                         SEQUENCE LISTING

<110>  University of Copenhagen
 
<120>  Peptide Dual Agonists of GIPR and GLP2R

<130>  P4334PC00

<150>  DK 2016 70799
<151>  2016-10-12

<160>  33    

<170>  PatentIn version 3.5

<210>  1
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-1


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  1

His Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  2
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-2


<220>
<221>  PEPTIDE
<222>  (1)..(42)

<400>  2

His Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  3
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-3


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  3

His Ala Asp Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  4
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-4


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  4

His Ala Glu Gly Ser Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  5
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-5


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  5

His Ala Glu Gly Thr Phe Ser Asp Glu Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  6
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-6


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  6

His Ala Glu Gly Thr Phe Ile Ser Asp Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  7
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-7


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  7

His Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  8
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-8


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  8

His Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  9
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-9


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  9

His Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  10
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-10


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  10

His Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Gly Lys 
            20                  25                  30          


Lys 
    


<210>  11
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-11


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  11

His Gly Asp Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  12
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-12


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  12

His Val Asp Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  13
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-13


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  13

His Ala Asp Gly Thr Phe Ser Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  14
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-14


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  14

His Ala Asp Gly Thr Phe Ile Asp Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  15
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-15


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  15

His Ala Asp Gly Thr Phe Ile Ser Glu Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  16
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-16


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  16

His Ala Asp Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Gly Thr 
            20                  25                  30          


Asp 
    


<210>  17
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-17


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  17

His Ala Asp Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Lys 
            20                  25                  30          


Asp 
    


<210>  18
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-18


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  18

His Ala Asp Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Lys 
    


<210>  19
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-19


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  19

His Ala Asp Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Gly Lys 
            20                  25                  30          


Lys 
    


<210>  20
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus 1


<220>
<221>  misc_feature
<223>  X (p.2)=A, G, V; X (p.3)=D, E; X (p.5)=T, S; X (p.7)=I, S; X 
       (p.8)=S, D; X (p.9)=D, E; X (p.10)=Y, M; X (p.11)=S, N; X 
       (p.12)=T, I;X (p.13)=I, A; X (p.14)=L, M; X (p.23)=I, V; X 
       (p.27)=I, L; X (p.28)=Q,A;X (p.29)=T,Q;X (p.31)=I,G;X 
       

<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  20

His Xaa Xaa Gly Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Xaa Asn Trp Leu Xaa Xaa Xaa Lys Xaa Xaa 
            20                  25                  30          


Xaa 
    


<210>  21
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus 2


<220>
<221>  PEPTIDE
<222>  (1)..(33)
<223>  X (p.2)=A, G; X (p.3)=D, E;  X (p.23)=I, V; X (p.27)=I, L; X 
       (p.28)=Q,A; X (p.29)=T,Q; X (p.31)=I,G; X (p.32)=T,K; X 
       (p.33)=D,K

<400>  21

His Xaa Xaa Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Xaa Asn Trp Leu Xaa Xaa Xaa Lys Xaa Xaa 
            20                  25                  30          


Xaa 
    


<210>  22
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  22

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  23
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  23

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  24
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus 3


<220>
<221>  PEPTIDE
<222>  (1)..(33)
<223>  X=A,G,V

<400>  24

His Xaa Asp Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  25
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminus


<220>
<221>  PEPTIDE
<222>  (1)..(9)

<400>  25

Asn Asp Trp Lys His Asn Ile Thr Gln 
1               5                   


<210>  26
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-20


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  26

His Ala Asp Gly Thr Phe Ser Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Lys Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  27
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-24


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  27

His Ala Asp Gly Thr Phe Ile Ser Asp Tyr Ser Lys Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Lys 
    


<210>  28
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-25


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  28

His Ala Asp Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Lys Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Lys 
    


<210>  29
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-26


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  29

His Ala Asp Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Lys 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Lys 
    


<210>  30
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-27


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  30

His Ala Asp Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Lys Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Lys 
    


<210>  31
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-28


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<400>  31

His Ala Asp Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Lys Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Lys 
    


<210>  32
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Co-34


<220>
<221>  PEPTIDE
<222>  (1)..(42)

<400>  32

His Ala Asp Gly Thr Phe Ile Ser Asp Tyr Ser Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  33
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Consensus 4


<220>
<221>  PEPTIDE
<222>  (1)..(33)

<220>
<221>  PEPTIDE
<222>  (1)..(33)
<223>  X(p.2)=A,G,V;X(p.3)=D,E;X(p.5)=T,S;X(p.7)=I,S;X(p.8)=S,D;X(p.9)=D
       ,E;X(p.10)=Y,M;X(p.11)=S,N;X(p.12)=T,I,K;X(p.13)=I,A;X(p.14)=L,M,
       K;X(p.16)=N,K;X(p.18)=A,K;X(p.20)=A,K;X(p.23)=I,V;X(p.27)=I,L;X(p
       .28)=Q,A;X(p.29)=T,Q;X(p.31)=I,G;X(p.32)=T,K;X(p.33)=D,K

<400>  33

His Xaa Xaa Gly Xaa Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa 
1               5                   10                  15      


Leu Xaa Ala Xaa Asp Phe Xaa Asn Trp Leu Xaa Xaa Xaa Lys Xaa Xaa 
            20                  25                  30          


Xaa 
    


