                         SEQUENCE LISTING

<110>  Board of Regents of the University of Texas System
       Universitaet Zu Koeln
 
<120>  COMPOSITIONS AND METHODS FOR USE OF ANION CHANNEL RHODOPSINS

<130>  UTFH.P0330WO

<160>  118   

<170>  PatentIn version 3.5

<210>  1
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic rhodopsin (7 TM) domain (GcACR_145)

<400>  1

Met Leu Asp Ala Gln Asp Thr Gly Ser Gln Ala Val Gly Phe Gln Pro 
1               5                   10                  15      


Glu Glu Arg Met Val Val Arg Gly Lys Ala Ala Tyr Ile Asp Gly Ile 
            20                  25                  30          


Gly Pro Ala Thr Pro Tyr Ala Gly Met Tyr Gly Glu Trp Glu Ile Ala 
        35                  40                  45              


Asn Pro Asp Cys Val Asn Lys Gly Leu His Ala Thr Ser Arg Glu Arg 
    50                  55                  60                  


Thr Ile Ile Thr Leu Trp Ala Val Val Cys Leu Cys Gln Ala Leu Phe 
65                  70                  75                  80  


Met Met Thr Arg Ala Pro Lys Val Thr Trp Glu Ala Val Tyr Leu Pro 
                85                  90                  95      


Leu Val Glu Cys Ile Leu Tyr Cys Cys Thr Gly Ala Gly Tyr Gly Val 
            100                 105                 110         


Leu Arg Met Gly Asp Gly Arg Met Leu Pro Leu Ser Arg Met Cys Ser 
        115                 120                 125             


Trp Leu Ile Thr Cys Pro Ile Met Leu Ser Gln Ala Phe Gly Ile His 
    130                 135                 140                 


Asp Met Lys Leu Tyr Gly Ile Gln Leu Arg Met Pro Ile Cys Ala Ala 
145                 150                 155                 160 


Ser Leu Ile Arg Thr Val Cys Gly Leu Leu Ala Ser Thr Thr Thr Asp 
                165                 170                 175     


Thr Lys Ile Ala Lys Trp Leu Phe Phe Phe Leu Gly Phe Ser Phe Tyr 
            180                 185                 190         


Thr Met Glu Ile Thr Thr Val Trp Phe Ile Phe Gln Gln Gly Ile Ala 
        195                 200                 205             


Lys Phe Thr Pro Thr Thr Asp Val Pro Glu Asn Ala Thr Ala Leu Arg 
    210                 215                 220                 


Arg Leu Tyr Phe Met Arg Phe Ile Phe Phe Thr Ser Trp Thr Ala Phe 
225                 230                 235                 240 


Pro Val Phe Trp Val Leu Ser Ser Thr Gly Leu Cys Val Ile Ser Glu 
                245                 250                 255     


Gln Thr Ser Ala Leu Gly Tyr Leu Cys Ala Asp Ala Leu Cys Lys Asn 
            260                 265                 270         


Leu Tyr Gly Val Ile Gln Thr Asn Thr Val Trp Gly Leu Leu Gly Gly 
        275                 280                 285             


Thr Trp Thr Pro Lys Lys His Pro Asn Asn His Asp Glu Glu Ala Pro 
    290                 295                 300                 


Ala Asn Ser His Asn His Lys Glu Glu Asp Thr Phe Ala Ala Pro His 
305                 310                 315                 320 


Gly Arg Phe Asn Ser Ala 
                325     


<210>  2
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized rhodopsin (7 TM) domain (GcACR_145-1)

<400>  2
atgctcgacg ctcaggacac cggcagccaa gccgtgggat tccagcctga agagagaatg       60

gtggtcaggg gaaaggccgc ctacatcgat ggcatcggcc ctgccacccc ttacgctggc      120

atgtacggcg agtgggagat cgccaacccc gattgcgtga acaagggcct gcacgccacc      180

agcagggaga gaacaatcat cacactctgg gccgtggtgt gcctctgtca ggccctgttc      240

atgatgacca gggcccccaa ggtgacctgg gaagccgtgt acctgcccct ggtggagtgc      300

atcctgtact gctgcaccgg cgccggatac ggagtcctca ggatgggcga cggcagaatg      360

ctgcccctgt ccagaatgtg tagctggctg atcacctgtc ccatcatgct gagccaggct      420

ttcggcatcc acgacatgaa gctctacggc atccagctga ggatgcccat ctgcgccgcc      480

agcctgatca ggaccgtgtg tggcctgctg gccagcacca ccaccgacac caagatcgcc      540

aagtggctgt tcttcttcct gggcttcagc ttctacacca tggagatcac cacagtgtgg      600

ttcatcttcc agcagggcat cgccaagttc acccccacca ccgacgtccc tgaaaacgcc      660

acagccctga ggaggctgta cttcatgagg ttcatcttct tcacctcctg gaccgctttc      720

cctgtgtttt gggtgctgag ctccaccggc ctctgtgtga tctccgaaca gacatccgcc      780

ctgggctacc tgtgcgccga cgccctgtgc aagaacctgt atggcgtcat ccagaccaac      840

accgtgtggg gcctcctggg cggaacatgg acccccaaga agcaccccaa caaccacgac      900

gaagaggccc ccgccaatag ccacaaccac aaggaggagg acaccttcgc cgcccctcat      960

ggcagattca acagcgcc                                                    978


<210>  3
<211>  329
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic rhodopsin (7 TM) domain (C1ACR_887)

<400>  3

Met Glu His His Ser Tyr Asp Gly Ala Met Arg Ser Leu Gln Ala Ile 
1               5                   10                  15      


Ser Gly Ser Phe Ala Asp Ile Glu Gly His Trp Asn Gly Pro Thr Ser 
            20                  25                  30          


Val Leu Asp Asn Pro Ala Val Ile Asp Gly Gln Leu Tyr Gly Ala Tyr 
        35                  40                  45              


Val Phe Met His Pro Glu Cys His Gln Gly Glu Tyr Ala Pro Ile Val 
    50                  55                  60                  


Lys Ile Ile Gln Leu Cys Trp Ala Val Ile Cys Met Cys Gln Val Leu 
65                  70                  75                  80  


Phe Met Phe Ser Arg Ala Pro Arg Val Pro Trp Glu Ala Met Tyr Leu 
                85                  90                  95      


Pro Gly Val Glu Cys Val Ile Tyr Thr Leu Ala Phe Thr Gly Asn Gly 
            100                 105                 110         


Tyr Val Arg Met Val Asp Gly Arg Ile Leu Thr Trp Ser Arg Leu Ala 
        115                 120                 125             


Ser Trp Leu Val Cys Cys Pro Val Met Leu Gly Gln Ile Ser Ala Ile 
    130                 135                 140                 


Thr Leu Ile Lys Tyr Gln Ser Ile Pro Leu Asn Pro Met Met Ile Ala 
145                 150                 155                 160 


Cys Ser Ile Ile Arg Thr Val Phe Gly Val Ser Ala Gly Val Val Gln 
                165                 170                 175     


Glu Glu Pro Leu Lys Trp Val Phe Phe Trp Leu Gly Ile Phe Phe Phe 
            180                 185                 190         


Ala Phe Glu Leu Leu Gly Cys Tyr Leu Ile Phe Ala Ile Ala Ile Ala 
        195                 200                 205             


Asp Phe Glu Ala Cys Lys Thr Glu Leu Ala Asn Lys Val Ile Gly Arg 
    210                 215                 220                 


Ile Lys Thr Met Arg Ala Ile Ile Phe Ile Cys Trp Pro Ala Ile Thr 
225                 230                 235                 240 


Val Thr Trp Val Leu Ser Ser Ala Gly Thr Cys Leu Val Asp Asp Asn 
                245                 250                 255     


Tyr Thr Thr Ile Gly Phe Val Val Leu Asp Ala Val Cys Lys Asn Met 
            260                 265                 270         


Tyr Gly Val Val Ile Trp Ser Thr Thr Trp Gly Leu Leu Asn Gly Lys 
        275                 280                 285             


Trp Asp Arg Asp Tyr Ala Arg Thr Phe Gly Gln Glu Glu Glu Gln Gln 
    290                 295                 300                 


Glu Glu Ala Pro Asp Phe Asp Ala Lys Gly Gly Ala Met Pro Gly Ala 
305                 310                 315                 320 


Asn Asp Asn Val Glu Val Lys Met Phe 
                325                 


<210>  4
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized rhodopsin (7 TM) domain (C1ACR_887-1)

<400>  4
atggagcatc acagctacga tggcgccatg aggagcctgc aggctatcag cggctccttc       60

gccgacatcg agggacactg gaacggcccc acctccgtgc tggataaccc cgccgtgatc      120

gacggacagc tgtacggagc ctatgtcttc atgcaccctg agtgccacca gggcgagtac      180

gcccccattg tgaagatcat ccagctgtgc tgggccgtga tctgcatgtg ccaagtgctg      240

ttcatgttca gcagggcccc tagggtgccc tgggaggcca tgtatctgcc cggcgtggag      300

tgcgtgatct acaccctggc cttcacaggc aacggctacg tgaggatggt ggacggcaga      360

atcctgacct ggagcagact ggccagctgg ctggtgtgtt gccctgtgat gctgggccag      420

atctccgcca tcaccctgat caagtaccag tccatccctc tgaaccccat gatgatcgcc      480

tgcagcatca ttaggaccgt gtttggcgtg agcgctggcg tggtgcaaga ggagcccctg      540

aagtgggtgt tcttctggct gggcatcttc tttttcgcct tcgagctgct gggctgctac      600

ctgattttcg ctatcgccat cgccgacttc gaggcctgca agaccgaact ggccaacaaa      660

gtgatcggca gaatcaagac catgagggcc atcatcttca tctgctggcc cgccatcacc      720

gtgacatggg tgctgtcctc cgccggcacc tgtctggtgg acgacaacta caccaccatc      780

ggcttcgtcg tgctggacgc tgtgtgcaag aacatgtacg gcgtcgtcat ctggagcacc      840

acctggggcc tcctgaacgg caagtgggac agagactacg ccagaacctt cggccaggag      900

gaagaacagc aggaggaagc ccctgacttt gacgccaagg gaggagccat gcctggcgcc      960

aacgacaatg tggaggtgaa gatgttc                                          987


<210>  5
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic rhodopsin (7 TM) domain (C1ACR_23)

<400>  5

Met Thr Val Leu Glu Val Asn Glu Ala Val Ile Ile Asp Gly Val Met 
1               5                   10                  15      


Tyr Gly Glu Tyr Ile Phe Ser His Pro Gln Cys Ile Pro Ala Glu Leu 
            20                  25                  30          


Val Pro Val Val Lys Val Phe Gln Ile Cys Trp Ala Val Val Ser Met 
        35                  40                  45              


Cys Gln Ser Ala Phe Met Met Thr Arg Met Pro Lys Val Pro Trp Glu 
    50                  55                  60                  


Ala Ile Tyr Leu Pro Met Val Glu Ala Ile Val Tyr Val Met Ala Tyr 
65                  70                  75                  80  


Thr Gly Asn Gly Tyr Leu Lys Met Gly Ser Gly Arg Val Leu Pro Trp 
                85                  90                  95      


Ala Arg Met Ala Ser Trp Leu Val Thr Cys Pro Val Met His Gly Gln 
            100                 105                 110         


Ile Ser Gly Met Thr Leu Ile Lys Tyr Gln Ser Ile Pro Ile Asn Pro 
        115                 120                 125             


Met Val Ile Ala Ala Ser Ile Ile Arg Val Val Met Gly Val Thr Ala 
    130                 135                 140                 


Thr Ile Val Val Thr Glu Asp Leu Lys Trp Ala Phe Phe Gly Cys Gly 
145                 150                 155                 160 


Leu Val Cys Leu Leu Phe Glu Tyr Ala Ser Val Tyr Thr Ile Phe Ala 
                165                 170                 175     


Val Thr Ile Gly Asp Phe Ala Asp Ala Lys Thr Asp Leu Gly Asn Gln 
            180                 185                 190         


Val Val Ala Arg Leu Lys Ser Ile Arg Ser Ile Phe Phe Val Ala Trp 
        195                 200                 205             


Thr Ala Phe Pro Ile Leu Trp Leu Leu Ser Ser Thr Gly Thr Cys Val 
    210                 215                 220                 


Ile Asp Glu Asn Ile Ser Ala Val Ala Tyr Leu Ile Ser Asp Ala Phe 
225                 230                 235                 240 


Cys Lys Asn Phe Asn Gly Ile Leu Leu Trp Ser Thr Thr Trp Gly Leu 
                245                 250                 255     


Leu Asn Gly Lys Trp Asp Arg Asp Phe Val Arg Ala Pro Pro Ala Ala 
            260                 265                 270         


Glu Ser Glu Lys Asp Val Gln Asp Ala Pro Arg Pro Lys Ser Asp Val 
        275                 280                 285             


Glu Val Lys Met Phe Gly Lys Val Ile Gly Ser Val 
    290                 295                 300 


<210>  6
<211>  903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized rhodopsin (7 TM) domain (C1ACR_23-1)

<400>  6
atgaccgtgc tggaagtgaa cgaagccgtg atcatcgacg gagtgatgta cggcgaatac       60

atcttctccc atccccagtg tatccctgcc gagctcgtgc ccgtggtgaa ggtgtttcag      120

atctgctggg ccgtggtgag catgtgccag tccgccttca tgatgaccag aatgcccaag      180

gtgccctggg aagccatcta cctgcccatg gtggaggcca tcgtctacgt catggcctac      240

acaggaaacg gctacctgaa gatgggctcc ggcagagtgc tgccttgggc caggatggcc      300

agctggctgg tgacctgccc cgtgatgcac ggacagatct ccggcatgac cctgatcaag      360

taccagagca tccctatcaa ccccatggtc atcgccgcca gcatcatcag agtggtgatg      420

ggcgtgaccg ctaccatcgt ggtgaccgaa gacctcaagt gggccttctt cggctgcgga      480

ctggtctgcc tgctgttcga gtacgccagc gtgtacacca tcttcgccgt gaccattggc      540

gactttgccg acgccaagac cgatctgggc aaccaggtgg tggccaggct gaagagcatc      600

aggagcatct tcttcgtcgc ctggaccgcc ttccccattc tgtggctcct gagcagcacc      660

ggcacatgcg tgatcgacga gaacatcagc gccgtggcct acctgattag cgacgccttc      720

tgcaagaact tcaacggaat cctgctgtgg tccaccacct ggggcctgct gaacggcaag      780

tgggataggg acttcgtgag ggcccctcct gctgccgaat ccgagaagga cgtgcaggac      840

gcccccagac ccaagagcga cgtggaggtg aagatgttcg gcaaggtgat cggcagcgtg      900

agg                                                                    903


<210>  7
<211>  303
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic rhodopsin (7 TM) domain (R1ACR_799)

<400>  7

Met Ala Gly Val Gln Asp Asp Trp Ser Ala Val Ser Val Pro Ala Phe 
1               5                   10                  15      


Gly Gln Tyr Gly Thr Trp Glu Ala Ala Asn Pro Glu Cys Val Glu Met 
            20                  25                  30          


Gly Leu Ser Thr Ser Lys Asn Thr Lys Met Ile Gln Leu Leu Phe Ala 
        35                  40                  45              


Ser Ile Cys Ala Cys Gln Val Leu Phe Met Ala Ser Arg Ala Pro Arg 
    50                  55                  60                  


Val Thr Trp Glu Ala Val Tyr Leu Pro Leu Val Glu Thr Ile Leu Tyr 
65                  70                  75                  80  


Gly Met Ala Ser Thr Gly Asn Gly Ser Met Arg Leu Ala Asp Gly Arg 
                85                  90                  95      


Met Val Pro Ile Ala Arg Phe Cys Ser Trp Ile Ile Thr Cys Pro Ile 
            100                 105                 110         


Met Leu Phe Gln Val Val Gly Ile His Glu Val Lys Val Tyr Gly Ile 
        115                 120                 125             


Ser Cys Lys Asn Met Val Met Ala Ala Ser Leu Val Arg Thr Val Tyr 
    130                 135                 140                 


Gly Ile Gly Ala Ser Val Thr Ile Asp Asp Lys Met Arg Trp Ile Gln 
145                 150                 155                 160 


Tyr Met Leu Ser Cys Phe Thr Phe Leu Phe Glu Leu Trp Cys Val Tyr 
                165                 170                 175     


Gln Ile Tyr Asn Ala Gly Leu Lys Lys Phe Ser Ala Val Lys Thr Pro 
            180                 185                 190         


Leu Asn Asn Ile Val His Ser Arg Ile Gln Phe Leu Arg Phe Leu Phe 
        195                 200                 205             


Tyr Leu Ser Trp Ser Ser Phe Pro Ile Val Trp Val Leu Ser Ser Thr 
    210                 215                 220                 


Gly Leu Cys Leu Ile Asn Glu Asp Gly Ser Val Leu Ala Tyr Leu Val 
225                 230                 235                 240 


Ala Asp Ile Leu Cys Lys Asn Thr Tyr Gly Ile Ile Asn Ala Asn Thr 
                245                 250                 255     


Leu Phe Arg Val Leu Asp Gly Lys Trp Thr Pro Glu Thr Leu Glu Glu 
            260                 265                 270         


Ala Ala Asn Thr Tyr Gly Ile Ile Asn Ala Asn Thr Leu Phe Arg Val 
        275                 280                 285             


Leu Asn Gly Lys Trp Glu Pro Glu Thr Glu Glu Glu Ala Lys Asn 
    290                 295                 300             


<210>  8
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized rhodopsin (7 TM) domain (R1ACR_799-1)

<400>  8
atggccggcg tgcaggatga ctggagcgct gtgagcgtgc ctgccttcgg ccagtatggc       60

acatgggaag ctgccaaccc tgagtgcgtc gagatgggcc tgagcaccag caagaacacc      120

aagatgatcc agctgctgtt cgccagcatt tgtgcctgtc aggtgctgtt catggcctcc      180

agagccccca gagtgacctg ggaggccgtg tacctgcccc tggtggaaac catcctgtat      240

ggcatggcct ccaccggcaa cggctccatg aggctggctg acggcagaat ggtgcccatc      300

gccaggttct gcagctggat catcacctgc cccatcatgc tctttcaggt ggtgggcatt      360

cacgaggtga aagtgtacgg catttcctgc aaaaacatgg tgatggccgc cagcctggtg      420

aggaccgtgt acggcatcgg agcctccgtc accatcgacg acaaaatgag gtggattcaa      480

tacatgctgt cctgcttcac cttcctgttc gagctgtggt gcgtgtacca gatctacaac      540

gccggcctga agaagttcag cgccgtcaag acccccctga ataacatcgt gcactcccgt      600

attcaattcc tgaggttcct cttctacctg agctggagca gcttccccat cgtgtgggtg      660

ctgagcagca ccggactgtg cctgatcaac gaggacggct ccgtgctggc ttacctggtc      720

gccgatatcc tgtgcaagaa cacctacgga atcatcaacg ctaataccct gttcagggtg      780

ctggatggca aatggacacc cgagaccctg gaggaggccg ccaacaccta cggcattatc      840

aacgccaaca ccctgtttag agtgctgaac ggaaagtggg agcccgagac cgaggaggaa      900

gctaaaaac                                                              909


<210>  9
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic rhodopsin (7 TM) domain (R1ACR_367)

<400>  9

Met Ser Tyr Val Glu Asp Pro Ala Phe Gly Phe Tyr Gly Ser Trp Glu 
1               5                   10                  15      


Ala Ala Asn Gln Asp Cys Ile Glu Arg Gly Leu Ser Thr Thr Asn Asn 
            20                  25                  30          


Thr Arg Met Ile Gln Leu Leu Phe Ala Ser Ile Cys Ala Cys Gln Val 
        35                  40                  45              


Leu Phe Met Ala Ser Arg Ala Pro Arg Val Thr Trp Glu Ala Val Tyr 
    50                  55                  60                  


Leu Pro Val Val Glu Thr Val Leu Tyr Gly Met Ala Ser Thr Gly Asn 
65                  70                  75                  80  


Gly Ser Met Arg Leu Ala Asp Gly Arg Ile Val Pro Ile Ala Arg Phe 
                85                  90                  95      


Cys Ser Trp Leu Ile Thr Cys Pro Ile Met Leu Phe Gln Val Val Gly 
            100                 105                 110         


Ile His Glu Leu Lys Trp Arg Thr Ile Ser Cys Lys Asn Met Val Met 
        115                 120                 125             


Ala Ala Ser Leu Ile Arg Thr Val Phe Gly Ile Gly Ala Ser Val Thr 
    130                 135                 140                 


Ile Thr Pro Thr Met Arg Trp Val Gln Tyr Phe Leu Ser Leu Ser Phe 
145                 150                 155                 160 


Phe Leu Phe Glu Leu Ile Val Val Tyr Gln Ile Phe Ser Ala Gly Leu 
                165                 170                 175     


Lys Lys Phe Gly Ala Val Lys Thr Ser Leu Asn Asn Ile Val Tyr Ser 
            180                 185                 190         


Arg Ile Met Phe Leu Arg Phe Leu Phe Phe Leu Ser Trp Ser Ser Phe 
        195                 200                 205             


Pro Ile Ile Trp Leu Leu Ser Ser Thr Gly Phe Cys Leu Val Asn Glu 
    210                 215                 220                 


Asp Val Ser Val Leu Ala Tyr Leu Val Ala Asp Met Ile Cys Lys Asn 
225                 230                 235                 240 


Leu Tyr Gly Ile Thr Asn Ala Asn Thr Leu Phe Arg Val Leu Asn Gly 
                245                 250                 255     


Lys Trp Thr Pro Glu Thr Glu Glu Glu Ala Lys Gln Pro Lys Asp Asn 
            260                 265                 270         


Glu His Ala His Val Gly Glu Thr Tyr Phe Glu Gln Met Leu Ser Gly 
        275                 280                 285             


Leu Arg Gly Ser Arg His 
    290                 


<210>  10
<211>  882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R1ACR_367-1

<400>  10
atgagctacg tggaggaccc tgccttcggc ttctacggct cctgggaggc cgccaaccag       60

gactgtattg aaaggggcct cagcaccacc aacaatacca ggatgatcca gctgctgttc      120

gcctccatct gcgcctgcca ggtcctgttt atggccagca gggcccctag ggtgacatgg      180

gaggccgtgt acctgcccgt ggtggagacc gtgctgtacg gcatggccag caccggcaac      240

ggcagcatga gactggccga cggcaggatc gtgcctatcg ccaggttctg tagctggctg      300

atcacctgcc ccattatgct gttccaggtc gtgggcatcc acgagctgaa gtggaggacc      360

atcagctgca agaacatggt gatggccgcc agcctgatca gaaccgtgtt tggcatcggc      420

gcctccgtga caattacccc caccatgaga tgggtgcagt acttcctgtc cctgtccttc      480

ttcctgttcg agctgatcgt ggtctaccag atcttcagcg ccggcctgaa gaaattcggc      540

gccgtgaaga caagcctgaa caacatcgtc tacagcagga tcatgttcct gaggttcctg      600

ttcttcctga gctggtccag cttccccatc atctggctgc tgtccagcac cggcttttgt      660

ctggtgaacg aggacgtgag cgtgctggcc tacctggtcg ctgacatgat ctgcaagaac      720

ctgtacggca tcaccaatgc caacaccctg ttcagggtgc tcaacggcaa gtggacccct      780

gagacagagg aggaggccaa gcagcctaag gacaacgagc acgcccatgt gggcgagacc      840

tatttcgagc agatgctgag cggcctgaga ggaagcaggc ac                         882


<210>  11
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct GcACR_145-2

<400>  11
atgctggacg cccaggacac cggcagccag gccgtgggct tccagcccga ggagcgcatg       60

gtggtgcgcg gcaaggccgc ctacatcgac ggcatcggcc ccgccacccc ctacgccggc      120

atgtacggcg agtgggagat cgccaacccc gactgcgtga acaagggcct gcacgccacc      180

agccgcgagc gcaccatcat caccctgtgg gccgtggtgt gcctgtgcca ggccctgttc      240

atgatgaccc gcgcccccaa ggtgacctgg gaggccgtgt acctgcccct ggtggagtgc      300

atcctgtact gctgcaccgg cgccggctac ggcgtgctgc gcatgggcga cggccgcatg      360

ctgcccctga gccgcatgtg cagctggctg atcacctgcc ccatcatgct gagccaggcc      420

ttcggcatcc acgacatgaa gctgtacggc atccagctgc gcatgcccat ctgcgccgcc      480

agcctgatcc gcaccgtgtg cggcctgctg gccagcacca ccaccgacac caagatcgcc      540

aagtggctgt tcttcttcct gggcttcagc ttctacacca tggagatcac caccgtgtgg      600

ttcatcttcc agcagggcat cgccaagttc acccccacca ccgacgtgcc cgagaacgcc      660

accgccctgc gccgcctgta cttcatgcgc ttcatcttct tcaccagctg gaccgccttc      720

cccgtgttct gggtgctgag cagcaccggc ctgtgcgtga tcagcgagca gaccagcgcc      780

ctgggctacc tgtgcgccga cgccctgtgc aagaacctgt acggcgtgat ccagaccaac      840

accgtgtggg gcctgctggg cggcacctgg acccccaaga agcaccccaa caaccacgac      900

gaggaggccc ccgccaacag ccacaaccac aaggaggagg acaccttcgc cgccccccac      960

ggccgcttca acagcgcc                                                    978


<210>  12
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct C1ACR_887-2

<400>  12
atggagcacc acagctacga cggcgccatg cgcagcctgc aggccatcag cggcagcttc       60

gccgacatcg agggccactg gaacggcccc accagcgtgc tggacaaccc cgccgtgatc      120

gacggccagc tgtacggcgc ctacgtgttc atgcaccccg agtgccacca gggcgagtac      180

gcccccatcg tgaagatcat ccagctgtgc tgggccgtga tctgcatgtg ccaggtgctg      240

ttcatgttca gccgcgcccc ccgcgtgccc tgggaggcca tgtacctgcc cggcgtggag      300

tgcgtgatct acaccctggc cttcaccggc aacggctacg tgcgcatggt ggacggccgc      360

atcctgacct ggagccgcct ggccagctgg ctggtgtgct gccccgtgat gctgggccag      420

atcagcgcca tcaccctgat caagtaccag agcatccccc tgaaccccat gatgatcgcc      480

tgcagcatca tccgcaccgt gttcggcgtg agcgccggcg tggtgcagga ggagcccctg      540

aagtgggtgt tcttctggct gggcatcttc ttcttcgcct tcgagctgct gggctgctac      600

ctgatcttcg ccatcgccat cgccgacttc gaggcctgca agaccgagct ggccaacaag      660

gtgatcggcc gcatcaagac catgcgcgcc atcatcttca tctgctggcc cgccatcacc      720

gtgacctggg tgctgagcag cgccggcacc tgcctggtgg acgacaacta caccaccatc      780

ggcttcgtgg tgctggacgc cgtgtgcaag aacatgtacg gcgtggtgat ctggagcacc      840

acctggggcc tgctgaacgg caagtgggac cgcgactacg cccgcacctt cggccaggag      900

gaggagcagc aggaggaggc ccccgacttc gacgccaagg gcggcgccat gcccggcgcc      960

aacgacaacg tggaggtgaa gatgttc                                          987


<210>  13
<211>  903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct C1ACR_023-2

<400>  13
atgaccgtgc tggaggtgaa cgaggccgtg atcatcgacg gcgtgatgta cggcgagtac       60

atcttcagcc acccccagtg catccccgcc gagctggtgc ccgtggtgaa ggtgttccag      120

atctgctggg ccgtggtgag catgtgccag agcgccttca tgatgacccg catgcccaag      180

gtgccctggg aggccatcta cctgcccatg gtggaggcca tcgtgtacgt gatggcctac      240

accggcaacg gctacctgaa gatgggcagc ggccgcgtgc tgccctgggc ccgcatggcc      300

agctggctgg tgacctgccc cgtgatgcac ggccagatca gcggcatgac cctgatcaag      360

taccagagca tccccatcaa ccccatggtg atcgccgcca gcatcatccg cgtggtgatg      420

ggcgtgaccg ccaccatcgt ggtgaccgag gacctgaagt gggccttctt cggctgcggc      480

ctggtgtgcc tgctgttcga gtacgccagc gtgtacacca tcttcgccgt gaccatcggc      540

gacttcgccg acgccaagac cgacctgggc aaccaggtgg tggcccgcct gaagagcatc      600

cgcagcatct tcttcgtggc ctggaccgcc ttccccatcc tgtggctgct gagcagcacc      660

ggcacctgcg tgatcgacga gaacatcagc gccgtggcct acctgatcag cgacgccttc      720

tgcaagaact tcaacggcat cctgctgtgg agcaccacct ggggcctgct gaacggcaag      780

tgggaccgcg acttcgtgcg cgcccccccc gccgccgaga gcgagaagga cgtgcaggac      840

gccccccgcc ccaagagcga cgtggaggtg aagatgttcg gcaaggtgat cggcagcgtg      900

cgc                                                                    903


<210>  14
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R1ACR_799-2

<400>  14
atggccggcg tgcaggacga ctggagcgcc gtgagcgtgc ccgccttcgg ccagtacggc       60

acctgggagg ccgccaaccc cgagtgcgtg gagatgggcc tgagcaccag caagaacacc      120

aagatgatcc agctgctgtt cgccagcatc tgcgcctgcc aggtgctgtt catggccagc      180

cgcgcccccc gcgtgacctg ggaggccgtg tacctgcccc tggtggagac catcctgtac      240

ggcatggcca gcaccggcaa cggcagcatg cgcctggccg acggccgcat ggtgcccatc      300

gcccgcttct gcagctggat catcacctgc cccatcatgc tgttccaggt ggtgggcatc      360

cacgaggtga aggtgtacgg catcagctgc aagaacatgg tgatggccgc cagcctggtg      420

cgcaccgtgt acggcatcgg cgccagcgtg accatcgacg acaagatgcg ctggatccag      480

tacatgctga gctgcttcac cttcctgttc gagctgtggt gcgtgtacca gatctacaac      540

gccggcctga agaagttcag cgccgtgaag acccccctga acaacatcgt gcacagccgc      600

atccagttcc tgcgcttcct gttctacctg agctggagca gcttccccat cgtgtgggtg      660

ctgagcagca ccggcctgtg cctgatcaac gaggacggca gcgtgctggc ctacctggtg      720

gccgacatcc tgtgcaagaa cacctacggc atcatcaacg ccaacaccct gttccgcgtg      780

ctggacggca agtggacccc cgagaccctg gaggaggccg ccaacaccta cggcatcatc      840

aacgccaaca ccctgttccg cgtgctgaac ggcaagtggg agcccgagac cgaggaggag      900

gccaagaac                                                              909


<210>  15
<211>  882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R1ACR_367-2

