                               SEQUENCE LISTING

<110> THE JOHNS HOPKINS UNIVERSITY
 
<120> ORTHOGONAL TRANSCRIPTIONAL SWITCHES DERIVED FROM TET REPRESSOR 
      HOMOLOGS FOR SACCHAROMYCES CEREVISIAE

<130> 048317-530001WO

<140> PCT/US2017/065067
<141> 2017-12-07

<150> 62/431,170
<151> 2016-12-07

<160> 36    

<170> PatentIn version 3.5

<210> 1
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 1
tccacaatca attgcgagaa gc                                                22


<210> 2
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 2
catttgttgg aggaaagttg tcc                                               23


<210> 3
<211> 40
<212> DNA
<213> Pseudomonas sp.

<400> 3
tatgtatgat acgaaacgta ccgtatcgtt aaggtagcgt                             40


<210> 4
<211> 47
<212> DNA
<213> Streptomyces virginiae

<400> 4
tgtcacttgt acatcgtata actctcatat acgttgtaga acagttc                     47


<210> 5
<211> 79
<212> DNA
<213> Bacillus subtilis

<400> 5
ctttctccta caattatata gaacggtcta gacaaatgaa tgataatata tagactggtc       60

taaattggag gaagcgata                                                    79


<210> 6
<211> 28
<212> DNA
<213> Staphylococcus epidermidis

<400> 6
acaacctaac taacgaaagg taggtgaa                                          28


<210> 7
<211> 55
<212> DNA
<213> Mycobacterium tuberculosis

<400> 7
gtgtcgatag tgtcgacatc tcgttgacgg cctcgacatt acgttgatag cgtgg            55


<210> 8
<211> 35
<212> DNA
<213> Pseudomonas putida

<400> 8
aagaaagaaa caaaccaacc tgtctgtatt atctc                                  35


<210> 9
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
atggctagaa ccccatctcg atcttctatc ggttctttgc gatctccaca cacccacaag       60

gctatcttga cctctaccat cgaaatcttg aaggaatgtg gttactctgg tttgtctatc      120

gaatctgttg ctagaagagc tggtgcttct aagccaacca tctacagatg gtggaccaac      180

aaggctgctt tgatcgctga agtttacgaa aacgaatctg aacaagttag aaagttccca      240

gacttgggtt ctttcaaggc tgacttggac ttcttgttga gaaacttgtg gaaggtttgg      300

agagaaacca tctgtggtga ggctttcaga tgtgttatcg ctgaagctca attggaccca      360

gctaccttga cccaattgaa ggaccaattc atggaaagaa gaagagaaat gccaaagaag      420

ttggttgaaa acgctatctc taacggtgaa ttgccaaagg acaccaacag agaattgttg      480

ttggacatga tcttcggttt ctgttggtac agattgttga ccgaacaatt gaccgttgaa      540

caagacatcg aagagttcac cttcttgttg atcaacggtg tttgtccagg aacccaaaga      600

gggccggccg acgctttgga cgacttcgac ttggacatgt tgcctgcaga tgcacttgat      660

gattttgatc ttgatatgct tccagcagac gcattggatg actttgacct tgacatgctt      720

cctggttga                                                              729


<210> 10
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Ala Arg Thr Pro Ser Arg Ser Ser Ile Gly Ser Leu Arg Ser Pro 
1               5                   10                  15      


His Thr His Lys Ala Ile Leu Thr Ser Thr Ile Glu Ile Leu Lys Glu 
            20                  25                  30          


Cys Gly Tyr Ser Gly Leu Ser Ile Glu Ser Val Ala Arg Arg Ala Gly 
        35                  40                  45              


Ala Ser Lys Pro Thr Ile Tyr Arg Trp Trp Thr Asn Lys Ala Ala Leu 
    50                  55                  60                  


Ile Ala Glu Val Tyr Glu Asn Glu Ser Glu Gln Val Arg Lys Phe Pro 
65                  70                  75                  80  


Asp Leu Gly Ser Phe Lys Ala Asp Leu Asp Phe Leu Leu Arg Asn Leu 
                85                  90                  95      


Trp Lys Val Trp Arg Glu Thr Ile Cys Gly Glu Ala Phe Arg Cys Val 
            100                 105                 110         


Ile Ala Glu Ala Gln Leu Asp Pro Ala Thr Leu Thr Gln Leu Lys Asp 
        115                 120                 125             


Gln Phe Met Glu Arg Arg Arg Glu Met Pro Lys Lys Leu Val Glu Asn 
    130                 135                 140                 


Ala Ile Ser Asn Gly Glu Leu Pro Lys Asp Thr Asn Arg Glu Leu Leu 
145                 150                 155                 160 


