ser Phe Tyr Asp 
145                 150                 155                 160 


Leu Arg Arg Glu Phe His Met Gln His Pro Ser Thr Cys Pro Ala Arg 
                165                 170                 175     


Asp Leu Thr Val Ala Thr Met Ala Gln Gly Leu Gly Leu Glu Thr Asp 
            180                 185                 190         


Ala Thr Glu Asp Asp Phe Gly Val Trp Glu Val Lys Thr Met Val Ala 
        195                 200                 205             


Val Ile Leu His Leu Leu Lys Glu Pro Ser Ser Gln Leu Phe Ser Lys 
    210                 215                 220                 


Pro Glu Val Ile Lys Gln Lys Tyr Glu Thr Gly Pro Cys Ser Asp Ser 
225                 230                 235                 240 


Thr Val Pro Cys Pro Tyr Ser Ser Lys Ala Asp Val Val Asp Ser Glu 
                245                 250                 255     


Thr Val Val Arg Ala Arg Gly Leu Pro Trp Gln Ser Ser Asp Gln Asp 
            260                 265                 270         


Val Ala Arg Phe Phe Lys Gly Leu Asn Val Ala Arg Gly Gly Val Ala 
        275                 280                 285             


Leu Cys Leu Asn Ala Gln Gly Arg Arg Asn Gly Glu Ala Leu Ile Arg 
    290                 295                 300                 


Phe Val Asp Ser Glu Gln Arg Asp Leu Ala Leu Gln Arg His Lys His 
305                 310                 315                 320 


His Met Gly Val Arg Tyr Ile Glu Val Tyr Lys Ala Thr Gly Glu Glu 
                325                 330                 335     


Phe Val Lys Ile Ala Gly Gly Thr Ser Leu Glu Val Ala Arg Phe Leu 
            340                 345                 350         


Ser Arg Glu Asp Gln Val Ile Leu Arg Leu Arg Gly Leu Pro Phe Ser 
        355                 360                 365             


Ala Gly Pro Thr Asp Val Leu Gly Phe Leu Gly Pro Glu Cys Pro Val 
    370                 375                 380                 


Thr Gly Gly Thr Glu Gly Leu Leu Phe Val Arg His Pro Asp Gly Arg 
385                 390                 395                 400 


Pro Thr Gly Asp Ala Phe Ala Leu Phe Ala Cys Glu Glu Leu Ala Gln 
                405                 410                 415     


Ala Ala Leu Arg Arg His Lys Gly Met Leu Gly Lys Arg Tyr Ile Glu 
            420                 425                 430         


Leu Phe Arg Ser Thr Ala Ala Glu Val Gln Gln Val Leu Asn Arg Tyr 
        435                 440                 445             


Ala Ser Gly Pro Leu Leu Pro Thr Leu Thr Ala Pro Leu Leu Pro Ile 
    450                 455                 460                 


Pro Phe Pro Leu Ala Pro Gly Thr Gly Arg Asp Cys Val Arg Leu Arg 
465                 470                 475                 480 


Gly Leu Pro Tyr Thr Ala Thr Ile Glu Asp Ile Leu Ser Phe Leu Gly 
                485                 490                 495     


Glu Ala Ala Ala Asp Ile Arg Pro His Gly Val His Met Val Leu Asn 
            500                 505                 510         


Gln Gln Gly Arg Pro Ser Gly Asp Ala Phe Ile Gln Met Thr Ser Ala 
        515                 520                 525             


Glu Arg Ala Leu Ala Ala Ala Gln Arg Cys His Lys Lys Val Met Lys 
    530                 535                 540                 


Glu Arg Tyr Val Glu Val Val Pro Cys Ser Thr Glu Glu Met Ser Arg 
545                 550                 555                 560 


Val Leu Met Gly Gly Thr Leu Gly Arg Ser Gly Met Ser Pro Pro Pro 
                565                 570                 575     


Cys Lys Leu Pro Cys Leu Ser Pro Pro Thr Tyr Thr Thr Phe Gln Ala 
            580                 585                 590         


Thr Pro Thr Leu Ile Pro Thr Glu Thr Ala Ala Leu Tyr Pro Ser Ser 
        595                 600                 605             


Ala Leu Leu Pro Ala Ala Arg Val Pro Ala Ala Pro Thr Pro Val Ala 
    610                 615                 620                 


Tyr Tyr Pro Gly Pro Ala Thr Gln Leu Tyr Leu Asn Tyr Thr Ala Tyr 
625                 630                 635                 640 


Tyr Pro Ser Pro Pro Val Ser Pro Thr Thr Val Gly Tyr Leu Thr Thr 
                645                 650                 655     


Pro Thr Ala Ala Leu Ala Ser Ala Pro Thr Ser Val Leu Ser Gln Ser 
            660                 665                 670         


Gly Ala Leu Val Arg Met Gln Gly Val Pro Tyr Thr Ala Gly Met Lys 
        675                 680                 685             


Asp Leu Leu Ser Val Phe Gln Ala Tyr Gln Leu Pro Ala Asp Asp Tyr 
    690                 695                 700                 


Thr Ser Leu Met Pro Val Gly Asp Pro Pro Arg Thr Val Leu Gln Ala 
705                 710                 715                 720 


Pro Lys Glu Trp Val Cys Leu 
                725         


<210>  153
<211>  243
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P23396
<309>  1993-04-24
<313>  (1)..(243)

<400>  153

Met Ala Val Gln Ile Ser Lys Lys Arg Lys Phe Val Ala Asp Gly Ile 
1               5                   10                  15      


Phe Lys Ala Glu Leu Asn Glu Phe Leu Thr Arg Glu Leu Ala Glu Asp 
            20                  25                  30          


Gly Tyr Ser Gly Val Glu Val Arg Val Thr Pro Thr Arg Thr Glu Ile 
        35                  40                  45              


Ile Ile Leu Ala Thr Arg Thr Gln Asn Val Leu Gly Glu Lys Gly Arg 
    50                  55                  60                  


Arg Ile Arg Glu Leu Thr Ala Val Val Gln Lys Arg Phe Gly Phe Pro 
65                  70                  75                  80  


Glu Gly Ser Val Glu Leu Tyr Ala Glu Lys Val Ala Thr Arg Gly Leu 
                85                  90                  95      


Cys Ala Ile Ala Gln Ala Glu Ser Leu Arg Tyr Lys Leu Leu Gly Gly 
            100                 105                 110         


Leu Ala Val Arg Arg Ala Cys Tyr Gly Val Leu Arg Phe Ile Met Glu 
        115                 120                 125             


Ser Gly Ala Lys Gly Cys Glu Val Val Val Ser Gly Lys Leu Arg Gly 
    130                 135                 140                 


Gln Arg Ala Lys Ser Met Lys Phe Val Asp Gly Leu Met Ile His Ser 
145                 150                 155                 160 


Gly Asp Pro Val Asn Tyr Tyr Val Asp Thr Ala Val Arg His Val Leu 
                165                 170                 175     


Leu Arg Gln Gly Val Leu Gly Ile Lys Val Lys Ile Met Leu Pro Trp 
            180                 185                 190         


Asp Pro Thr Gly Lys Ile Gly Pro Lys Lys Pro Leu Pro Asp His Val 
        195                 200                 205             


Ser Ile Val Glu Pro Lys Asp Glu Ile Leu Pro Thr Thr Pro Ile Ser 
    210                 215                 220                 


Glu Gln Lys Gly Gly Lys Pro Glu Pro Pro Ala Met Pro Gln Pro Val 
225                 230                 235                 240 


Pro Thr Ala 
            


<210>  154
<211>  1127
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9UPN9
<309>  2016-09-07
<313>  (1)..(1127)

<400>  154

Met Ala Glu Asn Lys Gly Gly Gly Glu Ala Glu Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Ser Ala Pro Val Thr Ala Gly Ala Ala Gly Pro Ala Ala Gln 
            20                  25                  30          


Glu Ala Glu Pro Pro Leu Thr Ala Val Leu Val Glu Glu Glu Glu Glu 
        35                  40                  45              


Glu Gly Gly Arg Ala Gly Ala Glu Gly Gly Ala Ala Gly Pro Asp Asp 
    50                  55                  60                  


Gly Gly Val Ala Ala Ala Ser Ser Gly Ser Ala Gln Ala Ala Ser Ser 
65                  70                  75                  80  


Pro Ala Ala Ser Val Gly Thr Gly Val Ala Gly Gly Ala Val Ser Thr 
                85                  90                  95      


Pro Ala Pro Ala Pro Ala Ser Ala Pro Ala Pro Gly Pro Ser Ala Gly 
            100                 105                 110         


Pro Pro Pro Gly Pro Pro Ala Ser Leu Leu Asp Thr Cys Ala Val Cys 
        115                 120                 125             


Gln Gln Ser Leu Gln Ser Arg Arg Glu Ala Glu Pro Lys Leu Leu Pro 
    130                 135                 140                 


Cys Leu His Ser Phe Cys Leu Arg Cys Leu Pro Glu Pro Glu Arg Gln 
145                 150                 155                 160 


Leu Ser Val Pro Ile Pro Gly Gly Ser Asn Gly Asp Ile Gln Gln Val 
                165                 170                 175     


Gly Val Ile Arg Cys Pro Val Cys Arg Gln Glu Cys Arg Gln Ile Asp 
            180                 185                 190         


Leu Val Asp Asn Tyr Phe Val Lys Asp Thr Ser Glu Ala Pro Ser Ser 
        195                 200                 205             


Ser Asp Glu Lys Ser Glu Gln Val Cys Thr Ser Cys Glu Asp Asn Ala 
    210                 215                 220                 


Ser Ala Val Gly Phe Cys Val Glu Cys Gly Glu Trp Leu Cys Lys Thr 
225                 230                 235                 240 


Cys Ile Glu Ala His Gln Arg Val Lys Phe Thr Lys Asp His Leu Ile 
                245                 250                 255     


Arg Lys Lys Glu Asp Val Ser Glu Ser Val Gly Ala Ser Gly Gln Arg 
            260                 265                 270         


Pro Val Phe Cys Pro Val His Lys Gln Glu Gln Leu Lys Leu Phe Cys 
        275                 280                 285             


Glu Thr Cys Asp Arg Leu Thr Cys Arg Asp Cys Gln Leu Leu Glu His 
    290                 295                 300                 


Lys Glu His Arg Tyr Gln Phe Leu Glu Glu Ala Phe Gln Asn Gln Lys 
305                 310                 315                 320 


Gly Ala Ile Glu Asn Leu Leu Ala Lys Leu Leu Glu Lys Lys Asn Tyr 
                325                 330                 335     


Val His Phe Ala Ala Thr Gln Val Gln Asn Arg Ile Lys Glu Val Asn 
            340                 345                 350         


Glu Thr Asn Lys Arg Val Glu Gln Glu Ile Lys Val Ala Ile Phe Thr 
        355                 360                 365             


Leu Ile Asn Glu Ile Asn Lys Lys Gly Lys Ser Leu Leu Gln Gln Leu 
    370                 375                 380                 


Glu Asn Val Thr Lys Glu Arg Gln Met Lys Leu Leu Gln Gln Gln Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Leu Ser Arg Gln Val Lys His Val Met Asn Phe Thr 
                405                 410                 415     


Asn Trp Ala Ile Ala Ser Gly Ser Ser Thr Ala Leu Leu Tyr Ser Lys 
            420                 425                 430         


Arg Leu Ile Thr Phe Gln Leu Arg His Ile Leu Lys Ala Arg Cys Asp 
        435                 440                 445             


Pro Val Pro Ala Ala Asn Gly Ala Ile Arg Phe His Cys Asp Pro Thr 
    450                 455                 460                 


Phe Trp Ala Lys Asn Val Val Asn Leu Gly Asn Leu Val Ile Glu Ser 
465                 470                 475                 480 


Lys Pro Ala Pro Gly Tyr Thr Pro Asn Val Val Val Gly Gln Val Pro 
                485                 490                 495     


Pro Gly Thr Asn His Ile Ser Lys Thr Pro Gly Gln Ile Asn Leu Ala 
            500                 505                 510         


Gln Leu Arg Leu Gln His Met Gln Gln Gln Val Tyr Ala Gln Lys His 
        515                 520                 525             


Gln Gln Leu Gln Gln Met Arg Met Gln Gln Pro Pro Ala Pro Val Pro 
    530                 535                 540                 


Thr Thr Thr Thr Thr Thr Gln Gln His Pro Arg Gln Ala Ala Pro Gln 
545                 550                 555                 560 


Met Leu Gln Gln Gln Pro Pro Arg Leu Ile Ser Val Gln Thr Met Gln 
                565                 570                 575     


Arg Gly Asn Met Asn Cys Gly Ala Phe Gln Ala His Gln Met Arg Leu 
            580                 585                 590         


Ala Gln Asn Ala Ala Arg Ile Pro Gly Ile Pro Arg His Ser Gly Pro 
        595                 600                 605             


Gln Tyr Ser Met Met Gln Pro His Leu Gln Arg Gln His Ser Asn Pro 
    610                 615                 620                 


Gly His Ala Gly Pro Phe Pro Val Val Ser Val His Asn Thr Thr Ile 
625                 630                 635                 640 


Asn Pro Thr Ser Pro Thr Thr Ala Thr Met Ala Asn Ala Asn Arg Gly 
                645                 650                 655     


Pro Thr Ser Pro Ser Val Thr Ala Ile Glu Leu Ile Pro Ser Val Thr 
            660                 665                 670         


Asn Pro Glu Asn Leu Pro Ser Leu Pro Asp Ile Pro Pro Ile Gln Leu 
        675                 680                 685             


Glu Asp Ala Gly Ser Ser Ser Leu Asp Asn Leu Leu Ser Arg Tyr Ile 
    690                 695                 700                 


Ser Gly Ser His Leu Pro Pro Gln Pro Thr Ser Thr Met Asn Pro Ser 
705                 710                 715                 720 


Pro Gly Pro Ser Ala Leu Ser Pro Gly Ser Ser Gly Leu Ser Asn Ser 
                725                 730                 735     


His Thr Pro Val Arg Pro Pro Ser Thr Ser Ser Thr Gly Ser Arg Gly 
            740                 745                 750         


Ser Cys Gly Ser Ser Gly Arg Thr Ala Glu Lys Thr Ser Leu Ser Phe 
        755                 760                 765             


Lys Ser Asp Gln Val Lys Val Lys Gln Glu Pro Gly Thr Glu Asp Glu 
    770                 775                 780                 


Ile Cys Ser Phe Ser Gly Gly Val Lys Gln Glu Lys Thr Glu Asp Gly 
785                 790                 795                 800 


Arg Arg Ser Ala Cys Met Leu Ser Ser Pro Glu Ser Ser Leu Thr Pro 
                805                 810                 815     


Pro Leu Ser Thr Asn Leu His Leu Glu Ser Glu Leu Asp Ala Leu Ala 
            820                 825                 830         


Ser Leu Glu Asn His Val Lys Ile Glu Pro Ala Asp Met Asn Glu Ser 
        835                 840                 845             


Cys Lys Gln Ser Gly Leu Ser Ser Leu Val Asn Gly Lys Ser Pro Ile 
    850                 855                 860                 


Arg Ser Leu Met His Arg Ser Ala Arg Ile Gly Gly Asp Gly Asn Asn 
865                 870                 875                 880 


Lys Asp Asp Asp Pro Asn Glu Asp Trp Cys Ala Val Cys Gln Asn Gly 
                885                 890                 895     


Gly Asp Leu Leu Cys Cys Glu Lys Cys Pro Lys Val Phe His Leu Thr 
            900                 905                 910         


Cys His Val Pro Thr Leu Leu Ser Phe Pro Ser Gly Asp Trp Ile Cys 
        915                 920                 925             


Thr Phe Cys Arg Asp Ile Gly Lys Pro Glu Val Glu Tyr Asp Cys Asp 
    930                 935                 940                 


Asn Leu Gln His Ser Lys Lys Gly Lys Thr Ala Gln Gly Leu Ser Pro 
945                 950                 955                 960 


Val Asp Gln Arg Lys Cys Glu Arg Leu Leu Leu Tyr Leu Tyr Cys His 
                965                 970                 975     


Glu Leu Ser Ile Glu Phe Gln Glu Pro Val Pro Ala Ser Ile Pro Asn 
            980                 985                 990         


Tyr Tyr Lys Ile Ile Lys Lys Pro  Met Asp Leu Ser Thr  Val Lys Lys 
        995                 1000                 1005             


Lys Leu  Gln Lys Lys His Ser  Gln His Tyr Gln Ile  Pro Asp Asp 
    1010                 1015                 1020             


Phe Val  Ala Asp Val Arg Leu  Ile Phe Lys Asn Cys  Glu Arg Phe 
    1025                 1030                 1035             


Asn Glu  Met Met Lys Val Val  Gln Val Tyr Ala Asp  Thr Gln Glu 
    1040                 1045                 1050             


Ile Asn  Leu Lys Ala Asp Ser  Glu Val Ala Gln Ala  Gly Lys Ala 
    1055                 1060                 1065             


Val Ala  Leu Tyr Phe Glu Asp  Lys Leu Thr Glu Ile  Tyr Ser Asp 
    1070                 1075                 1080             


Arg Thr  Phe Ala Pro Leu Pro  Glu Phe Glu Gln Glu  Glu Asp Asp 
    1085                 1090                 1095             


Gly Glu  Val Thr Glu Asp Ser  Asp Glu Asp Phe Ile  Gln Pro Arg 
    1100                 1105                 1110             


Arg Lys  Arg Leu Lys Ser Asp  Glu Arg Pro Val His  Ile Lys 
    1115                 1120                 1125         


<210>  155
<211>  594
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q6UN15
<309>  2016-09-07
<313>  (1)..(594)

<400>  155

Met Ser Ala Gly Glu Val Glu Arg Leu Val Ser Glu Leu Ser Gly Gly 
1               5                   10                  15      


Thr Gly Gly Asp Glu Glu Glu Glu Trp Leu Tyr Gly Gly Pro Trp Asp 
            20                  25                  30          


Val His Val His Ser Asp Leu Ala Lys Asp Leu Asp Glu Asn Glu Val 
        35                  40                  45              


Glu Arg Pro Glu Glu Glu Asn Ala Ser Ala Asn Pro Pro Ser Gly Ile 
    50                  55                  60                  


Glu Asp Glu Thr Ala Glu Asn Gly Val Pro Lys Pro Lys Val Thr Glu 
65                  70                  75                  80  


Thr Glu Asp Asp Ser Asp Ser Asp Ser Asp Asp Asp Glu Asp Asp Val 
                85                  90                  95      


His Val Thr Ile Gly Asp Ile Lys Thr Gly Ala Pro Gln Tyr Gly Ser 
            100                 105                 110         


Tyr Gly Thr Ala Pro Val Asn Leu Asn Ile Lys Thr Gly Gly Arg Val 
        115                 120                 125             


Tyr Gly Thr Thr Gly Thr Lys Val Lys Gly Val Asp Leu Asp Ala Pro 
    130                 135                 140                 


Gly Ser Ile Asn Gly Val Pro Leu Leu Glu Val Asp Leu Asp Ser Phe 
145                 150                 155                 160 


Glu Asp Lys Pro Trp Arg Lys Pro Gly Ala Asp Leu Ser Asp Tyr Phe 
                165                 170                 175     


Asn Tyr Gly Phe Asn Glu Asp Thr Trp Lys Ala Tyr Cys Glu Lys Gln 
            180                 185                 190         


Lys Arg Ile Arg Met Gly Leu Glu Val Ile Pro Val Thr Ser Thr Thr 
        195                 200                 205             


Asn Lys Ile Thr Ala Glu Asp Cys Thr Met Glu Val Thr Pro Gly Ala 
    210                 215                 220                 


Glu Ile Gln Asp Gly Arg Phe Asn Leu Phe Lys Val Gln Gln Gly Arg 
225                 230                 235                 240 


Thr Gly Asn Ser Glu Lys Glu Thr Ala Leu Pro Ser Thr Lys Ala Glu 
                245                 250                 255     


Phe Thr Ser Pro Pro Ser Leu Phe Lys Thr Gly Leu Pro Pro Ser Arg 
            260                 265                 270         


Asn Ser Thr Ser Ser Gln Ser Gln Thr Ser Thr Ala Ser Arg Lys Ala 
        275                 280                 285             


Asn Ser Ser Val Gly Lys Trp Gln Asp Arg Tyr Gly Arg Ala Glu Ser 
    290                 295                 300                 


Pro Asp Leu Arg Arg Leu Pro Gly Ala Ile Asp Val Ile Gly Gln Thr 
305                 310                 315                 320 


Ile Thr Ile Ser Arg Val Glu Gly Arg Arg Arg Ala Asn Glu Asn Ser 
                325                 330                 335     


Asn Ile Gln Val Leu Ser Glu Arg Ser Ala Thr Glu Val Asp Asn Asn 
            340                 345                 350         


Phe Ser Lys Pro Pro Pro Phe Phe Pro Pro Gly Ala Pro Pro Thr His 
        355                 360                 365             


Leu Pro Pro Pro Pro Phe Leu Pro Pro Pro Pro Thr Val Ser Thr Ala 
    370                 375                 380                 


Pro Pro Leu Ile Pro Pro Pro Gly Phe Pro Pro Pro Pro Gly Ala Pro 
385                 390                 395                 400 


Pro Pro Ser Leu Ile Pro Thr Ile Glu Ser Gly His Ser Ser Gly Tyr 
                405                 410                 415     


Asp Ser Arg Ser Ala Arg Ala Phe Pro Tyr Gly Asn Val Ala Phe Pro 
            420                 425                 430         


His Leu Pro Gly Ser Ala Pro Ser Trp Pro Ser Leu Val Asp Thr Ser 
        435                 440                 445             


Lys Gln Trp Asp Tyr Tyr Ala Arg Arg Glu Lys Asp Arg Asp Arg Glu 
    450                 455                 460                 


Arg Asp Arg Asp Arg Glu Arg Asp Arg Asp Arg Asp Arg Glu Arg Glu 
465                 470                 475                 480 


Arg Thr Arg Glu Arg Glu Arg Glu Arg Asp His Ser Pro Thr Pro Ser 
                485                 490                 495     


Val Phe Asn Ser Asp Glu Glu Arg Tyr Arg Tyr Arg Glu Tyr Ala Glu 
            500                 505                 510         


Arg Gly Tyr Glu Arg His Arg Ala Ser Arg Glu Lys Glu Glu Arg His 
        515                 520                 525             


Arg Glu Arg Arg His Arg Glu Lys Glu Glu Thr Arg His Lys Ser Ser 
    530                 535                 540                 


Arg Ser Asn Ser Arg Arg Arg His Glu Ser Glu Glu Gly Asp Ser His 
545                 550                 555                 560 


Arg Arg His Lys His Lys Lys Ser Lys Arg Ser Lys Glu Gly Lys Glu 
                565                 570                 575     


Ala Gly Ser Glu Pro Ala Pro Glu Gln Glu Ser Thr Glu Ala Thr Pro 
            580                 585                 590         


Ala Glu 
        


<210>  156
<211>  271
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9Y5M8
<309>  2016-09-07
<313>  (1)..(271)

<400>  156

Met Ala Ser Ala Asp Ser Arg Arg Val Ala Asp Gly Gly Gly Ala Gly 
1               5                   10                  15      


Gly Thr Phe Gln Pro Tyr Leu Asp Thr Leu Arg Gln Glu Leu Gln Gln 
            20                  25                  30          


Thr Asp Pro Thr Leu Leu Ser Val Val Val Ala Val Leu Ala Val Leu 
        35                  40                  45              


Leu Thr Leu Val Phe Trp Lys Leu Ile Arg Ser Arg Arg Ser Ser Gln 
    50                  55                  60                  


Arg Ala Val Leu Leu Val Gly Leu Cys Asp Ser Gly Lys Thr Leu Leu 
65                  70                  75                  80  


Phe Val Arg Leu Leu Thr Gly Leu Tyr Arg Asp Thr Gln Thr Ser Ile 
                85                  90                  95      


Thr Asp Ser Cys Ala Val Tyr Arg Val Asn Asn Asn Arg Gly Asn Ser 
            100                 105                 110         


Leu Thr Leu Ile Asp Leu Pro Gly His Glu Ser Leu Arg Leu Gln Phe 
        115                 120                 125             


Leu Glu Arg Phe Lys Ser Ser Ala Arg Ala Ile Val Phe Val Val Asp 
    130                 135                 140                 


Ser Ala Ala Phe Gln Arg Glu Val Lys Asp Val Ala Glu Phe Leu Tyr 
145                 150                 155                 160 


Gln Val Leu Ile Asp Ser Met Gly Leu Lys Asn Thr Pro Ser Phe Leu 
                165                 170                 175     


Ile Ala Cys Asn Lys Gln Asp Ile Ala Met Ala Lys Ser Ala Lys Leu 
            180                 185                 190         


Ile Gln Gln Gln Leu Glu Lys Glu Leu Asn Thr Leu Arg Val Thr Arg 
        195                 200                 205             


Ser Ala Ala Pro Ser Thr Leu Asp Ser Ser Ser Thr Ala Pro Ala Gln 
    210                 215                 220                 


Leu Gly Lys Lys Gly Lys Glu Phe Glu Phe Ser Gln Leu Pro Leu Lys 
225                 230                 235                 240 


Val Glu Phe Leu Glu Cys Ser Ala Lys Gly Gly Arg Gly Asp Val Gly 
                245                 250                 255     


Ser Ala Asp Ile Gln Asp Leu Glu Lys Trp Leu Ala Lys Ile Ala 
            260                 265                 270     


<210>  157
<211>  961
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9Y5B0
<309>  2016-09-07
<313>  (1)..(961)

<400>  157

Met Glu Val Pro Ala Ala Gly Arg Val Pro Ala Glu Gly Ala Pro Thr 
1               5                   10                  15      


Ala Ala Val Ala Glu Val Arg Cys Pro Gly Pro Ala Pro Leu Arg Leu 
            20                  25                  30          


Leu Glu Trp Arg Val Ala Ala Gly Ala Ala Val Arg Ile Gly Ser Val 
        35                  40                  45              


Leu Ala Val Phe Glu Ala Ala Ala Ser Ala Gln Ser Ser Gly Ala Ser 
    50                  55                  60                  


Gln Ser Arg Val Ala Ser Gly Gly Cys Val Arg Pro Ala Arg Pro Glu 
65                  70                  75                  80  


Arg Arg Leu Arg Ser Glu Arg Ala Gly Val Val Arg Glu Leu Cys Ala 
                85                  90                  95      


Gln Pro Gly Gln Val Val Ala Pro Gly Ala Val Leu Val Arg Leu Glu 
            100                 105                 110         


Gly Cys Ser His Pro Val Val Met Lys Gly Leu Cys Ala Glu Cys Gly 
        115                 120                 125             


Gln Asp Leu Thr Gln Leu Gln Ser Lys Asn Gly Lys Gln Gln Val Pro 
    130                 135                 140                 


Leu Ser Thr Ala Thr Val Ser Met Val His Ser Val Pro Glu Leu Met 
145                 150                 155                 160 


Val Ser Ser Glu Gln Ala Glu Gln Leu Gly Arg Glu Asp Gln Gln Arg 
                165                 170                 175     


Leu His Arg Asn Arg Lys Leu Val Leu Met Val Asp Leu Asp Gln Thr 
            180                 185                 190         


Leu Ile His Thr Thr Glu Gln His Cys Gln Gln Met Ser Asn Lys Gly 
        195                 200                 205             


Ile Phe His Phe Gln Leu Gly Arg Gly Glu Pro Met Leu His Thr Arg 
    210                 215                 220                 


Leu Arg Pro His Cys Lys Asp Phe Leu Glu Lys Ile Ala Lys Leu Tyr 
225                 230                 235                 240 


Glu Leu His Val Phe Thr Phe Gly Ser Arg Leu Tyr Ala His Thr Ile 
                245                 250                 255     


Ala Gly Phe Leu Asp Pro Glu Lys Lys Leu Phe Ser His Arg Ile Leu 
            260                 265                 270         


Ser Arg Asp Glu Cys Ile Asp Pro Phe Ser Lys Thr Gly Asn Leu Arg 
        275                 280                 285             


Asn Leu Phe Pro Cys Gly Asp Ser Met Val Cys Ile Ile Asp Asp Arg 
    290                 295                 300                 


Glu Asp Val Trp Lys Phe Ala Pro Asn Leu Ile Thr Val Lys Lys Tyr 
305                 310                 315                 320 


Val Tyr Phe Gln Gly Thr Gly Asp Met Asn Ala Pro Pro Gly Ser Arg 
                325                 330                 335     


Glu Ser Gln Thr Arg Lys Lys Val Asn His Ser Arg Gly Thr Glu Val 
            340                 345                 350         


Ser Glu Pro Ser Pro Pro Val Arg Asp Pro Glu Gly Val Thr Gln Ala 
        355                 360                 365             


Pro Gly Val Glu Pro Ser Asn Gly Leu Glu Lys Pro Ala Arg Glu Leu 
    370                 375                 380                 


Asn Gly Ser Glu Ala Ala Thr Pro Arg Asp Ser Pro Arg Pro Gly Lys 
385                 390                 395                 400 


Pro Asp Glu Arg Asp Ile Trp Pro Pro Ala Gln Ala Pro Thr Ser Ser 
                405                 410                 415     


Gln Glu Leu Ala Gly Ala Pro Glu Pro Gln Gly Ser Cys Ala Gln Gly 
            420                 425                 430         


Gly Arg Val Ala Pro Gly Gln Arg Pro Ala Gln Gly Ala Thr Gly Thr 
        435                 440                 445             


Asp Leu Asp Phe Asp Leu Ser Ser Asp Ser Glu Ser Ser Ser Glu Ser 
    450                 455                 460                 


Glu Gly Thr Lys Ser Ser Ser Ser Ala Ser Asp Gly Glu Ser Glu Gly 
465                 470                 475                 480 


