                         SEQUENCE LISTING

<110>  Actigen Ltd
 
<120>  Anti - PD-1 antibodies

<130>  69.15.126518/01

<150>  GB1618833.6
<151>  2016-11-08

<160>  100   

<170>  PatentIn version 3.5

<210>  1
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  1
gaggtgcagc tcgtgcagtc tggcgccgaa gtgaagaaac ccggctcctc cgtgaaggtg       60

tcctgcaagg cctccggcta caccttcacc agctactatg tgcattgggt ccgacaggcc      120

ccaggccagg gcctggaatg gatgggcggc atcatcccca tcttcggcac cgccaactac      180

gcccagaaat tccagggcag agtgaccatc accgccgacg agtccacctc caccgcctac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgcgc cagggacctg      300

cacggctact cctacggcta ccccggctat tggggccagg gcaccctggt caccgtgtcc      360

tct                                                                    363


<210>  2
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  2
gacatcgtga tgacccagtc ccccctgtcc ctgcccgtga ccctgggcca gcctgcctcc       60

atctcctgcc ggtcctccca gtccctggtg taccacgacg gcaacaccta cctgaactgg      120

ttccagcagc ggccaggcca gtcccctcgg cggctgatct acgaggtgtc caaccgggac      180

tctggcgtgc ccgacagatt ctccggctcc ggcagcgaca ccgacttcac cctgaagatc      240

agccgggtgg aagccgagga cgtgggcgtg tactactgca tgcagggcgc ctaccggccc      300

ctgaccttcg gccagggcac caaggtggaa atcaag                                336


<210>  3
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  3

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu His Gly Tyr Ser Tyr Gly Tyr Pro Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr His 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Asp Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ala Tyr Arg Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  5

Ser Tyr Tyr Val His 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  6

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  7

Asp Leu His Gly Tyr Ser Tyr Gly Tyr Pro Gly Tyr 
1               5                   10          


<210>  8
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  8

Arg Ser Ser Gln Ser Leu Val Tyr His Asp Gly Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  9

Glu Val Ser Asn Arg Asp Ser 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  10

Met Gln Gly Ala Tyr Arg Pro Leu Thr 
1               5                   


<210>  11
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  11

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  12

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  13
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  13

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  14
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  14

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  15
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  15

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  16

Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  17
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  17

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Asp Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  18

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  19
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  19
gaggtgcagc tcgtgcagtc tggcgccgaa gtgaagaaac ccggctcctc cgtgaaggtg       60

tcctgcaagg cctccggcta caccttcacc agctactatg tgcattgggt ccgacaggcc      120

ccaggccagg gcctggaatg gatgggcggc atcatcccca tcttcggcac cgccaactac      180

gcccagaaat tccagggcag agtgaccatc accgccgacg agtccaccga caccgcctac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgcgc cagggacctg      300

cacggctact cctacggcta ccccggctat tggggccagg gcaccctggt caccgtgtcc      360

tct                                                                    363


<210>  20
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  20
gacatcgtga tgacccagtc ccccctgtcc ctgcccgtga ccctgggcca gcctgcctcc       60

atctcctgcc ggtcctccca gtccctggtg taccacgacg ccaacaccta cctgaactgg      120

ttccagcagc ggccaggcca gtcccctcgg cggctgatct acgaggtgtc caaccgggac      180

tctggcgtgc ccgacagatt ctccggctcc ggcagcgaca ccgacttcac cctgaagatc      240

agccgggtgg aagccgagga cgtgggcgtg tactactgca tgcagggcgc ctaccggccc      300

ctgaccttcg gccagggcac caaggtggaa atcaag                                336


<210>  21
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  21

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu His Gly Tyr Ser Tyr Gly Tyr Pro Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  22
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  22

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr His 
            20                  25                  30          


Asp Ala Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Asp Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ala Tyr Arg Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  23

Ser Tyr Tyr Val His 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  24

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  25

Asp Leu His Gly Tyr Ser Tyr Gly Tyr Pro Gly Tyr 
1               5                   10          


<210>  26
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  26

Arg Ser Ser Gln Ser Leu Val Tyr His Asp Ala Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  27
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  27

Glu Val Ser Asn Arg Asp Ser 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  28