<400>  15
atgagctacg tggaggaccc cgccttcggc ttctacggca gctgggaggc cgccaaccag       60

gactgcatcg agcgcggcct gagcaccacc aacaacaccc gcatgatcca gctgctgttc      120

gccagcatct gcgcctgcca ggtgctgttc atggccagcc gcgccccccg cgtgacctgg      180

gaggccgtgt acctgcccgt ggtggagacc gtgctgtacg gcatggccag caccggcaac      240

ggcagcatgc gcctggccga cggccgcatc gtgcccatcg cccgcttctg cagctggctg      300

atcacctgcc ccatcatgct gttccaggtg gtgggcatcc acgagctgaa gtggcgcacc      360

atcagctgca agaacatggt gatggccgcc agcctgatcc gcaccgtgtt cggcatcggc      420

gccagcgtga ccatcacccc caccatgcgc tgggtgcagt acttcctgag cctgagcttc      480

ttcctgttcg agctgatcgt ggtgtaccag atcttcagcg ccggcctgaa gaagttcggc      540

gccgtgaaga ccagcctgaa caacatcgtg tacagccgca tcatgttcct gcgcttcctg      600

ttcttcctga gctggagcag cttccccatc atctggctgc tgagcagcac cggcttctgc      660

ctggtgaacg aggacgtgag cgtgctggcc tacctggtgg ccgacatgat ctgcaagaac      720

ctgtacggca tcaccaacgc caacaccctg ttccgcgtgc tgaacggcaa gtggaccccc      780

gagaccgagg aggaggccaa gcagcccaag gacaacgagc acgcccacgt gggcgagacc      840

tacttcgagc agatgctgag cggcctgcgc ggcagccgcc ac                         882


<210>  16
<211>  978
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct GcACR_145-2

<400>  16
atgctggacg cccaggacac cggcagccag gccgtgggct tccagcccga ggagagaatg       60

gtggtgagag gcaaggccgc ctacatcgat ggcatcggcc ccgccacccc ctacgccggc      120

atgtacggcg agtgggagat cgccaacccc gattgcgtga acaagggcct gcacgccacc      180

agcagagaga gaaccatcat caccctgtgg gccgtggtgt gcctgtgcca ggccctgttc      240

atgatgacca gagcccccaa ggtgacctgg gaggccgtgt acctgcccct ggtggagtgc      300

atcctgtact gctgcaccgg cgccggctac ggcgtgctga gaatgggcga cggcagaatg      360

ctgcccctga gcagaatgtg cagctggctg atcacctgcc ccatcatgct gagccaggcc      420

ttcggcatcc acgacatgaa gctgtacggc atccagctga gaatgcccat ctgcgccgcc      480

agcctgatca gaaccgtgtg cggcctgctg gccagcacca ccaccgacac caagatcgcc      540

aagtggctgt tcttcttcct gggcttcagc ttctacacca tggagatcac caccgtgtgg      600

ttcatcttcc agcagggcat cgccaagttc acccccacca ccgacgtgcc cgagaacgcc      660

accgccctga gaagactgta cttcatgaga ttcatcttct tcaccagctg gaccgccttc      720

cccgtgttct gggtgctgag cagcaccggc ctgtgcgtga tcagcgagca gaccagcgcc      780

ctgggctacc tgtgcgccga cgccctgtgc aagaacctgt acggcgtgat ccagaccaac      840

accgtgtggg gcctgctggg cggcacctgg acccccaaga agcaccccaa caaccacgac      900

gaggaggccc ccgccaacag ccacaaccac aaggaggagg acaccttcgc cgccccccac      960

ggcagattca acagcgcc                                                    978


<210>  17
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct C1ACR_887-3

<400>  17
atggagcacc acagctacga tggcgccatg agaagcctgc aggccatcag cggcagcttc       60

gccgacatcg agggccactg gaacggcccc accagcgtgc tggataaccc cgccgtgatc      120

gacggccagc tgtacggcgc ctacgtgttc atgcaccccg agtgccacca gggcgagtac      180

gcccccatcg tgaagatcat ccagctgtgc tgggccgtga tctgcatgtg ccaggtgctg      240

ttcatgttca gcagagcccc cagagtgccc tgggaggcca tgtacctgcc cggcgtggag      300

tgcgtgatct acaccctggc cttcaccggc aacggctacg tgagaatggt ggacggcaga      360

atcctgacct ggagcagact ggccagctgg ctggtgtgct gccccgtgat gctgggccag      420

atcagcgcca tcaccctgat caagtaccag agcatccccc tgaaccccat gatgatcgcc      480

tgcagcatca tcagaaccgt gttcggcgtg agcgccggcg tggtgcagga ggagcccctg      540

aagtgggtgt tcttctggct gggcatcttc ttcttcgcct tcgagctgct gggctgctac      600

ctgatcttcg ccatcgccat cgccgacttc gaggcctgca agaccgagct ggccaacaag      660

gtgatcggca gaatcaagac catgagagcc atcatcttca tctgctggcc cgccatcacc      720

gtgacctggg tgctgagcag cgccggcacc tgcctggtgg acgacaacta caccaccatc      780

ggcttcgtgg tgctggacgc cgtgtgcaag aacatgtacg gcgtggtgat ctggagcacc      840

acctggggcc tgctgaacgg caagtgggac agagactacg ccagaacctt cggccaggag      900

gaggagcagc aggaggaggc ccccgacttc gacgccaagg gcggcgccat gcccggcgcc      960

aacgacaacg tggaggtgaa gatgttc                                          987


<210>  18
<211>  903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct C1ACR_023-3

<400>  18
atgaccgtgc tggaggtgaa cgaggccgtg atcatcgacg gcgtgatgta cggcgagtac       60

atcttcagcc acccccagtg catccccgcc gagctggtgc ccgtggtgaa ggtgttccag      120

atctgctggg ccgtggtgag catgtgccag agcgccttca tgatgaccag aatgcccaag      180

gtgccctggg aggccatcta cctgcccatg gtggaggcca tcgtgtacgt gatggcctac      240

accggcaacg gctacctgaa gatgggcagc ggcagagtgc tgccctgggc cagaatggcc      300

agctggctgg tgacctgccc cgtgatgcac ggccagatca gcggcatgac cctgatcaag      360

taccagagca tccccatcaa ccccatggtg atcgccgcca gcatcatcag agtggtgatg      420

ggcgtgaccg ccaccatcgt ggtgaccgag gacctgaagt gggccttctt cggctgcggc      480

ctggtgtgcc tgctgttcga gtacgccagc gtgtacacca tcttcgccgt gaccatcggc      540

gacttcgccg acgccaagac cgatctgggc aaccaggtgg tggccagact gaagagcatc      600

agaagcatct tcttcgtggc ctggaccgcc ttccccatcc tgtggctgct gagcagcacc      660

ggcacctgcg tgatcgacga gaacatcagc gccgtggcct acctgatcag cgacgccttc      720

tgcaagaact tcaacggcat cctgctgtgg agcaccacct ggggcctgct gaacggcaag      780

tgggatagag acttcgtgag agcccccccc gccgccgaga gcgagaagga cgtgcaggac      840

gcccccagac ccaagagcga cgtggaggtg aagatgttcg gcaaggtgat cggcagcgtg      900

aga                                                                    903


<210>  19
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R1ACR_799-3

<400>  19
atggccggcg tgcaggatga ctggagcgcc gtgagcgtgc ccgccttcgg ccagtacggc       60

acctgggagg ccgccaaccc cgagtgcgtg gagatgggcc tgagcaccag caagaacacc      120

aagatgatcc agctgctgtt cgccagcatc tgcgcctgcc aggtgctgtt catggccagc      180

agagccccca gagtgacctg ggaggccgtg tacctgcccc tggtggagac catcctgtac      240

ggcatggcca gcaccggcaa cggcagcatg agactggccg acggcagaat ggtgcccatc      300

gccagattct gcagctggat catcacctgc cccatcatgc tgttccaggt ggtgggcatc      360

cacgaggtga aggtgtacgg catcagctgc aagaacatgg tgatggccgc cagcctggtg      420

agaaccgtgt acggcatcgg cgccagcgtg accatcgacg acaagatgag atggatccag      480

tacatgctga gctgcttcac cttcctgttc gagctgtggt gcgtgtacca gatctacaac      540

gccggcctga agaagttcag cgccgtgaag acccccctga acaacatcgt gcacagcaga      600

atccagttcc tgagattcct gttctacctg agctggagca gcttccccat cgtgtgggtg      660

ctgagcagca ccggcctgtg cctgatcaac gaggacggca gcgtgctggc ctacctggtg      720

gccgatatcc tgtgcaagaa cacctacggc atcatcaacg ccaacaccct gttcagagtg      780

ctggatggca agtggacccc cgagaccctg gaggaggccg ccaacaccta cggcatcatc      840

aacgccaaca ccctgttcag agtgctgaac ggcaagtggg agcccgagac cgaggaggag      900

gccaagaac                                                              909


<210>  20
<211>  882
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R1ACR_367-3

<400>  20
atgagctacg tggaggaccc cgccttcggc ttctacggca gctgggaggc cgccaaccag       60

gactgcatcg agagaggcct gagcaccacc aacaacacca gaatgatcca gctgctgttc      120

gccagcatct gcgcctgcca ggtgctgttc atggccagca gagcccccag agtgacctgg      180

gaggccgtgt acctgcccgt ggtggagacc gtgctgtacg gcatggccag caccggcaac      240

ggcagcatga gactggccga cggcagaatc gtgcccatcg ccagattctg cagctggctg      300

atcacctgcc ccatcatgct gttccaggtg gtgggcatcc acgagctgaa gtggagaacc      360

atcagctgca agaacatggt gatggccgcc agcctgatca gaaccgtgtt cggcatcggc      420

gccagcgtga ccatcacccc caccatgaga tgggtgcagt acttcctgag cctgagcttc      480

ttcctgttcg agctgatcgt ggtgtaccag atcttcagcg ccggcctgaa gaagttcggc      540

gccgtgaaga ccagcctgaa caacatcgtg tacagcagaa tcatgttcct gagattcctg      600

ttcttcctga gctggagcag cttccccatc atctggctgc tgagcagcac cggcttctgc      660

ctggtgaacg aggacgtgag cgtgctggcc tacctggtgg ccgacatgat ctgcaagaac      720

ctgtacggca tcaccaacgc caacaccctg ttcagagtgc tgaacggcaa gtggaccccc      780

gagaccgagg aggaggccaa gcagcccaag gacaacgagc acgcccacgt gggcgagacc      840

tacttcgagc agatgctgag cggcctgaga ggcagcagac ac                         882


<210>  21
<211>  948
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct GcACR_457-1

<400>  21
atgtccgcct gcccccccag gacacccaga tacggcaaca tgtccgctgc cgacaagagg       60

gccgagtacc tgcagaaggt catcgacctg agccctgaga tctatggcag ctacgccagg      120

gacaacgccg agtgcctcgc catgagcgtg gtcaccatgc ctttcgtgaa gatcacccag      180

ctgtgtatgg ccgtgatgag cgcctgccag gtcctgttca tgatcagcag agcccccaga      240

gtgccctggg aggccatcta tctccccgcc accgagatga tcagctacag cctggccttc      300

ttcggccagg gatatgtgag gctggccaat ggcaaagtgc tgccctggtg cagaatggcc      360

gcctggctgt gcacctgtcc cattatgctg ggcctggtgt ccaacatggc cctcatcaag      420

tacaagagcc agcccctgaa ccccatgatg atcgccgcct ccatcatcag gacagtgttc      480

ggcatctccg ccaccatggc cgaaaccaac gacgtgatct ggacccactt tttcttcgcc      540

ttcgtgtgct tcattttcga gatgtcctgc gccttcgcca tcttcgccct gaccatcgac      600

gacttccagc agattggcag ccctctggcc atgaaagtgg tgaagaggct gtacctgctg      660

aggatggtgt tcttcggcac ctggagctgc tttcccatcc tgtggatcat cagcagcacc      720

tacatgtgcg tgatcgacga gaacgctagc gctctgctct acctggtggc cgatatctcc      780

tgcaagaact gctacggcct gctgctgtgg agcaccacct ggggcctgct gaacggcaag      840

tgggacagag agtatgccag gaacagggac gaagccggca tgctcatgga gaccgatgag      900

aagcagggcg tgatcgagcc tcccaaagag aacttcgacg tgaagctg                   948


<210>  22
<211>  1020
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct GcACR_439-1

<400>  22
atggccgaga ccggcgtgat cagaagccag gaagactact acaggctcgt ggagaacagg       60

gagacaatcg gcacatactg ggattcctcc ctggtgtacg gcgagtgggc caggaacaac      120

ggcaactgcc tcagacagtc cgaggtggac gtgcagttcg tgaagatcct ccagctctgt      180

atgagcgtgg tcagcagctg ccaggtgctg ttcatggtga gcagagctcc tctggtgccc      240

tgggaggcca tctacctccc catgaccgag agcattacct atggcctggc cttcaccggc      300

aacggctaca tcagactggc tacaggcaag atcctgccct gggccaggat ggccagctgg      360

ctgtgcacct gccccatcat gctgggcatg gtgtccaata tggccctggt caagtacaag      420

agccagcccc tgaaccccct gatggtggcc agctccatca tcagggtggt gttcggcatc      480

tccgccacaa tgagcgacga cagccagccc gccaaatggg tgttcttctt catcgccgtg      540

attttcttcc tcttcgagct gacctgcgtg tacgctatct tcggaatgac catcgccgac      600

tttgcccaaa tccagtcccc cctgggcgat gccgtggtct acaggctgaa catcctgagg      660

ggcatctttt tcgccagctg gacatgcttt cccatcctgt ggctggtgtc ctccaccagc      720

gcctgcctgc tggacgagaa tatcagcgcc gtgctgtacc tgatggccga cgccctctgt      780

aagaacagct acggcattgt cctgtggagc acaacctggg gcctgctgaa cggcaagtgg      840

gacagagagt atcccagaaa cagggacatc gacggcctga tgatggacat cgaccccgcc      900

aaggagaagc aactggagga gatgcccaac cagaacttcg acatcaagat catgggccag      960

accatcgctt ccgtgaagag aagctgcaga aggcctagag ccgatatgga gagccaggat     1020


<210>  23
<211>  1053
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct GcACR_203-1

<400>  23
atggccgcta ggctggccaa ggtggtgcac ctggccaggc tggtggtgct gttcgccgtg       60

atgctggacg ctcaggatac cggaagccag gccgtgggct ttcagcccga ggagagaatg      120

gtcgtgagag gcaaagccgc ctacatcgac ggcatcggcc ctgccacacc ttatgccggc      180

atgtatggag agtgggagat cgccaatcct gattgcgtga acaagggcct gcacgccacc      240

agcagggaga gaaccatcat taccctgtgg gccgtggtgt gcctctgtca ggctctcttc      300

atgatgacaa gggcccctaa ggtgacctgg gaggccgtgt acctgcctct ggtggagtgt      360

atcctgtact gctgcacagg agccggatac ggcgtgctga ggatgggcga tggcagaatg      420

ctgcccctga gcaggatgtg ctcctggctg atcacctgcc ccatcatgct ctcccaggcc      480

tttggcatcc acgacatgaa gctgtacgga atccagctga ggatgcccat ttgcgccgcc      540

tccctcatca ggacagtgtg cggcctgctg gccagcacaa ccaccgatac caagatcgcc      600

aagtggctgt tcttcttcct gggctttagc ttttacacca tggagatcac caccgtgtgg      660

ttcatcttcc agcagggcat cgccaagttt acccccacca ccgatgtgcc tgagaacgcc      720

accgccctga gaaggctgta cttcatgagg ttcatttttt ttaccagctg gaccgccttc      780

cccgtgtttt gggtgctgag cagcaccgga ctgtgcgtca tcagcgaaca gacaagcgct      840

ctcggctacc tgtgcgccga cgctctgtgc aagaacctgt acggagtgat ccagaccaac      900

accgtgtggg gcctgctggg aggaacctgg acccccaaga agcaccccaa caatcacgat      960

gaggaggctc ccgccaacag ccacaaccac aaggaggaag acaccttcgc cgcccctcac     1020

ggcaggttca actccgccaa agagatcgag gat                                  1053


<210>  24
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct GcACR_243-1

<400>  24
atgattatca ccctgtgggc cgtggtgtgc atgtgccagg ccctgttcat gatgaccagg       60

gcccccaagg tgacatggga ggccgtgtat ctgcctctgg tggagtgcat cctctactgc      120

tgcaccggcg ccggatatgg ccagctgagg atgggcgatg gcaggatgct gcccctgagc      180

agaatgtgca gctggctgat cacctgtcct atcatgctgt cccaggcctt tggaatccac      240

gacctgaagc tgtacggcat ccagatgagg atgcccattc tggccgccag cctcatcaga      300

agcgtctgtg gcctgctggc ctccaccacc accgacacca aggtggtgaa gtggtttttc      360

ttctttctgg gcttctgctt cttctccatg gagatcggct ccgtgtggtt catcttccag      420

cacggaatcg ccaagttcgc ccctacaacc gacgtgcccg agaatgccac agctctgaac      480

aggctgtaca tcatgagggt gatcttcttc agcagctgga ccgcctttcc cctgttctgg      540

gtgctgtcca gcaccggcct gtgcgtgatc agcgagcaga caagcgccct gggctacctg      600

tgcgccgatg ccttctgcaa gaacctgtac ggcgtgatcc agaccaatac cgtgtggggc      660

gtgctgggag gcacatggac ccccaagaaa cccccctcca aagatgacga ggaggccccc      720

accaactccc acaacgacaa ggagatggac gccttcaccg ccccccatgg caggttcaat      780

tccgccaaag agatccagga cacctacaat agcgacacct acttcatcag ggccgccaag      840

gccgtgagcg tgaggatgtc cagaaagaag ggc                                   873


<210>  25
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct ZipACR/PsuACR_973-1

<400>  25
atggccgccc tccatcaggc tctggaggag ctgggacagg gagccagcag gcacctcctg       60

tacagagccc ccgaggagat ggtgtatggc aagtgggtgg aggccaaccc taggtgcatc      120

gaactgcacg accactccga ctacgtgtac gtgttccagc tgtgcttcgc cgtggtgtgc      180

gcctgccagg tgatcttcat gttcaccagg gcccccaacg tgggctggga agccatctat      240

ctgcccctgg ccgaggtcgt gacctacagc attgccgcca acggagaggg cgtgctgagg      300

atggccgacg gcaggtactt caatttcgcc aaactggccg gatgggccgt gtgctgcccc      360

attatgctca tccagatcgg aggcatggcc cagatcaagt acaggaccat ccccctgaac      420

aacgtggtgc tggccgctag cctgaatagg atcatcttcg gcatggccag cgccatcaca      480

gcctccgacc ctgctagatg gggcttttac ttctgcgcct ggatctgtta cctgaccgag      540

gtcggcatca ccctgaccat catggccgtg gccatcagcg acttcagcaa gatcaagaca      600

gagctcggcc agtgggtggt gggccgtatt caaaccatga ggatcatctt tctggtcgcc      660

tggaccagct tccccgtcgt gtgggtgctg ggctacaccg gattctgcgt gatccacgag      720

gactacatcg ccctgctgta tctgttcgcc gacctgctct ccaagaacac ctggggagtg      780

atgatgtggc ataccacctg ggtgaaactc aacggcaaat gggacaggga atttgccgcc      840

gccggaggac acgaggctct gaagaaggcc ctggagcagg acgtggaaat cggcgccggc      900

gagaagaacc agaaccagct gaccgccagg cag                                   933


<210>  26
<211>  903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct PsuACR_433-1

<400>  26
atggctgagc tggtggacga gtacggcctg tgggccctgg agaaccccga gtgcatggag       60

atgtcctaca ccagccccaa caccaaaacc gcccagctgt gcttctgcat ggtgtgcctg      120

tgccagatca tctggatcat gggacagtgg cccaaagtgg gatgggaaag catctacctg      180

cccgcttgcg agatgacact gtattccctg gccgcttccg gcaatggctt catccagctg      240

gccgacggca ggatcatccc ttatgccagg atggccgcct ggatttgtac ctgtcccgct      300

ctgctgatgc agatcaacgg cctggccaag tgcaagctgg gccacttcaa cctgaacacc      360

ttccaggtgg tggccgatct gatcatgaac gtgatgggac tgaacgccac actcaccaac      420

cacacctacc tgaagtggat ctacttcggc attgccatgg tgctcttcgg atgcatcatg      480

ggcatcaccc acgatatctt ctcccagacc gctaggaagt ggaagtccgt ggacacaccc      540

ctggcccaga aggtcgcctg gagggtcacc ttcctgaagt acctgttcag cctcagctgg      600

agcatctacc ctctgctgtg gattttatcc ccccaggcca cctgtagcct gagagaagac      660

gtgatctcct gcctgcactt cgtgtccgac ttcttcgcca agaacatctt tggcctggtg      720

atgtggtgga ccctctggag agacctggac ggcgactgga gcttcgagca ccactacccc      780

cccgatcagg agcaggctag gagctccgct agcgccacac actccctccc cggcaagagc      840

attggcctgg ccgagagcat caacttcgtg aaggacaccc aggactgcca cgatcacgat      900

ggc                                                                    903


<210>  27
<211>  891
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R1ACR_477-1

<400>  27
atggccctgt acacctccca gtttggcatc gcctacggca gctgggaggc cgagaacgac       60

gattgcctga gcatgggcat cgctagcgga gcccccgtga agatcatcca gctgtgttgg      120

gccgtggtga gcctgtgcca ggtgattttc atgctcacaa gggcccccag ggtggcttgg      180

gaagccatct acctgcccct gtgcgagacc atcacctact tcctggcctt cagcggcaac      240

ggctacctga ggatggccga cggccagatc ttcccttggg ccaggatggc cagctggctg      300

gtgacctgcc ctgtgatgct gggccaggtg agcgccatgg ccctgatcaa gtacaaaagc      360

ctgcccctga acaatatgat ggtggccgcc tccctgatca gggtggtgat gggcatctcc      420

gccaccatca cacccaacga gcagctgaag tggatgttct tctttttcgg cgtgagcatg      480

ctgacctttg agtatttctg cgtgttcacc atcttcagca tcaccatcgc cgacttccag      540

gagatcgaca cacccaggtc caggttcgtg gtcggcaggc tgaagatcct caggattgtg      600

ttccactccg cttggacagc cttccctatc ctgtgggtgg tgtccagcac cggcctgtgc      660

gtgctcagcg agaatatctc cagcgtgtgc tacatgctcg ccgacgccgc ttgtaaaaat      720

ggctacggac tggtcctgtg gaacaccacc tggggccacc tgaacggcaa gtgggataga      780

gagttcgcca agaatgccga caaggacgga gagatgaagg ccatcgagga aggagctgct      840

ggacccgccg ctgacgccaa gaaggacgag gatatcaagc tgttcggcaa g               891


<210>  28
<211>  825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct RsACR_995-1

<400>  28
atgggcatcg ccagcggcgc ccccgtgaag attatccagc tgtgctgggc cgtggtcagc       60

ctgtgccagg tgatcttcat gctgaccagg gcccctaggg tggcttggga ggccatctat      120

ctgcccctgt gcgagacaat cacctacttc ctggccttca ccggcaacgg ctacctcagg      180

atggccgacg gccagatctt cccctgggcc aggatggcct cctggctggt gacctgccct      240

gtgatgctgg gccaggtgtc cgccatggcc ctgatcaagt acaagagcct gcccctgaac      300

aacatgatgg tggctgcctc cctgattagg gtggtgatgg gcatcagcgc cacaatcacc      360

cccaacgagc agctgaagtg gatgtttttc ttcttcggcg tctccatgct gaccttcgag      420

tacttctgcg tcttcaccat cttctccatc accatcgccg acttccagga gatcgacacc      480

cccaggagca ggctggtggt gggaaggctg aagatcctga gaatcgtgtt ccacagcgcc      540

tggaccgcct tccccatcct ctgggtggtg agcagcaccg gcctgtgtgt gctgagcgag      600

aacatcagct ccgtgtgcta catgctggcc gatgccgcct gcaagaacgg ctacggcctg      660

atcctgtgga acacaacatg gggccatctg aacggcaagt gggacaggga gttcgccaag      720

aacgccgaca aggatggcga gatgaaagct atcgaggagg gcacagccgg acctgccgcc      780

gacgccaaga aggacgagga catcaagctg tttggcaagc ccgtg                      825


<210>  29
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R1ACR_877-1

<400>  29
atgagcgcca ccgaaaaccc tgccttcggc ctgtacggca cctgggagaa cgaccacccc       60

cagtgtgtgg agatgggcct ggacaccagc agccagacaa acatgatcca cctcctgttc      120

gccagcatct gcttctgtca ggtgctcttt atggcctcca gagctcccag agtgacctgg      180

gaggccgtct acctgcccct ggtggagacc gtgctgtacg gaatggccgc cagcggcaac      240

ggcaacctga ggatctccaa cggcaggatg gtgcccatgg ccaggttctg cagctggctg      300

atcacctgtc ctatcatgct gctgcaggtg gtggtgatgc acgacgtggt gtggttcaac      360

gtgagcacca ggtacatggt gctggccgcc agcctgatca ggaccgtgtt cggcatcggc      420

gccagcgtga ccaccaacga taccatgaga tgggtgcagt tcctgctgtc ctgcatctgc      480

ttcgccttcg agatggtggt ggcccaccag acctacaagg gagccctgaa gaagtttgcc      540

gccgtgaaga ccaccctgaa cggcgtggtc tacgccagga tcatgtttct gaggttcctg      600

ttcttcttca gctggaacgc cttccctatc atctgggccc tgagcagcac aggcctgtgt      660

ctgatcagcg aggacgccag cgtgctgtcc tatctcgtgg ccgacctgat ctgcaagaac      720

atctacggca tcaccaacgc caacaccgtg ttcagagtcc tggacggagc ctgggtccct      780

gagaccgagg aacacgccca ggccaaggac cacctgacct acctcgagat gatgatgaac      840

cacaacctgg gcatcggcag acatcatgac gaggagctgc aaatggaagt gggccatgac      900


<210>  30
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R1ACR_447-1

<400>  30
atggtgtggt cccatgtgga cgagcctgcc ctgggaccct atggcagctg ggaagccgcc       60

aaccccgatt gtgtggccct gggcctgacc acctccaaga acaccaagat gatcctcctg      120

ctgttcgcca gcatttgcgc ctgtcaggtg ctgttcatgg ccagcagggc ccctaggatt      180

acatgggagg ccgtctacct gcctctgatc gagaccatcc tgtacgctat ggccagcacc      240

ggcaatggcc agctgaggct gggagacggc agggtgctgc ctatcgccag gtactgctcc      300

tggctgatca cctgccccat catgctgttc caggtggtgg gactctacga tctgaagctc      360

tggggaatct cctgcaagca catggtgatg gccgccgccc tgatcagaac cgtctttgga      420

atcggcgctt ccgtgacact ggatgaccag atgaggtggg tgcagttctt tctgtcctac      480

gccttcttct tctttgagct gtactgcgcc tacatgatct tcggcgctgc cctgaagcag      540

ttcggcgaag tgagaaccac cctgaatagc atcgtgtact ccaggatcat gctgctgagg      600

ttcattttct tcctgagctg gaacagcttc ggcatcatct ggctgctgag cagcaccggc      660

ctgtgcatga tttccgagga cgtgtccgtg ctggcctacc tggccgctga catgctgtgc      720

aagaacacct acggcatcat caacgccaac accctgttca gagtcctgga cggcaagtgg      780

acccccgaga cactggagga agccgcctcc ggcgtgaaga aggccaaccc caaccacgtg      840

ggcgagacat acctggagag gatgatggcc ggcattaggg gcagcgctaa gcccgaggag      900


<210>  31
<211>  891
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R1ACR_741-1

<400>  31
atgtcctacg tggaagatcc tgccttcggc ttttacggca gctgggaggc cgccaatcag       60

gactgcatcg agagaggcct gtccaccagc aacaatacca ggatgatcca gctgctgttc      120

gcctccattt gcgcctgcca ggtgctgttc atggcctcca gggcccctag agtgacctgg      180

gaggctgtgt acctgcctgt ggtggaaacc gtcctgtacg gcatggccag caccggcaac      240

ggcaacatga ggctggctga cggcaggatc gtgcctatcg ccaggttctg cagctggctg      300

atcacctgcc ccatcatgct cttccaagtg gtgggcatcc acgagctgaa gtggagaacc      360

atcagctgca agaacatggt gatggccgct agcctgatca ggaccgtgtt cggaatcggc      420

gccagcgtca ccatcacccc caccatgagg tgggtgcagt acttcctgtc cctgagcttc      480

ttcctgttcg agctgatcgt ggtgtaccag attttctccg ccggcctgaa gaaattcggc      540

gctgtgaaga cctccctgaa caacattgtg tactccagga tcatgttcct gagattcctg      600

ttcttcctga gctggagcag cttccccatt atctggctcc tgtccagcac cggattctgc      660

ctggtgaacg aggacgtcag cgtgctggcc tatctggtgg ccgacatgat ctgcaagaac      720

ctgtatggca tcaccaacgc caacaccctg ttcagggtgc tgaatggcaa gtggaccccc      780

gaaaccgagg aagaggccat gctgcccaaa gaccacgaac acgcccacgt gggcgagacc      840

tacttcgagc agatgctgag cggcctcaga ggcagcagga ggagggacca c               891


<210>  32
<211>  840
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct GcACR_197-1

