                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  MOLECULAR RHEOSTAT FOR COFACTOR BALANCE

<130>  00011-087WO1

<140>  Not yet assigned
<141>  2017-10-18

<150>  US 62/409,731
<151>  2016-10-18

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  319
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  1

Met Lys Arg Ile Gly Val Leu Thr Ser Gly Gly Asp Ser Pro Gly Met 
1               5                   10                  15      


Asn Ala Ala Ile Arg Ser Val Val Arg Lys Ala Ile Tyr His Gly Val 
            20                  25                  30          


Glu Val Tyr Gly Val Tyr His Gly Tyr Ala Gly Leu Ile Ala Gly Asn 
        35                  40                  45              


Ile Lys Lys Leu Glu Val Gly Asp Val Gly Asp Ile Ile His Arg Gly 
    50                  55                  60                  


Gly Thr Ile Leu Tyr Thr Ala Arg Cys Pro Glu Phe Lys Thr Glu Glu 
65                  70                  75                  80  


Gly Gln Lys Lys Gly Ile Glu Gln Leu Lys Lys His Gly Ile Glu Gly 
                85                  90                  95      


Leu Val Val Ile Gly Gly Asp Gly Ser Tyr Gln Gly Ala Lys Lys Leu 
            100                 105                 110         


Thr Glu His Gly Phe Pro Cys Val Gly Val Pro Gly Thr Ile Asp Asn 
        115                 120                 125             


Asp Ile Pro Gly Thr Asp Phe Thr Ile Gly Phe Asp Thr Ala Leu Asn 
    130                 135                 140                 


Thr Val Ile Asp Ala Ile Asp Lys Ile Arg Asp Thr Ala Thr Ser His 
145                 150                 155                 160 


Glu Arg Thr Tyr Val Ile Glu Val Met Gly Arg His Ala Gly Asp Ile 
                165                 170                 175     


Ala Leu Trp Ser Gly Leu Ala Gly Gly Ala Glu Thr Ile Leu Ile Pro 
            180                 185                 190         


Glu Ala Asp Tyr Asp Met Asn Asp Val Ile Ala Arg Leu Lys Arg Gly 
        195                 200                 205             


His Glu Arg Gly Lys Lys His Ser Ile Ile Ile Val Ala Glu Gly Val 
    210                 215                 220                 


Gly Ser Gly Val Asp Phe Gly Arg Gln Ile Gln Glu Ala Thr Gly Phe 
225                 230                 235                 240 


Glu Thr Arg Val Thr Val Leu Gly His Val Gln Arg Gly Gly Ser Pro 
                245                 250                 255     


Thr Ala Phe Asp Arg Val Leu Ala Ser Arg Leu Gly Ala Arg Ala Val 
            260                 265                 270         


Glu Leu Leu Leu Glu Gly Lys Gly Gly Arg Cys Val Gly Ile Gln Asn 
        275                 280                 285             


Asn Gln Leu Val Asp His Asp Ile Ala Glu Ala Leu Ala Asn Lys His 
    290                 295                 300                 


Thr Ile Asp Gln Arg Met Tyr Ala Leu Ser Lys Glu Leu Ser Ile 
305                 310                 315                 


<210>  2
<211>  253
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  2

Met Arg Lys Pro Ile Ile Ala Gly Asn Trp Lys Met His Lys Thr Leu 
1               5                   10                  15      


Ala Glu Ala Val Gln Phe Val Glu Asp Val Lys Gly His Val Pro Pro 
            20                  25                  30          


Ala Asp Glu Val Asp Ser Val Val Cys Ala Pro Phe Leu Phe Leu Asp 
        35                  40                  45              


Arg Leu Val Gln Ala Ala Asp Gly Thr Asp Leu Lys Ile Gly Ala Gln 
    50                  55                  60                  


Thr Met His Phe Ala Asp Gln Gly Ala Tyr Thr Gly Glu Val Ser Pro 
65                  70                  75                  80  


Val Met Leu Lys Asp Leu Gly Val Thr Tyr Val Ile Leu Gly His Ser 
                85                  90                  95      


Glu Arg Arg Gln Met Phe Ala Glu Thr Asp Glu Thr Val Asn Lys Lys 
            100                 105                 110         


Val Leu Ala Ala Phe Thr Arg Gly Leu Ile Pro Ile Ile Cys Cys Gly 
        115                 120                 125             


Glu Ser Leu Glu Glu Arg Glu Ala Gly Gln Thr Asn Ala Val Val Ala 
    130                 135                 140                 


Ser Gln Val Glu Lys Ala Leu Ala Gly Leu Thr Pro Glu Gln Val Lys 
145                 150                 155                 160 


Gln Ala Val Ile Ala Tyr Glu Pro Ile Trp Ala Ile Gly Thr Gly Lys 
                165                 170                 175     


Ser Ser Thr Pro Glu Asp Ala Asn Ser Val Cys Gly His Ile Arg Ser 
            180                 185                 190         


Val Val Ser Arg Leu Phe Gly Pro Glu Ala Ala Glu Ala Ile Arg Ile 
        195                 200                 205             


Gln Tyr Gly Gly Ser Val Lys Pro Asp Asn Ile Arg Asp Phe Leu Ala 
    210                 215                 220                 


Gln Gln Gln Ile Asp Gly Ala Leu Val Gly Gly Ala Ser Leu Glu Pro 
225                 230                 235                 240 


Ala Ser Phe Leu Gln Leu Val Glu Ala Gly Arg His Glu 
                245                 250             


<210>  3
<211>  299
<212>  PRT
<213>  Staphylococcus aureus

<400>  3

Met Glu Ser Met Asn Lys Glu Gln Leu Glu Lys Met Lys Asn Gly Lys 
1               5                   10                  15      


Gly Phe Ile Ala Ala Leu Asp Gln Ser Gly Gly Ser Thr Pro Lys Ala 
            20                  25                  30          


Leu Lys Glu Tyr Gly Val Asn Glu Asp Gln Tyr Ser Asn Glu Asp Glu 
        35                  40                  45              


Met Phe Gln Leu Val His Asp Met Arg Thr Arg Val Val Thr Ser Pro 
    50                  55                  60                  


Ser Phe Ser Pro Asp Lys Ile Leu Gly Ala Ile Leu Phe Glu Gln Thr 
65                  70                  75                  80  


Met Asp Arg Glu Val Glu Ser Lys Tyr Thr Ala Asp Tyr Leu Ala Asp 
                85                  90                  95      


Lys Gly Val Val Pro Phe Leu Lys Val Asp Lys Gly Leu Ala Glu Glu 
            100                 105                 110         


Gln Asn Gly Val Gln Leu Met Lys Pro Ile Asp Asn Leu Asp Asn Leu 
        115                 120                 125             


Leu Asp Arg Ala Asn Glu Arg His Ile Phe Gly Thr Lys Met Arg Ser 
    130                 135                 140                 


Asn Ile Leu Glu Leu Asn Glu Gln Gly Ile Lys Asp Val Val Glu Gln 
145                 150                 155                 160 


