                         SEQUENCE LISTING

<110>  Inserm
 
<120>  METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF 
       RETINAL DEGENERATIVE DISEASES

<130>  BIO16459 LEVEILLARD / MC

<160>  3     

<170>  PatentIn version 3.3

<210>  1
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Gly Ala Ser Ser Ser Glu Gln Asn Asn Asn Ser Tyr Glu Thr 
1               5                   10                  15      


Lys Thr Pro Asn Leu Arg Met Ser Glu Lys Lys Cys Ser Trp Ala Ser 
            20                  25                  30          


Tyr Met Thr Asn Ser Pro Thr Leu Ile Val Met Ile Gly Leu Pro Ala 
        35                  40                  45              


Arg Gly Lys Thr Tyr Val Ser Lys Lys Leu Thr Arg Tyr Leu Asn Trp 
    50                  55                  60                  


Ile Gly Val Pro Thr Lys Val Phe Asn Leu Gly Val Tyr Arg Arg Glu 
65                  70                  75                  80  


Ala Val Lys Ser Tyr Lys Ser Tyr Asp Phe Phe Arg His Asp Asn Glu 
                85                  90                  95      


Glu Ala Met Lys Ile Arg Lys Gln Cys Ala Leu Val Ala Leu Glu Asp 
            100                 105                 110         


Val Lys Ala Tyr Leu Thr Glu Glu Asn Gly Gln Ile Ala Val Phe Asp 
        115                 120                 125             


Ala Thr Asn Thr Thr Arg Glu Arg Arg Asp Met Ile Leu Asn Phe Ala 
    130                 135                 140                 


Glu Gln Asn Ser Phe Lys Val Phe Phe Val Glu Ser Val Cys Asp Asp 
145                 150                 155                 160 


Pro Asp Val Ile Ala Ala Asn Ile Leu Glu Val Lys Val Ser Ser Pro 
                165                 170                 175     


Asp Tyr Pro Glu Arg Asn Arg Glu Asn Val Met Glu Asp Phe Leu Lys 
            180                 185                 190         


Arg Ile Glu Cys Tyr Lys Val Thr Tyr Arg Pro Leu Asp Pro Asp Asn 
        195                 200                 205             


Tyr Asp Lys Asp Leu Ser Phe Ile Lys Val Ile Asn Val Gly Gln Arg 
    210                 215                 220                 


Phe Leu Val Asn Arg Val Gln Asp Tyr Ile Gln Ser Lys Ile Val Tyr 
225                 230                 235                 240 


Tyr Leu Met Asn Ile His Val Gln Pro Arg Thr Ile Tyr Leu Cys Arg 
                245                 250                 255     


His Gly Glu Ser Glu Phe Asn Leu Leu Gly Lys Ile Gly Gly Asp Ser 
            260                 265                 270         


Gly Leu Ser Val Arg Gly Lys Gln Phe Ala Gln Ala Leu Arg Lys Phe 
        275                 280                 285             


Leu Glu Glu Gln Glu Ile Thr Asp Leu Lys Val Trp Thr Ser Gln Leu 
    290                 295                 300                 


Lys Arg Thr Ile Gln Thr Ala Glu Ser Leu Gly Val Pro Tyr Glu Gln 
305                 310                 315                 320 


Trp Lys Ile Leu Asn Glu Ile Asp Ala Gly Val Cys Glu Glu Met Thr 
                325                 330                 335     


Tyr Ala Glu Ile Glu Lys Arg Tyr Pro Glu Glu Phe Ala Leu Arg Asp 
            340                 345                 350         


Gln Glu Lys Tyr Leu Tyr Arg Tyr Pro Gly Gly Glu Ser Tyr Gln Asp 
        355                 360                 365             


Leu Val Gln Arg Leu Glu Pro Val Ile Met Glu Leu Glu Arg Gln Gly 
    370                 375                 380                 


Asn Val Leu Val Ile Ser His Gln Ala Val Met Arg Cys Leu Leu Ala 
385                 390                 395                 400 


Tyr Phe Leu Asp Lys Gly Ala Asp Glu Leu Pro Tyr Leu Arg Cys Pro 
                405                 410                 415     


Leu His Thr Ile Phe Lys Leu Thr Pro Val Ala Tyr Gly Cys Lys Val 
            420                 425                 430         


Glu Thr Ile Lys Leu Asn Val Glu Ala Val Asn Thr His Arg Asp Lys 
        435                 440                 445             