<400>  32
atgcaggcct cccagatcag ctcctcttac tttggccagt ggtctgccac aaacatcgac       60

tgcgtggcca aggccgatat cagctccggc gtgcagacct ttctgctgtg cttctgtatc      120

atcagcgcct gccaggccct gtacttttcc tatcactgtc tgccacaggc aggagcacgg      180

agaaggagca catgggagtt catcgccgtg cctgcagtgg aggccctgtg ctacggcctg      240

gcatctagct cctctcaagt gggctacttc cggctgttcg acggaaggac cgtggtgtgg      300

ctgaggacag tgctgtggat tctgaccgtg ccagtgctgc tgctgcagat cggcaagatg      360

agctacgtgg tcatccaggg cgtggaagtg aattccctga tcatctttgt gggcctgctg      420

atggtggtgt ttggcttctc tgccagcctg tccaccgtga tgggcatcaa gtggatgttc      480

tttttctttg gcctggtgtg catggccgtg gtgttcctgg gcgtgtataa gatcatggtg      540

gacgccggct cctactatat ctccctgaac tctcaggatg gcctgcagat cgcctctcgg      600

atcagaatcc tgatgatcat cttctttttc tcttggaccg ccacacccct gttctgggtg      660

ctgagcatcg agggagcatg cgtggtgtct gagagcatca cagtggtgtg ctttgccgtg      720

atcgactccc tggccaagaa tatcttcggc atcatcctgt gggataccgt gtggaacagc      780

tccctggagg gccggtggac atctaatctg cagatcatgg ccaccgagat gagcatgctg      840


<210>  33
<211>  864
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct GcACR_201-1

<400>  33
atggaggcag cagacgagga ggatgtggga ggaggcgacc tgtggaacgt gaataccggc       60

tgcctgtatg gaaacctggc atccgcctct ccactggtga ggcacttcga gctggcatgg      120

gccgtgtgct gtctgaccca ggccttcttt aagtttacac agtggccaag ggcagcatgg      180

gagggcgtgt acatccctct gtgcgagaca gtgcagtatt ctctgctgtt ctttaagctg      240

ggctacatcc aagtgggagt gaaccaggga gcatacctgc catgggtgcg gtatagcttc      300

tggatgatca ccacacccgt gctgctgaat cagatccagc agatctgcga ggtgaagatc      360

tggggcgcca gaatgggccc tgtgcagacc tgggccaaca tcgccatggt gacactgggc      420

atctccggcg ccctgatcca gaatccaacc atgaagtggc tgtgcttcgt ggcaggcaca      480

ctgctgggcg ccctgatctt tctggtggcc ttcctgatct ttcacaaggc ctctgagcag      540

ttcaaggaga tcggccaccc caaggccgac agggtggtga agtacctgtg gtatctgcag      600

gtgtgcttct ttagctcctg gagcgtgttt cctctgctgt ggatcatctc cgcccagggc      660

acctgtatcg ccaacgagga catcgtgtct agcatccaca tcccagccga tatcctggcc      720

aagaacgtgt tcggcctgat catctggcac atccggtttc acctgtgcga cggctactgg      780

gatatcgaga gattcaagca gaagctgctg caggacaagc tgctggccct gtttgataat      840

cctgaggagc tgagacagga tcac                                             864


<210>  34
<211>  855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct HpACR_213-1

<400>  34
atgaccgtga tctacggaca gtgggcagca cagaacccag gatgcgtgtc tatgaccaat       60

atcgacctgg gcgtgaggac attcgagctg tgctggggca tcatgtgcgc ctgtcaggcc      120

gtgttctttg cactgaggta cccaagggca acctgggagt tcgtgatggt gcctctgaca      180

gagtgcttta tctacggcct gggctattcc gagatcggct atatcctgct gtgggacggc      240

cggcaggtgc tgtggaccag aacagtgctg tggctggcca ccgtgcccat cctgctgaac      300

cagatcaatg ccatggccgc cgtgcacatc tacggcgtgg atctgaacat catgcagatg      360

tatttctcca cactgatgat ctgcctggga cacaccgccg ccctgacaca caatcagtct      420

ctgaagtggc tgttctttat catggccatg gccatcttcg gcgtgatctg ttttatcaac      480

tactatacct tcgccgccgc cgagaagcac tacaaggaga gcggctccga gaatgatctg      540

aagatcgcca agcggatcag actgctggcc atcatcttct ttacctcttg gacaatgtat      600

cccctgttct ttgtgctgag cgtggaggga gcatgcgtgg catctgagag cgtgatcctg      660

gtgtgctttg ccctggccga cctgctgagc aagaacgtgt tcggcgtgct gttttgggac      720

accctgtgga atatgcagga tggcaagtgg acatcctacg gcaccgtgac attctttaag      780

accacagata gcgtgaccaa gacagccatc tccacagcca tggaggagga gtattccaag      840

cagaaggtgt ctaga                                                       855


<210>  35
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct HaACR_359-1

<400>  35
atggcaaccc cagcacctgc aggagcacca ctgaccacaa ccccagtgcc atacggacag       60

tgggaggcaa acaatcctgc ctgcgtggcc ctgttcacaa tgccagccca ggtgcagacc      120

ctgatgctgt gctggtgtat catctgctct tgtcaggcca tctttctgat gagcaggtgg      180

ccaagagtgg gatgggagct ggtggcagca ccagcaatcg agtccatcgt gtacggcctg      240

ggctatcagg gcatcggcta cgtgaagatg gcctctggcc agcctctggc ctatgccagg      300

ttctttatga tgatcacaat caccccaatg atcctgctgg acatcaacaa gctggcaagc      360

gtgcgcctgc tgggcctgaa catgaattcc atgcagctgg gcgccaatgt gctgctgtgg      420

atgttctggc aggccagcac aatgtccacc ctggtgggcc tgaagtgggt gttctttgtg      480

ctgggcctgc tgtgcctggg cctggtgctg ggcacatctt tcatgatctt tgctgccgcc      540

cggcagagct ttctgctgaa gggaacagga gcaggcgact gggtggcaca gagaatcacc      600

tacctgcaga tggccttcct gcccacatgg accgcctata tggtgctgtt tgtgctgagc      660

ggagagggag catgtatcgc aggagagggc gtgatcctgc ctatcgccat cgtgatggat      720

ctgttccaga agaacgtgca cggcctgatc atctggtcca ccttctggaa ctttctggga      780

ggctcttgga atccagagcg gctggcagag gagagggcac cttccaggat cgcaggcctg      840

aaagtgatcg agaacaatgc ccaccctgtg gat                                   873


<210>  36
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct HrACR_495-1

<400>  36
atggcaacac caggacctgc agcagtgcca tccatgacca caaccccagc accatacgga       60

acctgggagg caaacaatcc atcttgcgtg gccctgttca acagctcccc ccagatccag      120

acactgatgc tgtgctggtg tatcatctgc acctgtcagt ctatctttct gatgagcagg      180

tggcctagag tgggatggga gctggtggca gcaccagcag tggagtgtat cgtgtacggc      240

ctgggctatc agggcatcgg ctacgtgaag atggcctctg gccagcagct ggcctatgcc      300

aggttcttta tgatgatcac agtgaccctg atgatcctga tcgacgtgaa caagctggcc      360

tctgtgcgcc tgctgggcct gaacatgaat agcatgcagc tggccgccaa tctgctgctg      420

tggatgttct ggcaggcctc tacaatgagc accctgtccg gcctgaagtg ggtgctgttt      480

gtgctgggcc tgatctgcct gggcatcgtg ctgggcacat ccttcatgat cttttctgcc      540

gcccggcagg gcttcctgga caagaatacc ggagcaggcg attgggtggc acagagaatc      600

gtgtttctgg aggtggtgtt ctttcctaca tgggccggct acatggtgct gtatgtgatc      660

agcggagagg gagcatgtat cgcacctgag acagtgatca tcccagtggc catcgtgctg      720

gatctgttcc agaagaacgt gcacggcctg atcatctgga gcacattctg gaactttctg      780

ggcggctcct ggaatccagg ccggctggca gaggagaggg cacctagccg cctggccggc      840

ctgaaagtga tcgagaatac cgcccacggc ttcgacgatg aggccctgtc cgagggcttt      900


<210>  37
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct PsuACR_353-1

<400>  37
atggaggtgg agatggagat ggagatggag ggcctgggca acagcacatc catgttcgag       60

gaggtggtgg gatgcgatct gggagcaagc ccagtgggcg agacagagat gcacgtggtg      120

cagtggatcg gcagcttcat ctgcatcttt cagtgtctgt ggttcctgtc caagtggcct      180

aactttacct gggacacacc atacatccct gcagtggagg cagtgggata tggcctgatg      240

gccaatggct tcggctacgc cgagctgttt gagggcgagc ggcacgtgcc ttggctgaga      300

tattccatct gggtgctgtc tacaccagtg ctgctgtggg acatccagga tatcctggac      360

gccttctaca ggggaaccag actggcacct gtgcagtctc tggccaatct gtttctgctg      420

tgcttcggct ttatcggcgc catcgagcac gtgctggccg tgaagtacct gtgctatagc      480

atcggcgtga tgatgctggg cgtggtgttc ttttgtgcct ataacatcgt gggccaggcc      540

gtggccaatt tcgaggccac cgatacagca cagggcaggc tggtggcctt tcgcctgaag      600

ctgatcgcct gcatcttcat gacatctttt agcggctacc caatcctgtg gattctgtcc      660

aaccagggcc tgtgcctggt gccagagatg atcatcgagg tggtgcacat ccccctggac      720

ctgatcgcca agaacctgtt taccctgctg acatggcaca cccactatat cctgctgaat      780

ggcgattggt cttgcgaggc aatggtggca aggctgcagg agcagaatga catcgagatg      840

gcacagcagc caagggaggc aggacagctg cgcaaggatc tgatgcagaa ggcccagggc      900


<210>  38
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct RaACR_687-1

<400>  38
atgggcgaca tgtcccacat cgagacagtg tactatgtga acggaaccga ggtggacccc       60

tggacacaca ggtgccagct gggagtgcct ggaggctccc agggcatcca caccttccag      120

ctgacatgga gcctgatctg taccgcccag gccatctttc tgatgacaaa gtggccaaaa      180

gtgggctggg aggccatcta catgccctgc tgtgaggccc tgtcttatgg cctgctgagc      240

gccggacacg gatacctgaa gctgcacggc gagtggcact acatcccttg gatcagatat      300

gccgcctgga tggtgaccac accagtgctg ctgaatcagg tgcagggcgt gctggacgtg      360

aaagtgggcc acctgagact ggccccaatc cagagcctgg ccaacctgat catgatcgtg      420

atgggcgtgt ccgcccacct gcaggagaat atcgcctgga agtgggtgtt ctttctgatc      480

ggctgcgtga tggccctggt catctactgg gtggcctggc tggtgttctc tacccagatc      540

aagtactatg ccgagacaaa gacagccgtg ggcgataggg tggtgtttca gctgaagctg      600

atcgccgtgg ccttctacgt gggctggtct gcctttcccc tgatctggat gctgagctcc      660

gagggcctgt gcgcaatcga ggagcacatc gctgccgccg cccacatccc tgcagacgtg      720

ctgagcaaga acatcttcgg cctgctgatg tggcacacaa ggtggatcgt gctgggcggc      780

tattgggatg tgaataagtt taaggagaca atcgcccagc agaagctgga ggaggccaag      840

ggcgaggaga caccccagga gaagaggaag gccctgatgg gacaggcaga ggcctgcttc      900

aagatggccg acgcctgt                                                    918


<210>  39
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R1ACR_497-1

<400>  39
atggagtacc agagcctgga cgattttcca ctggagacac tgtacttccg gaacggcaca       60

gaggtggacc cctatgatca cagatgcaag ctgggcatcc ctggaggctc ccagggcatc      120

cacacctttc agctggtgtg ggcactgctg tgcgcagcac aggccctgtt tctgttctcc      180

aagtggccaa aagtgggctg ggaggccatg tacatgccct gctgtgaggc cctgtcttat      240

ggcctgctga gctccggcta cggctatatg aagctgcacg gcgagttcca ctacctgcct      300

tggatcaggt acgccgcctg gatcgtgacc acaccagtgc tgctgaacca ggtgcagggc      360

atgatcgaca tcaagatcgg ctctctgagg ctggcaccaa tccagagcct ggcaaacctg      420

atcatgatca tcatgggcgt gagcgcccac ctgcaggaga atcacgcctg gaagtggctg      480

ttctttttcg tgggctgcgt gatgtgcgcc gtgatctact atatcgcctg gctgcagttt      540

gccaaagtga atgagctgta cgccgccacc aagacagaga tcggcgataa ggtgtgcttt      600

cagctgaagc tgatcatgtt ttgtttctat gtgggctggt ccatgttctc tgtgatctgg      660

ctgctgtcta gcgagggcct gtgcctgatc gaggagcaca tcagcgccgc cgcccacatc      720

ccaggcgaca tcctgagcaa gaactccttt ggcctgctga tgtggtatac caggtggatc      780

acactgggag gagcatggga tatcaataag ttcctggaga agcaggccaa ggagaaggcc      840

gaggccgtgc tgacacctgc cgagaagagg aaggccatca tgaagcaggc agaggcatgc      900

ttctccatgg cagacgcctg tctgcagcag gccaat                                936


<210>  40
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct RsACR_665-1

<400>  40
atggactaca ccagcctgga cgattttcca ctggagacac tgtacttccg gaacggcaca       60

gaggtggacc cctatgatca cagatgcaag ctgggcatcc ctggaggctc ccagggcatc      120

cacacatttc agctggtgtg ggcactgctg tgcgcagcac aggccctgtt tctgttctcc      180

aagtggccaa aagtgggctg ggaggccatg tacatgccct gctgtgaggc cctgtcttat      240

ggcctgctga gctccggcta cggctatatg aagctgcacg gcgagttcca ctacctgcct      300

tggatcaggt acgccgcctg gctggtgacc acaccagtgc tgctgaacca ggtgcagggc      360

atgatcgaca tcaagatcgg ctctctgagg ctggcaccaa tccagagcct ggcaaacctg      420

atcatgatca tcatgggcgt gagcgcccac ctgcaggaga atcacgcctg gaagtggctg      480

ttctttttcg tgggctgcgt gatgtgcgcc gtgatctact atatcgcctg gctgcagttt      540

gccaaagtga atgagctgta cgccgccacc aagacagaga tcggcgataa ggtgtgcttt      600

cagctgaagc tgatcatgtt ttgtttctat gtgggctggt ccatgttctc tgtgatctgg      660

ctgctgtcta gcgagggcct gtgcctgatc gaggagcaca tcagcgccgc cgcccacatc      720

ccaggcgaca tcctgagcaa gaactccttt ggcctgctga tgtggtatac caggtggatc      780

acactgggag gagcatggga tatcaataag ttcctggaga agcaggccaa ggagaaggca      840

gaggccgtgc tgacccctgc cgagaagagg aaggccatca tgaagcaggc cgaggcctgc      900

ttctccatgg ccgatgcctg t                                                921


<210>  41
<211>  855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R1ACR_653-1

<400>  41
atgccatacg ataactatgg ctggtgggag cgggagaatg ccgactgcat ctctaagatg       60

gatgccaagc tggaccagat gcacctggtg cagctggcca tgtccatgct gtgcttttgt      120

cagctggtgt tcatgacctc tagatttcca aagcaggcat gggaggcaat ctacctgcca      180

gcagcagagt gcgtgctgta tgcaatggca gcaagcggaa acggatacct gaggctggca      240

aatggccgcc tgctgccatg ggcaaggatg gcatcttggc tggccacctg tcctgtgatg      300

ctgaaccaga tcaatacaat cagcccactg aagctgtatg gcatcaacct gaacaatgtg      360

cagatcgccc tgtccgtggt gcgcgtggtg aatggcgtgt ctgccagctc cgtggacgat      420

gacagcctga agtggggctt ctttttcatg ggcgtgttct gcctggtcat cgagttttcc      480

atcgcctaca acatcttcgc cctgggcatg gccaagttta aggaggccgg caaggattct      540

gacatctgcg cccgggcctg tgatagactg caggtgctgc ggggcatctt tttcagcgcc      600

tgggccatgt tccccatcat ctggctgttt tcccctcagg gaacctgtct gctgggagag      660

gatgtgatcc ctctgctgta tctgttcgcc gacctggtgt gcaagaattg ttttggcatc      720

ctgtggtacg ataccacatg gaggctgctg gacggcaagg gatggaaccc cgagctgcag      780

ctgacagaca atgaggtgga ggagctggtg cacgccaagg aagaggtgga ggatcaccac      840

caccctcacg acgcc                                                       855


<210>  42
<211>  891
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R1ACR_6367-1

<400>  42
atgtctgcca tcacagaccc cgccctgggc ctgtacggaa cctgggaggc cgccaacaag       60

gagtgcgtgg ataagggcgt ggagtttagc tccaataccc ggatgatcgt gctgctgttt      120

gccagcgtgt gcttctgtca gacagtgtat atgaccagca gggcaccaag ggtgaactgg      180

gagggctgct acctgcctct gtgcgagaca tttctgtatg gcctggcagc aagcggaaac      240

ggaatgatcc ggctgtccaa tggcagaatg gtgccaatgg ccaggttctg ctcctggctg      300

gtgacctgtc ccatcatgct gatgtctgtg ctggccatcc acgacgtgcg ctggatgggc      360

gtgcctgtga agaatatggt catcgcagcc acactgatca ggaccgtgct gggaatcgga      420

gcatctagca ccatcacaga gacactgaga tgggtgcagt actgcatcgc ctgtgccgtg      480

ttcgtgttcg agctgacaat ggtgaaccag ctgtttatcg ccggcctgca gaagttcggc      540

gtggtgaaga ccaagctgaa tgacatggtg tatatgagga tcatgatcct gcgcgccctg      600

ttctttttca gctggacagc ctttcctgtg atctggattc tgtcctctac cggcttctgc      660

gtgatcggag aggacggctc cgtgctggca tacctggtgg ccgacttcct gtgcaagaac      720

gtgtatggca tcatcaacac aaataccctg ttccaggtgc tggatggcga gtggaagcca      780

gagacaaggg acaccgatgg caagatcgcc acaaatcgcc acgcccacat cggcgagaca      840

tacctggaga tgctgctggc ccggatcaga cggcacagag agggcgagct g               891


<210>  43
<211>  915
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R1ACR_591-1

<400>  43
atggtgtggt cccacgtgga cgagcccgcc ctgggacctt acggctcttg ggaggcagca       60

aaccctgatt gcgtggccct gggcctgacc acaagcaaga ataccaagat gatcctgctg      120

ctgttcgcct ctatctgcgc ctgtcaggtg ctgtttatgg ccagccgggc ccctagaatc      180

acatgggagg ccgtgtacct gccactgatc gagacaatcc tgtatgccat ggcctctaca      240

ggcaacggcc agctgaggct gggcgacgga cgcgtgctgc caatcgcacg gtactgcagc      300

tggctgatca cctgtcctat catgctgttc caggtggtgg gcctgtatga tctgaagctg      360

tggggcatct cctgcaagca catggtcatg gccgccgccc tgatcaggac cgtgtttggc      420

atcggcgcca gcgtgacact ggacgatcag atgagatggg tgcagttctt tctgtcctac      480

gccttctttt tctttgagct gtactgtgcc tatatgatct tcggcgccgc cctgaagcag      540

tttggcgagg tgaggaccac actgaactcc atcgtgtatt ctagaatcct gctgctgaga      600

ttcatcttct ttctgtcttg gaatagcttt ggcatcatct ggctgctgag ctccaccggc      660

ctgtgcatga tcagcgagga cgtgtccgtg ctggcatacc tggcagccga tatgctgtgc      720

aagaatacct atggcatcat caacgccaat acactgttcc gcgtgctgga cggcaagtgg      780

accccagaga cactggagga ggcagcatcc ggagtgaaga aggcaaaccc caatcacgtg      840

ggcgagacat atctggagag gatgatggca ggcatccgcg gctctgccaa gccagaggag      900

gaccccgtgg ccgcc                                                       915


<210>  44
<211>  819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R1ACR_053-1

<400>  44
atgggcctgg acaccagctc ccagacaaac atgatccagc tgctgtttgc ctccatctgc       60

ttctgtcagg tgctgtttat ggcctctagg gcaccaagag tgacctggga ggccgtgtac      120

ctgccactgg tggagacagt gctgtatggc atggccgcca gcggcaacgg caatctgagg      180

atctccgacg gccgcatggt gcctatggcc aggttctgca gctggctgat cacctgtcca      240

atcatgctgc tgcaggtggt ggtcatgcac gatgtggtgt ggtttaacgt gtctaccagg      300

tacatggtgc tggccgccag cctgatccgc acagtgttcg gcatcggcgc cagcgtgacc      360

acaaatgata ccatgcggtg ggtgcagttt ctgctgtcct gcatctgttt tgccttcgag      420

atggtggtgg cccaccagac atacaagggc gccctgaaga agttcgccgc cgtgaagacc      480

acactgaacg gcgtggtgta tgcccggatc atgtttctga gattcctgtt ctttttctct      540

tggaatgcct ttcccatcat ctgggccctg tctagcaccg gcctgtgcct gatctccgag      600

gacgcctccg tgctgtctta cctggtggcc gatctgatct gtaagaatat ctatggcatc      660

accaacgcca atacagtgtt ccgggtgctg gacggagcat gggtgccaga gacagaggag      720

cacgcacagc ctaaggatca cctgacatat ctggagatga tgatgaacca caatctgggc      780

atcggcagac accacgacga ggagctgcag atggaggtg                             819


<210>  45
<211>  906
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct C1ACR_561-1

<400>  45
atggagatca acaccacaag cccatacgga tggtgggctg ccgccaatcc agagtgcgtg       60

gcaaaggcag cagtgaccgt ggacatccag atctttcagc tgtgctggtg tatcatctgc      120

gcctgtcagg ccttcttttt cgccatccgg taccctaagg tgacctggga gttcgtgctg      180

gtgccactga cagaggccgt gatctacggc ctgggctata gcggcatcgg ctatgtggtg      240

ctgcagtccg gccggaccgt ggcatggatg agaatctgcc actggctgat cacagtgcca      300

gtgctgctgc tgcagatcag cgacgtggca cacgtgcggt ttcacggagt gaacctgagc      360

tccctgcagg tgcccatctc cgtgctgatg atcgtgtttg gcttctgtgc cgaggtggcc      420

gatgaggagg gcgtgaagtg gatgtttttc gtgatcggcc tggtgctgat gtttcaggtg      480

ctgttcgtgg gctaccactc tctgagcagg ggcatcaccc gcttctctga ggcaggaaca      540

gaggagggag caatggtggc aaacaggctg agagccatgc tggtgttttt cctgctgtct      600

tggacactgc accccctgtt tttcgtgctg agcatcgagg gcgcctgcgt gatgaccgag      660

cctgtgacag tggtgctgta tatcgtgctg gacctgtttg ccaagaatat cttccagatc      720

gtgctgtggg attccctgtg ggtgaggctg accggcaagt ggaaggtgga ggagctggtg      780

gtgcacgacg catccgccga gctgggctac gacgaggatt ataagcacga tgagatcaac      840

ctgtctatcg gcaatgtgcc cgtgagcaca gagtctcccg tgcctcgcgg cgccggcgag      900

ggcgcc                                                                 906


<210>  46
<211>  888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R2ACR_853-1

<400>  46
atgagcgccg tggccgatcc ccagtttggc ctgtacggca cctgggaggc ctccaacatg       60

gattgcgccg ccatgggccc caccattacc tccaccacca agatcttcca gctgctgttc      120

gcctgcatct gcgcctgtca ggtggtgttc atggccagca gggcccccag agtcacatgg      180

gaggccgtgt acctgcccct ggtggagacc attctgtaca gcgtggccgc caccggcaac      240

ggcaacatga gactcagcga cggcagggtg gtccccatcg ccagattctg cagctggctg      300

atcacctgtc ccatcatgct gttccaggtg gtgggcatcc atgagctgaa gtggatgggc      360

gtgagctgca agaatatggt gatggccgcc accctgatcc agaccgtgta cggcattggc      420

gccagcgtga tcagcaacaa cttcatgaag tggttcctgt tcttcctggg ctgcatctgc      480

ctggccttcg acttctttct ggtcagcagc attttcgccg ccggcctgaa gaagtttggc      540

gccttcaggt ccaagctgaa caacatcgtg tacaacaggc tgatgttcat gaggagcctg      600

ttcttcttcg cctgggtgag cttccccatc atctggacac tggcccccac cggcatctgc      660

atgatcaatg agaacgccac cgtgctggcc tacctgatcg ctgatatgct gtgcaagaac      720

atgtacggca tcatcaacgc caataccctg ttccaggtcc tcaacggcag ctggaccccc      780

gaaaccctgg agtccagcaa gctgcctcag aaaaacgaag tgcacgagac ctacatcgat      840

atggccctgg atagctggag gggcaaggcc agcgaggaga cagaggct                   888


<210>  47
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic rhodopsin (7 TM) domain (R1ACR_853)

<400>  47

Met Ser Ala Val Ala Asp Pro Gln Phe Gly Leu Tyr Gly Thr Trp Glu 
1               5                   10                  15      


Ala Ser Asn Met Asp Cys Ala Ala Met Gly Pro Thr Ile Thr Ser Thr 
            20                  25                  30          


Thr Lys Ile Phe Gln Leu Leu Phe Ala Cys Ile Cys Ala Cys Gln Val 
        35                  40                  45              


Val Phe Met Ala Ser Arg Ala Pro Arg Val Thr Trp Glu Ala Val Tyr 
    50                  55                  60                  


Leu Pro Leu Val Glu Thr Ile Leu Tyr Ser Val Ala Ala Thr Gly Asn 
65                  70                  75                  80  


Gly Asn Met Arg Leu Ser Asp Gly Arg Val Val Pro Ile Ala Arg Phe 
                85                  90                  95      


Cys Ser Trp Leu Ile Thr Cys Pro Ile Met Leu Phe Gln Val Val Gly 
            100                 105                 110         


Ile His Glu Leu Lys Trp Met Gly Val Ser Cys Lys Asn Met Val Met 
        115                 120                 125             


Ala Ala Thr Leu Ile Gln Thr Val Tyr Gly Ile Gly Ala Ser Val Ile 
    130                 135                 140                 


Ser Asn Asn Phe Met Lys Trp Phe Leu Phe Phe Leu Gly Cys Ile Cys 
145                 150                 155                 160 


Leu Ala Phe Asp Phe Phe Leu Val Ser Ser Ile Phe Ala Ala Gly Leu 
                165                 170                 175     


Lys Lys Phe Gly Ala Phe Arg Ser Lys Leu Asn Asn Ile Val Tyr Asn 
            180                 185                 190         


Arg Leu Met Phe Met Arg Ser Leu Phe Phe Phe Ala Trp Val Ser Phe 
        195                 200                 205             


Pro Ile Ile Trp Thr Leu Ala Pro Thr Gly Ile Cys Met Ile Asn Glu 
    210                 215                 220                 


Asn Ala Thr Val Leu Ala Tyr Leu Ile Ala Asp Met Leu Cys Lys Asn 
225                 230                 235                 240 


Met Tyr Gly Ile Ile Asn Ala Asn Thr Leu Phe Gln Val Leu Asn Gly 
                245                 250                 255     


Ser Trp Thr Pro Glu Thr Leu Glu Ser Ser Lys Leu Pro Gln Lys Asn 
            260                 265                 270         


Glu Val His Glu Thr Tyr Ile Asp Met Ala Leu Asp Ser Trp Arg Gly 
        275                 280                 285             


Lys Ala Ser Glu Glu Thr Glu Ala 
    290                 295     


<210>  48
<211>  885
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R2ACR_142-1

<400>  48

Ala Thr Gly Gly Cys Cys Ala Cys Cys Thr Thr Thr Ala Ala Cys Thr 
1               5                   10                  15      


Cys Cys Ala Cys Cys Thr Gly Gly Ala Cys Cys Ala Cys Cys Thr Ala 
            20                  25                  30          


Cys Gly Gly Cys Gly Cys Cys Thr Gly Gly Gly Ala Ala Gly Cys Thr 
        35                  40                  45              


Gly Cys Thr Ala Ala Cys Cys Cys Cys Gly Ala Gly Thr Gly Cys Gly 
    50                  55                  60                  


Cys Cys Gly Ala Gly Ala Ala Gly Ala Thr Gly Cys Ala Cys Ala Gly 
65                  70                  75                  80  


Gly Thr Cys Cys Thr Cys Cys Gly Ala Cys Gly Cys Thr Gly Thr Gly 
                85                  90                  95      


Cys Ala Cys Gly Thr Gly Gly Thr Gly Cys Ala Gly Cys Thr Cys Ala 
            100                 105                 110         


Cys Cys Thr Gly Gly Gly Cys Cys Ala Thr Cys Gly Thr Gly Ala Gly 
        115                 120                 125             


Cys Thr Thr Cys Cys Thr Gly Cys Ala Gly Ala Gly Cys Ala Thr Gly 
    130                 135                 140                 


Thr Thr Cys Ala Thr Gly Cys Thr Gly Thr Cys Cys Ala Gly Gly Thr 
145                 150                 155                 160 


Thr Cys Cys Cys Cys Ala Gly Gly Ala Ala Cys Gly Cys Cys Thr Gly 
                165                 170                 175     


Gly Gly Ala Gly Gly Cys Cys Gly Thr Gly Thr Thr Cys Cys Thr Gly 
            180                 185                 190         


Cys Cys Cys Cys Thr Gly Gly Cys Cys Gly Ala Gly Ala Cys Ala Thr 
        195                 200                 205             


Gly Cys Cys Thr Cys Thr Ala Thr Gly Gly Cys Cys Thr Gly Gly Cys 
    210                 215                 220                 


Cys Thr Cys Cys Ala Cys Cys Gly Gly Cys Ala Ala Cys Gly Gly Cys 
225                 230                 235                 240 


