                         SEQUENCE LISTING

<110>  University of Southampton
 
<120>  Therapeutic Agent Screen

<130>  JA86852P.WOP

<150>  GB1621024.7
<151>  2016-12-11

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Glu Ala Ile Ile Leu Leu Ala Leu Leu Gly Ala Met Ser Gly 
1               5                   10                  15      


Gly Glu Ala Leu His Leu Ile Leu Leu Pro Ala Thr Gly Asn Val Ala 
            20                  25                  30          


Glu Asn Ser Pro Pro Gly Thr Ser Val His Lys Phe Ser Val Lys Leu 
        35                  40                  45              


Ser Ala Ser Leu Ser Pro Val Ile Pro Gly Phe Pro Gln Ile Val Asn 
    50                  55                  60                  


Ser Asn Pro Leu Thr Glu Ala Phe Arg Val Asn Trp Leu Ser Gly Thr 
65                  70                  75                  80  


Tyr Phe Glu Val Val Thr Thr Gly Met Glu Gln Leu Asp Phe Glu Thr 
                85                  90                  95      


Gly Pro Asn Ile Phe Asp Leu Gln Ile Tyr Val Lys Asp Glu Val Gly 
            100                 105                 110         


Val Thr Asp Leu Gln Val Leu Thr Val Gln Val Thr Asp Val Asn Glu 
        115                 120                 125             


Pro Pro Gln Phe Gln Gly Asn Leu Ala Glu Gly Leu His Leu Tyr Ile 
    130                 135                 140                 


Val Glu Arg Ala Asn Pro Gly Phe Ile Tyr Gln Val Glu Ala Phe Asp 
145                 150                 155                 160 


Pro Glu Asp Thr Ser Arg Asn Ile Pro Leu Ser Tyr Phe Leu Ile Ser 
                165                 170                 175     


Pro Pro Lys Ser Phe Arg Met Ser Ala Asn Gly Thr Leu Phe Ser Thr 
            180                 185                 190         


Thr Glu Leu Asp Phe Glu Ala Gly His Arg Ser Phe His Leu Ile Val 
        195                 200                 205             


Glu Val Arg Asp Ser Gly Gly Leu Lys Ala Ser Thr Glu Leu Gln Val 
    210                 215                 220                 


Asn Ile Val Asn Leu Asn Asp Glu Val Pro Arg Phe Thr Ser Pro Thr 
225                 230                 235                 240 


Arg Val Tyr Thr Val Leu Glu Glu Leu Ser Pro Gly Thr Ile Val Ala 
                245                 250                 255     


Asn Ile Thr Ala Glu Asp Pro Asp Asp Glu Gly Phe Pro Ser His Leu 
            260                 265                 270         


Leu Tyr Ser Ile Thr Thr Val Ser Lys Tyr Phe Met Ile Asn Gln Leu 
        275                 280                 285             


Thr Gly Thr Ile Gln Val Ala Gln Arg Ile Asp Arg Asp Ala Gly Glu 
    290                 295                 300                 


Leu Arg Gln Asn Pro Thr Ile Ser Leu Glu Val Leu Val Lys Asp Arg 
305                 310                 315                 320 


Pro Tyr Gly Gly Gln Glu Asn Arg Ile Gln Ile Thr Phe Ile Val Glu 
                325                 330                 335     


Asp Val Asn Asp Asn Pro Ala Thr Cys Gln Lys Phe Thr Phe Ser Ile 
            340                 345                 350         


Met Val Pro Glu Arg Thr Ala Lys Gly Thr Leu Leu Leu Asp Leu Asn 
        355                 360                 365             


Lys Phe Cys Phe Asp Asp Asp Ser Glu Ala Pro Asn Asn Arg Phe Asn 
    370                 375                 380                 


Phe Thr Met Pro Ser Gly Val Gly Ser Gly Ser Arg Phe Leu Gln Asp 
385                 390                 395                 400 


Pro Ala Gly Ser Gly Lys Ile Val Leu Ile Gly Asp Leu Asp Tyr Glu 
                405                 410                 415     


Asn Pro Ser Asn Leu Ala Ala Gly Asn Lys Tyr Thr Val Ile Ile Gln 
            420                 425                 430         