Leu Asp Met Ile Phe Gly Phe Cys Trp Tyr Arg Leu Leu Thr Glu Gln 
                165                 170                 175     


Leu Thr Val Glu Gln Asp Ile Glu Glu Phe Thr Phe Leu Leu Ile Asn 
            180                 185                 190         


Gly Val Cys Pro Gly Thr Gln Arg Gly Pro Ala Asp Ala Leu Asp Asp 
        195                 200                 205             


Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu 
    210                 215                 220                 


Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
225                 230                 235                 240 


Pro Gly 
        


<210> 11
<211> 624
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
atgccaaaga agaagagaaa ggttgctaga accccatctc gatcttctat cggttctttg       60

cgatctccac acacccacaa ggctatcttg acctctacca tcgaaatctt gaaggaatgt      120

ggttactctg gtttgtctat cgaatctgtt gctagaagag ctggtgcttc taagccaacc      180

atctacagat ggtggaccaa caaggctgct ttgatcgctg aagtttacga aaacgaatct      240

gaacaagtta gaaagttccc agacttgggt tctttcaagg ctgacttgga cttcttgttg      300

agaaacttgt ggaaggtttg gagagaaacc atctgtggtg aggctttcag atgtgttatc      360

gctgaagctc aattggaccc agctaccttg acccaattga aggaccaatt catggaaaga      420

agaagagaaa tgccaaagaa gttggttgaa aacgctatct ctaacggtga attgccaaag      480

gacaccaaca gagaattgtt gttggacatg atcttcggtt tctgttggta cagattgttg      540

accgaacaat tgaccgttga acaagacatc gaagagttca ccttcttgtt gatcaacggt      600

gtttgtccag gaacccaaag atga                                             624


<210> 12
<211> 207
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Pro Lys Lys Lys Arg Lys Val Ala Arg Thr Pro Ser Arg Ser Ser 
1               5                   10                  15      


Ile Gly Ser Leu Arg Ser Pro His Thr His Lys Ala Ile Leu Thr Ser 
            20                  25                  30          


Thr Ile Glu Ile Leu Lys Glu Cys Gly Tyr Ser Gly Leu Ser Ile Glu 
        35                  40                  45              


Ser Val Ala Arg Arg Ala Gly Ala Ser Lys Pro Thr Ile Tyr Arg Trp 
    50                  55                  60                  


Trp Thr Asn Lys Ala Ala Leu Ile Ala Glu Val Tyr Glu Asn Glu Ser 
65                  70                  75                  80  


Glu Gln Val Arg Lys Phe Pro Asp Leu Gly Ser Phe Lys Ala Asp Leu 
                85                  90                  95      


Asp Phe Leu Leu Arg Asn Leu Trp Lys Val Trp Arg Glu Thr Ile Cys 
            100                 105                 110         


Gly Glu Ala Phe Arg Cys Val Ile Ala Glu Ala Gln Leu Asp Pro Ala 
        115                 120                 125             


Thr Leu Thr Gln Leu Lys Asp Gln Phe Met Glu Arg Arg Arg Glu Met 
    130                 135                 140                 


Pro Lys Lys Leu Val Glu Asn Ala Ile Ser Asn Gly Glu Leu Pro Lys 
145                 150                 155                 160 


Asp Thr Asn Arg Glu Leu Leu Leu Asp Met Ile Phe Gly Phe Cys Trp 
                165                 170                 175     


Tyr Arg Leu Leu Thr Glu Gln Leu Thr Val Glu Gln Asp Ile Glu Glu 
            180                 185                 190         


Phe Thr Phe Leu Leu Ile Asn Gly Val Cys Pro Gly Thr Gln Arg 
        195                 200                 205         


<210> 13
<211> 653
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
cacttctaaa taagcgaatt tcttatgatt tatgattttt attattaaat aagttataaa       60

aaaaataagt gtatacaaat tttaaagtga ctcttaggtt ttaaaacgaa aattcttgtt      120

cttgagtaac tctttcctgt aggtcaggtt gctttctcag gtatagcatg aggtcgctct      180

tattgaccac acctctaccg gcaggccggc ccggtatgta tgatacgaaa cgtaccgtat      240

cgttaaggta gcgttatgta tgatacgaaa cgtaccgtat cgttaaggta gcgttatgta      300

tgatacgaaa cgtaccgtat cgttaaggta gcgttatgta tgatacgaaa cgtaccgtat      360

cgttaaggta gcgttatgta tgatacgaaa cgtaccgtat cgttaaggta gcgttatgta      420

tgatacgaaa cgtaccgtat cgttaaggta gcgttatgta tgatacgaaa cgtaccgtat      480

cgttaaggta gcgtcccggg ccggcctatg gcatgcatgt gctctgtatg tatataaaac      540

tcttgttttc ttcttttctc taaatattct ttccttatac attaggtcct ttgtagcata      600

aattactata cttctataga cacgcaaaca caaatacaca cactaaatta ata             653


<210> 14
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
atgatacgaa acgtaccgta tcgttaaggt                                        30