Gln Phe Glu Val Ala Lys Gln Ile Ile Ala Lys Gly Leu Val Pro Ile 
                165                 170                 175     


Ile Glu Pro Glu Val Asn Ile Asn Ala Lys Asp Lys Ala Glu Ile Glu 
            180                 185                 190         


Lys Val Leu Lys Ala Glu Leu Lys Lys Gly Leu Asp Ser Leu Asn Ala 
        195                 200                 205             


Asp Gln Leu Val Met Leu Lys Leu Thr Ile Pro Thr Glu Pro Asn Leu 
    210                 215                 220                 


Tyr Lys Glu Leu Ala Glu His Pro Asn Val Val Arg Val Val Val Leu 
225                 230                 235                 240 


Ser Gly Gly Tyr Ser Arg Glu Lys Ala Asn Glu Leu Leu Lys Asp Asn 
                245                 250                 255     


Ala Glu Leu Ile Ala Ser Phe Ser Arg Ala Leu Ala Ser Asp Leu Arg 
            260                 265                 270         


Ala Asp Gln Ser Lys Glu Glu Phe Asp Lys Ala Leu Gly Asp Ala Val 
        275                 280                 285             


Glu Ser Ile Tyr Asp Ala Ser Val Asn Lys Asn 
    290                 295                 


<210>  4
<211>  449
<212>  PRT
<213>  Geobacillus thermodenitrificans

<400>  4

Met Thr His Ile Arg Phe Asp Tyr Ser Lys Ala Leu Ala Phe Phe Gly 
1               5                   10                  15      


Glu His Glu Leu Thr Tyr Leu Arg Asp Ala Val Lys Val Ala His His 
            20                  25                  30          


Ser Leu His Glu Lys Thr Gly Val Gly Asn Asp Phe Leu Gly Trp Leu 
        35                  40                  45              


Asp Trp Pro Val Asn Tyr Asp Lys Glu Glu Phe Ala Arg Ile Lys Gln 
    50                  55                  60                  


Ala Ala Lys Lys Ile Gln Ser Asp Ser Asp Val Leu Leu Val Ile Gly 
65                  70                  75                  80  


Ile Gly Gly Ser Tyr Leu Gly Ala Arg Ala Ala Ile Glu Met Leu His 
                85                  90                  95      


His Ser Phe Tyr Asn Ala Leu Pro Lys Glu Lys Arg Ser Thr Pro Gln 
            100                 105                 110         


Ile Ile Phe Val Gly Asn Asn Ile Ser Ser Thr Tyr Met Lys Asp Val 
        115                 120                 125             


Ile Asp Phe Leu Glu Gly Lys Asp Phe Ser Ile Asn Val Ile Ser Lys 
    130                 135                 140                 


Ser Gly Thr Thr Thr Glu Pro Ala Ile Ala Phe Arg Ile Phe Arg Lys 
145                 150                 155                 160 


Leu Leu Glu Asp Lys Tyr Gly Lys Glu Glu Ala Arg Arg Arg Ile Tyr 
                165                 170                 175     


Ala Thr Thr Asp Arg Ala Arg Gly Ala Leu Arg Thr Leu Ala Asp Glu 
            180                 185                 190         


Glu Gly Tyr Glu Thr Phe Val Ile Pro Asp Asp Ile Gly Gly Arg Tyr 
        195                 200                 205             


Ser Val Leu Thr Ala Val Gly Leu Leu Pro Ile Ala Ala Ser Gly Ala 
    210                 215                 220                 


Asp Ile Asp Ala Met Met Glu Gly Ala Ala Lys Ala Arg Glu Asp Phe 
225                 230                 235                 240 


Ser Arg Ser Glu Leu Glu Glu Asn Ala Ala Tyr Gln Tyr Ala Ala Ile 
                245                 250                 255     


Arg Asn Ile Leu Tyr Asn Lys Gly Lys Thr Ile Glu Leu Leu Val Asn 
            260                 265                 270         


Tyr Glu Pro Ala Leu His Tyr Phe Ala Glu Trp Trp Lys Gln Leu Phe 
        275                 280                 285             


Gly Glu Ser Glu Gly Lys Asp Gln Lys Gly Ile Tyr Pro Ala Ser Ala 
    290                 295                 300                 


Asp Phe Ser Thr Asp Leu His Ser Leu Gly Gln Tyr Ile Gln Glu Gly 
305                 310                 315                 320 


Arg Arg Asp Leu Phe Glu Thr Val Leu Lys Leu Glu Glu Pro Arg His 
                325                 330                 335     


Glu Leu Val Ile Glu Ala Glu Glu Ser Asp Leu Asp Gly Leu Asn Tyr 
            340                 345                 350         


Leu Ala Gly Gln Thr Val Asp Phe Val Asn Thr Lys Ala Phe Glu Gly 
        355                 360                 365             


Thr Leu Leu Ala His Thr Asp Gly Gly Val Pro Asn Leu Val Val Thr 
    370                 375                 380                 


Leu Pro Lys Leu Asp Glu Tyr Thr Phe Gly Tyr Leu Val Tyr Phe Phe 
385                 390                 395                 400 


Glu Lys Ala Cys Ala Met Ser Gly Tyr Leu Leu Gly Val Asn Pro Phe 
                405                 410                 415     


Asp Gln Pro Gly Val Glu Ala Tyr Lys Lys Asn Met Phe Ala Leu Leu 
            420                 425                 430         


Gly Lys Pro Gly Tyr Glu Glu Leu Lys Asp Glu Leu Glu Lys Arg Leu 
        435                 440                 445             


Lys 
    


<210>  5
<211>  475
<212>  PRT
<213>  Streptococcus mutans

<400>  5

Met Thr Lys Gln Tyr Lys Asn Tyr Val Asn Gly Glu Trp Lys Leu Ser 
1               5                   10                  15      


Glu Asn Glu Ile Lys Ile Tyr Glu Pro Ala Ser Gly Ala Glu Leu Gly 
            20                  25                  30          


Ser Val Pro Ala Met Ser Thr Glu Glu Val Asp Tyr Val Tyr Ala Ser 
        35                  40                  45              


Ala Lys Lys Ala Gln Pro Ala Trp Arg Ser Leu Ser Tyr Ile Glu Arg 
    50                  55                  60                  


Ala Ala Tyr Leu His Lys Val Ala Asp Ile Leu Met Arg Asp Lys Glu 
65                  70                  75                  80  


Lys Ile Gly Ala Val Leu Ser Lys Glu Val Ala Lys Gly Tyr Lys Ser 
                85                  90                  95      


Ala Val Ser Glu Val Val Arg Thr Ala Glu Ile Ile Asn Tyr Ala Ala 
            100                 105                 110         


Glu Glu Gly Leu Arg Met Glu Gly Glu Val Leu Glu Gly Gly Ser Phe 
        115                 120                 125             