Val Gln Asp Val Ala Pro Pro Tyr Tyr Lys Asn Asn Val Tyr Val Tyr 
        435                 440                 445             


Ile Leu Thr Ser Pro Glu Asn Glu Phe Pro Leu Ile Phe Asp Arg Pro 
    450                 455                 460                 


Ser Tyr Val Phe Asp Val Ser Glu Arg Arg Pro Ala Arg Thr Arg Val 
465                 470                 475                 480 


Gly Gln Val Arg Ala Thr Asp Lys Asp Leu Pro Gln Ser Ser Leu Leu 
                485                 490                 495     


Tyr Ser Ile Ser Thr Gly Gly Ala Ser Leu Gln Tyr Pro Asn Val Phe 
            500                 505                 510         


Trp Ile Asn Pro Lys Thr Gly Glu Leu Gln Leu Val Thr Lys Val Asp 
        515                 520                 525             


Cys Glu Thr Thr Pro Ile Tyr Ile Leu Arg Ile Gln Ala Thr Asn Asn 
    530                 535                 540                 


Glu Asp Thr Ser Ser Val Thr Val Thr Val Asn Ile Leu Glu Glu Asn 
545                 550                 555                 560 


Asp Glu Lys Pro Ile Cys Thr Pro Asn Ser Tyr Phe Leu Ala Leu Pro 
                565                 570                 575     


Val Asp Leu Lys Val Gly Thr Asn Ile Gln Asn Phe Lys Leu Thr Cys 
            580                 585                 590         


Thr Asp Leu Asp Ser Ser Pro Arg Ser Phe Arg Tyr Ser Ile Gly Pro 
        595                 600                 605             


Gly Asn Val Asn Asn His Phe Thr Phe Ser Pro Asn Ala Gly Ser Asn 
    610                 615                 620                 


Val Thr Arg Leu Leu Leu Thr Ser Arg Phe Asp Tyr Ala Gly Gly Phe 
625                 630                 635                 640 


Asp Lys Ile Trp Asp Tyr Lys Leu Leu Val Tyr Val Thr Asp Asp Asn 
                645                 650                 655     


Leu Met Ser Asp Arg Lys Lys Ala Glu Ala Leu Val Glu Thr Gly Thr 
            660                 665                 670         


Val Thr Leu Ser Ile Lys Val Ile Pro His Pro Thr Thr Ile Ile Thr 
        675                 680                 685             


Thr Thr Pro Arg Pro Arg Val Thr Tyr Gln Val Leu Arg Lys Asn Val 
    690                 695                 700                 


Tyr Ser Pro Ser Ala Trp Tyr Val Pro Phe Val Ile Thr Leu Gly Ser 
705                 710                 715                 720 


Ile Leu Leu Leu Gly Leu Leu Val Tyr Leu Val Val Leu Leu Ala Lys 
                725                 730                 735     


Ala Ile His Arg His Cys Pro Cys Lys Thr Gly Lys Asn Lys Glu Pro 
            740                 745                 750         


Leu Thr Lys Lys Gly Glu Thr Lys Thr Ala Glu Arg Asp Val Val Val 
        755                 760                 765             


Glu Thr Ile Gln Met Asn Thr Ile Phe Asp Gly Glu Ala Ile Asp Pro 
    770                 775                 780                 


Val Thr Gly Glu Thr Tyr Glu Phe Asn Ser Lys Thr Gly Ala Arg Lys 
785                 790                 795                 800 


Trp Lys Asp Pro Leu Thr Gln Met Pro Lys Trp Lys Glu Ser Ser His 
                805                 810                 815     


Gln Gly Ala Ala Pro Arg Arg Val Thr Ala Gly Glu Gly Met Gly Ser 
            820                 825                 830         


Leu Arg Ser Ala Asn Trp Glu Glu Asp Glu Leu Ser Gly Lys Ala Trp 
        835                 840                 845             


Ala Glu Asp Ala Gly Leu Gly Ser Arg Asn Glu Gly Gly Lys Leu Gly 
    850                 855                 860                 