Lys Arg Gly Arg Gln Lys Pro Lys Ala Ala Pro Glu Gly Ala Gly Ala 
                485                 490                 495     


Leu Ala Gln Gly Ser Ser Leu Glu Pro Gly Arg Pro Ala Ala Pro Ser 
            500                 505                 510         


Leu Pro Gly Glu Ala Glu Pro Gly Ala His Ala Pro Asp Lys Glu Pro 
        515                 520                 525             


Glu Leu Gly Gly Gln Glu Glu Gly Glu Arg Asp Gly Leu Cys Gly Leu 
    530                 535                 540                 


Gly Asn Gly Cys Ala Asp Arg Lys Glu Ala Glu Thr Glu Ser Gln Asn 
545                 550                 555                 560 


Ser Glu Leu Ser Gly Val Thr Ala Gly Glu Ser Leu Asp Gln Ser Met 
                565                 570                 575     


Glu Glu Glu Glu Glu Glu Asp Thr Asp Glu Asp Asp His Leu Ile Tyr 
            580                 585                 590         


Leu Glu Glu Ile Leu Val Arg Val His Thr Asp Tyr Tyr Ala Lys Tyr 
        595                 600                 605             


Asp Arg Tyr Leu Asn Lys Glu Ile Glu Glu Ala Pro Asp Ile Arg Lys 
    610                 615                 620                 


Ile Val Pro Glu Leu Lys Ser Lys Val Leu Ala Asp Val Ala Ile Ile 
625                 630                 635                 640 


Phe Ser Gly Leu His Pro Thr Asn Phe Pro Ile Glu Lys Thr Arg Glu 
                645                 650                 655     


His Tyr His Ala Thr Ala Leu Gly Ala Lys Ile Leu Thr Arg Leu Val 
            660                 665                 670         


Leu Ser Pro Asp Ala Pro Asp Arg Ala Thr His Leu Ile Ala Ala Arg 
        675                 680                 685             


Ala Gly Thr Glu Lys Val Leu Gln Ala Gln Glu Cys Gly His Leu His 
    690                 695                 700                 


Val Val Asn Pro Asp Trp Leu Trp Ser Cys Leu Glu Arg Trp Asp Lys 
705                 710                 715                 720 


Val Glu Glu Gln Leu Phe Pro Leu Arg Asp Asp His Thr Lys Ala Gln 
                725                 730                 735     


Arg Glu Asn Ser Pro Ala Ala Phe Pro Asp Arg Glu Gly Val Pro Pro 
            740                 745                 750         


Thr Ala Leu Phe His Pro Met Pro Val Leu Pro Lys Ala Gln Pro Gly 
        755                 760                 765             


Pro Glu Val Arg Ile Tyr Asp Ser Asn Thr Gly Lys Leu Ile Arg Thr 
    770                 775                 780                 


Gly Ala Arg Gly Pro Pro Ala Pro Ser Ser Ser Leu Pro Ile Arg Gln 
785                 790                 795                 800 


Glu Pro Ser Ser Phe Arg Ala Val Pro Pro Pro Gln Pro Gln Met Phe 
                805                 810                 815     


Gly Glu Glu Leu Pro Asp Ala Gln Asp Gly Glu Gln Pro Gly Pro Ser 
            820                 825                 830         


Arg Arg Lys Arg Gln Pro Ser Met Ser Glu Thr Met Pro Leu Tyr Thr 
        835                 840                 845             


Leu Cys Lys Glu Asp Leu Glu Ser Met Asp Lys Glu Val Asp Asp Ile 
    850                 855                 860                 


Leu Gly Glu Gly Ser Asp Asp Ser Asp Ser Glu Lys Arg Arg Pro Glu 
865                 870                 875                 880 


Glu Gln Glu Glu Glu Pro Gln Pro Arg Lys Pro Gly Thr Arg Arg Glu 
                885                 890                 895     


Arg Thr Leu Gly Ala Pro Ala Ser Ser Glu Arg Ser Ala Ala Gly Gly 
            900                 905                 910         


Arg Gly Pro Arg Gly His Lys Arg Lys Leu Asn Glu Glu Asp Ala Ala 
        915                 920                 925             


Ser Glu Ser Ser Arg Glu Ser Ser Asn Glu Asp Glu Gly Ser Ser Ser 
    930                 935                 940                 


Glu Ala Asp Glu Met Ala Lys Ala Leu Glu Ala Glu Leu Asn Asp Leu 
945                 950                 955                 960 


Met 
    


<210>  158
<211>  341
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q86W42
<309>  2016-09-07
<313>  (1)..(341)

<400>  158

Met Glu Arg Ala Val Pro Leu Ala Val Pro Leu Gly Gln Thr Glu Val 
1               5                   10                  15      


Phe Gln Ala Leu Gln Arg Leu His Met Thr Ile Phe Ser Gln Ser Val 
            20                  25                  30          


Ser Pro Cys Gly Lys Phe Leu Ala Ala Gly Asn Asn Tyr Gly Gln Ile 
        35                  40                  45              


Ala Ile Phe Ser Leu Ser Ser Ala Leu Ser Ser Glu Ala Lys Glu Glu 
    50                  55                  60                  


Ser Lys Lys Pro Val Val Thr Phe Gln Ala His Asp Gly Pro Val Tyr 
65                  70                  75                  80  


Ser Met Val Ser Thr Asp Arg His Leu Leu Ser Ala Gly Asp Gly Glu 
                85                  90                  95      


Val Lys Ala Trp Leu Trp Ala Glu Met Leu Lys Lys Gly Cys Lys Glu 
            100                 105                 110         


Leu Trp Arg Arg Gln Pro Pro Tyr Arg Thr Ser Leu Glu Val Pro Glu 
        115                 120                 125             


Ile Asn Ala Leu Leu Leu Val Pro Lys Glu Asn Ser Leu Ile Leu Ala 
    130                 135                 140                 


Gly Gly Asp Cys Gln Leu His Thr Met Asp Leu Glu Thr Gly Thr Phe 
145                 150                 155                 160 


Thr Arg Val Leu Arg Gly His Thr Asp Tyr Ile His Cys Leu Ala Leu 
                165                 170                 175     


Arg Glu Arg Ser Pro Glu Val Leu Ser Gly Gly Glu Asp Gly Ala Val 
            180                 185                 190         


Arg Leu Trp Asp Leu Arg Thr Ala Lys Glu Val Gln Thr Ile Glu Val 
        195                 200                 205             


Tyr Lys His Glu Glu Cys Ser Arg Pro His Asn Gly Arg Trp Ile Gly 
    210                 215                 220                 


Cys Leu Ala Thr Asp Ser Asp Trp Met Val Cys Gly Gly Gly Pro Ala 
225                 230                 235                 240 


Leu Thr Leu Trp His Leu Arg Ser Ser Thr Pro Thr Thr Ile Phe Pro 
                245                 250                 255     


Ile Arg Ala Pro Gln Lys His Val Thr Phe Tyr Gln Asp Leu Ile Leu 
            260                 265                 270         


Ser Ala Gly Gln Gly Arg Cys Val Asn Gln Trp Gln Leu Ser Gly Glu 
        275                 280                 285             


Leu Lys Ala Gln Val Pro Gly Ser Ser Pro Gly Leu Leu Ser Leu Ser 
    290                 295                 300                 


Leu Asn Gln Gln Pro Ala Ala Pro Glu Cys Lys Val Leu Thr Ala Ala 
305                 310                 315                 320 


Gly Asn Ser Cys Arg Val Asp Val Phe Thr Asn Leu Gly Tyr Arg Ala 
                325                 330                 335     


Phe Ser Leu Ser Phe 
            340     


<210>  159
<211>  375
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P35659
<309>  2016-09-07
<313>  (1)..(375)

<400>  159

Met Ser Ala Ser Ala Pro Ala Ala Glu Gly Glu Gly Thr Pro Thr Gln 
1               5                   10                  15      


Pro Ala Ser Glu Lys Glu Pro Glu Met Pro Gly Pro Arg Glu Glu Ser 
            20                  25                  30          


Glu Glu Glu Glu Asp Glu Asp Asp Glu Glu Glu Glu Glu Glu Glu Lys 
        35                  40                  45              


Glu Lys Ser Leu Ile Val Glu Gly Lys Arg Glu Lys Lys Lys Val Glu 
    50                  55                  60                  


Arg Leu Thr Met Gln Val Ser Ser Leu Gln Arg Glu Pro Phe Thr Ile 
65                  70                  75                  80  


Ala Gln Gly Lys Gly Gln Lys Leu Cys Glu Ile Glu Arg Ile His Phe 
                85                  90                  95      


Phe Leu Ser Lys Lys Lys Thr Asp Glu Leu Arg Asn Leu His Lys Leu 
            100                 105                 110         


Leu Tyr Asn Arg Pro Gly Thr Val Ser Ser Leu Lys Lys Asn Val Gly 
        115                 120                 125             


Gln Phe Ser Gly Phe Pro Phe Glu Lys Gly Ser Val Gln Tyr Lys Lys 
    130                 135                 140                 


Lys Glu Glu Met Leu Lys Lys Phe Arg Asn Ala Met Leu Lys Ser Ile 
145                 150                 155                 160 


Cys Glu Val Leu Asp Leu Glu Arg Ser Gly Val Asn Ser Glu Leu Val 
                165                 170                 175     


Lys Arg Ile Leu Asn Phe Leu Met His Pro Lys Pro Ser Gly Lys Pro 
            180                 185                 190         


Leu Pro Lys Ser Lys Lys Thr Cys Ser Lys Gly Ser Lys Lys Glu Arg 
        195                 200                 205             


Asn Ser Ser Gly Met Ala Arg Lys Ala Lys Arg Thr Lys Cys Pro Glu 
    210                 215                 220                 


Ile Leu Ser Asp Glu Ser Ser Ser Asp Glu Asp Glu Lys Lys Asn Lys 
225                 230                 235                 240 


Glu Glu Ser Ser Asp Asp Glu Asp Lys Glu Ser Glu Glu Glu Pro Pro 
                245                 250                 255     


Lys Lys Thr Ala Lys Arg Glu Lys Pro Lys Gln Lys Ala Thr Ser Lys 
            260                 265                 270         


Ser Lys Lys Ser Val Lys Ser Ala Asn Val Lys Lys Ala Asp Ser Ser 
        275                 280                 285             


Thr Thr Lys Lys Asn Gln Asn Ser Ser Lys Lys Glu Ser Glu Ser Glu 
    290                 295                 300                 


Asp Ser Ser Asp Asp Glu Pro Leu Ile Lys Lys Leu Lys Lys Pro Pro 
305                 310                 315                 320 


Thr Asp Glu Glu Leu Lys Glu Thr Ile Lys Lys Leu Leu Ala Ser Ala 
                325                 330                 335     


Asn Leu Glu Glu Val Thr Met Lys Gln Ile Cys Lys Lys Val Tyr Glu 
            340                 345                 350         


Asn Tyr Pro Thr Tyr Asp Leu Thr Glu Arg Lys Asp Phe Ile Lys Thr 
        355                 360                 365             


Thr Val Lys Glu Leu Ile Ser 
    370                 375 


<210>  160
<211>  1838
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P20908
<309>  1993-04-23
<313>  (1)..(1838)

<400>  160

Met Asp Val His Thr Arg Trp Lys Ala Arg Ser Ala Leu Arg Pro Gly 
1               5                   10                  15      


Ala Pro Leu Leu Pro Pro Leu Leu Leu Leu Leu Leu Trp Ala Pro Pro 
            20                  25                  30          


Pro Ser Arg Ala Ala Gln Pro Ala Asp Leu Leu Lys Val Leu Asp Phe 
        35                  40                  45              


His Asn Leu Pro Asp Gly Ile Thr Lys Thr Thr Gly Phe Cys Ala Thr 
    50                  55                  60                  


Arg Arg Ser Ser Lys Gly Pro Asp Val Ala Tyr Arg Val Thr Lys Asp 
65                  70                  75                  80  


Ala Gln Leu Ser Ala Pro Thr Lys Gln Leu Tyr Pro Ala Ser Ala Phe 
                85                  90                  95      


Pro Glu Asp Phe Ser Ile Leu Thr Thr Val Lys Ala Lys Lys Gly Ser 
            100                 105                 110         


Gln Ala Phe Leu Val Ser Ile Tyr Asn Glu Gln Gly Ile Gln Gln Ile 
        115                 120                 125             


Gly Leu Glu Leu Gly Arg Ser Pro Val Phe Leu Tyr Glu Asp His Thr 
    130                 135                 140                 


Gly Lys Pro Gly Pro Glu Asp Tyr Pro Leu Phe Arg Gly Ile Asn Leu 
145                 150                 155                 160 


Ser Asp Gly Lys Trp His Arg Ile Ala Leu Ser Val His Lys Lys Asn 
                165                 170                 175     


Val Thr Leu Ile Leu Asp Cys Lys Lys Lys Thr Thr Lys Phe Leu Asp 
            180                 185                 190         


Arg Ser Asp His Pro Met Ile Asp Ile Asn Gly Ile Ile Val Phe Gly 
        195                 200                 205             


Thr Arg Ile Leu Asp Glu Glu Val Phe Glu Gly Asp Ile Gln Gln Leu 
    210                 215                 220                 


Leu Phe Val Ser Asp His Arg Ala Ala Tyr Asp Tyr Cys Glu His Tyr 
225                 230                 235                 240 


Ser Pro Asp Cys Asp Thr Ala Val Pro Asp Thr Pro Gln Ser Gln Asp 
                245                 250                 255     


Pro Asn Pro Asp Glu Tyr Tyr Thr Glu Gly Asp Gly Glu Gly Glu Thr 
            260                 265                 270         


Tyr Tyr Tyr Glu Tyr Pro Tyr Tyr Glu Asp Pro Glu Asp Leu Gly Lys 
        275                 280                 285             


Glu Pro Thr Pro Ser Lys Lys Pro Val Glu Ala Ala Lys Glu Thr Thr 
    290                 295                 300                 


Glu Val Pro Glu Glu Leu Thr Pro Thr Pro Thr Glu Ala Ala Pro Met 
305                 310                 315                 320 


Pro Glu Thr Ser Glu Gly Ala Gly Lys Glu Glu Asp Val Gly Ile Gly 
                325                 330                 335     


Asp Tyr Asp Tyr Val Pro Ser Glu Asp Tyr Tyr Thr Pro Ser Pro Tyr 
            340                 345                 350         


Asp Asp Leu Thr Tyr Gly Glu Gly Glu Glu Asn Pro Asp Gln Pro Thr 
        355                 360                 365             


Asp Pro Gly Ala Gly Ala Glu Ile Pro Thr Ser Thr Ala Asp Thr Ser 
    370                 375                 380                 


Asn Ser Ser Asn Pro Ala Pro Pro Pro Gly Glu Gly Ala Asp Asp Leu 
385                 390                 395                 400 


Glu Gly Glu Phe Thr Glu Glu Thr Ile Arg Asn Leu Asp Glu Asn Tyr 
                405                 410                 415     


Tyr Asp Pro Tyr Tyr Asp Pro Thr Ser Ser Pro Ser Glu Ile Gly Pro 
            420                 425                 430         


Gly Met Pro Ala Asn Gln Asp Thr Ile Tyr Glu Gly Ile Gly Gly Pro 
        435                 440                 445             


Arg Gly Glu Lys Gly Gln Lys Gly Glu Pro Ala Ile Ile Glu Pro Gly 
    450                 455                 460                 


Met Leu Ile Glu Gly Pro Pro Gly Pro Glu Gly Pro Ala Gly Leu Pro 
465                 470                 475                 480 


Gly Pro Pro Gly Thr Met Gly Pro Thr Gly Gln Val Gly Asp Pro Gly 
                485                 490                 495     


Glu Arg Gly Pro Pro Gly Arg Pro Gly Leu Pro Gly Ala Asp Gly Leu 
            500                 505                 510         


Pro Gly Pro Pro Gly Thr Met Leu Met Leu Pro Phe Arg Phe Gly Gly 
        515                 520                 525             


Gly Gly Asp Ala Gly Ser Lys Gly Pro Met Val Ser Ala Gln Glu Ser 
    530                 535                 540                 


Gln Ala Gln Ala Ile Leu Gln Gln Ala Arg Leu Ala Leu Arg Gly Pro 
545                 550                 555                 560 


Ala Gly Pro Met Gly Leu Thr Gly Arg Pro Gly Pro Val Gly Pro Pro 
                565                 570                 575     


Gly Ser Gly Gly Leu Lys Gly Glu Pro Gly Asp Val Gly Pro Gln Gly 
            580                 585                 590         


Pro Arg Gly Val Gln Gly Pro Pro Gly Pro Ala Gly Lys Pro Gly Arg 
        595                 600                 605             


Arg Gly Arg Ala Gly Ser Asp Gly Ala Arg Gly Met Pro Gly Gln Thr 
    610                 615                 620                 


Gly Pro Lys Gly Asp Arg Gly Phe Asp Gly Leu Ala Gly Leu Pro Gly 
625                 630                 635                 640 


Glu Lys Gly His Arg Gly Asp Pro Gly Pro Ser Gly Pro Pro Gly Pro 
                645                 650                 655     


Pro Gly Asp Asp Gly Glu Arg Gly Asp Asp Gly Glu Val Gly Pro Arg 
            660                 665                 670         


Gly Leu Pro Gly Glu Pro Gly Pro Arg Gly Leu Leu Gly Pro Lys Gly 
        675                 680                 685             


Pro Pro Gly Pro Pro Gly Pro Pro Gly Val Thr Gly Met Asp Gly Gln 
    690                 695                 700                 


Pro Gly Pro Lys Gly Asn Val Gly Pro Gln Gly Glu Pro Gly Pro Pro 
705                 710                 715                 720 


Gly Gln Gln Gly Asn Pro Gly Ala Gln Gly Leu Pro Gly Pro Gln Gly 
                725                 730                 735     


Ala Ile Gly Pro Pro Gly Glu Lys Gly Pro Leu Gly Lys Pro Gly Leu 
            740                 745                 750         


Pro Gly Met Pro Gly Ala Asp Gly Pro Pro Gly His Pro Gly Lys Glu 
        755                 760                 765             


Gly Pro Pro Gly Glu Lys Gly Gly Gln Gly Pro Pro Gly Pro Gln Gly 
    770                 775                 780                 


Pro Ile Gly Tyr Pro Gly Pro Arg Gly Val Lys Gly Ala Asp Gly Ile 
785                 790                 795                 800 


Arg Gly Leu Lys Gly Thr Lys Gly Glu Lys Gly Glu Asp Gly Phe Pro 
                805                 810                 815     


Gly Phe Lys Gly Asp Met Gly Ile Lys Gly Asp Arg Gly Glu Ile Gly 
            820                 825                 830         


Pro Pro Gly Pro Arg Gly Glu Asp Gly Pro Glu Gly Pro Lys Gly Arg 
        835                 840                 845             


Gly Gly Pro Asn Gly Asp Pro Gly Pro Leu Gly Pro Pro Gly Glu Lys 
    850                 855                 860                 


Gly Lys Leu Gly Val Pro Gly Leu Pro Gly Tyr Pro Gly Arg Gln Gly 
865                 870                 875                 880 


Pro Lys Gly Ser Ile Gly Phe Pro Gly Phe Pro Gly Ala Asn Gly Glu 
                885                 890                 895     


Lys Gly Gly Arg Gly Thr Pro Gly Lys Pro Gly Pro Arg Gly Gln Arg 
            900                 905                 910         


Gly Pro Thr Gly Pro Arg Gly Glu Arg Gly Pro Arg Gly Ile Thr Gly 
        915                 920                 925             


Lys Pro Gly Pro Lys Gly Asn Ser Gly Gly Asp Gly Pro Ala Gly Pro 
    930                 935                 940                 


Pro Gly Glu Arg Gly Pro Asn Gly Pro Gln Gly Pro Thr Gly Phe Pro 
945                 950                 955                 960 


Gly Pro Lys Gly Pro Pro Gly Pro Pro Gly Lys Asp Gly Leu Pro Gly 
                965                 970                 975     


His Pro Gly Gln Arg Gly Glu Thr Gly Phe Gln Gly Lys Thr Gly Pro 
            980                 985                 990         


Pro Gly Pro Pro Gly Val Val Gly  Pro Gln Gly Pro Thr  Gly Glu Thr 
        995                 1000                 1005             


Gly Pro  Met Gly Glu Arg Gly  His Pro Gly Pro Pro  Gly Pro Pro 
    1010                 1015                 1020             


Gly Glu  Gln Gly Leu Pro Gly  Leu Ala Gly Lys Glu  Gly Thr Lys 
    1025                 1030                 1035             


Gly Asp  Pro Gly Pro Ala Gly  Leu Pro Gly Lys Asp  Gly Pro Pro 
    1040                 1045                 1050             


Gly Leu  Arg Gly Phe Pro Gly  Asp Arg Gly Leu Pro  Gly Pro Val 
    1055                 1060                 1065             


Gly Ala  Leu Gly Leu Lys Gly  Asn Glu Gly Pro Pro  Gly Pro Pro 
    1070                 1075                 1080             


Gly Pro  Ala Gly Ser Pro Gly  Glu Arg Gly Pro Ala  Gly Ala Ala 
    1085                 1090                 1095             


Gly Pro  Ile Gly Ile Pro Gly  Arg Pro Gly Pro Gln  Gly Pro Pro 
    1100                 1105                 1110             


Gly Pro  Ala Gly Glu Lys Gly  Ala Pro Gly Glu Lys  Gly Pro Gln 
    1115                 1120                 1125             


Gly Pro  Ala Gly Arg Asp Gly  Leu Gln Gly Pro Val  Gly Leu Pro 
    1130                 1135                 1140             


Gly Pro  Ala Gly Pro Val Gly  Pro Pro Gly Glu Asp  Gly Asp Lys 
    1145                 1150                 1155             


Gly Glu  Ile Gly Glu Pro Gly  Gln Lys Gly Ser Lys  Gly Asp Lys 
    1160                 1165                 1170             


Gly Glu  Gln Gly Pro Pro Gly  Pro Thr Gly Pro Gln  Gly Pro Ile 
    1175                 1180                 1185             


Gly Gln  Pro Gly Pro Ser Gly  Ala Asp Gly Glu Pro  Gly Pro Arg 
    1190                 1195                 1200             


Gly Gln  Gln Gly Leu Phe Gly  Gln Lys Gly Asp Glu  Gly Pro Arg 
    1205                 1210                 1215             


Gly Phe  Pro Gly Pro Pro Gly  Pro Val Gly Leu Gln  Gly Leu Pro 
    1220                 1225                 1230             


Gly Pro  Pro Gly Glu Lys Gly  Glu Thr Gly Asp Val  Gly Gln Met 
    1235                 1240                 1245             


Gly Pro  Pro Gly Pro Pro Gly  Pro Arg Gly Pro Ser  Gly Ala Pro 
    1250                 1255                 1260             


Gly Ala  Asp Gly Pro Gln Gly  Pro Pro Gly Gly Ile  Gly Asn Pro 
    1265                 1270                 1275             


Gly Ala  Val Gly Glu Lys Gly  Glu Pro Gly Glu Ala  Gly Glu Pro 
    1280                 1285                 1290             


Gly Leu  Pro Gly Glu Gly Gly  Pro Pro Gly Pro Lys  Gly Glu Arg 
    1295                 1300                 1305             


Gly Glu  Lys Gly Glu Ser Gly  Pro Ser Gly Ala Ala  Gly Pro Pro 
    1310                 1315                 1320             


Gly Pro  Lys Gly Pro Pro Gly  Asp Asp Gly Pro Lys  Gly Ser Pro 
    1325                 1330                 1335             


Gly Pro  Val Gly Phe Pro Gly  Asp Pro Gly Pro Pro  Gly Glu Pro 
    1340                 1345                 1350             


Gly Pro  Ala Gly Gln Asp Gly  Pro Pro Gly Asp Lys  Gly Asp Asp 
    1355                 1360                 1365             


Gly Glu  Pro Gly Gln Thr Gly  Ser Pro Gly Pro Thr  Gly Glu Pro 
    1370                 1375                 1380             


Gly Pro  Ser Gly Pro Pro Gly  Lys Arg Gly Pro Pro  Gly Pro Ala 
    1385                 1390                 1395             


Gly Pro  Glu Gly Arg Gln Gly  Glu Lys Gly Ala Lys  Gly Glu Ala 
    1400                 1405                 1410             


Gly Leu  Glu Gly Pro Pro Gly  Lys Thr Gly Pro Ile  Gly Pro Gln 
    1415                 1420                 1425             


Gly Ala  Pro Gly Lys Pro Gly  Pro Asp Gly Leu Arg  Gly Ile Pro 
    1430                 1435                 1440             


Gly Pro  Val Gly Glu Gln Gly  Leu Pro Gly Ser Pro  Gly Pro Asp 
    1445                 1450                 1455             


Gly Pro  Pro Gly Pro Met Gly  Pro Pro Gly Leu Pro  Gly Leu Lys 
    1460                 1465                 1470             


Gly Asp  Ser Gly Pro Lys Gly  Glu Lys Gly His Pro  Gly Leu Ile 
    1475                 1480                 1485             


Gly Leu  Ile Gly Pro Pro Gly  Glu Gln Gly Glu Lys  Gly Asp Arg 
    1490                 1495                 1500             


Gly Leu  Pro Gly Pro Gln Gly  Ser Ser Gly Pro Lys  Gly Glu Gln 
    1505                 1510                 1515             


Gly Ile  Thr Gly Pro Ser Gly  Pro Ile Gly Pro Pro  Gly Pro Pro 
    1520                 1525                 1530             


Gly Leu  Pro Gly Pro Pro Gly  Pro Lys Gly Ala Lys  Gly Ser Ser 
    1535                 1540                 1545             


Gly Pro  Thr Gly Pro Lys Gly  Glu Ala Gly His Pro  Gly Pro Pro 
    1550                 1555                 1560             


Gly Pro  Pro Gly Pro Pro Gly  Glu Val Ile Gln Pro  Leu Pro Ile 
    1565                 1570                 1575             


Gln Ala  Ser Arg Thr Arg Arg  Asn Ile Asp Ala Ser  Gln Leu Leu 
    1580                 1585                 1590             


Asp Asp  Gly Asn Gly Glu Asn  Tyr Val Asp Tyr Ala  Asp Gly Met 
    1595                 1600                 1605             


Glu Glu  Ile Phe Gly Ser Leu  Asn Ser Leu Lys Leu  Glu Ile Glu 
    1610                 1615                 1620             


Gln Met  Lys Arg Pro Leu Gly  Thr Gln Gln Asn Pro  Ala Arg Thr 
    1625                 1630                 1635             


Cys Lys  Asp Leu Gln Leu Cys  His Pro Asp Phe Pro  Asp Gly Glu 
    1640                 1645                 1650             


Tyr Trp  Val Asp Pro Asn Gln  Gly Cys Ser Arg Asp  Ser Phe Lys 
    1655                 1660                 1665             


Val Tyr  Cys Asn Phe Thr Ala  Gly Gly Ser Thr Cys  Val Phe Pro 
    1670                 1675                 1680             


Asp Lys  Lys Ser Glu Gly Ala  Arg Ile Thr Ser Trp  Pro Lys Glu 
    1685                 1690                 1695             


Asn Pro  Gly Ser Trp Phe Ser  Glu Phe Lys Arg Gly  Lys Leu Leu 
    1700                 1705                 1710             


Ser Tyr  Val Asp Ala Glu Gly  Asn Pro Val Gly Val  Val Gln Met 
    1715                 1720                 1725             


Thr Phe  Leu Arg Leu Leu Ser  Ala Ser Ala His Gln  Asn Val Thr 
    1730                 1735                 1740             


Tyr His  Cys Tyr Gln Ser Val  Ala Trp Gln Asp Ala  Ala Thr Gly 
    1745                 1750                 1755             


Ser Tyr  Asp Lys Ala Leu Arg  Phe Leu Gly Ser Asn  Asp Glu Glu 
    1760                 1765                 1770             


Met Ser  Tyr Asp Asn Asn Pro  Tyr Ile Arg Ala Leu  Val Asp Gly 
    1775                 1780                 1785             


Cys Ala  Thr Lys Lys Gly Tyr  Gln Lys Thr Val Leu  Glu Ile Asp 
    1790                 1795                 1800             


Thr Pro  Lys Val Glu Gln Val  Pro Ile Val Asp Ile  Met Phe Asn 
    1805                 1810                 1815             


Asp Phe  Gly Glu Ala Ser Gln  Lys Phe Gly Phe Glu  Val Gly Pro 
    1820                 1825                 1830             


Ala Cys  Phe Met Gly 
    1835             


<210>  161
<211>  546
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O15355
<309>  1998-05-08
<313>  (1)..(546)

<400>  161

Met Gly Ala Tyr Leu Ser Gln Pro Asn Thr Val Lys Cys Ser Gly Asp 
1               5                   10                  15      


Gly Val Gly Ala Pro Arg Leu Pro Leu Pro Tyr Gly Phe Ser Ala Met 
            20                  25                  30          


Gln Gly Trp Arg Val Ser Met Glu Asp Ala His Asn Cys Ile Pro Glu 
        35                  40                  45              


Leu Asp Ser Glu Thr Ala Met Phe Ser Val Tyr Asp Gly His Gly Gly 
    50                  55                  60                  


Glu Glu Val Ala Leu Tyr Cys Ala Lys Tyr Leu Pro Asp Ile Ile Lys 
65                  70                  75                  80  


Asp Gln Lys Ala Tyr Lys Glu Gly Lys Leu Gln Lys Ala Leu Glu Asp 
                85                  90                  95      


Ala Phe Leu Ala Ile Asp Ala Lys Leu Thr Thr Glu Glu Val Ile Lys 
            100                 105                 110         


