                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Acuitas Therapeutics Inc.
       Weissman, Drew
       Pardi, Norbert
       Tam, Ying
       Hope, Michael J.
 
<120>  NUCLEOSIDE-MODIFIED RNA FOR INDUCING AN ADAPTIVE IMMUNE RESPONSE

<130>  100177.410WO

<150>  US 62/413,837
<151>  2016-10-27

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  2544
<212>  DNA
<213>  Human immunodeficiency virus


<220>
<221>  misc_feature
<222>  (1507)..(1509)
<223>  n is a, c, g, t or u

<400>  1
atgagagtga agggcatccg gcgcaactgc cagcggtggt ggaagtgggg aatcatgctg       60

ctgggcatcc tgatgatctg caacgccgag cagctgtggg tcaccgtgta ctacggcgtg      120

cccgtgtgga aagaggccac caccaccctg ttctgcgcca gcgacgccaa gggccacgac      180

accgaggccc acaacgtgtg ggccacccac gcctgcgtgc ccaccgaccc caacccccag      240

gaaatcgtgc tggaaaacgt gaccgagaac ttcaacatgt ggaagaacaa catggtggaa      300

cagatgcacg aggacgtgat cagcctgtgg gaccagagcc tgaagccctg cgtgaagctg      360

acccccttct gcgtgaccct gaactgcacc gacgtgatga acaacgtgaa caccaccaca      420

aacagcagcg agcggatgat caagaagggc gagatcaaga actgcagctt caacatcaac      480

accaacatgc ggaacaaggt gcagaagaag cacgccctgt tctacaagct ggacgtggtg      540

cccatcgaca acaccagcta cagactgatc agctgcaaca ccagcgtgat cacccaggcc      600

tgccccaagg tgtccttcga gcccatcccc atccactact gcgcccccgc cggcttcgcc      660

atcctgaagt gccgggacaa gaagttcaac ggcaccggcc cctgcaccaa cgtgagcacc      720

gtgcagtgca cccacggcat cagacccgtg gtgagcaccc agctgctgtt caacggcagc      780

ctggccgagg aggacgtcgt gatcaagagc gccaacttca gcgacaacgc caagaccatc      840

ctggtgcagc tgaacgagac agtcgtgatc aactgcacca gacccggcaa caacacccgg      900

aaaagagtga cactgggccc cggccgggtg tactacacca ccggccagat catcggcgac      960

atccggaagg cccactgcaa cctgagcaga gccggctgga acaacaccct ggaacggatc     1020

gccatcaagc tgagagagca gttccagaac aagacaatcg ccttcaacca gagcagcgga     1080

ggcgaccccg agatcaccaa gatcagcttc aactgcggcg gcgagttctt ctactgcaac     1140

agcacacagc tgttcaacgg aacctggaac ggcacatggc tggacgtgaa gcagggcgac     1200

ggcaccatca ccctgccctg cagaatcaag cagatcatca acctgtggca ggaagtgggc     1260

aaggccatgt acgccccccc catcagcgga cagatccggt gcagcagcaa catcaccggc     1320

ctgctgctga ccagagacgg cggcaccagc aacgagacaa ccaccaccga gacattccgg     1380

cccggaggag gaaacatgaa ggacaactgg cgcagcgagc tgtaccggta caaagtgatc     1440

aagatcgagc ccctgggcgt ggcccccaca aaggcccgga gaagggtggt gcagcgcgag     1500

aaaagannng ccgtgggaat cggcgccgtg ttcctgggct tcctgggagc cgccggaagc     1560

acaatgggcg ccgccagcat gaccctgacc gtgcaggcca gacagctgct gagcggcatc     1620

gtgcagcagc agaccaacct gctgagagcc atcgaggcac agcagcagct gctgaaactg     1680

accgtgtggg gcatcaagca gctgcagaca agagtgctgg ccgtggaaag atacctgaag     1740

gaccagcagc tgctgggaat ctggggctgc agcggcaaac tgatctgcac caccaacgtg     1800

ccctggaaca ccagctggag caacaagagc atgcaccaga tttgggacaa catgacctgg     1860

atgcagtggg agagagagat cgacaactac acaggcctga tctacagcct gatcgaggaa     1920

agccagaacc agcaggaaaa gaacgaacag gaactgctgg ccctggacga gtgggccagc     1980

ctgtggaact ggttcgacat caccaagtgg ctgcggtaca tcaagatatt catcatcatc     2040

gtgggcggcc tgatcggcct gcggatcgtg ttcaccgtgc tgagcatcgt gaacagagtg     2100

cggaagggct acagccccct gagcttccag accagactgc ccacacccag aggccccgac     2160

agacccggcg gcatcgagga ggaaggcggc gacagagaca gggacggctc cggccccctc     2220

gtgaacggct tcctggccat catctgggtg gacctgcgga gcctgtgcct gttcagctac     2280

cacagactgc gggacctgct gctgatcgtg gccagaatcg tggaactgct gggcagaagg     2340

ggctgggagg ccctgaagta ctggtggaac ctgctgcagt actggtccca ggaactgaag     2400

aacagcgccg tgtccctgct gaacgccatc gccatcgccg tggccgaggg caccgacaga     2460

gtgatcgaag tgctgcagag agccggacgg gccatcctgc acatccccag aagaatccgg     2520

cagggcctgg aaagggccct gctg                                            2544


<210>  2
<211>  2960
<212>  DNA
<213>  Human immunodeficiency virus


<220>
<221>  misc_feature
<222>  (1653)..(1655)
<223>  n is a, c, g, t or u

<400>  2
ggaataaaag tctcaacaca acatatacaa aacaaacgaa tctcaagcaa tcaagcattc       60

