                         SEQUENCE LISTING

<110>  University of Cape Town
 
<120>  Production of Soluble HIV Envelope Trimers In Planta

<130>  PA166256/P

<160>  22    

<170>  PatentIn version 3.5

<210>  1
<211>  853
<212>  PRT
<213>  HIV-1

<400>  1

Met Thr Val Thr Gly Thr Trp Arg Asn Tyr Gln Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Ile Leu Gly Phe Trp Met Leu Met Ile Cys Asn Gly Leu Trp Val 
            20                  25                  30          


Thr Val Tyr Tyr Gly Val Pro Val Trp Arg Glu Ala Lys Thr Thr Leu 
        35                  40                  45              


Phe Cys Ala Ser Asp Ala Lys Ser Tyr Glu Lys Glu Val His Asn Val 
    50                  55                  60                  


Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Leu 
65                  70                  75                  80  


Val Leu Lys Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met 
                85                  90                  95      


Val Asp Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu 
            100                 105                 110         


Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Ser 
        115                 120                 125             


Asp Ala Lys Val Asn Ile Asn Ala Thr Tyr Asn Gly Thr Arg Glu Glu 
    130                 135                 140                 


Ile Lys Asn Cys Ser Phe Asn Ala Thr Thr Glu Leu Arg Asp Lys Lys 
145                 150                 155                 160 


Lys Lys Glu Tyr Ala Leu Phe Tyr Arg Leu Asp Ile Val Pro Leu Asn 
                165                 170                 175     


Lys Glu Gly Asn Asn Asn Ser Glu Tyr Arg Leu Ile Asn Cys Asn Thr 
            180                 185                 190         


Ser Val Ile Thr Gln Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro 
        195                 200                 205             


Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn 
    210                 215                 220                 


Lys Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln 
225                 230                 235                 240 


Cys Thr His Gly Ile Lys Pro Val Val Ser Thr Gln Leu Leu Leu Asn 
                245                 250                 255     


Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr 
            260                 265                 270         


Asp Asn Val Lys Thr Ile Ile Val His Leu Asn Glu Ser Val Glu Ile 
        275                 280                 285             


Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly 
    290                 295                 300                 


Pro Gly Gln Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg 
305                 310                 315                 320 


Gln Ala His Cys Asn Ile Ser Glu Ile Lys Trp Glu Lys Thr Leu Gln 
                325                 330                 335     


Arg Val Ser Glu Lys Leu Arg Glu His Phe Asn Lys Thr Ile Ile Phe 
            340                 345                 350         


Asn Gln Ser Ser Gly Gly Asp Leu Glu Ile Thr Thr His Ser Phe Asn 
        355                 360                 365             


Cys Gly Gly Glu Phe Phe Tyr Cys Asn Thr Ser Asp Leu Phe Phe Asn 
    370                 375                 380                 


Lys Thr Phe Asp Glu Thr Tyr Ser Thr Gly Ser Asn Ser Thr Asn Ser 
385                 390                 395                 400 


Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
                405                 410                 415     


Glu Val Gly Arg Ala Met Tyr Ala Ser Pro Ile Ala Gly Glu Ile Thr 
            420                 425                 430         


Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Gly 
        435                 440                 445             


Asn Asn Ser Thr Glu Glu Thr Phe Arg Pro Gly Gly Gly Asn Met Arg 
    450                 455                 460                 


Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Val Lys 
465                 470                 475                 480 


Pro Leu Gly Ile Ala Pro Thr Glu Ala Arg Arg Arg Val Val Gln Lys 
                485                 490                 495     


Glu Lys Arg Ala Val Val Gly Leu Gly Ala Val Phe Leu Gly Phe Leu 
            500                 505                 510         


Gly Thr Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
        515                 520                 525             


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
    530                 535                 540                 


Leu Arg Ala Ile Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp 
545                 550                 555                 560 


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu Arg Tyr Leu 
                565                 570                 575     


Lys Asp Gln Gln Leu Leu Gly Met Trp Gly Cys Ser Gly Lys Leu Ile 
            580                 585                 590         


Cys Thr Thr Asn Val Tyr Trp Asn Ser Ser Trp Ser Asn Lys Thr Tyr 
        595                 600                 605             


Asn Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile 
    610                 615                 620                 


Asp Asn Tyr Thr Asp Thr Ile Tyr Lys Leu Leu Glu Val Ser Gln Lys 
625                 630                 635                 640 


Gln Gln Glu Ser Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Asn 
                645                 650                 655     


Asn Leu Trp Asn Trp Phe Asp Ile Ser Lys Trp Leu Trp Tyr Ile Lys 
            660                 665                 670         


Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe 
        675                 680                 685             


Ala Val Leu Ser Leu Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu 
    690                 695                 700                 


Ser Phe Gln Thr Leu Thr Pro Asn Pro Arg Glu Leu Asp Arg Leu Gly 
705                 710                 715                 720 


Gly Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg 
                725                 730                 735     


Leu Val Ser Gly Phe Phe Ser Leu Ala Trp Asn Asp Leu Arg Ser Leu 
            740                 745                 750         


Cys Leu Phe Cys Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala Gly 
        755                 760                 765             


Arg Ala Val Glu Leu Leu Gly Arg Ser Ser Leu Gln Gly Leu Gln Arg 
    770                 775                 780                 


Gly Trp Glu Ile Leu Lys Tyr Leu Gly Ser Leu Val Gln Tyr Trp Gly 
785                 790                 795                 800 


Leu Glu Leu Lys Lys Ser Ala Ile Asn Leu Phe Asp Thr Ile Ala Ile 
                805                 810                 815     


Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Glu Phe Leu Gln Arg 
            820                 825                 830         


Ile Val Arg Ala Ile Leu His Ile Pro Arg Arg Ile Arg Gln Gly Phe 
        835                 840                 845             


Glu Ala Ala Leu Gln 
    850             


<210>  2
<211>  844
<212>  PRT
<213>  HIV-1

<400>  2

Met Arg Val Met Gly Ile Gln Arg Asn Trp Pro Gln Trp Trp Ile Trp 
1               5                   10                  15      


Gly Thr Leu Gly Phe Trp Met Ile Ile Ile Cys Arg Val Val Gly Asn 
            20                  25                  30          


Leu Asn Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu 
        35                  40                  45              


Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Lys 
    50                  55                  60                  


Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro 
65                  70                  75                  80  


Asn Pro Arg Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met 
                85                  90                  95      


Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp Ile Ile Ser Leu 
            100                 105                 110         


Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val 
        115                 120                 125             


Thr Leu Asn Cys Thr Asn Ala Pro Ala Tyr Asn Asn Ser Met His Gly 
    130                 135                 140                 


Glu Met Lys Asn Cys Ser Phe Asn Thr Thr Thr Glu Ile Arg Asp Arg 
145                 150                 155                 160 


Lys Gln Lys Ala Tyr Ala Leu Phe Tyr Lys Pro Asp Val Val Pro Leu 
                165                 170                 175     


Asn Arg Arg Glu Glu Asn Asn Gly Thr Gly Glu Tyr Ile Leu Ile Asn 
            180                 185                 190         


Cys Asn Ser Ser Thr Ile Thr Gln Ala Cys Pro Lys Val Thr Phe Asp 
        195                 200                 205             


Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Tyr Ala Ile Leu Lys 
    210                 215                 220                 


Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Asn Asn Val Ser 
225                 230                 235                 240 


Thr Val Gln Cys Thr His Gly Ile Met Pro Val Val Ser Thr Gln Leu 
                245                 250                 255     


Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Ile Ile Ile Arg Ser Glu 
            260                 265                 270         


Asn Leu Thr Asn Asn Ile Lys Thr Ile Ile Val His Leu Asn Lys Ser 
        275                 280                 285             


Val Glu Ile Val Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile 
    290                 295                 300                 


Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala Thr Gly Glu Ile Ile Gly 
305                 310                 315                 320 


Asn Ile Arg Glu Ala His Cys Asn Ile Ser Lys Ser Asn Trp Thr Ser 
                325                 330                 335     


Thr Leu Glu Gln Val Lys Lys Lys Leu Lys Glu His Tyr Asn Lys Thr 
            340                 345                 350         


Ile Glu Phe Asn Pro Pro Ser Gly Gly Asp Leu Glu Val Thr Thr His 
        355                 360                 365             


Ser Phe Asn Cys Arg Gly Glu Phe Phe Tyr Cys Asn Thr Thr Lys Leu 
    370                 375                 380                 


Phe Ser Asn Asn Ser Asp Ser Asn Asn Glu Thr Ile Thr Leu Pro Cys 
385                 390                 395                 400 


Lys Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Arg Ala Met 
                405                 410                 415     


Tyr Ala Pro Pro Ile Glu Gly Asn Ile Thr Cys Lys Ser Asn Ile Thr 
            420                 425                 430         


Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Asn Thr Thr Asn Glu Ile 
        435                 440                 445             


Phe Arg Pro Gly Gly Gly Asn Met Lys Asp Asn Trp Arg Ser Glu Leu 
    450                 455                 460                 


Tyr Lys Tyr Lys Val Val Glu Ile Glu Pro Leu Gly Val Ala Pro Thr 
465                 470                 475                 480 


Lys Ser Lys Arg Arg Val Val Glu Arg Glu Lys Arg Ala Val Gly Leu 
                485                 490                 495     


Gly Ala Val Leu Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
            500                 505                 510         


Ala Ala Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly 
        515                 520                 525             


Ile Val Gln Gln Gln Ser Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln 
    530                 535                 540                 


His Met Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg 
545                 550                 555                 560 


Val Leu Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu 
                565                 570                 575     


Trp Gly Cys Ser Gly Lys Ile Ile Cys Thr Thr Ala Val Pro Trp Asn 
            580                 585                 590         


Ser Ser Trp Ser Asn Lys Ser Gln Glu Asp Ile Trp Asp Asn Met Thr 
        595                 600                 605             


Trp Met Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Gly Thr Ile Tyr 
    610                 615                 620                 


Arg Leu Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu Lys Asp 
625                 630                 635                 640 


Leu Leu Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn Trp Phe Asn Ile 
                645                 650                 655     


Thr Asn Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly 
            660                 665                 670         


Leu Ile Gly Leu Arg Ile Ile Phe Gly Val Leu Ala Ile Val Lys Arg 
        675                 680                 685             


Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro Ser 
    690                 695                 700                 


Pro Arg Gly Pro Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu 
705                 710                 715                 720 


Gln Asp Lys Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu 
                725                 730                 735     


Ala Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His His Leu 
            740                 745                 750         


Arg Asp Phe Ile Leu Ile Ala Ala Arg Ala Ala Glu Leu Leu Gly Arg 
        755                 760                 765             


Ser Ser Leu Arg Gly Leu Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu 
    770                 775                 780                 


Gly Asn Leu Val Gln Tyr Gly Gly Leu Glu Leu Lys Arg Ser Ala Ile 
785                 790                 795                 800 


Lys Leu Phe Asp Thr Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg 
                805                 810                 815     


