                         SEQUENCE LISTING

<110>  aratinga.bio AIO
 
<120>  Viral Vector Constructs for Expression of Genetic Adjuvants 
       Activating the STING Pathway

<130>  21062-6

<140>  PCT/IB2017/001540
<141>  2017-11-28

<150>  US 62/426,855
<151>  2016-11-28

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  2193
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus with IPS1 of Homo sapiens

<400>  1
atggatctgg atctcgaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggcatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg cctttcgccg aggacaagac ctacaagtac      600

atctgccgga acttcagcaa cttctgcaac gtggacgtgg tggaaattct gccctacctg      660

ccttgcctga ccgccagaga tcaggacaga ctgagagcca catgtaccct gagcggcaac      720

agagacacac tgtggcacct gttcaacacc ctgcagagaa ggcctggctg ggtcgagtac      780

tttatcgccg ctctgagagg ctgcgagctg gtcgatctgg ctgatgaagt ggccagcgtg      840

taccagagct accagcctag aaccagcgac cggcctcctg atcctctcga acctccatct      900

ctgcccgccg aaagacctgg acctcctaca ccagctgccg ctcacagcat cccttacaac      960

agctgcagag agaaagaacc tagctacccc atgcctgtgc aagagacaca ggccccagaa     1020

agccctggcg agaatagcga acaggctctg cagacactga gccccagagc cattcctaga     1080

aaccctgatg gcggccctct ggaaagctct agtgatctgg ccgctctgtc ccctctgaca     1140

agctctggac accaagagca ggataccgag ctgggcagca cacatacagc cggcgctaca     1200

agcagcctga caccttctag aggccccgtg tctcccagcg tgtcatttca gcctctggcc     1260

aggtctaccc ctagggcttc tagactgcct ggaccaacag gcagcgtggt gtctaccggc     1320

acaagcttca gctctagctc tcctggactg gctagtgccg gtgccgctga gggaaaacaa     1380

ggcgccgaat ctgatcaggc cgagcctatc atctgtagca gcggagcaga agcccctgcc     1440

aatagcctgc ctagcaaggt gccaaccaca ctgatgcccg tgaacacagt ggccctgaag     1500

gtgccagcta atcctgcctc cgtgtccacc gtgccttcta agctgccaac cagctctaag     1560

ccacctggcg ccgtgccatc taacgccctg acaaatcctg ctccaagcaa gctgcccatc     1620

aactccacaa gagccggcat ggtgccctct aaggtgccca catctatggt gctgaccaag     1680

gtgtccgcca gcaccgtgcc aacagatggc agctccagaa acgaggaaac ccctgccgct     1740

cctactcctg ctggcgctac aggcggatct tctgcttggc tggatagcag cagcgagaac     1800

agaggcctgg gcagcgagct ttctaaacct ggcgtgctgg cttcccaggt ggacagccca     1860

ttttccggct gctttgagga cctggctatc agcgcctcta caagcctcgg catgggacct     1920

tgtcacggcc ccgaggaaaa cgagtacaag agcgagggca ccttcggcat ccacgtggcc     1980

gagaatccta gcatccaact gctggaaggc aaccccggac ctccagctga tccagatggc     2040

ggaccaagac ctcaggccga cagaaagttc caagagcgcg aggtgccctg ccacagacct     2100

tctccaggtg ctctgtggct gcaggttgca gtgacaggcg tcctggtggt tacactgctc     2160

gtggtcctgt atagacggcg gctgcactga tga                                  2193


<210>  2
<211>  729
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus with IPS1 of Homo sapiens

<400>  2

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg Pro Phe 
            180                 185                 190         


Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe Ser Asn Phe 
        195                 200                 205             


Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro Cys Leu Thr 
    210                 215                 220                 


Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu Ser Gly Asn 
225                 230                 235                 240 


Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg Arg Pro Gly 
                245                 250                 255     


Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu Leu Val Asp 
            260                 265                 270         


Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln Pro Arg Thr 
        275                 280                 285             


Ser Asp Arg Pro Pro Asp Pro Leu Glu Pro Pro Ser Leu Pro Ala Glu 
    290                 295                 300                 


Arg Pro Gly Pro Pro Thr Pro Ala Ala Ala His Ser Ile Pro Tyr Asn 
305                 310                 315                 320 


Ser Cys Arg Glu Lys Glu Pro Ser Tyr Pro Met Pro Val Gln Glu Thr 
                325                 330                 335     