Pro Thr Asn Asn Phe Pro Lys Asn Gln Thr Pro Val Arg Met Arg Arg 
    450                 455                 460                 


Asn Ser Phe Thr Pro Leu Ser Ser Ser Asn Thr Ile Arg Arg Pro Arg 
465                 470                 475                 480 


Asn Tyr Ser Val Gly Ser Arg Pro Leu Lys Pro Leu Ser Pro Leu Arg 
                485                 490                 495     


Ala Gln Asp Met Gln Glu Gly Ala Asp 
            500                 505 


<210>  2
<211>  248
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Gly Ala Ser Ser Ser Glu Gln Asn Asn Asn Ser Tyr Glu Thr 
1               5                   10                  15      


Lys Thr Pro Asn Leu Arg Met Ser Glu Lys Lys Cys Ser Trp Ala Ser 
            20                  25                  30          


Tyr Met Thr Asn Ser Pro Thr Leu Ile Val Met Ile Gly Leu Pro Ala 
        35                  40                  45              


Arg Gly Lys Thr Tyr Val Ser Lys Lys Leu Thr Arg Tyr Leu Asn Trp 
    50                  55                  60                  


Ile Gly Val Pro Thr Lys Val Phe Asn Leu Gly Val Tyr Arg Arg Glu 
65                  70                  75                  80  


Ala Val Lys Ser Tyr Lys Ser Tyr Asp Phe Phe Arg His Asp Asn Glu 
                85                  90                  95      


Glu Ala Met Lys Ile Arg Lys Gln Cys Ala Leu Val Ala Leu Glu Asp 
            100                 105                 110         


Val Lys Ala Tyr Leu Thr Glu Glu Asn Gly Gln Ile Ala Val Phe Asp 
        115                 120                 125             


Ala Thr Asn Thr Thr Arg Glu Arg Arg Asp Met Ile Leu Asn Phe Ala 
    130                 135                 140                 


Glu Gln Asn Ser Phe Lys Val Phe Phe Val Glu Ser Val Cys Asp Asp 
145                 150                 155                 160 


Pro Asp Val Ile Ala Ala Asn Ile Leu Glu Val Lys Val Ser Ser Pro 
                165                 170                 175     


Asp Tyr Pro Glu Arg Asn Arg Glu Asn Val Met Glu Asp Phe Leu Lys 
            180                 185                 190         


Arg Ile Glu Cys Tyr Lys Val Thr Tyr Arg Pro Leu Asp Pro Asp Asn 
        195                 200                 205             


Tyr Asp Lys Asp Leu Ser Phe Ile Lys Val Ile Asn Val Gly Gln Arg 
    210                 215                 220                 


Phe Leu Val Asn Arg Val Gln Asp Tyr Ile Gln Ser Lys Ile Val Tyr 
225                 230                 235                 240 


Tyr Leu Met Asn Ile His Val Gln 
                245             


<210>  3
<211>  747
<212>  DNA
<213>  Homo sapiens

<400>  3
atgtctgggg catcttcctc agaacagaac aacaacagct atgaaaccaa aaccccaaat     60

cttcgaatgt cagagaagaa atgttcatgg gccgcctaca tgaccaactc cccgactctg    120

atcgttatga ttggtttgcc agcccggggt aaaacctacg tgtccaagaa actaacacgc    180

tacctcaact ggattggagt ccccaccaaa gtgtttaatc ttggggtgta tcggcgtgaa    240

gcagtcaagt cctataagtc ctacgacttc tttcggcatg acaatgagga ggccatgaag    300

atccgcaaac agtgtgctct ggtggcgctg gaagatgtta aggcgtatct cactgaggag    360

aatggtcaga ttgcggtgtt tgatgccacc aatacaaccc gggagaggag ggacatgatt    420

ttgaactttg ctgaacagaa ttccttcaag gtattctttg tggaatccgt ctgtgatgat    480

cctgatgtca ttgctgccaa tattctggag gttaaggtat caagccctga ctatcctgaa    540

aggaacagag agaacgtgat ggaggacttc ctgaagagaa ttgaatgcta caaagttacc    600

taccgacctc ttgacccaga caactatgac aaggatcttt ctttcatcaa ggtgataaac    660

gtgggccagc gatttttagt caacagagtc caggactaca tccagagcaa gatagtctac    720

tacctcatga atatccacgt ccagtaa                                        747