tacttctatt gcagcaattt aaatcatttc ttttaaagca aaagcaattt tctgaaaatt      120

ttcaccattt acgaacgata gcgctgatga gagtgaaggg catccggcgc aactgccagc      180

ggtggtggaa gtggggaatc atgctgctgg gcatcctgat gatctgcaac gccgagcagc      240

tgtgggtcac cgtgtactac ggcgtgcccg tgtggaaaga ggccaccacc accctgttct      300

gcgccagcga cgccaagggc cacgacaccg aggcccacaa cgtgtgggcc acccacgcct      360

gcgtgcccac cgaccccaac ccccaggaaa tcgtgctgga aaacgtgacc gagaacttca      420

acatgtggaa gaacaacatg gtggaacaga tgcacgagga cgtgatcagc ctgtgggacc      480

agagcctgaa gccctgcgtg aagctgaccc ccttctgcgt gaccctgaac tgcaccgacg      540

tgatgaacaa cgtgaacacc accacaaaca gcagcgagcg gatgatcaag aagggcgaga      600

tcaagaactg cagcttcaac atcaacacca acatgcggaa caaggtgcag aagaagcacg      660

ccctgttcta caagctggac gtggtgccca tcgacaacac cagctacaga ctgatcagct      720

gcaacaccag cgtgatcacc caggcctgcc ccaaggtgtc cttcgagccc atccccatcc      780

actactgcgc ccccgccggc ttcgccatcc tgaagtgccg ggacaagaag ttcaacggca      840

ccggcccctg caccaacgtg agcaccgtgc agtgcaccca cggcatcaga cccgtggtga      900

gcacccagct gctgttcaac ggcagcctgg ccgaggagga cgtcgtgatc aagagcgcca      960

acttcagcga caacgccaag accatcctgg tgcagctgaa cgagacagtc gtgatcaact     1020

gcaccagacc cggcaacaac acccggaaaa gagtgacact gggccccggc cgggtgtact     1080

acaccaccgg ccagatcatc ggcgacatcc ggaaggccca ctgcaacctg agcagagccg     1140

gctggaacaa caccctggaa cggatcgcca tcaagctgag agagcagttc cagaacaaga     1200

caatcgcctt caaccagagc agcggaggcg accccgagat caccaagatc agcttcaact     1260

gcggcggcga gttcttctac tgcaacagca cacagctgtt caacggaacc tggaacggca     1320

catggctgga cgtgaagcag ggcgacggca ccatcaccct gccctgcaga atcaagcaga     1380

tcatcaacct gtggcaggaa gtgggcaagg ccatgtacgc cccccccatc agcggacaga     1440

tccggtgcag cagcaacatc accggcctgc tgctgaccag agacggcggc accagcaacg     1500

agacaaccac caccgagaca ttccggcccg gaggaggaaa catgaaggac aactggcgca     1560

gcgagctgta ccggtacaaa gtgatcaaga tcgagcccct gggcgtggcc cccacaaagg     1620

cccggagaag ggtggtgcag cgcgagaaaa gannngccgt gggaatcggc gccgtgttcc     1680

tgggcttcct gggagccgcc ggaagcacaa tgggcgccgc cagcatgacc ctgaccgtgc     1740

aggccagaca gctgctgagc ggcatcgtgc agcagcagac caacctgctg agagccatcg     1800

aggcacagca gcagctgctg aaactgaccg tgtggggcat caagcagctg cagacaagag     1860

tgctggccgt ggaaagatac ctgaaggacc agcagctgct gggaatctgg ggctgcagcg     1920

gcaaactgat ctgcaccacc aacgtgccct ggaacaccag ctggagcaac aagagcatgc     1980

accagatttg ggacaacatg acctggatgc agtgggagag agagatcgac aactacacag     2040

gcctgatcta cagcctgatc gaggaaagcc agaaccagca ggaaaagaac gaacaggaac     2100

tgctggccct ggacgagtgg gccagcctgt ggaactggtt cgacatcacc aagtggctgc     2160

ggtacatcaa gatattcatc atcatcgtgg gcggcctgat cggcctgcgg atcgtgttca     2220

ccgtgctgag catcgtgaac agagtgcgga agggctacag ccccctgagc ttccagacca     2280

gactgcccac acccagaggc cccgacagac ccggcggcat cgaggaggaa ggcggcgaca     2340

gagacaggga cggctccggc cccctcgtga acggcttcct ggccatcatc tgggtggacc     2400

tgcggagcct gtgcctgttc agctaccaca gactgcggga cctgctgctg atcgtggcca     2460

gaatcgtgga actgctgggc agaaggggct gggaggccct gaagtactgg tggaacctgc     2520

tgcagtactg gtcccaggaa ctgaagaaca gcgccgtgtc cctgctgaac gccatcgcca     2580

tcgccgtggc cgagggcacc gacagagtga tcgaagtgct gcagagagcc ggacgggcca     2640

tcctgcacat ccccagaaga atccggcagg gcctggaaag ggccctgctg taaactagta     2700

gtgactgact aggatctggt taccactaaa ccagcctcaa gaacacccga atggagtctc     2760

taagctacat aataccaact tacacttaca aaatgttgtc ccccaaaatg tagccattcg     2820

tatctgctcc taataaaaag aaagtttctt cacattctaa aaaaaaaaaa aaaaaaaaaa     2880

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     2940

aaaaaaaaaa aaaaaaaaac                                                 2960


<210>  3
<211>  565
<212>  PRT
<213>  Influenza virus

<400>  3

Met Lys Ala Asn Leu Leu Val Leu Leu Ser Ala Leu Ala Ala Ala Asp 
1               5                   10                  15      


Ala Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile 
    50                  55                  60                  


Ala Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Asp Pro Leu Leu Pro Val Arg Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn 
    130                 135                 140                 


Thr Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys Ser Ser Phe 
145                 150                 155                 160 


Tyr Arg Asn Leu Leu Trp Leu Thr Glu Lys Glu Gly Ser Tyr Pro Lys 
                165                 170                 175     


Leu Lys Asn Ser Tyr Val Asn Lys Lys Gly Lys Glu Val Leu Val Leu 
            180                 185                 190         