Ile Leu Glu Val Ile Gln Arg Ile Cys Arg Ala Ile Arg His Ile Pro 
            820                 825                 830         


Ile Arg Ile Arg Gln Gly Phe Glu Ala Ala Leu Gln 
        835                 840                 


<210>  3
<211>  656
<212>  PRT
<213>  Artificial

<220>
<223>  CAP256SU Gp140NFL

<400>  3

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Ser Gly Gly Leu Trp Val Thr Val Tyr Tyr Gly Val Pro 
            20                  25                  30          


Val Trp Arg Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
        35                  40                  45              


Ser Tyr Glu Lys Glu Val His Asn Val Trp Ala Thr His Ala Cys Val 
    50                  55                  60                  


Pro Thr Asp Pro Asn Pro Gln Glu Leu Val Leu Lys Asn Val Thr Glu 
65                  70                  75                  80  


Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp 
                85                  90                  95      


Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr 
            100                 105                 110         


Pro Leu Cys Val Thr Leu Asn Cys Ser Asp Ala Lys Val Asn Ile Asn 
        115                 120                 125             


Ala Thr Tyr Asn Gly Thr Arg Glu Glu Ile Lys Asn Cys Ser Phe Asn 
    130                 135                 140                 


Ala Thr Thr Glu Leu Arg Asp Lys Lys Lys Lys Glu Tyr Ala Leu Phe 
145                 150                 155                 160 


Tyr Arg Leu Asp Ile Val Pro Leu Asn Lys Glu Gly Asn Asn Asn Ser 
                165                 170                 175     


Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys 
            180                 185                 190         


Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
        195                 200                 205             


Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly 
    210                 215                 220                 


Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
225                 230                 235                 240 


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu 
                245                 250                 255     


Ile Ile Ile Arg Ser Glu Asn Leu Thr Asp Asn Val Lys Thr Ile Ile 
            260                 265                 270         


Val His Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
        275                 280                 285             


Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala 
    290                 295                 300                 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser 
305                 310                 315                 320 


Glu Ile Lys Trp Glu Lys Thr Leu Gln Arg Val Ser Glu Lys Leu Arg 
                325                 330                 335     


Glu His Phe Asn Lys Thr Ile Ile Phe Asn Gln Ser Ser Gly Gly Asp 
            340                 345                 350         


Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
        355                 360                 365             


Cys Asn Thr Ser Asp Leu Phe Phe Asn Lys Thr Phe Asp Glu Thr Tyr 
    370                 375                 380                 


Ser Thr Gly Ser Asn Ser Thr Asn Ser Thr Ile Thr Leu Pro Cys Arg 
385                 390                 395                 400 


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr 
                405                 410                 415     


Ala Ser Pro Ile Ala Gly Glu Ile Thr Cys Lys Ser Asn Ile Thr Gly 
            420                 425                 430         


Leu Leu Leu Thr Arg Asp Gly Gly Gly Asn Asn Ser Thr Glu Glu Thr 
        435                 440                 445             


Phe Arg Pro Gly Gly Gly Asn Met Arg Asp Asn Trp Arg Ser Glu Leu 
    450                 455                 460                 


Tyr Lys Tyr Lys Val Val Glu Val Lys Pro Leu Gly Ile Ala Pro Thr 
465                 470                 475                 480 


Glu Ala Arg Arg Arg Val Val Gln Gln Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Ala Val Val Gly Leu Gly Ala Val Phe Leu Gly Phe Leu 
            500                 505                 510         


Gly Thr Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
        515                 520                 525             


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
    530                 535                 540                 


Leu Arg Ala Pro Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp 
545                 550                 555                 560 


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu Arg Tyr Leu 
                565                 570                 575     


Lys Asp Gln Gln Leu Leu Gly Met Trp Gly Cys Ser Gly Lys Leu Ile 
            580                 585                 590         


Cys Thr Thr Asn Val Tyr Trp Asn Ser Ser Trp Ser Asn Lys Thr Tyr 
        595                 600                 605             


Asn Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile 
    610                 615                 620                 


Asp Asn Tyr Thr Asp Thr Ile Tyr Lys Leu Leu Glu Val Ser Gln Lys 
625                 630                 635                 640 


Gln Gln Glu Ser Asn Glu Lys Asp Leu Leu Ala Leu Asp Ala Ala Ala 
                645                 650                 655     


<210>  4
<211>  709
<212>  PRT
<213>  Artificial

<220>
<223>  CAP256SU Gp140FL fused to HA2 of influenza

<400>  4

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Ser Gly Gly Leu Trp Val Thr Val Tyr Tyr Gly Val Pro 
            20                  25                  30          


Val Trp Arg Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
        35                  40                  45              


Ser Tyr Glu Lys Glu Val His Asn Val Trp Ala Thr His Ala Cys Val 
    50                  55                  60                  


Pro Thr Asp Pro Asn Pro Gln Glu Leu Val Leu Lys Asn Val Thr Glu 
65                  70                  75                  80  


Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp 
                85                  90                  95      


Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr 
            100                 105                 110         


Pro Leu Cys Val Thr Leu Asn Cys Ser Asp Ala Lys Val Asn Ile Asn 
        115                 120                 125             


Ala Thr Tyr Asn Gly Thr Arg Glu Glu Ile Lys Asn Cys Ser Phe Asn 
    130                 135                 140                 


Ala Thr Thr Glu Leu Arg Asp Lys Lys Lys Lys Glu Tyr Ala Leu Phe 
145                 150                 155                 160 


Tyr Arg Leu Asp Ile Val Pro Leu Asn Lys Glu Gly Asn Asn Asn Ser 
                165                 170                 175     


Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys 
            180                 185                 190         


Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
        195                 200                 205             


Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly 
    210                 215                 220                 


Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
225                 230                 235                 240 


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu 
                245                 250                 255     


Ile Ile Ile Arg Ser Glu Asn Leu Thr Asp Asn Val Lys Thr Ile Ile 
            260                 265                 270         


Val His Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
        275                 280                 285             


Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala 
    290                 295                 300                 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser 
305                 310                 315                 320 


Glu Ile Lys Trp Glu Lys Thr Leu Gln Arg Val Ser Glu Lys Leu Arg 
                325                 330                 335     


Glu His Phe Asn Lys Thr Ile Ile Phe Asn Gln Ser Ser Gly Gly Asp 
            340                 345                 350         


Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
        355                 360                 365             


Cys Asn Thr Ser Asp Leu Phe Phe Asn Lys Thr Phe Asp Glu Thr Tyr 
    370                 375                 380                 


Ser Thr Gly Ser Asn Ser Thr Asn Ser Thr Ile Thr Leu Pro Cys Arg 
385                 390                 395                 400 


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr 
                405                 410                 415     


Ala Ser Pro Ile Ala Gly Glu Ile Thr Cys Lys Ser Asn Ile Thr Gly 
            420                 425                 430         


Leu Leu Leu Thr Arg Asp Gly Gly Gly Asn Asn Ser Thr Glu Glu Thr 
        435                 440                 445             


Phe Arg Pro Gly Gly Gly Asn Met Arg Asp Asn Trp Arg Ser Glu Leu 
    450                 455                 460                 


Tyr Lys Tyr Lys Val Val Glu Val Lys Pro Leu Gly Ile Ala Pro Thr 
465                 470                 475                 480 


Glu Ala Arg Arg Arg Val Val Gln Gln Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Ala Val Val Gly Leu Gly Ala Val Phe Leu Gly Phe Leu 
            500                 505                 510         


Gly Thr Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
        515                 520                 525             


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
    530                 535                 540                 


Leu Arg Ala Pro Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp 
545                 550                 555                 560 


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu Arg Tyr Leu 
                565                 570                 575     


Lys Asp Gln Gln Leu Leu Gly Met Trp Gly Cys Ser Gly Lys Leu Ile 
            580                 585                 590         


Cys Thr Thr Asn Val Tyr Trp Asn Ser Ser Trp Ser Asn Lys Thr Tyr 
        595                 600                 605             


Asn Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile 
    610                 615                 620                 


Asp Asn Tyr Thr Asp Thr Ile Tyr Lys Leu Leu Glu Val Ser Gln Lys 
625                 630                 635                 640 


Gln Gln Glu Ser Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Asn 
                645                 650                 655     


Asn Leu Trp Asn Trp Phe Asp Ile Ser Lys Trp Leu Trp Tyr Ile Gln 
            660                 665                 670         


Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile 
        675                 680                 685             


Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln 
    690                 695                 700                 


Cys Arg Ala Ala Ala 
705                 


<210>  5
<211>  711
<212>  PRT
<213>  Artificial

<220>
<223>  CAP256SU Gp120FL fused to HA2 of influenza

<400>  5

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Ser Gly Gly Leu Trp Val Thr Val Tyr Tyr Gly Val Pro 
            20                  25                  30          


Val Trp Arg Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
        35                  40                  45              


Ser Tyr Glu Lys Glu Val His Asn Val Trp Ala Thr His Ala Cys Val 
    50                  55                  60                  


Pro Thr Asp Pro Asn Pro Gln Glu Leu Val Leu Lys Asn Val Thr Glu 
65                  70                  75                  80  


Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp 
                85                  90                  95      


Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr 
            100                 105                 110         


Pro Leu Cys Val Thr Leu Asn Cys Ser Asp Ala Lys Val Asn Ile Asn 
        115                 120                 125             


Ala Thr Tyr Asn Gly Thr Arg Glu Glu Ile Lys Asn Cys Ser Phe Asn 
    130                 135                 140                 


Ala Thr Thr Glu Leu Arg Asp Lys Lys Lys Lys Glu Tyr Ala Leu Phe 
145                 150                 155                 160 


Tyr Arg Leu Asp Ile Val Pro Leu Asn Lys Glu Gly Asn Asn Asn Ser 
                165                 170                 175     


Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys 
            180                 185                 190         


Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
        195                 200                 205             


Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly 
    210                 215                 220                 


Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
225                 230                 235                 240 


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu 
                245                 250                 255     


Ile Ile Ile Arg Ser Glu Asn Leu Thr Asp Asn Val Lys Thr Ile Ile 
            260                 265                 270         


Val His Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
        275                 280                 285             


Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala 
    290                 295                 300                 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser 
305                 310                 315                 320 


Glu Ile Lys Trp Glu Lys Thr Leu Gln Arg Val Ser Glu Lys Leu Arg 
                325                 330                 335     


Glu His Phe Asn Lys Thr Ile Ile Phe Asn Gln Ser Ser Gly Gly Asp 
            340                 345                 350         


Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
        355                 360                 365             


Cys Asn Thr Ser Asp Leu Phe Phe Asn Lys Thr Phe Asp Glu Thr Tyr 
    370                 375                 380                 


Ser Thr Gly Ser Asn Ser Thr Asn Ser Thr Ile Thr Leu Pro Cys Arg 
385                 390                 395                 400 


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr 
                405                 410                 415     


Ala Ser Pro Ile Ala Gly Glu Ile Thr Cys Lys Ser Asn Ile Thr Gly 
            420                 425                 430         