Gln Ala Pro Glu Ser Pro Gly Glu Asn Ser Glu Gln Ala Leu Gln Thr 
            340                 345                 350         


Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly Pro Leu Glu 
        355                 360                 365             


Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser Ser Gly His 
    370                 375                 380                 


Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr Ala Gly Ala Thr 
385                 390                 395                 400 


Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro Ser Val Ser Phe 
                405                 410                 415     


Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu Pro Gly Pro 
            420                 425                 430         


Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser Ser Ser Ser Pro 
        435                 440                 445             


Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly Ala Glu Ser 
    450                 455                 460                 


Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu Ala Pro Ala 
465                 470                 475                 480 


Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met Pro Val Asn Thr 
                485                 490                 495     


Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val Ser Thr Val Pro 
            500                 505                 510         


Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala Val Pro Ser Asn 
        515                 520                 525             


Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn Ser Thr Arg 
    530                 535                 540                 


Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met Val Leu Thr Lys 
545                 550                 555                 560 


Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser Arg Asn Glu Glu 
                565                 570                 575     


Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly Ser Ser Ala 
            580                 585                 590         


Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser Glu Leu Ser 
        595                 600                 605             


Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro Phe Ser Gly Cys 
    610                 615                 620                 


Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly Met Gly Pro 
625                 630                 635                 640 


Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly Thr Phe Gly 
                645                 650                 655     


Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu Gly Asn Pro 
            660                 665                 670         


Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln Ala Asp Arg 
        675                 680                 685             


Lys Phe Gln Glu Arg Glu Val Pro Cys His Arg Pro Ser Pro Gly Ala 
    690                 695                 700                 


Leu Trp Leu Gln Val Ala Val Thr Gly Val Leu Val Val Thr Leu Leu 
705                 710                 715                 720 


Val Val Leu Tyr Arg Arg Arg Leu His 
                725                 


<210>  3
<211>  2106
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus with IPS1 of Homo sapiens

<400>  3
atggatctgg atctcgaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggcatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg cctttcgccg aggacaagac ctacaagtac      600

atctgccgga acttcagcaa cttctgcaac gtggacgtgg tggaaattct gccctacctg      660

ccttgcctga ccgccagaga tcaggacaga ctgagagcca catgtaccct gagcggcaac      720

agagacacac tgtggcacct gttcaacacc ctgcagagaa ggcctggctg ggtcgagtac      780

tttatcgccg ctctgagagg ctgcgagctg gtcgatctgg ctgatgaagt ggccagcgtg      840

taccagagct accagcctag aaccagcgac cggcctcctg atcctctcga acctccatct      900

ctgcccgccg aaagacctgg acctcctaca ccagctgccg ctcacagcat cccttacaac      960

agctgcagag agaaagaacc tagctacccc atgcctgtgc aagagacaca ggccccagaa     1020

agccctggcg agaatagcga acaggctctg cagacactga gccccagagc cattcctaga     1080

aaccctgatg gcggccctct ggaaagctct agtgatctgg ccgctctgtc ccctctgaca     1140

agctctggac accaagagca ggataccgag ctgggcagca cacatacagc cggcgctaca     1200

agcagcctga caccttctag aggccccgtg tctcccagcg tgtcatttca gcctctggcc     1260

aggtctaccc ctagggcttc tagactgcct ggaccaacag gcagcgtggt gtctaccggc     1320

acaagcttca gctctagctc tcctggactg gctagtgccg gtgccgctga gggaaaacaa     1380

ggcgccgaat ctgatcaggc cgagcctatc atctgtagca gcggagcaga agcccctgcc     1440

aatagcctgc ctagcaaggt gccaaccaca ctgatgcccg tgaacacagt ggccctgaag     1500

gtgccagcta atcctgcctc cgtgtccacc gtgccttcta agctgccaac cagctctaag     1560

ccacctggcg ccgtgccatc taacgccctg acaaatcctg ctccaagcaa gctgcccatc     1620

aactccacaa gagccggcat ggtgccctct aaggtgccca catctatggt gctgaccaag     1680

gtgtccgcca gcaccgtgcc aacagatggc agctccagaa acgaggaaac ccctgccgct     1740

cctactcctg ctggcgctac aggcggatct tctgcttggc tggatagcag cagcgagaac     1800

agaggcctgg gcagcgagct ttctaaacct ggcgtgctgg cttcccaggt ggacagccca     1860

ttttccggct gctttgagga cctggctatc agcgcctcta caagcctcgg catgggacct     1920

tgtcacggcc ccgaggaaaa cgagtacaag agcgagggca ccttcggcat ccacgtggcc     1980

gagaatccta gcatccaact gctggaaggc aaccccggac ctccagctga tccagatggc     2040

ggaccaagac ctcaggccga cagaaagttc caagagcgcg aggtgccctg ccacagacct     2100

tctcca                                                                2106


<210>  4
<211>  702
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus with IPS1 of Homo sapiens

