                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
 
<120>  MODULATORS OF HUMAN KAI1 METASTASIS SUPPRESSOR GENE, METHODS AND 
       USES THEREOF

<130>  2510284

<150>  US 62/423,530
<151>  2016-11-17

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  801
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Sense KAI1 ORF

<400>  1
atgggctcag cctgtatcaa agtcaccaaa tactttctct tcctcttcaa cttgatcttc       60

tttatcctgg gcgcagtgat cctgggcttc ggggtgtgga tcctggccga caagagcagt      120

ttcatctctg tcctgcaaac ctcctccagc tcgcttagga tgggggccta tgtcttcatc      180

ggcgtggggg cagtcactat gctcatgggc ttcctgggct gcatcggcgc cgtcaacgag      240

gtccgctgcc tgctggggct gtactttgct ttcctgctcc tgatcctcat tgcccaggtg      300

acggccgggg ccctcttcta cttcaacatg ggcaagctga agcaggagat gggcggcatc      360

gtgactgagc tcattcgaga ctacaacagc agtcgcgagg acagcctgca ggatgcctgg      420

gactacgtgc aggctcaggt gaagtgctgc ggctgggtca gcttctacaa ctggacagac      480

aacgctgagc tcatgaatcg ccctgaggtc acctacccct gttcctgcga agtcaagggg      540

gaagaggaca acagcctttc tgtgaggaag ggcttctgcg aggcccccgg caacaggacc      600

cagagtggca accaccctga ggactggcct gtgtaccagg agggctgcat ggagaaggtg      660

caggcgtggc tgcaggagaa cctgggcatc atcctcggcg tgggcgtggg tgtggccatc      720

atcgagctcc tggggatggt cctgtccatc tgcttgtgcc ggcacgtcca ttccgaagac      780

tacagcaagg tccccaagta c                                                801


<210>  2
<211>  801
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Anti-Sense KAI1 ORF

<400>  2
gtacttgggg accttgctgt agtcttcgga atggacgtgc cggcacaagc agatggacag       60

gaccatcccc aggagctcga tgatggccac acccacgccc acgccgagga tgatgcccag      120

gttctcctgc agccacgcct gcaccttctc catgcagccc tcctggtaca caggccagtc      180

ctcagggtgg ttgccactct gggtcctgtt gccgggggcc tcgcagaagc ccttcctcac      240

agaaaggctg ttgtcctctt cccccttgac ttcgcaggaa caggggtagg tgacctcagg      300

gcgattcatg agctcagcgt tgtctgtcca gttgtagaag ctgacccagc cgcagcactt      360

cacctgagcc tgcacgtagt cccaggcatc ctgcaggctg tcctcgcgac tgctgttgta      420

gtctcgaatg agctcagtca cgatgccgcc catctcctgc ttcagcttgc ccatgttgaa      480

gtagaagagg gccccggccg tcacctgggc aatgaggatc aggagcagga aagcaaagta      540

cagccccagc aggcagcgga cctcgttgac ggcgccgatg cagcccagga agcccatgag      600

catagtgact gcccccacgc cgatgaagac ataggccccc atcctaagcg agctggagga      660

ggtttgcagg acagagatga aactgctctt gtcggccagg atccacaccc cgaagcccag      720

gatcactgcg cccaggataa agaagatcaa gttgaagagg aagagaaagt atttggtgac      780

tttgatacag gctgagccca t                                                801


<210>  3
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA non-silencing

<400>  3
atctcgcttg ggcgagagta ag                                                22


<210>  4
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA-1, directed against KAI1 as-lncRNA (T for U)

<400>  4
tgctgttgac agtgagcgca caactcatgg gtactctcgt tagtgaagcc acagatgtaa       60

cgagagtacc catgagttgt gtgcctactg cctcgga                                97


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  target-like sequence (the actual sequence is present in the 792 
       bp long KAI1 as-lncRNA)

<400>  5
acaactcatg ggtactctcg t                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  inverted repeat (guide) sequence of the target-like sequence of 
       SEQ ID NO. 5

<400>  6
acgagagtac ccatgagttg t                                                 21


<210>  7
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hairpin loop within shRNA-1

<400>  7
tagtgaagcc acagatgta                                                    19


<210>  8
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Flanking sequence within shRNA-1