Leu Leu Leu Thr Arg Asp Gly Gly Gly Asn Asn Ser Thr Glu Glu Thr 
        435                 440                 445             


Phe Arg Pro Gly Gly Gly Asn Met Arg Asp Asn Trp Arg Ser Glu Leu 
    450                 455                 460                 


Tyr Lys Tyr Lys Val Val Glu Val Lys Pro Leu Gly Ile Ala Pro Thr 
465                 470                 475                 480 


Glu Ala Arg Arg Arg Val Val Gln Gln Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Glu Gly Gly Trp Gln Gly Met Val Asp Gly Trp Tyr Gly 
            500                 505                 510         


Tyr His His Ser Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Lys Glu 
        515                 520                 525             


Ser Thr Gln Lys Ala Ile Asp Gly Val Thr Asn Lys Val Asn Ser Ile 
    530                 535                 540                 


Ile Asp Lys Met Asn Thr Gln Phe Glu Ala Val Gly Arg Glu Phe Asn 
545                 550                 555                 560 


Asn Leu Glu Arg Arg Ile Glu Asn Leu Asn Lys Lys Met Glu Asp Gly 
                565                 570                 575     


Phe Leu Asp Val Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Met Glu 
            580                 585                 590         


Asn Glu Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr 
        595                 600                 605             


Asp Lys Val Arg Leu Gln Leu Arg Asp Asn Ala Lys Glu Leu Gly Asn 
    610                 615                 620                 


Gly Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser 
625                 630                 635                 640 


Val Arg Asn Gly Thr Tyr Asp Tyr Pro Gln Tyr Ser Glu Glu Ala Arg 
                645                 650                 655     


Leu Lys Arg Glu Glu Ile Ser Gly Val Lys Leu Glu Ser Ile Gly Ile 
            660                 665                 670         


Tyr Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu 
        675                 680                 685             


Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser 
    690                 695                 700                 


Leu Gln Cys Arg Ala Ala Ala 
705                 710     


<210>  6
<211>  735
<212>  PRT
<213>  Artificial

<220>
<223>  CAP256SU Gp150FL

<400>  6

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Ser Gly Gly Leu Trp Val Thr Val Tyr Tyr Gly Val Pro 
            20                  25                  30          


Val Trp Arg Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
        35                  40                  45              


Ser Tyr Glu Lys Glu Val His Asn Val Trp Ala Thr His Ala Cys Val 
    50                  55                  60                  


Pro Thr Asp Pro Asn Pro Gln Glu Leu Val Leu Lys Asn Val Thr Glu 
65                  70                  75                  80  


Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp 
                85                  90                  95      


Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr 
            100                 105                 110         


Pro Leu Cys Val Thr Leu Asn Cys Ser Asp Ala Lys Val Asn Ile Asn 
        115                 120                 125             


Ala Thr Tyr Asn Gly Thr Arg Glu Glu Ile Lys Asn Cys Ser Phe Asn 
    130                 135                 140                 


Ala Thr Thr Glu Leu Arg Asp Lys Lys Lys Lys Glu Tyr Ala Leu Phe 
145                 150                 155                 160 


Tyr Arg Leu Asp Ile Val Pro Leu Asn Lys Glu Gly Asn Asn Asn Ser 
                165                 170                 175     


Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys 
            180                 185                 190         


Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
        195                 200                 205             


Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly 
    210                 215                 220                 


Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
225                 230                 235                 240 


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu 
                245                 250                 255     


Ile Ile Ile Arg Ser Glu Asn Leu Thr Asp Asn Val Lys Thr Ile Ile 
            260                 265                 270         


Val His Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
        275                 280                 285             


Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala 
    290                 295                 300                 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser 
305                 310                 315                 320 


Glu Ile Lys Trp Glu Lys Thr Leu Gln Arg Val Ser Glu Lys Leu Arg 
                325                 330                 335     


Glu His Phe Asn Lys Thr Ile Ile Phe Asn Gln Ser Ser Gly Gly Asp 
            340                 345                 350         


Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
        355                 360                 365             


Cys Asn Thr Ser Asp Leu Phe Phe Asn Lys Thr Phe Asp Glu Thr Tyr 
    370                 375                 380                 


Ser Thr Gly Ser Asn Ser Thr Asn Ser Thr Ile Thr Leu Pro Cys Arg 
385                 390                 395                 400 


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr 
                405                 410                 415     


Ala Ser Pro Ile Ala Gly Glu Ile Thr Cys Lys Ser Asn Ile Thr Gly 
            420                 425                 430         


Leu Leu Leu Thr Arg Asp Gly Gly Gly Asn Asn Ser Thr Glu Glu Thr 
        435                 440                 445             


Phe Arg Pro Gly Gly Gly Asn Met Arg Asp Asn Trp Arg Ser Glu Leu 
    450                 455                 460                 


Tyr Lys Tyr Lys Val Val Glu Val Lys Pro Leu Gly Ile Ala Pro Thr 
465                 470                 475                 480 


Glu Ala Arg Arg Arg Val Val Gln Gln Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Ala Val Val Gly Leu Gly Ala Val Phe Leu Gly Phe Leu 
            500                 505                 510         


Gly Thr Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
        515                 520                 525             


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
    530                 535                 540                 


Leu Arg Ala Pro Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp 
545                 550                 555                 560 


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu Arg Tyr Leu 
                565                 570                 575     


Lys Asp Gln Gln Leu Leu Gly Met Trp Gly Cys Ser Gly Lys Leu Ile 
            580                 585                 590         


Cys Thr Thr Asn Val Tyr Trp Asn Ser Ser Trp Ser Asn Lys Thr Tyr 
        595                 600                 605             


Asn Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile 
    610                 615                 620                 


Asp Asn Tyr Thr Asp Thr Ile Tyr Lys Leu Leu Glu Val Ser Gln Lys 
625                 630                 635                 640 


Gln Gln Glu Ser Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Asn 
                645                 650                 655     


Asn Leu Trp Asn Trp Phe Asp Ile Ser Lys Trp Leu Trp Tyr Ile Lys 
            660                 665                 670         


Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe 
        675                 680                 685             


Ala Val Leu Ser Leu Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu 
    690                 695                 700                 


Ser Phe Gln Thr Leu Thr Pro Asn Pro Arg Glu Leu Asp Arg Leu Gly 
705                 710                 715                 720 


Gly Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Ala Ala Ala 
                725                 730                 735 


<210>  7
<211>  853
<212>  PRT
<213>  Artificial

<220>
<223>  CAP256SU Gp160FL

<400>  7

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Ser Gly Gly Leu Trp Val Thr Val Tyr Tyr Gly Val Pro 
            20                  25                  30          


Val Trp Arg Glu Ala Lys Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys 
        35                  40                  45              


Ser Tyr Glu Lys Glu Val His Asn Val Trp Ala Thr His Ala Cys Val 
    50                  55                  60                  


Pro Thr Asp Pro Asn Pro Gln Glu Leu Val Leu Lys Asn Val Thr Glu 
65                  70                  75                  80  


Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln Met His Glu Asp 
                85                  90                  95      


Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr 
            100                 105                 110         


Pro Leu Cys Val Thr Leu Asn Cys Ser Asp Ala Lys Val Asn Ile Asn 
        115                 120                 125             


Ala Thr Tyr Asn Gly Thr Arg Glu Glu Ile Lys Asn Cys Ser Phe Asn 
    130                 135                 140                 


Ala Thr Thr Glu Leu Arg Asp Lys Lys Lys Lys Glu Tyr Ala Leu Phe 
145                 150                 155                 160 


Tyr Arg Leu Asp Ile Val Pro Leu Asn Lys Glu Gly Asn Asn Asn Ser 
                165                 170                 175     


Glu Tyr Arg Leu Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys 
            180                 185                 190         


Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
        195                 200                 205             


Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly 
    210                 215                 220                 


Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Lys Pro 
225                 230                 235                 240 


Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu 
                245                 250                 255     


Ile Ile Ile Arg Ser Glu Asn Leu Thr Asp Asn Val Lys Thr Ile Ile 
            260                 265                 270         


Val His Leu Asn Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
        275                 280                 285             


Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe Tyr Ala 
    290                 295                 300                 


Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser 
305                 310                 315                 320 


Glu Ile Lys Trp Glu Lys Thr Leu Gln Arg Val Ser Glu Lys Leu Arg 
                325                 330                 335     


Glu His Phe Asn Lys Thr Ile Ile Phe Asn Gln Ser Ser Gly Gly Asp 
            340                 345                 350         


Leu Glu Ile Thr Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
        355                 360                 365             


Cys Asn Thr Ser Asp Leu Phe Phe Asn Lys Thr Phe Asp Glu Thr Tyr 
    370                 375                 380                 


Ser Thr Gly Ser Asn Ser Thr Asn Ser Thr Ile Thr Leu Pro Cys Arg 
385                 390                 395                 400 


Ile Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Arg Ala Met Tyr 
                405                 410                 415     


Ala Ser Pro Ile Ala Gly Glu Ile Thr Cys Lys Ser Asn Ile Thr Gly 
            420                 425                 430         


Leu Leu Leu Thr Arg Asp Gly Gly Gly Asn Asn Ser Thr Glu Glu Thr 
        435                 440                 445             


Phe Arg Pro Gly Gly Gly Asn Met Arg Asp Asn Trp Arg Ser Glu Leu 
    450                 455                 460                 


Tyr Lys Tyr Lys Val Val Glu Val Lys Pro Leu Gly Ile Ala Pro Thr 
465                 470                 475                 480 


Glu Ala Arg Arg Arg Val Val Gln Gln Gly Gly Gly Gly Ser Gly Gly 
                485                 490                 495     


Gly Gly Ser Ala Val Val Gly Leu Gly Ala Val Phe Leu Gly Phe Leu 
            500                 505                 510         


Gly Thr Ala Gly Ser Thr Met Gly Ala Ala Ser Ile Thr Leu Thr Val 
        515                 520                 525             


Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Ser Asn Leu 
    530                 535                 540                 


Leu Arg Ala Pro Glu Ala Gln Gln His Met Leu Gln Leu Thr Val Trp 
545                 550                 555                 560 


Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Ile Glu Arg Tyr Leu 
                565                 570                 575     


Lys Asp Gln Gln Leu Leu Gly Met Trp Gly Cys Ser Gly Lys Leu Ile 
            580                 585                 590         


Cys Thr Thr Asn Val Tyr Trp Asn Ser Ser Trp Ser Asn Lys Thr Tyr 
        595                 600                 605             


Asn Glu Ile Trp Asp Asn Met Thr Trp Met Gln Trp Asp Arg Glu Ile 
    610                 615                 620                 


Asp Asn Tyr Thr Asp Thr Ile Tyr Lys Leu Leu Glu Val Ser Gln Lys 
625                 630                 635                 640 


Gln Gln Glu Ser Asn Glu Lys Asp Leu Leu Ala Leu Asp Ser Trp Asn 
                645                 650                 655     


Asn Leu Trp Asn Trp Phe Asp Ile Ser Lys Trp Leu Trp Tyr Ile Lys 
            660                 665                 670         