Trp Gly Ile His His Pro Pro Asn Ser Lys Glu Gln Gln Asn Leu Tyr 
        195                 200                 205             


Gln Asn Glu Asn Ala Tyr Val Ser Val Val Thr Ser Asn Tyr Asn Arg 
    210                 215                 220                 


Arg Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Asp Gln Ala 
225                 230                 235                 240 


Gly Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly Asp Thr Ile 
                245                 250                 255     


Ile Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Met Tyr Ala Phe Ala 
            260                 265                 270         


Leu Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met 
        275                 280                 285             


His Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Ser 
    290                 295                 300                 


Ser Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro 
305                 310                 315                 320 


Lys Tyr Val Arg Ser Ala Lys Leu Arg Met Val Thr Gly Leu Arg Asn 
                325                 330                 335     


Thr Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe 
            340                 345                 350         


Ile Glu Gly Gly Trp Thr Gly Met Ile Asp Gly Trp Tyr Gly Tyr His 
        355                 360                 365             


His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Gln Lys Ser Thr 
    370                 375                 380                 


Gln Asn Ala Ile Asn Gly Ile Thr Asn Lys Val Asn Thr Val Ile Glu 
385                 390                 395                 400 


Lys Met Asn Ile Gln Phe Thr Ala Val Gly Lys Glu Phe Asn Lys Leu 
                405                 410                 415     


Glu Lys Arg Met Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe Leu 
            420                 425                 430         


Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn Glu 
        435                 440                 445             


Arg Thr Leu Asp Phe His Asp Ser Asn Val Lys Asn Leu Tyr Glu Lys 
    450                 455                 460                 


Val Lys Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly Cys 
465                 470                 475                 480 


Phe Glu Phe Tyr His Lys Cys Asp Asn Glu Cys Met Glu Ser Val Arg 
                485                 490                 495     


Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ser Lys Leu Asn 
            500                 505                 510         


Arg Glu Lys Val Asp Gly Val Lys Leu Glu Ser Met Gly Ile Tyr Gln 
        515                 520                 525             


Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Leu Val 
    530                 535                 540                 


Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  4
<211>  1698
<212>  DNA
<213>  Influenza virus

<400>  4
atgaaggcaa acctactggt cctgttaagt gcacttgcag ctgcagatgc agacacaata       60