Asn Pro Lys Asn Arg Asn Pro Ala Phe Met Asn Arg Ala Tyr Pro Lys 
865                 870                 875                 880 


Pro His Pro Gly Lys 
                885 


<210>  2
<211>  885
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Glu Ala Ile Ile Leu Leu Ala Leu Leu Gly Ala Met Ser Gly 
1               5                   10                  15      


Gly Glu Ala Leu His Leu Ile Leu Leu Pro Ala Thr Gly Asn Val Ala 
            20                  25                  30          


Glu Asn Ser Pro Pro Gly Thr Ser Val His Lys Phe Ser Val Lys Leu 
        35                  40                  45              


Ser Ala Ser Leu Ser Pro Val Ile Pro Gly Phe Pro Gln Ile Val Asn 
    50                  55                  60                  


Ser Asn Pro Leu Thr Glu Ala Phe Arg Val Asn Trp Leu Ser Gly Thr 
65                  70                  75                  80  


Tyr Phe Glu Val Val Thr Thr Gly Met Glu Gln Leu Asp Phe Glu Thr 
                85                  90                  95      


Gly Pro Asn Ile Phe Asp Leu Gln Ile Tyr Val Lys Asp Glu Val Gly 
            100                 105                 110         


Val Thr Asp Leu Gln Val Leu Thr Val Gln Val Thr Asp Val Asn Glu 
        115                 120                 125             


Pro Pro Gln Phe Gln Gly Asn Leu Ala Glu Gly Leu His Leu Tyr Ile 
    130                 135                 140                 


Val Glu Arg Ala Asn Pro Gly Phe Ile Tyr Gln Val Glu Ala Phe Asp 
145                 150                 155                 160 


Pro Glu Asp Thr Ser Arg Asn Ile Pro Leu Ser Tyr Phe Leu Ile Ser 
                165                 170                 175     


Pro Pro Lys Ser Phe Arg Met Ser Ala Asn Gly Thr Leu Phe Ser Thr 
            180                 185                 190         


Thr Glu Leu Asp Phe Glu Ala Gly His Arg Ser Phe His Leu Ile Val 
        195                 200                 205             


Glu Val Arg Asp Ser Gly Gly Leu Lys Ala Ser Thr Glu Leu Gln Val 
    210                 215                 220                 


Asn Ile Val Asn Leu Asn Asp Glu Val Pro Arg Phe Thr Ser Pro Thr 
225                 230                 235                 240 


Arg Val Tyr Thr Val Leu Glu Glu Leu Ser Pro Gly Thr Ile Val Ala 
                245                 250                 255     


Asn Ile Thr Ala Glu Asp Pro Asp Asp Glu Gly Phe Pro Ser His Leu 
            260                 265                 270         


Leu Tyr Ser Ile Thr Thr Val Ser Lys Tyr Phe Met Ile Asn Gln Leu 
        275                 280                 285             


Thr Gly Thr Ile Gln Val Ala Gln Arg Ile Asp Arg Asp Ala Gly Glu 
    290                 295                 300                 


Leu Arg Gln Asn Pro Thr Ile Ser Leu Glu Val Leu Val Lys Asp Arg 
305                 310                 315                 320 


Pro Tyr Gly Gly Gln Glu Asn Arg Ile Gln Ile Thr Phe Ile Val Glu 
                325                 330                 335     


Asp Val Asn Asp Asn Pro Ala Thr Cys Gln Lys Phe Thr Phe Ser Ile 
            340                 345                 350         


Met Val Pro Glu Arg Thr Ala Lys Gly Thr Leu Leu Leu Asp Leu Asn 
        355                 360                 365             


Lys Phe Cys Phe Asp Asp Asp Ser Glu Ala Pro Asn Asn Arg Phe Asn 
    370                 375                 380                 


Phe Thr Met Pro Ser Gly Val Gly Ser Gly Ser Arg Phe Leu Gln Asp 
385                 390                 395                 400 


Pro Ala Gly Ser Gly Lys Ile Val Leu Ile Gly Asp Leu Asp Tyr Glu 
                405                 410                 415     


Asn Pro Ser Asn Leu Ala Ala Gly Asn Lys Tyr Thr Val Ile Ile Gln 
            420                 425                 430         