Ile Phe Ile Met Ile Val Gly Gly Leu Ile Gly Leu Arg Ile Ile Phe 
        675                 680                 685             


Ala Val Leu Ser Leu Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu 
    690                 695                 700                 


Ser Phe Gln Thr Leu Thr Pro Asn Pro Arg Glu Leu Asp Arg Leu Gly 
705                 710                 715                 720 


Gly Ile Glu Glu Glu Gly Gly Glu Gln Asp Arg Asp Arg Ser Ile Arg 
                725                 730                 735     


Leu Val Ser Gly Phe Phe Ser Leu Ala Trp Asn Asp Leu Arg Ser Leu 
            740                 745                 750         


Cys Leu Phe Cys Tyr His Arg Leu Arg Asp Phe Ile Leu Ile Ala Gly 
        755                 760                 765             


Arg Ala Val Glu Leu Leu Gly Arg Ser Ser Leu Gln Gly Leu Gln Arg 
    770                 775                 780                 


Gly Trp Glu Ile Leu Lys Tyr Leu Gly Ser Leu Val Gln Tyr Trp Gly 
785                 790                 795                 800 


Leu Glu Leu Lys Lys Ser Ala Ile Asn Leu Phe Asp Thr Ile Ala Ile 
                805                 810                 815     


Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Glu Phe Leu Gln Arg 
            820                 825                 830         


Ile Val Arg Ala Ile Leu His Ile Pro Arg Arg Ile Arg Gln Gly Phe 
        835                 840                 845             


Glu Ala Ala Leu Gln 
    850             


<210>  8
<211>  646
<212>  PRT
<213>  Artificial

<220>
<223>  Du151 Gp140NFL

<400>  8

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Ser Gly Val Gly Asn Leu Asn Leu Trp Val Thr Val Tyr 
            20                  25                  30          


Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala 
        35                  40                  45              


Ser Asp Ala Lys Ala Tyr Asp Lys Glu Val His Asn Val Trp Ala Thr 
    50                  55                  60                  


His Ala Cys Val Pro Thr Asp Pro Asn Pro Arg Glu Ile Val Leu Glu 
65                  70                  75                  80  


Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln 
                85                  90                  95      


Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys 
            100                 105                 110         


Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asn Ala Pro 
        115                 120                 125             


Ala Tyr Asn Asn Ser Met His Gly Glu Met Lys Asn Cys Ser Phe Asn 
    130                 135                 140                 


Thr Thr Thr Glu Ile Arg Asp Arg Lys Gln Lys Ala Tyr Ala Leu Phe 
145                 150                 155                 160 


Tyr Lys Pro Asp Val Val Pro Leu Asn Arg Arg Glu Glu Asn Asn Gly 
                165                 170                 175     


Thr Gly Glu Tyr Ile Leu Ile Asn Cys Asn Ser Ser Thr Ile Thr Gln 
            180                 185                 190         


Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala 
        195                 200                 205             


Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
    210                 215                 220                 


Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
225                 230                 235                 240 


Met Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
                245                 250                 255     


Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ile Lys Thr 
            260                 265                 270         


Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Val Cys Thr Arg Pro 
        275                 280                 285             


Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe 
    290                 295                 300                 


Tyr Ala Thr Gly Glu Ile Ile Gly Asn Ile Arg Glu Ala His Cys Asn 
305                 310                 315                 320 


Ile Ser Lys Ser Asn Trp Thr Ser Thr Leu Glu Gln Val Lys Lys Lys 
                325                 330                 335     


Leu Lys Glu His Tyr Asn Lys Thr Ile Glu Phe Asn Pro Pro Ser Gly 
            340                 345                 350         


Gly Asp Leu Glu Val Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe 
        355                 360                 365             


Phe Tyr Cys Asn Thr Thr Lys Leu Phe Ser Asn Asn Ser Asp Ser Asn 
    370                 375                 380                 


Asn Glu Thr Ile Thr Leu Pro Cys Lys Ile Lys Gln Ile Ile Asn Met 
385                 390                 395                 400 


Trp Gln Lys Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Glu Gly Asn 
                405                 410                 415     


Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
            420                 425                 430         


Gly Lys Asn Thr Thr Asn Glu Ile Phe Arg Pro Gly Gly Gly Asn Met 
        435                 440                 445             


Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile 
    450                 455                 460                 


Glu Pro Leu Gly Val Ala Pro Thr Lys Ser Lys Arg Arg Val Val Glu 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Val Gly Leu Gly Ala 
                485                 490                 495     


Val Leu Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
            500                 505                 510         


Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val 
        515                 520                 525             


Gln Gln Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Met 
    530                 535                 540                 


Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu 
545                 550                 555                 560 


Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly 
                565                 570                 575     


Cys Ser Gly Lys Ile Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser 
            580                 585                 590         


Trp Ser Asn Lys Ser Gln Glu Asp Ile Trp Asp Asn Met Thr Trp Met 
        595                 600                 605             


Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Gly Thr Ile Tyr Arg Leu 
    610                 615                 620                 


Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu 
625                 630                 635                 640 


Ala Leu Asp Ala Ala Ala 
                645     


<210>  9
<211>  699
<212>  PRT
<213>  Artificial

<220>
<223>  Du151 Gp140FL fused to truncated HA2 of influenza

<400>  9

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Ser Gly Val Gly Asn Leu Asn Leu Trp Val Thr Val Tyr 
            20                  25                  30          


Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala 
        35                  40                  45              


Ser Asp Ala Lys Ala Tyr Asp Lys Glu Val His Asn Val Trp Ala Thr 
    50                  55                  60                  


His Ala Cys Val Pro Thr Asp Pro Asn Pro Arg Glu Ile Val Leu Glu 
65                  70                  75                  80  


Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln 
                85                  90                  95      


Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys 
            100                 105                 110         


Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asn Ala Pro 
        115                 120                 125             


Ala Tyr Asn Asn Ser Met His Gly Glu Met Lys Asn Cys Ser Phe Asn 
    130                 135                 140                 


Thr Thr Thr Glu Ile Arg Asp Arg Lys Gln Lys Ala Tyr Ala Leu Phe 
145                 150                 155                 160 


Tyr Lys Pro Asp Val Val Pro Leu Asn Arg Arg Glu Glu Asn Asn Gly 
                165                 170                 175     


Thr Gly Glu Tyr Ile Leu Ile Asn Cys Asn Ser Ser Thr Ile Thr Gln 
            180                 185                 190         


Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala 
        195                 200                 205             


Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
    210                 215                 220                 


Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
225                 230                 235                 240 


Met Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
                245                 250                 255     


Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ile Lys Thr 
            260                 265                 270         


Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Val Cys Thr Arg Pro 
        275                 280                 285             


Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe 
    290                 295                 300                 


Tyr Ala Thr Gly Glu Ile Ile Gly Asn Ile Arg Glu Ala His Cys Asn 
305                 310                 315                 320 


Ile Ser Lys Ser Asn Trp Thr Ser Thr Leu Glu Gln Val Lys Lys Lys 
                325                 330                 335     


Leu Lys Glu His Tyr Asn Lys Thr Ile Glu Phe Asn Pro Pro Ser Gly 
            340                 345                 350         


Gly Asp Leu Glu Val Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe 
        355                 360                 365             


Phe Tyr Cys Asn Thr Thr Lys Leu Phe Ser Asn Asn Ser Asp Ser Asn 
    370                 375                 380                 


Asn Glu Thr Ile Thr Leu Pro Cys Lys Ile Lys Gln Ile Ile Asn Met 
385                 390                 395                 400 


Trp Gln Lys Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Glu Gly Asn 
                405                 410                 415     


Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
            420                 425                 430         


Gly Lys Asn Thr Thr Asn Glu Ile Phe Arg Pro Gly Gly Gly Asn Met 
        435                 440                 445             


Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile 
    450                 455                 460                 


Glu Pro Leu Gly Val Ala Pro Thr Lys Ser Lys Arg Arg Val Val Glu 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Val Gly Leu Gly Ala 
                485                 490                 495     


Val Leu Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
            500                 505                 510         


Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val 
        515                 520                 525             


Gln Gln Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Met 
    530                 535                 540                 


Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu 
545                 550                 555                 560 


Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly 
                565                 570                 575     


Cys Ser Gly Lys Ile Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser 
            580                 585                 590         


Trp Ser Asn Lys Ser Gln Glu Asp Ile Trp Asp Asn Met Thr Trp Met 
        595                 600                 605             


Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Gly Thr Ile Tyr Arg Leu 
    610                 615                 620                 


Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu 
625                 630                 635                 640 


Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn Trp Phe Asn Ile Thr Asn 
                645                 650                 655     


Trp Leu Trp Tyr Ile Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser 
            660                 665                 670         


Ser Leu Ala Leu Ala Ile Met Val Ala Gly Leu Ser Leu Trp Met Cys 
        675                 680                 685             


Ser Asn Gly Ser Leu Gln Cys Arg Ala Ala Ala 
    690                 695                 


<210>  10
<211>  702
<212>  PRT
<213>  Artificial

<220>
<223>  Du151 Gp120FL fused to HA2 of influenza

<400>  10

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Ser Gly Val Gly Asn Leu Asn Leu Trp Val Thr Val Tyr 
            20                  25                  30          


Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala 
        35                  40                  45              


Ser Asp Ala Lys Ala Tyr Asp Lys Glu Val His Asn Val Trp Ala Thr 
    50                  55                  60                  


His Ala Cys Val Pro Thr Asp Pro Asn Pro Arg Glu Ile Val Leu Glu 
65                  70                  75                  80  


Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln 
                85                  90                  95      


Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys 
            100                 105                 110         


Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asn Ala Pro 
        115                 120                 125             


Ala Tyr Asn Asn Ser Met His Gly Glu Met Lys Asn Cys Ser Phe Asn 
    130                 135                 140                 


Thr Thr Thr Glu Ile Arg Asp Arg Lys Gln Lys Ala Tyr Ala Leu Phe 
145                 150                 155                 160 


Tyr Lys Pro Asp Val Val Pro Leu Asn Arg Arg Glu Glu Asn Asn Gly 
                165                 170                 175     


Thr Gly Glu Tyr Ile Leu Ile Asn Cys Asn Ser Ser Thr Ile Thr Gln 
            180                 185                 190         


Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala 
        195                 200                 205             


Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
    210                 215                 220                 


Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
225                 230                 235                 240 


Met Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
                245                 250                 255     


Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ile Lys Thr 
            260                 265                 270         


Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Val Cys Thr Arg Pro 
        275                 280                 285             


Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe 
    290                 295                 300                 


Tyr Ala Thr Gly Glu Ile Ile Gly Asn Ile Arg Glu Ala His Cys Asn 
305                 310                 315                 320 


Ile Ser Lys Ser Asn Trp Thr Ser Thr Leu Glu Gln Val Lys Lys Lys 
                325                 330                 335     


Leu Lys Glu His Tyr Asn Lys Thr Ile Glu Phe Asn Pro Pro Ser Gly 
            340                 345                 350         