Glu Ala Ala Ser Lys Lys Lys Ile Ala Val Val Arg Arg Glu Pro Val 
    130                 135                 140                 


Gly Leu Val Leu Ala Ile Ser Pro Phe Asn Tyr Pro Val Asn Leu Ala 
145                 150                 155                 160 


Gly Ser Lys Ile Ala Pro Ala Leu Ile Ala Gly Asn Val Ile Ala Phe 
                165                 170                 175     


Lys Pro Pro Thr Gln Gly Ser Ile Ser Gly Leu Leu Leu Ala Glu Ala 
            180                 185                 190         


Phe Ala Glu Ala Gly Leu Pro Ala Gly Val Phe Asn Thr Ile Thr Gly 
        195                 200                 205             


Arg Gly Ser Glu Ile Gly Asp Tyr Ile Val Glu His Gln Ala Val Asn 
    210                 215                 220                 


Phe Ile Asn Phe Thr Gly Ser Thr Gly Ile Gly Glu Arg Ile Gly Lys 
225                 230                 235                 240 


Met Ala Gly Met Arg Pro Ile Met Leu Glu Leu Gly Gly Lys Asp Ser 
                245                 250                 255     


Ala Ile Val Leu Glu Asp Ala Asp Leu Glu Leu Thr Ala Lys Asn Ile 
            260                 265                 270         


Ile Ala Gly Ala Phe Gly Tyr Ser Gly Gln Arg Cys Thr Ala Val Lys 
        275                 280                 285             


Arg Val Leu Val Met Glu Ser Val Ala Asp Glu Leu Val Glu Lys Ile 
    290                 295                 300                 


Arg Glu Lys Val Leu Ala Leu Thr Ile Gly Asn Pro Glu Asp Asp Ala 
305                 310                 315                 320 


Asp Ile Thr Pro Leu Ile Asp Thr Lys Ser Ala Asp Tyr Val Glu Gly 
                325                 330                 335     


Leu Ile Asn Asp Ala Asn Asp Lys Gly Ala Ala Ala Leu Thr Glu Ile 
            340                 345                 350         


Lys Arg Glu Gly Asn Leu Ile Cys Pro Ile Leu Phe Asp Lys Val Thr 
        355                 360                 365             


Thr Asp Met Arg Leu Ala Trp Glu Glu Pro Phe Gly Pro Val Leu Pro 
    370                 375                 380                 


Ile Ile Arg Val Thr Ser Val Glu Glu Ala Ile Glu Ile Ser Asn Lys 
385                 390                 395                 400 


Ser Glu Tyr Gly Leu Gln Ala Ser Ile Phe Thr Asn Asp Phe Pro Arg 
                405                 410                 415     


Ala Phe Gly Ile Ala Glu Gln Leu Glu Val Gly Thr Val His Ile Asn 
            420                 425                 430         


Asn Lys Thr Gln Arg Gly Thr Asp Asn Phe Pro Phe Leu Gly Ala Lys 
        435                 440                 445             


Lys Ser Gly Ala Gly Ile Gln Gly Val Lys Tyr Ser Ile Glu Ala Met 
    450                 455                 460                 


Thr Thr Val Lys Ser Val Val Phe Asp Ile Lys 
465                 470                 475 


<210>  6
<211>  335
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  6

Met Ala Val Lys Val Gly Ile Asn Gly Phe Gly Arg Ile Gly Arg Asn 
1               5                   10                  15      


Val Phe Arg Ala Ala Leu Lys Asn Pro Asp Ile Glu Val Val Ala Val 
            20                  25                  30          


Asn Asp Leu Thr Asp Ala Asn Thr Leu Ala His Leu Leu Lys Tyr Asp 
        35                  40                  45              


Ser Val His Gly Arg Leu Asp Ala Glu Val Ser Val Asn Gly Asn Asn 
    50                  55                  60                  


Leu Val Val Asn Gly Lys Glu Ile Ile Val Lys Ala Glu Arg Asp Pro 
65                  70                  75                  80  


Glu Asn Leu Ala Trp Gly Glu Ile Gly Val Asp Ile Val Val Glu Ser 
                85                  90                  95      


Thr Gly Arg Phe Thr Lys Arg Glu Asp Ala Ala Lys His Leu Glu Ala 
            100                 105                 110         


Gly Ala Lys Lys Val Ile Ile Ser Ala Pro Ala Lys Asn Glu Asp Ile 
        115                 120                 125             


Thr Ile Val Met Gly Val Asn Gln Asp Lys Tyr Asp Pro Lys Ala His 
    130                 135                 140                 


His Val Ile Ser Asn Ala Ser Cys Thr Thr Asn Cys Leu Ala Pro Phe 
145                 150                 155                 160 


Ala Lys Val Leu His Glu Gln Phe Gly Ile Val Arg Gly Met Met Thr 
                165                 170                 175     


Thr Val His Ser Tyr Thr Asn Asp Gln Arg Ile Leu Asp Leu Pro His 
            180                 185                 190         


Lys Asp Leu Arg Arg Ala Arg Ala Ala Ala Glu Ser Ile Ile Pro Thr 
        195                 200                 205             


Thr Thr Gly Ala Ala Lys Ala Val Ala Leu Val Leu Pro Glu Leu Lys 
    210                 215                 220                 


Gly Lys Leu Asn Gly Met Ala Met Arg Val Pro Thr Pro Asn Val Ser 
225                 230                 235                 240 


Val Val Asp Leu Val Ala Glu Leu Glu Lys Glu Val Thr Val Glu Glu 
                245                 250                 255     


Val Asn Ala Ala Leu Lys Ala Ala Ala Glu Gly Glu Leu Lys Gly Ile 
            260                 265                 270         


Leu Ala Tyr Ser Glu Glu Pro Leu Val Ser Arg Asp Tyr Asn Gly Ser 
        275                 280                 285             


Thr Val Ser Ser Thr Ile Asp Ala Leu Ser Thr Met Val Ile Asp Gly 
    290                 295                 300                 


Lys Met Val Lys Val Val Ser Trp Tyr Asp Asn Glu Thr Gly Tyr Ser 
305                 310                 315                 320 


His Arg Val Val Asp Leu Ala Ala Tyr Ile Ala Ser Lys Gly Leu 
                325                 330                 335 


<210>  7
<211>  394
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  7

Met Asn Lys Lys Thr Ile Arg Asp Val Asp Val Arg Gly Lys Arg Val 
1               5                   10                  15      


Phe Cys Arg Val Asp Phe Asn Val Pro Met Glu Gln Gly Ala Ile Thr 
            20                  25                  30          


Asp Asp Thr Arg Ile Arg Ala Ala Leu Pro Thr Ile Arg Tyr Leu Ile 
        35                  40                  45              


Glu His Gly Ala Lys Val Ile Leu Ala Ser His Leu Gly Arg Pro Lys 
    50                  55                  60                  


Gly Lys Val Val Glu Glu Leu Arg Leu Asp Ala Val Ala Lys Arg Leu 
65                  70                  75                  80  