Thr Ala Cys Gly Thr Gly Ala Cys Cys Ala Thr Gly Gly Cys Cys Ala 
                245                 250                 255     


Ala Cys Gly Gly Cys Ala Gly Ala Ala Cys Ala Cys Thr Gly Cys Cys 
            260                 265                 270         


Cys Thr Gly Gly Gly Gly Cys Ala Gly Gly Ala Thr Gly Gly Cys Cys 
        275                 280                 285             


Ala Gly Cys Thr Gly Gly Cys Thr Gly Gly Cys Thr Ala Cys Cys Thr 
    290                 295                 300                 


Gly Cys Cys Cys Cys Ala Thr Thr Ala Thr Cys Ala Thr Gly Ala Ala 
305                 310                 315                 320 


Cys Cys Ala Gly Ala Thr Cys Ala Ala Cys Gly Cys Cys Gly Thr Gly 
                325                 330                 335     


Gly Cys Cys Ala Cys Cys Gly Thr Gly Ala Ala Cys Thr Thr Cys Cys 
            340                 345                 350         


Ala Cys Gly Gly Cys Ala Thr Cys Ala Gly Cys Cys Thr Gly Ala Ala 
        355                 360                 365             


Cys Cys Gly Thr Ala Thr Thr Cys Ala Ala Gly Thr Gly Thr Gly Cys 
    370                 375                 380                 


Gly Cys Cys Ala Gly Cys Ala Thr Cys Cys Thr Cys Ala Cys Cys Ala 
385                 390                 395                 400 


Thr Cys Gly Thr Gly Ala Thr Gly Gly Gly Cys Gly Thr Gly Ala Cys 
                405                 410                 415     


Cys Gly Cys Cys Thr Cys Cys Gly Thr Gly Ala Cys Cys Gly Ala Thr 
            420                 425                 430         


Gly Ala Ala Cys Cys Cys Cys Cys Cys Ala Thr Gly Cys Ala Gly Thr 
        435                 440                 445             


Gly Gly Gly Cys Thr Thr Thr Thr Thr Thr Cys Gly Gly Cys Cys Thr 
    450                 455                 460                 


Gly Gly Gly Cys Ala Cys Cys Cys Thr Gly Thr Gly Cys Cys Thr Gly 
465                 470                 475                 480 


Ala Thr Cys Gly Thr Gly Gly Ala Gly Thr Ala Cys Gly Thr Gly Ala 
                485                 490                 495     


Thr Thr Ala Cys Cys Ala Cys Cys Ala Thr Cys Ala Thr Cys Ala Thr 
            500                 505                 510         


Cys Thr Cys Cys Gly Cys Cys Gly Gly Cys Gly Thr Gly Gly Cys Cys 
        515                 520                 525             


Ala Ala Ala Thr Thr Thr Cys Ala Gly Cys Cys Cys Thr Ala Cys Gly 
    530                 535                 540                 


Thr Gly Gly Ala Gly Gly Ala Gly Ala Gly Cys Gly Ala Gly Ala Cys 
545                 550                 555                 560 


Cys Thr Gly Thr Ala Gly Gly Ala Ala Gly Gly Cys Cys Ala Thr Cys 
                565                 570                 575     


Gly Gly Cys Ala Gly Gly Cys Thr Gly Thr Ala Cys Cys Thr Gly Gly 
            580                 585                 590         


Thr Cys Ala Gly Gly Ala Ala Cys Ala Thr Gly Ala Thr Cys Thr Thr 
        595                 600                 605             


Cys Ala Gly Cys Ala Cys Cys Thr Gly Gly Gly Cys Cys Gly Cys Cys 
    610                 615                 620                 


Thr Thr Cys Cys Cys Thr Ala Thr Cys Gly Thr Gly Thr Gly Gly Cys 
625                 630                 635                 640 


Thr Gly Cys Thr Gly Thr Cys Cys Cys Cys Cys Cys Ala Ala Gly Gly 
                645                 650                 655     


Ala Gly Cys Cys Thr Gly Thr Gly Thr Gly Thr Thr Cys Gly Gly Cys 
            660                 665                 670         


Gly Ala Gly Gly Ala Cys Gly Thr Gly Gly Thr Gly Cys Cys Cys Cys 
        675                 680                 685             


Thr Gly Cys Thr Gly Thr Ala Cys Cys Thr Gly Ala Thr Cys Gly Cys 
    690                 695                 700                 


Cys Gly Ala Cys Gly Cys Cys Cys Thr Gly Thr Gly Cys Ala Ala Gly 
705                 710                 715                 720 


Ala Ala Cys Gly Thr Gly Thr Ala Cys Gly Gly Cys Cys Thr Gly Ala 
                725                 730                 735     


Thr Cys Thr Gly Gly Thr Ala Thr Ala Ala Cys Ala Cys Cys Ala Cys 
            740                 745                 750         


Cys Thr Gly Gly Gly Thr Gly Cys Thr Gly Cys Thr Gly Gly Gly Cys 
        755                 760                 765             


Gly Ala Thr Gly Gly Ala Gly Thr Gly Thr Gly Gly Gly Ala Cys Cys 
    770                 775                 780                 


Cys Thr Ala Cys Cys Ala Ala Gly Cys Ala Cys Gly Thr Gly Gly Cys 
785                 790                 795                 800 


Cys Ala Ala Gly Cys Ala Ala Gly Cys Cys Cys Cys Thr Gly Cys Cys 
                805                 810                 815     


Cys Thr Gly Cys Ala Gly Cys Ala Gly Gly Ala Gly Ala Thr Gly Ala 
            820                 825                 830         


Cys Cys Gly Cys Cys Ala Ala Cys Ala Cys Cys Thr Cys Cys Gly Thr 
        835                 840                 845             


Gly Ala Thr Thr Ala Thr Gly Gly Cys Cys Cys Cys Thr Gly Cys Cys 
    850                 855                 860                 


Gly Thr Gly Ala Thr Cys Cys Ala Gly Gly Ala Gly Ala Cys Cys Cys 
865                 870                 875                 880 


Cys Cys Thr Gly Thr 
                885 


<210>  49
<211>  295
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic rhodopsin (7 TM) domain (R2ACR_142-1)

<400>  49

Met Ala Thr Phe Asn Ser Thr Trp Thr Thr Tyr Gly Ala Trp Glu Ala 
1               5                   10                  15      


Ala Asn Pro Glu Cys Ala Glu Lys Met His Arg Ser Ser Asp Ala Val 
            20                  25                  30          


His Val Val Gln Leu Thr Trp Ala Ile Val Ser Phe Leu Gln Ser Met 
        35                  40                  45              


Phe Met Leu Ser Arg Phe Pro Arg Asn Ala Trp Glu Ala Val Phe Leu 
    50                  55                  60                  


Pro Leu Ala Glu Thr Cys Leu Tyr Gly Leu Ala Ser Thr Gly Asn Gly 
65                  70                  75                  80  


Tyr Val Thr Met Ala Asn Gly Arg Thr Leu Pro Trp Gly Arg Met Ala 
                85                  90                  95      


Ser Trp Leu Ala Thr Cys Pro Ile Ile Met Asn Gln Ile Asn Ala Val 
            100                 105                 110         


Ala Thr Val Asn Phe His Gly Ile Ser Leu Asn Arg Ile Gln Val Cys 
        115                 120                 125             


Ala Ser Ile Leu Thr Ile Val Met Gly Val Thr Ala Ser Val Thr Asp 
    130                 135                 140                 


Glu Pro Pro Met Gln Trp Ala Phe Phe Gly Leu Gly Thr Leu Cys Leu 
145                 150                 155                 160 


Ile Val Glu Tyr Val Ile Thr Thr Ile Ile Ile Ser Ala Gly Val Ala 
                165                 170                 175     


Lys Phe Gln Pro Tyr Val Glu Glu Ser Glu Thr Cys Arg Lys Ala Ile 
            180                 185                 190         


Gly Arg Leu Tyr Leu Val Arg Asn Met Ile Phe Ser Thr Trp Ala Ala 
        195                 200                 205             


Phe Pro Ile Val Trp Leu Leu Ser Pro Gln Gly Ala Cys Val Phe Gly 
    210                 215                 220                 


Glu Asp Val Val Pro Leu Leu Tyr Leu Ile Ala Asp Ala Leu Cys Lys 
225                 230                 235                 240 


Asn Val Tyr Gly Leu Ile Trp Tyr Asn Thr Thr Trp Val Leu Leu Gly 
                245                 250                 255     


Asp Gly Val Trp Asp Pro Thr Lys His Val Ala Lys Gln Ala Pro Ala 
            260                 265                 270         


Leu Gln Gln Glu Met Thr Ala Asn Thr Ser Val Ile Met Ala Pro Ala 
        275                 280                 285             


Val Ile Gln Glu Thr Pro Cys 
    290                 295 


<210>  50
<211>  915
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct (PsuACR_003-1)

<400>  50
atggaagccg gagccaccat cgagcaaggc ggcctggagt cctacgacca caagatcacc       60

tacggcgtct gggaaatgca gcaccccgag tgctttgaga ggggcatcga gagcggcgac      120

gccgtgaaga tcctgcagct gtgcttcgcc gtgatctcca tctgccaggt gatcttcatg      180

ttcaccaggg cccccaaggt ggcttgggag tccatctacc tgcccctggc tgagtgcatc      240

acatacttcc tggccttcac cggctacgga gtgctgagga tgagcgacgg cagaatcttc      300

ccctgggcca ggatggccag ctgggtgtgc acatgccctg tgatgctggg ccaggtgagc      360

gccatgggcc tgatcaagtg gaagagcgtg cccctgaaca atgtgatgat cgccgccagc      420

ctggtgaggg tgtgcatggg catcaccgcc accgtgaccc ccaatgacaa cctgaagtgg      480

atgttcttct tcttcggcgt gacctgtctg ctcttcgagt acacctgcgt cttcaccatc      540

ttccagctga ccatcaacga cttcgaggag atcggctccc ccctgggcaa tttcgtggcc      600

ggaagggccc gtattttaag gatcatcttc cacaccgcct ggacctgctt ccctgtgctg      660

tgggtgctga gctccaccgg cacctgcatg ctggatgaaa acacctccgc cacactgttc      720

atgctggccg acgccgcctg caagaacatg tacggcctca tcctgtggaa caccacctgg      780

ggccatctga acggcaagtg ggacagggat tacgtgagga gccagatcga ggccaaggaa      840

gagaagcctg ccgacaagga gatgtcccag gtgcctcccg ccgctcagga tgatggcgtg      900

aaggtcttcg gcagg                                                       915


<210>  51
<211>  888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R2ACR_853-2

<400>  51
atgagcgccg tggccgatcc ccagttcggc ctgtacggca cctgggaggc cagcaacatg       60

gattgcgccg ccatgggccc caccatcacc agcaccacca agatcttcca gctgctgttc      120

gcctgcatct gcgcctgcca ggtggtgttc atggccagca gagcccccag agtgacctgg      180

gaggccgtgt acctgcccct ggtggagacc atcctgtaca gcgtggccgc caccggcaac      240

ggcaacatga gactgagcga cggcagagtg gtgcccatcg ccagattctg cagctggctg      300

atcacctgcc ccatcatgct gttccaggtg gtgggcatcc acgagctgaa gtggatgggc      360

gtgagctgca agaacatggt gatggccgcc accctgatcc agaccgtgta cggcatcggc      420

gccagcgtga tcagcaacaa cttcatgaag tggttcctgt tcttcctggg ctgcatctgc      480

ctggccttcg acttcttcct ggtgagcagc atcttcgccg ccggcctgaa gaagttcggc      540

gccttcagaa gcaagctgaa caacatcgtg tacaacagac tgatgttcat gagaagcctg      600

ttcttcttcg cctgggtgag cttccccatc atctggaccc tggcccccac cggcatctgc      660

atgatcaacg agaacgccac cgtgctggcc tacctgatcg ccgatatgct gtgcaagaac      720

atgtacggca tcatcaacgc caacaccctg ttccaggtgc tgaacggcag ctggaccccc      780

gagaccctgg agagcagcaa gctgccccag aagaacgagg tgcacgagac ctacatcgat      840

atggccctgg atagctggag aggcaaggcc agcgaggaga ccgaggcc                   888


<210>  52
<211>  885
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R2ACR_142-2

<400>  52
atggccacct ttaactccac ctggaccacc tacggcgcct gggaagctgc taaccccgag       60

tgcgccgaga agatgcacag gtcctccgac gctgtgcacg tggtgcagct cacctgggcc      120

atcgtgagct tcctgcagag catgttcatg ctgtccaggt tccccaggaa cgcctgggag      180

gccgtgttcc tgcccctggc cgagacatgc ctctatggcc tggcctccac cggcaacggc      240

tacgtgacca tggccaacgg cagaacactg ccctggggca ggatggccag ctggctggct      300

acctgcccca ttatcatgaa ccagatcaac gccgtggcca ccgtgaactt ccacggcatc      360

agcctgaacc gtattcaagt gtgcgccagc atcctcacca tcgtgatggg cgtgaccgcc      420

tccgtgaccg atgaaccccc catgcagtgg gcttttttcg gcctgggcac cctgtgcctg      480

atcgtggagt acgtgattac caccatcatc atctccgccg gcgtggccaa atttcagccc      540

tacgtggagg agagcgagac ctgtaggaag gccatcggca ggctgtacct ggtcaggaac      600

atgatcttca gcacctgggc cgccttccct atcgtgtggc tgctgtcccc ccaaggagcc      660

tgtgtgttcg gcgaggacgt ggtgcccctg ctgtacctga tcgccgacgc cctgtgcaag      720

aacgtgtacg gcctgatctg gtataacacc acctgggtgc tgctgggcga tggagtgtgg      780

gaccctacca agcacgtggc caagcaagcc cctgccctgc agcaggagat gaccgccaac      840

acctccgtga ttatggcccc tgccgtgatc caggagaccc cctgt                      885


<210>  53
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized construct R2ACR_041-1

<400>  53
atgggcctga ccgtgacatc taacacaaag gtgttccagc tgctgtttgc ctgcgtgtgc       60

gcctgccagg tgctgttcat ggcaagcagg gcaccaagag tgacatggga ggccgtgtac      120

ctgcccctgg tggagacaat cctgtatgcc atggccgcca gcggcaatgg ctccatgagg      180

ctggcagacg gacgcgtgat ccctatcggc cggttctgtt cctggctgat cacatgccca      240

atcatgctgt ttcaggtggt gggcatccac gagctgaagt ggtctggcgt gagctgtaag      300

aacatggtca tggccgccag cctgatcaga accgtgtacg gaatcggagc atccgtggtg      360

gccaatgaca tcatgaagtg ggtgctgtat gtgctgggct gcgtgtgcct ggccttcgag      420

tttctggtgg tgcactccat cttttctgcc ggcctgaaga agttcgccgc ctttaggtct      480

accctgaacg atggcgtgta caatcggctg ctgttcatga gagccctgtt ctttaccgcc      540

tggacatctt ttccagtgat ctgggtgctg gccagcacag gcatctgtct gatcgacgag      600

aacgtgaccg tgctggccta cctgatcgcc gatatgctgt gcaagaatat gtatggcatc      660

atcaacgcca atacactgtt ccgggtgctg gacggctcct ggaccccaga gacactggag      720

acaagcaaga acccccctaa gcacgaggtg cacgagacat atatcgatat ggccatgcac      780

cacatgaggc ccagcaagtc caagacaagg gaggcagcaa tcgagctgga ggagcacacc      840

gccgatcctt ttgccgaggg c                                                861


<210>  54
<211>  888
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized R2ACR1

<400>  54
atgagcgccg tggccgaccc ccagttcggc ctgtacggca cctgggaggc cagcaacatg       60

gactgcgccg ccatgggccc caccatcacc agcaccacca agatcttcca gctgctgttc      120

gcctgcatct gcgcctgcca ggtggtgttc atggccagcc gcgccccccg cgtgacctgg      180

gaggccgtgt acctgcccct ggtggagacc atcctgtaca gcgtggccgc caccggcaac      240

ggcaacatgc gcctgagcga cggccgcgtg gtgcccatcg cccgcttctg cagctggctg      300

atcacctgcc ccatcatgct gttccaggtg gtgggcatcc acgagctgaa gtggatgggc      360

gtgagctgca agaacatggt gatggccgcc accctgatcc agaccgtgta cggcatcggc      420

gccagcgtga tcagcaacaa cttcatgaag tggttcctgt tcttcctggg ctgcatctgc      480

ctggccttcg acttcttcct ggtgagcagc atcttcgccg ccggcctgaa gaagttcggc      540

gccttccgca gcaagctgaa caacatcgtg tacaaccgcc tgatgttcat gcgcagcctg      600

ttcttcttcg cctgggtgag cttccccatc atctggaccc tggcccccac cggcatctgc      660

atgatcaacg agaacgccac cgtgctggcc tacctgatcg ccgacatgct gtgcaagaac      720

atgtacggca tcatcaacgc caacaccctg ttccaggtgc tgaacggcag ctggaccccc      780

gagaccctgg agagcagcaa gctgccccag aagaacgagg tgcacgagac ctacatcgac      840

atggccctgg acagctggcg cggcaaggcc agcgaggaga ccgaggcc                   888


<210>  55
<211>  885
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cDNA synthetic humanized R2ACR2

<400>  55
atggccacct tcaacagcac ctggaccacc tacggcgcct gggaggccgc caaccccgag       60

tgcgccgaga agatgcaccg cagcagcgac gccgtgcacg tggtgcagct gacctgggcc      120

atcgtgagct tcctgcagag catgttcatg ctgagccgct tcccccgcaa cgcctgggag      180

gccgtgttcc tgcccctggc cgagacctgc ctgtacggcc tggccagcac cggcaacggc      240

tacgtgacca tggccaacgg ccgcaccctg ccctggggcc gcatggccag ctggctggcc      300

acctgcccca tcatcatgaa ccagatcaac gccgtggcca ccgtgaactt ccacggcatc      360

agcctgaacc gcatccaggt gtgcgccagc atcctgacca tcgtgatggg cgtgaccgcc      420

agcgtgaccg acgagccccc catgcagtgg gccttcttcg gcctgggcac cctgtgcctg      480

atcgtggagt acgtgatcac caccatcatc atcagcgccg gcgtggccaa gttccagccc      540

tacgtggagg agagcgagac ctgccgcaag gccatcggcc gcctgtacct ggtgcgcaac      600

atgatcttca gcacctgggc cgccttcccc atcgtgtggc tgctgagccc ccagggcgcc      660

tgcgtgttcg gcgaggacgt ggtgcccctg ctgtacctga tcgccgacgc cctgtgcaag      720

aacgtgtacg gcctgatctg gtacaacacc acctgggtgc tgctgggcga cggcgtgtgg      780

gaccccacca agcacgtggc caagcaggcc cccgccctgc agcaggagat gaccgccaac      840

accagcgtga tcatggcccc cgccgtgatc caggagaccc cctgc                      885


<210>  56
<211>  288
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (GcACR_201)

<400>  56

Met Glu Ala Ala Asp Glu Glu Asp Val Gly Gly Gly Asp Leu Trp Asn 
1               5                   10                  15      


Val Asn Thr Gly Cys Leu Tyr Gly Asn Leu Ala Ser Ala Ser Pro Leu 
            20                  25                  30          


Val Arg His Phe Glu Leu Ala Trp Ala Val Cys Cys Leu Thr Gln Ala 
        35                  40                  45              


Phe Phe Lys Phe Thr Gln Trp Pro Arg Ala Ala Trp Glu Gly Val Tyr 
    50                  55                  60                  


Ile Pro Leu Cys Glu Thr Val Gln Tyr Ser Leu Leu Phe Phe Lys Leu 
65                  70                  75                  80  


Gly Tyr Ile Gln Val Gly Val Asn Gln Gly Ala Tyr Leu Pro Trp Val 
                85                  90                  95      


Arg Tyr Ser Phe Trp Met Ile Thr Thr Pro Val Leu Leu Asn Gln Ile 
            100                 105                 110         


Gln Gln Ile Cys Glu Val Lys Ile Trp Gly Ala Arg Met Gly Pro Val 
        115                 120                 125             


Gln Thr Trp Ala Asn Ile Ala Met Val Thr Leu Gly Ile Ser Gly Ala 
    130                 135                 140                 


Leu Ile Gln Asn Pro Thr Met Lys Trp Leu Cys Phe Val Ala Gly Thr 
145                 150                 155                 160 


Leu Leu Gly Ala Leu Ile Phe Leu Val Ala Phe Leu Ile Phe His Lys 
                165                 170                 175     


Ala Ser Glu Gln Phe Lys Glu Ile Gly His Pro Lys Ala Asp Arg Val 
            180                 185                 190         


Val Lys Tyr Leu Trp Tyr Leu Gln Val Cys Phe Phe Ser Ser Trp Ser 
        195                 200                 205             


Val Phe Pro Leu Leu Trp Ile Ile Ser Ala Gln Gly Thr Cys Ile Ala 
    210                 215                 220                 


Asn Glu Asp Ile Val Ser Ser Ile His Ile Pro Ala Asp Ile Leu Ala 
225                 230                 235                 240 


Lys Asn Val Phe Gly Leu Ile Ile Trp His Ile Arg Phe His Leu Cys 
                245                 250                 255     


Asp Gly Tyr Trp Asp Ile Glu Arg Phe Lys Gln Lys Leu Leu Gln Asp 
            260                 265                 270         


Lys Leu Leu Ala Leu Phe Asp Asn Pro Glu Glu Leu Arg Gln Asp His 
        275                 280                 285             


<210>  57
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (HpACR_213)

<400>  57

Met Thr Val Ile Tyr Gly Gln Trp Ala Ala Gln Asn Pro Gly Cys Val 
1               5                   10                  15      


Ser Met Thr Asn Ile Asp Leu Gly Val Arg Thr Phe Glu Leu Cys Trp 
            20                  25                  30          


Gly Ile Met Cys Ala Cys Gln Ala Val Phe Phe Ala Leu Arg Tyr Pro 
        35                  40                  45              


Arg Ala Thr Trp Glu Phe Val Met Val Pro Leu Thr Glu Cys Phe Ile 
    50                  55                  60                  


Tyr Gly Leu Gly Tyr Ser Glu Ile Gly Tyr Ile Leu Leu Trp Asp Gly 
65                  70                  75                  80  


Arg Gln Val Leu Trp Thr Arg Thr Val Leu Trp Leu Ala Thr Val Pro 
                85                  90                  95      


Ile Leu Leu Asn Gln Ile Asn Ala Met Ala Ala Val His Ile Tyr Gly 
            100                 105                 110         


Val Asp Leu Asn Ile Met Gln Met Tyr Phe Ser Thr Leu Met Ile Cys 
        115                 120                 125             


Leu Gly His Thr Ala Ala Leu Thr His Asn Gln Ser Leu Lys Trp Leu 
    130                 135                 140                 


Phe Phe Ile Met Ala Met Ala Ile Phe Gly Val Ile Cys Phe Ile Asn 
145                 150                 155                 160 


Tyr Tyr Thr Phe Ala Ala Ala Glu Lys His Tyr Lys Glu Ser Gly Ser 
                165                 170                 175     


Glu Asn Asp Leu Lys Ile Ala Lys Arg Ile Arg Leu Leu Ala Ile Ile 
            180                 185                 190         


Phe Phe Thr Ser Trp Thr Met Tyr Pro Leu Phe Phe Val Leu Ser Val 
        195                 200                 205             


Glu Gly Ala Cys Val Ala Ser Glu Ser Val Ile Leu Val Cys Phe Ala 
    210                 215                 220                 


Leu Ala Asp Leu Leu Ser Lys Asn Val Phe Gly Val Leu Phe Trp Asp 
225                 230                 235                 240 


Thr Leu Trp Asn Met Gln Asp Gly Lys Trp Thr Ser Tyr Gly Thr Val 
                245                 250                 255     


Thr Phe Phe Lys Thr Thr Asp Ser Val Thr Lys Thr Ala Ile Ser Thr 
            260                 265                 270         


Ala Met Glu Glu Glu Tyr Ser Lys Gln Lys Val Ser Arg 
        275                 280                 285 


<210>  58
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (HaACR_359)

<400>  58

Met Ala Thr Pro Ala Pro Ala Gly Ala Pro Leu Thr Thr Thr Pro Val 
1               5                   10                  15      


Pro Tyr Gly Gln Trp Glu Ala Asn Asn Pro Ala Cys Val Ala Leu Phe 
            20                  25                  30          


Thr Met Pro Ala Gln Val Gln Thr Leu Met Leu Cys Trp Cys Ile Ile 
        35                  40                  45              


Cys Ser Cys Gln Ala Ile Phe Leu Met Ser Arg Trp Pro Arg Val Gly 
    50                  55                  60                  


Trp Glu Leu Val Ala Ala Pro Ala Ile Glu Ser Ile Val Tyr Gly Leu 
65                  70                  75                  80  


Gly Tyr Gln Gly Ile Gly Tyr Val Lys Met Ala Ser Gly Gln Pro Leu 
                85                  90                  95      


Ala Tyr Ala Arg Phe Phe Met Met Ile Thr Ile Thr Pro Met Ile Leu 
            100                 105                 110         


Leu Asp Ile Asn Lys Leu Ala Ser Val Arg Leu Leu Gly Leu Asn Met 
        115                 120                 125             


Asn Ser Met Gln Leu Gly Ala Asn Val Leu Leu Trp Met Phe Trp Gln 
    130                 135                 140                 


Ala Ser Thr Met Ser Thr Leu Val Gly Leu Lys Trp Val Phe Phe Val 
145                 150                 155                 160 


Leu Gly Leu Leu Cys Leu Gly Leu Val Leu Gly Thr Ser Phe Met Ile 
                165                 170                 175     


Phe Ala Ala Ala Arg Gln Ser Phe Leu Leu Lys Gly Thr Gly Ala Gly 
            180                 185                 190         


Asp Trp Val Ala Gln Arg Ile Thr Tyr Leu Gln Met Ala Phe Leu Pro 
        195                 200                 205             


Thr Trp Thr Ala Tyr Met Val Leu Phe Val Leu Ser Gly Glu Gly Ala 
    210                 215                 220                 


Cys Ile Ala Gly Glu Gly Val Ile Leu Pro Ile Ala Ile Val Met Asp 
225                 230                 235                 240 


Leu Phe Gln Lys Asn Val His Gly Leu Ile Ile Trp Ser Thr Phe Trp 
                245                 250                 255     


Asn Phe Leu Gly Gly Ser Trp Asn Pro Glu Arg Leu Ala Glu Glu Arg 
            260                 265                 270         


Ala Pro Ser Arg Ile Ala Gly Leu Lys Val Ile Glu Asn Asn Ala His 
        275                 280                 285             


Pro Val Asp 
    290     


<210>  59
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (HrACR_495)

<400>  59

Met Ala Thr Pro Gly Pro Ala Ala Val Pro Ser Met Thr Thr Thr Pro 
1               5                   10                  15      


Ala Pro Tyr Gly Thr Trp Glu Ala Asn Asn Pro Ser Cys Val Ala Leu 
            20                  25                  30          


Phe Asn Ser Ser Pro Gln Ile Gln Thr Leu Met Leu Cys Trp Cys Ile 
        35                  40                  45              


Ile Cys Thr Cys Gln Ser Ile Phe Leu Met Ser Arg Trp Pro Arg Val 
    50                  55                  60                  


Gly Trp Glu Leu Val Ala Ala Pro Ala Val Glu Cys Ile Val Tyr Gly 
65                  70                  75                  80  


Leu Gly Tyr Gln Gly Ile Gly Tyr Val Lys Met Ala Ser Gly Gln Gln 
                85                  90                  95      


Leu Ala Tyr Ala Arg Phe Phe Met Met Ile Thr Val Thr Leu Met Ile 
            100                 105                 110         


Leu Ile Asp Val Asn Lys Leu Ala Ser Val Arg Leu Leu Gly Leu Asn 
        115                 120                 125             


Met Asn Ser Met Gln Leu Ala Ala Asn Leu Leu Leu Trp Met Phe Trp 
    130                 135                 140                 


Gln Ala Ser Thr Met Ser Thr Leu Ser Gly Leu Lys Trp Val Leu Phe 
145                 150                 155                 160 


Val Leu Gly Leu Ile Cys Leu Gly Ile Val Leu Gly Thr Ser Phe Met 
                165                 170                 175     


Ile Phe Ser Ala Ala Arg Gln Gly Phe Leu Asp Lys Asn Thr Gly Ala 
            180                 185                 190         


Gly Asp Trp Val Ala Gln Arg Ile Val Phe Leu Glu Val Val Phe Phe 
        195                 200                 205             


Pro Thr Trp Ala Gly Tyr Met Val Leu Tyr Val Ile Ser Gly Glu Gly 
    210                 215                 220                 


Ala Cys Ile Ala Pro Glu Thr Val Ile Ile Pro Val Ala Ile Val Leu 
225                 230                 235                 240 


Asp Leu Phe Gln Lys Asn Val His Gly Leu Ile Ile Trp Ser Thr Phe 
                245                 250                 255     


Trp Asn Phe Leu Gly Gly Ser Trp Asn Pro Gly Arg Leu Ala Glu Glu 
            260                 265                 270         


Arg Ala Pro Ser Arg Leu Ala Gly Leu Lys Val Ile Glu Asn Thr Ala 
        275                 280                 285             


His Gly Phe Asp Asp Glu Ala Leu Ser Glu Gly Phe 
    290                 295                 300 


<210>  60
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (PsuACR_353)

<400>  60

Met Glu Val Glu Met Glu Met Glu Met Glu Gly Leu Gly Asn Ser Thr 
1               5                   10                  15      


Ser Met Phe Glu Glu Val Val Gly Cys Asp Leu Gly Ala Ser Pro Val 
            20                  25                  30          


Gly Glu Thr Glu Met His Val Val Gln Trp Ile Gly Ser Phe Ile Cys 
        35                  40                  45              


Ile Phe Gln Cys Leu Trp Phe Leu Ser Lys Trp Pro Asn Phe Thr Trp 
    50                  55                  60                  