Glu Leu Ala Gln Ile Ala Gly Arg Pro Thr Glu Asp Glu Asp Glu Lys 
        115                 120                 125             


Glu Lys Val Ala Asp Glu Asp Asp Val Asp Asn Glu Glu Ala Ala Leu 
    130                 135                 140                 


Leu His Glu Glu Ala Thr Met Thr Ile Glu Glu Leu Leu Thr Arg Tyr 
145                 150                 155                 160 


Gly Gln Asn Cys His Lys Gly Pro Pro His Ser Lys Ser Gly Gly Gly 
                165                 170                 175     


Thr Gly Glu Glu Pro Gly Ser Gln Gly Leu Asn Gly Glu Ala Gly Pro 
            180                 185                 190         


Glu Asp Ser Thr Arg Glu Thr Pro Ser Gln Glu Asn Gly Pro Thr Ala 
        195                 200                 205             


Lys Ala Tyr Thr Gly Phe Ser Ser Asn Ser Glu Arg Gly Thr Glu Ala 
    210                 215                 220                 


Gly Gln Val Gly Glu Pro Gly Ile Pro Thr Gly Glu Ala Gly Pro Ser 
225                 230                 235                 240 


Cys Ser Ser Ala Ser Asp Lys Leu Pro Arg Val Ala Lys Ser Lys Phe 
                245                 250                 255     


Phe Glu Asp Ser Glu Asp Glu Ser Asp Glu Ala Glu Glu Glu Glu Glu 
            260                 265                 270         


Asp Ser Glu Glu Cys Ser Glu Glu Glu Asp Gly Tyr Ser Ser Glu Glu 
        275                 280                 285             


Ala Glu Asn Glu Glu Asp Glu Asp Asp Thr Glu Glu Ala Glu Glu Asp 
    290                 295                 300                 


Asp Glu Glu Glu Glu Glu Glu Met Met Val Pro Gly Met Glu Gly Lys 
305                 310                 315                 320 


Glu Glu Pro Gly Ser Asp Ser Gly Thr Thr Ala Val Val Ala Leu Ile 
                325                 330                 335     


Arg Gly Lys Gln Leu Ile Val Ala Asn Ala Gly Asp Ser Arg Cys Val 
            340                 345                 350         


Val Ser Glu Ala Gly Lys Ala Leu Asp Met Ser Tyr Asp His Lys Pro 
        355                 360                 365             


Glu Asp Glu Val Glu Leu Ala Arg Ile Lys Asn Ala Gly Gly Lys Val 
    370                 375                 380                 


Thr Met Asp Gly Arg Val Asn Gly Gly Leu Asn Leu Ser Arg Ala Ile 
385                 390                 395                 400 


Gly Asp His Phe Tyr Lys Arg Asn Lys Asn Leu Pro Pro Glu Glu Gln 
                405                 410                 415     


Met Ile Ser Ala Leu Pro Asp Ile Lys Val Leu Thr Leu Thr Asp Asp 
            420                 425                 430         


His Glu Phe Met Val Ile Ala Cys Asp Gly Ile Trp Asn Val Met Ser 
        435                 440                 445             


Ser Gln Glu Val Val Asp Phe Ile Gln Ser Lys Ile Ser Gln Arg Asp 
    450                 455                 460                 


Glu Asn Gly Glu Leu Arg Leu Leu Ser Ser Ile Val Glu Glu Leu Leu 
465                 470                 475                 480 


Asp Gln Cys Leu Ala Pro Asp Thr Ser Gly Asp Gly Thr Gly Cys Asp 
                485                 490                 495     


Asn Met Thr Cys Ile Ile Ile Cys Phe Lys Pro Arg Asn Thr Ala Glu 
            500                 505                 510         


Leu Gln Pro Glu Ser Gly Lys Arg Lys Leu Glu Glu Val Leu Ser Thr 
        515                 520                 525             


Glu Gly Ala Glu Glu Asn Gly Asn Ser Asp Lys Lys Lys Lys Ala Lys 
    530                 535                 540                 


Arg Asp 
545     


<210>  162
<211>  272
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P13243
<309>  2016-09-07
<313>  (1)..(272)

<400>  162

Met Ser Gly Cys Arg Val Phe Ile Gly Arg Leu Asn Pro Ala Ala Arg 
1               5                   10                  15      


Glu Lys Asp Val Glu Arg Phe Phe Lys Gly Tyr Gly Arg Ile Arg Asp 
            20                  25                  30          


Ile Asp Leu Lys Arg Gly Phe Gly Phe Val Glu Phe Glu Asp Pro Arg 
        35                  40                  45              


Asp Ala Asp Asp Ala Val Tyr Glu Leu Asp Gly Lys Glu Leu Cys Ser 
    50                  55                  60                  


Glu Arg Val Thr Ile Glu His Ala Arg Ala Arg Ser Arg Gly Gly Arg 
65                  70                  75                  80  


Gly Arg Gly Arg Tyr Ser Asp Arg Phe Ser Ser Arg Arg Pro Arg Asn 
                85                  90                  95      


Asp Arg Arg Asn Ala Pro Pro Val Arg Thr Glu Asn Arg Leu Ile Val 
            100                 105                 110         


Glu Asn Leu Ser Ser Arg Val Ser Trp Gln Asp Leu Lys Asp Phe Met 
        115                 120                 125             


Arg Gln Ala Gly Glu Val Thr Phe Ala Asp Ala His Arg Pro Lys Leu 
    130                 135                 140                 


Asn Glu Gly Val Val Glu Phe Ala Ser Tyr Gly Asp Leu Lys Asn Ala 
145                 150                 155                 160 


Ile Glu Lys Leu Ser Gly Lys Glu Ile Asn Gly Arg Lys Ile Lys Leu 
                165                 170                 175     


Ile Glu Gly Ser Lys Arg His Ser Arg Ser Arg Ser Arg Ser Arg Ser 
            180                 185                 190         


Arg Thr Arg Ser Ser Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser 
        195                 200                 205             


Arg Lys Ser Tyr Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Arg 
    210                 215                 220                 


Ser Lys Ser Arg Ser Val Ser Arg Ser Pro Val Pro Glu Lys Ser Gln 
225                 230                 235                 240 


Lys Arg Gly Ser Ser Ser Arg Ser Lys Ser Pro Ala Ser Val Asp Arg 
                245                 250                 255     


Gln Arg Ser Arg Ser Arg Ser Arg Ser Arg Ser Val Asp Ser Gly Asn 
            260                 265                 270         


<210>  163
<211>  246
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P31946
<309>  1993-09-13
<313>  (1)..(246)

<400>  163

Met Thr Met Asp Lys Ser Glu Leu Val Gln Lys Ala Lys Leu Ala Glu 
1               5                   10                  15      


Gln Ala Glu Arg Tyr Asp Asp Met Ala Ala Ala Met Lys Ala Val Thr 
            20                  25                  30          


Glu Gln Gly His Glu Leu Ser Asn Glu Glu Arg Asn Leu Leu Ser Val 
        35                  40                  45              


Ala Tyr Lys Asn Val Val Gly Ala Arg Arg Ser Ser Trp Arg Val Ile 
    50                  55                  60                  


Ser Ser Ile Glu Gln Lys Thr Glu Arg Asn Glu Lys Lys Gln Gln Met 
65                  70                  75                  80  


Gly Lys Glu Tyr Arg Glu Lys Ile Glu Ala Glu Leu Gln Asp Ile Cys 
                85                  90                  95      


Asn Asp Val Leu Glu Leu Leu Asp Lys Tyr Leu Ile Pro Asn Ala Thr 
            100                 105                 110         


Gln Pro Glu Ser Lys Val Phe Tyr Leu Lys Met Lys Gly Asp Tyr Phe 
        115                 120                 125             


Arg Tyr Leu Ser Glu Val Ala Ser Gly Asp Asn Lys Gln Thr Thr Val 
    130                 135                 140                 


Ser Asn Ser Gln Gln Ala Tyr Gln Glu Ala Phe Glu Ile Ser Lys Lys 
145                 150                 155                 160 


Glu Met Gln Pro Thr His Pro Ile Arg Leu Gly Leu Ala Leu Asn Phe 
                165                 170                 175     


Ser Val Phe Tyr Tyr Glu Ile Leu Asn Ser Pro Glu Lys Ala Cys Ser 
            180                 185                 190         


Leu Ala Lys Thr Ala Phe Asp Glu Ala Ile Ala Glu Leu Asp Thr Leu 
        195                 200                 205             


Asn Glu Glu Ser Tyr Lys Asp Ser Thr Leu Ile Met Gln Leu Leu Arg 
    210                 215                 220                 


Asp Asn Leu Thr Leu Trp Thr Ser Glu Asn Gln Gly Asp Glu Gly Asp 
225                 230                 235                 240 


Ala Gly Glu Gly Glu Asn 
                245     


<210>  164
<211>  592
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P27824
<309>  1993-04-23
<313>  (1)..(592)

<400>  164

Met Glu Gly Lys Trp Leu Leu Cys Met Leu Leu Val Leu Gly Thr Ala 
1               5                   10                  15      


Ile Val Glu Ala His Asp Gly His Asp Asp Asp Val Ile Asp Ile Glu 
            20                  25                  30          


Asp Asp Leu Asp Asp Val Ile Glu Glu Val Glu Asp Ser Lys Pro Asp 
        35                  40                  45              


Thr Thr Ala Pro Pro Ser Ser Pro Lys Val Thr Tyr Lys Ala Pro Val 
    50                  55                  60                  


Pro Thr Gly Glu Val Tyr Phe Ala Asp Ser Phe Asp Arg Gly Thr Leu 
65                  70                  75                  80  


Ser Gly Trp Ile Leu Ser Lys Ala Lys Lys Asp Asp Thr Asp Asp Glu 
                85                  90                  95      


Ile Ala Lys Tyr Asp Gly Lys Trp Glu Val Glu Glu Met Lys Glu Ser 
            100                 105                 110         


Lys Leu Pro Gly Asp Lys Gly Leu Val Leu Met Ser Arg Ala Lys His 
        115                 120                 125             


His Ala Ile Ser Ala Lys Leu Asn Lys Pro Phe Leu Phe Asp Thr Lys 
    130                 135                 140                 


Pro Leu Ile Val Gln Tyr Glu Val Asn Phe Gln Asn Gly Ile Glu Cys 
145                 150                 155                 160 


Gly Gly Ala Tyr Val Lys Leu Leu Ser Lys Thr Pro Glu Leu Asn Leu 
                165                 170                 175     


Asp Gln Phe His Asp Lys Thr Pro Tyr Thr Ile Met Phe Gly Pro Asp 
            180                 185                 190         


Lys Cys Gly Glu Asp Tyr Lys Leu His Phe Ile Phe Arg His Lys Asn 
        195                 200                 205             


Pro Lys Thr Gly Ile Tyr Glu Glu Lys His Ala Lys Arg Pro Asp Ala 
    210                 215                 220                 


Asp Leu Lys Thr Tyr Phe Thr Asp Lys Lys Thr His Leu Tyr Thr Leu 
225                 230                 235                 240 


Ile Leu Asn Pro Asp Asn Ser Phe Glu Ile Leu Val Asp Gln Ser Val 
                245                 250                 255     


Val Asn Ser Gly Asn Leu Leu Asn Asp Met Thr Pro Pro Val Asn Pro 
            260                 265                 270         


Ser Arg Glu Ile Glu Asp Pro Glu Asp Arg Lys Pro Glu Asp Trp Asp 
        275                 280                 285             


Glu Arg Pro Lys Ile Pro Asp Pro Glu Ala Val Lys Pro Asp Asp Trp 
    290                 295                 300                 


Asp Glu Asp Ala Pro Ala Lys Ile Pro Asp Glu Glu Ala Thr Lys Pro 
305                 310                 315                 320 


Glu Gly Trp Leu Asp Asp Glu Pro Glu Tyr Val Pro Asp Pro Asp Ala 
                325                 330                 335     


Glu Lys Pro Glu Asp Trp Asp Glu Asp Met Asp Gly Glu Trp Glu Ala 
            340                 345                 350         


Pro Gln Ile Ala Asn Pro Arg Cys Glu Ser Ala Pro Gly Cys Gly Val 
        355                 360                 365             


Trp Gln Arg Pro Val Ile Asp Asn Pro Asn Tyr Lys Gly Lys Trp Lys 
    370                 375                 380                 


Pro Pro Met Ile Asp Asn Pro Ser Tyr Gln Gly Ile Trp Lys Pro Arg 
385                 390                 395                 400 


Lys Ile Pro Asn Pro Asp Phe Phe Glu Asp Leu Glu Pro Phe Arg Met 
                405                 410                 415     


Thr Pro Phe Ser Ala Ile Gly Leu Glu Leu Trp Ser Met Thr Ser Asp 
            420                 425                 430         


Ile Phe Phe Asp Asn Phe Ile Ile Cys Ala Asp Arg Arg Ile Val Asp 
        435                 440                 445             


Asp Trp Ala Asn Asp Gly Trp Gly Leu Lys Lys Ala Ala Asp Gly Ala 
    450                 455                 460                 


Ala Glu Pro Gly Val Val Gly Gln Met Ile Glu Ala Ala Glu Glu Arg 
465                 470                 475                 480 


Pro Trp Leu Trp Val Val Tyr Ile Leu Thr Val Ala Leu Pro Val Phe 
                485                 490                 495     


Leu Val Ile Leu Phe Cys Cys Ser Gly Lys Lys Gln Thr Ser Gly Met 
            500                 505                 510         


Glu Tyr Lys Lys Thr Asp Ala Pro Gln Pro Asp Val Lys Glu Glu Glu 
        515                 520                 525             


Glu Glu Lys Glu Glu Glu Lys Asp Lys Gly Asp Glu Glu Glu Glu Gly 
    530                 535                 540                 


Glu Glu Lys Leu Glu Glu Lys Gln Lys Ser Asp Ala Glu Glu Asp Gly 
545                 550                 555                 560 


Gly Thr Val Ser Gln Glu Glu Glu Asp Arg Lys Pro Lys Ala Glu Glu 
                565                 570                 575     


Asp Glu Ile Leu Asn Arg Ser Pro Arg Asn Arg Lys Pro Arg Arg Glu 
            580                 585                 590         


<210>  165
<211>  372
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P16989
<309>  1993-04-23
<313>  (1)..(372)

<400>  165

Met Ser Glu Ala Gly Glu Ala Thr Thr Thr Thr Thr Thr Thr Leu Pro 
1               5                   10                  15      


Gln Ala Pro Thr Glu Ala Ala Ala Ala Ala Pro Gln Asp Pro Ala Pro 
            20                  25                  30          


Lys Ser Pro Val Gly Ser Gly Ala Pro Gln Ala Ala Ala Pro Ala Pro 
        35                  40                  45              


Ala Ala His Val Ala Gly Asn Pro Gly Gly Asp Ala Ala Pro Ala Ala 
    50                  55                  60                  


Thr Gly Thr Ala Ala Ala Ala Ser Leu Ala Thr Ala Ala Gly Ser Glu 
65                  70                  75                  80  


Asp Ala Glu Lys Lys Val Leu Ala Thr Lys Val Leu Gly Thr Val Lys 
                85                  90                  95      


Trp Phe Asn Val Arg Asn Gly Tyr Gly Phe Ile Asn Arg Asn Asp Thr 
            100                 105                 110         


Lys Glu Asp Val Phe Val His Gln Thr Ala Ile Lys Lys Asn Asn Pro 
        115                 120                 125             


Arg Lys Tyr Leu Arg Ser Val Gly Asp Gly Glu Thr Val Glu Phe Asp 
    130                 135                 140                 


Val Val Glu Gly Glu Lys Gly Ala Glu Ala Ala Asn Val Thr Gly Pro 
145                 150                 155                 160 


Asp Gly Val Pro Val Glu Gly Ser Arg Tyr Ala Ala Asp Arg Arg Arg 
                165                 170                 175     


Tyr Arg Arg Gly Tyr Tyr Gly Arg Arg Arg Gly Pro Pro Arg Asn Tyr 
            180                 185                 190         


Ala Gly Glu Glu Glu Glu Glu Gly Ser Gly Ser Ser Glu Gly Phe Asp 
        195                 200                 205             


Pro Pro Ala Thr Asp Arg Gln Phe Ser Gly Ala Arg Asn Gln Leu Arg 
    210                 215                 220                 


Arg Pro Gln Tyr Arg Pro Gln Tyr Arg Gln Arg Arg Phe Pro Pro Tyr 
225                 230                 235                 240 


His Val Gly Gln Thr Phe Asp Arg Arg Ser Arg Val Leu Pro His Pro 
                245                 250                 255     


Asn Arg Ile Gln Ala Gly Glu Ile Gly Glu Met Lys Asp Gly Val Pro 
            260                 265                 270         


Glu Gly Ala Gln Leu Gln Gly Pro Val His Arg Asn Pro Thr Tyr Arg 
        275                 280                 285             


Pro Arg Tyr Arg Ser Arg Gly Pro Pro Arg Pro Arg Pro Ala Pro Ala 
    290                 295                 300                 


Val Gly Glu Ala Glu Asp Lys Glu Asn Gln Gln Ala Thr Ser Gly Pro 
305                 310                 315                 320 


Asn Gln Pro Ser Val Arg Arg Gly Tyr Arg Arg Pro Tyr Asn Tyr Arg 
                325                 330                 335     


Arg Arg Pro Arg Pro Pro Asn Ala Pro Ser Gln Asp Gly Lys Glu Ala 
            340                 345                 350         


Lys Ala Gly Glu Ala Pro Thr Glu Asn Pro Ala Pro Pro Thr Gln Gln 
        355                 360                 365             


Ser Ser Ala Glu 
    370         


<210>  166
<211>  271
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q96FW1
<309>  2016-09-07
<313>  (1)..(271)

<400>  166

Met Ala Ala Glu Glu Pro Gln Gln Gln Lys Gln Glu Pro Leu Gly Ser 
1               5                   10                  15      


Asp Ser Glu Gly Val Asn Cys Leu Ala Tyr Asp Glu Ala Ile Met Ala 
            20                  25                  30          


Gln Gln Asp Arg Ile Gln Gln Glu Ile Ala Val Gln Asn Pro Leu Val 
        35                  40                  45              


Ser Glu Arg Leu Glu Leu Ser Val Leu Tyr Lys Glu Tyr Ala Glu Asp 
    50                  55                  60                  


Asp Asn Ile Tyr Gln Gln Lys Ile Lys Asp Leu His Lys Lys Tyr Ser 
65                  70                  75                  80  


Tyr Ile Arg Lys Thr Arg Pro Asp Gly Asn Cys Phe Tyr Arg Ala Phe 
                85                  90                  95      


Gly Phe Ser His Leu Glu Ala Leu Leu Asp Asp Ser Lys Glu Leu Gln 
            100                 105                 110         


Arg Phe Lys Ala Val Ser Ala Lys Ser Lys Glu Asp Leu Val Ser Gln 
        115                 120                 125             


Gly Phe Thr Glu Phe Thr Ile Glu Asp Phe His Asn Thr Phe Met Asp 
    130                 135                 140                 


Leu Ile Glu Gln Val Glu Lys Gln Thr Ser Val Ala Asp Leu Leu Ala 
145                 150                 155                 160 


Ser Phe Asn Asp Gln Ser Thr Ser Asp Tyr Leu Val Val Tyr Leu Arg 
                165                 170                 175     


Leu Leu Thr Ser Gly Tyr Leu Gln Arg Glu Ser Lys Phe Phe Glu His 
            180                 185                 190         


Phe Ile Glu Gly Gly Arg Thr Val Lys Glu Phe Cys Gln Gln Glu Val 
        195                 200                 205             


Glu Pro Met Cys Lys Glu Ser Asp His Ile His Ile Ile Ala Leu Ala 
    210                 215                 220                 


Gln Ala Leu Ser Val Ser Ile Gln Val Glu Tyr Met Asp Arg Gly Glu 
225                 230                 235                 240 


Gly Gly Thr Thr Asn Pro His Ile Phe Pro Glu Gly Ser Glu Pro Lys 
                245                 250                 255     


Val Tyr Leu Leu Tyr Arg Pro Gly His Tyr Asp Ile Leu Tyr Lys 
            260                 265                 270     


<210>  167
<211>  462
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P68104
<309>  2016-09-07
<313>  (1)..(462)

<400>  167

Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val 
1               5                   10                  15      


Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Gly 
            20                  25                  30          


Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu 
        35                  40                  45              


Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys 
    50                  55                  60                  


Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe 
65                  70                  75                  80  


Glu Thr Ser Lys Tyr Tyr Val Thr Ile Ile Asp Ala Pro Gly His Arg 
                85                  90                  95      


Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala 
            100                 105                 110         


Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser 
        115                 120                 125             


Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly 
    130                 135                 140                 


Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro 
145                 150                 155                 160 


Pro Tyr Ser Gln Lys Arg Tyr Glu Glu Ile Val Lys Glu Val Ser Thr 
                165                 170                 175     


Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Asp Thr Val Ala Phe Val Pro 
            180                 185                 190         


Ile Ser Gly Trp Asn Gly Asp Asn Met Leu Glu Pro Ser Ala Asn Met 
        195                 200                 205             


Pro Trp Phe Lys Gly Trp Lys Val Thr Arg Lys Asp Gly Asn Ala Ser 
    210                 215                 220                 


Gly Thr Thr Leu Leu Glu Ala Leu Asp Cys Ile Leu Pro Pro Thr Arg 
225                 230                 235                 240 


Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile 
                245                 250                 255     


Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Val Leu 
            260                 265                 270         


Lys Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Val Thr Thr Glu 
        275                 280                 285             


Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro 
    290                 295                 300                 


Gly Asp Asn Val Gly Phe Asn Val Lys Asn Val Ser Val Lys Asp Val 
305                 310                 315                 320 


Arg Arg Gly Asn Val Ala Gly Asp Ser Lys Asn Asp Pro Pro Met Glu 
                325                 330                 335     


Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln 
            340                 345                 350         


Ile Ser Ala Gly Tyr Ala Pro Val Leu Asp Cys His Thr Ala His Ile 
        355                 360                 365             


Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly 
    370                 375                 380                 


Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys Ser Gly Asp Ala Ala 
385                 390                 395                 400 


Ile Val Asp Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser 
                405                 410                 415     


Asp Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg Gln Thr 
            420                 425                 430         


Val Ala Val Gly Val Ile Lys Ala Val Asp Lys Lys Ala Ala Gly Ala 
        435                 440                 445             


Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Lys 
    450                 455                 460         


<210>  168
<211>  462
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q5VTE0
<309>  2016-09-07
<313>  (1)..(462)

<400>  168

Met Gly Lys Glu Lys Thr His Ile Asn Ile Val Val Ile Gly His Val 
1               5                   10                  15      


Asp Ser Gly Lys Ser Thr Thr Thr Gly His Leu Ile Tyr Lys Cys Gly 
            20                  25                  30          


Gly Ile Asp Lys Arg Thr Ile Glu Lys Phe Glu Lys Glu Ala Ala Glu 
        35                  40                  45              


Met Gly Lys Gly Ser Phe Lys Tyr Ala Trp Val Leu Asp Lys Leu Lys 
    50                  55                  60                  


Ala Glu Arg Glu Arg Gly Ile Thr Ile Asp Ile Ser Leu Trp Lys Phe 
65                  70                  75                  80  


Glu Thr Ser Lys Tyr Tyr Val Thr Ile Ile Asp Ala Pro Gly His Arg 
                85                  90                  95      


Asp Phe Ile Lys Asn Met Ile Thr Gly Thr Ser Gln Ala Asp Cys Ala 
            100                 105                 110         


Val Leu Ile Val Ala Ala Gly Val Gly Glu Phe Glu Ala Gly Ile Ser 
        115                 120                 125             


Lys Asn Gly Gln Thr Arg Glu His Ala Leu Leu Ala Tyr Thr Leu Gly 
    130                 135                 140                 


Val Lys Gln Leu Ile Val Gly Val Asn Lys Met Asp Ser Thr Glu Pro 
145                 150                 155                 160 


Pro Tyr Ser Gln Lys Arg Tyr Glu Glu Ile Val Lys Glu Val Ser Thr 
                165                 170                 175     


Tyr Ile Lys Lys Ile Gly Tyr Asn Pro Asp Thr Val Ala Phe Val Pro 
            180                 185                 190         


Ile Ser Gly Trp Asn Gly Asp Asn Met Leu Glu Pro Ser Ala Asn Met 
        195                 200                 205             


Pro Trp Phe Lys Gly Trp Lys Val Thr Arg Lys Asp Gly Asn Ala Ser 
    210                 215                 220                 


Gly Thr Thr Leu Leu Glu Ala Leu Asp Cys Ile Leu Pro Pro Thr Arg 
225                 230                 235                 240 


Pro Thr Asp Lys Pro Leu Arg Leu Pro Leu Gln Asp Val Tyr Lys Ile 
                245                 250                 255     


Gly Gly Ile Gly Thr Val Pro Val Gly Arg Val Glu Thr Gly Val Leu 
            260                 265                 270         


Lys Pro Gly Met Val Val Thr Phe Ala Pro Val Asn Val Thr Thr Glu 
        275                 280                 285             


Val Lys Ser Val Glu Met His His Glu Ala Leu Ser Glu Ala Leu Pro 
    290                 295                 300                 


Gly Asp Asn Val Gly Phe Lys Val Lys Asn Val Ser Val Lys Asp Val 
305                 310                 315                 320 


Arg Arg Gly Asn Val Ala Gly Asp Ser Lys Asn Asp Pro Pro Met Glu 
                325                 330                 335     


Ala Ala Gly Phe Thr Ala Gln Val Ile Ile Leu Asn His Pro Gly Gln 
            340                 345                 350         


Ile Ser Ala Gly Tyr Ala Pro Val Leu Asp Cys His Met Ala His Ile 
        355                 360                 365             


Ala Cys Lys Phe Ala Glu Leu Lys Glu Lys Ile Asp Arg Arg Ser Gly 
    370                 375                 380                 


Lys Lys Leu Glu Asp Gly Pro Lys Phe Leu Lys Ser Gly Asp Ala Ala 
385                 390                 395                 400 


Ile Val Asp Met Val Pro Gly Lys Pro Met Cys Val Glu Ser Phe Ser 
                405                 410                 415     


Asp Tyr Pro Pro Leu Gly Arg Phe Ala Val Arg Asp Met Arg Gln Thr 
            420                 425                 430         


Val Ala Val Gly Val Ile Lys Ala Val Asp Lys Lys Ala Ala Gly Ala 
        435                 440                 445             


Gly Lys Val Thr Lys Ser Ala Gln Lys Ala Gln Lys Ala Lys 
    450                 455                 460         


<210>  169
<211>  589
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P14866
<309>  1993-04-24
<313>  (1)..(589)

<400>  169

Met Ser Arg Arg Leu Leu Pro Arg Ala Glu Lys Arg Arg Arg Arg Leu 
1               5                   10                  15      


Glu Gln Arg Gln Gln Pro Asp Glu Gln Arg Arg Arg Ser Gly Ala Met 
            20                  25                  30          


Val Lys Met Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Arg Tyr Tyr 
        35                  40                  45              


Gly Gly Gly Ser Glu Gly Gly Arg Ala Pro Lys Arg Leu Lys Thr Asp 
    50                  55                  60                  


Asn Ala Gly Asp Gln His Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala 
65                  70                  75                  80  


Gly Ala Ala Gly Gly Gly Gly Gly Gly Glu Asn Tyr Asp Asp Pro His 
                85                  90                  95      


Lys Thr Pro Ala Ser Pro Val Val His Ile Arg Gly Leu Ile Asp Gly 
            100                 105                 110         


Val Val Glu Ala Asp Leu Val Glu Ala Leu Gln Glu Phe Gly Pro Ile 
        115                 120                 125             


Ser Tyr Val Val Val Met Pro Lys Lys Arg Gln Ala Leu Val Glu Phe 
    130                 135                 140                 


Glu Asp Val Leu Gly Ala Cys Asn Ala Val Asn Tyr Ala Ala Asp Asn 
145                 150                 155                 160 


Gln Ile Tyr Ile Ala Gly His Pro Ala Phe Val Asn Tyr Ser Thr Ser 
                165                 170                 175     


Gln Lys Ile Ser Arg Pro Gly Asp Ser Asp Asp Ser Arg Ser Val Asn 
            180                 185                 190         


Ser Val Leu Leu Phe Thr Ile Leu Asn Pro Ile Tyr Ser Ile Thr Thr 
        195                 200                 205             


Asp Val Leu Tyr Thr Ile Cys Asn Pro Cys Gly Pro Val Gln Arg Ile 
    210                 215                 220                 


Val Ile Phe Arg Lys Asn Gly Val Gln Ala Met Val Glu Phe Asp Ser 
225                 230                 235                 240 


Val Gln Ser Ala Gln Arg Ala Lys Ala Ser Leu Asn Gly Ala Asp Ile 
                245                 250                 255     


Tyr Ser Gly Cys Cys Thr Leu Lys Ile Glu Tyr Ala Lys Pro Thr Arg 
            260                 265                 270         


Leu Asn Val Phe Lys Asn Asp Gln Asp Thr Trp Asp Tyr Thr Asn Pro 
        275                 280                 285             


Asn Leu Ser Gly Gln Gly Asp Pro Gly Ser Asn Pro Asn Lys Arg Gln 
    290                 295                 300                 


Arg Gln Pro Pro Leu Leu Gly Asp His Pro Ala Glu Tyr Gly Gly Pro 
305                 310                 315                 320 


His Gly Gly Tyr His Ser His Tyr His Asp Glu Gly Tyr Gly Pro Pro 
                325                 330                 335     


Pro Pro His Tyr Glu Gly Arg Arg Met Gly Pro Pro Val Gly Gly His 
            340                 345                 350         


Arg Arg Gly Pro Ser Arg Tyr Gly Pro Gln Tyr Gly His Pro Pro Pro 
        355                 360                 365             