Gly Glu Leu Leu Glu Arg Pro Val Ala Lys Thr Asn Glu Ala Val Gly 
                85                  90                  95      


Asp Glu Val Lys Ala Ala Val Asp Arg Leu Asn Glu Gly Asp Val Leu 
            100                 105                 110         


Leu Leu Glu Asn Val Arg Phe Tyr Pro Gly Glu Glu Lys Asn Asp Pro 
        115                 120                 125             


Glu Leu Ala Lys Ala Phe Ala Glu Leu Ala Asp Leu Tyr Val Asn Asp 
    130                 135                 140                 


Ala Phe Gly Ala Ala His Arg Ala His Ala Ser Thr Glu Gly Ile Ala 
145                 150                 155                 160 


His Tyr Leu Pro Ala Val Ala Gly Phe Leu Met Glu Lys Glu Leu Glu 
                165                 170                 175     


Val Leu Gly Lys Ala Leu Ser Asn Pro Asp Arg Pro Phe Thr Ala Ile 
            180                 185                 190         


Ile Gly Gly Ala Lys Val Lys Asp Lys Ile Gly Val Ile Asp Asn Leu 
        195                 200                 205             


Leu Glu Lys Val Asp Asn Leu Ile Ile Gly Gly Gly Leu Ala Tyr Thr 
    210                 215                 220                 


Phe Val Lys Ala Leu Gly His Asp Val Gly Lys Ser Leu Leu Glu Glu 
225                 230                 235                 240 


Asp Lys Ile Glu Leu Ala Lys Ser Phe Met Glu Lys Ala Lys Glu Lys 
                245                 250                 255     


Gly Val Arg Phe Tyr Met Pro Val Asp Val Val Val Ala Asp Arg Phe 
            260                 265                 270         


Ala Asn Asp Ala Asn Thr Lys Val Val Pro Ile Asp Ala Ile Pro Ala 
        275                 280                 285             


Asp Trp Ser Ala Leu Asp Ile Gly Pro Lys Thr Arg Glu Leu Tyr Arg 
    290                 295                 300                 


Asp Val Ile Arg Glu Ser Lys Leu Val Val Trp Asn Gly Pro Met Gly 
305                 310                 315                 320 


Val Phe Glu Met Asp Ala Phe Ala His Gly Thr Lys Ala Ile Ala Glu 
                325                 330                 335     


Ala Leu Ala Glu Ala Leu Asp Thr Tyr Ser Val Ile Gly Gly Gly Asp 
            340                 345                 350         


Ser Ala Ala Ala Val Glu Lys Phe Gly Leu Ala Asp Lys Met Asp His 
        355                 360                 365             


Ile Ser Thr Gly Gly Gly Ala Ser Leu Glu Phe Met Glu Gly Lys Gln 
    370                 375                 380                 


Leu Pro Gly Val Val Ala Leu Glu Asp Lys 
385                 390                 


<210>  8
<211>  511
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  8

Met Ser Lys Lys Pro Val Ala Leu Ile Ile Leu Asp Gly Phe Ala Leu 
1               5                   10                  15      


Arg Asp Glu Thr Tyr Gly Asn Ala Val Ala Gln Ala Asn Lys Pro Asn 
            20                  25                  30          


Phe Asp Arg Tyr Trp Asn Glu Tyr Pro His Thr Thr Leu Lys Ala Cys 
        35                  40                  45              


Gly Glu Ala Val Gly Leu Pro Glu Gly Gln Met Gly Asn Ser Glu Val 
    50                  55                  60                  


Gly His Leu Asn Ile Gly Ala Gly Arg Ile Val Tyr Gln Ser Leu Thr 
65                  70                  75                  80  


Arg Ile Asn Ile Ala Ile Arg Glu Gly Glu Phe Asp Arg Asn Glu Thr 
                85                  90                  95      


Phe Leu Ala Ala Met Asn His Val Lys Gln His Gly Thr Ser Leu His 
            100                 105                 110         


Leu Phe Gly Leu Leu Ser Asp Gly Gly Val His Ser His Ile His His 
        115                 120                 125             


Leu Tyr Ala Leu Leu Arg Leu Ala Ala Lys Glu Gly Val Lys Arg Val 
    130                 135                 140                 


Tyr Ile His Gly Phe Leu Asp Gly Arg Asp Val Gly Pro Gln Thr Ala 
145                 150                 155                 160 


Pro Gln Tyr Ile Lys Glu Leu Gln Glu Lys Ile Lys Glu Tyr Gly Val 
                165                 170                 175     


Gly Glu Ile Ala Thr Leu Ser Gly Arg Tyr Tyr Ser Met Asp Arg Asp 
            180                 185                 190         


Lys Arg Trp Asp Arg Val Glu Lys Ala Tyr Arg Ala Met Val Tyr Gly 
        195                 200                 205             


Glu Gly Pro Thr Tyr Arg Asp Pro Leu Glu Cys Ile Glu Asp Ser Tyr 
    210                 215                 220                 


Lys His Gly Ile Tyr Asp Glu Phe Val Leu Pro Ser Val Ile Val Arg 
225                 230                 235                 240 


Glu Asp Gly Arg Pro Val Ala Thr Ile Gln Asp Asn Asp Ala Ile Ile 
                245                 250                 255     


Phe Tyr Asn Phe Arg Pro Asp Arg Ala Ile Gln Ile Ser Asn Thr Phe 
            260                 265                 270         


Thr Asn Glu Asp Phe Arg Glu Phe Asp Arg Gly Pro Lys His Pro Lys 
        275                 280                 285             


His Leu Phe Phe Val Cys Leu Thr His Phe Ser Glu Thr Val Lys Gly 
    290                 295                 300                 


Tyr Val Ala Phe Lys Pro Thr Asn Leu Asp Asn Thr Ile Gly Glu Val 
305                 310                 315                 320 


Leu Ser Gln His Gly Leu Arg Gln Leu Arg Ile Ala Glu Thr Glu Lys 
                325                 330                 335     


Tyr Pro His Val Thr Phe Phe Met Ser Gly Gly Arg Glu Glu Lys Phe 
            340                 345                 350         


Pro Gly Glu Asp Arg Ile Leu Ile Asn Ser Pro Lys Val Pro Thr Tyr 
        355                 360                 365             


Asp Leu Lys Pro Glu Met Ser Ala Tyr Glu Val Thr Asp Ala Leu Leu 
    370                 375                 380                 


Lys Glu Ile Glu Ala Asp Lys Tyr Asp Ala Ile Ile Leu Asn Tyr Ala 
385                 390                 395                 400 


Asn Pro Asp Met Val Gly His Ser Gly Lys Leu Glu Pro Thr Ile Lys 
                405                 410                 415     


Ala Val Glu Ala Val Asp Glu Cys Leu Gly Lys Val Val Asp Ala Ile 
            420                 425                 430         


Leu Ala Lys Gly Gly Ile Ala Ile Ile Thr Ala Asp His Gly Asn Ala 
        435                 440                 445             