<400>  4

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg Pro Phe 
            180                 185                 190         


Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe Ser Asn Phe 
        195                 200                 205             


Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro Cys Leu Thr 
    210                 215                 220                 


Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu Ser Gly Asn 
225                 230                 235                 240 


Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg Arg Pro Gly 
                245                 250                 255     


Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu Leu Val Asp 
            260                 265                 270         


Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln Pro Arg Thr 
        275                 280                 285             


Ser Asp Arg Pro Pro Asp Pro Leu Glu Pro Pro Ser Leu Pro Ala Glu 
    290                 295                 300                 


Arg Pro Gly Pro Pro Thr Pro Ala Ala Ala His Ser Ile Pro Tyr Asn 
305                 310                 315                 320 


Ser Cys Arg Glu Lys Glu Pro Ser Tyr Pro Met Pro Val Gln Glu Thr 
                325                 330                 335     


Gln Ala Pro Glu Ser Pro Gly Glu Asn Ser Glu Gln Ala Leu Gln Thr 
            340                 345                 350         


Leu Ser Pro Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly Pro Leu Glu 
        355                 360                 365             


Ser Ser Ser Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser Ser Gly His 
    370                 375                 380                 


Gln Glu Gln Asp Thr Glu Leu Gly Ser Thr His Thr Ala Gly Ala Thr 
385                 390                 395                 400 


Ser Ser Leu Thr Pro Ser Arg Gly Pro Val Ser Pro Ser Val Ser Phe 
                405                 410                 415     


Gln Pro Leu Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu Pro Gly Pro 
            420                 425                 430         


Thr Gly Ser Val Val Ser Thr Gly Thr Ser Phe Ser Ser Ser Ser Pro 
        435                 440                 445             


Gly Leu Ala Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly Ala Glu Ser 
    450                 455                 460                 


Asp Gln Ala Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu Ala Pro Ala 
465                 470                 475                 480 


Asn Ser Leu Pro Ser Lys Val Pro Thr Thr Leu Met Pro Val Asn Thr 
                485                 490                 495     


Val Ala Leu Lys Val Pro Ala Asn Pro Ala Ser Val Ser Thr Val Pro 
            500                 505                 510         


Ser Lys Leu Pro Thr Ser Ser Lys Pro Pro Gly Ala Val Pro Ser Asn 
        515                 520                 525             


Ala Leu Thr Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn Ser Thr Arg 
    530                 535                 540                 


Ala Gly Met Val Pro Ser Lys Val Pro Thr Ser Met Val Leu Thr Lys 
545                 550                 555                 560 


Val Ser Ala Ser Thr Val Pro Thr Asp Gly Ser Ser Arg Asn Glu Glu 
                565                 570                 575     


Thr Pro Ala Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly Ser Ser Ala 
            580                 585                 590         


Trp Leu Asp Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser Glu Leu Ser 
        595                 600                 605             


Lys Pro Gly Val Leu Ala Ser Gln Val Asp Ser Pro Phe Ser Gly Cys 
    610                 615                 620                 


Phe Glu Asp Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly Met Gly Pro 
625                 630                 635                 640 


Cys His Gly Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly Thr Phe Gly 
                645                 650                 655     


Ile His Val Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu Gly Asn Pro 
            660                 665                 670         


Gly Pro Pro Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln Ala Asp Arg 
        675                 680                 685             


Lys Phe Gln Glu Arg Glu Val Pro Cys His Arg Pro Ser Pro 
    690                 695                 700         


<210>  5
<211>  1953
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus with IPS1 of Homo sapiens