Pro Pro Pro Pro Pro Glu Tyr Gly Pro His Ala Asp Ser Pro Val Leu 
    370                 375                 380                 


Met Val Tyr Gly Leu Asp Gln Ser Lys Met Asn Cys Asp Arg Val Phe 
385                 390                 395                 400 


Asn Val Phe Cys Leu Tyr Gly Asn Val Glu Lys Val Lys Phe Met Lys 
                405                 410                 415     


Ser Lys Pro Gly Ala Ala Met Val Glu Met Ala Asp Gly Tyr Ala Val 
            420                 425                 430         


Asp Arg Ala Ile Thr His Leu Asn Asn Asn Phe Met Phe Gly Gln Lys 
        435                 440                 445             


Leu Asn Val Cys Val Ser Lys Gln Pro Ala Ile Met Pro Gly Gln Ser 
    450                 455                 460                 


Tyr Gly Leu Glu Asp Gly Ser Cys Ser Tyr Lys Asp Phe Ser Glu Ser 
465                 470                 475                 480 


Arg Asn Asn Arg Phe Ser Thr Pro Glu Gln Ala Ala Lys Asn Arg Ile 
                485                 490                 495     


Gln His Pro Ser Asn Val Leu His Phe Phe Asn Ala Pro Leu Glu Val 
            500                 505                 510         


Thr Glu Glu Asn Phe Phe Glu Ile Cys Asp Glu Leu Gly Val Lys Arg 
        515                 520                 525             


Pro Ser Ser Val Lys Val Phe Ser Gly Lys Ser Glu Arg Ser Ser Ser 
    530                 535                 540                 


Gly Leu Leu Glu Trp Glu Ser Lys Ser Asp Ala Leu Glu Thr Leu Gly 
545                 550                 555                 560 


Phe Leu Asn His Tyr Gln Met Lys Asn Pro Asn Gly Pro Tyr Pro Tyr 
                565                 570                 575     


Thr Leu Lys Leu Cys Phe Ser Thr Ala Gln His Ala Ser 
            580                 585                 


<210>  170
<211>  417
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P27797
<309>  1993-04-23
<313>  (1)..(417)

<400>  170

Met Leu Leu Ser Val Pro Leu Leu Leu Gly Leu Leu Gly Leu Ala Val 
1               5                   10                  15      


Ala Glu Pro Ala Val Tyr Phe Lys Glu Gln Phe Leu Asp Gly Asp Gly 
            20                  25                  30          


Trp Thr Ser Arg Trp Ile Glu Ser Lys His Lys Ser Asp Phe Gly Lys 
        35                  40                  45              


Phe Val Leu Ser Ser Gly Lys Phe Tyr Gly Asp Glu Glu Lys Asp Lys 
    50                  55                  60                  


Gly Leu Gln Thr Ser Gln Asp Ala Arg Phe Tyr Ala Leu Ser Ala Ser 
65                  70                  75                  80  


Phe Glu Pro Phe Ser Asn Lys Gly Gln Thr Leu Val Val Gln Phe Thr 
                85                  90                  95      


Val Lys His Glu Gln Asn Ile Asp Cys Gly Gly Gly Tyr Val Lys Leu 
            100                 105                 110         


Phe Pro Asn Ser Leu Asp Gln Thr Asp Met His Gly Asp Ser Glu Tyr 
        115                 120                 125             


Asn Ile Met Phe Gly Pro Asp Ile Cys Gly Pro Gly Thr Lys Lys Val 
    130                 135                 140                 


His Val Ile Phe Asn Tyr Lys Gly Lys Asn Val Leu Ile Asn Lys Asp 
145                 150                 155                 160 


Ile Arg Cys Lys Asp Asp Glu Phe Thr His Leu Tyr Thr Leu Ile Val 
                165                 170                 175     


Arg Pro Asp Asn Thr Tyr Glu Val Lys Ile Asp Asn Ser Gln Val Glu 
            180                 185                 190         


Ser Gly Ser Leu Glu Asp Asp Trp Asp Phe Leu Pro Pro Lys Lys Ile 
        195                 200                 205             


Lys Asp Pro Asp Ala Ser Lys Pro Glu Asp Trp Asp Glu Arg Ala Lys 
    210                 215                 220                 


Ile Asp Asp Pro Thr Asp Ser Lys Pro Glu Asp Trp Asp Lys Pro Glu 
225                 230                 235                 240 


His Ile Pro Asp Pro Asp Ala Lys Lys Pro Glu Asp Trp Asp Glu Glu 
                245                 250                 255     


Met Asp Gly Glu Trp Glu Pro Pro Val Ile Gln Asn Pro Glu Tyr Lys 
            260                 265                 270         


Gly Glu Trp Lys Pro Arg Gln Ile Asp Asn Pro Asp Tyr Lys Gly Thr 
        275                 280                 285             


Trp Ile His Pro Glu Ile Asp Asn Pro Glu Tyr Ser Pro Asp Pro Ser 
    290                 295                 300                 


Ile Tyr Ala Tyr Asp Asn Phe Gly Val Leu Gly Leu Asp Leu Trp Gln 
305                 310                 315                 320 


Val Lys Ser Gly Thr Ile Phe Asp Asn Phe Leu Ile Thr Asn Asp Glu 
                325                 330                 335     


Ala Tyr Ala Glu Glu Phe Gly Asn Glu Thr Trp Gly Val Thr Lys Ala 
            340                 345                 350         


Ala Glu Lys Gln Met Lys Asp Lys Gln Asp Glu Glu Gln Arg Leu Lys 
        355                 360                 365             


Glu Glu Glu Glu Asp Lys Lys Arg Lys Glu Glu Glu Glu Ala Glu Asp 
    370                 375                 380                 


Lys Glu Asp Asp Glu Asp Lys Asp Glu Asp Glu Glu Asp Glu Glu Asp 
385                 390                 395                 400 


Lys Glu Glu Asp Glu Glu Glu Asp Val Pro Gly Gln Ala Lys Asp Glu 
                405                 410                 415     


Leu 
    


<210>  171
<211>  482
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9UKL0
<309>  2016-09-07
<313>  (1)..(482)

<400>  171

Met Val Glu Lys Gly Pro Glu Val Ser Gly Lys Arg Arg Gly Arg Asn 
1               5                   10                  15      


Asn Ala Ala Ala Ser Ala Ser Ala Ala Ala Ala Ser Ala Ala Ala Ser 
            20                  25                  30          


Ala Ala Cys Ala Ser Pro Ala Ala Thr Ala Ala Ser Gly Ala Ala Ala 
        35                  40                  45              


Ser Ser Ala Ser Ala Ala Ala Ala Ser Ala Ala Ala Ala Pro Asn Asn 
    50                  55                  60                  


Gly Gln Asn Lys Ser Leu Ala Ala Ala Ala Pro Asn Gly Asn Ser Ser 
65                  70                  75                  80  


Ser Asn Ser Trp Glu Glu Gly Ser Ser Gly Ser Ser Ser Asp Glu Glu 
                85                  90                  95      


His Gly Gly Gly Gly Met Arg Val Gly Pro Gln Tyr Gln Ala Val Val 
            100                 105                 110         


Pro Asp Phe Asp Pro Ala Lys Leu Ala Arg Arg Ser Gln Glu Arg Asp 
        115                 120                 125             


Asn Leu Gly Met Leu Val Trp Ser Pro Asn Gln Asn Leu Ser Glu Ala 
    130                 135                 140                 


Lys Leu Asp Glu Tyr Ile Ala Ile Ala Lys Glu Lys His Gly Tyr Asn 
145                 150                 155                 160 


Met Glu Gln Ala Leu Gly Met Leu Phe Trp His Lys His Asn Ile Glu 
                165                 170                 175     


Lys Ser Leu Ala Asp Leu Pro Asn Phe Thr Pro Phe Pro Asp Glu Trp 
            180                 185                 190         


Thr Val Glu Asp Lys Val Leu Phe Glu Gln Ala Phe Ser Phe His Gly 
        195                 200                 205             


Lys Thr Phe His Arg Ile Gln Gln Met Leu Pro Asp Lys Ser Ile Ala 
    210                 215                 220                 


Ser Leu Val Lys Phe Tyr Tyr Ser Trp Lys Lys Thr Arg Thr Lys Thr 
225                 230                 235                 240 


Ser Val Met Asp Arg His Ala Arg Lys Gln Lys Arg Glu Arg Glu Glu 
                245                 250                 255     


Ser Glu Asp Glu Leu Glu Glu Ala Asn Gly Asn Asn Pro Ile Asp Ile 
            260                 265                 270         


Glu Val Asp Gln Asn Lys Glu Ser Lys Lys Glu Val Pro Pro Thr Glu 
        275                 280                 285             


Thr Val Pro Gln Val Lys Lys Glu Lys His Ser Thr Gln Ala Lys Asn 
    290                 295                 300                 


Arg Ala Lys Arg Lys Pro Pro Lys Gly Met Phe Leu Ser Gln Glu Asp 
305                 310                 315                 320 


Val Glu Ala Val Ser Ala Asn Ala Thr Ala Ala Thr Thr Val Leu Arg 
                325                 330                 335     


Gln Leu Asp Met Glu Leu Val Ser Val Lys Arg Gln Ile Gln Asn Ile 
            340                 345                 350         


Lys Gln Thr Asn Ser Ala Leu Lys Glu Lys Leu Asp Gly Gly Ile Glu 
        355                 360                 365             


Pro Tyr Arg Leu Pro Glu Val Ile Gln Lys Cys Asn Ala Arg Trp Thr 
    370                 375                 380                 


Thr Glu Glu Gln Leu Leu Ala Val Gln Ala Ile Arg Lys Tyr Gly Arg 
385                 390                 395                 400 


Asp Phe Gln Ala Ile Ser Asp Val Ile Gly Asn Lys Ser Val Val Gln 
                405                 410                 415     


Val Lys Asn Phe Phe Val Asn Tyr Arg Arg Arg Phe Asn Ile Asp Glu 
            420                 425                 430         


Val Leu Gln Glu Trp Glu Ala Glu His Gly Lys Glu Glu Thr Asn Gly 
        435                 440                 445             


Pro Ser Asn Gln Lys Pro Val Lys Ser Pro Asp Asn Ser Ile Lys Met 
    450                 455                 460                 


Pro Glu Glu Glu Asp Glu Ala Pro Val Leu Asp Val Arg Tyr Ala Ser 
465                 470                 475                 480 


Ala Ser 
        


<210>  172
<211>  427
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P36578
<309>  2016-09-07
<313>  (1)..(427)

<400>  172

Met Ala Cys Ala Arg Pro Leu Ile Ser Val Tyr Ser Glu Lys Gly Glu 
1               5                   10                  15      


Ser Ser Gly Lys Asn Val Thr Leu Pro Ala Val Phe Lys Ala Pro Ile 
            20                  25                  30          


Arg Pro Asp Ile Val Asn Phe Val His Thr Asn Leu Arg Lys Asn Asn 
        35                  40                  45              


Arg Gln Pro Tyr Ala Val Ser Glu Leu Ala Gly His Gln Thr Ser Ala 
    50                  55                  60                  


Glu Ser Trp Gly Thr Gly Arg Ala Val Ala Arg Ile Pro Arg Val Arg 
65                  70                  75                  80  


Gly Gly Gly Thr His Arg Ser Gly Gln Gly Ala Phe Gly Asn Met Cys 
                85                  90                  95      


Arg Gly Gly Arg Met Phe Ala Pro Thr Lys Thr Trp Arg Arg Trp His 
            100                 105                 110         


Arg Arg Val Asn Thr Thr Gln Lys Arg Tyr Ala Ile Cys Ser Ala Leu 
        115                 120                 125             


Ala Ala Ser Ala Leu Pro Ala Leu Val Met Ser Lys Gly His Arg Ile 
    130                 135                 140                 


Glu Glu Val Pro Glu Leu Pro Leu Val Val Glu Asp Lys Val Glu Gly 
145                 150                 155                 160 


Tyr Lys Lys Thr Lys Glu Ala Val Leu Leu Leu Lys Lys Leu Lys Ala 
                165                 170                 175     


Trp Asn Asp Ile Lys Lys Val Tyr Ala Ser Gln Arg Met Arg Ala Gly 
            180                 185                 190         


Lys Gly Lys Met Arg Asn Arg Arg Arg Ile Gln Arg Arg Gly Pro Cys 
        195                 200                 205             


Ile Ile Tyr Asn Glu Asp Asn Gly Ile Ile Lys Ala Phe Arg Asn Ile 
    210                 215                 220                 


Pro Gly Ile Thr Leu Leu Asn Val Ser Lys Leu Asn Ile Leu Lys Leu 
225                 230                 235                 240 


Ala Pro Gly Gly His Val Gly Arg Phe Cys Ile Trp Thr Glu Ser Ala 
                245                 250                 255     


Phe Arg Lys Leu Asp Glu Leu Tyr Gly Thr Trp Arg Lys Ala Ala Ser 
            260                 265                 270         


Leu Lys Ser Asn Tyr Asn Leu Pro Met His Lys Met Ile Asn Thr Asp 
        275                 280                 285             


Leu Ser Arg Ile Leu Lys Ser Pro Glu Ile Gln Arg Ala Leu Arg Ala 
    290                 295                 300                 


Pro Arg Lys Lys Ile His Arg Arg Val Leu Lys Lys Asn Pro Leu Lys 
305                 310                 315                 320 


Asn Leu Arg Ile Met Leu Lys Leu Asn Pro Tyr Ala Lys Thr Met Arg 
                325                 330                 335     


Arg Asn Thr Ile Leu Arg Gln Ala Arg Asn His Lys Leu Arg Val Asp 
            340                 345                 350         


Lys Ala Ala Ala Ala Ala Ala Ala Leu Gln Ala Lys Ser Asp Glu Lys 
        355                 360                 365             


Ala Ala Val Ala Gly Lys Lys Pro Val Val Gly Lys Lys Gly Lys Lys 
    370                 375                 380                 


Ala Ala Val Gly Val Lys Lys Gln Lys Lys Pro Leu Val Gly Lys Lys 
385                 390                 395                 400 


Ala Ala Ala Thr Lys Lys Pro Ala Pro Glu Lys Lys Pro Ala Glu Lys 
                405                 410                 415     


Lys Pro Thr Thr Glu Glu Lys Lys Pro Ala Ala 
            420                 425         


<210>  173
<211>  293
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9BYG3
<309>  2016-09-07
<313>  (1)..(293)

<400>  173

Met Ala Thr Phe Ser Gly Pro Ala Gly Pro Ile Leu Ser Leu Asn Pro 
1               5                   10                  15      


Gln Glu Asp Val Glu Phe Gln Lys Glu Val Ala Gln Val Arg Lys Arg 
            20                  25                  30          


Ile Thr Gln Arg Lys Lys Gln Glu Gln Leu Thr Pro Gly Val Val Tyr 
        35                  40                  45              


Val Arg His Leu Pro Asn Leu Leu Asp Glu Thr Gln Ile Phe Ser Tyr 
    50                  55                  60                  


Phe Ser Gln Phe Gly Thr Val Thr Arg Phe Arg Leu Ser Arg Ser Lys 
65                  70                  75                  80  


Arg Thr Gly Asn Ser Lys Gly Tyr Ala Phe Val Glu Phe Glu Ser Glu 
                85                  90                  95      


Asp Val Ala Lys Ile Val Ala Glu Thr Met Asn Asn Tyr Leu Phe Gly 
            100                 105                 110         


Glu Arg Leu Leu Glu Cys His Phe Met Pro Pro Glu Lys Val His Lys 
        115                 120                 125             


Glu Leu Phe Lys Asp Trp Asn Ile Pro Phe Lys Gln Pro Ser Tyr Pro 
    130                 135                 140                 


Ser Val Lys Arg Tyr Asn Arg Asn Arg Thr Leu Thr Gln Lys Leu Arg 
145                 150                 155                 160 


Met Glu Glu Arg Phe Lys Lys Lys Glu Arg Leu Leu Arg Lys Lys Leu 
                165                 170                 175     


Ala Lys Lys Gly Ile Asp Tyr Asp Phe Pro Ser Leu Ile Leu Gln Lys 
            180                 185                 190         


Thr Glu Ser Ile Ser Lys Thr Asn Arg Gln Thr Ser Thr Lys Gly Gln 
        195                 200                 205             


Val Leu Arg Lys Lys Lys Lys Lys Val Ser Gly Thr Leu Asp Thr Pro 
    210                 215                 220                 


Glu Lys Thr Val Asp Ser Gln Gly Pro Thr Pro Val Cys Thr Pro Thr 
225                 230                 235                 240 


Phe Leu Glu Arg Arg Lys Ser Gln Val Ala Glu Leu Asn Asp Asp Asp 
                245                 250                 255     


Lys Asp Asp Glu Ile Val Phe Lys Gln Pro Ile Ser Cys Val Lys Glu 
            260                 265                 270         


Glu Ile Gln Glu Thr Gln Thr Pro Thr His Ser Arg Lys Lys Arg Arg 
        275                 280                 285             


Arg Ser Ser Asn Gln 
    290             


<210>  174
<211>  338
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P40926
<309>  2016-09-07
<313>  (1)..(338)

<400>  174

Met Leu Ser Ala Leu Ala Arg Pro Ala Ser Ala Ala Leu Arg Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ser Ala Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala 
            20                  25                  30          


Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro 
        35                  40                  45              


Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val 
    50                  55                  60                  


Ala Ala Asp Leu Ser His Ile Glu Thr Lys Ala Ala Val Lys Gly Tyr 
65                  70                  75                  80  


Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val 
                85                  90                  95      


Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp 
            100                 105                 110         


Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys 
        115                 120                 125             


Ala Gln His Cys Pro Glu Ala Met Ile Cys Val Ile Ala Asn Pro Val 
    130                 135                 140                 


Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val 
145                 150                 155                 160 


Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg 
                165                 170                 175     


Ala Asn Thr Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val 
            180                 185                 190         


Asn Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu 
        195                 200                 205             


Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Thr 
    210                 215                 220                 


Ala Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala 
225                 230                 235                 240 


Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala 
                245                 250                 255     


Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val 
            260                 265                 270         


Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Glu Cys Thr Tyr Phe 
        275                 280                 285             


Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly 
    290                 295                 300                 


Ile Gly Lys Val Ser Ser Phe Glu Glu Lys Met Ile Ser Asp Ala Ile 
305                 310                 315                 320 


Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Asp Phe Val Lys Thr 
                325                 330                 335     


Leu Lys 
        


<210>  175
<211>  156
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P62750
<309>  2016-09-07
<313>  (1)..(156)

<400>  175

Met Ala Pro Lys Ala Lys Lys Glu Ala Pro Ala Pro Pro Lys Ala Glu 
1               5                   10                  15      


Ala Lys Ala Lys Ala Leu Lys Ala Lys Lys Ala Val Leu Lys Gly Val 
            20                  25                  30          


His Ser His Lys Lys Lys Lys Ile Arg Thr Ser Pro Thr Phe Arg Arg 
        35                  40                  45              


Pro Lys Thr Leu Arg Leu Arg Arg Gln Pro Lys Tyr Pro Arg Lys Ser 
    50                  55                  60                  


Ala Pro Arg Arg Asn Lys Leu Asp His Tyr Ala Ile Ile Lys Phe Pro 
65                  70                  75                  80  


Leu Thr Thr Glu Ser Ala Met Lys Lys Ile Glu Asp Asn Asn Thr Leu 
                85                  90                  95      


Val Phe Ile Val Asp Val Lys Ala Asn Lys His Gln Ile Lys Gln Ala 
            100                 105                 110         


Val Lys Lys Leu Tyr Asp Ile Asp Val Ala Lys Val Asn Thr Leu Ile 
        115                 120                 125             


Arg Pro Asp Gly Glu Lys Lys Ala Tyr Val Arg Leu Ala Pro Asp Tyr 
    130                 135                 140                 


Asp Ala Leu Asp Val Ala Asn Lys Ile Gly Ile Ile 
145                 150                 155     


<210>  176
<211>  1082
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q8IX01
<309>  2016-09-07
<313>  (1)..(1082)

<400>  176

Met Ala Ala Arg Arg Ile Thr Gln Glu Thr Phe Asp Ala Val Leu Gln 
1               5                   10                  15      


Glu Lys Ala Lys Arg Tyr His Met Asp Ala Ser Gly Glu Ala Val Ser 
            20                  25                  30          


Glu Thr Leu Gln Phe Lys Ala Gln Asp Leu Leu Arg Ala Val Pro Arg 
        35                  40                  45              


Ser Arg Ala Glu Met Tyr Asp Asp Val His Ser Asp Gly Arg Tyr Ser 
    50                  55                  60                  


Leu Ser Gly Ser Val Ala His Ser Arg Asp Ala Gly Arg Glu Gly Leu 
65                  70                  75                  80  


Arg Ser Asp Val Phe Pro Gly Pro Ser Phe Arg Ser Ser Asn Pro Ser 
                85                  90                  95      


Ile Ser Asp Asp Ser Tyr Phe Arg Lys Glu Cys Gly Arg Asp Leu Glu 
            100                 105                 110         


Phe Ser His Ser Asp Ser Arg Asp Gln Val Ile Gly His Arg Lys Leu 
        115                 120                 125             


Gly His Phe Arg Ser Gln Asp Trp Lys Phe Ala Leu Arg Gly Ser Trp 
    130                 135                 140                 


Glu Gln Asp Phe Gly His Pro Val Ser Gln Glu Ser Ser Trp Ser Gln 
145                 150                 155                 160 


Glu Tyr Ser Phe Gly Pro Ser Ala Val Leu Gly Asp Phe Gly Ser Ser 
                165                 170                 175     


Arg Leu Ile Glu Lys Glu Cys Leu Glu Lys Glu Ser Arg Asp Tyr Asp 
            180                 185                 190         


Val Asp His Pro Gly Glu Ala Asp Ser Val Leu Arg Gly Gly Ser Gln 
        195                 200                 205             


Val Gln Ala Arg Gly Arg Ala Leu Asn Ile Val Asp Gln Glu Gly Ser 
    210                 215                 220                 


Leu Leu Gly Lys Gly Glu Thr Gln Gly Leu Leu Thr Ala Lys Gly Gly 
225                 230                 235                 240 


Val Gly Lys Leu Val Thr Leu Arg Asn Val Ser Thr Lys Lys Ile Pro 
                245                 250                 255     


Thr Val Asn Arg Ile Thr Pro Lys Thr Gln Gly Thr Asn Gln Ile Gln 
            260                 265                 270         


Lys Asn Thr Pro Ser Pro Asp Val Thr Leu Gly Thr Asn Pro Gly Thr 
        275                 280                 285             


Glu Asp Ile Gln Phe Pro Ile Gln Lys Ile Pro Leu Gly Leu Asp Leu 
    290                 295                 300                 


Lys Asn Leu Arg Leu Pro Arg Arg Lys Met Ser Phe Asp Ile Ile Asp 
305                 310                 315                 320 


Lys Ser Asp Val Phe Ser Arg Phe Gly Ile Glu Ile Ile Lys Trp Ala 
                325                 330                 335     


Gly Phe His Thr Ile Lys Asp Asp Ile Lys Phe Ser Gln Leu Phe Gln 
            340                 345                 350         


Thr Leu Phe Glu Leu Glu Thr Glu Thr Cys Ala Lys Met Leu Ala Ser 
        355                 360                 365             


Phe Lys Cys Ser Leu Lys Pro Glu His Arg Asp Phe Cys Phe Phe Thr 
    370                 375                 380                 


Ile Lys Phe Leu Lys His Ser Ala Leu Lys Thr Pro Arg Val Asp Asn 
385                 390                 395                 400 


Glu Phe Leu Asn Met Leu Leu Asp Lys Gly Ala Val Lys Thr Lys Asn 
                405                 410                 415     


Cys Phe Phe Glu Ile Ile Lys Pro Phe Asp Lys Tyr Ile Met Arg Leu 
            420                 425                 430         


Gln Asp Arg Leu Leu Lys Ser Val Thr Pro Leu Leu Met Ala Cys Asn 
        435                 440                 445             


Ala Tyr Glu Leu Ser Val Lys Met Lys Thr Leu Ser Asn Pro Leu Asp 
    450                 455                 460                 


Leu Ala Leu Ala Leu Glu Thr Thr Asn Ser Leu Cys Arg Lys Ser Leu 
465                 470                 475                 480 


Ala Leu Leu Gly Gln Thr Phe Ser Leu Ala Ser Ser Phe Arg Gln Glu 
                485                 490                 495     


Lys Ile Leu Glu Ala Val Gly Leu Gln Asp Ile Ala Pro Ser Pro Ala 
            500                 505                 510         


Ala Phe Pro Asn Phe Glu Asp Ser Thr Leu Phe Gly Arg Glu Tyr Ile 
        515                 520                 525             


Asp His Leu Lys Ala Trp Leu Val Ser Ser Gly Cys Pro Leu Gln Val 
    530                 535                 540                 


Lys Lys Ala Glu Pro Glu Pro Met Arg Glu Glu Glu Lys Met Ile Pro 
545                 550                 555                 560 


Pro Thr Lys Pro Glu Ile Gln Ala Lys Ala Pro Ser Ser Leu Ser Asp 
                565                 570                 575     


Ala Val Pro Gln Arg Ala Asp His Arg Val Val Gly Thr Ile Asp Gln 
            580                 585                 590         


Leu Val Lys Arg Val Ile Glu Gly Ser Leu Ser Pro Lys Glu Arg Thr 
        595                 600                 605             


Leu Leu Lys Glu Asp Pro Ala Tyr Trp Phe Leu Ser Asp Glu Asn Ser 
    610                 615                 620                 


Leu Glu Tyr Lys Tyr Tyr Lys Leu Lys Leu Ala Glu Met Gln Arg Met 
625                 630                 635                 640 


Ser Glu Asn Leu Arg Gly Ala Asp Gln Lys Pro Thr Ser Ala Asp Cys 
                645                 650                 655     


Ala Val Arg Ala Met Leu Tyr Ser Arg Ala Val Arg Asn Leu Lys Lys 
            660                 665                 670         


Lys Leu Leu Pro Trp Gln Arg Arg Gly Leu Leu Arg Ala Gln Gly Leu 
        675                 680                 685             


Arg Gly Trp Lys Ala Arg Arg Ala Thr Thr Gly Thr Gln Thr Leu Leu 
    690                 695                 700                 


Ser Ser Gly Thr Arg Leu Lys His His Gly Arg Gln Ala Pro Gly Leu 
705                 710                 715                 720 


Ser Gln Ala Lys Pro Ser Leu Pro Asp Arg Asn Asp Ala Ala Lys Asp 
                725                 730                 735     


Cys Pro Pro Asp Pro Val Gly Pro Ser Pro Gln Asp Pro Ser Leu Glu 
            740                 745                 750         


Ala Ser Gly Pro Ser Pro Lys Pro Ala Gly Val Asp Ile Ser Glu Ala 
        755                 760                 765             


Pro Gln Thr Ser Ser Pro Cys Pro Ser Ala Asp Ile Asp Met Lys Thr 
    770                 775                 780                 


Met Glu Thr Ala Glu Lys Leu Ala Arg Phe Val Ala Gln Val Gly Pro 
785                 790                 795                 800 


Glu Ile Glu Gln Phe Ser Ile Glu Asn Ser Thr Asp Asn Pro Asp Leu 
                805                 810                 815     


Trp Phe Leu His Asp Gln Asn Ser Ser Ala Phe Lys Phe Tyr Arg Lys 
            820                 825                 830         


Lys Val Phe Glu Leu Cys Pro Ser Ile Cys Phe Thr Ser Ser Pro His 
        835                 840                 845             


Asn Leu His Thr Gly Gly Gly Asp Thr Thr Gly Ser Gln Glu Ser Pro 
    850                 855                 860                 


Val Asp Leu Met Glu Gly Glu Ala Glu Phe Glu Asp Glu Pro Pro Pro 
865                 870                 875                 880 


Arg Glu Ala Glu Leu Glu Ser Pro Glu Val Met Pro Glu Glu Glu Asp 
                885                 890                 895     


Glu Asp Asp Glu Asp Gly Gly Glu Glu Ala Pro Ala Pro Gly Gly Ala 
            900                 905                 910         


Gly Lys Ser Glu Gly Ser Thr Pro Ala Asp Gly Leu Pro Gly Glu Ala 
        915                 920                 925             


Ala Glu Asp Asp Leu Ala Gly Ala Pro Ala Leu Ser Gln Ala Ser Ser 
    930                 935                 940                 


Gly Thr Cys Phe Pro Arg Lys Arg Ile Ser Ser Lys Ser Leu Lys Val 
945                 950                 955                 960 


Gly Met Ile Pro Ala Pro Lys Arg Val Cys Leu Ile Gln Glu Pro Lys 
                965                 970                 975     


Val His Glu Pro Val Arg Ile Ala Tyr Asp Arg Pro Arg Gly Arg Pro 
            980                 985                 990         


Met Ser Lys Lys Lys Lys Pro Lys  Asp Leu Asp Phe Ala  Gln Gln Lys 
        995                 1000                 1005             


Leu Thr  Asp Lys Asn Leu Gly  Phe Gln Met Leu Gln  Lys Met Gly 
    1010                 1015                 1020             


Trp Lys  Glu Gly His Gly Leu  Gly Ser Leu Gly Lys  Gly Ile Arg 
    1025                 1030                 1035             


Glu Pro  Val Ser Val Gly Thr  Pro Ser Glu Gly Glu  Gly Leu Gly 
    1040                 1045                 1050             


Ala Asp  Gly Gln Glu His Lys  Glu Asp Thr Phe Asp  Val Phe Arg 
    1055                 1060                 1065             


Gln Arg  Met Met Gln Met Tyr  Arg His Lys Arg Ala  Asn Lys 
    1070                 1075                 1080         


<210>  177
<211>  466
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q15054
<309>  2016-09-07
<313>  (1)..(466)