Met Gln Gly Ala Tyr Arg Pro Leu Thr 
1               5                   


<210>  29
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  29

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  30
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  30

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  31
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  31

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asp Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  32
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  32

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  33
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  33

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  34

Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  35
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  35

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Asp Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  36

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  37
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  37
gaggtgcagc tcgtgcagtc tggcgccgaa gtgaagaaac ccggctcctc cgtgaaggtg       60

tcctgcaagg cctccggcta caccttcacc agctactatg tgcattgggt ccgacaggcc      120

ccaggccagg gcctggaatg gatgggcggc atcatcccca tcttcggcac cgccaactac      180

gcccagaaat tccagggcag agtgaccatc accgccgacg agtccatctc caccgcctac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgcgc cagggacctg      300

cacggctact cctacggcta ccccggctat tggggccagg gcaccctggt caccgtgtcc      360

tct                                                                    363


<210>  38
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  38
gacatcgtga tgacccagtc ccccctgtcc ctgcccgtga ccctgggcca gcctgcctcc       60

atctcctgcc ggtcctccca gtccctggtg taccacgacg ccaacaccta cctgaactgg      120

ttccagcagc ggccaggcca gtcccctcgg cggctgatct acgaggtgtc caaccgggac      180

tctggcgtgc ccgacagatt ctccggctcc ggcagcgaca ccgacttcac cctgaagatc      240

agccgggtgg aagccgagga cgtgggcgtg tactactgca tgcagggcgc ctaccggccc      300

ctgaccttcg gccagggcac caaggtggaa atcaag                                336


<210>  39
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  39

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu His Gly Tyr Ser Tyr Gly Tyr Pro Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  40
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  40

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr His 
            20                  25                  30          


Asp Ala Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Asp Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ala Tyr Arg Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  41
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  41

Ser Tyr Tyr Val His 
1               5   


<210>  42
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  42

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  43

Asp Leu His Gly Tyr Ser Tyr Gly Tyr Pro Gly Tyr 
1               5                   10          


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  44

Arg Ser Ser Gln Ser Leu Val Tyr His Asp Ala Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  45

Glu Val Ser Asn Arg Asp Ser 
1               5           


<210>  46
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  46

Met Gln Gly Ala Tyr Arg Pro Leu Thr 
1               5                   


<210>  47
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  47

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  48
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  48

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  49
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  49

Arg Val Thr Ile Thr Ala Asp Glu Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  50
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  50

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  51
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  51

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  52
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  52

Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  53
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  53

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Asp Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  54

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  55
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  55
gaggtgcagc tcgtgcagtc tggcgccgaa gtgaagaaac ccggctcctc cgtgaaggtg       60

tcctgcaagg cctccggcta caccttcacc agctactatg tgcattgggt ccgacaggcc      120

ccaggccagg gcctggaatg gatgggcggc atcatcccca tcttcggcac cgccaactac      180

gcccagaaat tccagggcag agtgaccatc accgccgacg agtccatctc caccgcctac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgcgc cagggacctg      300

cacggctact cctacggcta ccccggctat tggggccagg gcaccctggt caccgtgtcc      360

tct                                                                    363


<210>  56
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  56
gacatcgtga tgacccagtc ccccctgtcc ctgcccgtga ccctgggcca gcctgcctcc       60

atctcctgcc ggtcctccca gtccctggtg tactccgacg ccaacaccta cctgaactgg      120

ttccagcagc ggcctggcca gtcccctcgg cggctgatct acgaggtgtc caaccgcgag      180

tctggcgtgc ccgacagatt ctccggctcc ggctctgcca ccgacttcac cctgaagatc      240

agccgggtgg aagccgagga cgtgggcgtg tactactgca tgcagggcac ccagctgccc      300

ctgaccttcg gcggaggcac caaggtggaa atcaag                                336


<210>  57
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  57

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu His Gly Tyr Ser Tyr Gly Tyr Pro Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  58
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  58

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Ala Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr Gln Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  59
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  59

Ser Tyr Tyr Val His 
1               5   


<210>  60
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  60

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  61

Asp Leu His Gly Tyr Ser Tyr Gly Tyr Pro Gly Tyr 
1               5                   10          


<210>  62
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  62

Arg Ser Ser Gln Ser Leu Val Tyr Ser Asp Ala Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  63