tgtataggct accatgcgaa caattcaacc gacactgttg acacagtact cgagaagaat      120

gtgacagtga cacactctgt taacctgctc gaagacagcc acaacggaaa actatgtaga      180

ttaaaaggaa tagccccact acaattgggg aaatgtaaca tcgccggatg gctcttggga      240

aacccagaat gcgacccact gcttccagtg agatcatggt cctacattgt agaaacacca      300

aactctgaga atggaatatg ttatccagga gatttcatcg actatgagga gctgagggag      360

caattgagct cagtgtcatc attcgaaaga ttcgaaatat ttcccaaaga aagctcatgg      420

cccaaccaca acacaaacgg agtaacggca gcatgctccc atgaggggaa aagcagtttt      480

tacagaaatt tgctatggct gacggagaag gagggctcat acccaaagct gaaaaattct      540

tatgtgaaca aaaaagggaa agaagtcctt gtactgtggg gtattcatca cccgcctaac      600

agtaaggaac aacagaatct ctatcagaat gaaaatgctt atgtctctgt agtgacttca      660

aattataaca ggagatttac cccggaaata gcagaaagac ccaaagtaag agatcaagct      720

gggaggatga actattactg gaccttgcta aaacccggag acacaataat atttgaggca      780

aatggaaatc taatagcacc aatgtatgct ttcgcactga gtagaggctt tgggtccggc      840

atcatcacct caaacgcatc aatgcatgag tgtaacacga agtgtcaaac acccctggga      900

gctataaaca gcagtctccc ttaccagaat atacacccag tcacaatagg agagtgccca      960

aaatacgtca ggagtgccaa attgaggatg gttacaggac taaggaacac tccgtccatt     1020

caatccagag gtctatttgg agccattgcc ggttttattg aagggggatg gactggaatg     1080

atagatggat ggtatggtta tcatcatcag aatgaacagg gatcaggcta tgcagcggat     1140

caaaaaagca cacaaaatgc cattaacggg attacaaaca aggtgaacac tgttatcgag     1200

aaaatgaaca ttcaattcac agctgtgggt aaagaattca acaaattaga aaaaaggatg     1260

gaaaatttaa ataaaaaagt tgatgatgga tttctggaca tttggacata taatgcagaa     1320

ttgttagttc tactggaaaa tgaaaggact ctggatttcc atgactcaaa tgtgaagaat     1380

ctgtatgaga aagtaaaaag ccaattaaag aataatgcca aagaaatcgg aaatggatgt     1440

tttgagttct accacaagtg tgacaatgaa tgcatggaaa gtgtaagaaa tgggacttat     1500

gattatccca aatattcaga agagtcaaag ttgaacaggg aaaaggtaga tggagtgaaa     1560

ttggaatcaa tggggatcta tcagattctg gcgatctact caactgtcgc cagttcactg     1620

gtgcttttgg tctccctggg ggcaatcagt ttctggatgt gttctaatgg atctttgcag     1680

tgcagaatat gcatctga                                                   1698


<210>  5
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthesized

<400>  5
atgaaggcga acctgctggt cctgctgagc gcgctggcgg cggcggacgc ggacacgatc       60