Val Gln Asp Val Ala Pro Pro Tyr Tyr Lys Asn Asn Val Tyr Val Tyr 
        435                 440                 445             


Ile Leu Thr Ser Pro Glu Asn Glu Phe Pro Leu Ile Phe Asp Arg Pro 
    450                 455                 460                 


Ser Tyr Val Phe Asp Val Ser Glu Arg Arg Pro Ala Arg Thr Arg Val 
465                 470                 475                 480 


Gly Gln Val Arg Ala Thr Asp Lys Asp Leu Pro Gln Ser Ser Leu Leu 
                485                 490                 495     


Tyr Ser Ile Ser Thr Gly Gly Ala Ser Leu Gln Tyr Pro Asn Val Phe 
            500                 505                 510         


Trp Ile Asn Pro Lys Thr Gly Glu Leu Gln Leu Val Thr Lys Val Asp 
        515                 520                 525             


Tyr Glu Thr Thr Pro Ile Tyr Ile Leu Arg Ile Gln Ala Thr Asn Asn 
    530                 535                 540                 


Glu Asp Thr Ser Ser Val Thr Val Thr Val Asn Ile Leu Glu Glu Asn 
545                 550                 555                 560 


Asp Glu Lys Pro Ile Cys Thr Pro Asn Ser Tyr Phe Leu Ala Leu Pro 
                565                 570                 575     


Val Asp Leu Lys Val Gly Thr Asn Ile Gln Asn Phe Lys Leu Thr Cys 
            580                 585                 590         


Thr Asp Leu Asp Ser Ser Pro Arg Ser Phe Arg Tyr Ser Ile Gly Pro 
        595                 600                 605             


Gly Asn Val Asn Asn His Phe Thr Phe Ser Pro Asn Ala Gly Ser Asn 
    610                 615                 620                 


Val Thr Arg Leu Leu Leu Thr Ser Arg Phe Asp Tyr Ala Gly Gly Phe 
625                 630                 635                 640 


Asp Lys Ile Trp Asp Tyr Lys Leu Leu Val Tyr Val Thr Asp Asp Asn 
                645                 650                 655     


Leu Met Ser Asp Arg Lys Lys Ala Glu Ala Leu Val Glu Thr Gly Thr 
            660                 665                 670         


Val Thr Leu Ser Ile Lys Val Ile Pro His Pro Thr Thr Ile Ile Thr 
        675                 680                 685             


Thr Thr Pro Arg Pro Arg Val Thr Tyr Gln Val Leu Arg Lys Asn Val 
    690                 695                 700                 


Tyr Ser Pro Ser Ala Trp Tyr Val Pro Phe Val Ile Thr Leu Gly Ser 
705                 710                 715                 720 


Ile Leu Leu Leu Gly Leu Leu Val Tyr Leu Val Val Leu Leu Ala Lys 
                725                 730                 735     


Ala Ile His Arg His Cys Pro Cys Lys Thr Gly Lys Asn Lys Glu Pro 
            740                 745                 750         


Leu Thr Lys Lys Gly Glu Thr Lys Thr Ala Glu Arg Asp Val Val Val 
        755                 760                 765             


Glu Thr Ile Gln Met Asn Thr Ile Phe Asp Gly Glu Ala Ile Asp Pro 
    770                 775                 780                 


Val Thr Gly Glu Thr Tyr Glu Phe Asn Ser Lys Thr Gly Ala Arg Lys 
785                 790                 795                 800 


Trp Lys Asp Pro Leu Thr Gln Met Pro Lys Trp Lys Glu Ser Ser His 
                805                 810                 815     


Gln Gly Ala Ala Pro Arg Arg Val Thr Ala Gly Glu Gly Met Gly Ser 
            820                 825                 830         


Leu Arg Ser Ala Asn Trp Glu Glu Asp Glu Leu Ser Gly Lys Ala Trp 
        835                 840                 845             


Ala Glu Asp Ala Gly Leu Gly Ser Arg Asn Glu Gly Gly Lys Leu Gly 
    850                 855                 860                 