<400>  8
tgctgttgac agtgagcgc                                                    19


<210>  9
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Flanking sequence within shRNA-1

<400>  9
gtgcctactg cctcgga                                                      17


<210>  10
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used to amplify shRNA-1

<400>  10
cagaaggctc gagaaggtat attgctgttg acagtgagcg                             40


<210>  11
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used to amplify shRNA-1

<400>  11
ctaaagtagc cccttgaatt ccgaggcagt aggca                                  35


<210>  12
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 ORF Forward

<400>  12
atgggctcag cctgtatcaa ag                                                22


<210>  13
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 ORF Reverse

<400>  13
tcagtacttg gggaccttgc tg                                                22


<210>  14
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AgeI-SnaBI-EcoRI adapter upper strand

<400>  14
ccggtgtacg tacgtacg                                                     18


<210>  15
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' to 3' EcoRI-SnaBI-AgeI adapter lower strand

<400>  15
aattcgtacg taca                                                         14


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer used for determining the orientation of the insert (sense 
       or antisense) of KAI1 ORF sequence into TRIPZ

<400>  16
cgtatgtcga ggtaggcgtg                                                   20


<210>  17
<211>  78
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  78 bp sequence mutual to all four transcripts

<400>  17
ccagccucag guccugaguc acaggcuuga gcugccccag cuugccugga cuggccccug       60

gggaaguagc ccagaaca                                                     78


<210>  18
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1- shRNA-1 upper (for insertion into SHC203)

<400>  18
cccggacaac tcatgggtac tctcgtctcg agacgagagt acccatgagt tgttttttgt       60


<210>  19
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1- shRNA-1 lower (for insertion into SHC203)

<400>  19
aacaaaaaac aactcatggg tactctcgtc tcgagacgag agtacccatg agttgtccgg       60


<210>  20
<211>  1198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Sense KAI1 promoter-enhancer 1198

<400>  20
gtcagctgca caggtgaatg cccctggtca ttaaccaggt aatctgcctg aggctagtcc       60

tctggagcct gggagggcag agggctggga cgcagggtgg gcaccgcagc cacctagaga      120

gctcttgcag cccacctcaa ttttgggcca ctttttcttc agggagaaag ccagctttga      180

gggcttaggc ccacagcccc tcctgccact attctcatca acccacacct cctccctcac      240

ctcaggcagc tgctgggcac tgccccagca ctggttgttc tgggctactt ccccaggggc      300

cagtccaggc aagctggggc agctcaagcc tgtgactcag gacctgaggc tggatcccgc      360

tcacgcccgc ctccatgaga ttcagagccc tcgacttccc ttctctgagc cttaaactgc      420

gcattagtaa aataggcgca acgagagtac ccatgagttg tgggaattca agggctagaa      480

ctgtattcag cgcttggcat agagcctggc ccctggcaag gattcaatca atggtagtca      540

gtattttcaa aaagttcctg ggcccaggcc gcctcctgat agaggccccg acttaggaca      600

caaaccgctc ccacgccgtt ccccggcggc acccggatac acccgccctg gaatgccagc      660

gtgggggccc cagggctacc cgcccgagat gagaggggca gggcagggca ggattaggaa      720

ggcgctgagc ccaggctggt gcggggaggg gcgtggcctc accctactag ggccggggga      780

tggggtgggc tcgaaggaga aagtgaagga ggcgggggcg ctgggagggc ccgggaggag      840

accgggagga cgaggtaggc gggagctggg cgggaccgtt aggcagcgcc gtgagtggac      900

agggctggag cggggcgggc ttaatcccca gtgtaacctg ggggcggggc tgccgggata      960

gaggagagac tccgtagcgg ggcggggcct cagctccagc tgggcccggg ggcgaggctg     1020

gttggggtac ggccatagtg ggcggggcct ggccggcggg agcgcaccgc cttcccaaag     1080

ggctcggggg cggggccggc ggagggggcg tgtcttctgg gggcggggcc tgccgagtcc     1140

gcggcgttcc ccggctgcag ccgggagggg gccgaggagt gactgagccc cgggctgt       1198


<210>  21
<211>  1198
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Anti-Sense KAI1 promoter-enhancer 1198