<400>  5
atggatctgg atctcgaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggcatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg cctttcgccg aggacaagac ctacaagtac      600

atctgccgga acttcagcaa cttctgcaac gtggacgtgg tggaaattct gccctacctg      660

ccttgcctga ccgccagaga tcaggacaga ctgagagcca catgtaccct gagcggcaac      720

agagacacac tgtggcacct gttcaacacc ctgcagagaa ggcctggctg ggtcgagtac      780

tttatcgccg ctctgagagg ctgcgagctg gtcgatctgg ctgatgaagt ggccagcgtg      840

taccagagct accagcctag aaccagcgac cggggcgaga atagcgaaca ggctctgcag      900

acactgagcc ccagagccat tcctagaaac cctgatggcg gccctctgga aagctctagt      960

gatctggccg ctctgtcccc tctgacaagc tctggacacc aagagcagga taccgagctg     1020

ggcagcacac atacagccgg cgctacaagc agcctgacac cttctagagg ccccgtgtct     1080

cccagcgtgt catttcagcc tctggccagg tctaccccta gggcttctag actgcctgga     1140

ccaacaggca gcgtggtgtc taccggcaca agcttcagct ctagctctcc tggactggct     1200

agtgccggtg ccgctgaggg aaaacaaggc gccgaatctg atcaggccga gcctatcatc     1260

tgtagcagcg gagcagaagc ccctgccaat agcctgccta gcaaggtgcc aaccacactg     1320

atgcccgtga acacagtggc cctgaaggtg ccagctaatc ctgcctccgt gtccaccgtg     1380

ccttctaagc tgccaaccag ctctaagcca cctggcgccg tgccatctaa cgccctgaca     1440

aatcctgctc caagcaagct gcccatcaac tccacaagag ccggcatggt gccctctaag     1500

gtgcccacat ctatggtgct gaccaaggtg tccgccagca ccgtgccaac agatggcagc     1560

tccagaaacg aggaaacccc tgccgctcct actcctgctg gcgctacagg cggatcttct     1620

gcttggctgg atagcagcag cgagaacaga ggcctgggca gcgagctttc taaacctggc     1680

gtgctggctt cccaggtgga cagcccattt tccggctgct ttgaggacct ggctatcagc     1740

gcctctacaa gcctcggcat gggaccttgt cacggccccg aggaaaacga gtacaagagc     1800

gagggcacct tcggcatcca cgtggccgag aatcctagca tccaactgct ggaaggcaac     1860

cccggacctc cagctgatcc agatggcgga ccaagacctc aggccgacag aaagttccaa     1920

gagcgcgagg tgccctgcca cagaccttct cca                                  1953


<210>  6
<211>  651
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  6

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg Pro Phe 
            180                 185                 190         


Ala Glu Asp Lys Thr Tyr Lys Tyr Ile Cys Arg Asn Phe Ser Asn Phe 
        195                 200                 205             


Cys Asn Val Asp Val Val Glu Ile Leu Pro Tyr Leu Pro Cys Leu Thr 
    210                 215                 220                 


Ala Arg Asp Gln Asp Arg Leu Arg Ala Thr Cys Thr Leu Ser Gly Asn 
225                 230                 235                 240 


Arg Asp Thr Leu Trp His Leu Phe Asn Thr Leu Gln Arg Arg Pro Gly 
                245                 250                 255     


Trp Val Glu Tyr Phe Ile Ala Ala Leu Arg Gly Cys Glu Leu Val Asp 
            260                 265                 270         


Leu Ala Asp Glu Val Ala Ser Val Tyr Gln Ser Tyr Gln Pro Arg Thr 
        275                 280                 285             


Ser Asp Arg Gly Glu Asn Ser Glu Gln Ala Leu Gln Thr Leu Ser Pro 
    290                 295                 300                 


Arg Ala Ile Pro Arg Asn Pro Asp Gly Gly Pro Leu Glu Ser Ser Ser 
305                 310                 315                 320 


Asp Leu Ala Ala Leu Ser Pro Leu Thr Ser Ser Gly His Gln Glu Gln 
                325                 330                 335     


Asp Thr Glu Leu Gly Ser Thr His Thr Ala Gly Ala Thr Ser Ser Leu 
            340                 345                 350         


Thr Pro Ser Arg Gly Pro Val Ser Pro Ser Val Ser Phe Gln Pro Leu 
        355                 360                 365             


Ala Arg Ser Thr Pro Arg Ala Ser Arg Leu Pro Gly Pro Thr Gly Ser 
    370                 375                 380                 