<400>  177

Met Ala Asp Gln Leu Tyr Leu Glu Asn Ile Asp Glu Phe Val Thr Asp 
1               5                   10                  15      


Gln Asn Lys Ile Val Thr Tyr Lys Trp Leu Ser Tyr Thr Leu Gly Val 
            20                  25                  30          


His Val Asn Gln Ala Lys Gln Met Leu Tyr Asp Tyr Val Glu Arg Lys 
        35                  40                  45              


Arg Lys Glu Asn Ser Gly Ala Gln Leu His Val Thr Tyr Leu Val Ser 
    50                  55                  60                  


Gly Ser Leu Ile Gln Asn Gly His Ser Cys His Lys Val Ala Val Val 
65                  70                  75                  80  


Arg Glu Asp Lys Leu Glu Ala Val Lys Ser Lys Leu Ala Val Thr Ala 
                85                  90                  95      


Ser Ile His Val Tyr Ser Ile Gln Lys Ala Met Leu Lys Asp Ser Gly 
            100                 105                 110         


Pro Leu Phe Asn Thr Asp Tyr Asp Ile Leu Lys Ser Asn Leu Gln Asn 
        115                 120                 125             


Cys Ser Lys Phe Ser Ala Ile Gln Cys Ala Ala Ala Val Pro Arg Ala 
    130                 135                 140                 


Pro Ala Glu Ser Ser Ser Ser Ser Lys Lys Phe Glu Gln Ser His Leu 
145                 150                 155                 160 


His Met Ser Ser Glu Thr Gln Ala Asn Asn Glu Leu Thr Thr Asn Gly 
                165                 170                 175     


His Gly Pro Pro Ala Ser Lys Gln Val Ser Gln Gln Pro Lys Gly Ile 
            180                 185                 190         


Met Gly Met Phe Ala Ser Lys Ala Ala Ala Lys Thr Gln Glu Thr Asn 
        195                 200                 205             


Lys Glu Thr Lys Thr Glu Ala Lys Glu Val Thr Asn Ala Ser Ala Ala 
    210                 215                 220                 


Gly Asn Lys Ala Pro Gly Lys Gly Asn Met Met Ser Asn Phe Phe Gly 
225                 230                 235                 240 


Lys Ala Ala Met Asn Lys Phe Lys Val Asn Leu Asp Ser Glu Gln Ala 
                245                 250                 255     


Val Lys Glu Glu Lys Ile Val Glu Gln Pro Thr Val Ser Val Thr Glu 
            260                 265                 270         


Pro Lys Leu Ala Thr Pro Ala Gly Leu Lys Lys Ser Ser Lys Lys Ala 
        275                 280                 285             


Glu Pro Val Lys Val Leu Gln Lys Glu Lys Lys Arg Gly Lys Arg Val 
    290                 295                 300                 


Ala Leu Ser Asp Asp Glu Thr Lys Glu Thr Glu Asn Met Arg Lys Lys 
305                 310                 315                 320 


Arg Arg Arg Ile Lys Leu Pro Glu Ser Asp Ser Ser Glu Asp Glu Val 
                325                 330                 335     


Phe Pro Asp Ser Pro Gly Ala Tyr Glu Ala Glu Ser Pro Ser Pro Pro 
            340                 345                 350         


Pro Pro Pro Ser Pro Pro Leu Glu Pro Val Pro Lys Thr Glu Pro Glu 
        355                 360                 365             


Pro Pro Ser Val Lys Ser Ser Ser Gly Glu Asn Lys Arg Lys Arg Lys 
    370                 375                 380                 


Arg Val Leu Lys Ser Lys Thr Tyr Leu Asp Gly Glu Gly Cys Ile Val 
385                 390                 395                 400 


Thr Glu Lys Val Tyr Glu Ser Glu Ser Cys Thr Asp Ser Glu Glu Glu 
                405                 410                 415     


Leu Asn Met Lys Thr Ser Ser Val His Arg Pro Pro Ala Met Thr Val 
            420                 425                 430         


Lys Lys Glu Pro Arg Glu Glu Arg Lys Gly Pro Lys Lys Gly Thr Ala 
        435                 440                 445             


Ala Leu Gly Lys Ala Asn Arg Gln Val Ser Ile Thr Gly Phe Phe Gln 
    450                 455                 460                 


Arg Lys 
465     


<210>  178
<211>  577
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P33240
<309>  1994-03-20
<313>  (1)..(577)

<400>  178

Met Ala Gly Leu Thr Val Arg Asp Pro Ala Val Asp Arg Ser Leu Arg 
1               5                   10                  15      


Ser Val Phe Val Gly Asn Ile Pro Tyr Glu Ala Thr Glu Glu Gln Leu 
            20                  25                  30          


Lys Asp Ile Phe Ser Glu Val Gly Pro Val Val Ser Phe Arg Leu Val 
        35                  40                  45              


Tyr Asp Arg Glu Thr Gly Lys Pro Lys Gly Tyr Gly Phe Cys Glu Tyr 
    50                  55                  60                  


Gln Asp Gln Glu Thr Ala Leu Ser Ala Met Arg Asn Leu Asn Gly Arg 
65                  70                  75                  80  


Glu Phe Ser Gly Arg Ala Leu Arg Val Asp Asn Ala Ala Ser Glu Lys 
                85                  90                  95      


Asn Lys Glu Glu Leu Lys Ser Leu Gly Thr Gly Ala Pro Val Ile Glu 
            100                 105                 110         


Ser Pro Tyr Gly Glu Thr Ile Ser Pro Glu Asp Ala Pro Glu Ser Ile 
        115                 120                 125             


Ser Lys Ala Val Ala Ser Leu Pro Pro Glu Gln Met Phe Glu Leu Met 
    130                 135                 140                 


Lys Gln Met Lys Leu Cys Val Gln Asn Ser Pro Gln Glu Ala Arg Asn 
145                 150                 155                 160 


Met Leu Leu Gln Asn Pro Gln Leu Ala Tyr Ala Leu Leu Gln Ala Gln 
                165                 170                 175     


Val Val Met Arg Ile Val Asp Pro Glu Ile Ala Leu Lys Ile Leu His 
            180                 185                 190         


Arg Gln Thr Asn Ile Pro Thr Leu Ile Ala Gly Asn Pro Gln Pro Val 
        195                 200                 205             


His Gly Ala Gly Pro Gly Ser Gly Ser Asn Val Ser Met Asn Gln Gln 
    210                 215                 220                 


Asn Pro Gln Ala Pro Gln Ala Gln Ser Leu Gly Gly Met His Val Asn 
225                 230                 235                 240 


Gly Ala Pro Pro Leu Met Gln Ala Ser Met Gln Gly Gly Val Pro Ala 
                245                 250                 255     


Pro Gly Gln Met Pro Ala Ala Val Thr Gly Pro Gly Pro Gly Ser Leu 
            260                 265                 270         


Ala Pro Gly Gly Gly Met Gln Ala Gln Val Gly Met Pro Gly Ser Gly 
        275                 280                 285             


Pro Val Ser Met Glu Arg Gly Gln Val Pro Met Gln Asp Pro Arg Ala 
    290                 295                 300                 


Ala Met Gln Arg Gly Ser Leu Pro Ala Asn Val Pro Thr Pro Arg Gly 
305                 310                 315                 320 


Leu Leu Gly Asp Ala Pro Asn Asp Pro Arg Gly Gly Thr Leu Leu Ser 
                325                 330                 335     


Val Thr Gly Glu Val Glu Pro Arg Gly Tyr Leu Gly Pro Pro His Gln 
            340                 345                 350         


Gly Pro Pro Met His His Val Pro Gly His Glu Ser Arg Gly Pro Pro 
        355                 360                 365             


Pro His Glu Leu Arg Gly Gly Pro Leu Pro Glu Pro Arg Pro Leu Met 
    370                 375                 380                 


Ala Glu Pro Arg Gly Pro Met Leu Asp Gln Arg Gly Pro Pro Leu Asp 
385                 390                 395                 400 


Gly Arg Gly Gly Arg Asp Pro Arg Gly Ile Asp Ala Arg Gly Met Glu 
                405                 410                 415     


Ala Arg Ala Met Glu Ala Arg Gly Leu Asp Ala Arg Gly Leu Glu Ala 
            420                 425                 430         


Arg Ala Met Glu Ala Arg Ala Met Glu Ala Arg Ala Met Glu Ala Arg 
        435                 440                 445             


Ala Met Glu Ala Arg Ala Met Glu Val Arg Gly Met Glu Ala Arg Gly 
    450                 455                 460                 


Met Asp Thr Arg Gly Pro Val Pro Gly Pro Arg Gly Pro Ile Pro Ser 
465                 470                 475                 480 


Gly Met Gln Gly Pro Ser Pro Ile Asn Met Gly Ala Val Val Pro Gln 
                485                 490                 495     


Gly Ser Arg Gln Val Pro Val Met Gln Gly Thr Gly Met Gln Gly Ala 
            500                 505                 510         


Ser Ile Gln Gly Gly Ser Gln Pro Gly Gly Phe Ser Pro Gly Gln Asn 
        515                 520                 525             


Gln Val Thr Pro Gln Asp His Glu Lys Ala Ala Leu Ile Met Gln Val 
    530                 535                 540                 


Leu Gln Leu Thr Ala Asp Gln Ile Ala Met Leu Pro Pro Glu Gln Arg 
545                 550                 555                 560 


Gln Ser Ile Leu Ile Leu Lys Glu Gln Ile Gln Lys Ser Thr Gly Ala 
                565                 570                 575     


Pro 
    


<210>  179
<211>  244
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q8NBZ0
<309>  2016-09-07
<313>  (1)..(244)

<400>  179

Met Asn Gly Pro Ala Asp Gly Glu Val Asp Tyr Lys Lys Lys Tyr Arg 
1               5                   10                  15      


Asn Leu Lys Arg Lys Leu Lys Phe Leu Ile Tyr Glu His Glu Cys Phe 
            20                  25                  30          


Gln Glu Glu Leu Arg Lys Ala Gln Arg Lys Leu Leu Lys Val Ser Arg 
        35                  40                  45              


Asp Lys Ser Phe Leu Leu Asp Arg Leu Leu Gln Tyr Glu Asn Val Asp 
    50                  55                  60                  


Glu Asp Ser Ser Asp Ser Asp Ala Thr Ala Ser Ser Asp Asn Ser Glu 
65                  70                  75                  80  


Thr Glu Gly Thr Pro Lys Leu Ser Asp Thr Pro Ala Pro Lys Arg Lys 
                85                  90                  95      


Arg Ser Pro Pro Leu Gly Gly Ala Pro Ser Pro Ser Ser Leu Ser Leu 
            100                 105                 110         


Pro Pro Ser Thr Gly Phe Pro Leu Gln Ala Ser Gly Val Pro Ser Pro 
        115                 120                 125             


Tyr Leu Ser Ser Leu Ala Ser Ser Arg Tyr Pro Pro Phe Pro Ser Asp 
    130                 135                 140                 


Tyr Leu Ala Leu Gln Leu Pro Glu Pro Ser Pro Leu Arg Pro Lys Arg 
145                 150                 155                 160 


Glu Lys Arg Pro Arg Leu Pro Arg Lys Leu Lys Met Ala Val Gly Pro 
                165                 170                 175     


Pro Asp Cys Pro Val Gly Gly Pro Leu Thr Phe Pro Gly Arg Gly Ser 
            180                 185                 190         


Gly Ala Gly Val Gly Thr Thr Leu Thr Pro Leu Pro Pro Pro Lys Met 
        195                 200                 205             


Pro Pro Pro Thr Ile Leu Ser Thr Val Pro Arg Gln Met Phe Ser Asp 
    210                 215                 220                 


Ala Gly Ser Gly Asp Asp Ala Leu Asp Gly Asp Asp Asp Leu Val Ile 
225                 230                 235                 240 


Asp Ile Pro Glu 
                


<210>  180
<211>  1297
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q5JTH9
<309>  2016-09-07
<313>  (1)..(1297)

<400>  180

Met Gly Arg Ser Gly Lys Leu Pro Ser Gly Val Ser Ala Lys Leu Lys 
1               5                   10                  15      


Arg Trp Lys Lys Gly His Ser Ser Asp Ser Asn Pro Ala Ile Cys Arg 
            20                  25                  30          


His Arg Gln Ala Ala Arg Ser Arg Phe Phe Ser Arg Pro Ser Gly Arg 
        35                  40                  45              


Ser Asp Leu Thr Val Asp Ala Val Lys Leu His Asn Glu Leu Gln Ser 
    50                  55                  60                  


Gly Ser Leu Arg Leu Gly Lys Ser Glu Ala Pro Glu Thr Pro Met Glu 
65                  70                  75                  80  


Glu Glu Ala Glu Leu Val Leu Thr Glu Lys Ser Ser Gly Thr Phe Leu 
                85                  90                  95      


Ser Gly Leu Ser Asp Cys Thr Asn Val Thr Phe Ser Lys Val Gln Arg 
            100                 105                 110         


Phe Trp Glu Ser Asn Ser Ala Ala His Lys Glu Ile Cys Ala Val Leu 
        115                 120                 125             


Ala Ala Val Thr Glu Val Ile Arg Ser Gln Gly Gly Lys Glu Thr Glu 
    130                 135                 140                 


Thr Glu Tyr Phe Ala Ala Leu Met Thr Thr Met Glu Ala Val Glu Ser 
145                 150                 155                 160 


Pro Glu Ser Leu Ala Ala Val Ala Tyr Leu Leu Asn Leu Val Leu Lys 
                165                 170                 175     


Arg Val Pro Ser Pro Val Leu Ile Lys Lys Phe Ser Asp Thr Ser Lys 
            180                 185                 190         


Ala Phe Met Asp Ile Met Ser Ala Gln Ala Ser Ser Gly Ser Thr Ser 
        195                 200                 205             


Val Leu Arg Trp Val Leu Ser Cys Leu Ala Thr Leu Leu Arg Lys Gln 
    210                 215                 220                 


Asp Leu Glu Ala Trp Gly Tyr Pro Val Thr Leu Gln Val Tyr His Gly 
225                 230                 235                 240 


Leu Leu Ser Phe Thr Val His Pro Lys Pro Lys Ile Arg Lys Ala Ala 
                245                 250                 255     


Gln His Gly Val Cys Ser Val Leu Lys Gly Ser Glu Phe Met Phe Glu 
            260                 265                 270         


Lys Ala Pro Ala His His Pro Ala Ala Ile Ser Thr Ala Lys Phe Cys 
        275                 280                 285             


Ile Gln Glu Ile Glu Lys Ser Gly Gly Ser Lys Glu Ala Thr Thr Thr 
    290                 295                 300                 


Leu His Met Leu Thr Leu Leu Lys Asp Leu Leu Pro Cys Phe Pro Glu 
305                 310                 315                 320 


Gly Leu Val Lys Ser Cys Ser Glu Thr Leu Leu Arg Val Met Thr Leu 
                325                 330                 335     


Ser His Val Leu Val Thr Ala Cys Ala Met Gln Ala Phe His Ser Leu 
            340                 345                 350         


Phe His Ala Arg Pro Gly Leu Ser Thr Leu Ser Ala Glu Leu Asn Ala 
        355                 360                 365             


Gln Ile Ile Thr Ala Leu Tyr Asp Tyr Val Pro Ser Glu Asn Asp Leu 
    370                 375                 380                 


Gln Pro Leu Leu Ala Trp Leu Lys Val Met Glu Lys Ala His Ile Asn 
385                 390                 395                 400 


Leu Val Arg Leu Gln Trp Asp Leu Gly Leu Gly His Leu Pro Arg Phe 
                405                 410                 415     


Phe Gly Thr Ala Val Thr Cys Leu Leu Ser Pro His Ser Gln Val Leu 
            420                 425                 430         


Thr Ala Ala Thr Gln Ser Leu Lys Glu Ile Leu Lys Glu Cys Val Ala 
        435                 440                 445             


Pro His Met Ala Asp Ile Gly Ser Val Thr Ser Ser Ala Ser Gly Pro 
    450                 455                 460                 


Ala Gln Ser Val Ala Lys Met Phe Arg Ala Val Glu Glu Gly Leu Thr 
465                 470                 475                 480 


Tyr Lys Phe His Ala Ala Trp Ser Ser Val Leu Gln Leu Leu Cys Val 
                485                 490                 495     


Phe Phe Glu Ala Cys Gly Arg Gln Ala His Pro Val Met Arg Lys Cys 
            500                 505                 510         


Leu Gln Ser Leu Cys Asp Leu Arg Leu Ser Pro His Phe Pro His Thr 
        515                 520                 525             


Ala Ala Leu Asp Gln Ala Val Gly Ala Ala Val Thr Ser Met Gly Pro 
    530                 535                 540                 


Glu Val Val Leu Gln Ala Val Pro Leu Glu Ile Asp Gly Ser Glu Glu 
545                 550                 555                 560 


Thr Leu Asp Phe Pro Arg Ser Trp Leu Leu Pro Val Ile Arg Asp His 
                565                 570                 575     


Val Gln Glu Thr Arg Leu Gly Phe Phe Thr Thr Tyr Phe Leu Pro Leu 
            580                 585                 590         


Ala Asn Thr Leu Lys Ser Lys Ala Met Asp Leu Ala Gln Ala Gly Ser 
        595                 600                 605             


Thr Val Glu Ser Lys Ile Tyr Asp Thr Leu Gln Trp Gln Met Trp Thr 
    610                 615                 620                 


Leu Leu Pro Gly Phe Cys Thr Arg Pro Thr Asp Val Ala Ile Ser Phe 
625                 630                 635                 640 


Lys Gly Leu Ala Arg Thr Leu Gly Met Ala Ile Ser Glu Arg Pro Asp 
                645                 650                 655     


Leu Arg Val Thr Val Cys Gln Ala Leu Arg Thr Leu Ile Thr Lys Gly 
            660                 665                 670         


Cys Gln Ala Glu Ala Asp Arg Ala Glu Val Ser Arg Phe Ala Lys Asn 
        675                 680                 685             


Phe Leu Pro Ile Leu Phe Asn Leu Tyr Gly Gln Pro Val Ala Ala Gly 
    690                 695                 700                 


Asp Thr Pro Ala Pro Arg Arg Ala Val Leu Glu Thr Ile Arg Thr Tyr 
705                 710                 715                 720 


Leu Thr Ile Thr Asp Thr Gln Leu Val Asn Ser Leu Leu Glu Lys Ala 
                725                 730                 735     


Ser Glu Lys Val Leu Asp Pro Ala Ser Ser Asp Phe Thr Arg Leu Ser 
            740                 745                 750         


Val Leu Asp Leu Val Val Ala Leu Ala Pro Cys Ala Asp Glu Ala Ala 
        755                 760                 765             


Ile Ser Lys Leu Tyr Ser Thr Ile Arg Pro Tyr Leu Glu Ser Lys Ala 
    770                 775                 780                 


His Gly Val Gln Lys Lys Ala Tyr Arg Val Leu Glu Glu Val Cys Ala 
785                 790                 795                 800 


Ser Pro Gln Gly Pro Gly Ala Leu Phe Val Gln Ser His Leu Glu Asp 
                805                 810                 815     


Leu Lys Lys Thr Leu Leu Asp Ser Leu Arg Ser Thr Ser Ser Pro Ala 
            820                 825                 830         


Lys Arg Pro Arg Leu Lys Cys Leu Leu His Ile Val Arg Lys Leu Ser 
        835                 840                 845             


Ala Glu His Lys Glu Phe Ile Thr Ala Leu Ile Pro Glu Val Ile Leu 
    850                 855                 860                 


Cys Thr Lys Glu Val Ser Val Gly Ala Arg Lys Asn Ala Phe Ala Leu 
865                 870                 875                 880 


Leu Val Glu Met Gly His Ala Phe Leu Arg Phe Gly Ser Asn Gln Glu 
                885                 890                 895     


Glu Ala Leu Gln Cys Tyr Leu Val Leu Ile Tyr Pro Gly Leu Val Gly 
            900                 905                 910         


Ala Val Thr Met Val Ser Cys Ser Ile Leu Ala Leu Thr His Leu Leu 
        915                 920                 925             


Phe Glu Phe Lys Gly Leu Met Gly Thr Ser Thr Val Glu Gln Leu Leu 
    930                 935                 940                 


Glu Asn Val Cys Leu Leu Leu Ala Ser Arg Thr Arg Asp Val Val Lys 
945                 950                 955                 960 


Ser Ala Leu Gly Phe Ile Lys Val Ala Val Thr Val Met Asp Val Ala 
                965                 970                 975     


His Leu Ala Lys His Val Gln Leu Val Met Glu Ala Ile Gly Lys Leu 
            980                 985                 990         


Ser Asp Asp Met Arg Arg His Phe  Arg Met Lys Leu Arg  Asn Leu Phe 
        995                 1000                 1005             


Thr Lys  Phe Ile Arg Lys Phe  Gly Phe Glu Leu Val  Lys Arg Leu 
    1010                 1015                 1020             


Leu Pro  Glu Glu Tyr His Arg  Val Leu Val Asn Ile  Arg Lys Ala 
    1025                 1030                 1035             


Glu Ala  Arg Ala Lys Arg His  Arg Ala Leu Ser Gln  Ala Ala Val 
    1040                 1045                 1050             


Glu Glu  Glu Glu Glu Glu Glu  Glu Glu Glu Glu Pro  Ala Gln Gly 
    1055                 1060                 1065             


Lys Gly  Asp Ser Ile Glu Glu  Ile Leu Ala Asp Ser  Glu Asp Glu 
    1070                 1075                 1080             


Glu Asp  Asn Glu Glu Glu Glu  Arg Ser Arg Gly Lys  Glu Gln Arg 
    1085                 1090                 1095             


Lys Leu  Ala Arg Gln Arg Ser  Arg Ala Trp Leu Lys  Glu Gly Gly 
    1100                 1105                 1110             


Gly Asp  Glu Pro Leu Asn Phe  Leu Asp Pro Lys Val  Ala Gln Arg 
    1115                 1120                 1125             


Val Leu  Ala Thr Gln Pro Gly  Pro Gly Arg Gly Arg  Lys Lys Asp 
    1130                 1135                 1140             


His Gly  Phe Lys Val Ser Ala  Asp Gly Arg Leu Ile  Ile Arg Glu 
    1145                 1150                 1155             


Glu Ala  Asp Gly Asn Lys Met  Glu Glu Glu Glu Gly  Ala Lys Gly 
    1160                 1165                 1170             


Glu Asp  Glu Glu Met Ala Asp  Pro Met Glu Asp Val  Ile Ile Arg 
    1175                 1180                 1185             


Asn Lys  Lys His Gln Lys Leu  Lys His Gln Lys Glu  Ala Glu Glu 
    1190                 1195                 1200             


Glu Glu  Leu Glu Ile Pro Pro  Gln Tyr Gln Ala Gly  Gly Ser Gly 
    1205                 1210                 1215             


Ile His  Arg Pro Val Ala Lys  Lys Ala Met Pro Gly  Ala Glu Tyr 
    1220                 1225                 1230             


Lys Ala  Lys Lys Ala Lys Gly  Asp Val Lys Lys Lys  Gly Arg Pro 
    1235                 1240                 1245             


Asp Pro  Tyr Ala Tyr Ile Pro  Leu Asn Arg Ser Lys  Leu Asn Arg 
    1250                 1255                 1260             


Arg Lys  Lys Met Lys Leu Gln  Gly Gln Phe Lys Gly  Leu Val Lys 
    1265                 1270                 1275             


Ala Ala  Arg Arg Gly Ser Gln  Val Gly His Lys Asn  Arg Arg Lys 
    1280                 1285                 1290             


Asp Arg  Arg Pro 
    1295         


<210>  181
<211>  466
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q13283
<309>  2016-09-07
<313>  (1)..(466)

<400>  181

Met Val Met Glu Lys Pro Ser Pro Leu Leu Val Gly Arg Glu Phe Val 
1               5                   10                  15      


Arg Gln Tyr Tyr Thr Leu Leu Asn Gln Ala Pro Asp Met Leu His Arg 
            20                  25                  30          


Phe Tyr Gly Lys Asn Ser Ser Tyr Val His Gly Gly Leu Asp Ser Asn 
        35                  40                  45              


Gly Lys Pro Ala Asp Ala Val Tyr Gly Gln Lys Glu Ile His Arg Lys 
    50                  55                  60                  


Val Met Ser Gln Asn Phe Thr Asn Cys His Thr Lys Ile Arg His Val 
65                  70                  75                  80  


Asp Ala His Ala Thr Leu Asn Asp Gly Val Val Val Gln Val Met Gly 
                85                  90                  95      


Leu Leu Ser Asn Asn Asn Gln Ala Leu Arg Arg Phe Met Gln Thr Phe 
            100                 105                 110         


Val Leu Ala Pro Glu Gly Ser Val Ala Asn Lys Phe Tyr Val His Asn 
        115                 120                 125             


Asp Ile Phe Arg Tyr Gln Asp Glu Val Phe Gly Gly Phe Val Thr Glu 
    130                 135                 140                 


Pro Gln Glu Glu Ser Glu Glu Glu Val Glu Glu Pro Glu Glu Arg Gln 
145                 150                 155                 160 


Gln Thr Pro Glu Val Val Pro Asp Asp Ser Gly Thr Phe Tyr Asp Gln 
                165                 170                 175     


Ala Val Val Ser Asn Asp Met Glu Glu His Leu Glu Glu Pro Val Ala 
            180                 185                 190         


Glu Pro Glu Pro Asp Pro Glu Pro Glu Pro Glu Gln Glu Pro Val Ser 
        195                 200                 205             


Glu Ile Gln Glu Glu Lys Pro Glu Pro Val Leu Glu Glu Thr Ala Pro 
    210                 215                 220                 


Glu Asp Ala Gln Lys Ser Ser Ser Pro Ala Pro Ala Asp Ile Ala Gln 
225                 230                 235                 240 


Thr Val Gln Glu Asp Leu Arg Thr Phe Ser Trp Ala Ser Val Thr Ser 
                245                 250                 255     


Lys Asn Leu Pro Pro Ser Gly Ala Val Pro Val Thr Gly Ile Pro Pro 
            260                 265                 270         


His Val Val Lys Val Pro Ala Ser Gln Pro Arg Pro Glu Ser Lys Pro 
        275                 280                 285             


Glu Ser Gln Ile Pro Pro Gln Arg Pro Gln Arg Asp Gln Arg Val Arg 
    290                 295                 300                 


Glu Gln Arg Ile Asn Ile Pro Pro Gln Arg Gly Pro Arg Pro Ile Arg 
305                 310                 315                 320 


Glu Ala Gly Glu Gln Gly Asp Ile Glu Pro Arg Arg Met Val Arg His 
                325                 330                 335     


Pro Asp Ser His Gln Leu Phe Ile Gly Asn Leu Pro His Glu Val Asp 
            340                 345                 350         


Lys Ser Glu Leu Lys Asp Phe Phe Gln Ser Tyr Gly Asn Val Val Glu 
        355                 360                 365             


Leu Arg Ile Asn Ser Gly Gly Lys Leu Pro Asn Phe Gly Phe Val Val 
    370                 375                 380                 


Phe Asp Asp Ser Glu Pro Val Gln Lys Val Leu Ser Asn Arg Pro Ile 
385                 390                 395                 400 


Met Phe Arg Gly Glu Val Arg Leu Asn Val Glu Glu Lys Lys Thr Arg 
                405                 410                 415     


Ala Ala Arg Glu Gly Asp Arg Arg Asp Asn Arg Leu Arg Gly Pro Gly 
            420                 425                 430         


Gly Pro Arg Gly Gly Leu Gly Gly Gly Met Arg Gly Pro Pro Arg Gly 
        435                 440                 445             


Gly Met Val Gln Lys Pro Gly Phe Gly Val Gly Arg Gly Leu Ala Pro 
    450                 455                 460                 


Arg Gln 
465     


<210>  182
<211>  2285
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O14497
<309>  2001-02-01
<313>  (1)..(2285)

<400>  182

Met Ala Ala Gln Val Ala Pro Ala Ala Ala Ser Ser Leu Gly Asn Pro 
1               5                   10                  15      


Pro Pro Pro Pro Pro Ser Glu Leu Lys Lys Ala Glu Gln Gln Gln Arg 
            20                  25                  30          


Glu Glu Ala Gly Gly Glu Ala Ala Ala Ala Ala Ala Ala Glu Arg Gly 
        35                  40                  45              


Glu Met Lys Ala Ala Ala Gly Gln Glu Ser Glu Gly Pro Ala Val Gly 
    50                  55                  60                  


Pro Pro Gln Pro Leu Gly Lys Glu Leu Gln Asp Gly Ala Glu Ser Asn 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Ala Gly Ser Gly Gly Gly Pro Gly Ala 
                85                  90                  95      


Glu Pro Asp Leu Lys Asn Ser Asn Gly Asn Ala Gly Pro Arg Pro Ala 
            100                 105                 110         


Leu Asn Asn Asn Leu Thr Glu Pro Pro Gly Gly Gly Gly Gly Gly Ser 
        115                 120                 125             


Ser Asp Gly Val Gly Ala Pro Pro His Ser Ala Ala Ala Ala Leu Pro 
    130                 135                 140                 


Pro Pro Ala Tyr Gly Phe Gly Gln Pro Tyr Gly Arg Ser Pro Ser Ala 
145                 150                 155                 160 


Val Ala Ala Ala Ala Ala Ala Val Phe His Gln Gln His Gly Gly Gln 
                165                 170                 175     


Gln Ser Pro Gly Leu Ala Ala Leu Gln Ser Gly Gly Gly Gly Gly Leu 
            180                 185                 190         


Glu Pro Tyr Ala Gly Pro Gln Gln Asn Ser His Asp His Gly Phe Pro 
        195                 200                 205             


Asn His Gln Tyr Asn Ser Tyr Tyr Pro Asn Arg Ser Ala Tyr Pro Pro 
    210                 215                 220                 