<400>  21
acagcccggg gctcagtcac tcctcggccc cctcccggct gcagccgggg aacgccgcgg       60

actcggcagg ccccgccccc agaagacacg ccccctccgc cggccccgcc cccgagccct      120

ttgggaaggc ggtgcgctcc cgccggccag gccccgccca ctatggccgt accccaacca      180

gcctcgcccc cgggcccagc tggagctgag gccccgcccc gctacggagt ctctcctcta      240

tcccggcagc cccgccccca ggttacactg gggattaagc ccgccccgct ccagccctgt      300

ccactcacgg cgctgcctaa cggtcccgcc cagctcccgc ctacctcgtc ctcccggtct      360

cctcccgggc cctcccagcg cccccgcctc cttcactttc tccttcgagc ccaccccatc      420

ccccggccct agtagggtga ggccacgccc ctccccgcac cagcctgggc tcagcgcctt      480

cctaatcctg ccctgccctg cccctctcat ctcgggcggg tagccctggg gcccccacgc      540

tggcattcca gggcgggtgt atccgggtgc cgccggggaa cggcgtggga gcggtttgtg      600

tcctaagtcg gggcctctat caggaggcgg cctgggccca ggaacttttt gaaaatactg      660

actaccattg attgaatcct tgccaggggc caggctctat gccaagcgct gaatacagtt      720

ctagcccttg aattcccaca actcatgggt actctcgttg cgcctatttt actaatgcgc      780

agtttaaggc tcagagaagg gaagtcgagg gctctgaatc tcatggaggc gggcgtgagc      840

gggatccagc ctcaggtcct gagtcacagg cttgagctgc cccagcttgc ctggactggc      900

ccctggggaa gtagcccaga acaaccagtg ctggggcagt gcccagcagc tgcctgaggt      960

gagggaggag gtgtgggttg atgagaatag tggcaggagg ggctgtgggc ctaagccctc     1020

aaagctggct ttctccctga agaaaaagtg gcccaaaatt gaggtgggct gcaagagctc     1080

tctaggtggc tgcggtgccc accctgcgtc ccagccctct gccctcccag gctccagagg     1140

actagcctca ggcagattac ctggttaatg accaggggca ttcacctgtg cagctgac       1198


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Forward primer for sequencing the SHC203-shRNA-1 plasmid

<400>  22
tttcttgggt agtttgcagt ttt                                               23


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Reverse primer for sequencing the SHC203-shRNA-1 plasmid

<400>  23
accgtaagtt atgtaacgcg ga                                                22


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 RealTime Forward

<400>  24
cggcaacagg acccagagtg                                                   20


<210>  25
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 RealTime Reverse

<400>  25
cggcacaagc agatggacag g                                                 21


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 qRT-PCR pair a forward

<400>  26
caggatgcct gggactacgt                                                   20


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 qRT-PCR pair a reverse

<400>  27
gacctcaggg cgattcatga                                                   20


<210>  28
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 qRT-PCR pair b forward

<400>  28
tctgtgagga agggcttctg                                                   20


<210>  29
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 qRT-PCR pair b reverse

<400>  29
gtacttgggg accttgctgt                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 qRT-PCR pair c forward

<400>  30
ggagaacctg ggcatcatcc                                                   20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 qRT-PCR pair c reverse

<400>  31
ttggggacct tgctgtagtc                                                   20


<210>  32
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 RT 2

<400>  32
tcagcgcttg gcatagag                                                     18


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 RT 3

<400>  33
gcactggttg ttctgggcta                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 RT 5

<400>  34
caacggtgtg ttgtgagagg                                                   20


<210>  35
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 Promoter 3 Forward

<400>  35
cctgatagag gccccgact                                                    19


<210>  36
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 Promoter 3 Reverse

<400>  36
attccagggc gggtgtat                                                     18


<210>  37
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 RT2 reverse complement

<400>  37
ctctatgcca agcgctga                                                     18


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 RT3 reverse complement

<400>  38
tagcccagaa caaccagtgc                                                   20


<210>  39
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KAI1 60 mer nc

<400>  39
ctctgagcct taaactgcgc attagtaaaa taggcgcaac gagagtaccc atgagttgtg       60


<210>  40
<211>  267
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  AA seq.  of KAI1 (267 aa) GenBank: AAC51205.1