tgcatcggct accacgcgaa caacagcacc gacacggtcg acacggtcct cgagaagaac      120

gtgaccgtga cccacagcgt caacctgctc gaggacagcc acaacgggaa gctgtgcagg      180

ctcaagggca tcgccccgct gcagctgggg aagtgcaaca tcgccggctg gctcttgggg      240

aaccccgagt gcgacccgct gctcccggtg aggagctggt cctacatcgt ggagaccccg      300

aactcggaga acgggatctg ctacccgggg gacttcatcg actacgagga gctgagggag      360

cagttgagct cggtgtcgtc cttcgagagg ttcgagatct tccccaagga gagctcgtgg      420

cccaaccaca acaccaacgg ggtcacggcc gcgtgctccc acgaggggaa gagcagcttc      480

tacaggaact tgctgtggct gacggagaag gagggctcgt acccgaagct gaagaactcg      540

tacgtgaaca agaaggggaa ggaggtcctc gtactgtggg gcatccacca cccgccgaac      600

agcaaggagc agcagaacct ctaccagaac gagaacgcgt acgtctccgt ggtgacctcg      660

aactacaaca ggaggttcac cccggagatc gcggagaggc ccaaggtcag ggaccaggcc      720

gggaggatga actactactg gaccttgctg aagcccggcg acaccatcat cttcgaggcg      780

aacgggaacc tgatcgcacc gatgtacgcg ttcgcgctga gcaggggctt cgggtccggc      840

atcatcacct cgaacgcgtc catgcacgag tgcaacacga agtgccagac gcccctgggc      900

gcgatcaaca gcagcctccc gtaccagaac atccacccgg tcacgatcgg ggagtgcccc      960

aagtacgtca ggagcgccaa gttgaggatg gtgaccgggc tcaggaacac gccgtccatc     1020

cagtccaggg gcctgttcgg ggccatcgcc gggttcatcg aggggggctg gaccggcatg     1080

atcgacgggt ggtacgggta ccaccaccag aacgagcagg ggtcgggcta cgcggcggac     1140

cagaagagca cgcagaacgc catcaacggg atcacgaaca aggtgaacac ggtcatcgag     1200

aagatgaaca tccagttcac ggccgtgggg aaggagttca acaagttgga gaagaggatg     1260

gagaacttga acaagaaggt cgacgacggg ttcctggaca tctggacgta caacgcggag     1320

ttgttggtgc tgctggagaa cgagaggacg ctggacttcc acgactcgaa cgtgaagaac     1380

ctgtacgaga aggtgaagag ccagttgaag aacaacgcca aggagatcgg caacgggtgc     1440

ttcgagttct accacaagtg cgacaacgag tgcatggaga gcgtgaggaa cgggacgtac     1500

gactacccca agtactccga agagtcgaag ttgaacaggg agaaggtgga cggggtgaag     1560

ttggagtcga tggggatcta ccagatcctg gcgatctact cgacggtcgc cagctccctg     1620

gtgctgttgg tctccctggg ggcgatcagc ttctggatgt gctccaacgg gtcgttgcag     1680

tgcaggatct gcatctga                                                   1698


<210>  6
<211>  566
<212>  PRT
<213>  Influenza virus

<400>  6

Met Lys Ala Ile Leu Val Val Leu Leu Tyr Thr Phe Ala Thr Ala Asn 
1               5                   10                  15      


Ala Asp Thr Leu Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr 
            20                  25                  30          


Val Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn 
        35                  40                  45              