Gly Asp Leu Glu Val Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe 
        355                 360                 365             


Phe Tyr Cys Asn Thr Thr Lys Leu Phe Ser Asn Asn Ser Asp Ser Asn 
    370                 375                 380                 


Asn Glu Thr Ile Thr Leu Pro Cys Lys Ile Lys Gln Ile Ile Asn Met 
385                 390                 395                 400 


Trp Gln Lys Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Glu Gly Asn 
                405                 410                 415     


Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
            420                 425                 430         


Gly Lys Asn Thr Thr Asn Glu Ile Phe Arg Pro Gly Gly Gly Asn Met 
        435                 440                 445             


Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile 
    450                 455                 460                 


Glu Pro Leu Gly Val Ala Pro Thr Lys Ser Lys Arg Arg Val Val Glu 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Gly Gly Trp Gln Gly 
                485                 490                 495     


Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln Gly Ser 
            500                 505                 510         


Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp Gly Val 
        515                 520                 525             


Thr Asn Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln Phe Glu 
    530                 535                 540                 


Ala Val Gly Arg Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu Asn Leu 
545                 550                 555                 560 


Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr Asn Ala 
                565                 570                 575     


Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe His Asp 
            580                 585                 590         


Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu Arg Asp 
        595                 600                 605             


Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys 
    610                 615                 620                 


Asp Asn Glu Cys Met Glu Ser Val Arg Asn Gly Thr Tyr Asp Tyr Pro 
625                 630                 635                 640 


Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg Glu Glu Ile Ser Gly Val 
                645                 650                 655     


Lys Leu Glu Ser Ile Gly Ile Tyr Gln Ile Leu Ser Ile Tyr Ser Thr 
            660                 665                 670         


Val Ala Ser Ser Leu Ala Leu Ala Ile Met Val Ala Gly Leu Ser Leu 
        675                 680                 685             


Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ala Ala Ala 
    690                 695                 700         


<210>  11
<211>  725
<212>  PRT
<213>  Artificial

<220>
<223>  Du151 Gp150FL

<400>  11

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Ser Gly Val Gly Asn Leu Asn Leu Trp Val Thr Val Tyr 
            20                  25                  30          


Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala 
        35                  40                  45              


Ser Asp Ala Lys Ala Tyr Asp Lys Glu Val His Asn Val Trp Ala Thr 
    50                  55                  60                  


His Ala Cys Val Pro Thr Asp Pro Asn Pro Arg Glu Ile Val Leu Glu 
65                  70                  75                  80  


Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln 
                85                  90                  95      


Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys 
            100                 105                 110         


Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asn Ala Pro 
        115                 120                 125             


Ala Tyr Asn Asn Ser Met His Gly Glu Met Lys Asn Cys Ser Phe Asn 
    130                 135                 140                 


Thr Thr Thr Glu Ile Arg Asp Arg Lys Gln Lys Ala Tyr Ala Leu Phe 
145                 150                 155                 160 


Tyr Lys Pro Asp Val Val Pro Leu Asn Arg Arg Glu Glu Asn Asn Gly 
                165                 170                 175     


Thr Gly Glu Tyr Ile Leu Ile Asn Cys Asn Ser Ser Thr Ile Thr Gln 
            180                 185                 190         


Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala 
        195                 200                 205             


Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
    210                 215                 220                 


Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
225                 230                 235                 240 


Met Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
                245                 250                 255     


Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ile Lys Thr 
            260                 265                 270         


Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Val Cys Thr Arg Pro 
        275                 280                 285             


Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe 
    290                 295                 300                 


Tyr Ala Thr Gly Glu Ile Ile Gly Asn Ile Arg Glu Ala His Cys Asn 
305                 310                 315                 320 


Ile Ser Lys Ser Asn Trp Thr Ser Thr Leu Glu Gln Val Lys Lys Lys 
                325                 330                 335     


Leu Lys Glu His Tyr Asn Lys Thr Ile Glu Phe Asn Pro Pro Ser Gly 
            340                 345                 350         


Gly Asp Leu Glu Val Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe 
        355                 360                 365             


Phe Tyr Cys Asn Thr Thr Lys Leu Phe Ser Asn Asn Ser Asp Ser Asn 
    370                 375                 380                 


Asn Glu Thr Ile Thr Leu Pro Cys Lys Ile Lys Gln Ile Ile Asn Met 
385                 390                 395                 400 


Trp Gln Lys Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Glu Gly Asn 
                405                 410                 415     


Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
            420                 425                 430         


Gly Lys Asn Thr Thr Asn Glu Ile Phe Arg Pro Gly Gly Gly Asn Met 
        435                 440                 445             


Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile 
    450                 455                 460                 


Glu Pro Leu Gly Val Ala Pro Thr Lys Ser Lys Arg Arg Val Val Glu 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Val Gly Leu Gly Ala 
                485                 490                 495     


Val Leu Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
            500                 505                 510         


Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val 
        515                 520                 525             


Gln Gln Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Met 
    530                 535                 540                 


Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu 
545                 550                 555                 560 


Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly 
                565                 570                 575     


Cys Ser Gly Lys Ile Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser 
            580                 585                 590         


Trp Ser Asn Lys Ser Gln Glu Asp Ile Trp Asp Asn Met Thr Trp Met 
        595                 600                 605             


Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Gly Thr Ile Tyr Arg Leu 
    610                 615                 620                 


Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu 
625                 630                 635                 640 


Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn Trp Phe Asn Ile Thr Asn 
                645                 650                 655     


Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile 
            660                 665                 670         


Gly Leu Arg Ile Ile Phe Gly Val Leu Ala Ile Val Lys Arg Val Arg 
        675                 680                 685             


Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro Ser Pro Arg 
    690                 695                 700                 


Gly Pro Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp 
705                 710                 715                 720 


Lys Asp Ala Ala Ala 
                725 


<210>  12
<211>  842
<212>  PRT
<213>  Artificial

<220>
<223>  Du151 Gp160FL

<400>  12

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Ser Gly Val Gly Asn Leu Asn Leu Trp Val Thr Val Tyr 
            20                  25                  30          


Tyr Gly Val Pro Val Trp Lys Glu Ala Lys Thr Thr Leu Phe Cys Ala 
        35                  40                  45              


Ser Asp Ala Lys Ala Tyr Asp Lys Glu Val His Asn Val Trp Ala Thr 
    50                  55                  60                  


His Ala Cys Val Pro Thr Asp Pro Asn Pro Arg Glu Ile Val Leu Glu 
65                  70                  75                  80  


Asn Val Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Asp Gln 
                85                  90                  95      


Met His Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys 
            100                 105                 110         


Val Lys Leu Thr Pro Leu Cys Val Thr Leu Asn Cys Thr Asn Ala Pro 
        115                 120                 125             


Ala Tyr Asn Asn Ser Met His Gly Glu Met Lys Asn Cys Ser Phe Asn 
    130                 135                 140                 


Thr Thr Thr Glu Ile Arg Asp Arg Lys Gln Lys Ala Tyr Ala Leu Phe 
145                 150                 155                 160 


Tyr Lys Pro Asp Val Val Pro Leu Asn Arg Arg Glu Glu Asn Asn Gly 
                165                 170                 175     


Thr Gly Glu Tyr Ile Leu Ile Asn Cys Asn Ser Ser Thr Ile Thr Gln 
            180                 185                 190         


Ala Cys Pro Lys Val Thr Phe Asp Pro Ile Pro Ile His Tyr Cys Ala 
        195                 200                 205             


Pro Ala Gly Tyr Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly 
    210                 215                 220                 


Thr Gly Pro Cys Asn Asn Val Ser Thr Val Gln Cys Thr His Gly Ile 
225                 230                 235                 240 


Met Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu 
                245                 250                 255     


Glu Glu Ile Ile Ile Arg Ser Glu Asn Leu Thr Asn Asn Ile Lys Thr 
            260                 265                 270         


Ile Ile Val His Leu Asn Lys Ser Val Glu Ile Val Cys Thr Arg Pro 
        275                 280                 285             


Asn Asn Asn Thr Arg Lys Ser Ile Arg Ile Gly Pro Gly Gln Thr Phe 
    290                 295                 300                 


Tyr Ala Thr Gly Glu Ile Ile Gly Asn Ile Arg Glu Ala His Cys Asn 
305                 310                 315                 320 


Ile Ser Lys Ser Asn Trp Thr Ser Thr Leu Glu Gln Val Lys Lys Lys 
                325                 330                 335     


Leu Lys Glu His Tyr Asn Lys Thr Ile Glu Phe Asn Pro Pro Ser Gly 
            340                 345                 350         


Gly Asp Leu Glu Val Thr Thr His Ser Phe Asn Cys Arg Gly Glu Phe 
        355                 360                 365             


Phe Tyr Cys Asn Thr Thr Lys Leu Phe Ser Asn Asn Ser Asp Ser Asn 
    370                 375                 380                 


Asn Glu Thr Ile Thr Leu Pro Cys Lys Ile Lys Gln Ile Ile Asn Met 
385                 390                 395                 400 


Trp Gln Lys Val Gly Arg Ala Met Tyr Ala Pro Pro Ile Glu Gly Asn 
                405                 410                 415     


Ile Thr Cys Lys Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
            420                 425                 430         


Gly Lys Asn Thr Thr Asn Glu Ile Phe Arg Pro Gly Gly Gly Asn Met 
        435                 440                 445             


Lys Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Glu Ile 
    450                 455                 460                 


Glu Pro Leu Gly Val Ala Pro Thr Lys Ser Lys Arg Arg Val Val Glu 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Val Gly Leu Gly Ala 
                485                 490                 495     


Val Leu Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Ala 
            500                 505                 510         


Ser Ile Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val 
        515                 520                 525             


Gln Gln Gln Ser Asn Leu Leu Arg Ala Pro Glu Ala Gln Gln His Met 
    530                 535                 540                 


Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Thr Arg Val Leu 
545                 550                 555                 560 


Ala Ile Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Leu Trp Gly 
                565                 570                 575     


Cys Ser Gly Lys Ile Ile Cys Thr Thr Ala Val Pro Trp Asn Ser Ser 
            580                 585                 590         


Trp Ser Asn Lys Ser Gln Glu Asp Ile Trp Asp Asn Met Thr Trp Met 
        595                 600                 605             


Gln Trp Asp Arg Glu Ile Ser Asn Tyr Thr Gly Thr Ile Tyr Arg Leu 
    610                 615                 620                 


Leu Glu Asp Ser Gln Asn Gln Gln Glu Lys Asn Glu Lys Asp Leu Leu 
625                 630                 635                 640 


Ala Leu Asp Ser Trp Lys Asn Leu Trp Asn Trp Phe Asn Ile Thr Asn 
                645                 650                 655     


Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Ile 
            660                 665                 670         


Gly Leu Arg Ile Ile Phe Gly Val Leu Ala Ile Val Lys Arg Val Arg 
        675                 680                 685             


Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Leu Thr Pro Ser Pro Arg 
    690                 695                 700                 