<400>  40

Met Gly Ser Ala Cys Ile Lys Val Thr Lys Tyr Phe Leu Phe Leu Phe 
1               5                   10                  15      


Asn Leu Ile Phe Phe Ile Leu Gly Ala Val Ile Leu Gly Phe Gly Val 
            20                  25                  30          


Trp Ile Leu Ala Asp Lys Ser Ser Phe Ile Ser Val Leu Gln Thr Ser 
        35                  40                  45              


Ser Ser Ser Leu Arg Met Gly Ala Tyr Val Phe Ile Gly Val Gly Ala 
    50                  55                  60                  


Val Thr Met Leu Met Gly Phe Leu Gly Cys Ile Gly Ala Val Asn Glu 
65                  70                  75                  80  


Val Arg Cys Leu Leu Gly Leu Tyr Phe Ala Phe Leu Leu Leu Ile Leu 
                85                  90                  95      


Ile Ala Gln Val Thr Ala Gly Ala Leu Phe Tyr Phe Asn Met Gly Lys 
            100                 105                 110         


Leu Lys Gln Glu Met Gly Gly Ile Val Thr Glu Leu Ile Arg Asp Tyr 
        115                 120                 125             


Asn Ser Ser Arg Glu Asp Ser Leu Gln Asp Ala Trp Asp Tyr Val Gln 
    130                 135                 140                 


Ala Gln Val Lys Cys Cys Gly Trp Val Ser Phe Tyr Asn Trp Thr Asp 
145                 150                 155                 160 


Asn Ala Glu Leu Met Asn Arg Pro Glu Val Thr Tyr Pro Cys Ser Cys 
                165                 170                 175     


Glu Val Lys Gly Glu Glu Asp Asn Ser Leu Ser Val Arg Lys Gly Phe 
            180                 185                 190         


Cys Glu Ala Pro Gly Asn Arg Thr Gln Ser Gly Asn His Pro Glu Asp 
        195                 200                 205             


Trp Pro Val Tyr Gln Glu Gly Cys Met Glu Lys Val Gln Ala Trp Leu 
    210                 215                 220                 


Gln Glu Asn Leu Gly Ile Ile Leu Gly Val Gly Val Gly Val Ala Ile 
225                 230                 235                 240 


Ile Glu Leu Leu Gly Met Val Leu Ser Ile Cys Leu Cys Arg His Val 
                245                 250                 255     


His Ser Glu Asp Tyr Ser Lys Val Pro Lys Tyr 
            260                 265         


<210>  41
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPRT-1 qRT-PCR  Forward

<400>  41
gccctggcgt cgtgatta                                                     18


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPRT-1 qRT-PCR Reverse

<400>  42
ccctttccaa atcctcagca t                                                 21


<210>  43
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBP Forward

<400>  43
cacaggagcc aagagtgaag aa                                                22


<210>  44
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TBP Reverse

<400>  44
aagaacttag ctggaaaacc caac                                              24


<210>  45
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GFPtpz qRT-PCR forward

<400>  45
gttcagcgtg tccgcgagg                                                    19


<210>  46
<211>  792
<212>  RNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Sequence of the 792 bp lncRNA Suppressor of KAI1 in breast cancer
       (SKA1BC)

<400>  46
caccagccug ggcucagcgc cuuccuaauc cugcccugcc cugccccucu caucucgggc       60

ggguagcccu ggggccccca cgcuggcauu ccagggcggg uguauccggg ugccgccggg      120

gaacggcgug ggagcgguuu guguccuaag ucggggccuc uaucaggagg cggccugggc      180

ccaggaacuu uuugaaaaua cugacuacca uugauugaau ccuugccagg ggccaggcuc      240

uaugccaagc gcugaauaca guucuagccc uugaauuccc acaacucaug gguacucucg      300

uugcgccuau uuuacuaaug cgcaguuuaa ggcucagaga agggaagucg agggcucuga      360

aucucaugga ggcgggcgug agcgggaucc agccucaggu ccugagucac aggcuugagc      420

ugccccagcu ugccuggacu ggccccuggg gaaguagccc agaacaacca gugcuggggc      480

agugcccagc agcugccuga ggugagggag gagguguggg uugaugagaa uaguggcagg      540

aggggcugug ggccuaagcc cucaaagcug gcuuucuccc ugaagaaaaa guggcccaaa      600

auugaggugg gcugcaagag cucucuaggu ggcugcggug cccacccugc gucccagccc      660

ucugcccucc caggcuccag aggacuagcc ucaggcagau uaccugguua augaccaggg      720

gcauucaccu gugcagcuga caaagcucuu ucacuuccau uaucacaaug uccucucaca      780

acacaccguu gu                                                          792


<210>  47
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Broad-1 shRNA

<400>  47
ctctatgcca agcgctgaat a                                                 21