Val Val Ser Thr Gly Thr Ser Phe Ser Ser Ser Ser Pro Gly Leu Ala 
385                 390                 395                 400 


Ser Ala Gly Ala Ala Glu Gly Lys Gln Gly Ala Glu Ser Asp Gln Ala 
                405                 410                 415     


Glu Pro Ile Ile Cys Ser Ser Gly Ala Glu Ala Pro Ala Asn Ser Leu 
            420                 425                 430         


Pro Ser Lys Val Pro Thr Thr Leu Met Pro Val Asn Thr Val Ala Leu 
        435                 440                 445             


Lys Val Pro Ala Asn Pro Ala Ser Val Ser Thr Val Pro Ser Lys Leu 
    450                 455                 460                 


Pro Thr Ser Ser Lys Pro Pro Gly Ala Val Pro Ser Asn Ala Leu Thr 
465                 470                 475                 480 


Asn Pro Ala Pro Ser Lys Leu Pro Ile Asn Ser Thr Arg Ala Gly Met 
                485                 490                 495     


Val Pro Ser Lys Val Pro Thr Ser Met Val Leu Thr Lys Val Ser Ala 
            500                 505                 510         


Ser Thr Val Pro Thr Asp Gly Ser Ser Arg Asn Glu Glu Thr Pro Ala 
        515                 520                 525             


Ala Pro Thr Pro Ala Gly Ala Thr Gly Gly Ser Ser Ala Trp Leu Asp 
    530                 535                 540                 


Ser Ser Ser Glu Asn Arg Gly Leu Gly Ser Glu Leu Ser Lys Pro Gly 
545                 550                 555                 560 


Val Leu Ala Ser Gln Val Asp Ser Pro Phe Ser Gly Cys Phe Glu Asp 
                565                 570                 575     


Leu Ala Ile Ser Ala Ser Thr Ser Leu Gly Met Gly Pro Cys His Gly 
            580                 585                 590         


Pro Glu Glu Asn Glu Tyr Lys Ser Glu Gly Thr Phe Gly Ile His Val 
        595                 600                 605             


Ala Glu Asn Pro Ser Ile Gln Leu Leu Glu Gly Asn Pro Gly Pro Pro 
    610                 615                 620                 


Ala Asp Pro Asp Gly Gly Pro Arg Pro Gln Ala Asp Arg Lys Phe Gln 
625                 630                 635                 640 


Glu Arg Glu Val Pro Cys His Arg Pro Ser Pro 
                645                 650     


<210>  7
<211>  2109
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  7
atggatctgg atctcgaaag aggacctcct ggacctagac ggcctcctag aggaccacct       60