Asp Thr Pro Tyr Ile Pro Ala Val Glu Ala Val Gly Tyr Gly Leu Met 
65                  70                  75                  80  


Ala Asn Gly Phe Gly Tyr Ala Glu Leu Phe Glu Gly Glu Arg His Val 
                85                  90                  95      


Pro Trp Leu Arg Tyr Ser Ile Trp Val Leu Ser Thr Pro Val Leu Leu 
            100                 105                 110         


Trp Asp Ile Gln Asp Ile Leu Asp Ala Phe Tyr Arg Gly Thr Arg Leu 
        115                 120                 125             


Ala Pro Val Gln Ser Leu Ala Asn Leu Phe Leu Leu Cys Phe Gly Phe 
    130                 135                 140                 


Ile Gly Ala Ile Glu His Val Leu Ala Val Lys Tyr Leu Cys Tyr Ser 
145                 150                 155                 160 


Ile Gly Val Met Met Leu Gly Val Val Phe Phe Cys Ala Tyr Asn Ile 
                165                 170                 175     


Val Gly Gln Ala Val Ala Asn Phe Glu Ala Thr Asp Thr Ala Gln Gly 
            180                 185                 190         


Arg Leu Val Ala Phe Arg Leu Lys Leu Ile Ala Cys Ile Phe Met Thr 
        195                 200                 205             


Ser Phe Ser Gly Tyr Pro Ile Leu Trp Ile Leu Ser Asn Gln Gly Leu 
    210                 215                 220                 


Cys Leu Val Pro Glu Met Ile Ile Glu Val Val His Ile Pro Leu Asp 
225                 230                 235                 240 


Leu Ile Ala Lys Asn Leu Phe Thr Leu Leu Thr Trp His Thr His Tyr 
                245                 250                 255     


Ile Leu Leu Asn Gly Asp Trp Ser Cys Glu Ala Met Val Ala Arg Leu 
            260                 265                 270         


Gln Glu Gln Asn Asp Ile Glu Met Ala Gln Gln Pro Arg Glu Ala Gly 
        275                 280                 285             


Gln Leu Arg Lys Asp Leu Met Gln Lys Ala Gln Gly 
    290                 295                 300 


<210>  61
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (RaACR_687)

<400>  61

Met Gly Asp Met Ser His Ile Glu Thr Val Tyr Tyr Val Asn Gly Thr 
1               5                   10                  15      


Glu Val Asp Pro Trp Thr His Arg Cys Gln Leu Gly Val Pro Gly Gly 
            20                  25                  30          


Ser Gln Gly Ile His Thr Phe Gln Leu Thr Trp Ser Leu Ile Cys Thr 
        35                  40                  45              


Ala Gln Ala Ile Phe Leu Met Thr Lys Trp Pro Lys Val Gly Trp Glu 
    50                  55                  60                  


Ala Ile Tyr Met Pro Cys Cys Glu Ala Leu Ser Tyr Gly Leu Leu Ser 
65                  70                  75                  80  


Ala Gly His Gly Tyr Leu Lys Leu His Gly Glu Trp His Tyr Ile Pro 
                85                  90                  95      


Trp Ile Arg Tyr Ala Ala Trp Met Val Thr Thr Pro Val Leu Leu Asn 
            100                 105                 110         


Gln Val Gln Gly Val Leu Asp Val Lys Val Gly His Leu Arg Leu Ala 
        115                 120                 125             


Pro Ile Gln Ser Leu Ala Asn Leu Ile Met Ile Val Met Gly Val Ser 
    130                 135                 140                 


Ala His Leu Gln Glu Asn Ile Ala Trp Lys Trp Val Phe Phe Leu Ile 
145                 150                 155                 160 


Gly Cys Val Met Ala Leu Val Ile Tyr Trp Val Ala Trp Leu Val Phe 
                165                 170                 175     


Ser Thr Gln Ile Lys Tyr Tyr Ala Glu Thr Lys Thr Ala Val Gly Asp 
            180                 185                 190         


Arg Val Val Phe Gln Leu Lys Leu Ile Ala Val Ala Phe Tyr Val Gly 
        195                 200                 205             


Trp Ser Ala Phe Pro Leu Ile Trp Met Leu Ser Ser Glu Gly Leu Cys 
    210                 215                 220                 


Ala Ile Glu Glu His Ile Ala Ala Ala Ala His Ile Pro Ala Asp Val 
225                 230                 235                 240 


Leu Ser Lys Asn Ile Phe Gly Leu Leu Met Trp His Thr Arg Trp Ile 
                245                 250                 255     


Val Leu Gly Gly Tyr Trp Asp Val Asn Lys Phe Lys Glu Thr Ile Ala 
            260                 265                 270         


Gln Gln Lys Leu Glu Glu Ala Lys Gly Glu Glu Thr Pro Gln Glu Lys 
        275                 280                 285             


Arg Lys Ala Leu Met Gly Gln Ala Glu Ala Cys Phe Lys Met Ala Asp 
    290                 295                 300                 


Ala Cys 
305     


<210>  62
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (RlACR_497)

<400>  62

Met Glu Tyr Gln Ser Leu Asp Asp Phe Pro Leu Glu Thr Leu Tyr Phe 
1               5                   10                  15      


Arg Asn Gly Thr Glu Val Asp Pro Tyr Asp His Arg Cys Lys Leu Gly 
            20                  25                  30          


Ile Pro Gly Gly Ser Gln Gly Ile His Thr Phe Gln Leu Val Trp Ala 
        35                  40                  45              


Leu Leu Cys Ala Ala Gln Ala Leu Phe Leu Phe Ser Lys Trp Pro Lys 
    50                  55                  60                  


Val Gly Trp Glu Ala Met Tyr Met Pro Cys Cys Glu Ala Leu Ser Tyr 
65                  70                  75                  80  


Gly Leu Leu Ser Ser Gly Tyr Gly Tyr Met Lys Leu His Gly Glu Phe 
                85                  90                  95      


His Tyr Leu Pro Trp Ile Arg Tyr Ala Ala Trp Ile Val Thr Thr Pro 
            100                 105                 110         


Val Leu Leu Asn Gln Val Gln Gly Met Ile Asp Ile Lys Ile Gly Ser 
        115                 120                 125             


Leu Arg Leu Ala Pro Ile Gln Ser Leu Ala Asn Leu Ile Met Ile Ile 
    130                 135                 140                 


Met Gly Val Ser Ala His Leu Gln Glu Asn His Ala Trp Lys Trp Leu 
145                 150                 155                 160 


Phe Phe Phe Val Gly Cys Val Met Cys Ala Val Ile Tyr Tyr Ile Ala 
                165                 170                 175     


Trp Leu Gln Phe Ala Lys Val Asn Glu Leu Tyr Ala Ala Thr Lys Thr 
            180                 185                 190         


Glu Ile Gly Asp Lys Val Cys Phe Gln Leu Lys Leu Ile Met Phe Cys 
        195                 200                 205             


Phe Tyr Val Gly Trp Ser Met Phe Ser Val Ile Trp Leu Leu Ser Ser 
    210                 215                 220                 


Glu Gly Leu Cys Leu Ile Glu Glu His Ile Ser Ala Ala Ala His Ile 
225                 230                 235                 240 


Pro Gly Asp Ile Leu Ser Lys Asn Ser Phe Gly Leu Leu Met Trp Tyr 
                245                 250                 255     


Thr Arg Trp Ile Thr Leu Gly Gly Ala Trp Asp Ile Asn Lys Phe Leu 
            260                 265                 270         


Glu Lys Gln Ala Lys Glu Lys Ala Glu Ala Val Leu Thr Pro Ala Glu 
        275                 280                 285             


Lys Arg Lys Ala Ile Met Lys Gln Ala Glu Ala Cys Phe Ser Met Ala 
    290                 295                 300                 


Asp Ala Cys Leu Gln Gln Ala Asn 
305                 310         


<210>  63
<211>  307
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (RsACR_665)

<400>  63

Met Asp Tyr Thr Ser Leu Asp Asp Phe Pro Leu Glu Thr Leu Tyr Phe 
1               5                   10                  15      


Arg Asn Gly Thr Glu Val Asp Pro Tyr Asp His Arg Cys Lys Leu Gly 
            20                  25                  30          


Ile Pro Gly Gly Ser Gln Gly Ile His Thr Phe Gln Leu Val Trp Ala 
        35                  40                  45              


Leu Leu Cys Ala Ala Gln Ala Leu Phe Leu Phe Ser Lys Trp Pro Lys 
    50                  55                  60                  


Val Gly Trp Glu Ala Met Tyr Met Pro Cys Cys Glu Ala Leu Ser Tyr 
65                  70                  75                  80  


Gly Leu Leu Ser Ser Gly Tyr Gly Tyr Met Lys Leu His Gly Glu Phe 
                85                  90                  95      


His Tyr Leu Pro Trp Ile Arg Tyr Ala Ala Trp Leu Val Thr Thr Pro 
            100                 105                 110         


Val Leu Leu Asn Gln Val Gln Gly Met Ile Asp Ile Lys Ile Gly Ser 
        115                 120                 125             


Leu Arg Leu Ala Pro Ile Gln Ser Leu Ala Asn Leu Ile Met Ile Ile 
    130                 135                 140                 


Met Gly Val Ser Ala His Leu Gln Glu Asn His Ala Trp Lys Trp Leu 
145                 150                 155                 160 


Phe Phe Phe Val Gly Cys Val Met Cys Ala Val Ile Tyr Tyr Ile Ala 
                165                 170                 175     


Trp Leu Gln Phe Ala Lys Val Asn Glu Leu Tyr Ala Ala Thr Lys Thr 
            180                 185                 190         


Glu Ile Gly Asp Lys Val Cys Phe Gln Leu Lys Leu Ile Met Phe Cys 
        195                 200                 205             


Phe Tyr Val Gly Trp Ser Met Phe Ser Val Ile Trp Leu Leu Ser Ser 
    210                 215                 220                 


Glu Gly Leu Cys Leu Ile Glu Glu His Ile Ser Ala Ala Ala His Ile 
225                 230                 235                 240 


Pro Gly Asp Ile Leu Ser Lys Asn Ser Phe Gly Leu Leu Met Trp Tyr 
                245                 250                 255     


Thr Arg Trp Ile Thr Leu Gly Gly Ala Trp Asp Ile Asn Lys Phe Leu 
            260                 265                 270         


Glu Lys Gln Ala Lys Glu Lys Ala Glu Ala Val Leu Thr Pro Ala Glu 
        275                 280                 285             


Lys Arg Lys Ala Ile Met Lys Gln Ala Glu Ala Cys Phe Ser Met Ala 
    290                 295                 300                 


Asp Ala Cys 
305         


<210>  64
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (R1ACR_653)

<400>  64

Met Pro Tyr Asp Asn Tyr Gly Trp Trp Glu Arg Glu Asn Ala Asp Cys 
1               5                   10                  15      


Ile Ser Lys Met Asp Ala Lys Leu Asp Gln Met His Leu Val Gln Leu 
            20                  25                  30          


Ala Met Ser Met Leu Cys Phe Cys Gln Leu Val Phe Met Thr Ser Arg 
        35                  40                  45              


Phe Pro Lys Gln Ala Trp Glu Ala Ile Tyr Leu Pro Ala Ala Glu Cys 
    50                  55                  60                  


Val Leu Tyr Ala Met Ala Ala Ser Gly Asn Gly Tyr Leu Arg Leu Ala 
65                  70                  75                  80  


Asn Gly Arg Leu Leu Pro Trp Ala Arg Met Ala Ser Trp Leu Ala Thr 
                85                  90                  95      


Cys Pro Val Met Leu Asn Gln Ile Asn Thr Ile Ser Pro Leu Lys Leu 
            100                 105                 110         


Tyr Gly Ile Asn Leu Asn Asn Val Gln Ile Ala Leu Ser Val Val Arg 
        115                 120                 125             


Val Val Asn Gly Val Ser Ala Ser Ser Val Asp Asp Asp Ser Leu Lys 
    130                 135                 140                 


Trp Gly Phe Phe Phe Met Gly Val Phe Cys Leu Val Ile Glu Phe Ser 
145                 150                 155                 160 


Ile Ala Tyr Asn Ile Phe Ala Leu Gly Met Ala Lys Phe Lys Glu Ala 
                165                 170                 175     


Gly Lys Asp Ser Asp Ile Cys Ala Arg Ala Cys Asp Arg Leu Gln Val 
            180                 185                 190         


Leu Arg Gly Ile Phe Phe Ser Ala Trp Ala Met Phe Pro Ile Ile Trp 
        195                 200                 205             


Leu Phe Ser Pro Gln Gly Thr Cys Leu Leu Gly Glu Asp Val Ile Pro 
    210                 215                 220                 


Leu Leu Tyr Leu Phe Ala Asp Leu Val Cys Lys Asn Cys Phe Gly Ile 
225                 230                 235                 240 


Leu Trp Tyr Asp Thr Thr Trp Arg Leu Leu Asp Gly Lys Gly Trp Asn 
                245                 250                 255     


Pro Glu Leu Gln Leu Thr Asp Asn Glu Val Glu Glu Leu Val His Ala 
            260                 265                 270         


Lys Glu Glu Val Glu Asp His His His Pro His Asp Ala 
        275                 280                 285 


<210>  65
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (R1ACR_6367)

<400>  65

Met Ser Ala Ile Thr Asp Pro Ala Leu Gly Leu Tyr Gly Thr Trp Glu 
1               5                   10                  15      


Ala Ala Asn Lys Glu Cys Val Asp Lys Gly Val Glu Phe Ser Ser Asn 
            20                  25                  30          


Thr Arg Met Ile Val Leu Leu Phe Ala Ser Val Cys Phe Cys Gln Thr 
        35                  40                  45              


Val Tyr Met Thr Ser Arg Ala Pro Arg Val Asn Trp Glu Gly Cys Tyr 
    50                  55                  60                  


Leu Pro Leu Cys Glu Thr Phe Leu Tyr Gly Leu Ala Ala Ser Gly Asn 
65                  70                  75                  80  


Gly Met Ile Arg Leu Ser Asn Gly Arg Met Val Pro Met Ala Arg Phe 
                85                  90                  95      


Cys Ser Trp Leu Val Thr Cys Pro Ile Met Leu Met Ser Val Leu Ala 
            100                 105                 110         


Ile His Asp Val Arg Trp Met Gly Val Pro Val Lys Asn Met Val Ile 
        115                 120                 125             


Ala Ala Thr Leu Ile Arg Thr Val Leu Gly Ile Gly Ala Ser Ser Thr 
    130                 135                 140                 


Ile Thr Glu Thr Leu Arg Trp Val Gln Tyr Cys Ile Ala Cys Ala Val 
145                 150                 155                 160 


Phe Val Phe Glu Leu Thr Met Val Asn Gln Leu Phe Ile Ala Gly Leu 
                165                 170                 175     


Gln Lys Phe Gly Val Val Lys Thr Lys Leu Asn Asp Met Val Tyr Met 
            180                 185                 190         


Arg Ile Met Ile Leu Arg Ala Leu Phe Phe Phe Ser Trp Thr Ala Phe 
        195                 200                 205             


Pro Val Ile Trp Ile Leu Ser Ser Thr Gly Phe Cys Val Ile Gly Glu 
    210                 215                 220                 


Asp Gly Ser Val Leu Ala Tyr Leu Val Ala Asp Phe Leu Cys Lys Asn 
225                 230                 235                 240 


Val Tyr Gly Ile Ile Asn Thr Asn Thr Leu Phe Gln Val Leu Asp Gly 
                245                 250                 255     


Glu Trp Lys Pro Glu Thr Arg Asp Thr Asp Gly Lys Ile Ala Thr Asn 
            260                 265                 270         


Arg His Ala His Ile Gly Glu Thr Tyr Leu Glu Met Leu Leu Ala Arg 
        275                 280                 285             


Ile Arg Arg His Arg Glu Gly Glu Leu 
    290                 295         


<210>  66
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic rhodopsin R1ACR_591

<400>  66

Met Val Trp Ser His Val Asp Glu Pro Ala Leu Gly Pro Tyr Gly Ser 
1               5                   10                  15      


Trp Glu Ala Ala Asn Pro Asp Cys Val Ala Leu Gly Leu Thr Thr Ser 
            20                  25                  30          


Lys Asn Thr Lys Met Ile Leu Leu Leu Phe Ala Ser Ile Cys Ala Cys 
        35                  40                  45              


Gln Val Leu Phe Met Ala Ser Arg Ala Pro Arg Ile Thr Trp Glu Ala 
    50                  55                  60                  


Val Tyr Leu Pro Leu Ile Glu Thr Ile Leu Tyr Ala Met Ala Ser Thr 
65                  70                  75                  80  


Gly Asn Gly Gln Leu Arg Leu Gly Asp Gly Arg Val Leu Pro Ile Ala 
                85                  90                  95      


Arg Tyr Cys Ser Trp Leu Ile Thr Cys Pro Ile Met Leu Phe Gln Val 
            100                 105                 110         


Val Gly Leu Tyr Asp Leu Lys Leu Trp Gly Ile Ser Cys Lys His Met 
        115                 120                 125             


Val Met Ala Ala Ala Leu Ile Arg Thr Val Phe Gly Ile Gly Ala Ser 
    130                 135                 140                 


Val Thr Leu Asp Asp Gln Met Arg Trp Val Gln Phe Phe Leu Ser Tyr 
145                 150                 155                 160 


Ala Phe Phe Phe Phe Glu Leu Tyr Cys Ala Tyr Met Ile Phe Gly Ala 
                165                 170                 175     


Ala Leu Lys Gln Phe Gly Glu Val Arg Thr Thr Leu Asn Ser Ile Val 
            180                 185                 190         


Tyr Ser Arg Ile Leu Leu Leu Arg Phe Ile Phe Phe Leu Ser Trp Asn 
        195                 200                 205             


Ser Phe Gly Ile Ile Trp Leu Leu Ser Ser Thr Gly Leu Cys Met Ile 
    210                 215                 220                 


Ser Glu Asp Val Ser Val Leu Ala Tyr Leu Ala Ala Asp Met Leu Cys 
225                 230                 235                 240 


Lys Asn Thr Tyr Gly Ile Ile Asn Ala Asn Thr Leu Phe Arg Val Leu 
                245                 250                 255     


Asp Gly Lys Trp Thr Pro Glu Thr Leu Glu Glu Ala Ala Ser Gly Val 
            260                 265                 270         


Lys Lys Ala Asn Pro Asn His Val Gly Glu Thr Tyr Leu Glu Arg Met 
        275                 280                 285             


Met Ala Gly Ile Arg Gly Ser Ala Lys Pro Glu Glu Asp Pro Val Ala 
    290                 295                 300                 


Ala 
305 


<210>  67
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (R1ACR_053)

<400>  67

Met Gly Leu Asp Thr Ser Ser Gln Thr Asn Met Ile Gln Leu Leu Phe 
1               5                   10                  15      


Ala Ser Ile Cys Phe Cys Gln Val Leu Phe Met Ala Ser Arg Ala Pro 
            20                  25                  30          


Arg Val Thr Trp Glu Ala Val Tyr Leu Pro Leu Val Glu Thr Val Leu 
        35                  40                  45              


Tyr Gly Met Ala Ala Ser Gly Asn Gly Asn Leu Arg Ile Ser Asp Gly 
    50                  55                  60                  


Arg Met Val Pro Met Ala Arg Phe Cys Ser Trp Leu Ile Thr Cys Pro 
65                  70                  75                  80  


Ile Met Leu Leu Gln Val Val Val Met His Asp Val Val Trp Phe Asn 
                85                  90                  95      


Val Ser Thr Arg Tyr Met Val Leu Ala Ala Ser Leu Ile Arg Thr Val 
            100                 105                 110         


Phe Gly Ile Gly Ala Ser Val Thr Thr Asn Asp Thr Met Arg Trp Val 
        115                 120                 125             


Gln Phe Leu Leu Ser Cys Ile Cys Phe Ala Phe Glu Met Val Val Ala 
    130                 135                 140                 


His Gln Thr Tyr Lys Gly Ala Leu Lys Lys Phe Ala Ala Val Lys Thr 
145                 150                 155                 160 


Thr Leu Asn Gly Val Val Tyr Ala Arg Ile Met Phe Leu Arg Phe Leu 
                165                 170                 175     


Phe Phe Phe Ser Trp Asn Ala Phe Pro Ile Ile Trp Ala Leu Ser Ser 
            180                 185                 190         


Thr Gly Leu Cys Leu Ile Ser Glu Asp Ala Ser Val Leu Ser Tyr Leu 
        195                 200                 205             


Val Ala Asp Leu Ile Cys Lys Asn Ile Tyr Gly Ile Thr Asn Ala Asn 
    210                 215                 220                 


Thr Val Phe Arg Val Leu Asp Gly Ala Trp Val Pro Glu Thr Glu Glu 
225                 230                 235                 240 


<210>  68
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (C1ACR_561)

<400>  68

Met Glu Ile Asn Thr Thr Ser Pro Tyr Gly Trp Trp Ala Ala Ala Asn 
1               5                   10                  15      


Pro Glu Cys Val Ala Lys Ala Ala Val Thr Val Asp Ile Gln Ile Phe 
            20                  25                  30          


Gln Leu Cys Trp Cys Ile Ile Cys Ala Cys Gln Ala Phe Phe Phe Ala 
        35                  40                  45              


Ile Arg Tyr Pro Lys Val Thr Trp Glu Phe Val Leu Val Pro Leu Thr 
    50                  55                  60                  


Glu Ala Val Ile Tyr Gly Leu Gly Tyr Ser Gly Ile Gly Tyr Val Val 
65                  70                  75                  80  


Leu Gln Ser Gly Arg Thr Val Ala Trp Met Arg Ile Cys His Trp Leu 
                85                  90                  95      


Ile Thr Val Pro Val Leu Leu Leu Gln Ile Ser Asp Val Ala His Val 
            100                 105                 110         


Arg Phe His Gly Val Asn Leu Ser Ser Leu Gln Val Pro Ile Ser Val 
        115                 120                 125             


Leu Met Ile Val Phe Gly Phe Cys Ala Glu Val Ala Asp Glu Glu Gly 
    130                 135                 140                 


Val Lys Trp Met Phe Phe Val Ile Gly Leu Val Leu Met Phe Gln Val 
145                 150                 155                 160 


Leu Phe Val Gly Tyr His Ser Leu Ser Arg Gly Ile Thr Arg Phe Ser 
                165                 170                 175     


Glu Ala Gly Thr Glu Glu Gly Ala Met Val Ala Asn Arg Leu Arg Ala 
            180                 185                 190         


Met Leu Val Phe Phe Leu Leu Ser Trp Thr Leu His Pro Leu Phe Phe 
        195                 200                 205             


Val Leu Ser Ile Glu Gly Ala Cys Val Met Thr Glu Pro Val Thr Val 
    210                 215                 220                 


Val Leu Tyr Ile Val Leu Asp Leu Phe Ala Lys Asn Ile Phe Gln Ile 
225                 230                 235                 240 


Val Leu Trp Asp Ser Leu Trp Val Arg Leu Thr Gly Lys Trp Lys Val 
                245                 250                 255     


Glu Glu Leu Val Val His Asp Ala Ser Ala Glu Leu Gly Tyr Asp Glu 
            260                 265                 270         


Asp Tyr Lys His Asp Glu Ile Asn Leu Ser Ile Gly Asn Val Pro Val 
        275                 280                 285             


Ser Thr Glu Ser Pro Val Pro Arg Gly Ala Gly Glu Gly Ala 
    290                 295                 300         


<210>  69
<211>  287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (R2ACR_041)

<400>  69

Met Gly Leu Thr Val Thr Ser Asn Thr Lys Val Phe Gln Leu Leu Phe 
1               5                   10                  15      


Ala Cys Val Cys Ala Cys Gln Val Leu Phe Met Ala Ser Arg Ala Pro 
            20                  25                  30          


Arg Val Thr Trp Glu Ala Val Tyr Leu Pro Leu Val Glu Thr Ile Leu 
        35                  40                  45              


Tyr Ala Met Ala Ala Ser Gly Asn Gly Ser Met Arg Leu Ala Asp Gly 
    50                  55                  60                  


Arg Val Ile Pro Ile Gly Arg Phe Cys Ser Trp Leu Ile Thr Cys Pro 
65                  70                  75                  80  


Ile Met Leu Phe Gln Val Val Gly Ile His Glu Leu Lys Trp Ser Gly 
                85                  90                  95      


Val Ser Cys Lys Asn Met Val Met Ala Ala Ser Leu Ile Arg Thr Val 
            100                 105                 110         


Tyr Gly Ile Gly Ala Ser Val Val Ala Asn Asp Ile Met Lys Trp Val 
        115                 120                 125             


Leu Tyr Val Leu Gly Cys Val Cys Leu Ala Phe Glu Phe Leu Val Val 
    130                 135                 140                 


His Ser Ile Phe Ser Ala Gly Leu Lys Lys Phe Ala Ala Phe Arg Ser 
145                 150                 155                 160 


Thr Leu Asn Asp Gly Val Tyr Asn Arg Leu Leu Phe Met Arg Ala Leu 
                165                 170                 175     


Phe Phe Thr Ala Trp Thr Ser Phe Pro Val Ile Trp Val Leu Ala Ser 
            180                 185                 190         


Thr Gly Ile Cys Leu Ile Asp Glu Asn Val Thr Val Leu Ala Tyr Leu 
        195                 200                 205             


Ile Ala Asp Met Leu Cys Lys Asn Met Tyr Gly Ile Ile Asn Ala Asn 
    210                 215                 220                 


Thr Leu Phe Arg Val Leu Asp Gly Ser Trp Thr Pro Glu Thr Leu Glu 
225                 230                 235                 240 


Thr Ser Lys Asn Pro Pro Lys His Glu Val His Glu Thr Tyr Ile Asp 
                245                 250                 255     


Met Ala Met His His Met Arg Pro Ser Lys Ser Lys Thr Arg Glu Ala 
            260                 265                 270         


Ala Ile Glu Leu Glu Glu His Thr Ala Asp Pro Phe Ala Glu Gly 
        275                 280                 285         


<210>  70
<211>  864
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (GcACR_201)

<400>  70

Ala Thr Gly Gly Ala Gly Gly Cys Cys Gly Cys Cys Gly Ala Cys Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gly Gly Ala Cys Gly Thr Gly Gly Gly Cys Gly Gly 
            20                  25                  30          


Cys Gly Gly Cys Gly Ala Cys Cys Thr Gly Thr Gly Gly Ala Ala Cys 
        35                  40                  45              


Gly Thr Gly Ala Ala Cys Ala Cys Cys Gly Gly Cys Thr Gly Cys Cys 
    50                  55                  60                  


Thr Gly Thr Ala Cys Gly Gly Cys Ala Ala Cys Cys Thr Gly Gly Cys 
65                  70                  75                  80  


Cys Ala Gly Cys Gly Cys Cys Ala Gly Cys Cys Cys Cys Cys Thr Gly 
                85                  90                  95      


Gly Thr Gly Cys Gly Cys Cys Ala Cys Thr Thr Cys Gly Ala Gly Cys 
            100                 105                 110         


Thr Gly Gly Cys Cys Thr Gly Gly Gly Cys Cys Gly Thr Gly Thr Gly 
        115                 120                 125             


Cys Thr Gly Cys Cys Thr Gly Ala Cys Cys Cys Ala Gly Gly Cys Cys 
    130                 135                 140                 


Thr Thr Cys Thr Thr Cys Ala Ala Gly Thr Thr Cys Ala Cys Cys Cys 
145                 150                 155                 160 


Ala Gly Thr Gly Gly Cys Cys Cys Cys Gly Cys Gly Cys Cys Gly Cys 
                165                 170                 175     


Cys Thr Gly Gly Gly Ala Gly Gly Gly Cys Gly Thr Gly Thr Ala Cys 
            180                 185                 190         


Ala Thr Cys Cys Cys Cys Cys Thr Gly Thr Gly Cys Gly Ala Gly Ala 
        195                 200                 205             


Cys Cys Gly Thr Gly Cys Ala Gly Thr Ala Cys Ala Gly Cys Cys Thr 
    210                 215                 220                 


Gly Cys Thr Gly Thr Thr Cys Thr Thr Cys Ala Ala Gly Cys Thr Gly 
225                 230                 235                 240 


Gly Gly Cys Thr Ala Cys Ala Thr Cys Cys Ala Gly Gly Thr Gly Gly 
                245                 250                 255     


Gly Cys Gly Thr Gly Ala Ala Cys Cys Ala Gly Gly Gly Cys Gly Cys 
            260                 265                 270         


Cys Thr Ala Cys Cys Thr Gly Cys Cys Cys Thr Gly Gly Gly Thr Gly 
        275                 280                 285             


Cys Gly Cys Thr Ala Cys Ala Gly Cys Thr Thr Cys Thr Gly Gly Ala 
    290                 295                 300                 


Thr Gly Ala Thr Cys Ala Cys Cys Ala Cys Cys Cys Cys Cys Gly Thr 
305                 310                 315                 320 


Gly Cys Thr Gly Cys Thr Gly Ala Ala Cys Cys Ala Gly Ala Thr Cys 
                325                 330                 335     


Cys Ala Gly Cys Ala Gly Ala Thr Cys Thr Gly Cys Gly Ala Gly Gly 
            340                 345                 350         


Thr Gly Ala Ala Gly Ala Thr Cys Thr Gly Gly Gly Gly Cys Gly Cys 
        355                 360                 365             


Cys Cys Gly Cys Ala Thr Gly Gly Gly Cys Cys Cys Cys Gly Thr Gly 
    370                 375                 380                 


Cys Ala Gly Ala Cys Cys Thr Gly Gly Gly Cys Cys Ala Ala Cys Ala 
385                 390                 395                 400 


Thr Cys Gly Cys Cys Ala Thr Gly Gly Thr Gly Ala Cys Cys Cys Thr 
                405                 410                 415     


Gly Gly Gly Cys Ala Thr Cys Ala Gly Cys Gly Gly Cys Gly Cys Cys 
            420                 425                 430         


Cys Thr Gly Ala Thr Cys Cys Ala Gly Ala Ala Cys Cys Cys Cys Ala 
        435                 440                 445             