Pro Ala Pro Ala Tyr Ala Leu Ser Ser Pro Arg Gly Gly Thr Pro Gly 
225                 230                 235                 240 


Ser Gly Ala Ala Ala Ala Ala Gly Ser Lys Pro Pro Pro Ser Ser Ser 
                245                 250                 255     


Ala Ser Ala Ser Ser Ser Ser Ser Ser Phe Ala Gln Gln Arg Phe Gly 
            260                 265                 270         


Ala Met Gly Gly Gly Gly Pro Ser Ala Ala Gly Gly Gly Thr Pro Gln 
        275                 280                 285             


Pro Thr Ala Thr Pro Thr Leu Asn Gln Leu Leu Thr Ser Pro Ser Ser 
    290                 295                 300                 


Ala Arg Gly Tyr Gln Gly Tyr Pro Gly Gly Asp Tyr Ser Gly Gly Pro 
305                 310                 315                 320 


Gln Asp Gly Gly Ala Gly Lys Gly Pro Ala Asp Met Ala Ser Gln Cys 
                325                 330                 335     


Trp Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gly Gly 
            340                 345                 350         


Ala Gln Gln Arg Ser His His Ala Pro Met Ser Pro Gly Ser Ser Gly 
        355                 360                 365             


Gly Gly Gly Gln Pro Leu Ala Arg Thr Pro Gln Pro Ser Ser Pro Met 
    370                 375                 380                 


Asp Gln Met Gly Lys Met Arg Pro Gln Pro Tyr Gly Gly Thr Asn Pro 
385                 390                 395                 400 


Tyr Ser Gln Gln Gln Gly Pro Pro Ser Gly Pro Gln Gln Gly His Gly 
                405                 410                 415     


Tyr Pro Gly Gln Pro Tyr Gly Ser Gln Thr Pro Gln Arg Tyr Pro Met 
            420                 425                 430         


Thr Met Gln Gly Arg Ala Gln Ser Ala Met Gly Gly Leu Ser Tyr Thr 
        435                 440                 445             


Gln Gln Ile Pro Pro Tyr Gly Gln Gln Gly Pro Ser Gly Tyr Gly Gln 
    450                 455                 460                 


Gln Gly Gln Thr Pro Tyr Tyr Asn Gln Gln Ser Pro His Pro Gln Gln 
465                 470                 475                 480 


Gln Gln Pro Pro Tyr Ser Gln Gln Pro Pro Ser Gln Thr Pro His Ala 
                485                 490                 495     


Gln Pro Ser Tyr Gln Gln Gln Pro Gln Ser Gln Pro Pro Gln Leu Gln 
            500                 505                 510         


Ser Ser Gln Pro Pro Tyr Ser Gln Gln Pro Ser Gln Pro Pro His Gln 
        515                 520                 525             


Gln Ser Pro Ala Pro Tyr Pro Ser Gln Gln Ser Thr Thr Gln Gln His 
    530                 535                 540                 


Pro Gln Ser Gln Pro Pro Tyr Ser Gln Pro Gln Ala Gln Ser Pro Tyr 
545                 550                 555                 560 


Gln Gln Gln Gln Pro Gln Gln Pro Ala Pro Ser Thr Leu Ser Gln Gln 
                565                 570                 575     


Ala Ala Tyr Pro Gln Pro Gln Ser Gln Gln Ser Gln Gln Thr Ala Tyr 
            580                 585                 590         


Ser Gln Gln Arg Phe Pro Pro Pro Gln Glu Leu Ser Gln Asp Ser Phe 
        595                 600                 605             


Gly Ser Gln Ala Ser Ser Ala Pro Ser Met Thr Ser Ser Lys Gly Gly 
    610                 615                 620                 


Gln Glu Asp Met Asn Leu Ser Leu Gln Ser Arg Pro Ser Ser Leu Pro 
625                 630                 635                 640 


Asp Leu Ser Gly Ser Ile Asp Asp Leu Pro Met Gly Thr Glu Gly Ala 
                645                 650                 655     


Leu Ser Pro Gly Val Ser Thr Ser Gly Ile Ser Ser Ser Gln Gly Glu 
            660                 665                 670         


Gln Ser Asn Pro Ala Gln Ser Pro Phe Ser Pro His Thr Ser Pro His 
        675                 680                 685             


Leu Pro Gly Ile Arg Gly Pro Ser Pro Ser Pro Val Gly Ser Pro Ala 
    690                 695                 700                 


Ser Val Ala Gln Ser Arg Ser Gly Pro Leu Ser Pro Ala Ala Val Pro 
705                 710                 715                 720 


Gly Asn Gln Met Pro Pro Arg Pro Pro Ser Gly Gln Ser Asp Ser Ile 
                725                 730                 735     


Met His Pro Ser Met Asn Gln Ser Ser Ile Ala Gln Asp Arg Gly Tyr 
            740                 745                 750         


Met Gln Arg Asn Pro Gln Met Pro Gln Tyr Ser Ser Pro Gln Pro Gly 
        755                 760                 765             


Ser Ala Leu Ser Pro Arg Gln Pro Ser Gly Gly Gln Ile His Thr Gly 
    770                 775                 780                 


Met Gly Ser Tyr Gln Gln Asn Ser Met Gly Ser Tyr Gly Pro Gln Gly 
785                 790                 795                 800 


Gly Gln Tyr Gly Pro Gln Gly Gly Tyr Pro Arg Gln Pro Asn Tyr Asn 
                805                 810                 815     


Ala Leu Pro Asn Ala Asn Tyr Pro Ser Ala Gly Met Ala Gly Gly Ile 
            820                 825                 830         


Asn Pro Met Gly Ala Gly Gly Gln Met His Gly Gln Pro Gly Ile Pro 
        835                 840                 845             


Pro Tyr Gly Thr Leu Pro Pro Gly Arg Met Ser His Ala Ser Met Gly 
    850                 855                 860                 


Asn Arg Pro Tyr Gly Pro Asn Met Ala Asn Met Pro Pro Gln Val Gly 
865                 870                 875                 880 


Ser Gly Met Cys Pro Pro Pro Gly Gly Met Asn Arg Lys Thr Gln Glu 
                885                 890                 895     


Thr Ala Val Ala Met His Val Ala Ala Asn Ser Ile Gln Asn Arg Pro 
            900                 905                 910         


Pro Gly Tyr Pro Asn Met Asn Gln Gly Gly Met Met Gly Thr Gly Pro 
        915                 920                 925             


Pro Tyr Gly Gln Gly Ile Asn Ser Met Ala Gly Met Ile Asn Pro Gln 
    930                 935                 940                 


Gly Pro Pro Tyr Ser Met Gly Gly Thr Met Ala Asn Asn Ser Ala Gly 
945                 950                 955                 960 


Met Ala Ala Ser Pro Glu Met Met Gly Leu Gly Asp Val Lys Leu Thr 
                965                 970                 975     


Pro Ala Thr Lys Met Asn Asn Lys Ala Asp Gly Thr Pro Lys Thr Glu 
            980                 985                 990         


Ser Lys Ser Lys Lys Ser Ser Ser  Ser Thr Thr Thr Asn  Glu Lys Ile 
        995                 1000                 1005             


Thr Lys  Leu Tyr Glu Leu Gly  Gly Glu Pro Glu Arg  Lys Met Trp 
    1010                 1015                 1020             


Val Asp  Arg Tyr Leu Ala Phe  Thr Glu Glu Lys Ala  Met Gly Met 
    1025                 1030                 1035             


Thr Asn  Leu Pro Ala Val Gly  Arg Lys Pro Leu Asp  Leu Tyr Arg 
    1040                 1045                 1050             


Leu Tyr  Val Ser Val Lys Glu  Ile Gly Gly Leu Thr  Gln Val Asn 
    1055                 1060                 1065             


Lys Asn  Lys Lys Trp Arg Glu  Leu Ala Thr Asn Leu  Asn Val Gly 
    1070                 1075                 1080             


Thr Ser  Ser Ser Ala Ala Ser  Ser Leu Lys Lys Gln  Tyr Ile Gln 
    1085                 1090                 1095             


Cys Leu  Tyr Ala Phe Glu Cys  Lys Ile Glu Arg Gly  Glu Asp Pro 
    1100                 1105                 1110             


Pro Pro  Asp Ile Phe Ala Ala  Ala Asp Ser Lys Lys  Ser Gln Pro 
    1115                 1120                 1125             


Lys Ile  Gln Pro Pro Ser Pro  Ala Gly Ser Gly Ser  Met Gln Gly 
    1130                 1135                 1140             


Pro Gln  Thr Pro Gln Ser Thr  Ser Ser Ser Met Ala  Glu Gly Gly 
    1145                 1150                 1155             


Asp Leu  Lys Pro Pro Thr Pro  Ala Ser Thr Pro His  Ser Gln Ile 
    1160                 1165                 1170             


Pro Pro  Leu Pro Gly Met Ser  Arg Ser Asn Ser Val  Gly Ile Gln 
    1175                 1180                 1185             


Asp Ala  Phe Asn Asp Gly Ser  Asp Ser Thr Phe Gln  Lys Arg Asn 
    1190                 1195                 1200             


Ser Met  Thr Pro Asn Pro Gly  Tyr Gln Pro Ser Met  Asn Thr Ser 
    1205                 1210                 1215             


Asp Met  Met Gly Arg Met Ser  Tyr Glu Pro Asn Lys  Asp Pro Tyr 
    1220                 1225                 1230             


Gly Ser  Met Arg Lys Ala Pro  Gly Ser Asp Pro Phe  Met Ser Ser 
    1235                 1240                 1245             


Gly Gln  Gly Pro Asn Gly Gly  Met Gly Asp Pro Tyr  Ser Arg Ala 
    1250                 1255                 1260             


Ala Gly  Pro Gly Leu Gly Asn  Val Ala Met Gly Pro  Arg Gln His 
    1265                 1270                 1275             


Tyr Pro  Tyr Gly Gly Pro Tyr  Asp Arg Val Arg Thr  Glu Pro Gly 
    1280                 1285                 1290             


Ile Gly  Pro Glu Gly Asn Met  Ser Thr Gly Ala Pro  Gln Pro Asn 
    1295                 1300                 1305             


Leu Met  Pro Ser Asn Pro Asp  Ser Gly Met Tyr Ser  Pro Ser Arg 
    1310                 1315                 1320             


Tyr Pro  Pro Gln Gln Gln Gln  Gln Gln Gln Gln Arg  His Asp Ser 
    1325                 1330                 1335             


Tyr Gly  Asn Gln Phe Ser Thr  Gln Gly Thr Pro Ser  Gly Ser Pro 
    1340                 1345                 1350             


Phe Pro  Ser Gln Gln Thr Thr  Met Tyr Gln Gln Gln  Gln Gln Asn 
    1355                 1360                 1365             


Tyr Lys  Arg Pro Met Asp Gly  Thr Tyr Gly Pro Pro  Ala Lys Arg 
    1370                 1375                 1380             


His Glu  Gly Glu Met Tyr Ser  Val Pro Tyr Ser Thr  Gly Gln Gly 
    1385                 1390                 1395             


Gln Pro  Gln Gln Gln Gln Leu  Pro Pro Ala Gln Pro  Gln Pro Ala 
    1400                 1405                 1410             


Ser Gln  Gln Gln Ala Ala Gln  Pro Ser Pro Gln Gln  Asp Val Tyr 
    1415                 1420                 1425             


Asn Gln  Tyr Gly Asn Ala Tyr  Pro Ala Thr Ala Thr  Ala Ala Thr 
    1430                 1435                 1440             


Glu Arg  Arg Pro Ala Gly Gly  Pro Gln Asn Gln Phe  Pro Phe Gln 
    1445                 1450                 1455             


Phe Gly  Arg Asp Arg Val Ser  Ala Pro Pro Gly Thr  Asn Ala Gln 
    1460                 1465                 1470             


Gln Asn  Met Pro Pro Gln Met  Met Gly Gly Pro Ile  Gln Ala Ser 
    1475                 1480                 1485             


Ala Glu  Val Ala Gln Gln Gly  Thr Met Trp Gln Gly  Arg Asn Asp 
    1490                 1495                 1500             


Met Thr  Tyr Asn Tyr Ala Asn  Arg Gln Ser Thr Gly  Ser Ala Pro 
    1505                 1510                 1515             


Gln Gly  Pro Ala Tyr His Gly  Val Asn Arg Thr Asp  Glu Met Leu 
    1520                 1525                 1530             


His Thr  Asp Gln Arg Ala Asn  His Glu Gly Ser Trp  Pro Ser His 
    1535                 1540                 1545             


Gly Thr  Arg Gln Pro Pro Tyr  Gly Pro Ser Ala Pro  Val Pro Pro 
    1550                 1555                 1560             


Met Thr  Arg Pro Pro Pro Ser  Asn Tyr Gln Pro Pro  Pro Ser Met 
    1565                 1570                 1575             


Gln Asn  His Ile Pro Gln Val  Ser Ser Pro Ala Pro  Leu Pro Arg 
    1580                 1585                 1590             


Pro Met  Glu Asn Arg Thr Ser  Pro Ser Lys Ser Pro  Phe Leu His 
    1595                 1600                 1605             


Ser Gly  Met Lys Met Gln Lys  Ala Gly Pro Pro Val  Pro Ala Ser 
    1610                 1615                 1620             


His Ile  Ala Pro Ala Pro Val  Gln Pro Pro Met Ile  Arg Arg Asp 
    1625                 1630                 1635             


Ile Thr  Phe Pro Pro Gly Ser  Val Glu Ala Thr Gln  Pro Val Leu 
    1640                 1645                 1650             


Lys Gln  Arg Arg Arg Leu Thr  Met Lys Asp Ile Gly  Thr Pro Glu 
    1655                 1660                 1665             


Ala Trp  Arg Val Met Met Ser  Leu Lys Ser Gly Leu  Leu Ala Glu 
    1670                 1675                 1680             


Ser Thr  Trp Ala Leu Asp Thr  Ile Asn Ile Leu Leu  Tyr Asp Asp 
    1685                 1690                 1695             


Asn Ser  Ile Met Thr Phe Asn  Leu Ser Gln Leu Pro  Gly Leu Leu 
    1700                 1705                 1710             


Glu Leu  Leu Val Glu Tyr Phe  Arg Arg Cys Leu Ile  Glu Ile Phe 
    1715                 1720                 1725             


Gly Ile  Leu Lys Glu Tyr Glu  Val Gly Asp Pro Gly  Gln Arg Thr 
    1730                 1735                 1740             


Leu Leu  Asp Pro Gly Arg Phe  Ser Lys Val Ser Ser  Pro Ala Pro 
    1745                 1750                 1755             


Met Glu  Gly Gly Glu Glu Glu  Glu Glu Leu Leu Gly  Pro Lys Leu 
    1760                 1765                 1770             


Glu Glu  Glu Glu Glu Glu Glu  Val Val Glu Asn Asp  Glu Glu Ile 
    1775                 1780                 1785             


Ala Phe  Ser Gly Lys Asp Lys  Pro Ala Ser Glu Asn  Ser Glu Glu 
    1790                 1795                 1800             


Lys Leu  Ile Ser Lys Phe Asp  Lys Leu Pro Val Lys  Ile Val Gln 
    1805                 1810                 1815             


Lys Asn  Asp Pro Phe Val Val  Asp Cys Ser Asp Lys  Leu Gly Arg 
    1820                 1825                 1830             


Val Gln  Glu Phe Asp Ser Gly  Leu Leu His Trp Arg  Ile Gly Gly 
    1835                 1840                 1845             


Gly Asp  Thr Thr Glu His Ile  Gln Thr His Phe Glu  Ser Lys Thr 
    1850                 1855                 1860             


Glu Leu  Leu Pro Ser Arg Pro  His Ala Pro Cys Pro  Pro Ala Pro 
    1865                 1870                 1875             


Arg Lys  His Val Thr Thr Ala  Glu Gly Thr Pro Gly  Thr Thr Asp 
    1880                 1885                 1890             


Gln Glu  Gly Pro Pro Pro Asp  Gly Pro Pro Glu Lys  Arg Ile Thr 
    1895                 1900                 1905             


Ala Thr  Met Asp Asp Met Leu  Ser Thr Arg Ser Ser  Thr Leu Thr 
    1910                 1915                 1920             


Glu Asp  Gly Ala Lys Ser Ser  Glu Ala Ile Lys Glu  Ser Ser Lys 
    1925                 1930                 1935             


Phe Pro  Phe Gly Ile Ser Pro  Ala Gln Ser His Arg  Asn Ile Lys 
    1940                 1945                 1950             


Ile Leu  Glu Asp Glu Pro His  Ser Lys Asp Glu Thr  Pro Leu Cys 
    1955                 1960                 1965             


Thr Leu  Leu Asp Trp Gln Asp  Ser Leu Ala Lys Arg  Cys Val Cys 
    1970                 1975                 1980             


Val Ser  Asn Thr Ile Arg Ser  Leu Ser Phe Val Pro  Gly Asn Asp 
    1985                 1990                 1995             


Phe Glu  Met Ser Lys His Pro  Gly Leu Leu Leu Ile  Leu Gly Lys 
    2000                 2005                 2010             


Leu Ile  Leu Leu His His Lys  His Pro Glu Arg Lys  Gln Ala Pro 
    2015                 2020                 2025             


Leu Thr  Tyr Glu Lys Glu Glu  Glu Gln Asp Gln Gly  Val Ser Cys 
    2030                 2035                 2040             


Asn Lys  Val Glu Trp Trp Trp  Asp Cys Leu Glu Met  Leu Arg Glu 
    2045                 2050                 2055             


Asn Thr  Leu Val Thr Leu Ala  Asn Ile Ser Gly Gln  Leu Asp Leu 
    2060                 2065                 2070             


Ser Pro  Tyr Pro Glu Ser Ile  Cys Leu Pro Val Leu  Asp Gly Leu 
    2075                 2080                 2085             


Leu His  Trp Ala Val Cys Pro  Ser Ala Glu Ala Gln  Asp Pro Phe 
    2090                 2095                 2100             


Ser Thr  Leu Gly Pro Asn Ala  Val Leu Ser Pro Gln  Arg Leu Val 
    2105                 2110                 2115             


Leu Glu  Thr Leu Ser Lys Leu  Ser Ile Gln Asp Asn  Asn Val Asp 
    2120                 2125                 2130             


Leu Ile  Leu Ala Thr Pro Pro  Phe Ser Arg Leu Glu  Lys Leu Tyr 
    2135                 2140                 2145             


Ser Thr  Met Val Arg Phe Leu  Ser Asp Arg Lys Asn  Pro Val Cys 
    2150                 2155                 2160             


Arg Glu  Met Ala Val Val Leu  Leu Ala Asn Leu Ala  Gln Gly Asp 
    2165                 2170                 2175             


Ser Leu  Ala Ala Arg Ala Ile  Ala Val Gln Lys Gly  Ser Ile Gly 
    2180                 2185                 2190             


Asn Leu  Leu Gly Phe Leu Glu  Asp Ser Leu Ala Ala  Thr Gln Phe 
    2195                 2200                 2205             


Gln Gln  Ser Gln Ala Ser Leu  Leu His Met Gln Asn  Pro Pro Phe 
    2210                 2215                 2220             


Glu Pro  Thr Ser Val Asp Met  Met Arg Arg Ala Ala  Arg Ala Leu 
    2225                 2230                 2235             


Leu Ala  Leu Ala Lys Val Asp  Glu Asn His Ser Glu  Phe Thr Leu 
    2240                 2245                 2250             


Tyr Glu  Ser Arg Leu Leu Asp  Ile Ser Val Ser Pro  Leu Met Asn 
    2255                 2260                 2265             


Ser Leu  Val Ser Gln Val Ile  Cys Asp Val Leu Phe  Leu Ile Gly 
    2270                 2275                 2280             


Gln Ser  
    2285 


<210>  183
<211>  521
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UnitProt / O00629
<309>  1998-01-27
<313>  (1)..(521)

<400>  183

Met Ala Asp Asn Glu Lys Leu Asp Asn Gln Arg Leu Lys Asn Phe Lys 
1               5                   10                  15      


Asn Lys Gly Arg Asp Leu Glu Thr Met Arg Arg Gln Arg Asn Glu Val 
            20                  25                  30          


Val Val Glu Leu Arg Lys Asn Lys Arg Asp Glu His Leu Leu Lys Arg 
        35                  40                  45              


Arg Asn Val Pro His Glu Asp Ile Cys Glu Asp Ser Asp Ile Asp Gly 
    50                  55                  60                  


Asp Tyr Arg Val Gln Asn Thr Ser Leu Glu Ala Ile Val Gln Asn Ala 
65                  70                  75                  80  


Ser Ser Asp Asn Gln Gly Ile Gln Leu Ser Ala Val Gln Ala Ala Arg 
                85                  90                  95      


Lys Leu Leu Ser Ser Asp Arg Asn Pro Pro Ile Asp Asp Leu Ile Lys 
            100                 105                 110         


Ser Gly Ile Leu Pro Ile Leu Val His Cys Leu Glu Arg Asp Asp Asn 
        115                 120                 125             


Pro Ser Leu Gln Phe Glu Ala Ala Trp Ala Leu Thr Asn Ile Ala Ser 
    130                 135                 140                 


Gly Thr Ser Glu Gln Thr Gln Ala Val Val Gln Ser Asn Ala Val Pro 
145                 150                 155                 160 


Leu Phe Leu Arg Leu Leu His Ser Pro His Gln Asn Val Cys Glu Gln 
                165                 170                 175     


Ala Val Trp Ala Leu Gly Asn Ile Ile Gly Asp Gly Pro Gln Cys Arg 
            180                 185                 190         


Asp Tyr Val Ile Ser Leu Gly Val Val Lys Pro Leu Leu Ser Phe Ile 
        195                 200                 205             


Ser Pro Ser Ile Pro Ile Thr Phe Leu Arg Asn Val Thr Trp Val Met 
    210                 215                 220                 


Val Asn Leu Cys Arg His Lys Asp Pro Pro Pro Pro Met Glu Thr Ile 
225                 230                 235                 240 


Gln Glu Ile Leu Pro Ala Leu Cys Val Leu Ile His His Thr Asp Val 
                245                 250                 255     


Asn Ile Leu Val Asp Thr Val Trp Ala Leu Ser Tyr Leu Thr Asp Ala 
            260                 265                 270         


Gly Asn Glu Gln Ile Gln Met Val Ile Asp Ser Gly Ile Val Pro His 
        275                 280                 285             


Leu Val Pro Leu Leu Ser His Gln Glu Val Lys Val Gln Thr Ala Ala 
    290                 295                 300                 


Leu Arg Ala Val Gly Asn Ile Val Thr Gly Thr Asp Glu Gln Thr Gln 
305                 310                 315                 320 


Val Val Leu Asn Cys Asp Ala Leu Ser His Phe Pro Ala Leu Leu Thr 
                325                 330                 335     


His Pro Lys Glu Lys Ile Asn Lys Glu Ala Val Trp Phe Leu Ser Asn 
            340                 345                 350         


Ile Thr Ala Gly Asn Gln Gln Gln Val Gln Ala Val Ile Asp Ala Asn 
        355                 360                 365             


Leu Val Pro Met Ile Ile His Leu Leu Asp Lys Gly Asp Phe Gly Thr 
    370                 375                 380                 


Gln Lys Glu Ala Ala Trp Ala Ile Ser Asn Leu Thr Ile Ser Gly Arg 
385                 390                 395                 400 


Lys Asp Gln Val Ala Tyr Leu Ile Gln Gln Asn Val Ile Pro Pro Phe 
                405                 410                 415     


Cys Asn Leu Leu Thr Val Lys Asp Ala Gln Val Val Gln Val Val Leu 
            420                 425                 430         


Asp Gly Leu Ser Asn Ile Leu Lys Met Ala Glu Asp Glu Ala Glu Thr 
        435                 440                 445             


Ile Gly Asn Leu Ile Glu Glu Cys Gly Gly Leu Glu Lys Ile Glu Gln 
    450                 455                 460                 


Leu Gln Asn His Glu Asn Glu Asp Ile Tyr Lys Leu Ala Tyr Glu Ile 
465                 470                 475                 480 


Ile Asp Gln Phe Phe Ser Ser Asp Asp Ile Asp Glu Asp Pro Ser Leu 
                485                 490                 495     


Val Pro Glu Ala Ile Gln Gly Gly Thr Phe Gly Phe Asn Ser Ser Ala 
            500                 505                 510         


Asn Val Pro Thr Glu Gly Phe Gln Phe 
        515                 520     


<210>  184
<211>  686
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q96MM6
<309>  2016-09-07
<313>  (1)..(686)

<400>  184

Met Leu Ala Val Pro Glu Met Gly Leu Gln Gly Leu Tyr Ile Gly Ser 
1               5                   10                  15      


Ser Pro Glu Arg Ser Pro Val Pro Ser Pro Pro Gly Ser Pro Arg Thr 
            20                  25                  30          


Gln Glu Ser Cys Gly Ile Ala Pro Leu Thr Pro Ser Gln Ser Pro Lys 
        35                  40                  45              


Pro Glu Val Arg Ala Pro Gln Gln Ala Ser Phe Ser Val Val Val Ala 
    50                  55                  60                  


Ile Asp Phe Gly Thr Thr Ser Ser Gly Tyr Ala Phe Ser Phe Ala Ser 
65                  70                  75                  80  


Asp Pro Glu Ala Ile His Met Met Arg Lys Trp Glu Gly Gly Asp Pro 
                85                  90                  95      


Gly Val Ala His Gln Lys Thr Pro Thr Cys Leu Leu Leu Thr Pro Glu 
            100                 105                 110         


Gly Ala Phe His Ser Phe Gly Tyr Thr Ala Arg Asp Tyr Tyr His Asp 
        115                 120                 125             


Leu Asp Pro Glu Glu Ala Arg Asp Trp Leu Tyr Phe Glu Lys Phe Lys 
    130                 135                 140                 


Met Lys Ile His Ser Ala Thr Asp Leu Thr Leu Lys Thr Gln Leu Glu 
145                 150                 155                 160 


Ala Val Asn Gly Lys Thr Met Pro Ala Leu Glu Val Phe Ala His Ala 
                165                 170                 175     


Leu Arg Phe Phe Arg Glu His Ala Leu Gln Glu Leu Arg Glu Gln Ser 
            180                 185                 190         


Pro Ser Leu Pro Glu Lys Asp Thr Val Arg Trp Val Leu Thr Val Pro 
        195                 200                 205             


Ala Ile Trp Lys Gln Pro Ala Lys Gln Phe Met Arg Glu Ala Ala Tyr 
    210                 215                 220                 


Leu Ala Gly Leu Val Ser Arg Glu Asn Ala Glu Gln Leu Leu Ile Ala 
225                 230                 235                 240 


Leu Glu Pro Glu Ala Ala Ser Val Tyr Cys Arg Lys Leu Arg Leu His 
                245                 250                 255     


Gln Leu Leu Asp Leu Ser Gly Arg Ala Pro Gly Gly Gly Arg Leu Gly 
            260                 265                 270         


Glu Arg Arg Ser Ile Asp Ser Ser Phe Arg Gln Ala Arg Glu Gln Leu 
        275                 280                 285             


Arg Arg Ser Arg His Ser Arg Thr Phe Leu Val Glu Ser Gly Val Gly 
    290                 295                 300                 


Glu Leu Trp Ala Glu Met Gln Ala Gly Asp Arg Tyr Val Val Ala Asp 
305                 310                 315                 320 


Cys Gly Gly Gly Thr Val Asp Leu Thr Val His Gln Leu Glu Gln Pro 
                325                 330                 335     


His Gly Thr Leu Lys Glu Leu Tyr Lys Ala Ser Gly Gly Pro Tyr Gly 
            340                 345                 350         


Ala Val Gly Val Asp Leu Ala Phe Glu Gln Leu Leu Cys Arg Ile Phe 
        355                 360                 365             


Gly Glu Asp Phe Ile Ala Thr Phe Lys Arg Gln Arg Pro Ala Ala Trp 
    370                 375                 380                 


Val Asp Leu Thr Ile Ala Phe Glu Ala Arg Lys Arg Thr Ala Gly Pro 
385                 390                 395                 400 


His Arg Ala Gly Ala Leu Asn Ile Ser Leu Pro Phe Ser Phe Ile Asp 
                405                 410                 415     


Phe Tyr Arg Lys Gln Arg Gly His Asn Val Glu Thr Ala Leu Arg Arg 
            420                 425                 430         


Ser Ser Val Asn Phe Val Lys Trp Ser Ser Gln Gly Met Leu Arg Met 
        435                 440                 445             


Ser Cys Glu Ala Met Asn Glu Leu Phe Gln Pro Thr Val Ser Gly Ile 
    450                 455                 460                 


Ile Gln His Ile Glu Ala Leu Leu Ala Arg Pro Glu Val Gln Gly Val 
465                 470                 475                 480 


Lys Leu Leu Phe Leu Val Gly Gly Phe Ala Glu Ser Ala Val Leu Gln 
                485                 490                 495     


His Ala Val Gln Ala Ala Leu Gly Ala Arg Gly Leu Arg Val Val Val 
            500                 505                 510         


Pro His Asp Val Gly Leu Thr Ile Leu Lys Gly Ala Val Leu Phe Gly 
        515                 520                 525             


Gln Ala Pro Gly Val Val Arg Val Arg Arg Ser Pro Leu Thr Tyr Gly 
    530                 535                 540                 


Val Gly Val Leu Asn Arg Phe Val Pro Gly Arg His Pro Pro Glu Lys 
545                 550                 555                 560 


Leu Leu Val Arg Asp Gly Arg Arg Trp Cys Thr Asp Val Phe Glu Arg 
                565                 570                 575     


Phe Val Ala Ala Glu Gln Ser Val Ala Leu Gly Glu Glu Val Arg Arg 
            580                 585                 590         