Asn Pro Lys Asn Arg Asn Pro Ala Phe Met Asn Arg Ala Tyr Pro Lys 
865                 870                 875                 880 


Pro His Pro Gly Lys 
                885 


<210>  3
<211>  813
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln 
            20                  25                  30          


Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly 
        35                  40                  45              


Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp 
    50                  55                  60                  


Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His 
                85                  90                  95      


Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Asp 
            100                 105                 110         


His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp Val 
        115                 120                 125             


Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser Arg 
    130                 135                 140                 


Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys Asp 
145                 150                 155                 160 


Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp Lys 
                165                 170                 175     


Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr Ser 
            180                 185                 190         


Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg Thr 
        195                 200                 205             


Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe Leu 
    210                 215                 220                 


Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val Ala 
                245                 250                 255     


Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val Thr 
            260                 265                 270         


Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg Gly 
        275                 280                 285             


Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly Arg 
    290                 295                 300                 


Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met Cys 
305                 310                 315                 320 


Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu Pro 
                325                 330                 335     


Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His Ser Leu Gly 
            340                 345                 350         


Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu Ser 
        355                 360                 365             


Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg Val 
    370                 375                 380                 


Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys Gly 
385                 390                 395                 400 


Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val Pro 
                405                 410                 415     


Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp 
            420                 425                 430         


Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His Asn 
        435                 440                 445             


Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys Val 
    450                 455                 460                 


Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met Gly 
465                 470                 475                 480 


Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys Pro 
                485                 490                 495     


Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly 
            500                 505                 510         


Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln 
        515                 520                 525             


Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln Val 
    530                 535                 540                 


Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser Glu 
545                 550                 555                 560 


Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu 
                565                 570                 575     


Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val Pro 
            580                 585                 590         


Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg Gly 
        595                 600                 605             


Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu 
    610                 615                 620                 


Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Gln Ser Arg 
625                 630                 635                 640 


Arg Cys Arg Lys Asn Ala Phe Gln Glu Leu Gln Arg Cys Leu Thr Ala 
                645                 650                 655     


Cys His Ser His Gly Val Cys Asn Ser Asn His Asn Cys His Cys Ala 
            660                 665                 670         


Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys Pro Gly Phe Gly Gly Ser 
        675                 680                 685             


Met Asp Ser Gly Pro Val Gln Ala Glu Asn His Asp Thr Phe Leu Leu 
    690                 695                 700                 


Ala Met Leu Leu Ser Val Leu Leu Pro Leu Leu Pro Gly Ala Gly Leu 
705                 710                 715                 720 


Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala His Leu Gln Arg Cys Ser 
                725                 730                 735     


Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser Gly Pro Lys Asp Gly Pro 
            740                 745                 750         


His Arg Asp His Pro Leu Gly Gly Val His Pro Met Glu Leu Gly Pro 
        755                 760                 765             


Thr Ala Thr Gly Gln Pro Trp Pro Leu Asp Pro Glu Asn Ser His Glu 
    770                 775                 780                 


Pro Ser Ser His Pro Glu Lys Pro Leu Pro Ala Val Ser Pro Asp Pro 
785                 790                 795                 800 


Gln Ala Asp Gln Val Gln Met Pro Arg Ser Cys Leu Trp 
                805                 810             


<210>  4
<211>  813
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Trp Arg Pro Arg Arg Ala Arg Gly Thr Pro Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Trp Pro Val Pro Gly Ala Gly Val Leu Gln 
            20                  25                  30          


Gly His Ile Pro Gly Gln Pro Val Thr Pro His Trp Val Leu Asp Gly 
        35                  40                  45              


Gln Pro Trp Arg Thr Val Ser Leu Glu Glu Pro Val Ser Lys Pro Asp 
    50                  55                  60                  


Met Gly Leu Val Ala Leu Glu Ala Glu Gly Gln Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Leu Glu Lys Asn His Arg Leu Leu Ala Pro Gly Tyr Ile Glu Thr His 
                85                  90                  95      


Tyr Gly Pro Asp Gly Gln Pro Val Val Leu Ala Pro Asn His Thr Asp 
            100                 105                 110         


His Cys His Tyr Gln Gly Arg Val Arg Gly Phe Pro Asp Ser Trp Val 
        115                 120                 125             