Asp Glu Val Leu Thr Pro Asp Gly Lys Pro Gln Thr Ala His Thr Thr 
    450                 455                 460                 


Asn Pro Val Pro Val Ile Val Thr Lys Lys Gly Ile Lys Leu Arg Asp 
465                 470                 475                 480 


Gly Gly Ile Leu Gly Asp Leu Ala Pro Thr Met Leu Asp Leu Leu Gly 
                485                 490                 495     


Leu Pro Gln Pro Lys Glu Met Thr Gly Lys Ser Leu Ile Val Lys 
            500                 505                 510     


<210>  9
<211>  432
<212>  PRT
<213>  Escherichia coli

<400>  9

Met Ser Lys Ile Val Lys Ile Ile Gly Arg Glu Ile Ile Asp Ser Arg 
1               5                   10                  15      


Gly Asn Pro Thr Val Glu Ala Glu Val His Leu Glu Gly Gly Phe Val 
            20                  25                  30          


Gly Met Ala Ala Ala Pro Ser Gly Ala Ser Thr Gly Ser Arg Glu Ala 
        35                  40                  45              


Leu Glu Leu Arg Asp Gly Asp Lys Ser Arg Phe Leu Gly Lys Gly Val 
    50                  55                  60                  


Thr Lys Ala Val Ala Ala Val Asn Gly Pro Ile Ala Gln Ala Leu Ile 
65                  70                  75                  80  


Gly Lys Asp Ala Lys Asp Gln Ala Gly Ile Asp Lys Ile Met Ile Asp 
                85                  90                  95      


Leu Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Ala Val Ser Leu Ala Asn Ala Lys Ala Ala Ala Ala Ala Lys Gly Met 
        115                 120                 125             


Pro Leu Tyr Glu His Ile Ala Glu Leu Asn Gly Thr Pro Gly Lys Tyr 
    130                 135                 140                 


Ser Met Pro Val Pro Met Met Asn Ile Ile Asn Gly Gly Glu His Ala 
145                 150                 155                 160 


Asp Asn Asn Val Asp Ile Gln Glu Phe Met Ile Gln Pro Val Gly Ala 
                165                 170                 175     


Lys Thr Val Lys Glu Ala Ile Arg Met Gly Ser Glu Val Phe His His 
            180                 185                 190         


Leu Ala Lys Val Leu Lys Ala Lys Gly Met Asn Thr Ala Val Gly Asp 
        195                 200                 205             


Glu Gly Gly Tyr Ala Pro Asn Leu Gly Ser Asn Ala Glu Ala Leu Ala 
    210                 215                 220                 


Val Ile Ala Glu Ala Val Lys Ala Ala Gly Tyr Glu Leu Gly Lys Asp 
225                 230                 235                 240 


Ile Thr Leu Ala Met Asp Cys Ala Ala Ser Glu Phe Tyr Lys Asp Gly 
                245                 250                 255     


Lys Tyr Val Leu Ala Gly Glu Gly Asn Lys Ala Phe Thr Ser Glu Glu 
            260                 265                 270         


Phe Thr His Phe Leu Glu Glu Leu Thr Lys Gln Tyr Pro Ile Val Ser 
        275                 280                 285             


Ile Glu Asp Gly Leu Asp Glu Ser Asp Trp Asp Gly Phe Ala Tyr Gln 
    290                 295                 300                 


Thr Lys Val Leu Gly Asp Lys Ile Gln Leu Val Gly Asp Asp Leu Phe 
305                 310                 315                 320 


Val Thr Asn Thr Lys Ile Leu Lys Glu Gly Ile Glu Lys Gly Ile Ala 
                325                 330                 335     


Asn Ser Ile Leu Ile Lys Phe Asn Gln Ile Gly Ser Leu Thr Glu Thr 
            340                 345                 350         


Leu Ala Ala Ile Lys Met Ala Lys Asp Ala Gly Tyr Thr Ala Val Ile 
        355                 360                 365             


Ser His Arg Ser Gly Glu Thr Glu Asp Ala Thr Ile Ala Asp Leu Ala 
    370                 375                 380                 


Val Gly Thr Ala Ala Gly Gln Ile Lys Thr Gly Ser Met Ser Arg Ser 
385                 390                 395                 400 


Asp Arg Val Ala Lys Tyr Asn Gln Leu Ile Arg Ile Glu Glu Ala Leu 
                405                 410                 415     


Gly Glu Lys Ala Pro Tyr Asn Gly Arg Lys Glu Ile Lys Gly Gln Ala 
            420                 425                 430         


<210>  10
<211>  470
<212>  PRT
<213>  Escherichia coli

<400>  10

Met Lys Lys Thr Lys Ile Val Cys Thr Ile Gly Pro Lys Thr Glu Ser 
1               5                   10                  15      


Glu Glu Met Leu Ala Lys Met Leu Asp Ala Gly Met Asn Val Met Arg 
            20                  25                  30          


Leu Asn Phe Ser His Gly Asp Tyr Ala Glu His Gly Gln Arg Ile Gln 
        35                  40                  45              


Asn Leu Arg Asn Val Met Ser Lys Thr Gly Lys Thr Ala Ala Ile Leu 
    50                  55                  60                  


Leu Asp Thr Lys Gly Pro Glu Ile Arg Thr Met Lys Leu Glu Gly Gly 
65                  70                  75                  80  


Asn Asp Val Ser Leu Lys Ala Gly Gln Thr Phe Thr Phe Thr Thr Asp 
                85                  90                  95      


Lys Ser Val Ile Gly Asn Ser Glu Met Val Ala Val Thr Tyr Glu Gly 
            100                 105                 110         


Phe Thr Thr Asp Leu Ser Val Gly Asn Thr Val Leu Val Asp Asp Gly 
        115                 120                 125             


Leu Ile Gly Met Glu Val Thr Ala Ile Glu Gly Asn Lys Val Ile Cys 
    130                 135                 140                 


Lys Val Leu Asn Asn Gly Asp Leu Gly Glu Asn Lys Gly Val Asn Leu 
145                 150                 155                 160 


Pro Gly Val Ser Ile Ala Leu Pro Ala Leu Ala Glu Lys Asp Lys Gln 
                165                 170                 175     


Asp Leu Ile Phe Gly Cys Glu Gln Gly Val Asp Phe Val Ala Ala Ser 
            180                 185                 190         


Phe Ile Arg Lys Arg Ser Asp Val Ile Glu Ile Arg Glu His Leu Lys 
        195                 200                 205             


Ala His Gly Gly Glu Asn Ile His Ile Ile Ser Lys Ile Glu Asn Gln 
    210                 215                 220                 


Glu Gly Leu Asn Asn Phe Asp Glu Ile Leu Glu Ala Ser Asp Gly Ile 
225                 230                 235                 240 


Met Val Ala Arg Gly Asp Leu Gly Val Glu Ile Pro Val Glu Glu Val 
                245                 250                 255     