<210>  48
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Broad-2 shRNA

<400>  48
tttactaatg cgcagtttaa g                                                 21


<210>  49
<211>  78
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA Sequence encoding a segment mutual to all four transcripts, 
       known as the KAI1 enhancer with its transcription proteins 
       binding sites

<400>  49
tgttctgggc tacttcccca ggggccagtc caggcaagct ggggcagctc aagcctgtga       60

ctcaggacct gaggctgg                                                     78


<210>  50
<211>  1607
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human metastasis suppressor (KAI1) mRNA, complete cds

       GenBank: U20770.1

<400>  50
ccgactgagg cacgagcggg tgacgctggg cctgcagcgc ggagcagaaa gcagaacccg       60

cagagtcctc cctgctgctg tgtggacgac acgtgggcac aggcagaagt gggccctgtg      120

accagctgca ctggtttcgt ggaaggaagc tccaggactg gcgggatggg ctcagcctgt      180

atcaaagtca ccaaatactt tctcttcctc ttcaacttga tcttctttat cctgggcgca      240

gtgatcctgg gcttcggggt gtggatcctg gccgacaaga gcagtttcat ctctgtcctg      300

caaacctcct ccagctcgct taggatgggg gcctatgtct tcatcggcgt gggggcagtc      360

actatgctca tgggcttcct gggctgcatc ggcgccgtca acgaggtccg ctgcctgctg      420

gggctgtact ttgctttcct gctcctgatc ctcattgccc aggtgacggc cggggccctc      480

ttctacttca acatgggcaa gctgaagcag gagatgggcg gcatcgtgac tgagctcatt      540

cgagactaca acagcagtcg cgaggacagc ctgcaggatg cctgggacta cgtgcaggct      600

caggtgaagt gctgcggctg ggtcagcttc tacaactgga cagacaacgc tgagctcatg      660

aatcgccctg aggtcaccta cccctgttcc tgcgaagtca agggggaaga ggacaacagc      720

ctttctgtga ggaagggctt ctgcgaggcc cccggcaaca ggacccagag tggcaaccac      780

cctgaggact ggcctgtgta ccaggagggc tgcatggaga aggtgcaggc gtggctgcag      840

gagaacctgg gcatcatcct cggcgtgggc gtgggtgtgg ccatcatcga gctcctgggg      900

atggtcctgt ccatctgctt gtgccggcac gtccattccg aagactacag caaggtcccc      960

aagtactgag gcagctgcta tccccatctc cctgcctggc ccccaacctc agggctccca     1020

ggggtctccc tggctccctc ctccaggcct gcctcccact tcactgcgaa gaccctcttg     1080

cccaccctga ctgaaagtag ggggctttct ggggcctagc gatctctcct ggcctatccg     1140

ctgccagcct tgagccctgg ctgttctgtg gttcctctgc tcaccgccca tcagggttct     1200

cttatcaact cagagaaaaa tgctccccac agcgtccctg gcgcaggtgg gctggacttc     1260

tacctgccct caagggtgtg tatattgtat aggggcaact gtatgaaaaa ttggggagga     1320

gggggccggg cgcggtgctc acgcctgtaa tcccagcact ttgggaggcc gaggcgggtg     1380

gatcacgagg tcaggagatc gagaccatcc tggctaacat ggtgaaaccc cgtctctact     1440

aaaaatacaa aaaaaattta gccgggcgcg gtggcgggca cctgtagtcc cagctacttg     1500

ggaggctgag gcaggagaat ggtgtgaacc cgggagcgga ggttgcagtg agctgagatc     1560

gtgctactgc actccagcct gggggacaga aagagactcc gtctcaa                   1607