Gly Pro Asp Arg Leu Gly Arg Ile Glu Glu Glu Gly Gly Glu Gln Asp 
705                 710                 715                 720 


Lys Asp Arg Ser Ile Arg Leu Val Ser Gly Phe Leu Ala Leu Ala Trp 
                725                 730                 735     


Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His His Leu Arg Asp 
            740                 745                 750         


Phe Ile Leu Ile Ala Ala Arg Ala Ala Glu Leu Leu Gly Arg Ser Ser 
        755                 760                 765             


Leu Arg Gly Leu Gln Arg Gly Trp Glu Ala Leu Lys Tyr Leu Gly Asn 
    770                 775                 780                 


Leu Val Gln Tyr Gly Gly Leu Glu Leu Lys Arg Ser Ala Ile Lys Leu 
785                 790                 795                 800 


Phe Asp Thr Ile Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Ile Leu 
                805                 810                 815     


Glu Val Ile Gln Arg Ile Cys Arg Ala Ile Arg His Ile Pro Ile Arg 
            820                 825                 830         


Ile Arg Gln Gly Phe Glu Ala Ala Leu Gln 
        835                 840         


<210>  13
<211>  1971
<212>  DNA
<213>  Artificial

<220>
<223>  CAP256SU Gp140NFL

<400>  13
atggagtggt cttggatctt cctgtttctg ctgagcggga ctgctggagt gcattcttcc       60

ggagggctgt gggtcactgt ctactatggc gtgcctgtct ggagagaggc caagaccaca      120

ctgttctgcg cttccgatgc aaagtcttac gaaaaagagg tgcacaacgt ctgggccaca      180

catgcttgcg tgccaactga ccccaaccct caggaactgg tgctgaagaa tgtcaccgag      240

aactttaata tgtggaaaaa tgacatggtg gatcagatgc acgaggatat cattagtctg      300

tgggaccagt cactgaagcc ctgcgtgaaa ctgacacctc tgtgcgtcac tctgaactgt      360

agcgatgcaa aggtgaacat taatgccaca tacaatggca ctcgcgagga aatcaaaaac      420

tgttccttca atgcaactac cgaactgagg gacaagaaga agaaggagta cgccctgttt      480

tatcgcctgg acatcgtgcc cctgaacaag gaagggaaca ataacagtga gtatcggctg      540

attaactgca ataccagcgt gattacccag gcctgtccta aagtcacctt cgatccaatt      600

cccatccact actgcgcacc agccggatat gctattctga agtgtaacaa caaaactttt      660

aacgggaccg gaccctgcaa taacgtgtct acagtccagt gtactcatgg catcaagcct      720

gtggtctcaa cccagctgct gctgaatggg agcctggccg aggaagagat cattatcaga      780

agcgagaacc tgaccgacaa tgtgaagaca attatcgtcc acctgaacga atccgtggag      840

attaattgca ccaggccaaa caacaacaca cgaaaatcta ttcggatcgg accaggacag      900

accttctacg caacagggga cattatcgga gatatcaggc aggctcattg taacatttct      960

gaaatcaagt gggagaaaac cctgcagcgc gtgagtgaaa agctgcgaga gcacttcaac     1020

aaaacaatca tctttaatca gagctccggc ggggacctgg aaatcacaac tcattcattc     1080

aactgcggag gcgagttctt ttactgtaac actagcgatc tgttctttaa taagaccttt     1140

gacgagacct attccacagg ctcaaacagc actaattcta ccattacact gccatgccga     1200

atcaaacaga ttatcaacat gtggcaggaa gtgggccggg caatgtatgc cagccccatt     1260

gccggagaga tcacctgtaa gtccaatatc actggactgc tgctgaccag agatggggga     1320

ggcaacaatt ctactgaaga gacctttagg cccgggggag gcaacatgag agacaattgg     1380

aggagcgaac tgtacaagta taaagtggtc gaggtgaagc ctctgggaat cgcaccaacc     1440

gaggcccgga gaagggtggt ccagcagggc ggtggaggct caggtggagg cggatccgct     1500

gtggtcggac tgggagcagt gttcctgggg tttctgggaa ctgctggcag caccatggga     1560

gccgcttcca ttactctgac cgtgcaggca cgccagctgc tgtctggcat cgtccagcag     1620

cagagtaacc tgctgcgggc tcctgaagca cagcagcata tgctgcagct gaccgtgtgg     1680

gggattaagc agctgcaggc ccgggtcctg gctatcgaga gatacctgaa ggatcagcag     1740

ctgctgggga tgtggggatg cagtggcaaa ctgatttgca ccacaaacgt gtactggaac     1800

agcagctggt ccaacaagac atataatgaa atctgggaca acatgacttg gatgcagtgg     1860

gaccgcgaga tcgataacta cacagacact atctataaac tgctggaagt ctcacagaaa     1920

cagcaggagt caaatgaaaa ggacctgctg gcactggatg cggccgcatg a              1971


<210>  14
<211>  2073
<212>  DNA
<213>  Artificial

<220>
<223>  CAP256SU Gp140FL fused to HA2 of influenza

<400>  14
atggagtggt cttggatctt cctgtttctg ctgagcggga ctgctggagt gcattcttcc       60

ggagggctgt gggtcactgt ctactatggc gtgcctgtct ggagagaggc caagaccaca      120

ctgttctgcg cttccgatgc aaagtcttac gaaaaagagg tgcacaacgt ctgggccaca      180

catgcttgcg tgccaactga ccccaaccct caggaactgg tgctgaagaa tgtcaccgag      240

aactttaata tgtggaaaaa tgacatggtg gatcagatgc acgaggatat cattagtctg      300

tgggaccagt cactgaagcc ctgcgtgaaa ctgacacctc tgtgcgtcac tctgaactgt      360

agcgatgcaa aggtgaacat taatgccaca tacaatggca ctcgcgagga aatcaaaaac      420

tgttccttca atgcaactac cgaactgagg gacaagaaga agaaggagta cgccctgttt      480

tatcgcctgg acatcgtgcc cctgaacaag gaagggaaca ataacagtga gtatcggctg      540

attaactgca ataccagcgt gattacccag gcctgtccta aagtcacctt cgatccaatt      600

cccatccact actgcgcacc agccggatat gctattctga agtgtaacaa caaaactttt      660

aacgggaccg gaccctgcaa taacgtgtct acagtccagt gtactcatgg catcaagcct      720

gtggtctcaa cccagctgct gctgaatggg agcctggccg aggaagagat cattatcaga      780

agcgagaacc tgaccgacaa tgtgaagaca attatcgtcc acctgaacga atccgtggag      840

attaattgca ccaggccaaa caacaacaca cgaaaatcta ttcggatcgg accaggacag      900

accttctacg caacagggga cattatcgga gatatcaggc aggctcattg taacatttct      960

gaaatcaagt gggagaaaac cctgcagcgc gtgagtgaaa agctgcgaga gcacttcaac     1020

aaaacaatca tctttaatca gagctccggc ggggacctgg aaatcacaac tcattcattc     1080

aactgcggag gcgagttctt ttactgtaac actagcgatc tgttctttaa taagaccttt     1140

gacgagacct attccacagg ctcaaacagc actaattcta ccattacact gccatgccga     1200

atcaaacaga ttatcaacat gtggcaggaa gtgggccggg caatgtatgc cagccccatt     1260

gccggagaga tcacctgtaa gtccaatatc actggactgc tgctgaccag agatggggga     1320

ggcaacaatt ctactgaaga gacctttagg cccgggggag gcaacatgag agacaattgg     1380

aggagcgaac tgtacaagta taaagtggtc gaggtgaagc ctctgggaat cgcaccaacc     1440

gaggcccgga gaagggtggt ccagcagggc ggtggaggct caggtggagg cggatccgct     1500

gtggtcggac tgggagcagt gttcctgggg tttctgggaa ctgctggcag caccatggga     1560

gccgcttcca ttactctgac cgtgcaggca cgccagctgc tgtctggcat cgtccagcag     1620

cagagtaacc tgctgcgggc tcctgaagca cagcagcata tgctgcagct gaccgtgtgg     1680

gggattaagc agctgcaggc ccgggtcctg gctatcgaga gatacctgaa ggatcagcag     1740

ctgctgggga tgtggggatg cagtggcaaa ctgatttgca ccacaaacgt gtactggaac     1800

agcagctggt ccaacaagac atataatgaa atctgggaca acatgacttg gatgcagtgg     1860

gaccgcgaga tcgataacta cacagacact atctataaac tgctggaagt ctcacagaaa     1920

cagcaggagt caaatgaaaa ggacctgctg gcactggata gctggaacaa tctgtggaat     1980

tggttcgata tttccaagtg gctgtggtac attcagatcc tgagtatcta ttcaaccgtg     2040

gcttcaagcc tggctctggc aattatggtc gca                                  2073


<210>  15
<211>  2136
<212>  DNA
<213>  Artificial

<220>
<223>  CAP256SU Gp120FL fused to HA2 of influenza

<400>  15
atggagtggt cttggatctt cctgtttctg ctgagcggga ctgctggagt gcattcttcc       60