Ile Phe Ala Gln Lys Met Met Ile Glu Lys Cys Ile Arg Ala Arg Lys 
            260                 265                 270         


Val Val Ile Thr Ala Thr Gln Met Leu Asp Ser Met Ile Lys Asn Pro 
        275                 280                 285             


Arg Pro Thr Arg Ala Glu Ala Gly Asp Val Ala Asn Ala Ile Leu Asp 
    290                 295                 300                 


Gly Thr Asp Ala Val Met Leu Ser Gly Glu Ser Ala Lys Gly Lys Tyr 
305                 310                 315                 320 


Pro Leu Glu Ala Val Ser Ile Met Ala Thr Ile Cys Glu Arg Thr Asp 
                325                 330                 335     


Arg Val Met Asn Ser Arg Leu Glu Phe Asn Asn Asp Asn Arg Lys Leu 
            340                 345                 350         


Arg Ile Thr Glu Ala Val Cys Arg Gly Ala Val Glu Thr Ala Glu Lys 
        355                 360                 365             


Leu Asp Ala Pro Leu Ile Val Val Ala Thr Gln Gly Gly Lys Ser Ala 
    370                 375                 380                 


Arg Ala Val Arg Lys Tyr Phe Pro Asp Ala Thr Ile Leu Ala Leu Thr 
385                 390                 395                 400 


Thr Asn Glu Lys Thr Ala His Gln Leu Val Leu Ser Lys Gly Val Val 
                405                 410                 415     


Pro Gln Leu Val Lys Glu Ile Thr Ser Thr Asp Asp Phe Tyr Arg Leu 
            420                 425                 430         


Gly Lys Glu Leu Ala Leu Gln Ser Gly Leu Ala His Lys Gly Asp Val 
        435                 440                 445             


Val Val Met Val Ser Gly Ala Leu Val Pro Ser Gly Thr Thr Asn Thr 
    450                 455                 460                 


Ala Ser Val His Val Leu 
465                 470 


<210>  11
<211>  571
<212>  PRT
<213>  Bacillus subtilis

<400>  11

Met Leu Thr Lys Ala Thr Lys Glu Gln Lys Ser Leu Val Lys Asn Arg 
1               5                   10                  15      


Gly Ala Glu Leu Val Val Asp Cys Leu Val Glu Gln Gly Val Thr His 
            20                  25                  30          


Val Phe Gly Ile Pro Gly Ala Lys Ile Asp Ala Val Phe Asp Ala Leu 
        35                  40                  45              


Gln Asp Lys Gly Pro Glu Ile Ile Val Ala Arg His Glu Gln Asn Ala 
    50                  55                  60                  


Ala Phe Met Ala Gln Ala Val Gly Arg Leu Thr Gly Lys Pro Gly Val 
65                  70                  75                  80  


Val Leu Val Thr Ser Gly Pro Gly Ala Ser Asn Leu Ala Thr Gly Leu 
                85                  90                  95      


Leu Thr Ala Asn Thr Glu Gly Asp Pro Val Val Ala Leu Ala Gly Asn 
            100                 105                 110         


Val Ile Arg Ala Asp Arg Leu Lys Arg Thr His Gln Ser Leu Asp Asn 
        115                 120                 125             


Ala Ala Leu Phe Gln Pro Ile Thr Lys Tyr Ser Val Glu Val Gln Asp 
    130                 135                 140                 


Val Lys Asn Ile Pro Glu Ala Val Thr Asn Ala Phe Arg Ile Ala Ser 
145                 150                 155                 160 


Ala Gly Gln Ala Gly Ala Ala Phe Val Ser Phe Pro Gln Asp Val Val 
                165                 170                 175     


Asn Glu Val Thr Asn Thr Lys Asn Val Arg Ala Val Ala Ala Pro Lys 
            180                 185                 190         


Leu Gly Pro Ala Ala Asp Asp Ala Ile Ser Ala Ala Ile Ala Lys Ile 
        195                 200                 205             


Gln Thr Ala Lys Leu Pro Val Val Leu Val Gly Met Lys Gly Gly Arg 
    210                 215                 220                 


Pro Glu Ala Ile Lys Ala Val Arg Lys Leu Leu Lys Lys Val Gln Leu 
225                 230                 235                 240 


Pro Phe Val Glu Thr Tyr Gln Ala Ala Gly Thr Leu Ser Arg Asp Leu 
                245                 250                 255     


Glu Asp Gln Tyr Phe Gly Arg Ile Gly Leu Phe Arg Asn Gln Pro Gly 
            260                 265                 270         


Asp Leu Leu Leu Glu Gln Ala Asp Val Val Leu Thr Ile Gly Tyr Asp 
        275                 280                 285             


Pro Ile Glu Tyr Asp Pro Lys Phe Trp Asn Ile Asn Gly Asp Arg Thr 
    290                 295                 300                 


Ile Ile His Leu Asp Glu Ile Ile Ala Asp Ile Asp His Ala Tyr Gln 
305                 310                 315                 320 


Pro Asp Leu Glu Leu Ile Gly Asp Ile Pro Ser Thr Ile Asn His Ile 
                325                 330                 335     


Glu His Asp Ala Val Lys Val Glu Phe Ala Glu Arg Glu Gln Lys Ile 
            340                 345                 350         


Leu Ser Asp Leu Lys Gln Tyr Met His Glu Gly Glu Gln Val Pro Ala 
        355                 360                 365             


Asp Trp Lys Ser Asp Arg Ala His Pro Leu Glu Ile Val Lys Glu Leu 
    370                 375                 380                 


Arg Asn Ala Val Asp Asp His Val Thr Val Thr Cys Asp Ile Gly Ser 
385                 390                 395                 400 


His Ala Ile Trp Met Ser Arg Tyr Phe Arg Ser Tyr Glu Pro Leu Thr 
                405                 410                 415     


Leu Met Ile Ser Asn Gly Met Gln Thr Leu Gly Val Ala Leu Pro Trp 
            420                 425                 430         


Ala Ile Gly Ala Ser Leu Val Lys Pro Gly Glu Lys Val Val Ser Val 
        435                 440                 445             


Ser Gly Asp Gly Gly Phe Leu Phe Ser Ala Met Glu Leu Glu Thr Ala 
    450                 455                 460                 


Val Arg Leu Lys Ala Pro Ile Val His Ile Val Trp Asn Asp Ser Thr 
465                 470                 475                 480 


Tyr Asp Met Val Ala Phe Gln Gln Leu Lys Lys Tyr Asn Arg Thr Ser 
                485                 490                 495     


Ala Val Asp Phe Gly Asn Ile Asp Ile Val Lys Tyr Ala Glu Ser Phe 
            500                 505                 510         


Gly Ala Thr Gly Leu Arg Val Glu Ser Pro Asp Gln Leu Ala Asp Val 
        515                 520                 525             


Leu Arg Gln Gly Met Asn Ala Glu Gly Pro Val Ile Ile Asp Val Pro 
    530                 535                 540                 