Cys Cys Ala Thr Gly Ala Ala Gly Thr Gly Gly Cys Thr Gly Thr Gly 
    450                 455                 460                 


Cys Thr Thr Cys Gly Thr Gly Gly Cys Cys Gly Gly Cys Ala Cys Cys 
465                 470                 475                 480 


Cys Thr Gly Cys Thr Gly Gly Gly Cys Gly Cys Cys Cys Thr Gly Ala 
                485                 490                 495     


Thr Cys Thr Thr Cys Cys Thr Gly Gly Thr Gly Gly Cys Cys Thr Thr 
            500                 505                 510         


Cys Cys Thr Gly Ala Thr Cys Thr Thr Cys Cys Ala Cys Ala Ala Gly 
        515                 520                 525             


Gly Cys Cys Ala Gly Cys Gly Ala Gly Cys Ala Gly Thr Thr Cys Ala 
    530                 535                 540                 


Ala Gly Gly Ala Gly Ala Thr Cys Gly Gly Cys Cys Ala Cys Cys Cys 
545                 550                 555                 560 


Cys Ala Ala Gly Gly Cys Cys Gly Ala Cys Cys Gly Cys Gly Thr Gly 
                565                 570                 575     


Gly Thr Gly Ala Ala Gly Thr Ala Cys Cys Thr Gly Thr Gly Gly Thr 
            580                 585                 590         


Ala Cys Cys Thr Gly Cys Ala Gly Gly Thr Gly Thr Gly Cys Thr Thr 
        595                 600                 605             


Cys Thr Thr Cys Ala Gly Cys Ala Gly Cys Thr Gly Gly Ala Gly Cys 
    610                 615                 620                 


Gly Thr Gly Thr Thr Cys Cys Cys Cys Cys Thr Gly Cys Thr Gly Thr 
625                 630                 635                 640 


Gly Gly Ala Thr Cys Ala Thr Cys Ala Gly Cys Gly Cys Cys Cys Ala 
                645                 650                 655     


Gly Gly Gly Cys Ala Cys Cys Thr Gly Cys Ala Thr Cys Gly Cys Cys 
            660                 665                 670         


Ala Ala Cys Gly Ala Gly Gly Ala Cys Ala Thr Cys Gly Thr Gly Ala 
        675                 680                 685             


Gly Cys Ala Gly Cys Ala Thr Cys Cys Ala Cys Ala Thr Cys Cys Cys 
    690                 695                 700                 


Cys Gly Cys Cys Gly Ala Cys Ala Thr Cys Cys Thr Gly Gly Cys Cys 
705                 710                 715                 720 


Ala Ala Gly Ala Ala Cys Gly Thr Gly Thr Thr Cys Gly Gly Cys Cys 
                725                 730                 735     


Thr Gly Ala Thr Cys Ala Thr Cys Thr Gly Gly Cys Ala Cys Ala Thr 
            740                 745                 750         


Cys Cys Gly Cys Thr Thr Cys Cys Ala Cys Cys Thr Gly Thr Gly Cys 
        755                 760                 765             


Gly Ala Cys Gly Gly Cys Thr Ala Cys Thr Gly Gly Gly Ala Cys Ala 
    770                 775                 780                 


Thr Cys Gly Ala Gly Cys Gly Cys Thr Thr Cys Ala Ala Gly Cys Ala 
785                 790                 795                 800 


Gly Ala Ala Gly Cys Thr Gly Cys Thr Gly Cys Ala Gly Gly Ala Cys 
                805                 810                 815     


Ala Ala Gly Cys Thr Gly Cys Thr Gly Gly Cys Cys Cys Thr Gly Thr 
            820                 825                 830         


Thr Cys Gly Ala Cys Ala Ala Cys Cys Cys Cys Gly Ala Gly Gly Ala 
        835                 840                 845             


Gly Cys Thr Gly Cys Gly Cys Cys Ala Gly Gly Ala Cys Cys Ala Cys 
    850                 855                 860                 


<210>  71
<211>  864
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (GcACR_201)

<400>  71
atggaggccg ccgacgagga ggacgtgggc ggcggcgacc tgtggaacgt gaacaccggc       60

tgcctgtacg gcaacctggc cagcgccagc cccctggtga gacacttcga gctggcctgg      120

gccgtgtgct gcctgaccca ggccttcttc aagttcaccc agtggcccag agccgcctgg      180

gagggcgtgt acatccccct gtgcgagacc gtgcagtaca gcctgctgtt cttcaagctg      240

ggctacatcc aggtgggcgt gaaccagggc gcctacctgc cctgggtgag atacagcttc      300

tggatgatca ccacccccgt gctgctgaac cagatccagc agatctgcga ggtgaagatc      360

tggggcgcca gaatgggccc cgtgcagacc tgggccaaca tcgccatggt gaccctgggc      420

atcagcggcg ccctgatcca gaaccccacc atgaagtggc tgtgcttcgt ggccggcacc      480

ctgctgggcg ccctgatctt cctggtggcc ttcctgatct tccacaaggc cagcgagcag      540

ttcaaggaga tcggccaccc caaggccgac agagtggtga agtacctgtg gtacctgcag      600

gtgtgcttct tcagcagctg gagcgtgttc cccctgctgt ggatcatcag cgcccagggc      660

acctgcatcg ccaacgagga catcgtgagc agcatccaca tccccgccga catcctggcc      720

aagaacgtgt tcggcctgat catctggcac atcagattcc acctgtgcga cggctactgg      780

gacatcgaga gattcaagca gaagctgctg caggacaagc tgctggccct gttcgacaac      840

cccgaggagc tgagacagga ccac                                             864


<210>  72
<211>  1710
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (HpACR_213)

<400>  72
atgaccgtga tctacggcca gtgggccgcc cagaaccccg gctgcgtgag catgaccaac       60

atcgacctgg gcgtgcgcac cttcgagctg tgctggggca tcatgtgcgc ctgccaggcc      120

gtgttcttcg ccctgcgcta cccccgcgcc acctgggagt tcgtgatggt gcccctgacc      180

gagtgcttca tctacggcct gggctacagc gagatcggct acatcctgct gtgggacggc      240

cgccaggtgc tgtggacccg caccgtgctg tggctggcca ccgtgcccat cctgctgaac      300

cagatcaacg ccatggccgc cgtgcacatc tacggcgtgg acctgaacat catgcagatg      360

tacttcagca ccctgatgat ctgcctgggc cacaccgccg ccctgaccca caaccagagc      420

ctgaagtggc tgttcttcat catggccatg gccatcttcg gcgtgatctg cttcatcaac      480

tactacacct tcgccgccgc cgagaagcac tacaaggaga gcggcagcga gaacgacctg      540

aagatcgcca agcgcatccg cctgctggcc atcatcttct tcaccagctg gaccatgtac      600

cccctgttct tcgtgctgag cgtggagggc gcctgcgtgg ccagcgagag cgtgatcctg      660

gtgtgcttcg ccctggccga cctgctgagc aagaacgtgt tcggcgtgct gttctgggac      720

accctgtgga acatgcagga cggcaagtgg accagctacg gcaccgtgac cttcttcaag      780

accaccgaca gcgtgaccaa gaccgccatc agcaccgcca tggaggagga gtacagcaag      840

cagaaggtga gccgcatgac cgtgatctac ggccagtggg ccgcccagaa ccccggctgc      900

gtgagcatga ccaacatcga cctgggcgtg cgcaccttcg agctgtgctg gggcatcatg      960

tgcgcctgcc aggccgtgtt cttcgccctg cgctaccccc gcgccacctg ggagttcgtg     1020

atggtgcccc tgaccgagtg cttcatctac ggcctgggct acagcgagat cggctacatc     1080

ctgctgtggg acggccgcca ggtgctgtgg acccgcaccg tgctgtggct ggccaccgtg     1140

cccatcctgc tgaaccagat caacgccatg gccgccgtgc acatctacgg cgtggacctg     1200

aacatcatgc agatgtactt cagcaccctg atgatctgcc tgggccacac cgccgccctg     1260

acccacaacc agagcctgaa gtggctgttc ttcatcatgg ccatggccat cttcggcgtg     1320

atctgcttca tcaactacta caccttcgcc gccgccgaga agcactacaa ggagagcggc     1380

agcgagaacg acctgaagat cgccaagcgc atccgcctgc tggccatcat cttcttcacc     1440

agctggacca tgtaccccct gttcttcgtg ctgagcgtgg agggcgcctg cgtggccagc     1500

gagagcgtga tcctggtgtg cttcgccctg gccgacctgc tgagcaagaa cgtgttcggc     1560

gtgctgttct gggacaccct gtggaacatg caggacggca agtggaccag ctacggcacc     1620

gtgaccttct tcaagaccac cgacagcgtg accaagaccg ccatcagcac cgccatggag     1680

gaggagtaca gcaagcagaa ggtgagccgc                                      1710


<210>  73
<211>  855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (HpACR_213)

<400>  73
atgaccgtga tctacggcca gtgggccgcc cagaaccccg gctgcgtgag catgaccaac       60

atcgacctgg gcgtgagaac cttcgagctg tgctggggca tcatgtgcgc ctgccaggcc      120

gtgttcttcg ccctgagata ccccagagcc acctgggagt tcgtgatggt gcccctgacc      180

gagtgcttca tctacggcct gggctacagc gagatcggct acatcctgct gtgggacggc      240

agacaggtgc tgtggaccag aaccgtgctg tggctggcca ccgtgcccat cctgctgaac      300

cagatcaacg ccatggccgc cgtgcacatc tacggcgtgg acctgaacat catgcagatg      360

tacttcagca ccctgatgat ctgcctgggc cacaccgccg ccctgaccca caaccagagc      420

ctgaagtggc tgttcttcat catggccatg gccatcttcg gcgtgatctg cttcatcaac      480

tactacacct tcgccgccgc cgagaagcac tacaaggaga gcggcagcga gaacgacctg      540

aagatcgcca agagaatcag actgctggcc atcatcttct tcaccagctg gaccatgtac      600

cccctgttct tcgtgctgag cgtggagggc gcctgcgtgg ccagcgagag cgtgatcctg      660

gtgtgcttcg ccctggccga cctgctgagc aagaacgtgt tcggcgtgct gttctgggac      720

accctgtgga acatgcagga cggcaagtgg accagctacg gcaccgtgac cttcttcaag      780

accaccgaca gcgtgaccaa gaccgccatc agcaccgcca tggaggagga gtacagcaag      840

cagaaggtga gcaga                                                       855


<210>  74
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (HaACR_359)

<400>  74
atggccaccc ccgcccccgc cggcgccccc ctgaccacca cccccgtgcc ctacggccag       60

tgggaggcca acaaccccgc ctgcgtggcc ctgttcacca tgcccgccca ggtgcagacc      120

ctgatgctgt gctggtgcat catctgcagc tgccaggcca tcttcctgat gagccgctgg      180

ccccgcgtgg gctgggagct ggtggccgcc cccgccatcg agagcatcgt gtacggcctg      240

ggctaccagg gcatcggcta cgtgaagatg gccagcggcc agcccctggc ctacgcccgc      300

ttcttcatga tgatcaccat cacccccatg atcctgctgg acatcaacaa gctggccagc      360

gtgcgcctgc tgggcctgaa catgaacagc atgcagctgg gcgccaacgt gctgctgtgg      420

atgttctggc aggccagcac catgagcacc ctggtgggcc tgaagtgggt gttcttcgtg      480

ctgggcctgc tgtgcctggg cctggtgctg ggcaccagct tcatgatctt cgccgccgcc      540

cgccagagct tcctgctgaa gggcaccggc gccggcgact gggtggccca gcgcatcacc      600

tacctgcaga tggccttcct gcccacctgg accgcctaca tggtgctgtt cgtgctgagc      660

ggcgagggcg cctgcatcgc cggcgagggc gtgatcctgc ccatcgccat cgtgatggac      720

ctgttccaga agaacgtgca cggcctgatc atctggagca ccttctggaa cttcctgggc      780

ggcagctgga accccgagcg cctggccgag gagcgcgccc ccagccgcat cgccggcctg      840

aaggtgatcg agaacaacgc ccaccccgtg gac                                   873


<210>  75
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (HaACR_359)

<400>  75
atggccaccc ccgcccccgc cggcgccccc ctgaccacca cccccgtgcc ctacggccag       60

tgggaggcca acaaccccgc ctgcgtggcc ctgttcacca tgcccgccca ggtgcagacc      120

ctgatgctgt gctggtgcat catctgcagc tgccaggcca tcttcctgat gagcagatgg      180

cccagagtgg gctgggagct ggtggccgcc cccgccatcg agagcatcgt gtacggcctg      240

ggctaccagg gcatcggcta cgtgaagatg gccagcggcc agcccctggc ctacgccaga      300

ttcttcatga tgatcaccat cacccccatg atcctgctgg acatcaacaa gctggccagc      360

gtgagactgc tgggcctgaa catgaacagc atgcagctgg gcgccaacgt gctgctgtgg      420

atgttctggc aggccagcac catgagcacc ctggtgggcc tgaagtgggt gttcttcgtg      480

ctgggcctgc tgtgcctggg cctggtgctg ggcaccagct tcatgatctt cgccgccgcc      540

agacagagct tcctgctgaa gggcaccggc gccggcgact gggtggccca gagaatcacc      600

tacctgcaga tggccttcct gcccacctgg accgcctaca tggtgctgtt cgtgctgagc      660

ggcgagggcg cctgcatcgc cggcgagggc gtgatcctgc ccatcgccat cgtgatggac      720

ctgttccaga agaacgtgca cggcctgatc atctggagca ccttctggaa cttcctgggc      780

ggcagctgga accccgagag actggccgag gagagagccc ccagcagaat cgccggcctg      840

aaggtgatcg agaacaacgc ccaccccgtg gac                                   873


<210>  76
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (HrACR_495)

<400>  76
atggccaccc ccggccccgc cgccgtgccc agcatgacca ccacccccgc cccctacggc       60

acctgggagg ccaacaaccc cagctgcgtg gccctgttca acagcagccc ccagatccag      120

accctgatgc tgtgctggtg catcatctgc acctgccaga gcatcttcct gatgagccgc      180

tggccccgcg tgggctggga gctggtggcc gcccccgccg tggagtgcat cgtgtacggc      240

ctgggctacc agggcatcgg ctacgtgaag atggccagcg gccagcagct ggcctacgcc      300

cgcttcttca tgatgatcac cgtgaccctg atgatcctga tcgacgtgaa caagctggcc      360

agcgtgcgcc tgctgggcct gaacatgaac agcatgcagc tggccgccaa cctgctgctg      420

tggatgttct ggcaggccag caccatgagc accctgagcg gcctgaagtg ggtgctgttc      480

gtgctgggcc tgatctgcct gggcatcgtg ctgggcacca gcttcatgat cttcagcgcc      540

gcccgccagg gcttcctgga caagaacacc ggcgccggcg actgggtggc ccagcgcatc      600

gtgttcctgg aggtggtgtt cttccccacc tgggccggct acatggtgct gtacgtgatc      660

agcggcgagg gcgcctgcat cgcccccgag accgtgatca tccccgtggc catcgtgctg      720

gacctgttcc agaagaacgt gcacggcctg atcatctgga gcaccttctg gaacttcctg      780

ggcggcagct ggaaccccgg ccgcctggcc gaggagcgcg cccccagccg cctggccggc      840

ctgaaggtga tcgagaacac cgcccacggc ttcgacgacg aggccctgag cgagggcttc      900


<210>  77
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (HrACR_495)

<400>  77
atggccaccc ccggccccgc cgccgtgccc agcatgacca ccacccccgc cccctacggc       60

acctgggagg ccaacaaccc cagctgcgtg gccctgttca acagcagccc ccagatccag      120

accctgatgc tgtgctggtg catcatctgc acctgccaga gcatcttcct gatgagcaga      180

tggcccagag tgggctggga gctggtggcc gcccccgccg tggagtgcat cgtgtacggc      240

ctgggctacc agggcatcgg ctacgtgaag atggccagcg gccagcagct ggcctacgcc      300

agattcttca tgatgatcac cgtgaccctg atgatcctga tcgacgtgaa caagctggcc      360

agcgtgagac tgctgggcct gaacatgaac agcatgcagc tggccgccaa cctgctgctg      420

tggatgttct ggcaggccag caccatgagc accctgagcg gcctgaagtg ggtgctgttc      480

gtgctgggcc tgatctgcct gggcatcgtg ctgggcacca gcttcatgat cttcagcgcc      540

gccagacagg gcttcctgga caagaacacc ggcgccggcg actgggtggc ccagagaatc      600

gtgttcctgg aggtggtgtt cttccccacc tgggccggct acatggtgct gtacgtgatc      660

agcggcgagg gcgcctgcat cgcccccgag accgtgatca tccccgtggc catcgtgctg      720

gacctgttcc agaagaacgt gcacggcctg atcatctgga gcaccttctg gaacttcctg      780

ggcggcagct ggaaccccgg cagactggcc gaggagagag cccccagcag actggccggc      840

ctgaaggtga tcgagaacac cgcccacggc ttcgacgacg aggccctgag cgagggcttc      900


<210>  78
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (PsuACR_353)

<400>  78
atggaggtgg agatggagat ggagatggag ggcctgggca acagcaccag catgttcgag       60

gaggtggtgg gctgcgacct gggcgccagc cccgtgggcg agaccgagat gcacgtggtg      120

cagtggatcg gcagcttcat ctgcatcttc cagtgcctgt ggttcctgag caagtggccc      180

aacttcacct gggacacccc ctacatcccc gccgtggagg ccgtgggcta cggcctgatg      240

gccaacggct tcggctacgc cgagctgttc gagggcgagc gccacgtgcc ctggctgcgc      300

tacagcatct gggtgctgag cacccccgtg ctgctgtggg acatccagga catcctggac      360

gccttctacc gcggcacccg cctggccccc gtgcagagcc tggccaacct gttcctgctg      420

tgcttcggct tcatcggcgc catcgagcac gtgctggccg tgaagtacct gtgctacagc      480

atcggcgtga tgatgctggg cgtggtgttc ttctgcgcct acaacatcgt gggccaggcc      540

gtggccaact tcgaggccac cgacaccgcc cagggccgcc tggtggcctt ccgcctgaag      600

ctgatcgcct gcatcttcat gaccagcttc agcggctacc ccatcctgtg gatcctgagc      660

aaccagggcc tgtgcctggt gcccgagatg atcatcgagg tggtgcacat ccccctggac      720

ctgatcgcca agaacctgtt caccctgctg acctggcaca cccactacat cctgctgaac      780

ggcgactgga gctgcgaggc catggtggcc cgcctgcagg agcagaacga catcgagatg      840

gcccagcagc cccgcgaggc cggccagctg cgcaaggacc tgatgcagaa ggcccagggc      900


<210>  79
<211>  900
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (PsuACR_353)

<400>  79
atggaggtgg agatggagat ggagatggag ggcctgggca acagcaccag catgttcgag       60

gaggtggtgg gctgcgacct gggcgccagc cccgtgggcg agaccgagat gcacgtggtg      120

cagtggatcg gcagcttcat ctgcatcttc cagtgcctgt ggttcctgag caagtggccc      180

aacttcacct gggacacccc ctacatcccc gccgtggagg ccgtgggcta cggcctgatg      240

gccaacggct tcggctacgc cgagctgttc gagggcgaga gacacgtgcc ctggctgaga      300

tacagcatct gggtgctgag cacccccgtg ctgctgtggg acatccagga catcctggac      360

gccttctaca gaggcaccag actggccccc gtgcagagcc tggccaacct gttcctgctg      420

tgcttcggct tcatcggcgc catcgagcac gtgctggccg tgaagtacct gtgctacagc      480

atcggcgtga tgatgctggg cgtggtgttc ttctgcgcct acaacatcgt gggccaggcc      540

gtggccaact tcgaggccac cgacaccgcc cagggcagac tggtggcctt cagactgaag      600

ctgatcgcct gcatcttcat gaccagcttc agcggctacc ccatcctgtg gatcctgagc      660

aaccagggcc tgtgcctggt gcccgagatg atcatcgagg tggtgcacat ccccctggac      720

ctgatcgcca agaacctgtt caccctgctg acctggcaca cccactacat cctgctgaac      780

ggcgactgga gctgcgaggc catggtggcc agactgcagg agcagaacga catcgagatg      840

gcccagcagc ccagagaggc cggccagctg agaaaggacc tgatgcagaa ggcccagggc      900


<210>  80
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (RaACR_687)

<400>  80
atgggcgaca tgagccacat cgagaccgtg tactacgtga acggcaccga ggtggacccc       60

tggacccacc gctgccagct gggcgtgccc ggcggcagcc agggcatcca caccttccag      120

ctgacctgga gcctgatctg caccgcccag gccatcttcc tgatgaccaa gtggcccaag      180

gtgggctggg aggccatcta catgccctgc tgcgaggccc tgagctacgg cctgctgagc      240

gccggccacg gctacctgaa gctgcacggc gagtggcact acatcccctg gatccgctac      300

gccgcctgga tggtgaccac ccccgtgctg ctgaaccagg tgcagggcgt gctggacgtg      360

aaggtgggcc acctgcgcct ggcccccatc cagagcctgg ccaacctgat catgatcgtg      420

atgggcgtga gcgcccacct gcaggagaac atcgcctgga agtgggtgtt cttcctgatc      480

ggctgcgtga tggccctggt gatctactgg gtggcctggc tggtgttcag cacccagatc      540

aagtactacg ccgagaccaa gaccgccgtg ggcgaccgcg tggtgttcca gctgaagctg      600

atcgccgtgg ccttctacgt gggctggagc gccttccccc tgatctggat gctgagcagc      660

gagggcctgt gcgccatcga ggagcacatc gccgccgccg cccacatccc cgccgacgtg      720

ctgagcaaga acatcttcgg cctgctgatg tggcacaccc gctggatcgt gctgggcggc      780

tactgggacg tgaacaagtt caaggagacc atcgcccagc agaagctgga ggaggccaag      840

ggcgaggaga ccccccagga gaagcgcaag gccctgatgg gccaggccga ggcctgcttc      900

aagatggccg acgcctgc                                                    918


<210>  81
<211>  918
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (RaACR_687)

<400>  81
atgggcgaca tgagccacat cgagaccgtg tactacgtga acggcaccga ggtggacccc       60

tggacccaca gatgccagct gggcgtgccc ggcggcagcc agggcatcca caccttccag      120

ctgacctgga gcctgatctg caccgcccag gccatcttcc tgatgaccaa gtggcccaag      180

gtgggctggg aggccatcta catgccctgc tgcgaggccc tgagctacgg cctgctgagc      240

gccggccacg gctacctgaa gctgcacggc gagtggcact acatcccctg gatcagatac      300

gccgcctgga tggtgaccac ccccgtgctg ctgaaccagg tgcagggcgt gctggacgtg      360

aaggtgggcc acctgagact ggcccccatc cagagcctgg ccaacctgat catgatcgtg      420

atgggcgtga gcgcccacct gcaggagaac atcgcctgga agtgggtgtt cttcctgatc      480

ggctgcgtga tggccctggt gatctactgg gtggcctggc tggtgttcag cacccagatc      540

aagtactacg ccgagaccaa gaccgccgtg ggcgacagag tggtgttcca gctgaagctg      600

atcgccgtgg ccttctacgt gggctggagc gccttccccc tgatctggat gctgagcagc      660

gagggcctgt gcgccatcga ggagcacatc gccgccgccg cccacatccc cgccgacgtg      720

ctgagcaaga acatcttcgg cctgctgatg tggcacacca gatggatcgt gctgggcggc      780

tactgggacg tgaacaagtt caaggagacc atcgcccagc agaagctgga ggaggccaag      840

ggcgaggaga ccccccagga gaagagaaag gccctgatgg gccaggccga ggcctgcttc      900

aagatggccg acgcctgc                                                    918


<210>  82
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (RlACR_497)

<400>  82
atggagtacc agagcctgga cgacttcccc ctggagaccc tgtacttccg caacggcacc       60

gaggtggacc cctacgacca ccgctgcaag ctgggcatcc ccggcggcag ccagggcatc      120

cacaccttcc agctggtgtg ggccctgctg tgcgccgccc aggccctgtt cctgttcagc      180

aagtggccca aggtgggctg ggaggccatg tacatgccct gctgcgaggc cctgagctac      240

ggcctgctga gcagcggcta cggctacatg aagctgcacg gcgagttcca ctacctgccc      300

tggatccgct acgccgcctg gatcgtgacc acccccgtgc tgctgaacca ggtgcagggc      360

atgatcgaca tcaagatcgg cagcctgcgc ctggccccca tccagagcct ggccaacctg      420

atcatgatca tcatgggcgt gagcgcccac ctgcaggaga accacgcctg gaagtggctg      480

ttcttcttcg tgggctgcgt gatgtgcgcc gtgatctact acatcgcctg gctgcagttc      540

gccaaggtga acgagctgta cgccgccacc aagaccgaga tcggcgacaa ggtgtgcttc      600

cagctgaagc tgatcatgtt ctgcttctac gtgggctgga gcatgttcag cgtgatctgg      660

ctgctgagca gcgagggcct gtgcctgatc gaggagcaca tcagcgccgc cgcccacatc      720

cccggcgaca tcctgagcaa gaacagcttc ggcctgctga tgtggtacac ccgctggatc      780

accctgggcg gcgcctggga catcaacaag ttcctggaga agcaggccaa ggagaaggcc      840

gaggccgtgc tgacccccgc cgagaagcgc aaggccatca tgaagcaggc cgaggcctgc      900

ttcagcatgg ccgacgcctg cctgcagcag gccaac                                936


<210>  83
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (RlACR_497)

<400>  83
atggagtacc agagcctgga cgacttcccc ctggagaccc tgtacttcag aaacggcacc       60

gaggtggacc cctacgacca cagatgcaag ctgggcatcc ccggcggcag ccagggcatc      120

cacaccttcc agctggtgtg ggccctgctg tgcgccgccc aggccctgtt cctgttcagc      180

aagtggccca aggtgggctg ggaggccatg tacatgccct gctgcgaggc cctgagctac      240

ggcctgctga gcagcggcta cggctacatg aagctgcacg gcgagttcca ctacctgccc      300

tggatcagat acgccgcctg gatcgtgacc acccccgtgc tgctgaacca ggtgcagggc      360

atgatcgaca tcaagatcgg cagcctgaga ctggccccca tccagagcct ggccaacctg      420

atcatgatca tcatgggcgt gagcgcccac ctgcaggaga accacgcctg gaagtggctg      480

ttcttcttcg tgggctgcgt gatgtgcgcc gtgatctact acatcgcctg gctgcagttc      540

gccaaggtga acgagctgta cgccgccacc aagaccgaga tcggcgacaa ggtgtgcttc      600

cagctgaagc tgatcatgtt ctgcttctac gtgggctgga gcatgttcag cgtgatctgg      660

ctgctgagca gcgagggcct gtgcctgatc gaggagcaca tcagcgccgc cgcccacatc      720

cccggcgaca tcctgagcaa gaacagcttc ggcctgctga tgtggtacac cagatggatc      780

accctgggcg gcgcctggga catcaacaag ttcctggaga agcaggccaa ggagaaggcc      840

gaggccgtgc tgacccccgc cgagaagaga aaggccatca tgaagcaggc cgaggcctgc      900

ttcagcatgg ccgacgcctg cctgcagcag gccaac                                936


<210>  84
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (RsACR_665)

<400>  84
atggactaca ccagcctgga cgacttcccc ctggagaccc tgtacttccg caacggcacc       60

gaggtggacc cctacgacca ccgctgcaag ctgggcatcc ccggcggcag ccagggcatc      120

cacaccttcc agctggtgtg ggccctgctg tgcgccgccc aggccctgtt cctgttcagc      180

aagtggccca aggtgggctg ggaggccatg tacatgccct gctgcgaggc cctgagctac      240

ggcctgctga gcagcggcta cggctacatg aagctgcacg gcgagttcca ctacctgccc      300

tggatccgct acgccgcctg gctggtgacc acccccgtgc tgctgaacca ggtgcagggc      360

atgatcgaca tcaagatcgg cagcctgcgc ctggccccca tccagagcct ggccaacctg      420

atcatgatca tcatgggcgt gagcgcccac ctgcaggaga accacgcctg gaagtggctg      480

ttcttcttcg tgggctgcgt gatgtgcgcc gtgatctact acatcgcctg gctgcagttc      540

gccaaggtga acgagctgta cgccgccacc aagaccgaga tcggcgacaa ggtgtgcttc      600

cagctgaagc tgatcatgtt ctgcttctac gtgggctgga gcatgttcag cgtgatctgg      660

ctgctgagca gcgagggcct gtgcctgatc gaggagcaca tcagcgccgc cgcccacatc      720

cccggcgaca tcctgagcaa gaacagcttc ggcctgctga tgtggtacac ccgctggatc      780

accctgggcg gcgcctggga catcaacaag ttcctggaga agcaggccaa ggagaaggcc      840

gaggccgtgc tgacccccgc cgagaagcgc aaggccatca tgaagcaggc cgaggcctgc      900

ttcagcatgg ccgacgcctg c                                                921


<210>  85
<211>  921
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (RsACR_665)

<400>  85
atggactaca ccagcctgga cgacttcccc ctggagaccc tgtacttcag aaacggcacc       60

gaggtggacc cctacgacca cagatgcaag ctgggcatcc ccggcggcag ccagggcatc      120

cacaccttcc agctggtgtg ggccctgctg tgcgccgccc aggccctgtt cctgttcagc      180

aagtggccca aggtgggctg ggaggccatg tacatgccct gctgcgaggc cctgagctac      240

ggcctgctga gcagcggcta cggctacatg aagctgcacg gcgagttcca ctacctgccc      300

tggatcagat acgccgcctg gctggtgacc acccccgtgc tgctgaacca ggtgcagggc      360

atgatcgaca tcaagatcgg cagcctgaga ctggccccca tccagagcct ggccaacctg      420

atcatgatca tcatgggcgt gagcgcccac ctgcaggaga accacgcctg gaagtggctg      480

ttcttcttcg tgggctgcgt gatgtgcgcc gtgatctact acatcgcctg gctgcagttc      540

gccaaggtga acgagctgta cgccgccacc aagaccgaga tcggcgacaa ggtgtgcttc      600

cagctgaagc tgatcatgtt ctgcttctac gtgggctgga gcatgttcag cgtgatctgg      660

ctgctgagca gcgagggcct gtgcctgatc gaggagcaca tcagcgccgc cgcccacatc      720

cccggcgaca tcctgagcaa gaacagcttc ggcctgctga tgtggtacac cagatggatc      780

accctgggcg gcgcctggga catcaacaag ttcctggaga agcaggccaa ggagaaggcc      840

gaggccgtgc tgacccccgc cgagaagaga aaggccatca tgaagcaggc cgaggcctgc      900

ttcagcatgg ccgacgcctg c                                                921


<210>  86
<211>  855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (R1ACR_653)