ggagggctgt gggtcactgt ctactatggc gtgcctgtct ggagagaggc caagaccaca      120

ctgttctgcg cttccgatgc aaagtcttac gaaaaagagg tgcacaacgt ctgggccaca      180

catgcttgcg tgccaactga ccccaaccct caggaactgg tgctgaagaa tgtcaccgag      240

aactttaata tgtggaaaaa tgacatggtg gatcagatgc acgaggatat cattagtctg      300

tgggaccagt cactgaagcc ctgcgtgaaa ctgacacctc tgtgcgtcac tctgaactgt      360

agcgatgcaa aggtgaacat taatgccaca tacaatggca ctcgcgagga aatcaaaaac      420

tgttccttca atgcaactac cgaactgagg gacaagaaga agaaggagta cgccctgttt      480

tatcgcctgg acatcgtgcc cctgaacaag gaagggaaca ataacagtga gtatcggctg      540

attaactgca ataccagcgt gattacccag gcctgtccta aagtcacctt cgatccaatt      600

cccatccact actgcgcacc agccggatat gctattctga agtgtaacaa caaaactttt      660

aacgggaccg gaccctgcaa taacgtgtct acagtccagt gtactcatgg catcaagcct      720

gtggtctcaa cccagctgct gctgaatggg agcctggccg aggaagagat cattatcaga      780

agcgagaacc tgaccgacaa tgtgaagaca attatcgtcc acctgaacga atccgtggag      840

attaattgca ccaggccaaa caacaacaca cgaaaatcta ttcggatcgg accaggacag      900

accttctacg caacagggga cattatcgga gatatcaggc aggctcattg taacatttct      960

gaaatcaagt gggagaaaac cctgcagcgc gtgagtgaaa agctgcgaga gcacttcaac     1020

aaaacaatca tctttaatca gagctccggc ggggacctgg aaatcacaac tcattcattc     1080

aactgcggag gcgagttctt ttactgtaac actagcgatc tgttctttaa taagaccttt     1140

gacgagacct attccacagg ctcaaacagc actaattcta ccattacact gccatgccga     1200

atcaaacaga ttatcaacat gtggcaggaa gtgggccggg caatgtatgc cagccccatt     1260

gccggagaga tcacctgtaa gtccaatatc actggactgc tgctgaccag agatggggga     1320

ggcaacaatt ctactgaaga gacctttagg cccgggggag gcaacatgag agacaattgg     1380

aggagcgaac tgtacaagta taaagtggtc gaggtgaagc ctctgggaat cgcaccaacc     1440

gaggcccgga gaagggtggt ccagcagggc ggtggaggct caggtggagg cggatccgag     1500

gggggatggc agggaatggt ggacgggtgg tacggatatc accattcaaa cgaacagggg     1560

agcggatatg ccgctgacaa ggagtctaca cagaaagcaa tcgatggggt gactaacaag     1620

gtcaatagta tcatcgataa gatgaatacc cagttcgaag ccgtgggacg cgagtttaac     1680

aatctggaac gccgaatcga gaacctgaat aagaaaatgg aagacggctt cctggatgtg     1740

tggacctaca acgctgagct gctggtcctg atggaaaatg agcggacact ggactttcac     1800

gatagcaacg tgaagaatct gtatgacaaa gtcagactgc agctgaggga taacgccaag     1860

gaactgggca atgggtgctt cgagttttac cataaatgcg acaacgaatg tatggagagt     1920

gtgcgcaatg gcacctacga ttatcctcag tattcagaag aggcccggct gaagagagaa     1980

gagattagcg gcgtgaaact ggagtctatt ggcatctacc agatcctgag tatctattca     2040

accgtggctt caagcctggc tctggcaatt atggtcgcag gcctgtctct gtggatgtgc     2100

agcaacgggt ccctgcagtg tcgagcggcc gcatga                               2136


<210>  16
<211>  2208
<212>  DNA
<213>  Artificial

<220>
<223>  CAP256SU Gp150FL

<400>  16
atggagtggt cttggatctt cctgtttctg ctgagcggga ctgctggagt gcattcttcc       60

ggagggctgt gggtcactgt ctactatggc gtgcctgtct ggagagaggc caagaccaca      120

ctgttctgcg cttccgatgc aaagtcttac gaaaaagagg tgcacaacgt ctgggccaca      180

catgcttgcg tgccaactga ccccaaccct caggaactgg tgctgaagaa tgtcaccgag      240

aactttaata tgtggaaaaa tgacatggtg gatcagatgc acgaggatat cattagtctg      300

tgggaccagt cactgaagcc ctgcgtgaaa ctgacacctc tgtgcgtcac tctgaactgt      360

agcgatgcaa aggtgaacat taatgccaca tacaatggca ctcgcgagga aatcaaaaac      420

tgttccttca atgcaactac cgaactgagg gacaagaaga agaaggagta cgccctgttt      480

tatcgcctgg acatcgtgcc cctgaacaag gaagggaaca ataacagtga gtatcggctg      540

attaactgca ataccagcgt gattacccag gcctgtccta aagtcacctt cgatccaatt      600

cccatccact actgcgcacc agccggatat gctattctga agtgtaacaa caaaactttt      660

aacgggaccg gaccctgcaa taacgtgtct acagtccagt gtactcatgg catcaagcct      720

gtggtctcaa cccagctgct gctgaatggg agcctggccg aggaagagat cattatcaga      780

agcgagaacc tgaccgacaa tgtgaagaca attatcgtcc acctgaacga atccgtggag      840

attaattgca ccaggccaaa caacaacaca cgaaaatcta ttcggatcgg accaggacag      900

accttctacg caacagggga cattatcgga gatatcaggc aggctcattg taacatttct      960

gaaatcaagt gggagaaaac cctgcagcgc gtgagtgaaa agctgcgaga gcacttcaac     1020

aaaacaatca tctttaatca gagctccggc ggggacctgg aaatcacaac tcattcattc     1080

aactgcggag gcgagttctt ttactgtaac actagcgatc tgttctttaa taagaccttt     1140

gacgagacct attccacagg ctcaaacagc actaattcta ccattacact gccatgccga     1200

atcaaacaga ttatcaacat gtggcaggaa gtgggccggg caatgtatgc cagccccatt     1260

gccggagaga tcacctgtaa gtccaatatc actggactgc tgctgaccag agatggggga     1320

ggcaacaatt ctactgaaga gacctttagg cccgggggag gcaacatgag agacaattgg     1380

aggagcgaac tgtacaagta taaagtggtc gaggtgaagc ctctgggaat cgcaccaacc     1440

gaggcccgga gaagggtggt ccagcagggc ggtggaggct caggtggagg cggatccgct     1500

gtggtcggac tgggagcagt gttcctgggg tttctgggaa ctgctggcag caccatggga     1560

gccgcttcca ttactctgac cgtgcaggca cgccagctgc tgtctggcat cgtccagcag     1620

cagagtaacc tgctgcgggc tcctgaagca cagcagcata tgctgcagct gaccgtgtgg     1680

gggattaagc agctgcaggc ccgggtcctg gctatcgaga gatacctgaa ggatcagcag     1740

ctgctgggga tgtggggatg cagtggcaaa ctgatttgca ccacaaacgt gtactggaac     1800

agcagctggt ccaacaagac atataatgaa atctgggaca acatgacttg gatgcagtgg     1860

gaccgcgaga tcgataacta cacagacact atctataaac tgctggaagt ctcacagaaa     1920

cagcaggagt caaatgaaaa ggacctgctg gcactggata gctggaacaa tctgtggaat     1980

tggttcgata tttccaagtg gctgtggtac attaagatct tcatcatgat cgtgggggga     2040

ctgatcgggc tgcgcattat cttcgcagtg ctgagcctgg tgaaccgcgt ccgacaggga     2100

tattcccccc tgtcttttca gactctgacc cctaatccac gagaactgga ccggctgggc     2160

gggatcgaag aggaaggagg cgagcaggac cgggatgcgg ccgcatga                  2208


<210>  17
<211>  1941
<212>  DNA
<213>  Artificial

<220>
<223>  Du151 Gp140NFL

<400>  17
atggagtggt cttggatctt cctgttcctg ctgtctggga ctgctggagt gcatagttcc       60

ggagtcggca acctgaatct gtgggtgacc gtgtactatg gcgtgcccgt ctggaaagaa      120

gcaaagacca cactgttttg cgccagcgac gctaaagcat acgataagga ggtgcacaat      180

gtctgggcca cacatgcttg tgtgcctact gaccctaatc cacgggagat cgtgctggaa      240

aacgtcactg agaatttcaa catgtggaag aacgacatgg tggatcagat gcacgaggac      300

atcatttctc tgtgggatca gagtctgaaa ccatgcgtga agctgacccc cctgtgcgtc      360

acactgaatt gtactaacgc ccctgcttac aacaatagca tgcatgggga aatgaagaac      420

tgttccttta acactaccac agagatccga gaccggaaac agaaggcata cgccctgttc      480

tataagcctg atgtggtccc actgaaccgg agagaggaaa acaatggaac aggcgagtat      540

attctgatta actgcaacag ctccacaatt actcaggcct gtccaaaagt gacttttgat      600

cccattccta tccactactg cgctcccgca ggctatgcta tcctgaaatg taacaataag      660

accttcaatg ggacaggacc ttgcaacaat gtgagcactg tccagtgtac ccatgggatc      720

atgccagtgg tcagtaccca gctgctgctg aacggatcac tggccgagga agagatcatt      780

atccggtccg aaaatctgac caacaatatc aagaccatta tcgtgcacct gaacaagtcc      840

gtggagatcg tctgcaccag acctaacaat aacacaagga aatctattcg catcggccca      900

gggcagacat tttacgctac tggggaaatt atcggaaata ttcgggaggc acattgcaat      960

atctcaaaga gcaactggac cagcacactg gagcaggtga agaagaagct gaaggaacac     1020

tacaataaga caatcgagtt caacccccct tctggcgggg acctggaagt gactacccat     1080

agttttaatt gcagaggcga gttcttttat tgtaacacaa ctaaactgtt ctctaacaac     1140

tccgattcta acaacgaaac tattaccctg ccatgcaaaa tcaagcagat tatcaacatg     1200

tggcagaaag tggggagggc aatgtatgcc ccacccattg agggaaatat cacctgtaaa     1260

agtaacatta ctggcctgct gctgacccgc gacggaggca agaataccac aaacgaaatc     1320

tttagacccg ggggaggcaa tatgaaagat aactggagga gtgagctgta caaatataag     1380

gtggtcgaga ttgaacccct gggcgtggcc cctaccaaat caaagaggcg agtggtcgag     1440

ggcggtggag gctcaggtgg aggcggatcc gcagtgggac tgggagctgt cctgctgggg     1500

ttcctgggag cagctggctc aacaatgggc gcagccagca tcacactgac tgtgcaggca     1560

cgacagctgc tgtccgggat tgtccagcag cagtctaacc tgctgagagc tcccgaagca     1620

cagcagcaca tgctgcagct gactgtgtgg ggaattaagc agctgcagac ccgagtcctg     1680

gcaatcgagc ggtacctgaa agaccagcag ctgctgggac tgtggggatg ctccggcaag     1740

attatctgta ctaccgctgt gccctggaac agcagctgga gtaacaagtc acaggaggac     1800

atctgggata atatgacatg gatgcagtgg gaccgcgaaa tttcaaacta caccggcaca     1860

atctatcgac tgctggagga tagccagaat cagcaggaga agaacgaaaa ggacctgctg     1920

gccctggatg cggccgcatg a                                               1941


<210>  18
<211>  2100
<212>  DNA
<213>  Artificial

<220>
<223>  Du151 Gp140FL fused to truncated HA2 of influenza

<400>  18
atggagtggt cttggatctt cctgttcctg ctgtctggga ctgctggagt gcatagttcc       60