Leu Leu Glu Asp Lys His Asn Gly Lys Leu Cys Lys Leu Arg Gly Val 
    50                  55                  60                  


Ala Pro Leu His Leu Gly Lys Cys Asn Ile Ala Gly Trp Ile Leu Gly 
65                  70                  75                  80  


Asn Pro Glu Cys Glu Ser Leu Ser Thr Ala Ser Ser Trp Ser Tyr Ile 
                85                  90                  95      


Val Glu Thr Pro Ser Ser Asp Asn Gly Thr Cys Tyr Pro Gly Asp Phe 
            100                 105                 110         


Ile Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe 
        115                 120                 125             


Glu Arg Phe Glu Ile Phe Pro Lys Thr Ser Ser Trp Pro Asn His Asp 
    130                 135                 140                 


Ser Asn Lys Gly Val Thr Ala Ala Cys Pro His Ala Gly Ala Lys Ser 
145                 150                 155                 160 


Phe Tyr Lys Asn Leu Ile Trp Leu Val Lys Lys Gly Asn Ser Tyr Pro 
                165                 170                 175     


Lys Leu Ser Lys Ser Tyr Ile Asn Asp Lys Gly Lys Glu Val Leu Val 
            180                 185                 190         


Leu Trp Gly Ile His His Pro Ser Thr Ser Ala Asp Gln Gln Ser Leu 
        195                 200                 205             


Tyr Gln Asn Ala Asp Ala Tyr Val Phe Val Gly Ser Ser Arg Tyr Ser 
    210                 215                 220                 


Lys Lys Phe Lys Pro Glu Ile Ala Ile Arg Pro Lys Val Arg Gly Gln 
225                 230                 235                 240 


Glu Gly Arg Met Asn Tyr Tyr Trp Thr Leu Val Glu Pro Gly Asp Lys 
                245                 250                 255     


Ile Thr Phe Glu Ala Thr Gly Asn Leu Val Val Pro Arg Tyr Ala Phe 
            260                 265                 270         


Ala Met Glu Arg Asn Ala Gly Ser Gly Ile Ile Ile Ser Asp Thr Pro 
        275                 280                 285             


Val His Asp Cys Asn Thr Thr Cys Gln Thr Pro Lys Gly Ala Ile Asn 
    290                 295                 300                 


Thr Ser Leu Pro Phe Gln Asn Ile His Pro Ile Thr Ile Gly Lys Cys 
305                 310                 315                 320 


Pro Lys Tyr Val Lys Ser Thr Lys Leu Arg Leu Ala Thr Gly Leu Arg 
                325                 330                 335     


Asn Ile Pro Ser Ile Gln Ser Arg Gly Leu Phe Gly Ala Ile Ala Gly 
            340                 345                 350         


Phe Ile Glu Gly Gly Trp Thr Gly Met Val Asp Gly Trp Tyr Gly Tyr 
        355                 360                 365             