Glu Val Ser Asn Arg Glu Ser 
1               5           


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  64

Met Gln Gly Thr Gln Leu Pro Leu Thr 
1               5                   


<210>  65
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  65

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr 
            20                  25                  30  


<210>  66
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  66

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  67
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  67

Arg Val Thr Ile Thr Ala Asp Glu Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  68

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  69
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  69

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys 
            20              


<210>  70
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  70

Trp Phe Gln Gln Arg Pro Gly Gln Ser Pro Arg Arg Leu Ile Tyr 
1               5                   10                  15  


<210>  71
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  71

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Ala Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  72

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  73
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa can be any amino acid

<400>  73

Arg Ser Ser Gln Ser Leu Val Tyr Xaa Asp Xaa Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  74
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is H or S

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is G or A

<400>  74

Arg Ser Ser Gln Ser Leu Val Tyr Xaa Asp Xaa Asn Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be any amino acid

<400>  75

Glu Val Ser Asn Arg Xaa Ser 
1               5           


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be D or E

<400>  76

Glu Val Ser Asn Arg Xaa Ser 
1               5           


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be any amino acid

<400>  77

Met Gln Gly Xaa Xaa Xaa Pro Leu Thr 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be A or T

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be Y or Q

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be R or L

<400>  78

Met Gln Gly Xaa Xaa Xaa Pro Leu Thr 
1               5                   


<210>  79
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa can be any amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa can be any amino acid

<400>  79

Arg Val Thr Ile Thr Ala Asp Glu Ser Xaa Xaa Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  80
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa can be T or I

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa can be S or D

<400>  80

Arg Val Thr Ile Thr Ala Asp Glu Ser Xaa Xaa Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  81
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  81

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  82
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  82

Ala Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
            20                  25                  30          


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp 
                85                  90                  95      


Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110     


<210>  83
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  83

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Asp Cys Lys Ala Ser Gly Ile Thr Phe Ser Asn Ser 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Tyr Asp Gly Ser Lys Arg Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Asp Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 
        115                 120                 125             


Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
    130                 135                 140                 


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
145                 150                 155                 160 


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
                165                 170                 175     


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 
            180                 185                 190         


Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 
        195                 200                 205             


Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 
    210                 215                 220                 


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Ala Val Ser Asn Lys Gly Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  84
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  84

Ala Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser 
            20                  25                  30          


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
        35                  40                  45              


Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Ser Asn Trp 
                85                  90                  95      


Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Ala 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  85
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  85

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu His Gly Tyr Ser Tyr Gly Tyr Pro Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  86
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  86

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr His 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Asp Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ala Tyr Arg Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  87
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  87
gaggtgcagc tcgtgcagtc tggcgccgaa gtgaagaaac ccggctcctc cgtgaaggtg       60

tcctgcaagg cctccggcta caccttcacc agctactatg tgcattgggt ccgacaggcc      120

ccaggccagg gcctggaatg gatgggcggc atcatcccca tcttcggcac cgccaactac      180

gcccagaaat tccagggcag agtgaccatc accgccgacg agtccacctc caccgcctac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgcgc cagggacctg      300

cacggctact cctacggcta ccccggctat tggggccagg gcaccctggt caccgtgtcc      360

tctgcctcca ccaagggccc cagcgtgttc cccctggccc cctgcagcag aagcaccagc      420

gagagcaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      480

agctggaaca gcggcgccct gaccagcggc gtgcacacct tccctgccgt gctgcagagc      540

agcggcctgt acagcctgag cagcgtggtg accgtgccca gcagcaactt cggcacccag      600

acctacacct gcaacgtgga ccacaagccc agcaacacca aggtggacaa gaccgtggag      660

agaaagtgct gcgtggagtg ccctccctgc cccgctcccc ctgtggctgg ccccagcgtg      720

ttcctgttcc ctcccaagcc caaggacacc ctgatgatca gcagaacccc cgaggtgacc      780

tgcgtggtcg tggacgtgag ccacgaggac cccgaggtgc agttcaactg gtacgtggac      840

ggcgtggagg tgcacaacgc caagaccaag cccagagagg agcagttcaa cagcaccttc      900

agagtggtga gcgtgctgac cgtggtgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtga gcaacaaggg cctgcccgcc cccatcgaga agaccatcag caagaccaag     1020