Val Leu Cys Thr Cys Ser Gly Met Ser Gly Leu Ile Thr Leu Ser Arg 
    130                 135                 140                 


Asn Ala Ser Tyr Tyr Leu Arg Pro Trp Pro Pro Arg Gly Ser Lys Asp 
145                 150                 155                 160 


Phe Ser Thr His Glu Ile Phe Arg Met Glu Gln Leu Leu Thr Trp Lys 
                165                 170                 175     


Gly Thr Cys Gly His Arg Asp Pro Gly Asn Lys Ala Gly Met Thr Ser 
            180                 185                 190         


Leu Pro Gly Gly Pro Gln Ser Arg Gly Arg Arg Glu Ala Arg Arg Thr 
        195                 200                 205             


Arg Lys Tyr Leu Glu Leu Tyr Ile Val Ala Asp His Thr Leu Phe Leu 
    210                 215                 220                 


Thr Arg His Arg Asn Leu Asn His Thr Lys Gln Arg Leu Leu Glu Val 
225                 230                 235                 240 


Ala Asn Tyr Val Asp Gln Leu Leu Arg Thr Leu Asp Ile Gln Val Ala 
                245                 250                 255     


Leu Thr Gly Leu Glu Val Trp Thr Glu Arg Asp Arg Ser Arg Val Thr 
            260                 265                 270         


Gln Asp Ala Asn Ala Thr Leu Trp Ala Phe Leu Gln Trp Arg Arg Gly 
        275                 280                 285             


Leu Trp Ala Gln Arg Pro His Asp Ser Ala Gln Leu Leu Thr Gly Arg 
    290                 295                 300                 


Ala Phe Gln Gly Ala Thr Val Gly Leu Ala Pro Val Glu Gly Met Cys 
305                 310                 315                 320 


Arg Ala Glu Ser Ser Gly Gly Val Ser Thr Asp His Ser Glu Leu Pro 
                325                 330                 335     


Ile Gly Ala Ala Ala Thr Met Ala His Ala Ile Gly His Ser Leu Gly 
            340                 345                 350         


Leu Ser His Asp Pro Asp Gly Cys Cys Val Glu Ala Ala Ala Glu Ser 
        355                 360                 365             


Gly Gly Cys Val Met Ala Ala Ala Thr Gly His Pro Phe Pro Arg Val 
    370                 375                 380                 


Phe Ser Ala Cys Ser Arg Arg Gln Leu Arg Ala Phe Phe Arg Lys Gly 
385                 390                 395                 400 


Gly Gly Ala Cys Leu Ser Asn Ala Pro Asp Pro Gly Leu Pro Val Pro 
                405                 410                 415     


Pro Ala Leu Cys Gly Asn Gly Phe Val Glu Ala Gly Glu Glu Cys Asp 
            420                 425                 430         


Cys Gly Pro Gly Gln Glu Cys Arg Asp Leu Cys Cys Phe Ala His Asn 
        435                 440                 445             


Cys Ser Leu Arg Pro Gly Ala Gln Cys Ala His Gly Asp Cys Cys Val 
    450                 455                 460                 


Arg Cys Leu Leu Lys Pro Ala Gly Ala Leu Cys Arg Gln Ala Met Gly 
465                 470                 475                 480 


Asp Cys Asp Leu Pro Glu Phe Cys Thr Gly Thr Ser Ser His Cys Pro 
                485                 490                 495     


Pro Asp Val Tyr Leu Leu Asp Gly Ser Pro Cys Ala Arg Gly Ser Gly 
            500                 505                 510         


Tyr Cys Trp Asp Gly Ala Cys Pro Thr Leu Glu Gln Gln Cys Gln Gln 
        515                 520                 525             


Leu Trp Gly Pro Gly Ser His Pro Ala Pro Glu Ala Cys Phe Gln Val 
    530                 535                 540                 


Val Asn Ser Ala Gly Asp Ala His Gly Asn Cys Gly Gln Asp Ser Glu 
545                 550                 555                 560 


Gly His Phe Leu Pro Cys Ala Gly Arg Asp Ala Leu Cys Gly Lys Leu 
                565                 570                 575     