ctgagcagct ctattggact ggccctgctg ctgcttctgc tggctctgct gttctggctg      120

tacatcatca tgagcaactg gaccggcgga gcactgctgg tgctgtatgc ctttgctctg      180

atgctggtca tcatcatcct gatcatcttc atcttccggc gggacctgct gtgtcctctg      240

ggagcacttt gtctgttgct gctgatgatc accctcctgc tgatcgccct gtggaacctg      300

catggacagg ccctgtatct gggcatcgtg ctgttcatct tcggctgcct gctggttctc      360

ggcctgtgga tctacctgct ggaaatcctt tggagactgg gcgccaccat ctggcagctg      420

ctggcctttt tcctggcctt ctttctggat atcatcctcc tcatcattgc cctgtacctg      480

cagcagaact ggtggaccct gctggtggat ctgctttggc tgctgctctt tctggccatc      540

ctgatttgga tgtactacca cggccagcgg ccttctccaa gacactgccc agtggaaaga      600

gagcagttca agagggacgc ccagcctaga cctggcggag atcctgatgc tccacctgga      660

ccaaatggcg agctgctgca gatcagccct aatgaggccg tgcacatcgg cttcaccggc      720

gagtctaagt acgagaacga ggaacccggc cactgtcctg gcatgggcct ttctacatct      780

gcctctatcg ccctggacga gttctgcggc agctttccat ctgatgtgca gtctgccctc      840

gtgggcccta agtctctgga atctggcctg ggcagaaacg agagcagctc cgatctgtgg      900

gctagctctg gtggaacagc tggcgctcct acaccagccg ctcctaccga agagaataga      960

agcagcggcg acacccctgt gacaagcgcc tctgtgaaaa ccctggtcat gagcacccca     1020

gtgaagtccc cagtgatggg cgccagaacc tccaacattc ccctgaagtc tcccgctcct     1080

aacacactgg ccaactctcc agtggctggc cctcctaagt ctagcacccc tctgaaaagc     1140

cccgtgacct ctgtgtctgc ccctaacgct cctgtgaaac tggccgtgac caacgtgccc     1200

atgctgacca cacctgtgaa atccccactg agcaatgccc ctgccgaggc cggaagctct     1260

tgtatcattc ccgaggctca ggatagcgag gctggccaaa aaggcgaagc tgcaggcgct     1320

tctgctctgg gccctagctc tagctctttt agcaccggca ccagcgtggt gtctggcaca     1380

ccaggacctc tgagaagcgc cagacctacc tctagagccc tgcctcagtt tagcgtgtcc     1440

cctagtgtgc ctggcagaag ccctacactg tctagtacag ccggcgctac acacaccagc     1500

ggactggaaa cagaccaaga acagcatggc agcagcaccc tgccttctct ggctgccctt     1560

gattctagca gcgaactgcc aggcggcgac cccaatagac ctatcgctag acctagcctg     1620

acacagctgg cccaagagag caatgagggc ccttctgagc ctgctcagac cgaacaggtg     1680

ccaatgcctt acagccccga gaaagagcgg tgcagcaact accctatcag ccatgccgct     1740

gctcccacac ctcctggtcc aagagaagct cctctgagcc ctcctgagct gcccgatcct     1800

ccaagagata gcaccagacc tcagtactcc cagtacgtgt ccgccgtgga agatgccctg     1860

gatgtgctgg aatgtggcag actggccgcc atcttctacg aagtgtgggg ccctagaagg     1920

cagctgacca actttctgca ctggctgacc gacagaaacg gcagcctgac atgtaccgcc     1980

agactgagag atcaggaccg ggccacactg tgccctctgt atcctctgat cgaggtggtg     2040

gacgtgaact gcttcaacag cttcaaccgg tgcatctaca agtacaccaa ggacgaggct     2100

ttccctatg                                                             2109


<210>  8
<211>  703
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Fusion of LMP1 of Epstein Barr virus and IPS1 of Homo sapiens

<400>  8

Met Asp Leu Asp Leu Glu Arg Gly Pro Pro Gly Pro Arg Arg Pro Pro 
1               5                   10                  15      


Arg Gly Pro Pro Leu Ser Ser Ser Ile Gly Leu Ala Leu Leu Leu Leu 
            20                  25                  30          


Leu Leu Ala Leu Leu Phe Trp Leu Tyr Ile Ile Met Ser Asn Trp Thr 
        35                  40                  45              


Gly Gly Ala Leu Leu Val Leu Tyr Ala Phe Ala Leu Met Leu Val Ile 
    50                  55                  60                  


Ile Ile Leu Ile Ile Phe Ile Phe Arg Arg Asp Leu Leu Cys Pro Leu 
65                  70                  75                  80  


Gly Ala Leu Cys Leu Leu Leu Leu Met Ile Thr Leu Leu Leu Ile Ala 
                85                  90                  95      


Leu Trp Asn Leu His Gly Gln Ala Leu Tyr Leu Gly Ile Val Leu Phe 
            100                 105                 110         


Ile Phe Gly Cys Leu Leu Val Leu Gly Leu Trp Ile Tyr Leu Leu Glu 
        115                 120                 125             


Ile Leu Trp Arg Leu Gly Ala Thr Ile Trp Gln Leu Leu Ala Phe Phe 
    130                 135                 140                 


Leu Ala Phe Phe Leu Asp Ile Ile Leu Leu Ile Ile Ala Leu Tyr Leu 
145                 150                 155                 160 


Gln Gln Asn Trp Trp Thr Leu Leu Val Asp Leu Leu Trp Leu Leu Leu 
                165                 170                 175     


Phe Leu Ala Ile Leu Ile Trp Met Tyr Tyr His Gly Gln Arg Pro Ser 
            180                 185                 190         


Pro Arg His Cys Pro Val Glu Arg Glu Gln Phe Lys Arg Asp Ala Gln 
        195                 200                 205             


Pro Arg Pro Gly Gly Asp Pro Asp Ala Pro Pro Gly Pro Asn Gly Glu 
    210                 215                 220                 


Leu Leu Gln Ile Ser Pro Asn Glu Ala Val His Ile Gly Phe Thr Gly 
225                 230                 235                 240 