Ser Tyr Cys Pro Ala Arg Pro Gly Gln Arg Arg Val Leu Ile Asn Leu 
        595                 600                 605             


Tyr Cys Cys Ala Ala Glu Asp Ala Arg Phe Ile Thr Asp Pro Gly Val 
    610                 615                 620                 


Arg Lys Cys Gly Ala Leu Ser Leu Glu Leu Glu Pro Ala Asp Cys Gly 
625                 630                 635                 640 


Gln Asp Thr Ala Gly Ala Pro Pro Gly Arg Arg Glu Ile Arg Ala Ala 
                645                 650                 655     


Met Gln Phe Gly Asp Thr Glu Ile Lys Val Thr Ala Val Asp Val Ser 
            660                 665                 670         


Thr Asn Arg Ser Val Arg Ala Ser Ile Asp Phe Leu Ser Asn 
        675                 680                 685     


<210>  185
<211>  165
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P30050
<309>  1993-05-13
<313>  (1)..(165)

<400>  185

Met Pro Pro Lys Phe Asp Pro Asn Glu Ile Lys Val Val Tyr Leu Arg 
1               5                   10                  15      


Cys Thr Gly Gly Glu Val Gly Ala Thr Ser Ala Leu Ala Pro Lys Ile 
            20                  25                  30          


Gly Pro Leu Gly Leu Ser Pro Lys Lys Val Gly Asp Asp Ile Ala Lys 
        35                  40                  45              


Ala Thr Gly Asp Trp Lys Gly Leu Arg Ile Thr Val Lys Leu Thr Ile 
    50                  55                  60                  


Gln Asn Arg Gln Ala Gln Ile Glu Val Val Pro Ser Ala Ser Ala Leu 
65                  70                  75                  80  


Ile Ile Lys Ala Leu Lys Glu Pro Pro Arg Asp Arg Lys Lys Gln Lys 
                85                  90                  95      


Asn Ile Lys His Ser Gly Asn Ile Thr Phe Asp Glu Ile Val Asn Ile 
            100                 105                 110         


Ala Arg Gln Met Arg His Arg Ser Leu Ala Arg Glu Leu Ser Gly Thr 
        115                 120                 125             


Ile Lys Glu Ile Leu Gly Thr Ala Gln Ser Val Gly Cys Asn Val Asp 
    130                 135                 140                 


Gly Arg His Pro His Asp Ile Ile Asp Asp Ile Asn Ser Gly Ala Val 
145                 150                 155                 160 


Glu Cys Pro Ala Ser 
                165 


<210>  186
<211>  633
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O43390
<309>  2001-01-15
<313>  (1)..(633)

<400>  186

Met Ala Asn Gln Val Asn Gly Asn Ala Val Gln Leu Lys Glu Glu Glu 
1               5                   10                  15      


Glu Pro Met Asp Thr Ser Ser Val Thr His Thr Glu His Tyr Lys Thr 
            20                  25                  30          


Leu Ile Glu Ala Gly Leu Pro Gln Lys Val Ala Glu Arg Leu Asp Glu 
        35                  40                  45              


Ile Phe Gln Thr Gly Leu Val Ala Tyr Val Asp Leu Asp Glu Arg Ala 
    50                  55                  60                  


Ile Asp Ala Leu Arg Glu Phe Asn Glu Glu Gly Ala Leu Ser Val Leu 
65                  70                  75                  80  


Gln Gln Phe Lys Glu Ser Asp Leu Ser His Val Gln Asn Lys Ser Ala 
                85                  90                  95      


Phe Leu Cys Gly Val Met Lys Thr Tyr Arg Gln Arg Glu Lys Gln Gly 
            100                 105                 110         


Ser Lys Val Gln Glu Ser Thr Lys Gly Pro Asp Glu Ala Lys Ile Lys 
        115                 120                 125             


Ala Leu Leu Glu Arg Thr Gly Tyr Thr Leu Asp Val Thr Thr Gly Gln 
    130                 135                 140                 


Arg Lys Tyr Gly Gly Pro Pro Pro Asp Ser Val Tyr Ser Gly Val Gln 
145                 150                 155                 160 


Pro Gly Ile Gly Thr Glu Val Phe Val Gly Lys Ile Pro Arg Asp Leu 
                165                 170                 175     


Tyr Glu Asp Glu Leu Val Pro Leu Phe Glu Lys Ala Gly Pro Ile Trp 
            180                 185                 190         


Asp Leu Arg Leu Met Met Asp Pro Leu Ser Gly Gln Asn Arg Gly Tyr 
        195                 200                 205             


Ala Phe Ile Thr Phe Cys Gly Lys Glu Ala Ala Gln Glu Ala Val Lys 
    210                 215                 220                 


Leu Cys Asp Ser Tyr Glu Ile Arg Pro Gly Lys His Leu Gly Val Cys 
225                 230                 235                 240 


Ile Ser Val Ala Asn Asn Arg Leu Phe Val Gly Ser Ile Pro Lys Asn 
                245                 250                 255     


Lys Thr Lys Glu Asn Ile Leu Glu Glu Phe Ser Lys Val Thr Glu Gly 
            260                 265                 270         


Leu Val Asp Val Ile Leu Tyr His Gln Pro Asp Asp Lys Lys Lys Asn 
        275                 280                 285             


Arg Gly Phe Cys Phe Leu Glu Tyr Glu Asp His Lys Ser Ala Ala Gln 
    290                 295                 300                 


Ala Arg Arg Arg Leu Met Ser Gly Lys Val Lys Val Trp Gly Asn Val 
305                 310                 315                 320 


Val Thr Val Glu Trp Ala Asp Pro Val Glu Glu Pro Asp Pro Glu Val 
                325                 330                 335     


Met Ala Lys Val Lys Val Leu Phe Val Arg Asn Leu Ala Thr Thr Val 
            340                 345                 350         


Thr Glu Glu Ile Leu Glu Lys Ser Phe Ser Glu Phe Gly Lys Leu Glu 
        355                 360                 365             


Arg Val Lys Lys Leu Lys Asp Tyr Ala Phe Val His Phe Glu Asp Arg 
    370                 375                 380                 


Gly Ala Ala Val Lys Ala Met Asp Glu Met Asn Gly Lys Glu Ile Glu 
385                 390                 395                 400 


Gly Glu Glu Ile Glu Ile Val Leu Ala Lys Pro Pro Asp Lys Lys Arg 
                405                 410                 415     


Lys Glu Arg Gln Ala Ala Arg Gln Ala Ser Arg Ser Thr Ala Tyr Glu 
            420                 425                 430         


Asp Tyr Tyr Tyr His Pro Pro Pro Arg Met Pro Pro Pro Ile Arg Gly 
        435                 440                 445             


Arg Gly Arg Gly Gly Gly Arg Gly Gly Tyr Gly Tyr Pro Pro Asp Tyr 
    450                 455                 460                 


Tyr Gly Tyr Glu Asp Tyr Tyr Asp Asp Tyr Tyr Gly Tyr Asp Tyr His 
465                 470                 475                 480 


Asp Tyr Arg Gly Gly Tyr Glu Asp Pro Tyr Tyr Gly Tyr Asp Asp Gly 
                485                 490                 495     


Tyr Ala Val Arg Gly Arg Gly Gly Gly Arg Gly Gly Arg Gly Ala Pro 
            500                 505                 510         


Pro Pro Pro Arg Gly Arg Gly Ala Pro Pro Pro Arg Gly Arg Ala Gly 
        515                 520                 525             


Tyr Ser Gln Arg Gly Ala Pro Leu Gly Pro Pro Arg Gly Ser Arg Gly 
    530                 535                 540                 


Gly Arg Gly Gly Pro Ala Gln Gln Gln Arg Gly Arg Gly Ser Arg Gly 
545                 550                 555                 560 


Ser Arg Gly Asn Arg Gly Gly Asn Val Gly Gly Lys Arg Lys Ala Asp 
                565                 570                 575     


Gly Tyr Asn Gln Pro Asp Ser Lys Arg Arg Gln Thr Asn Asn Gln Gln 
            580                 585                 590         


Asn Trp Gly Ser Gln Pro Ile Ala Gln Gln Pro Leu Gln Gln Gly Gly 
        595                 600                 605             


Asp Tyr Ser Gly Asn Tyr Gly Tyr Asn Asn Asp Asn Gln Glu Phe Tyr 
    610                 615                 620                 


Gln Asp Thr Tyr Gly Gln Gln Trp Lys 
625                 630             


<210>  187
<211>  176
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q02543
<309>  2016-09-07
<313>  (1)..(176)

<400>  187

Met Lys Ala Ser Gly Thr Leu Arg Glu Tyr Lys Val Val Gly Arg Cys 
1               5                   10                  15      


Leu Pro Thr Pro Lys Cys His Thr Pro Pro Leu Tyr Arg Met Arg Ile 
            20                  25                  30          


Phe Ala Pro Asn His Val Val Ala Lys Ser Arg Phe Trp Tyr Phe Val 
        35                  40                  45              


Ser Gln Leu Lys Lys Met Lys Lys Ser Ser Gly Glu Ile Val Tyr Cys 
    50                  55                  60                  


Gly Gln Val Phe Glu Lys Ser Pro Leu Arg Val Lys Asn Phe Gly Ile 
65                  70                  75                  80  


Trp Leu Arg Tyr Asp Ser Arg Ser Gly Thr His Asn Met Tyr Arg Glu 
                85                  90                  95      


Tyr Arg Asp Leu Thr Thr Ala Gly Ala Val Thr Gln Cys Tyr Arg Asp 
            100                 105                 110         


Met Gly Ala Arg His Arg Ala Arg Ala His Ser Ile Gln Ile Met Lys 
        115                 120                 125             


Val Glu Glu Ile Ala Ala Ser Lys Cys Arg Arg Pro Ala Val Lys Gln 
    130                 135                 140                 


Phe His Asp Ser Lys Ile Lys Phe Pro Leu Pro His Arg Val Leu Arg 
145                 150                 155                 160 


Arg Gln His Lys Pro Arg Phe Thr Thr Lys Arg Pro Asn Thr Phe Phe 
                165                 170                 175     


<210>  188
<211>  333
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P13804
<309>  1993-04-23
<313>  (1)..(333)

<400>  188

Met Phe Arg Ala Ala Ala Pro Gly Gln Leu Arg Arg Ala Ala Ser Leu 
1               5                   10                  15      


Leu Arg Phe Gln Ser Thr Leu Val Ile Ala Glu His Ala Asn Asp Ser 
            20                  25                  30          


Leu Ala Pro Ile Thr Leu Asn Thr Ile Thr Ala Ala Thr Arg Leu Gly 
        35                  40                  45              


Gly Glu Val Ser Cys Leu Val Ala Gly Thr Lys Cys Asp Lys Val Ala 
    50                  55                  60                  


Gln Asp Leu Cys Lys Val Ala Gly Ile Ala Lys Val Leu Val Ala Gln 
65                  70                  75                  80  


His Asp Val Tyr Lys Gly Leu Leu Pro Glu Glu Leu Thr Pro Leu Ile 
                85                  90                  95      


Leu Ala Thr Gln Lys Gln Phe Asn Tyr Thr His Ile Cys Ala Gly Ala 
            100                 105                 110         


Ser Ala Phe Gly Lys Asn Leu Leu Pro Arg Val Ala Ala Lys Leu Glu 
        115                 120                 125             


Val Ala Pro Ile Ser Asp Ile Ile Ala Ile Lys Ser Pro Asp Thr Phe 
    130                 135                 140                 


Val Arg Thr Ile Tyr Ala Gly Asn Ala Leu Cys Thr Val Lys Cys Asp 
145                 150                 155                 160 


Glu Lys Val Lys Val Phe Ser Val Arg Gly Thr Ser Phe Asp Ala Ala 
                165                 170                 175     


Ala Thr Ser Gly Gly Ser Ala Ser Ser Glu Lys Ala Ser Ser Thr Ser 
            180                 185                 190         


Pro Val Glu Ile Ser Glu Trp Leu Asp Gln Lys Leu Thr Lys Ser Asp 
        195                 200                 205             


Arg Pro Glu Leu Thr Gly Ala Lys Val Val Val Ser Gly Gly Arg Gly 
    210                 215                 220                 


Leu Lys Ser Gly Glu Asn Phe Lys Leu Leu Tyr Asp Leu Ala Asp Gln 
225                 230                 235                 240 


Leu His Ala Ala Val Gly Ala Ser Arg Ala Ala Val Asp Ala Gly Phe 
                245                 250                 255     


Val Pro Asn Asp Met Gln Val Gly Gln Thr Gly Lys Ile Val Ala Pro 
            260                 265                 270         


Glu Leu Tyr Ile Ala Val Gly Ile Ser Gly Ala Ile Gln His Leu Ala 
        275                 280                 285             


Gly Met Lys Asp Ser Lys Thr Ile Val Ala Ile Asn Lys Asp Pro Glu 
    290                 295                 300                 


Ala Pro Ile Phe Gln Val Ala Asp Tyr Gly Ile Val Ala Asp Leu Phe 
305                 310                 315                 320 


Lys Val Val Pro Glu Met Thr Glu Ile Leu Lys Lys Lys 
                325                 330             


<210>  189
<211>  503
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q8NC56
<309>  2016-09-07
<313>  (1)..(503)

<400>  189

Met Ala Gly Leu Ser Asp Leu Glu Leu Arg Arg Glu Leu Gln Ala Leu 
1               5                   10                  15      


Gly Phe Gln Pro Gly Pro Ile Thr Asp Thr Thr Arg Asp Val Tyr Arg 
            20                  25                  30          


Asn Lys Leu Arg Arg Leu Arg Gly Glu Ala Arg Leu Arg Asp Glu Glu 
        35                  40                  45              


Arg Leu Arg Glu Glu Ala Arg Pro Arg Gly Glu Glu Arg Leu Arg Glu 
    50                  55                  60                  


Glu Ala Arg Leu Arg Glu Asp Ala Pro Leu Arg Ala Arg Pro Ala Ala 
65                  70                  75                  80  


Ala Ser Pro Arg Ala Glu Pro Trp Leu Ser Gln Pro Ala Ser Gly Ser 
                85                  90                  95      


Ala Tyr Ala Thr Pro Gly Ala Tyr Gly Asp Ile Arg Pro Ser Ala Ala 
            100                 105                 110         


Ser Trp Val Gly Ser Arg Gly Leu Ala Tyr Pro Ala Arg Pro Ala Gln 
        115                 120                 125             


Leu Arg Arg Arg Ala Ser Val Arg Gly Ser Ser Glu Glu Asp Glu Asp 
    130                 135                 140                 


Ala Arg Thr Pro Asp Arg Ala Thr Gln Gly Pro Gly Leu Ala Ala Arg 
145                 150                 155                 160 


Arg Trp Trp Ala Ala Ser Pro Ala Pro Ala Arg Leu Pro Ser Ser Leu 
                165                 170                 175     


Leu Gly Pro Asp Pro Arg Pro Gly Leu Arg Ala Thr Arg Ala Gly Pro 
            180                 185                 190         


Ala Gly Ala Ala Arg Ala Arg Pro Glu Val Gly Arg Arg Leu Glu Arg 
        195                 200                 205             


Trp Leu Ser Arg Leu Leu Leu Trp Ala Ser Leu Gly Leu Leu Leu Val 
    210                 215                 220                 


Phe Leu Gly Ile Leu Trp Val Lys Met Gly Lys Pro Ser Ala Pro Gln 
225                 230                 235                 240 


Glu Ala Glu Asp Asn Met Lys Leu Leu Pro Val Asp Cys Glu Arg Lys 
                245                 250                 255     


Thr Asp Glu Phe Cys Gln Ala Lys Gln Lys Ala Ala Leu Leu Glu Leu 
            260                 265                 270         


Leu His Glu Leu Tyr Asn Phe Leu Ala Ile Gln Ala Gly Asn Phe Glu 
        275                 280                 285             


Cys Gly Asn Pro Glu Asn Leu Lys Ser Lys Cys Ile Pro Val Met Glu 
    290                 295                 300                 


Ala Gln Glu Tyr Ile Ala Asn Val Thr Ser Ser Ser Ser Ala Lys Phe 
305                 310                 315                 320 


Glu Ala Ala Leu Thr Trp Ile Leu Ser Ser Asn Lys Asp Val Gly Ile 
                325                 330                 335     


Trp Leu Lys Gly Glu Asp Gln Ser Glu Leu Val Thr Thr Val Asp Lys 
            340                 345                 350         


Val Val Cys Leu Glu Ser Ala His Pro Arg Met Gly Val Gly Cys Arg 
        355                 360                 365             


Leu Ser Arg Ala Leu Leu Thr Ala Val Thr Asn Val Leu Ile Phe Phe 
    370                 375                 380                 


Trp Cys Leu Ala Phe Leu Trp Gly Leu Leu Ile Leu Leu Lys Tyr Arg 
385                 390                 395                 400 


Trp Arg Lys Leu Glu Glu Glu Glu Gln Ala Met Tyr Glu Met Val Lys 
                405                 410                 415     


Lys Ile Ile Asp Val Val Gln Asp His Tyr Val Asp Trp Glu Gln Asp 
            420                 425                 430         


Met Glu Arg Tyr Pro Tyr Val Gly Ile Leu His Val Arg Asp Ser Leu 
        435                 440                 445             


Ile Pro Pro Gln Ser Arg Arg Arg Met Lys Arg Val Trp Asp Arg Ala 
    450                 455                 460                 


Val Glu Phe Leu Ala Ser Asn Glu Ser Arg Ile Gln Thr Glu Ser His 
465                 470                 475                 480 


Arg Val Ala Gly Glu Asp Met Leu Val Trp Arg Trp Thr Lys Pro Ser 
                485                 490                 495     


Ser Phe Ser Asp Ser Glu Arg 
            500             


<210>  190
<211>  450
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q13509
<309>  2016-09-07
<313>  (1)..(450)

<400>  190

Met Arg Glu Ile Val His Ile Gln Ala Gly Gln Cys Gly Asn Gln Ile 
1               5                   10                  15      


Gly Ala Lys Phe Trp Glu Val Ile Ser Asp Glu His Gly Ile Asp Pro 
            20                  25                  30          


Ser Gly Asn Tyr Val Gly Asp Ser Asp Leu Gln Leu Glu Arg Ile Ser 
        35                  40                  45              


Val Tyr Tyr Asn Glu Ala Ser Ser His Lys Tyr Val Pro Arg Ala Ile 
    50                  55                  60                  


Leu Val Asp Leu Glu Pro Gly Thr Met Asp Ser Val Arg Ser Gly Ala 
65                  70                  75                  80  


Phe Gly His Leu Phe Arg Pro Asp Asn Phe Ile Phe Gly Gln Ser Gly 
                85                  90                  95      


Ala Gly Asn Asn Trp Ala Lys Gly His Tyr Thr Glu Gly Ala Glu Leu 
            100                 105                 110         


Val Asp Ser Val Leu Asp Val Val Arg Lys Glu Cys Glu Asn Cys Asp 
        115                 120                 125             


Cys Leu Gln Gly Phe Gln Leu Thr His Ser Leu Gly Gly Gly Thr Gly 
    130                 135                 140                 


Ser Gly Met Gly Thr Leu Leu Ile Ser Lys Val Arg Glu Glu Tyr Pro 
145                 150                 155                 160 


Asp Arg Ile Met Asn Thr Phe Ser Val Val Pro Ser Pro Lys Val Ser 
                165                 170                 175     


Asp Thr Val Val Glu Pro Tyr Asn Ala Thr Leu Ser Ile His Gln Leu 
            180                 185                 190         


Val Glu Asn Thr Asp Glu Thr Tyr Cys Ile Asp Asn Glu Ala Leu Tyr 
        195                 200                 205             


Asp Ile Cys Phe Arg Thr Leu Lys Leu Ala Thr Pro Thr Tyr Gly Asp 
    210                 215                 220                 


Leu Asn His Leu Val Ser Ala Thr Met Ser Gly Val Thr Thr Ser Leu 
225                 230                 235                 240 


Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg Lys Leu Ala Val Asn 
                245                 250                 255     


Met Val Pro Phe Pro Arg Leu His Phe Phe Met Pro Gly Phe Ala Pro 
            260                 265                 270         


Leu Thr Ala Arg Gly Ser Gln Gln Tyr Arg Ala Leu Thr Val Pro Glu 
        275                 280                 285             


Leu Thr Gln Gln Met Phe Asp Ala Lys Asn Met Met Ala Ala Cys Asp 
    290                 295                 300                 


Pro Arg His Gly Arg Tyr Leu Thr Val Ala Thr Val Phe Arg Gly Arg 
305                 310                 315                 320 


Met Ser Met Lys Glu Val Asp Glu Gln Met Leu Ala Ile Gln Ser Lys 
                325                 330                 335     


Asn Ser Ser Tyr Phe Val Glu Trp Ile Pro Asn Asn Val Lys Val Ala 
            340                 345                 350         


Val Cys Asp Ile Pro Pro Arg Gly Leu Lys Met Ser Ser Thr Phe Ile 
        355                 360                 365             


Gly Asn Ser Thr Ala Ile Gln Glu Leu Phe Lys Arg Ile Ser Glu Gln 
    370                 375                 380                 


Phe Thr Ala Met Phe Arg Arg Lys Ala Phe Leu His Trp Tyr Thr Gly 
385                 390                 395                 400 


Glu Gly Met Asp Glu Met Glu Phe Thr Glu Ala Glu Ser Asn Met Asn 
                405                 410                 415     


Asp Leu Val Ser Glu Tyr Gln Gln Tyr Gln Asp Ala Thr Ala Glu Glu 
            420                 425                 430         


Glu Gly Glu Met Tyr Glu Asp Asp Glu Glu Glu Ser Glu Ala Gln Gly 
        435                 440                 445             


Pro Lys 
    450 


<210>  191
<211>  692
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O43823
<309>  1999-09-17
<313>  (1)..(692)

<400>  191

Met Asp Gln Gly Tyr Gly Gly Tyr Gly Ala Trp Ser Ala Gly Pro Ala 
1               5                   10                  15      


Asn Thr Gln Gly Ala Tyr Gly Thr Gly Val Ala Ser Trp Gln Gly Tyr 
            20                  25                  30          


Glu Asn Tyr Asn Tyr Tyr Gly Ala Gln Asn Thr Ser Val Thr Thr Gly 
        35                  40                  45              


Ala Thr Tyr Ser Tyr Gly Pro Ala Ser Trp Glu Ala Ala Lys Ala Asn 
    50                  55                  60                  


Asp Gly Gly Leu Ala Ala Gly Ala Pro Ala Met His Met Ala Ser Tyr 
65                  70                  75                  80  


Gly Pro Glu Pro Cys Thr Asp Asn Ser Asp Ser Leu Ile Ala Lys Ile 
                85                  90                  95      


Asn Gln Arg Leu Asp Met Met Ser Lys Glu Gly Gly Arg Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Glu Gly Ile Gln Asp Arg Glu Ser Ser Phe Arg Phe 
        115                 120                 125             


Gln Pro Phe Glu Ser Tyr Asp Ser Arg Pro Cys Leu Pro Glu His Asn 
    130                 135                 140                 


Pro Tyr Arg Pro Ser Tyr Ser Tyr Asp Tyr Glu Phe Asp Leu Gly Ser 
145                 150                 155                 160 


Asp Arg Asn Gly Ser Phe Gly Gly Gln Tyr Ser Glu Cys Arg Asp Pro 
                165                 170                 175     


Ala Arg Glu Arg Gly Ser Leu Asp Gly Phe Met Arg Gly Arg Gly Gln 
            180                 185                 190         


Gly Arg Phe Gln Asp Arg Ser Asn Pro Gly Thr Phe Met Arg Ser Asp 
        195                 200                 205             


Pro Phe Val Pro Pro Ala Ala Ser Ser Glu Pro Leu Ser Thr Pro Trp 
    210                 215                 220                 


Asn Glu Leu Asn Tyr Val Gly Gly Arg Gly Leu Gly Gly Pro Ser Pro 
225                 230                 235                 240 


Ser Arg Pro Pro Pro Ser Leu Phe Ser Gln Ser Met Ala Pro Asp Tyr 
                245                 250                 255     


Gly Val Met Gly Met Gln Gly Ala Gly Gly Tyr Asp Ser Thr Met Pro 
            260                 265                 270         


Tyr Gly Cys Gly Arg Ser Gln Pro Arg Met Arg Asp Arg Asp Arg Pro 
        275                 280                 285             


Lys Arg Arg Gly Phe Asp Arg Phe Gly Pro Asp Gly Thr Gly Arg Lys 
    290                 295                 300                 


Arg Lys Gln Phe Gln Leu Tyr Glu Glu Pro Asp Thr Lys Leu Ala Arg 
305                 310                 315                 320 


Val Asp Ser Glu Gly Asp Phe Ser Glu Asn Asp Asp Ala Ala Gly Asp 
                325                 330                 335     


Phe Arg Ser Gly Asp Glu Glu Phe Lys Gly Glu Asp Glu Leu Cys Asp 
            340                 345                 350         


Ser Gly Arg Gln Arg Gly Glu Lys Glu Asp Glu Asp Glu Asp Val Lys 
        355                 360                 365             


Lys Arg Arg Glu Lys Gln Arg Arg Arg Asp Arg Thr Arg Asp Arg Ala 
    370                 375                 380                 


Ala Asp Arg Ile Gln Phe Ala Cys Ser Val Cys Lys Phe Arg Ser Phe 
385                 390                 395                 400 


Asp Asp Glu Glu Ile Gln Lys His Leu Gln Ser Lys Phe His Lys Glu 
                405                 410                 415     


Thr Leu Arg Phe Ile Ser Thr Lys Leu Pro Asp Lys Thr Val Glu Phe 
            420                 425                 430         


Leu Gln Glu Tyr Ile Val Asn Arg Asn Lys Lys Ile Glu Lys Arg Arg 
        435                 440                 445             


Gln Glu Leu Met Glu Lys Glu Thr Ala Lys Pro Lys Pro Asp Pro Phe 
    450                 455                 460                 


Lys Gly Ile Gly Gln Glu His Phe Phe Lys Lys Ile Glu Ala Ala His 
465                 470                 475                 480 


Cys Leu Ala Cys Asp Met Leu Ile Pro Ala Gln Pro Gln Leu Leu Gln 
                485                 490                 495     


Arg His Leu His Ser Val Asp His Asn His Asn Arg Arg Leu Ala Ala 
            500                 505                 510         


Glu Gln Phe Lys Lys Thr Ser Leu His Val Ala Lys Ser Val Leu Asn 
        515                 520                 525             


Asn Arg His Ile Val Lys Met Leu Glu Lys Tyr Leu Lys Gly Glu Asp 
    530                 535                 540                 


Pro Phe Thr Ser Glu Thr Val Asp Pro Glu Met Glu Gly Asp Asp Asn 
545                 550                 555                 560 


Leu Gly Gly Glu Asp Lys Lys Glu Thr Pro Glu Glu Val Ala Ala Asp 
                565                 570                 575     


Val Leu Ala Glu Val Ile Thr Ala Ala Val Arg Ala Val Asp Gly Glu 
            580                 585                 590         


Gly Ala Pro Ala Pro Glu Ser Ser Gly Glu Pro Ala Glu Asp Glu Gly 
        595                 600                 605             


Pro Thr Asp Thr Ala Glu Ala Gly Ser Asp Pro Gln Ala Glu Gln Leu 
    610                 615                 620                 


Leu Glu Glu Gln Val Pro Cys Gly Thr Ala His Glu Lys Gly Val Pro 
625                 630                 635                 640 


Lys Ala Arg Ser Glu Ala Ala Glu Ala Gly Asn Gly Ala Glu Thr Met 
                645                 650                 655     


Ala Ala Glu Ala Glu Ser Ala Gln Thr Arg Val Ala Pro Ala Pro Ala 
            660                 665                 670         


Ala Ala Asp Ala Glu Val Glu Gln Thr Asp Ala Glu Ser Lys Asp Ala 
        675                 680                 685             


Val Pro Thr Glu 
    690         


<210>  192
<211>  138
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9GZZ8
<309>  2016-09-07
<313>  (1)..(138)

<400>  192

Met Lys Phe Thr Thr Leu Leu Phe Leu Ala Ala Val Ala Gly Ala Leu 
1               5                   10                  15      


Val Tyr Ala Glu Asp Ala Ser Ser Asp Ser Thr Gly Ala Asp Pro Ala 
            20                  25                  30          


Gln Glu Ala Gly Thr Ser Lys Pro Asn Glu Glu Ile Ser Gly Pro Ala 
        35                  40                  45              


Glu Pro Ala Ser Pro Pro Glu Thr Thr Thr Thr Ala Gln Glu Thr Ser 
    50                  55                  60                  


Ala Ala Ala Val Gln Gly Thr Ala Lys Val Thr Ser Ser Arg Gln Glu 
65                  70                  75                  80  


Leu Asn Pro Leu Lys Ser Ile Val Glu Lys Ser Ile Leu Leu Thr Glu 
                85                  90                  95      


Gln Ala Leu Ala Lys Ala Gly Lys Gly Met His Gly Gly Val Pro Gly 
            100                 105                 110         


Gly Lys Gln Phe Ile Glu Asn Gly Ser Glu Phe Ala Gln Lys Leu Leu 
        115                 120                 125             


Lys Lys Phe Ser Leu Leu Lys Pro Trp Ala 
    130                 135             


<210>  193
<211>  217
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P62906
<309>  2016-09-07
<313>  (1)..(217)

<400>  193

Met Ser Ser Lys Val Ser Arg Asp Thr Leu Tyr Glu Ala Val Arg Glu 
1               5                   10                  15      


Val Leu His Gly Asn Gln Arg Lys Arg Arg Lys Phe Leu Glu Thr Val 
            20                  25                  30          


Glu Leu Gln Ile Ser Leu Lys Asn Tyr Asp Pro Gln Lys Asp Lys Arg 
        35                  40                  45              