Gln Cys Gln Gly Gly Lys Pro Ser Leu Leu Ala Pro His Met Val Pro 
            580                 585                 590         


Val Asp Ser Thr Val His Leu Asp Gly Gln Glu Val Thr Cys Arg Gly 
        595                 600                 605             


Ala Leu Ala Leu Pro Ser Ala Gln Leu Asp Leu Leu Gly Leu Gly Leu 
    610                 615                 620                 


Val Glu Pro Gly Thr Gln Cys Gly Pro Arg Met Val Cys Gln Ser Arg 
625                 630                 635                 640 


Arg Cys Arg Lys Asn Ala Phe Gln Glu Leu Gln Arg Cys Leu Thr Ala 
                645                 650                 655     


Cys His Ser His Gly Val Cys Asn Ser Asn His Asn Cys His Cys Ala 
            660                 665                 670         


Pro Gly Trp Ala Pro Pro Phe Cys Asp Lys Pro Gly Phe Gly Gly Ser 
        675                 680                 685             


Met Asp Ser Gly Pro Val Gln Ala Glu Asn His Asp Thr Phe Leu Leu 
    690                 695                 700                 


Ala Met Leu Leu Ser Val Leu Leu Pro Leu Leu Pro Gly Ala Gly Leu 
705                 710                 715                 720 


Ala Trp Cys Cys Tyr Arg Leu Pro Gly Ala His Leu Gln Arg Cys Ser 
                725                 730                 735     


Trp Gly Cys Arg Arg Asp Pro Ala Cys Ser Gly Pro Lys Asp Gly Pro 
            740                 745                 750         


His Arg Asp His Pro Leu Gly Gly Val His Pro Met Glu Leu Gly Pro 
        755                 760                 765             


Thr Ala Thr Gly Gln Pro Trp Pro Leu Asp Pro Glu Asn Ser His Glu 
    770                 775                 780                 


Pro Ser Ser His Pro Glu Lys Pro Leu Pro Ala Val Ser Pro Asp Pro 
785                 790                 795                 800 


Gln Ala Asp Gln Val Gln Met Pro Arg Ser Cys Leu Trp 
                805                 810             


<210>  5
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

His Glu Xaa Gly His Xaa Xaa Gly Xaa Xaa His Asp 
1               5                   10          


<210>  6
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  6

Glu Leu Pro Ile Gly Ala Ala Ala Thr Met Ala His Glu Ile Gly His 
1               5                   10                  15      


Ser Leu Gly Leu Ser His Asp Pro Asp 
            20                  25  


<210>  7
<211>  25
<212>  PRT
<213>  Musca domestica

<400>  7

Glu Leu Pro Ile Gly Thr Ala Ala Thr Met Ala His Glu Ile Gly His 
1               5                   10                  15      


Ser Leu Gly Leu His His Asp Pro Glu 
            20                  25  


<210>  8
<211>  25
<212>  PRT
<213>  Drosophila melanogaster

<400>  8

Val Ile Thr Arg Glu Ala Asp Leu Val Thr Ala His Glu Phe Gly His 
1               5                   10                  15      


Asn Trp Gly Ser Glu His Asp Pro Asp 
            20                  25  


<210>  9
<211>  25
<212>  PRT
<213>  Drosophila melanogaster

<400>  9

Pro Asn Pro Ala Met Val Ala Thr Thr Met Ala His Glu Met Gly His 
1               5                   10                  15      


Asn Phe Gly Met Glu His Asp Thr Ser 
            20                  25  


<210>  10
<211>  25
<212>  PRT
<213>  Drosophila melanogaster

<400>  10

Tyr Glu Pro His Leu Leu Ala Gly Thr Met Ala His Met Ile Gly His 
1               5                   10                  15      


Asn Ile Gly Met Gly His Asp Asp Gly 
            20                  25  


<210>  11
<211>  25
<212>  PRT
<213>  Drosophila melanogaster

<400>  11

Val Pro Pro Lys Val Ser Gln Leu Thr Leu Ala His Glu Ile Gly His 
1               5                   10                  15      


Asn Phe Gly Ser Pro His Asp Tyr Pro 
            20                  25  