His His Gln Asn Glu Gln Gly Ser Gly Tyr Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Asn Ala Ile Asp Glu Ile Thr Asn Lys Val Asn Ser Val Ile 
385                 390                 395                 400 


Glu Lys Met Asn Thr Gln Phe Thr Ala Val Gly Lys Glu Phe Asn His 
                405                 410                 415     


Leu Glu Lys Arg Ile Glu Asn Leu Asn Lys Lys Val Asp Asp Gly Phe 
            420                 425                 430         


Leu Asp Ile Trp Thr Tyr Asn Ala Glu Leu Leu Val Leu Leu Glu Asn 
        435                 440                 445             


Glu Arg Thr Leu Asp Tyr His Asp Ser Asn Val Lys Asn Leu Tyr Glu 
    450                 455                 460                 


Lys Val Arg Ser Gln Leu Lys Asn Asn Ala Lys Glu Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Phe Tyr His Lys Cys Asp Asn Thr Cys Met Glu Ser Val 
                485                 490                 495     


Lys Asn Gly Thr Tyr Asp Tyr Pro Lys Tyr Ser Glu Glu Ala Lys Leu 
            500                 505                 510         


Asn Arg Glu Glu Ile Asp Gly Val Lys Leu Glu Ser Thr Arg Ile Tyr 
        515                 520                 525             


Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val 
    530                 535                 540                 


Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu 
545                 550                 555                 560 


Gln Cys Arg Ile Cys Ile 
                565     


<210>  7
<211>  1701
<212>  DNA
<213>  Influenza virus

<400>  7
atgaaagcaa tactagtagt tctgctatat acatttgcaa ccgcaaatgc agacacatta       60