Val Asp Tyr Ser Asp Asn Ile Asn Leu Ala Ser Asp Lys Leu Pro Lys 
545                 550                 555                 560 


Glu Phe Gly Glu Leu Met Lys Thr Lys Ala Leu 
                565                 570     


<210>  12
<211>  491
<212>  PRT
<213>  Escherichia coli

<400>  12

Met Ala Asn Tyr Phe Asn Thr Leu Asn Leu Arg Gln Gln Leu Ala Gln 
1               5                   10                  15      


Leu Gly Lys Cys Arg Phe Met Gly Arg Asp Glu Phe Ala Asp Gly Ala 
            20                  25                  30          


Ser Tyr Leu Gln Gly Lys Lys Val Val Ile Val Gly Cys Gly Ala Gln 
        35                  40                  45              


Gly Leu Asn Gln Gly Leu Asn Met Arg Asp Ser Gly Leu Asp Ile Ser 
    50                  55                  60                  


Tyr Ala Leu Arg Lys Glu Ala Ile Ala Glu Lys Arg Ala Ser Trp Arg 
65                  70                  75                  80  


Lys Ala Thr Glu Asn Gly Phe Lys Val Gly Thr Tyr Glu Glu Leu Ile 
                85                  90                  95      


Pro Gln Ala Asp Leu Val Ile Asn Leu Thr Pro Asp Lys Gln His Ser 
            100                 105                 110         


Asp Val Val Arg Thr Val Gln Pro Leu Met Lys Asp Gly Ala Ala Leu 
        115                 120                 125             


Gly Tyr Ser His Gly Phe Asn Ile Val Glu Val Gly Glu Gln Ile Arg 
    130                 135                 140                 


Lys Asp Ile Thr Val Val Met Val Ala Pro Lys Cys Pro Gly Thr Glu 
145                 150                 155                 160 


Val Arg Glu Glu Tyr Lys Arg Gly Phe Gly Val Pro Thr Leu Ile Ala 
                165                 170                 175     


Val His Pro Glu Asn Asp Pro Lys Gly Glu Gly Met Ala Ile Ala Lys 
            180                 185                 190         


Ala Trp Ala Ala Ala Thr Gly Gly His Arg Ala Gly Val Leu Glu Ser 
        195                 200                 205             


Ser Phe Val Ala Glu Val Lys Ser Asp Leu Met Gly Glu Gln Thr Ile 
    210                 215                 220                 


Leu Cys Gly Met Leu Gln Ala Gly Ser Leu Leu Cys Phe Asp Lys Leu 
225                 230                 235                 240 


Val Glu Glu Gly Thr Asp Pro Ala Tyr Ala Glu Lys Leu Ile Gln Phe 
                245                 250                 255     


Gly Trp Glu Thr Ile Thr Glu Ala Leu Lys Gln Gly Gly Ile Thr Leu 
            260                 265                 270         


Met Met Asp Arg Leu Ser Asn Pro Ala Lys Leu Arg Ala Tyr Ala Leu 
        275                 280                 285             


Ser Glu Gln Leu Lys Glu Ile Met Ala Pro Leu Phe Gln Lys His Met 
    290                 295                 300                 


Asp Asp Ile Ile Ser Gly Glu Phe Ser Ser Gly Met Met Ala Asp Trp 
305                 310                 315                 320 


Ala Asn Asp Asp Lys Lys Leu Leu Thr Trp Arg Glu Glu Thr Gly Lys 
                325                 330                 335     


Thr Ala Phe Glu Thr Ala Pro Gln Tyr Glu Gly Lys Ile Gly Glu Gln 
            340                 345                 350         


Glu Tyr Phe Asp Lys Gly Val Leu Met Ile Ala Met Val Lys Ala Gly 
        355                 360                 365             


Val Glu Leu Ala Phe Glu Thr Met Val Asp Ser Gly Ile Ile Glu Glu 
    370                 375                 380                 


Ser Ala Tyr Tyr Glu Ser Leu His Glu Leu Pro Leu Ile Ala Asn Thr 
385                 390                 395                 400 


Ile Ala Arg Lys Arg Leu Tyr Glu Met Asn Val Val Ile Ser Asp Thr 
                405                 410                 415     


Ala Glu Tyr Gly Asn Tyr Leu Phe Ser Tyr Ala Cys Val Pro Leu Leu 
            420                 425                 430         


Lys Pro Phe Met Ala Glu Leu Gln Pro Gly Asp Leu Gly Lys Ala Ile 
        435                 440                 445             


Pro Glu Gly Ala Val Asp Asn Gly Gln Leu Arg Asp Val Asn Glu Ala 
    450                 455                 460                 


Ile Arg Ser His Ala Ile Glu Gln Val Gly Lys Lys Leu Arg Gly Tyr 
465                 470                 475                 480 


Met Thr Asp Met Lys Arg Ile Ala Val Ala Gly 
                485                 490     


<210>  13
<211>  616
<212>  PRT
<213>  Escherichia coli

<400>  13

Met Pro Lys Tyr Arg Ser Ala Thr Thr Thr His Gly Arg Asn Met Ala 
1               5                   10                  15      


Gly Ala Arg Ala Leu Trp Arg Ala Thr Gly Met Thr Asp Ala Asp Phe 
            20                  25                  30          


Gly Lys Pro Ile Ile Ala Val Val Asn Ser Phe Thr Gln Phe Val Pro 
        35                  40                  45              


Gly His Val His Leu Arg Asp Leu Gly Lys Leu Val Ala Glu Gln Ile 
    50                  55                  60                  


Glu Ala Ala Gly Gly Val Ala Lys Glu Phe Asn Thr Ile Ala Val Asp 
65                  70                  75                  80  


Asp Gly Ile Ala Met Gly His Gly Gly Met Leu Tyr Ser Leu Pro Ser 
                85                  90                  95      


Arg Glu Leu Ile Ala Asp Ser Val Glu Tyr Met Val Asn Ala His Cys 
            100                 105                 110         


Ala Asp Ala Met Val Cys Ile Ser Asn Cys Asp Lys Ile Thr Pro Gly 
        115                 120                 125             


Met Leu Met Ala Ser Leu Arg Leu Asn Ile Pro Val Ile Phe Val Ser 
    130                 135                 140                 


Gly Gly Pro Met Glu Ala Gly Lys Thr Lys Leu Ser Asp Gln Ile Ile 
145                 150                 155                 160 


Lys Leu Asp Leu Val Asp Ala Met Ile Gln Gly Ala Asp Pro Lys Val 
                165                 170                 175     


Ser Asp Ser Gln Ser Asp Gln Val Glu Arg Ser Ala Cys Pro Thr Cys 
            180                 185                 190         


Gly Ser Cys Ser Gly Met Phe Thr Ala Asn Ser Met Asn Cys Leu Thr 
        195                 200                 205             


Glu Ala Leu Gly Leu Ser Gln Pro Gly Asn Gly Ser Leu Leu Ala Thr 
    210                 215                 220                 