ggagtcggca acctgaatct gtgggtgacc gtgtactatg gcgtgcccgt ctggaaagaa      120

gcaaagacca cactgttttg cgccagcgac gctaaagcat acgataagga ggtgcacaat      180

gtctgggcca cacatgcttg tgtgcctact gaccctaatc cacgggagat cgtgctggaa      240

aacgtcactg agaatttcaa catgtggaag aacgacatgg tggatcagat gcacgaggac      300

atcatttctc tgtgggatca gagtctgaaa ccatgcgtga agctgacccc cctgtgcgtc      360

acactgaatt gtactaacgc ccctgcttac aacaatagca tgcatgggga aatgaagaac      420

tgttccttta acactaccac agagatccga gaccggaaac agaaggcata cgccctgttc      480

tataagcctg atgtggtccc actgaaccgg agagaggaaa acaatggaac aggcgagtat      540

attctgatta actgcaacag ctccacaatt actcaggcct gtccaaaagt gacttttgat      600

cccattccta tccactactg cgctcccgca ggctatgcta tcctgaaatg taacaataag      660

accttcaatg ggacaggacc ttgcaacaat gtgagcactg tccagtgtac ccatgggatc      720

atgccagtgg tcagtaccca gctgctgctg aacggatcac tggccgagga agagatcatt      780

atccggtccg aaaatctgac caacaatatc aagaccatta tcgtgcacct gaacaagtcc      840

gtggagatcg tctgcaccag acctaacaat aacacaagga aatctattcg catcggccca      900

gggcagacat tttacgctac tggggaaatt atcggaaata ttcgggaggc acattgcaat      960

atctcaaaga gcaactggac cagcacactg gagcaggtga agaagaagct gaaggaacac     1020

tacaataaga caatcgagtt caacccccct tctggcgggg acctggaagt gactacccat     1080

agttttaatt gcagaggcga gttcttttat tgtaacacaa ctaaactgtt ctctaacaac     1140

tccgattcta acaacgaaac tattaccctg ccatgcaaaa tcaagcagat tatcaacatg     1200

tggcagaaag tggggagggc aatgtatgcc ccacccattg agggaaatat cacctgtaaa     1260

agtaacatta ctggcctgct gctgacccgc gacggaggca agaataccac aaacgaaatc     1320

tttagacccg ggggaggcaa tatgaaagat aactggagga gtgagctgta caaatataag     1380

gtggtcgaga ttgaacccct gggcgtggcc cctaccaaat caaagaggcg agtggtcgag     1440

ggcggtggag gctcaggtgg aggcggatcc gcagtgggac tgggagctgt cctgctgggg     1500

ttcctgggag cagctggctc aacaatgggc gcagccagca tcacactgac tgtgcaggca     1560

cgacagctgc tgtccgggat tgtccagcag cagtctaacc tgctgagagc tcccgaagca     1620

cagcagcaca tgctgcagct gactgtgtgg ggaattaagc agctgcagac ccgagtcctg     1680

gcaatcgagc ggtacctgaa agaccagcag ctgctgggac tgtggggatg ctccggcaag     1740

attatctgta ctaccgctgt gccctggaac agcagctgga gtaacaagtc acaggaggac     1800

atctgggata atatgacatg gatgcagtgg gaccgcgaaa tttcaaacta caccggcaca     1860

atctatcgac tgctggagga tagccagaat cagcaggaga agaacgaaaa ggacctgctg     1920

gccctggatt cttggaaaaa tctgtggaac tggttcaata tcaccaactg gctgtggtac     1980

attcagatcc tgagtatcta ttcaaccgtg gcttcaagcc tggctctggc aattatggtc     2040

gcaggcctgt ctctgtggat gtgcagcaac gggtccctgc agtgtcgagc ggccgcatga     2100


<210>  19
<211>  2109
<212>  DNA
<213>  Artificial

<220>
<223>  Du151 Gp120FL fused to HA2 of influenza

<400>  19
atggagtggt cttggatctt cctgttcctg ctgtctggga ctgctggagt gcatagttcc       60

ggagtcggca acctgaatct gtgggtgacc gtgtactatg gcgtgcccgt ctggaaagaa      120

gcaaagacca cactgttttg cgccagcgac gctaaagcat acgataagga ggtgcacaat      180

gtctgggcca cacatgcttg tgtgcctact gaccctaatc cacgggagat cgtgctggaa      240

aacgtcactg agaatttcaa catgtggaag aacgacatgg tggatcagat gcacgaggac      300

atcatttctc tgtgggatca gagtctgaaa ccatgcgtga agctgacccc cctgtgcgtc      360

acactgaatt gtactaacgc ccctgcttac aacaatagca tgcatgggga aatgaagaac      420

tgttccttta acactaccac agagatccga gaccggaaac agaaggcata cgccctgttc      480

tataagcctg atgtggtccc actgaaccgg agagaggaaa acaatggaac aggcgagtat      540

attctgatta actgcaacag ctccacaatt actcaggcct gtccaaaagt gacttttgat      600

cccattccta tccactactg cgctcccgca ggctatgcta tcctgaaatg taacaataag      660

accttcaatg ggacaggacc ttgcaacaat gtgagcactg tccagtgtac ccatgggatc      720

atgccagtgg tcagtaccca gctgctgctg aacggatcac tggccgagga agagatcatt      780

atccggtccg aaaatctgac caacaatatc aagaccatta tcgtgcacct gaacaagtcc      840

gtggagatcg tctgcaccag acctaacaat aacacaagga aatctattcg catcggccca      900

gggcagacat tttacgctac tggggaaatt atcggaaata ttcgggaggc acattgcaat      960

atctcaaaga gcaactggac cagcacactg gagcaggtga agaagaagct gaaggaacac     1020

tacaataaga caatcgagtt caacccccct tctggcgggg acctggaagt gactacccat     1080

agttttaatt gcagaggcga gttcttttat tgtaacacaa ctaaactgtt ctctaacaac     1140

tccgattcta acaacgaaac tattaccctg ccatgcaaaa tcaagcagat tatcaacatg     1200

tggcagaaag tggggagggc aatgtatgcc ccacccattg agggaaatat cacctgtaaa     1260

agtaacatta ctggcctgct gctgacccgc gacggaggca agaataccac aaacgaaatc     1320

tttagacccg ggggaggcaa tatgaaagat aactggagga gtgagctgta caaatataag     1380

gtggtcgaga ttgaacccct gggcgtggcc cctaccaaat caaagaggcg agtggtcgag     1440

ggcggtggag gctcaggtgg aggcggatcc gaggggggat ggcagggaat ggtggacggg     1500

tggtacggat atcaccattc aaacgaacag gggagcggat atgccgctga caaggagtct     1560

acacagaaag caatcgatgg ggtgactaac aaggtcaata gtatcatcga taagatgaat     1620

acccagttcg aagccgtggg acgcgagttt aacaatctgg aacgccgaat cgagaacctg     1680

aataagaaaa tggaagacgg cttcctggat gtgtggacct acaacgctga gctgctggtc     1740

ctgatggaaa atgagcggac actggacttt cacgatagca acgtgaagaa tctgtatgac     1800

aaagtcagac tgcagctgag ggataacgcc aaggaactgg gcaatgggtg cttcgagttt     1860

taccataaat gcgacaacga atgtatggag agtgtgcgca atggcaccta cgattatcct     1920

cagtattcag aagaggcccg gctgaagaga gaagagatta gcggcgtgaa actggagtct     1980

attggcatct accagatcct gagtatctat tcaaccgtgg cttcaagcct ggctctggca     2040

attatggtcg caggcctgtc tctgtggatg tgcagcaacg ggtccctgca gtgtcgagcg     2100

gccgcatga                                                             2109


<210>  20
<211>  2178
<212>  DNA
<213>  Artificial

<220>
<223>  Du151 Gp150FL

<400>  20
atggagtggt cttggatctt cctgttcctg ctgtctggga ctgctggagt gcatagttcc       60

ggagtcggca acctgaatct gtgggtgacc gtgtactatg gcgtgcccgt ctggaaagaa      120

gcaaagacca cactgttttg cgccagcgac gctaaagcat acgataagga ggtgcacaat      180

gtctgggcca cacatgcttg tgtgcctact gaccctaatc cacgggagat cgtgctggaa      240

aacgtcactg agaatttcaa catgtggaag aacgacatgg tggatcagat gcacgaggac      300

atcatttctc tgtgggatca gagtctgaaa ccatgcgtga agctgacccc cctgtgcgtc      360

acactgaatt gtactaacgc ccctgcttac aacaatagca tgcatgggga aatgaagaac      420

tgttccttta acactaccac agagatccga gaccggaaac agaaggcata cgccctgttc      480

tataagcctg atgtggtccc actgaaccgg agagaggaaa acaatggaac aggcgagtat      540

attctgatta actgcaacag ctccacaatt actcaggcct gtccaaaagt gacttttgat      600

cccattccta tccactactg cgctcccgca ggctatgcta tcctgaaatg taacaataag      660

accttcaatg ggacaggacc ttgcaacaat gtgagcactg tccagtgtac ccatgggatc      720

atgccagtgg tcagtaccca gctgctgctg aacggatcac tggccgagga agagatcatt      780

atccggtccg aaaatctgac caacaatatc aagaccatta tcgtgcacct gaacaagtcc      840

gtggagatcg tctgcaccag acctaacaat aacacaagga aatctattcg catcggccca      900

gggcagacat tttacgctac tggggaaatt atcggaaata ttcgggaggc acattgcaat      960

atctcaaaga gcaactggac cagcacactg gagcaggtga agaagaagct gaaggaacac     1020

tacaataaga caatcgagtt caacccccct tctggcgggg acctggaagt gactacccat     1080

agttttaatt gcagaggcga gttcttttat tgtaacacaa ctaaactgtt ctctaacaac     1140

tccgattcta acaacgaaac tattaccctg ccatgcaaaa tcaagcagat tatcaacatg     1200

tggcagaaag tggggagggc aatgtatgcc ccacccattg agggaaatat cacctgtaaa     1260

agtaacatta ctggcctgct gctgacccgc gacggaggca agaataccac aaacgaaatc     1320

tttagacccg ggggaggcaa tatgaaagat aactggagga gtgagctgta caaatataag     1380

gtggtcgaga ttgaacccct gggcgtggcc cctaccaaat caaagaggcg agtggtcgag     1440

ggcggtggag gctcaggtgg aggcggatcc gcagtgggac tgggagctgt cctgctgggg     1500

ttcctgggag cagctggctc aacaatgggc gcagccagca tcacactgac tgtgcaggca     1560

cgacagctgc tgtccgggat tgtccagcag cagtctaacc tgctgagagc tcccgaagca     1620

cagcagcaca tgctgcagct gactgtgtgg ggaattaagc agctgcagac ccgagtcctg     1680

gcaatcgagc ggtacctgaa agaccagcag ctgctgggac tgtggggatg ctccggcaag     1740

attatctgta ctaccgctgt gccctggaac agcagctgga gtaacaagtc acaggaggac     1800

atctgggata atatgacatg gatgcagtgg gaccgcgaaa tttcaaacta caccggcaca     1860

atctatcgac tgctggagga tagccagaat cagcaggaga agaacgaaaa ggacctgctg     1920

gccctggatt cttggaaaaa tctgtggaac tggttcaata tcaccaactg gctgtggtac     1980

attaagatct ttattatgat cgtgggggga ctgattggac tgaggattat ctttggcgtg     2040

ctggccatcg tgaagagagt caggcagggc tatagccccc tgtccttcca gactctgacc     2100

ccaagccccc gcggccctga tcggctgggg agaatcgaag aggaaggcgg ggagcaggac     2160

aaggatgcgg ccgcatga                                                   2178


<210>  21
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  LPH Secretory Signal Peptide

<400>  21

Met Glu Trp Ser Trp Ile Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly 
1               5                   10                  15      


Val His Ser Ser Gly 
            20      


<210>  22
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Flexible Linker

<400>  22

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