<400>  86
atgccctacg acaactacgg ctggtgggag cgcgagaacg ccgactgcat cagcaagatg       60

gacgccaagc tggaccagat gcacctggtg cagctggcca tgagcatgct gtgcttctgc      120

cagctggtgt tcatgaccag ccgcttcccc aagcaggcct gggaggccat ctacctgccc      180

gccgccgagt gcgtgctgta cgccatggcc gccagcggca acggctacct gcgcctggcc      240

aacggccgcc tgctgccctg ggcccgcatg gccagctggc tggccacctg ccccgtgatg      300

ctgaaccaga tcaacaccat cagccccctg aagctgtacg gcatcaacct gaacaacgtg      360

cagatcgccc tgagcgtggt gcgcgtggtg aacggcgtga gcgccagcag cgtggacgac      420

gacagcctga agtggggctt cttcttcatg ggcgtgttct gcctggtgat cgagttcagc      480

atcgcctaca acatcttcgc cctgggcatg gccaagttca aggaggccgg caaggacagc      540

gacatctgcg cccgcgcctg cgaccgcctg caggtgctgc gcggcatctt cttcagcgcc      600

tgggccatgt tccccatcat ctggctgttc agcccccagg gcacctgcct gctgggcgag      660

gacgtgatcc ccctgctgta cctgttcgcc gacctggtgt gcaagaactg cttcggcatc      720

ctgtggtacg acaccacctg gcgcctgctg gacggcaagg gctggaaccc cgagctgcag      780

ctgaccgaca acgaggtgga ggagctggtg cacgccaagg aggaggtgga ggaccaccac      840

cacccccacg acgcc                                                       855


<210>  87
<211>  855
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (R1ACR_653)

<400>  87
atgccctacg acaactacgg ctggtgggag agagagaacg ccgactgcat cagcaagatg       60

gacgccaagc tggaccagat gcacctggtg cagctggcca tgagcatgct gtgcttctgc      120

cagctggtgt tcatgaccag cagattcccc aagcaggcct gggaggccat ctacctgccc      180

gccgccgagt gcgtgctgta cgccatggcc gccagcggca acggctacct gagactggcc      240

aacggcagac tgctgccctg ggccagaatg gccagctggc tggccacctg ccccgtgatg      300

ctgaaccaga tcaacaccat cagccccctg aagctgtacg gcatcaacct gaacaacgtg      360

cagatcgccc tgagcgtggt gagagtggtg aacggcgtga gcgccagcag cgtggacgac      420

gacagcctga agtggggctt cttcttcatg ggcgtgttct gcctggtgat cgagttcagc      480

atcgcctaca acatcttcgc cctgggcatg gccaagttca aggaggccgg caaggacagc      540

gacatctgcg ccagagcctg cgacagactg caggtgctga gaggcatctt cttcagcgcc      600

tgggccatgt tccccatcat ctggctgttc agcccccagg gcacctgcct gctgggcgag      660

gacgtgatcc ccctgctgta cctgttcgcc gacctggtgt gcaagaactg cttcggcatc      720

ctgtggtacg acaccacctg gagactgctg gacggcaagg gctggaaccc cgagctgcag      780

ctgaccgaca acgaggtgga ggagctggtg cacgccaagg aggaggtgga ggaccaccac      840

cacccccacg acgcc                                                       855


<210>  88
<211>  891
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic rhodopsin R1ACR_6367

<400>  88
atgagcgcca tcaccgaccc cgccctgggc ctgtacggca cctgggaggc cgccaacaag       60

gagtgcgtgg acaagggcgt ggagttcagc agcaacaccc gcatgatcgt gctgctgttc      120

gccagcgtgt gcttctgcca gaccgtgtac atgaccagcc gcgccccccg cgtgaactgg      180

gagggctgct acctgcccct gtgcgagacc ttcctgtacg gcctggccgc cagcggcaac      240

ggcatgatcc gcctgagcaa cggccgcatg gtgcccatgg cccgcttctg cagctggctg      300

gtgacctgcc ccatcatgct gatgagcgtg ctggccatcc acgacgtgcg ctggatgggc      360

gtgcccgtga agaacatggt gatcgccgcc accctgatcc gcaccgtgct gggcatcggc      420

gccagcagca ccatcaccga gaccctgcgc tgggtgcagt actgcatcgc ctgcgccgtg      480

ttcgtgttcg agctgaccat ggtgaaccag ctgttcatcg ccggcctgca gaagttcggc      540

gtggtgaaga ccaagctgaa cgacatggtg tacatgcgca tcatgatcct gcgcgccctg      600

ttcttcttca gctggaccgc cttccccgtg atctggatcc tgagcagcac cggcttctgc      660

gtgatcggcg aggacggcag cgtgctggcc tacctggtgg ccgacttcct gtgcaagaac      720

gtgtacggca tcatcaacac caacaccctg ttccaggtgc tggacggcga gtggaagccc      780

gagacccgcg acaccgacgg caagatcgcc accaaccgcc acgcccacat cggcgagacc      840

tacctggaga tgctgctggc ccgcatccgc cgccaccgcg agggcgagct g               891


<210>  89
<211>  891
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (R1ACR_6367)

<400>  89
atgagcgcca tcaccgaccc cgccctgggc ctgtacggca cctgggaggc cgccaacaag       60

gagtgcgtgg acaagggcgt ggagttcagc agcaacacca gaatgatcgt gctgctgttc      120

gccagcgtgt gcttctgcca gaccgtgtac atgaccagca gagcccccag agtgaactgg      180

gagggctgct acctgcccct gtgcgagacc ttcctgtacg gcctggccgc cagcggcaac      240

ggcatgatca gactgagcaa cggcagaatg gtgcccatgg ccagattctg cagctggctg      300

gtgacctgcc ccatcatgct gatgagcgtg ctggccatcc acgacgtgag atggatgggc      360

gtgcccgtga agaacatggt gatcgccgcc accctgatca gaaccgtgct gggcatcggc      420

gccagcagca ccatcaccga gaccctgaga tgggtgcagt actgcatcgc ctgcgccgtg      480

ttcgtgttcg agctgaccat ggtgaaccag ctgttcatcg ccggcctgca gaagttcggc      540

gtggtgaaga ccaagctgaa cgacatggtg tacatgagaa tcatgatcct gagagccctg      600

ttcttcttca gctggaccgc cttccccgtg atctggatcc tgagcagcac cggcttctgc      660

gtgatcggcg aggacggcag cgtgctggcc tacctggtgg ccgacttcct gtgcaagaac      720

gtgtacggca tcatcaacac caacaccctg ttccaggtgc tggacggcga gtggaagccc      780

gagaccagag acaccgacgg caagatcgcc accaacagac acgcccacat cggcgagacc      840

tacctggaga tgctgctggc cagaatcaga agacacagag agggcgagct g               891


<210>  90
<211>  915
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (R1ACR_591)

<400>  90
atggtgtgga gccacgtgga cgagcccgcc ctgggcccct acggcagctg ggaggccgcc       60

aaccccgact gcgtggccct gggcctgacc accagcaaga acaccaagat gatcctgctg      120

ctgttcgcca gcatctgcgc ctgccaggtg ctgttcatgg ccagccgcgc cccccgcatc      180

acctgggagg ccgtgtacct gcccctgatc gagaccatcc tgtacgccat ggccagcacc      240

ggcaacggcc agctgcgcct gggcgacggc cgcgtgctgc ccatcgcccg ctactgcagc      300

tggctgatca cctgccccat catgctgttc caggtggtgg gcctgtacga cctgaagctg      360

tggggcatca gctgcaagca catggtgatg gccgccgccc tgatccgcac cgtgttcggc      420

atcggcgcca gcgtgaccct ggacgaccag atgcgctggg tgcagttctt cctgagctac      480

gccttcttct tcttcgagct gtactgcgcc tacatgatct tcggcgccgc cctgaagcag      540

ttcggcgagg tgcgcaccac cctgaacagc atcgtgtaca gccgcatcct gctgctgcgc      600

ttcatcttct tcctgagctg gaacagcttc ggcatcatct ggctgctgag cagcaccggc      660

ctgtgcatga tcagcgagga cgtgagcgtg ctggcctacc tggccgccga catgctgtgc      720

aagaacacct acggcatcat caacgccaac accctgttcc gcgtgctgga cggcaagtgg      780

acccccgaga ccctggagga ggccgccagc ggcgtgaaga aggccaaccc caaccacgtg      840

ggcgagacct acctggagcg catgatggcc ggcatccgcg gcagcgccaa gcccgaggag      900

gaccccgtgg ccgcc                                                       915


<210>  91
<211>  915
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (R1ACR_591)

<400>  91
atggtgtgga gccacgtgga cgagcccgcc ctgggcccct acggcagctg ggaggccgcc       60

aaccccgact gcgtggccct gggcctgacc accagcaaga acaccaagat gatcctgctg      120

ctgttcgcca gcatctgcgc ctgccaggtg ctgttcatgg ccagcagagc ccccagaatc      180

acctgggagg ccgtgtacct gcccctgatc gagaccatcc tgtacgccat ggccagcacc      240

ggcaacggcc agctgagact gggcgacggc agagtgctgc ccatcgccag atactgcagc      300

tggctgatca cctgccccat catgctgttc caggtggtgg gcctgtacga cctgaagctg      360

tggggcatca gctgcaagca catggtgatg gccgccgccc tgatcagaac cgtgttcggc      420

atcggcgcca gcgtgaccct ggacgaccag atgagatggg tgcagttctt cctgagctac      480

gccttcttct tcttcgagct gtactgcgcc tacatgatct tcggcgccgc cctgaagcag      540

ttcggcgagg tgagaaccac cctgaacagc atcgtgtaca gcagaatcct gctgctgaga      600

ttcatcttct tcctgagctg gaacagcttc ggcatcatct ggctgctgag cagcaccggc      660

ctgtgcatga tcagcgagga cgtgagcgtg ctggcctacc tggccgccga catgctgtgc      720

aagaacacct acggcatcat caacgccaac accctgttca gagtgctgga cggcaagtgg      780

acccccgaga ccctggagga ggccgccagc ggcgtgaaga aggccaaccc caaccacgtg      840

ggcgagacct acctggagag aatgatggcc ggcatcagag gcagcgccaa gcccgaggag      900

gaccccgtgg ccgcc                                                       915


<210>  92
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (R1ACR_053)

<400>  92
atgggcctgg acaccagcag ccagaccaac atgatccagc tgctgttcgc cagcatctgc       60

ttctgccagg tgctgttcat ggccagccgc gccccccgcg tgacctggga ggccgtgtac      120

ctgcccctgg tggagaccgt gctgtacggc atggccgcca gcggcaacgg caacctgcgc      180

atcagcgacg gccgcatggt gcccatggcc cgcttctgca gctggctgat cacctgcccc      240

atcatgctgc tgcaggtggt ggtgatgcac gacgtggtgt ggttcaacgt gagcacccgc      300

tacatggtgc tggccgccag cctgatccgc accgtgttcg gcatcggcgc cagcgtgacc      360

accaacgaca ccatgcgctg ggtgcagttc ctgctgagct gcatctgctt cgccttcgag      420

atggtggtgg cccaccagac ctacaagggc gccctgaaga agttcgccgc cgtgaagacc      480

accctgaacg gcgtggtgta cgcccgcatc atgttcctgc gcttcctgtt cttcttcagc      540

tggaacgcct tccccatcat ctgggccctg agcagcaccg gcctgtgcct gatcagcgag      600

gacgccagcg tgctgagcta cctggtggcc gacctgatct gcaagaacat ctacggcatc      660

accaacgcca acaccgtgtt ccgcgtgctg gacggcgcct gggtgcccga gaccgaggag      720


<210>  93
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (R1ACR_053)

<400>  93
atgggcctgg acaccagcag ccagaccaac atgatccagc tgctgttcgc cagcatctgc       60

ttctgccagg tgctgttcat ggccagcaga gcccccagag tgacctggga ggccgtgtac      120

ctgcccctgg tggagaccgt gctgtacggc atggccgcca gcggcaacgg caacctgaga      180

atcagcgacg gcagaatggt gcccatggcc agattctgca gctggctgat cacctgcccc      240

atcatgctgc tgcaggtggt ggtgatgcac gacgtggtgt ggttcaacgt gagcaccaga      300

tacatggtgc tggccgccag cctgatcaga accgtgttcg gcatcggcgc cagcgtgacc      360

accaacgaca ccatgagatg ggtgcagttc ctgctgagct gcatctgctt cgccttcgag      420

atggtggtgg cccaccagac ctacaagggc gccctgaaga agttcgccgc cgtgaagacc      480

accctgaacg gcgtggtgta cgccagaatc atgttcctga gattcctgtt cttcttcagc      540

tggaacgcct tccccatcat ctgggccctg agcagcaccg gcctgtgcct gatcagcgag      600

gacgccagcg tgctgagcta cctggtggcc gacctgatct gcaagaacat ctacggcatc      660

accaacgcca acaccgtgtt cagagtgctg gacggcgcct gggtgcccga gaccgaggag      720


<210>  94
<211>  906
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (C1ACR_561)

<400>  94
atggagatca acaccaccag cccctacggc tggtgggccg ccgccaaccc cgagtgcgtg       60

gccaaggccg ccgtgaccgt ggacatccag atcttccagc tgtgctggtg catcatctgc      120

gcctgccagg ccttcttctt cgccatccgc taccccaagg tgacctggga gttcgtgctg      180

gtgcccctga ccgaggccgt gatctacggc ctgggctaca gcggcatcgg ctacgtggtg      240

ctgcagagcg gccgcaccgt ggcctggatg cgcatctgcc actggctgat caccgtgccc      300

gtgctgctgc tgcagatcag cgacgtggcc cacgtgcgct tccacggcgt gaacctgagc      360

agcctgcagg tgcccatcag cgtgctgatg atcgtgttcg gcttctgcgc cgaggtggcc      420

gacgaggagg gcgtgaagtg gatgttcttc gtgatcggcc tggtgctgat gttccaggtg      480

ctgttcgtgg gctaccacag cctgagccgc ggcatcaccc gcttcagcga ggccggcacc      540

gaggagggcg ccatggtggc caaccgcctg cgcgccatgc tggtgttctt cctgctgagc      600

tggaccctgc accccctgtt cttcgtgctg agcatcgagg gcgcctgcgt gatgaccgag      660

cccgtgaccg tggtgctgta catcgtgctg gacctgttcg ccaagaacat cttccagatc      720

gtgctgtggg acagcctgtg ggtgcgcctg accggcaagt ggaaggtgga ggagctggtg      780

gtgcacgacg ccagcgccga gctgggctac gacgaggact acaagcacga cgagatcaac      840

ctgagcatcg gcaacgtgcc cgtgagcacc gagagccccg tgccccgcgg cgccggcgag      900

ggcgcc                                                                 906


<210>  95
<211>  906
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (C1ACR_561)

<400>  95
atggagatca acaccaccag cccctacggc tggtgggccg ccgccaaccc cgagtgcgtg       60

gccaaggccg ccgtgaccgt ggacatccag atcttccagc tgtgctggtg catcatctgc      120

gcctgccagg ccttcttctt cgccatccgc taccccaagg tgacctggga gttcgtgctg      180

gtgcccctga ccgaggccgt gatctacggc ctgggctaca gcggcatcgg ctacgtggtg      240

ctgcagagcg gccgcaccgt ggcctggatg cgcatctgcc actggctgat caccgtgccc      300

gtgctgctgc tgcagatcag cgacgtggcc cacgtgcgct tccacggcgt gaacctgagc      360

agcctgcagg tgcccatcag cgtgctgatg atcgtgttcg gcttctgcgc cgaggtggcc      420

gacgaggagg gcgtgaagtg gatgttcttc gtgatcggcc tggtgctgat gttccaggtg      480

ctgttcgtgg gctaccacag cctgagccgc ggcatcaccc gcttcagcga ggccggcacc      540

gaggagggcg ccatggtggc caaccgcctg cgcgccatgc tggtgttctt cctgctgagc      600

tggaccctgc accccctgtt cttcgtgctg agcatcgagg gcgcctgcgt gatgaccgag      660

cccgtgaccg tggtgctgta catcgtgctg gacctgttcg ccaagaacat cttccagatc      720

gtgctgtggg acagcctgtg ggtgcgcctg accggcaagt ggaaggtgga ggagctggtg      780

gtgcacgacg ccagcgccga gctgggctac gacgaggact acaagcacga cgagatcaac      840

ctgagcatcg gcaacgtgcc cgtgagcacc gagagccccg tgccccgcgg cgccggcgag      900

ggcgcc                                                                 906


<210>  96
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (R2ACR_041)

<400>  96
atgggcctga ccgtgaccag caacaccaag gtgttccagc tgctgttcgc ctgcgtgtgc       60

gcctgccagg tgctgttcat ggccagccgc gccccccgcg tgacctggga ggccgtgtac      120

ctgcccctgg tggagaccat cctgtacgcc atggccgcca gcggcaacgg cagcatgcgc      180

ctggccgacg gccgcgtgat ccccatcggc cgcttctgca gctggctgat cacctgcccc      240

atcatgctgt tccaggtggt gggcatccac gagctgaagt ggagcggcgt gagctgcaag      300

aacatggtga tggccgccag cctgatccgc accgtgtacg gcatcggcgc cagcgtggtg      360

gccaacgaca tcatgaagtg ggtgctgtac gtgctgggct gcgtgtgcct ggccttcgag      420

ttcctggtgg tgcacagcat cttcagcgcc ggcctgaaga agttcgccgc cttccgcagc      480

accctgaacg acggcgtgta caaccgcctg ctgttcatgc gcgccctgtt cttcaccgcc      540

tggaccagct tccccgtgat ctgggtgctg gccagcaccg gcatctgcct gatcgacgag      600

aacgtgaccg tgctggccta cctgatcgcc gacatgctgt gcaagaacat gtacggcatc      660

atcaacgcca acaccctgtt ccgcgtgctg gacggcagct ggacccccga gaccctggag      720

accagcaaga acccccccaa gcacgaggtg cacgagacct acatcgacat ggccatgcac      780

cacatgcgcc ccagcaagag caagacccgc gaggccgcca tcgagctgga ggagcacacc      840

gccgacccct tcgccgaggg c                                                861


<210>  97
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic humanized rhodopsin (7 TM) domain (R2ACR_041)

<400>  97
atgggcctga ccgtgaccag caacaccaag gtgttccagc tgctgttcgc ctgcgtgtgc       60

gcctgccagg tgctgttcat ggccagcaga gcccccagag tgacctggga ggccgtgtac      120

ctgcccctgg tggagaccat cctgtacgcc atggccgcca gcggcaacgg cagcatgaga      180

ctggccgacg gcagagtgat ccccatcggc agattctgca gctggctgat cacctgcccc      240

atcatgctgt tccaggtggt gggcatccac gagctgaagt ggagcggcgt gagctgcaag      300

aacatggtga tggccgccag cctgatcaga accgtgtacg gcatcggcgc cagcgtggtg      360

gccaacgaca tcatgaagtg ggtgctgtac gtgctgggct gcgtgtgcct ggccttcgag      420

ttcctggtgg tgcacagcat cttcagcgcc ggcctgaaga agttcgccgc cttcagaagc      480

accctgaacg acggcgtgta caacagactg ctgttcatga gagccctgtt cttcaccgcc      540

tggaccagct tccccgtgat ctgggtgctg gccagcaccg gcatctgcct gatcgacgag      600

aacgtgaccg tgctggccta cctgatcgcc gacatgctgt gcaagaacat gtacggcatc      660

atcaacgcca acaccctgtt cagagtgctg gacggcagct ggacccccga gaccctggag      720

accagcaaga acccccccaa gcacgaggtg cacgagacct acatcgacat ggccatgcac      780

cacatgagac ccagcaagag caagaccaga gaggccgcca tcgagctgga ggagcacacc      840

gccgacccct tcgccgaggg c                                                861


<210>  98
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  98

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  99
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  99

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  100
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  100

Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu 
1               5                   10                  15      


Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln 
            20                  25      


<210>  101
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  101

Thr Lys Ile Glu Ser Leu Lys Glu His Gly 
1               5                   10  


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  102

Thr Gln Ile Glu Asn Leu Lys Glu Lys Gly 
1               5                   10  


<210>  103
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  103

Ala Ala Leu Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Glu Ala 
1               5                   10                  15      


Leu Glu Ala Leu Ala Glu Ala Ala Ala Ala 
            20                  25      


<210>  104
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  104

Gly Leu Phe Glu Ala Ile Glu Gly Phe Ile Glu Asn Gly Trp Glu Gly 
1               5                   10                  15      


Met Ile Glu Gly Trp Tyr Gly Cys Gly 
            20                  25  


<210>  105
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic rhodopsin C1ACR_023

<400>  105

Met Thr Val Leu Glu Val Asn Glu Ala Val Ile Ile Asp Gly Val Met 
1               5                   10                  15      


Tyr Gly Glu Tyr Ile Phe Ser His Pro Gln Cys Ile Pro Ala Glu Leu 
            20                  25                  30          


Val Pro Val Val Lys Val Phe Gln Ile Cys Trp Ala Val Val Ser Met 
        35                  40                  45              


Cys Gln Ser Ala Phe Met Met Thr Arg Met Pro Lys Val Pro Trp Glu 
    50                  55                  60                  


Ala Ile Tyr Leu Pro Met Val Glu Ala Ile Val Tyr Val Met Ala Tyr 
65                  70                  75                  80  


Thr Gly Asn Gly Tyr Leu Lys Met Gly Ser Gly Arg Val Leu Pro Trp 
                85                  90                  95      


Ala Arg Met Ala Ser Trp Leu Val Thr Cys Pro Val Met His Gly Gln 
            100                 105                 110         


Ile Ser Gly Met Thr Leu Ile Lys Tyr Gln Ser Ile Pro Ile Asn Pro 
        115                 120                 125             


Met Val Ile Ala Ala Ser Ile Ile Arg Val Val Met Gly Val Thr Ala 
    130                 135                 140                 


Thr Ile Val Val Thr Glu Asp Leu Lys Trp Ala Phe Phe Gly Cys Gly 
145                 150                 155                 160 


Leu Val Cys Leu Leu Phe Glu Tyr Ala Ser Val Tyr Thr Ile Phe Ala 
                165                 170                 175     


Val Thr Ile Gly Asp Phe Ala Asp Ala Lys Thr Asp Leu Gly Asn Gln 
            180                 185                 190         


Val Val Ala Arg Leu Lys Ser Ile Arg Ser Ile Phe Phe Val Ala Trp 
        195                 200                 205             


Thr Ala Phe Pro Ile Leu Trp Leu Leu Ser Ser Thr Gly Thr Cys Val 
    210                 215                 220                 


Ile Asp Glu Asn Ile Ser Ala Val Ala Tyr Leu Ile Ser Asp Ala Phe 
225                 230                 235                 240 


Cys Lys Asn Phe Asn Gly Ile Leu Leu Trp Ser Thr Thr Trp Gly Leu 
                245                 250                 255     


Leu Asn Gly Lys Trp Asp Arg Asp Phe Val Arg Ala Pro Pro Ala Ala 
            260                 265                 270         


Glu Ser Glu Lys Asp Val Gln Asp Ala Pro Arg Pro Lys Ser Asp Val 
        275                 280                 285             


Glu Val Lys Met Phe Gly Lys Val Ile Gly Ser Val Arg 
    290                 295                 300     


<210>  106
<211>  294
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic rhodopsin R1ACR_367

<400>  106

Met Ser Tyr Val Glu Asp Pro Ala Phe Gly Phe Tyr Gly Ser Trp Glu 
1               5                   10                  15      


Ala Ala Asn Gln Asp Cys Ile Glu Arg Gly Leu Ser Thr Thr Asn Asn 
            20                  25                  30          


Thr Arg Met Ile Gln Leu Leu Phe Ala Ser Ile Cys Ala Cys Gln Val 
        35                  40                  45              


Leu Phe Met Ala Ser Arg Ala Pro Arg Val Thr Trp Glu Ala Val Tyr 
    50                  55                  60                  


Leu Pro Val Val Glu Thr Val Leu Tyr Gly Met Ala Ser Thr Gly Asn 
65                  70                  75                  80  


Gly Ser Met Arg Leu Ala Asp Gly Arg Ile Val Pro Ile Ala Arg Phe 
                85                  90                  95      


Cys Ser Trp Leu Ile Thr Cys Pro Ile Met Leu Phe Gln Val Val Gly 
            100                 105                 110         


Ile His Glu Leu Lys Trp Arg Thr Ile Ser Cys Lys Asn Met Val Met 
        115                 120                 125             


Ala Ala Ser Leu Ile Arg Thr Val Phe Gly Ile Gly Ala Ser Val Thr 
    130                 135                 140                 


Ile Thr Pro Thr Met Arg Trp Val Gln Tyr Phe Leu Ser Leu Ser Phe 
145                 150                 155                 160 


Phe Leu Phe Glu Leu Ile Val Val Tyr Gln Ile Phe Ser Ala Gly Leu 
                165                 170                 175     


Lys Lys Phe Gly Ala Val Lys Thr Ser Leu Asn Asn Ile Val Tyr Ser 
            180                 185                 190         


Arg Ile Met Phe Leu Arg Phe Leu Phe Phe Leu Ser Trp Ser Ser Phe 
        195                 200                 205             


Pro Ile Ile Trp Leu Leu Ser Ser Thr Gly Phe Cys Leu Val Asn Glu 
    210                 215                 220                 


Asp Val Ser Val Leu Ala Tyr Leu Val Ala Asp Met Ile Cys Lys Asn 
225                 230                 235                 240 


Leu Tyr Gly Ile Thr Asn Ala Asn Thr Leu Phe Arg Val Leu Asn Gly 
                245                 250                 255     


Lys Trp Thr Pro Glu Thr Glu Glu Glu Ala Lys Gln Pro Lys Asp Asn 
            260                 265                 270         


Glu His Ala His Val Gly Glu Thr Tyr Phe Glu Gln Met Leu Ser Gly 
        275                 280                 285             


Leu Arg Gly Ser Arg His 
    290                 


<210>  107
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic rhodopsin GcACR_457

<400>  107

Met Ser Ala Cys Pro Pro Arg Thr Pro Arg Tyr Gly Asn Met Ser Ala 
1               5                   10                  15      


Ala Asp Lys Arg Ala Glu Tyr Leu Gln Lys Val Ile Asp Leu Ser Pro 
            20                  25                  30          


Glu Ile Tyr Gly Ser Tyr Ala Arg Asp Asn Ala Glu Cys Leu Ala Met 
        35                  40                  45              


Ser Val Val Thr Met Pro Phe Val Lys Ile Thr Gln Leu Cys Met Ala 
    50                  55                  60                  


Val Met Ser Ala Cys Gln Val Leu Phe Met Ile Ser Arg Ala Pro Arg 
65                  70                  75                  80  


Val Pro Trp Glu Ala Ile Tyr Leu Pro Ala Thr Glu Met Ile Ser Tyr 
                85                  90                  95      


Ser Leu Ala Phe Phe Gly Gln Gly Tyr Val Arg Leu Ala Asn Gly Lys 
            100                 105                 110         


Val Leu Pro Trp Cys Arg Met Ala Ala Trp Leu Cys Thr Cys Pro Ile 
        115                 120                 125             


Met Leu Gly Leu Val Ser Asn Met Ala Leu Ile Lys Tyr Lys Ser Gln 
    130                 135                 140                 


Pro Leu Asn Pro Met Met Ile Ala Ala Ser Ile Ile Arg Thr Val Phe 
145                 150                 155                 160 


Gly Ile Ser Ala Thr Met Ala Glu Thr Asn Asp Val Ile Trp Thr His 
                165                 170                 175     


Phe Phe Phe Ala Phe Val Cys Phe Ile Phe Glu Met Ser Cys Ala Phe 
            180                 185                 190         


Ala Ile Phe Ala Leu Thr Ile Asp Asp Phe Gln Gln Ile Gly Ser Pro 
        195                 200                 205             


Leu Ala Met Lys Val Val Lys Arg Leu Tyr Leu Leu Arg Met Val Phe 
    210                 215                 220                 


Phe Gly Thr Trp Ser Cys Phe Pro Ile Leu Trp Ile Ile Ser Ser Thr 
225                 230                 235                 240 


Tyr Met Cys Val Ile Asp Glu Asn Ala Ser Ala Leu Leu Tyr Leu Val 
                245                 250                 255     


Ala Asp Ile Ser Cys Lys Asn Cys Tyr Gly Leu Leu Leu Trp Ser Thr 
            260                 265                 270         


Thr Trp Gly Leu Leu Asn Gly Lys Trp Asp Arg Glu Tyr Ala Arg Asn 
        275                 280                 285             


Arg Asp Glu Ala Gly Met Leu Met Glu Thr Asp Glu Lys Gln Gly Val 
    290                 295                 300                 


Ile Glu Pro Pro Lys Glu Asn Phe Asp Val Lys Leu 
305                 310                 315     


<210>  108
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic rhodopsin GcACR_203

<400>  108

Met Ala Ala Arg Leu Ala Lys Val Val His Leu Ala Arg Leu Val Val 
1               5                   10                  15      


Leu Phe Ala Val Met Leu Asp Ala Gln Asp Thr Gly Ser Gln Ala Val 
            20                  25                  30          