ggccagccca gagagcccca ggtgtacacc ctgcccccta gcagagagga gatgaccaag     1080

aaccaggtga gcctgacctg cctggtgaag ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca acggccagcc cgagaacaac tacaagacca caccccccat gctggacagc     1200

gacggcagct tcttcctgta cagcaagctg accgtggaca agagcagatg gcagcagggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagagc     1320

ctgagcctga gccccggcaa g                                               1341


<210>  88
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  88
gacatcgtga tgacccagtc ccccctgtcc ctgcccgtga ccctgggcca gcctgcctcc       60

atctcctgcc ggtcctccca gtccctggtg taccacgacg gcaacaccta cctgaactgg      120

ttccagcagc ggccaggcca gtcccctcgg cggctgatct acgaggtgtc caaccgggac      180

tctggcgtgc ccgacagatt ctccggctcc ggcagcgaca ccgacttcac cctgaagatc      240

agccgggtgg aagccgagga cgtgggcgtg tactactgca tgcagggcgc ctaccggccc      300

ctgaccttcg gccagggcac caaggtggaa atcaagcgaa ccgtggccgc tcccagcgtg      360

ttcatcttcc ctcccagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgcctg      420

ctgaacaact tctaccccag agaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

agcggcaaca gccaggagag cgtgaccgag caggacagca aggacagcac ctacagcctg      540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      600

gtgacccacc agggcctgag cagccccgtg accaagagct tcaacagagg cgagtgc         657


<210>  89
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  89

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu His Gly Tyr Ser Tyr Gly Tyr Pro Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  90
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  90

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr His 
            20                  25                  30          


Asp Ala Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Asp Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ala Tyr Arg Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  91
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  91
gaagtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ccggctcctc cgtgaaggtg       60

tcctgcaagg cctccggcta cacctttacc agctactacg tgcactgggt gcgacaggcc      120

cctggacagg gcctggaatg gatgggcggc atcatcccca tcttcggcac cgccaactac      180

gcccagaaat tccagggcag agtgaccatc accgccgacg agtctaccga caccgcctac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actattgcgc cagagatctg      300

cacggctact cctacggcta ccccggctat tggggacagg gcaccctcgt gacagtgtcc      360

tccgcttcta ccaagggccc cagcgtgttc cctctggccc cttgctccag atccacctcc      420

gagtctacag ccgccctggg ctgcctcgtg aaggactact ttcctgagcc cgtgaccgtg      480

tcttggaact ctggcgctct gaccagcggc gtgcacacct tccctgctgt gctgcagtcc      540

tccggcctgt acagcctgtc cagcgtcgtg actgtgccct cctccaactt tggcacccag      600

acctacacct gtaacgtgga ccacaagccc tccaacacca aagtggacaa gaccgtggaa      660

cggaagtgct gcgtggaatg ccccccttgt cctgcccctc ctgtggctgg cccttccgtg      720

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc tgaagtgacc      780

tgcgtggtgg tggatgtgtc ccacgaggac cccgaggtgc agttcaattg gtacgtggac      840

ggcgtggaag tgcacaatgc caagaccaag cccagagagg aacagttcaa cagcaccttc      900

cgggtggtgt ccgtgctgac cgtggtgcat caggactggc tgaacggcaa agagtacaag      960

tgcaaagtgt ccaacaaggg cctgcctgcc cccatcgaaa agaccatctc taagaccaag     1020

ggacagcccc gcgagcctca ggtgtacaca ctgcccccta gccgggaaga gatgaccaag     1080

aaccaggtgt ccctgacctg tctcgtgaaa ggcttctacc cttccgatat cgccgtggaa     1140

tgggagtcca acggccagcc cgagaacaac tacaagacca ccccccccat gctggactcc     1200

gatggctcat tcttcctgta ctccaagctg actgtggaca agtcccggtg gcagcagggc     1260

aacgtgttct cctgctccgt gatgcacgag gccctgcaca accactacac ccagaagtcc     1320

ctgtccctga gccccggcaa a                                               1341


<210>  92
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  92
gacatcgtga tgacccagtc ccccctgtct ctgcctgtga ccctgggaca gcctgcctcc       60