His Ala Asp Arg Lys Gln Leu Phe Leu Asn Ala Gly Lys Arg Ile Val 
225                 230                 235                 240 


Glu Leu Thr Lys Arg Tyr Tyr Glu Gln Asn Asp Glu Ser Ala Leu Pro 
                245                 250                 255     


Arg Asn Ile Ala Ser Lys Ala Ala Phe Glu Asn Ala Met Thr Leu Asp 
            260                 265                 270         


Ile Ala Met Gly Gly Ser Thr Asn Thr Val Leu His Leu Leu Ala Ala 
        275                 280                 285             


Ala Gln Glu Ala Glu Ile Asp Phe Thr Met Ser Asp Ile Asp Lys Leu 
    290                 295                 300                 


Ser Arg Lys Val Pro Gln Leu Cys Lys Val Ala Pro Ser Thr Gln Lys 
305                 310                 315                 320 


Tyr His Met Glu Asp Val His Arg Ala Gly Gly Val Ile Gly Ile Leu 
                325                 330                 335     


Gly Glu Leu Asp Arg Ala Gly Leu Leu Asn Arg Asp Val Lys Asn Val 
            340                 345                 350         


Leu Gly Leu Thr Leu Pro Gln Thr Leu Glu Gln Tyr Asp Val Met Leu 
        355                 360                 365             


Thr Gln Asp Asp Ala Val Lys Asn Met Phe Arg Ala Gly Pro Ala Gly 
    370                 375                 380                 


Ile Arg Thr Thr Gln Ala Phe Ser Gln Asp Cys Arg Trp Asp Thr Leu 
385                 390                 395                 400 


Asp Asp Asp Arg Ala Asn Gly Cys Ile Arg Ser Leu Glu His Ala Tyr 
                405                 410                 415     


Ser Lys Asp Gly Gly Leu Ala Val Leu Tyr Gly Asn Phe Ala Glu Asn 
            420                 425                 430         


Gly Cys Ile Val Lys Thr Ala Gly Val Asp Asp Ser Ile Leu Lys Phe 
        435                 440                 445             


Thr Gly Pro Ala Lys Val Tyr Glu Ser Gln Asp Asp Ala Val Glu Ala 
    450                 455                 460                 


Ile Leu Gly Gly Lys Val Val Ala Gly Asp Val Val Val Ile Arg Tyr 
465                 470                 475                 480 


Glu Gly Pro Lys Gly Gly Pro Gly Met Gln Glu Met Leu Tyr Pro Thr 
                485                 490                 495     


Ser Phe Leu Lys Ser Met Gly Leu Gly Lys Ala Cys Ala Leu Ile Thr 
            500                 505                 510         


Asp Gly Arg Phe Ser Gly Gly Thr Ser Gly Leu Ser Ile Gly His Val 
        515                 520                 525             


Ser Pro Glu Ala Ala Ser Gly Gly Ser Ile Gly Leu Ile Glu Asp Gly 
    530                 535                 540                 


Asp Leu Ile Ala Ile Asp Ile Pro Asn Arg Gly Ile Gln Leu Gln Val 
545                 550                 555                 560 


Ser Asp Ala Glu Leu Ala Ala Arg Arg Glu Ala Gln Asp Ala Arg Gly 
                565                 570                 575     


Asp Lys Ala Trp Thr Pro Lys Asn Arg Glu Arg Gln Val Ser Phe Ala 
            580                 585                 590         


Leu Arg Ala Tyr Ala Ser Leu Ala Thr Ser Ala Asp Lys Gly Ala Val 
        595                 600                 605             


Arg Asp Lys Ser Lys Leu Gly Gly 
    610                 615     


<210>  14
<211>  548
<212>  PRT
<213>  Lactococcus lactis

<400>  14

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser Arg Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Ser Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Lys Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Ser Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Pro Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Glu Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Asp Ala Pro Lys Val Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  15
<211>  349
<212>  PRT
<213>  Escherichia coli

<400>  15

Met Lys Ile Lys Ala Val Gly Ala Tyr Ser Ala Lys Gln Pro Leu Glu 
1               5                   10                  15      


Pro Met Asp Ile Thr Arg Arg Glu Pro Gly Pro Asn Asp Val Lys Ile 
            20                  25                  30          


Glu Ile Ala Tyr Cys Gly Val Cys His Ser Asp Leu His Gln Val Arg 
        35                  40                  45              


Ser Glu Trp Ala Gly Thr Val Tyr Pro Cys Val Pro Gly His Glu Ile 
    50                  55                  60                  


Val Gly Arg Val Val Ala Val Gly Asp Gln Val Glu Lys Tyr Ala Pro 
65                  70                  75                  80  


Gly Asp Leu Val Gly Val Gly Cys Ile Val Asp Ser Cys Lys His Cys 
                85                  90                  95      


Glu Glu Cys Glu Asp Gly Leu Glu Asn Tyr Cys Asp His Met Thr Gly 
            100                 105                 110         


Thr Tyr Asn Ser Pro Thr Pro Asp Glu Pro Gly His Thr Leu Gly Gly 
        115                 120                 125             


Tyr Ser Gln Gln Ile Val Val His Glu Arg Tyr Val Leu Arg Ile Arg 
    130                 135                 140                 


His Pro Gln Glu Gln Leu Ala Ala Val Ala Pro Leu Leu Cys Ala Gly 
145                 150                 155                 160 


Ile Thr Thr Tyr Ser Pro Leu Arg His Trp Gln Ala Gly Pro Gly Lys 
                165                 170                 175     


Lys Val Gly Val Val Gly Ile Gly Gly Leu Gly His Met Gly Ile Lys 
            180                 185                 190         


Leu Ala His Ala Met Gly Ala His Val Val Ala Phe Thr Thr Ser Glu 
        195                 200                 205             


Ala Lys Arg Glu Ala Ala Lys Ala Leu Gly Ala Asp Glu Val Val Asn 
    210                 215                 220                 


Ser Arg Asn Ala Asp Glu Met Ala Ala His Leu Lys Ser Phe Asp Phe 
225                 230                 235                 240 


Ile Leu Asn Thr Val Ala Ala Pro His Asn Leu Asp Asp Phe Thr Thr 
                245                 250                 255     


Leu Leu Lys Arg Asp Gly Thr Met Thr Leu Val Gly Ala Pro Ala Thr 
            260                 265                 270         


Pro His Lys Ser Pro Glu Val Phe Asn Leu Ile Met Lys Arg Arg Ala 
        275                 280                 285             


Ile Ala Gly Ser Met Ile Gly Gly Ile Pro Glu Thr Gln Glu Met Leu 
    290                 295                 300                 


Asp Phe Cys Ala Glu His Gly Ile Val Ala Asp Ile Glu Met Ile Arg 
305                 310                 315                 320 


Ala Asp Gln Ile Asn Glu Ala Tyr Glu Arg Met Leu Arg Gly Asp Val 
                325                 330                 335     


Lys Tyr Arg Phe Val Ile Asp Asn Arg Thr Leu Thr Asp 
            340                 345                 