Gly Phe Gln Pro Glu Glu Arg Met Val Val Arg Gly Lys Ala Ala Tyr 
        35                  40                  45              


Ile Asp Gly Ile Gly Pro Ala Thr Pro Tyr Ala Gly Met Tyr Gly Glu 
    50                  55                  60                  


Trp Glu Ile Ala Asn Pro Asp Cys Val Asn Lys Gly Leu His Ala Thr 
65                  70                  75                  80  


Ser Arg Glu Arg Thr Ile Ile Thr Leu Trp Ala Val Val Cys Leu Cys 
                85                  90                  95      


Gln Ala Leu Phe Met Met Thr Arg Ala Pro Lys Val Thr Trp Glu Ala 
            100                 105                 110         


Val Tyr Leu Pro Leu Val Glu Cys Ile Leu Tyr Cys Cys Thr Gly Ala 
        115                 120                 125             


Gly Tyr Gly Val Leu Arg Met Gly Asp Gly Arg Met Leu Pro Leu Ser 
    130                 135                 140                 


Arg Met Cys Ser Trp Leu Ile Thr Cys Pro Ile Met Leu Ser Gln Ala 
145                 150                 155                 160 


Phe Gly Ile His Asp Met Lys Leu Tyr Gly Ile Gln Leu Arg Met Pro 
                165                 170                 175     


Ile Cys Ala Ala Ser Leu Ile Arg Thr Val Cys Gly Leu Leu Ala Ser 
            180                 185                 190         


Thr Thr Thr Asp Thr Lys Ile Ala Lys Trp Leu Phe Phe Phe Leu Gly 
        195                 200                 205             


Phe Ser Phe Tyr Thr Met Glu Ile Thr Thr Val Trp Phe Ile Phe Gln 
    210                 215                 220                 


Gln Gly Ile Ala Lys Phe Thr Pro Thr Thr Asp Val Pro Glu Asn Ala 
225                 230                 235                 240 


Thr Ala Leu Arg Arg Leu Tyr Phe Met Arg Phe Ile Phe Phe Thr Ser 
                245                 250                 255     


Trp Thr Ala Phe Pro Val Phe Trp Val Leu Ser Ser Thr Gly Leu Cys 
            260                 265                 270         


Val Ile Ser Glu Gln Thr Ser Ala Leu Gly Tyr Leu Cys Ala Asp Ala 
        275                 280                 285             


Leu Cys Lys Asn Leu Tyr Gly Val Ile Gln Thr Asn Thr Val Trp Gly 
    290                 295                 300                 


Leu Leu Gly Gly Thr Trp Thr Pro Lys Lys His Pro Asn Asn His Asp 
305                 310                 315                 320 


Glu Glu Ala Pro Ala Asn Ser His Asn His Lys Glu Glu Asp Thr Phe 
                325                 330                 335     


Ala Ala Pro His Gly Arg Phe Asn Ser Ala Lys Glu Ile Glu Asp 
            340                 345                 350     


<210>  109
<211>  280
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic rhodopsin C1ACR_197

<400>  109

Met Gln Ala Ser Gln Ile Ser Ser Ser Tyr Phe Gly Gln Trp Ser Ala 
1               5                   10                  15      


Thr Asn Ile Asp Cys Val Ala Lys Ala Asp Ile Ser Ser Gly Val Gln 
            20                  25                  30          


Thr Phe Leu Leu Cys Phe Cys Ile Ile Ser Ala Cys Gln Ala Leu Tyr 
        35                  40                  45              


Phe Ser Tyr His Cys Leu Pro Gln Ala Gly Ala Arg Arg Arg Ser Thr 
    50                  55                  60                  


Trp Glu Phe Ile Ala Val Pro Ala Val Glu Ala Leu Cys Tyr Gly Leu 
65                  70                  75                  80  


Ala Ser Ser Ser Ser Gln Val Gly Tyr Phe Arg Leu Phe Asp Gly Arg 
                85                  90                  95      


Thr Val Val Trp Leu Arg Thr Val Leu Trp Ile Leu Thr Val Pro Val 
            100                 105                 110         


Leu Leu Leu Gln Ile Gly Lys Met Ser Tyr Val Val Ile Gln Gly Val 
        115                 120                 125             


Glu Val Asn Ser Leu Ile Ile Phe Val Gly Leu Leu Met Val Val Phe 
    130                 135                 140                 


Gly Phe Ser Ala Ser Leu Ser Thr Val Met Gly Ile Lys Trp Met Phe 
145                 150                 155                 160 


Phe Phe Phe Gly Leu Val Cys Met Ala Val Val Phe Leu Gly Val Tyr 
                165                 170                 175     


Lys Ile Met Val Asp Ala Gly Ser Tyr Tyr Ile Ser Leu Asn Ser Gln 
            180                 185                 190         


Asp Gly Leu Gln Ile Ala Ser Arg Ile Arg Ile Leu Met Ile Ile Phe 
        195                 200                 205             


Phe Phe Ser Trp Thr Ala Thr Pro Leu Phe Trp Val Leu Ser Ile Glu 
    210                 215                 220                 


Gly Ala Cys Val Val Ser Glu Ser Ile Thr Val Val Cys Phe Ala Val 
225                 230                 235                 240 


Ile Asp Ser Leu Ala Lys Asn Ile Phe Gly Ile Ile Leu Trp Asp Thr 
                245                 250                 255     


Val Trp Asn Ser Ser Leu Glu Gly Arg Trp Thr Ser Asn Leu Gln Ile 
            260                 265                 270         


Met Ala Thr Glu Met Ser Met Leu 
        275                 280 


<210>  110
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct R1ACR_741

<400>  110

Met Ser Tyr Val Glu Asp Pro Ala Phe Gly Phe Tyr Gly Ser Trp Glu 
1               5                   10                  15      


Ala Ala Asn Gln Asp Cys Ile Glu Arg Gly Leu Ser Thr Ser Asn Asn 
            20                  25                  30          


Thr Arg Met Ile Gln Leu Leu Phe Ala Ser Ile Cys Ala Cys Gln Val 
        35                  40                  45              


Leu Phe Met Ala Ser Arg Ala Pro Arg Val Thr Trp Glu Ala Val Tyr 
    50                  55                  60                  


Leu Pro Val Val Glu Thr Val Leu Tyr Gly Met Ala Ser Thr Gly Asn 
65                  70                  75                  80  


Gly Asn Met Arg Leu Ala Asp Gly Arg Ile Val Pro Ile Ala Arg Phe 
                85                  90                  95      


Cys Ser Trp Leu Ile Thr Cys Pro Ile Met Leu Phe Gln Val Val Gly 
            100                 105                 110         


Ile His Glu Leu Lys Trp Arg Thr Ile Ser Cys Lys Asn Met Val Met 
        115                 120                 125             


Ala Ala Ser Leu Ile Arg Thr Val Phe Gly Ile Gly Ala Ser Val Thr 
    130                 135                 140                 


Ile Thr Pro Thr Met Arg Trp Val Gln Tyr Phe Leu Ser Leu Ser Phe 
145                 150                 155                 160 


Phe Leu Phe Glu Leu Ile Val Val Tyr Gln Ile Phe Ser Ala Gly Leu 
                165                 170                 175     


Lys Lys Phe Gly Ala Val Lys Thr Ser Leu Asn Asn Ile Val Tyr Ser 
            180                 185                 190         


Arg Ile Met Phe Leu Arg Phe Leu Phe Phe Leu Ser Trp Ser Ser Phe 
        195                 200                 205             


Pro Ile Ile Trp Leu Leu Ser Ser Thr Gly Phe Cys Leu Val Asn Glu 
    210                 215                 220                 


Asp Val Ser Val Leu Ala Tyr Leu Val Ala Asp Met Ile Cys Lys Asn 
225                 230                 235                 240 


Leu Tyr Gly Ile Thr Asn Ala Asn Thr Leu Phe Arg Val Leu Asn Gly 
                245                 250                 255     


Lys Trp Thr Pro Glu Thr Glu Glu Glu Ala Met Leu Pro Lys Asp His 
            260                 265                 270         


Glu His Ala His Val Gly Glu Thr Tyr Phe Glu Gln Met Leu Ser Gly 
        275                 280                 285             


Leu Arg Gly Ser Arg Arg Arg Asp His 
    290                 295         


<210>  111
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct R1ACR_447

<400>  111

Met Val Trp Ser His Val Asp Glu Pro Ala Leu Gly Pro Tyr Gly Ser 
1               5                   10                  15      


Trp Glu Ala Ala Asn Pro Asp Cys Val Ala Leu Gly Leu Thr Thr Ser 
            20                  25                  30          


Lys Asn Thr Lys Met Ile Leu Leu Leu Phe Ala Ser Ile Cys Ala Cys 
        35                  40                  45              


Gln Val Leu Phe Met Ala Ser Arg Ala Pro Arg Ile Thr Trp Glu Ala 
    50                  55                  60                  


Val Tyr Leu Pro Leu Ile Glu Thr Ile Leu Tyr Ala Met Ala Ser Thr 
65                  70                  75                  80  


Gly Asn Gly Gln Leu Arg Leu Gly Asp Gly Arg Val Leu Pro Ile Ala 
                85                  90                  95      


Arg Tyr Cys Ser Trp Leu Ile Thr Cys Pro Ile Met Leu Phe Gln Val 
            100                 105                 110         


Val Gly Leu Tyr Asp Leu Lys Leu Trp Gly Ile Ser Cys Lys His Met 
        115                 120                 125             


Val Met Ala Ala Ala Leu Ile Arg Thr Val Phe Gly Ile Gly Ala Ser 
    130                 135                 140                 


Val Thr Leu Asp Asp Gln Met Arg Trp Val Gln Phe Phe Leu Ser Tyr 
145                 150                 155                 160 


Ala Phe Phe Phe Phe Glu Leu Tyr Cys Ala Tyr Met Ile Phe Gly Ala 
                165                 170                 175     


Ala Leu Lys Gln Phe Gly Glu Val Arg Thr Thr Leu Asn Ser Ile Val 
            180                 185                 190         


Tyr Ser Arg Ile Met Leu Leu Arg Phe Ile Phe Phe Leu Ser Trp Asn 
        195                 200                 205             


Ser Phe Gly Ile Ile Trp Leu Leu Ser Ser Thr Gly Leu Cys Met Ile 
    210                 215                 220                 


Ser Glu Asp Val Ser Val Leu Ala Tyr Leu Ala Ala Asp Met Leu Cys 
225                 230                 235                 240 


Lys Asn Thr Tyr Gly Ile Ile Asn Ala Asn Thr Leu Phe Arg Val Leu 
                245                 250                 255     


Asp Gly Lys Trp Thr Pro Glu Thr Leu Glu Glu Ala Ala Ser Gly Val 
            260                 265                 270         


Lys Lys Ala Asn Pro Asn His Val Gly Glu Thr Tyr Leu Glu Arg Met 
        275                 280                 285             


Met Ala Gly Ile Arg Gly Ser Ala Lys Pro Glu Glu 
    290                 295                 300 


<210>  112
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct R1ACR_877

<400>  112

Met Ser Ala Thr Glu Asn Pro Ala Phe Gly Leu Tyr Gly Thr Trp Glu 
1               5                   10                  15      


Asn Asp His Pro Gln Cys Val Glu Met Gly Leu Asp Thr Ser Ser Gln 
            20                  25                  30          


Thr Asn Met Ile His Leu Leu Phe Ala Ser Ile Cys Phe Cys Gln Val 
        35                  40                  45              


Leu Phe Met Ala Ser Arg Ala Pro Arg Val Thr Trp Glu Ala Val Tyr 
    50                  55                  60                  


Leu Pro Leu Val Glu Thr Val Leu Tyr Gly Met Ala Ala Ser Gly Asn 
65                  70                  75                  80  


Gly Asn Leu Arg Ile Ser Asn Gly Arg Met Val Pro Met Ala Arg Phe 
                85                  90                  95      


Cys Ser Trp Leu Ile Thr Cys Pro Ile Met Leu Leu Gln Val Val Val 
            100                 105                 110         


Met His Asp Val Val Trp Phe Asn Val Ser Thr Arg Tyr Met Val Leu 
        115                 120                 125             


Ala Ala Ser Leu Ile Arg Thr Val Phe Gly Ile Gly Ala Ser Val Thr 
    130                 135                 140                 


Thr Asn Asp Thr Met Arg Trp Val Gln Phe Leu Leu Ser Cys Ile Cys 
145                 150                 155                 160 


Phe Ala Phe Glu Met Val Val Ala His Gln Thr Tyr Lys Gly Ala Leu 
                165                 170                 175     


Lys Lys Phe Ala Ala Val Lys Thr Thr Leu Asn Gly Val Val Tyr Ala 
            180                 185                 190         


Arg Ile Met Phe Leu Arg Phe Leu Phe Phe Phe Ser Trp Asn Ala Phe 
        195                 200                 205             


Pro Ile Ile Trp Ala Leu Ser Ser Thr Gly Leu Cys Leu Ile Ser Glu 
    210                 215                 220                 


Asp Ala Ser Val Leu Ser Tyr Leu Val Ala Asp Leu Ile Cys Lys Asn 
225                 230                 235                 240 


Ile Tyr Gly Ile Thr Asn Ala Asn Thr Val Phe Arg Val Leu Asp Gly 
                245                 250                 255     


Ala Trp Val Pro Glu Thr Glu Glu His Ala Gln Ala Lys Asp His Leu 
            260                 265                 270         


Thr Tyr Leu Glu Met Met Met Asn His Asn Leu Gly Ile Gly Arg His 
        275                 280                 285             


His Asp Glu Glu Leu Gln Met Glu Val Gly His Asp 
    290                 295                 300 


<210>  113
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct R1ACR_995

<400>  113

Met Gly Ile Ala Ser Gly Ala Pro Val Lys Ile Ile Gln Leu Cys Trp 
1               5                   10                  15      


Ala Val Val Ser Leu Cys Gln Val Ile Phe Met Leu Thr Arg Ala Pro 
            20                  25                  30          


Arg Val Ala Trp Glu Ala Ile Tyr Leu Pro Leu Cys Glu Thr Ile Thr 
        35                  40                  45              


Tyr Phe Leu Ala Phe Thr Gly Asn Gly Tyr Leu Arg Met Ala Asp Gly 
    50                  55                  60                  


Gln Ile Phe Pro Trp Ala Arg Met Ala Ser Trp Leu Val Thr Cys Pro 
65                  70                  75                  80  


Val Met Leu Gly Gln Val Ser Ala Met Ala Leu Ile Lys Tyr Lys Ser 
                85                  90                  95      


Leu Pro Leu Asn Asn Met Met Val Ala Ala Ser Leu Ile Arg Val Val 
            100                 105                 110         


Met Gly Ile Ser Ala Thr Ile Thr Pro Asn Glu Gln Leu Lys Trp Met 
        115                 120                 125             


Phe Phe Phe Phe Gly Val Ser Met Leu Thr Phe Glu Tyr Phe Cys Val 
    130                 135                 140                 


Phe Thr Ile Phe Ser Ile Thr Ile Ala Asp Phe Gln Glu Ile Asp Thr 
145                 150                 155                 160 


Pro Arg Ser Arg Leu Val Val Gly Arg Leu Lys Ile Leu Arg Ile Val 
                165                 170                 175     


Phe His Ser Ala Trp Thr Ala Phe Pro Ile Leu Trp Val Val Ser Ser 
            180                 185                 190         


Thr Gly Leu Cys Val Leu Ser Glu Asn Ile Ser Ser Val Cys Tyr Met 
        195                 200                 205             


Leu Ala Asp Ala Ala Cys Lys Asn Gly Tyr Gly Leu Ile Leu Trp Asn 
    210                 215                 220                 


Thr Thr Trp Gly His Leu Asn Gly Lys Trp Asp Arg Glu Phe Ala Lys 
225                 230                 235                 240 


Asn Ala Asp Lys Asp Gly Glu Met Lys Ala Ile Glu Glu Gly Thr Ala 
                245                 250                 255     


Gly Pro Ala Ala Asp Ala Lys Lys Asp Glu Asp Ile Lys Leu Phe Gly 
            260                 265                 270         


Lys Pro Val 
        275 


<210>  114
<211>  297
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct R1ACR_477

<400>  114

Met Ala Leu Tyr Thr Ser Gln Phe Gly Ile Ala Tyr Gly Ser Trp Glu 
1               5                   10                  15      


Ala Glu Asn Asp Asp Cys Leu Ser Met Gly Ile Ala Ser Gly Ala Pro 
            20                  25                  30          


Val Lys Ile Ile Gln Leu Cys Trp Ala Val Val Ser Leu Cys Gln Val 
        35                  40                  45              


Ile Phe Met Leu Thr Arg Ala Pro Arg Val Ala Trp Glu Ala Ile Tyr 
    50                  55                  60                  


Leu Pro Leu Cys Glu Thr Ile Thr Tyr Phe Leu Ala Phe Ser Gly Asn 
65                  70                  75                  80  


Gly Tyr Leu Arg Met Ala Asp Gly Gln Ile Phe Pro Trp Ala Arg Met 
                85                  90                  95      


Ala Ser Trp Leu Val Thr Cys Pro Val Met Leu Gly Gln Val Ser Ala 
            100                 105                 110         


Met Ala Leu Ile Lys Tyr Lys Ser Leu Pro Leu Asn Asn Met Met Val 
        115                 120                 125             


Ala Ala Ser Leu Ile Arg Val Val Met Gly Ile Ser Ala Thr Ile Thr 
    130                 135                 140                 


Pro Asn Glu Gln Leu Lys Trp Met Phe Phe Phe Phe Gly Val Ser Met 
145                 150                 155                 160 


Leu Thr Phe Glu Tyr Phe Cys Val Phe Thr Ile Phe Ser Ile Thr Ile 
                165                 170                 175     


Ala Asp Phe Gln Glu Ile Asp Thr Pro Arg Ser Arg Phe Val Val Gly 
            180                 185                 190         


Arg Leu Lys Ile Leu Arg Ile Val Phe His Ser Ala Trp Thr Ala Phe 
        195                 200                 205             


Pro Ile Leu Trp Val Val Ser Ser Thr Gly Leu Cys Val Leu Ser Glu 
    210                 215                 220                 


Asn Ile Ser Ser Val Cys Tyr Met Leu Ala Asp Ala Ala Cys Lys Asn 
225                 230                 235                 240 


Gly Tyr Gly Leu Val Leu Trp Asn Thr Thr Trp Gly His Leu Asn Gly 
                245                 250                 255     


Lys Trp Asp Arg Glu Phe Ala Lys Asn Ala Asp Lys Asp Gly Glu Met 
            260                 265                 270         


Lys Ala Ile Glu Glu Gly Ala Ala Gly Pro Ala Ala Asp Ala Lys Lys 
        275                 280                 285             


Asp Glu Asp Ile Lys Leu Phe Gly Lys 
    290                 295         


<210>  115
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct R1ACR_433

<400>  115

Met Ala Glu Leu Val Asp Glu Tyr Gly Leu Trp Ala Leu Glu Asn Pro 
1               5                   10                  15      


Glu Cys Met Glu Met Ser Tyr Thr Ser Pro Asn Thr Lys Thr Ala Gln 
            20                  25                  30          


Leu Cys Phe Cys Met Val Cys Leu Cys Gln Ile Ile Trp Ile Met Gly 
        35                  40                  45              


Gln Trp Pro Lys Val Gly Trp Glu Ser Ile Tyr Leu Pro Ala Cys Glu 
    50                  55                  60                  


Met Thr Leu Tyr Ser Leu Ala Ala Ser Gly Asn Gly Phe Ile Gln Leu 
65                  70                  75                  80  


Ala Asp Gly Arg Ile Ile Pro Tyr Ala Arg Met Ala Ala Trp Ile Cys 
                85                  90                  95      


Thr Cys Pro Ala Leu Leu Met Gln Ile Asn Gly Leu Ala Lys Cys Lys 
            100                 105                 110         


Leu Gly His Phe Asn Leu Asn Thr Phe Gln Val Val Ala Asp Leu Ile 
        115                 120                 125             


Met Asn Val Met Gly Leu Asn Ala Thr Leu Thr Asn His Thr Tyr Leu 
    130                 135                 140                 


Lys Trp Ile Tyr Phe Gly Ile Ala Met Val Leu Phe Gly Cys Ile Met 
145                 150                 155                 160 


Gly Ile Thr His Asp Ile Phe Ser Gln Thr Ala Arg Lys Trp Lys Ser 
                165                 170                 175     


Val Asp Thr Pro Leu Ala Gln Lys Val Ala Trp Arg Val Thr Phe Leu 
            180                 185                 190         


Lys Tyr Leu Phe Ser Leu Ser Trp Ser Ile Tyr Pro Leu Leu Trp Ile 
        195                 200                 205             


Leu Ser Pro Gln Ala Thr Cys Ser Leu Arg Glu Asp Val Ile Ser Cys 
    210                 215                 220                 


Leu His Phe Val Ser Asp Phe Phe Ala Lys Asn Ile Phe Gly Leu Val 
225                 230                 235                 240 


Met Trp Trp Thr Leu Trp Arg Asp Leu Asp Gly Asp Trp Ser Phe Glu 
                245                 250                 255     


His His Tyr Pro Pro Asp Gln Glu Gln Ala Arg Ser Ser Ala Ser Ala 
            260                 265                 270         


Thr His Ser Leu Pro Gly Lys Ser Ile Gly Leu Ala Glu Ser Ile Asn 
        275                 280                 285             


Phe Val Lys Asp Thr Gln Asp Cys His Asp His Asp Gly 
    290                 295                 300     


<210>  116
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct R1ACR_973

<400>  116

Met Ala Ala Leu His Gln Ala Leu Glu Glu Leu Gly Gln Gly Ala Ser 
1               5                   10                  15      


Arg His Leu Leu Tyr Arg Ala Pro Glu Glu Met Val Tyr Gly Lys Trp 
            20                  25                  30          


Val Glu Ala Asn Pro Arg Cys Ile Glu Leu His Asp His Ser Asp Tyr 
        35                  40                  45              


Val Tyr Val Phe Gln Leu Cys Phe Ala Val Val Cys Ala Cys Gln Val 
    50                  55                  60                  


Ile Phe Met Phe Thr Arg Ala Pro Asn Val Gly Trp Glu Ala Ile Tyr 
65                  70                  75                  80  


Leu Pro Leu Ala Glu Val Val Thr Tyr Ser Ile Ala Ala Asn Gly Glu 
                85                  90                  95      


Gly Val Leu Arg Met Ala Asp Gly Arg Tyr Phe Asn Phe Ala Lys Leu 
            100                 105                 110         


Ala Gly Trp Ala Val Cys Cys Pro Ile Met Leu Ile Gln Ile Gly Gly 
        115                 120                 125             


Met Ala Gln Ile Lys Tyr Arg Thr Ile Pro Leu Asn Asn Val Val Leu 
    130                 135                 140                 


Ala Ala Ser Leu Asn Arg Ile Ile Phe Gly Met Ala Ser Ala Ile Thr 
145                 150                 155                 160 


Ala Ser Asp Pro Ala Arg Trp Gly Phe Tyr Phe Cys Ala Trp Ile Cys 
                165                 170                 175     


Tyr Leu Thr Glu Val Gly Ile Thr Leu Thr Ile Met Ala Val Ala Ile 
            180                 185                 190         


Ser Asp Phe Ser Lys Ile Lys Thr Glu Leu Gly Gln Trp Val Val Gly 
        195                 200                 205             


Arg Ile Gln Thr Met Arg Ile Ile Phe Leu Val Ala Trp Thr Ser Phe 
    210                 215                 220                 


Pro Val Val Trp Val Leu Gly Tyr Thr Gly Phe Cys Val Ile His Glu 
225                 230                 235                 240 


Asp Tyr Ile Ala Leu Leu Tyr Leu Phe Ala Asp Leu Leu Ser Lys Asn 
                245                 250                 255     


Thr Trp Gly Val Met Met Trp His Thr Thr Trp Val Lys Leu Asn Gly 
            260                 265                 270         


Lys Trp Asp Arg Glu Phe Ala Ala Ala Gly Gly His Glu Ala Leu Lys 
        275                 280                 285             


Lys Ala Leu Glu Gln Asp Val Glu Ile Gly Ala Gly Glu Lys Asn Gln 
    290                 295                 300                 


Asn Gln Leu Thr Ala Arg Gln 
305                 310     


<210>  117
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct R1ACR_243

<400>  117

Met Ile Ile Thr Leu Trp Ala Val Val Cys Met Cys Gln Ala Leu Phe 
1               5                   10                  15      


Met Met Thr Arg Ala Pro Lys Val Thr Trp Glu Ala Val Tyr Leu Pro 
            20                  25                  30          


Leu Val Glu Cys Ile Leu Tyr Cys Cys Thr Gly Ala Gly Tyr Gly Gln 
        35                  40                  45              


Leu Arg Met Gly Asp Gly Arg Met Leu Pro Leu Ser Arg Met Cys Ser 
    50                  55                  60                  


Trp Leu Ile Thr Cys Pro Ile Met Leu Ser Gln Ala Phe Gly Ile His 
65                  70                  75                  80  


Asp Leu Lys Leu Tyr Gly Ile Gln Met Arg Met Pro Ile Leu Ala Ala 
                85                  90                  95      


Ser Leu Ile Arg Ser Val Cys Gly Leu Leu Ala Ser Thr Thr Thr Asp 
            100                 105                 110         


Thr Lys Val Val Lys Trp Phe Phe Phe Phe Leu Gly Phe Cys Phe Phe 
        115                 120                 125             


Ser Met Glu Ile Gly Ser Val Trp Phe Ile Phe Gln His Gly Ile Ala 
    130                 135                 140                 


Lys Phe Ala Pro Thr Thr Asp Val Pro Glu Asn Ala Thr Ala Leu Asn 
145                 150                 155                 160 


Arg Leu Tyr Ile Met Arg Val Ile Phe Phe Ser Ser Trp Thr Ala Phe 
                165                 170                 175     


Pro Leu Phe Trp Val Leu Ser Ser Thr Gly Leu Cys Val Ile Ser Glu 
            180                 185                 190         


Gln Thr Ser Ala Leu Gly Tyr Leu Cys Ala Asp Ala Phe Cys Lys Asn 
        195                 200                 205             


Leu Tyr Gly Val Ile Gln Thr Asn Thr Val Trp Gly Val Leu Gly Gly 
    210                 215                 220                 


Thr Trp Thr Pro Lys Lys Pro Pro Ser Lys Asp Asp Glu Glu Ala Pro 
225                 230                 235                 240 


Thr Asn Ser His Asn Asp Lys Glu Met Asp Ala Phe Thr Ala Pro His 
                245                 250                 255     


Gly Arg Phe Asn Ser Ala Lys Glu Ile Gln Asp Thr Tyr Asn Ser Asp 
            260                 265                 270         


Thr Tyr Phe Ile Arg Ala Ala Lys Ala Val Ser Val Arg Met Ser Arg 
        275                 280                 285             


Lys Lys Gly 
    290     


<210>  118
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct R1ACR_439

<400>  118

Met Ala Glu Thr Gly Val Ile Arg Ser Gln Glu Asp Tyr Tyr Arg Leu 
1               5                   10                  15      


Val Glu Asn Arg Glu Thr Ile Gly Thr Tyr Trp Asp Ser Ser Leu Val 
            20                  25                  30          


Tyr Gly Glu Trp Ala Arg Asn Asn Gly Asn Cys Leu Arg Gln Ser Glu 
        35                  40                  45              


Val Asp Val Gln Phe Val Lys Ile Leu Gln Leu Cys Met Ser Val Val 
    50                  55                  60                  


Ser Ser Cys Gln Val Leu Phe Met Val Ser Arg Ala Pro Leu Val Pro 
65                  70                  75                  80  


Trp Glu Ala Ile Tyr Leu Pro Met Thr Glu Ser Ile Thr Tyr Gly Leu 
                85                  90                  95      


Ala Phe Thr Gly Asn Gly Tyr Ile Arg Leu Ala Thr Gly Lys Ile Leu 
            100                 105                 110         


Pro Trp Ala Arg Met Ala Ser Trp Leu Cys Thr Cys Pro Ile Met Leu 
        115                 120                 125             


Gly Met Val Ser Asn Met Ala Leu Val Lys Tyr Lys Ser Gln Pro Leu 
    130                 135                 140                 


Asn Pro Leu Met Val Ala Ser Ser Ile Ile Arg Val Val Phe Gly Ile 
145                 150                 155                 160 


Ser Ala Thr Met Ser Asp Asp Ser Gln Pro Ala Lys Trp Val Phe Phe 
                165                 170                 175     


Phe Ile Ala Val Ile Phe Phe Leu Phe Glu Leu Thr Cys Val Tyr Ala 
            180                 185                 190         


Ile Phe Gly Met Thr Ile Ala Asp Phe Ala Gln Ile Gln Ser Pro Leu 
        195                 200                 205             


Gly Asp Ala Val Val Tyr Arg Leu Asn Ile Leu Arg Gly Ile Phe Phe 
    210                 215                 220                 


Ala Ser Trp Thr Cys Phe Pro Ile Leu Trp Leu Val Ser Ser Thr Ser 
225                 230                 235                 240 


Ala Cys Leu Leu Asp Glu Asn Ile Ser Ala Val Leu Tyr Leu Met Ala 
                245                 250                 255     


Asp Ala Leu Cys Lys Asn Ser Tyr Gly Ile Val Leu Trp Ser Thr Thr 
            260                 265                 270         


Trp Gly Leu Leu Asn Gly Lys Trp Asp Arg Glu Tyr Pro Arg Asn Arg 
        275                 280                 285             


Asp Ile Asp Gly Leu Met Met Asp Ile Asp Pro Ala Lys Glu Lys Gln 
    290                 295                 300                 


Leu Glu Glu Met Pro Asn Gln Asn Phe Asp Ile Lys Ile Met Gly Gln 
305                 310                 315                 320 


Thr Ile Ala Ser Val Lys Arg Ser Cys Arg Arg Pro Arg Ala Asp Met 
                325                 330                 335     


Glu Ser Gln Asp 
            340 