atctcctgca gatcctccca gtccctggtg taccacgacg ccaacaccta cctgaactgg      120

ttccagcagc ggcctggcca gtctcccaga cggctgatct acgaggtgtc caaccgggac      180

tccggcgtgc ccgatagatt ctccggctct ggctccgaca ccgacttcac cctgaagatc      240

tcccgggtgg aagccgagga cgtgggcgtg tactactgta tgcagggcgc ctaccggccc      300

ctgacctttg gccagggaac aaaggtggaa atcaagcgga ccgtggccgc tccctccgtg      360

ttcatcttcc caccttccga cgagcagctg aagtccggca ccgcttctgt cgtgtgcctg      420

ctgaacaact tctacccccg cgaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

tccggcaact cccaggaatc cgtgaccgag caggactcca aggacagcac ctactccctg      540

tcctccaccc tgaccctgtc caaggccgac tacgagaagc acaaggtgta cgcctgcgaa      600

gtgacccacc agggcctgtc tagccccgtg accaagtctt tcaaccgggg cgagtgc         657


<210>  93
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  93

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu His Gly Tyr Ser Tyr Gly Tyr Pro Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  94
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  94

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr His 
            20                  25                  30          


Asp Ala Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Asp Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Ala Tyr Arg Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  95
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  95
gaggtgcagc tcgtgcagtc tggcgccgaa gtgaagaaac ccggctcctc cgtgaaggtg       60

tcctgcaagg cctccggcta caccttcacc agctactatg tgcattgggt ccgacaggcc      120

ccaggccagg gcctggaatg gatgggcggc atcatcccca tcttcggcac cgccaactac      180

gcccagaaat tccagggcag agtgaccatc accgccgacg agtccatctc caccgcctac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgcgc cagggacctg      300

cacggctact cctacggcta ccccggctat tggggccagg gcaccctggt caccgtgtcc      360

tctgcctcca ccaagggccc cagcgtgttc cccctggccc cctgcagcag aagcaccagc      420

gagagcaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      480

agctggaaca gcggcgccct gaccagcggc gtgcacacct tccctgccgt gctgcagagc      540

agcggcctgt acagcctgag cagcgtggtg accgtgccca gcagcaactt cggcacccag      600

acctacacct gcaacgtgga ccacaagccc agcaacacca aggtggacaa gaccgtggag      660

agaaagtgct gcgtggagtg ccctccctgc cccgctcccc ctgtggctgg ccccagcgtg      720

ttcctgttcc ctcccaagcc caaggacacc ctgatgatca gcagaacccc cgaggtgacc      780

tgcgtggtcg tggacgtgag ccacgaggac cccgaggtgc agttcaactg gtacgtggac      840

ggcgtggagg tgcacaacgc caagaccaag cccagagagg agcagttcaa cagcaccttc      900

agagtggtga gcgtgctgac cgtggtgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtga gcaacaaggg cctgcccgcc cccatcgaga agaccatcag caagaccaag     1020

ggccagccca gagagcccca ggtgtacacc ctgcccccta gcagagagga gatgaccaag     1080

aaccaggtga gcctgacctg cctggtgaag ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca acggccagcc cgagaacaac tacaagacca caccccccat gctggacagc     1200

gacggcagct tcttcctgta cagcaagctg accgtggaca agagcagatg gcagcagggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagagc     1320

ctgagcctga gccccggcaa g                                               1341


<210>  96
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  96
gacatcgtga tgacccagtc ccccctgtcc ctgcccgtga ccctgggcca gcctgcctcc       60

atctcctgcc ggtcctccca gtccctggtg taccacgacg ctaacaccta cctgaactgg      120

ttccagcagc ggccaggcca gtcccctcgg cggctgatct acgaggtgtc caaccgggac      180

tctggcgtgc ccgacagatt ctccggctcc ggcagcgaca ccgacttcac cctgaagatc      240

agccgggtgg aagccgagga cgtgggcgtg tactactgca tgcagggcgc ctaccggccc      300

ctgaccttcg gccagggcac caaggtggaa atcaagcgaa ccgtggccgc tcccagcgtg      360

ttcatcttcc ctcccagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgcctg      420

ctgaacaact tctaccccag agaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

agcggcaaca gccaggagag cgtgaccgag caggacagca aggacagcac ctacagcctg      540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      600

gtgacccacc agggcctgag cagccccgtg accaagagct tcaacagagg cgagtgc         657


<210>  97
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  97

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Val His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu His Gly Tyr Ser Tyr Gly Tyr Pro Gly Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 


Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  98
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  98

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Ser 
            20                  25                  30          


Asp Ala Asn Thr Tyr Leu Asn Trp Phe Gln Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Arg Arg Leu Ile Tyr Glu Val Ser Asn Arg Glu Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Ala Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly 
                85                  90                  95      


Thr Gln Leu Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  99
<211>  1341
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  99
gaggtgcagc tcgtgcagtc tggcgccgaa gtgaagaaac ccggctcctc cgtgaaggtg       60

tcctgcaagg cctccggcta caccttcacc agctactatg tgcattgggt ccgacaggcc      120

ccaggccagg gcctggaatg gatgggcggc atcatcccca tcttcggcac cgccaactac      180

gcccagaaat tccagggcag agtgaccatc accgccgacg agtccatctc caccgcctac      240

atggaactgt cctccctgcg gagcgaggac accgccgtgt actactgcgc cagggacctg      300

cacggctact cctacggcta ccccggctat tggggccagg gcaccctggt caccgtgtcc      360

tctgcctcca ccaagggccc cagcgtgttc cccctggccc cctgcagcag aagcaccagc      420

gagagcaccg ccgccctggg ctgcctggtg aaggactact tccccgagcc cgtgaccgtg      480

agctggaaca gcggcgccct gaccagcggc gtgcacacct tccctgccgt gctgcagagc      540

agcggcctgt acagcctgag cagcgtggtg accgtgccca gcagcaactt cggcacccag      600

acctacacct gcaacgtgga ccacaagccc agcaacacca aggtggacaa gaccgtggag      660

agaaagtgct gcgtggagtg ccctccctgc cccgctcccc ctgtggctgg ccccagcgtg      720

ttcctgttcc ctcccaagcc caaggacacc ctgatgatca gcagaacccc cgaggtgacc      780

tgcgtggtcg tggacgtgag ccacgaggac cccgaggtgc agttcaactg gtacgtggac      840

ggcgtggagg tgcacaacgc caagaccaag cccagagagg agcagttcaa cagcaccttc      900

agagtggtga gcgtgctgac cgtggtgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtga gcaacaaggg cctgcccgcc cccatcgaga agaccatcag caagaccaag     1020

ggccagccca gagagcccca ggtgtacacc ctgcccccta gcagagagga gatgaccaag     1080

aaccaggtga gcctgacctg cctggtgaag ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca acggccagcc cgagaacaac tacaagacca caccccccat gctggacagc     1200

gacggcagct tcttcctgta cagcaagctg accgtggaca agagcagatg gcagcagggc     1260

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagagc     1320

ctgagcctga gccccggcaa g                                               1341


<210>  100
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antibody sequence

<400>  100
gacatcgtga tgacccagtc ccccctgtcc ctgcccgtga ccctgggcca gcctgcctcc       60

atctcctgcc ggtcctccca gtccctggtg tactccgacg ccaacaccta cctgaactgg      120

ttccagcagc ggcctggcca gtcccctcgg cggctgatct acgaggtgtc caaccgcgag      180

tctggcgtgc ccgacagatt ctccggctcc ggctctgcca ccgacttcac cctgaagatc      240

agccgggtgg aagccgagga cgtgggcgtg tactactgca tgcagggcac ccagctgccc      300

ctgaccttcg gcggaggcac caaggtggaa atcaagcgaa ccgtggccgc tcccagcgtg      360

ttcatcttcc ctcccagcga cgagcagctg aagagcggca ccgccagcgt ggtgtgcctg      420

ctgaacaact tctaccccag agaggccaag gtgcagtgga aggtggacaa cgccctgcag      480

agcggcaaca gccaggagag cgtgaccgag caggacagca aggacagcac ctacagcctg      540

agcagcaccc tgaccctgag caaggccgac tacgagaagc acaaggtgta cgcctgcgag      600

gtgacccacc agggcctgag cagccccgtg accaagagct tcaacagagg cgagtgc         657