Phe Ser Gly Thr Val Arg Leu Lys Ser Thr Pro Arg Pro Lys Phe Ser 
    50                  55                  60                  


Val Cys Val Leu Gly Asp Gln Gln His Cys Asp Glu Ala Lys Ala Val 
65                  70                  75                  80  


Asp Ile Pro His Met Asp Ile Glu Ala Leu Lys Lys Leu Asn Lys Asn 
                85                  90                  95      


Lys Lys Leu Val Lys Lys Leu Ala Lys Lys Tyr Asp Ala Phe Leu Ala 
            100                 105                 110         


Ser Glu Ser Leu Ile Lys Gln Ile Pro Arg Ile Leu Gly Pro Gly Leu 
        115                 120                 125             


Asn Lys Ala Gly Lys Phe Pro Ser Leu Leu Thr His Asn Glu Asn Met 
    130                 135                 140                 


Val Ala Lys Val Asp Glu Val Lys Ser Thr Ile Lys Phe Gln Met Lys 
145                 150                 155                 160 


Lys Val Leu Cys Leu Ala Val Ala Val Gly His Val Lys Met Thr Asp 
                165                 170                 175     


Asp Glu Leu Val Tyr Asn Ile His Leu Ala Val Asn Phe Leu Val Ser 
            180                 185                 190         


Leu Leu Lys Lys Asn Trp Gln Asn Val Arg Ala Leu Tyr Ile Lys Ser 
        195                 200                 205             


Thr Met Gly Lys Pro Gln Arg Leu Tyr 
    210                 215         


<210>  194
<211>  491
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P02675
<309>  1993-04-23
<313>  (1)..(491)

<400>  194

Met Lys Arg Met Val Ser Trp Ser Phe His Lys Leu Lys Thr Met Lys 
1               5                   10                  15      


His Leu Leu Leu Leu Leu Leu Cys Val Phe Leu Val Lys Ser Gln Gly 
            20                  25                  30          


Val Asn Asp Asn Glu Glu Gly Phe Phe Ser Ala Arg Gly His Arg Pro 
        35                  40                  45              


Leu Asp Lys Lys Arg Glu Glu Ala Pro Ser Leu Arg Pro Ala Pro Pro 
    50                  55                  60                  


Pro Ile Ser Gly Gly Gly Tyr Arg Ala Arg Pro Ala Lys Ala Ala Ala 
65                  70                  75                  80  


Thr Gln Lys Lys Val Glu Arg Lys Ala Pro Asp Ala Gly Gly Cys Leu 
                85                  90                  95      


His Ala Asp Pro Asp Leu Gly Val Leu Cys Pro Thr Gly Cys Gln Leu 
            100                 105                 110         


Gln Glu Ala Leu Leu Gln Gln Glu Arg Pro Ile Arg Asn Ser Val Asp 
        115                 120                 125             


Glu Leu Asn Asn Asn Val Glu Ala Val Ser Gln Thr Ser Ser Ser Ser 
    130                 135                 140                 


Phe Gln Tyr Met Tyr Leu Leu Lys Asp Leu Trp Gln Lys Arg Gln Lys 
145                 150                 155                 160 


Gln Val Lys Asp Asn Glu Asn Val Val Asn Glu Tyr Ser Ser Glu Leu 
                165                 170                 175     


Glu Lys His Gln Leu Tyr Ile Asp Glu Thr Val Asn Ser Asn Ile Pro 
            180                 185                 190         


Thr Asn Leu Arg Val Leu Arg Ser Ile Leu Glu Asn Leu Arg Ser Lys 
        195                 200                 205             


Ile Gln Lys Leu Glu Ser Asp Val Ser Ala Gln Met Glu Tyr Cys Arg 
    210                 215                 220                 


Thr Pro Cys Thr Val Ser Cys Asn Ile Pro Val Val Ser Gly Lys Glu 
225                 230                 235                 240 


Cys Glu Glu Ile Ile Arg Lys Gly Gly Glu Thr Ser Glu Met Tyr Leu 
                245                 250                 255     


Ile Gln Pro Asp Ser Ser Val Lys Pro Tyr Arg Val Tyr Cys Asp Met 
            260                 265                 270         


Asn Thr Glu Asn Gly Gly Trp Thr Val Ile Gln Asn Arg Gln Asp Gly 
        275                 280                 285             


Ser Val Asp Phe Gly Arg Lys Trp Asp Pro Tyr Lys Gln Gly Phe Gly 
    290                 295                 300                 


Asn Val Ala Thr Asn Thr Asp Gly Lys Asn Tyr Cys Gly Leu Pro Gly 
305                 310                 315                 320 


Glu Tyr Trp Leu Gly Asn Asp Lys Ile Ser Gln Leu Thr Arg Met Gly 
                325                 330                 335     


Pro Thr Glu Leu Leu Ile Glu Met Glu Asp Trp Lys Gly Asp Lys Val 
            340                 345                 350         


Lys Ala His Tyr Gly Gly Phe Thr Val Gln Asn Glu Ala Asn Lys Tyr 
        355                 360                 365             


Gln Ile Ser Val Asn Lys Tyr Arg Gly Thr Ala Gly Asn Ala Leu Met 
    370                 375                 380                 


Asp Gly Ala Ser Gln Leu Met Gly Glu Asn Arg Thr Met Thr Ile His 
385                 390                 395                 400 


Asn Gly Met Phe Phe Ser Thr Tyr Asp Arg Asp Asn Asp Gly Trp Leu 
                405                 410                 415     


Thr Ser Asp Pro Arg Lys Gln Cys Ser Lys Glu Asp Gly Gly Gly Trp 
            420                 425                 430         


Trp Tyr Asn Arg Cys His Ala Ala Asn Pro Asn Gly Arg Tyr Tyr Trp 
        435                 440                 445             


Gly Gly Gln Tyr Thr Trp Asp Met Ala Lys His Gly Thr Asp Asp Gly 
    450                 455                 460                 


Val Val Trp Met Asn Trp Lys Gly Ser Trp Tyr Ser Met Arg Lys Met 
465                 470                 475                 480 


Ser Met Lys Ile Arg Pro Phe Phe Pro Gln Gln 
                485                 490     


<210>  195
<211>  522
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / O43172
<309>  2002-05-09
<313>  (1)..(522)

<400>  195

Met Ala Ser Ser Arg Ala Ser Ser Thr Gln Ala Thr Lys Thr Lys Ala 
1               5                   10                  15      


Pro Asp Asp Leu Val Ala Pro Val Val Lys Lys Pro His Ile Tyr Tyr 
            20                  25                  30          


Gly Ser Leu Glu Glu Lys Glu Arg Glu Arg Leu Ala Lys Gly Glu Ser 
        35                  40                  45              


Gly Ile Leu Gly Lys Asp Gly Leu Lys Ala Gly Ile Glu Ala Gly Asn 
    50                  55                  60                  


Ile Asn Ile Thr Ser Gly Glu Val Phe Glu Ile Glu Glu His Ile Ser 
65                  70                  75                  80  


Glu Arg Gln Ala Glu Val Leu Ala Glu Phe Glu Arg Arg Lys Arg Ala 
                85                  90                  95      


Arg Gln Ile Asn Val Ser Thr Asp Asp Ser Glu Val Lys Ala Cys Leu 
            100                 105                 110         


Arg Ala Leu Gly Glu Pro Ile Thr Leu Phe Gly Glu Gly Pro Ala Glu 
        115                 120                 125             


Arg Arg Glu Arg Leu Arg Asn Ile Leu Ser Val Val Gly Thr Asp Ala 
    130                 135                 140                 


Leu Lys Lys Thr Lys Lys Asp Asp Glu Lys Ser Lys Lys Ser Lys Glu 
145                 150                 155                 160 


Glu Tyr Gln Gln Thr Trp Tyr His Glu Gly Pro Asn Ser Leu Lys Val 
                165                 170                 175     


Ala Arg Leu Trp Ile Ala Asn Tyr Ser Leu Pro Arg Ala Met Lys Arg 
            180                 185                 190         


Leu Glu Glu Ala Arg Leu His Lys Glu Ile Pro Glu Thr Thr Arg Thr 
        195                 200                 205             


Ser Gln Met Gln Glu Leu His Lys Ser Leu Arg Ser Leu Asn Asn Phe 
    210                 215                 220                 


Cys Ser Gln Ile Gly Asp Asp Arg Pro Ile Ser Tyr Cys His Phe Ser 
225                 230                 235                 240 


Pro Asn Ser Lys Met Leu Ala Thr Ala Cys Trp Ser Gly Leu Cys Lys 
                245                 250                 255     


Leu Trp Ser Val Pro Asp Cys Asn Leu Leu His Thr Leu Arg Gly His 
            260                 265                 270         


Asn Thr Asn Val Gly Ala Ile Val Phe His Pro Lys Ser Thr Val Ser 
        275                 280                 285             


Leu Asp Pro Lys Asp Val Asn Leu Ala Ser Cys Ala Ala Asp Gly Ser 
    290                 295                 300                 


Val Lys Leu Trp Ser Leu Asp Ser Asp Glu Pro Val Ala Asp Ile Glu 
305                 310                 315                 320 


Gly His Thr Val Arg Val Ala Arg Val Met Trp His Pro Ser Gly Arg 
                325                 330                 335     


Phe Leu Gly Thr Thr Cys Tyr Asp Arg Ser Trp Arg Leu Trp Asp Leu 
            340                 345                 350         


Glu Ala Gln Glu Glu Ile Leu His Gln Glu Gly His Ser Met Gly Val 
        355                 360                 365             


Tyr Asp Ile Ala Phe His Gln Asp Gly Ser Leu Ala Gly Thr Gly Gly 
    370                 375                 380                 


Leu Asp Ala Phe Gly Arg Val Trp Asp Leu Arg Thr Gly Arg Cys Ile 
385                 390                 395                 400 


Met Phe Leu Glu Gly His Leu Lys Glu Ile Tyr Gly Ile Asn Phe Ser 
                405                 410                 415     


Pro Asn Gly Tyr His Ile Ala Thr Gly Ser Gly Asp Asn Thr Cys Lys 
            420                 425                 430         


Val Trp Asp Leu Arg Gln Arg Arg Cys Val Tyr Thr Ile Pro Ala His 
        435                 440                 445             


Gln Asn Leu Val Thr Gly Val Lys Phe Glu Pro Ile His Gly Asn Phe 
    450                 455                 460                 


Leu Leu Thr Gly Ala Tyr Asp Asn Thr Ala Lys Ile Trp Thr His Pro 
465                 470                 475                 480 


Gly Trp Ser Pro Leu Lys Thr Leu Ala Gly His Glu Gly Lys Val Met 
                485                 490                 495     


Gly Leu Asp Ile Ser Ser Asp Gly Gln Leu Ile Ala Thr Cys Ser Tyr 
            500                 505                 510         


Asp Arg Thr Phe Lys Leu Trp Met Ala Glu 
        515                 520         


<210>  196
<211>  421
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q9BY77
<309>  2016-09-07
<313>  (1)..(421)

<400>  196

Met Ala Asp Ile Ser Leu Asp Glu Leu Ile Arg Lys Arg Gly Ala Ala 
1               5                   10                  15      


Ala Lys Gly Arg Leu Asn Ala Arg Pro Gly Val Gly Gly Val Arg Ser 
            20                  25                  30          


Arg Val Gly Ile Gln Gln Gly Leu Leu Ser Gln Ser Thr Arg Thr Ala 
        35                  40                  45              


Thr Phe Gln Gln Arg Phe Asp Ala Arg Gln Lys Ile Gly Leu Ser Asp 
    50                  55                  60                  


Ala Arg Leu Lys Leu Gly Val Lys Asp Ala Arg Glu Lys Leu Leu Gln 
65                  70                  75                  80  


Lys Asp Ala Arg Phe Arg Ile Lys Gly Lys Val Gln Asp Ala Arg Glu 
                85                  90                  95      


Met Leu Asn Ser Arg Lys Gln Gln Thr Thr Val Pro Gln Lys Pro Arg 
            100                 105                 110         


Gln Val Ala Asp Ala Arg Glu Lys Ile Ser Leu Lys Arg Ser Ser Pro 
        115                 120                 125             


Ala Ala Phe Ile Asn Pro Pro Ile Gly Thr Val Thr Pro Ala Leu Lys 
    130                 135                 140                 


Leu Thr Lys Thr Ile Gln Val Pro Gln Gln Lys Ala Met Ala Pro Leu 
145                 150                 155                 160 


His Pro His Pro Ala Gly Met Arg Ile Asn Val Val Asn Asn His Gln 
                165                 170                 175     


Ala Lys Gln Asn Leu Tyr Asp Leu Asp Glu Asp Asp Asp Gly Ile Ala 
            180                 185                 190         


Ser Val Pro Thr Lys Gln Met Lys Phe Ala Ala Ser Gly Gly Phe Leu 
        195                 200                 205             


His His Met Ala Gly Leu Ser Ser Ser Lys Leu Ser Met Ser Lys Ala 
    210                 215                 220                 


Leu Pro Leu Thr Lys Val Val Gln Asn Asp Ala Tyr Thr Ala Pro Ala 
225                 230                 235                 240 


Leu Pro Ser Ser Ile Arg Thr Lys Ala Leu Thr Asn Met Ser Arg Thr 
                245                 250                 255     


Leu Val Asn Lys Glu Glu Pro Pro Lys Glu Leu Pro Ala Ala Glu Pro 
            260                 265                 270         


Val Leu Ser Pro Leu Glu Gly Thr Lys Met Thr Val Asn Asn Leu His 
        275                 280                 285             


Pro Arg Val Thr Glu Glu Asp Ile Val Glu Leu Phe Cys Val Cys Gly 
    290                 295                 300                 


Ala Leu Lys Arg Ala Arg Leu Val His Pro Gly Val Ala Glu Val Val 
305                 310                 315                 320 


Phe Val Lys Lys Asp Asp Ala Ile Thr Ala Tyr Lys Lys Tyr Asn Asn 
                325                 330                 335     


Arg Cys Leu Asp Gly Gln Pro Met Lys Cys Asn Leu His Met Asn Gly 
            340                 345                 350         


Asn Val Ile Thr Ser Asp Gln Pro Ile Leu Leu Arg Leu Ser Asp Ser 
        355                 360                 365             


Pro Ser Met Lys Lys Glu Ser Glu Leu Pro Arg Arg Val Asn Ser Ala 
    370                 375                 380                 


Ser Ser Ser Asn Pro Pro Ala Glu Val Asp Pro Asp Thr Ile Leu Lys 
385                 390                 395                 400 


Ala Leu Phe Lys Ser Ser Gly Ala Ser Val Thr Thr Gln Pro Thr Glu 
                405                 410                 415     


Phe Lys Ile Lys Leu 
            420     


<210>  197
<211>  271
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P21964
<309>  1993-04-23
<313>  (1)..(271)

<400>  197

Met Pro Glu Ala Pro Pro Leu Leu Leu Ala Ala Val Leu Leu Gly Leu 
1               5                   10                  15      


Val Leu Leu Val Val Leu Leu Leu Leu Leu Arg His Trp Gly Trp Gly 
            20                  25                  30          


Leu Cys Leu Ile Gly Trp Asn Glu Phe Ile Leu Gln Pro Ile His Asn 
        35                  40                  45              


Leu Leu Met Gly Asp Thr Lys Glu Gln Arg Ile Leu Asn His Val Leu 
    50                  55                  60                  


Gln His Ala Glu Pro Gly Asn Ala Gln Ser Val Leu Glu Ala Ile Asp 
65                  70                  75                  80  


Thr Tyr Cys Glu Gln Lys Glu Trp Ala Met Asn Val Gly Asp Lys Lys 
                85                  90                  95      


Gly Lys Ile Val Asp Ala Val Ile Gln Glu His Gln Pro Ser Val Leu 
            100                 105                 110         


Leu Glu Leu Gly Ala Tyr Cys Gly Tyr Ser Ala Val Arg Met Ala Arg 
        115                 120                 125             


Leu Leu Ser Pro Gly Ala Arg Leu Ile Thr Ile Glu Ile Asn Pro Asp 
    130                 135                 140                 


Cys Ala Ala Ile Thr Gln Arg Met Val Asp Phe Ala Gly Val Lys Asp 
145                 150                 155                 160 


Lys Val Thr Leu Val Val Gly Ala Ser Gln Asp Ile Ile Pro Gln Leu 
                165                 170                 175     


Lys Lys Lys Tyr Asp Val Asp Thr Leu Asp Met Val Phe Leu Asp His 
            180                 185                 190         


Trp Lys Asp Arg Tyr Leu Pro Asp Thr Leu Leu Leu Glu Glu Cys Gly 
        195                 200                 205             


Leu Leu Arg Lys Gly Thr Val Leu Leu Ala Asp Asn Val Ile Cys Pro 
    210                 215                 220                 


Gly Ala Pro Asp Phe Leu Ala His Val Arg Gly Ser Ser Cys Phe Glu 
225                 230                 235                 240 


Cys Thr His Tyr Gln Ser Phe Leu Glu Tyr Arg Glu Val Val Asp Gly 
                245                 250                 255     


Leu Glu Lys Ala Ile Tyr Lys Gly Pro Gly Ser Glu Ala Gly Pro 
            260                 265                 270     


<210>  198
<211>  590
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / Q8IXH7
<309>  2016-09-07
<313>  (1)..(590)

<400>  198

Met Ala Gly Ala Val Pro Gly Ala Ile Met Asp Glu Asp Tyr Tyr Gly 
1               5                   10                  15      


Ser Ala Ala Glu Trp Gly Asp Glu Ala Asp Gly Gly Gln Gln Glu Asp 
            20                  25                  30          


Asp Ser Gly Glu Gly Glu Asp Asp Ala Glu Val Gln Gln Glu Cys Leu 
        35                  40                  45              


His Lys Phe Ser Thr Arg Asp Tyr Ile Met Glu Pro Ser Ile Phe Asn 
    50                  55                  60                  


Thr Leu Lys Arg Tyr Phe Gln Ala Gly Gly Ser Pro Glu Asn Val Ile 
65                  70                  75                  80  


Gln Leu Leu Ser Glu Asn Tyr Thr Ala Val Ala Gln Thr Val Asn Leu 
                85                  90                  95      


Leu Ala Glu Trp Leu Ile Gln Thr Gly Val Glu Pro Val Gln Val Gln 
            100                 105                 110         


Glu Thr Val Glu Asn His Leu Lys Ser Leu Leu Ile Lys His Phe Asp 
        115                 120                 125             


Pro Arg Lys Ala Asp Ser Ile Phe Thr Glu Glu Gly Glu Thr Pro Ala 
    130                 135                 140                 


Trp Leu Glu Gln Met Ile Ala His Thr Thr Trp Arg Asp Leu Phe Tyr 
145                 150                 155                 160 


Lys Leu Ala Glu Ala His Pro Asp Cys Leu Met Leu Asn Phe Thr Val 
                165                 170                 175     


Lys Leu Ile Ser Asp Ala Gly Tyr Gln Gly Glu Ile Thr Ser Val Ser 
            180                 185                 190         


Thr Ala Cys Gln Gln Leu Glu Val Phe Ser Arg Val Leu Arg Thr Ser 
        195                 200                 205             


Leu Ala Thr Ile Leu Asp Gly Gly Glu Glu Asn Leu Glu Lys Asn Leu 
    210                 215                 220                 


Pro Glu Phe Ala Lys Met Val Cys His Gly Glu His Thr Tyr Leu Phe 
225                 230                 235                 240 


Ala Gln Ala Met Met Ser Val Leu Ala Gln Glu Glu Gln Gly Gly Ser 
                245                 250                 255     


Ala Val Arg Arg Ile Ala Gln Glu Val Gln Arg Phe Ala Gln Glu Lys 
            260                 265                 270         


Gly His Asp Ala Ser Gln Ile Thr Leu Ala Leu Gly Thr Ala Ala Ser 
        275                 280                 285             


Tyr Pro Arg Ala Cys Gln Ala Leu Gly Ala Met Leu Ser Lys Gly Ala 
    290                 295                 300                 


Leu Asn Pro Ala Asp Ile Thr Val Leu Phe Lys Met Phe Thr Ser Met 
305                 310                 315                 320 


Asp Pro Pro Pro Val Glu Leu Ile Arg Val Pro Ala Phe Leu Asp Leu 
                325                 330                 335     


Phe Met Gln Ser Leu Phe Lys Pro Gly Ala Arg Ile Asn Gln Asp His 
            340                 345                 350         


Lys His Lys Tyr Ile His Ile Leu Ala Tyr Ala Ala Ser Val Val Glu 
        355                 360                 365             


Thr Trp Lys Lys Asn Lys Arg Val Ser Ile Asn Lys Asp Glu Leu Lys 
    370                 375                 380                 


Ser Thr Ser Lys Ala Val Glu Thr Val His Asn Leu Cys Cys Asn Glu 
385                 390                 395                 400 


Asn Lys Gly Ala Ser Glu Leu Val Ala Glu Leu Ser Thr Leu Tyr Gln 
                405                 410                 415     


Cys Ile Arg Phe Pro Val Val Ala Met Gly Val Leu Lys Trp Val Asp 
            420                 425                 430         


Trp Thr Val Ser Glu Pro Arg Tyr Phe Gln Leu Gln Thr Asp His Thr 
        435                 440                 445             


Pro Val His Leu Ala Leu Leu Asp Glu Ile Ser Thr Cys His Gln Leu 
    450                 455                 460                 


Leu His Pro Gln Val Leu Gln Leu Leu Val Lys Leu Phe Glu Thr Glu 
465                 470                 475                 480 


His Ser Gln Leu Asp Val Met Glu Gln Leu Glu Leu Lys Lys Thr Leu 
                485                 490                 495     


Leu Asp Arg Met Val His Leu Leu Ser Arg Gly Tyr Val Leu Pro Val 
            500                 505                 510         


Val Ser Tyr Ile Arg Lys Cys Leu Glu Lys Leu Asp Thr Asp Ile Ser 
        515                 520                 525             


Leu Ile Arg Tyr Phe Val Thr Glu Val Leu Asp Val Ile Ala Pro Pro 
    530                 535                 540                 


Tyr Thr Ser Asp Phe Val Gln Leu Phe Leu Pro Ile Leu Glu Asn Asp 
545                 550                 555                 560 


Ser Ile Ala Gly Thr Ile Lys Thr Glu Gly Glu His Asp Pro Val Thr 
                565                 570                 575     


Glu Phe Ile Ala His Cys Lys Ser Asn Phe Ile Met Val Asn 
            580                 585                 590 


<210>  199
<211>  641
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P0DMV8 replaces P08107
<309>  2016-09-07
<313>  (1)..(641)

<400>  199

Met Ala Lys Ala Ala Ala Ile Gly Ile Asp Leu Gly Thr Thr Tyr Ser 
1               5                   10                  15      


Cys Val Gly Val Phe Gln His Gly Lys Val Glu Ile Ile Ala Asn Asp 
            20                  25                  30          


Gln Gly Asn Arg Thr Thr Pro Ser Tyr Val Ala Phe Thr Asp Thr Glu 
        35                  40                  45              


Arg Leu Ile Gly Asp Ala Ala Lys Asn Gln Val Ala Leu Asn Pro Gln 
    50                  55                  60                  


Asn Thr Val Phe Asp Ala Lys Arg Leu Ile Gly Arg Lys Phe Gly Asp 
65                  70                  75                  80  


Pro Val Val Gln Ser Asp Met Lys His Trp Pro Phe Gln Val Ile Asn 
                85                  90                  95      


Asp Gly Asp Lys Pro Lys Val Gln Val Ser Tyr Lys Gly Glu Thr Lys 
            100                 105                 110         


Ala Phe Tyr Pro Glu Glu Ile Ser Ser Met Val Leu Thr Lys Met Lys 
        115                 120                 125             


Glu Ile Ala Glu Ala Tyr Leu Gly Tyr Pro Val Thr Asn Ala Val Ile 
    130                 135                 140                 


Thr Val Pro Ala Tyr Phe Asn Asp Ser Gln Arg Gln Ala Thr Lys Asp 
145                 150                 155                 160 


Ala Gly Val Ile Ala Gly Leu Asn Val Leu Arg Ile Ile Asn Glu Pro 
                165                 170                 175     


Thr Ala Ala Ala Ile Ala Tyr Gly Leu Asp Arg Thr Gly Lys Gly Glu 
            180                 185                 190         


Arg Asn Val Leu Ile Phe Asp Leu Gly Gly Gly Thr Phe Asp Val Ser 
        195                 200                 205             


Ile Leu Thr Ile Asp Asp Gly Ile Phe Glu Val Lys Ala Thr Ala Gly 
    210                 215                 220                 


Asp Thr His Leu Gly Gly Glu Asp Phe Asp Asn Arg Leu Val Asn His 
225                 230                 235                 240 


Phe Val Glu Glu Phe Lys Arg Lys His Lys Lys Asp Ile Ser Gln Asn 
                245                 250                 255     


Lys Arg Ala Val Arg Arg Leu Arg Thr Ala Cys Glu Arg Ala Lys Arg 
            260                 265                 270         


Thr Leu Ser Ser Ser Thr Gln Ala Ser Leu Glu Ile Asp Ser Leu Phe 
        275                 280                 285             


Glu Gly Ile Asp Phe Tyr Thr Ser Ile Thr Arg Ala Arg Phe Glu Glu 
    290                 295                 300                 


Leu Cys Ser Asp Leu Phe Arg Ser Thr Leu Glu Pro Val Glu Lys Ala 
305                 310                 315                 320 


Leu Arg Asp Ala Lys Leu Asp Lys Ala Gln Ile His Asp Leu Val Leu 
                325                 330                 335     


Val Gly Gly Ser Thr Arg Ile Pro Lys Val Gln Lys Leu Leu Gln Asp 
            340                 345                 350         


Phe Phe Asn Gly Arg Asp Leu Asn Lys Ser Ile Asn Pro Asp Glu Ala 
        355                 360                 365             


Val Ala Tyr Gly Ala Ala Val Gln Ala Ala Ile Leu Met Gly Asp Lys 
    370                 375                 380                 


Ser Glu Asn Val Gln Asp Leu Leu Leu Leu Asp Val Ala Pro Leu Ser 
385                 390                 395                 400 


Leu Gly Leu Glu Thr Ala Gly Gly Val Met Thr Ala Leu Ile Lys Arg 
                405                 410                 415     


Asn Ser Thr Ile Pro Thr Lys Gln Thr Gln Ile Phe Thr Thr Tyr Ser 
            420                 425                 430         


Asp Asn Gln Pro Gly Val Leu Ile Gln Val Tyr Glu Gly Glu Arg Ala 
        435                 440                 445             


Met Thr Lys Asp Asn Asn Leu Leu Gly Arg Phe Glu Leu Ser Gly Ile 
    450                 455                 460                 


Pro Pro Ala Pro Arg Gly Val Pro Gln Ile Glu Val Thr Phe Asp Ile 
465                 470                 475                 480 


Asp Ala Asn Gly Ile Leu Asn Val Thr Ala Thr Asp Lys Ser Thr Gly 
                485                 490                 495     


Lys Ala Asn Lys Ile Thr Ile Thr Asn Asp Lys Gly Arg Leu Ser Lys 
            500                 505                 510         


Glu Glu Ile Glu Arg Met Val Gln Glu Ala Glu Lys Tyr Lys Ala Glu 
        515                 520                 525             


Asp Glu Val Gln Arg Glu Arg Val Ser Ala Lys Asn Ala Leu Glu Ser 
    530                 535                 540                 


Tyr Ala Phe Asn Met Lys Ser Ala Val Glu Asp Glu Gly Leu Lys Gly 
545                 550                 555                 560 


Lys Ile Ser Glu Ala Asp Lys Lys Lys Val Leu Asp Lys Cys Gln Glu 
                565                 570                 575     


Val Ile Ser Trp Leu Asp Ala Asn Thr Leu Ala Glu Lys Asp Glu Phe 
            580                 585                 590         


Glu His Lys Arg Lys Glu Leu Glu Gln Val Cys Asn Pro Ile Ile Ser 
        595                 600                 605             


Gly Leu Tyr Gln Gly Ala Gly Gly Pro Gly Pro Gly Gly Phe Gly Ala 
    610                 615                 620                 


Gln Gly Pro Lys Gly Gly Ser Gly Ser Gly Pro Thr Ile Glu Glu Val 
625                 630                 635                 640 


Asp 
    


<210>  200
<211>  135
<212>  PRT
<213>  Homo sapiens

<300>
<308>  UniProt / P08708 replaces P0CW22
<309>  2016-09-07
<313>  (1)..(135)

<400>  200

Met Gly Arg Val Arg Thr Lys Thr Val Lys Lys Ala Ala Arg Val Ile 
1               5                   10                  15      


Ile Glu Lys Tyr Tyr Thr Arg Leu Gly Asn Asp Phe His Thr Asn Lys 
            20                  25                  30          


Arg Val Cys Glu Glu Ile Ala Ile Ile Pro Ser Lys Lys Leu Arg Asn 
        35                  40                  45              


Lys Ile Ala Gly Tyr Val Thr His Leu Met Lys Arg Ile Gln Arg Gly 
    50                  55                  60                  


Pro Val Arg Gly Ile Ser Ile Lys Leu Gln Glu Glu Glu Arg Glu Arg 
65                  70                  75                  80  


Arg Asp Asn Tyr Val Pro Glu Val Ser Ala Leu Asp Gln Glu Ile Ile 
                85                  90                  95      


Glu Val Asp Pro Asp Thr Lys Glu Met Leu Lys Leu Leu Asp Phe Gly 
            100                 105                 110         


Ser Leu Ser Asn Leu Gln Val Thr Gln Pro Thr Val Gly Met Asn Phe 
        115                 120                 125             


Lys Thr Pro Arg Gly Pro Val 
    130                 135 