Glu Ser Lys Tyr Glu Asn Glu Glu Pro Gly His Cys Pro Gly Met Gly 
                245                 250                 255     


Leu Ser Thr Ser Ala Ser Ile Ala Leu Asp Glu Phe Cys Gly Ser Phe 
            260                 265                 270         


Pro Ser Asp Val Gln Ser Ala Leu Val Gly Pro Lys Ser Leu Glu Ser 
        275                 280                 285             


Gly Leu Gly Arg Asn Glu Ser Ser Ser Asp Leu Trp Ala Ser Ser Gly 
    290                 295                 300                 


Gly Thr Ala Gly Ala Pro Thr Pro Ala Ala Pro Thr Glu Glu Asn Arg 
305                 310                 315                 320 


Ser Ser Gly Asp Thr Pro Val Thr Ser Ala Ser Val Lys Thr Leu Val 
                325                 330                 335     


Met Ser Thr Pro Val Lys Ser Pro Val Met Gly Ala Arg Thr Ser Asn 
            340                 345                 350         


Ile Pro Leu Lys Ser Pro Ala Pro Asn Thr Leu Ala Asn Ser Pro Val 
        355                 360                 365             


Ala Gly Pro Pro Lys Ser Ser Thr Pro Leu Lys Ser Pro Val Thr Ser 
    370                 375                 380                 


Val Ser Ala Pro Asn Ala Pro Val Lys Leu Ala Val Thr Asn Val Pro 
385                 390                 395                 400 


Met Leu Thr Thr Pro Val Lys Ser Pro Leu Ser Asn Ala Pro Ala Glu 
                405                 410                 415     


Ala Gly Ser Ser Cys Ile Ile Pro Glu Ala Gln Asp Ser Glu Ala Gly 
            420                 425                 430         


Gln Lys Gly Glu Ala Ala Gly Ala Ser Ala Leu Gly Pro Ser Ser Ser 
        435                 440                 445             


Ser Phe Ser Thr Gly Thr Ser Val Val Ser Gly Thr Pro Gly Pro Leu 
    450                 455                 460                 


Arg Ser Ala Arg Pro Thr Ser Arg Ala Leu Pro Gln Phe Ser Val Ser 
465                 470                 475                 480 


Pro Ser Val Pro Gly Arg Ser Pro Thr Leu Ser Ser Thr Ala Gly Ala 
                485                 490                 495     


Thr His Thr Ser Gly Leu Glu Thr Asp Gln Glu Gln His Gly Ser Ser 
            500                 505                 510         


Thr Leu Pro Ser Leu Ala Ala Leu Asp Ser Ser Ser Glu Leu Pro Gly 
        515                 520                 525             


Gly Asp Pro Asn Arg Pro Ile Ala Arg Pro Ser Leu Thr Gln Leu Ala 
    530                 535                 540                 


Gln Glu Ser Asn Glu Gly Pro Ser Glu Pro Ala Gln Thr Glu Gln Val 
545                 550                 555                 560 


Pro Met Pro Tyr Ser Pro Glu Lys Glu Arg Cys Ser Asn Tyr Pro Ile 
                565                 570                 575     


Ser His Ala Ala Ala Pro Thr Pro Pro Gly Pro Arg Glu Ala Pro Leu 
            580                 585                 590         


Ser Pro Pro Glu Leu Pro Asp Pro Pro Arg Asp Ser Thr Arg Pro Gln 
        595                 600                 605             


Tyr Ser Gln Tyr Val Ser Ala Val Glu Asp Ala Leu Asp Val Leu Glu 
    610                 615                 620                 


Cys Gly Arg Leu Ala Ala Ile Phe Tyr Glu Val Trp Gly Pro Arg Arg 
625                 630                 635                 640 


Gln Leu Thr Asn Phe Leu His Trp Leu Thr Asp Arg Asn Gly Ser Leu 
                645                 650                 655     


Thr Cys Thr Ala Arg Leu Arg Asp Gln Asp Arg Ala Thr Leu Cys Pro 
            660                 665                 670         


Leu Tyr Pro Leu Ile Glu Val Val Asp Val Asn Cys Phe Asn Ser Phe 
        675                 680                 685             


Asn Arg Cys Ile Tyr Lys Tyr Thr Lys Asp Glu Ala Phe Pro Met 
    690                 695                 700             