tgtataggtt atcatgcgaa caattcaaca gacactgtag acacagtact agaaaagaat      120

gtaacagtaa cacactctgt taaccttcta gaagacaagc ataacgggaa actatgcaaa      180

ctaagagggg tagccccatt gcatttgggt aaatgtaaca ttgctggctg gatcctggga      240

aatccagagt gtgaatcact ctccacagca agctcatggt cctacattgt ggaaacacct      300

agttcagaca atggaacgtg ttacccagga gatttcatcg attatgagga gctaagagag      360

caattgagct cagtgtcatc atttgaaagg tttgagatat tccccaagac aagttcatgg      420

cccaatcatg actcgaacaa aggtgtaacg gcagcatgtc ctcatgctgg agcaaaaagc      480

ttctacaaaa atttaatatg gctagttaaa aaaggaaatt catacccaaa gctcagcaaa      540

tcctacatta atgataaagg gaaagaagtc ctcgtgctat ggggcattca ccatccatct      600

actagtgctg accaacaaag tctctatcag aatgcagatg catatgtttt tgtggggtca      660

tcaagataca gcaagaagtt caagccggaa atagcaataa gacccaaagt gaggggtcaa      720

gaagggagaa tgaactatta ctggacacta gtagagccgg gagacaaaat aacattcgaa      780

gcaactggaa atctagtggt accgagatat gcattcgcaa tggaaagaaa tgctggatct      840

ggtattatca tttcagatac accagtccac gattgcaata caacttgtca aacacccaag      900

ggtgctataa acaccagcct cccatttcag aatatacatc cgatcacaat tggaaaatgt      960

ccaaaatatg taaaaagcac aaaattgaga ctggccacag gattgaggaa tatcccgtct     1020

attcaatcta gaggcctatt tggggccatt gccggtttca ttgaaggggg gtggacaggg     1080

atggtagatg gatggtacgg ttatcaccat caaaatgagc aggggtcagg atatgcagcc     1140

gacctgaaga gcacacagaa tgccattgac gagattacta acaaagtaaa ttctgttatt     1200

gaaaagatga atacacagtt cacagcagta ggtaaagagt tcaaccacct ggaaaaaaga     1260

atagagaatt taaataaaaa agttgatgat ggtttcctgg acatttggac ttacaatgcc     1320

gaactgttgg ttctattgga aaatgaaaga actttggact accacgattc aaatgtgaag     1380

aacttatatg aaaaggtaag aagccagcta aaaaacaatg ccaaggaaat tggaaacggc     1440

tgctttgaat tttaccacaa atgcgataac acgtgcatgg aaagtgtcaa aaatgggact     1500

tatgactacc caaaatactc agaggaagca aaattaaaca gagaagaaat agatggggta     1560

aagctggaat caacaaggat ttaccagatt ttggcgatct attcaactgt cgccagttca     1620

ttggtactgg tagtctccct gggggcaatc agtttctgga tgtgctctaa tgggtctcta     1680

cagtgtagaa tatgtattta a                                               1701


<210>  8
<211>  1701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically synthisized

<400>  8
atgaaagcaa tactagtagt actgctatac acattcgcaa ccgcaaacgc agacacatta       60

tgcataggct accacgcgaa caactcaaca gacaccgtag acacagtact agaaaagaac      120

gtaacagtaa cacactccgt caacctccta gaagacaagc acaacgggaa actatgcaaa      180

ctaagagggg tagccccatt gcacttgggc aaatgcaaca tcgctggctg gatcctggga      240

aacccagagt gcgaatcact ctccacagca agctcatggt cctacatcgt ggaaacaccg      300

agctcagaca acggaacgtg ctacccagga gacttcatcg actacgagga gctaagagag      360

caattgagct cagtgtcatc attcgaaagg ttcgagatat tccccaagac aagctcatgg      420

cccaaccacg actcgaacaa aggcgtaacg gcagcatgcc cgcacgccgg agcaaaaagc      480

ttctacaaaa acttaatatg gctagtgaaa aaaggaaact catacccaaa gctcagcaaa      540

tcctacatca acgacaaagg gaaagaagtc ctcgtgctat ggggcatcca ccacccatcg      600

accagcgccg accaacaaag cctctaccag aacgcagacg catacgtgtt cgtggggtca      660

tcaagataca gcaagaagtt caagccggaa atagcaataa gacccaaagt gaggggccaa      720

gaagggagaa tgaactacta ctggacacta gtagagccgg gagacaaaat aacattcgaa      780

gcaaccggaa acctagtggt accgagatac gcattcgcaa tggaaagaaa cgccggatcc      840

ggcatcatca tatcagacac accagtccac gactgcaaca caacctgcca aacacccaag      900

ggcgcgataa acaccagcct cccattccag aacatacacc cgatcacaat cggaaaatgc      960

ccaaaatacg taaaaagcac aaaattgaga ctggccacag gattgaggaa tatcccgtcc     1020

atccaatcca gaggcctatt cggggccatc gccggcttca tcgaaggggg gtggacaggg     1080

atggtagatg gatggtacgg ttaccaccac caaaacgagc aggggtcagg atacgcagcc     1140

gacctgaaga gcacacagaa cgccatcgac gagatcacga acaaagtaaa ctccgtcatc     1200

gaaaagatga acacacagtt cacagcagta ggcaaagagt tcaaccacct ggaaaaaaga     1260

atagagaact taaacaaaaa agtcgacgac ggcttcctgg acatctggac ctacaacgcc     1320

gaactgttgg tcctattgga aaacgaaaga accttggact accacgactc aaacgtgaag     1380

aacttatacg aaaaggtaag aagccagcta aaaaacaacg ccaaggaaat cggaaacggc     1440

tgcttcgaat tctaccacaa atgcgacaac acgtgcatgg aaagcgtcaa aaacgggacg     1500

tacgactacc caaaatactc agaggaagca aaattaaaca gagaagaaat agacggggta     1560

aagctggaat caacaaggat ctaccagatc ttggcgatct actcaaccgt cgccagctca     1620

ttggtactgg tagtctccct gggggcaatc agtttctgga tgtgctccaa cgggtcccta     1680

cagtgcagaa tatgcatcta a                                               1701