<210> 15
<211> 823
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
taaagtccaa tgctagtaga gaaggggggt aacacccctc cgcgctcttt tccgattttt       60

ttctaaaccg tggaatattt cggatatcct tttgttgttt ccgggtgtac aatatggact      120

tcctcttttc tggcaaccaa acccatacat cgggattcct ataatacctt cgttggtcac      180

cctaacatgt aggtggcgga ggggagatat acaatagaac agataccaga caagacataa      240

tgggctaaac aagactacac caattacact gcctcattga tggtggtaca taacgaacta      300

atactgtagc cctagacttg atagccatca tcatatcgaa gtttcactac cctttttcca      360

tttgccatct attgaagtaa taataggcgc atgcaacttc ttttcttttt ttttcttttc      420

tctctccccc gttgttgtct caccatatcc gcaatgacaa aaaaatgatg gaagacacta      480

aaggaaaaaa ttaacgacaa agacagcacc aacagatgtc gttgttccag agctgatgag      540

gggtatctcg aagcacacga aactttttcc ttccttcatt cacgcacact actctctaat      600

gagcaacggt atacggcctt ccttccagtt acttgaattt gaaataaaaa aaagtttgct      660

gtcttgctat caagtataaa tagacctgca attatgtatg atacgaaacg taccgtatcg      720

ttaaggtagc gtatgatacg aaacgtaccg tatcgttaag gtagcgtctt tcttccttgt      780

ttctttttct gcaggtcgac tctagaggat ccccgggtat taa                        823


<210> 16
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 16
atgatacgaa acgtaccgta tcgttaaggt agcgt                                  35


<210> 17
<211> 762
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
atgccaaaga agaagagaaa ggtaatgtct ccaaagagaa gaactcaagc tgaaagagct       60

atggaaactc aaggtaagtt gatcgctgct gctttgggtg ttttgagaga aaagggttac      120

gctggtttca gaatcgctga cgttccaggt gctgctggtg tttctagagg tgctcaatct      180

caccacttcc caaccaagtt ggaattgttg ttggctacct tcgaatggtt gtacgaacaa      240

atcaccgaaa gatctagagc tagattggct aagttgaagc cagaagacga cgttatccaa      300

caaatgttgg acgacgctgc tgaattcttc ttggacgacg acttctctat ctctttggac      360

ttgatcgttg ctgctgaccg cgatcctgct ttgagagaag gtatccaaag aaccgttgaa      420

agaaacagat tcgttgttga agacatgtgg ttgggtgttt tggtttctag aggtttgtct      480

cgcgacgacg ctgaagacat cttgtggttg atcttcaact ctgttagagg tttggctgtt      540

agatctttgt ggcaaaagga caaggaaaga ttcgaaagag ttagaaactc taccttggaa      600

atcgctagag aaagatacgc taagttcaag agggggccgg ccgacgcttt ggacgacttc      660

gacttggaca tgttgcctgc agatgcactt gatgattttg atcttgatat gcttccagca      720

gacgcattgg atgactttga ccttgacatg cttcctggtt ga                         762


<210> 18
<211> 253
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Pro Lys Lys Lys Arg Lys Val Met Ser Pro Lys Arg Arg Thr Gln 
1               5                   10                  15      


Ala Glu Arg Ala Met Glu Thr Gln Gly Lys Leu Ile Ala Ala Ala Leu 
            20                  25                  30          


Gly Val Leu Arg Glu Lys Gly Tyr Ala Gly Phe Arg Ile Ala Asp Val 
        35                  40                  45              


Pro Gly Ala Ala Gly Val Ser Arg Gly Ala Gln Ser His His Phe Pro 
    50                  55                  60                  


Thr Lys Leu Glu Leu Leu Leu Ala Thr Phe Glu Trp Leu Tyr Glu Gln 
65                  70                  75                  80  


Ile Thr Glu Arg Ser Arg Ala Arg Leu Ala Lys Leu Lys Pro Glu Asp 
                85                  90                  95      


Asp Val Ile Gln Gln Met Leu Asp Asp Ala Ala Glu Phe Phe Leu Asp 
            100                 105                 110         


Asp Asp Phe Ser Ile Ser Leu Asp Leu Ile Val Ala Ala Asp Arg Asp 
        115                 120                 125             


Pro Ala Leu Arg Glu Gly Ile Gln Arg Thr Val Glu Arg Asn Arg Phe 
    130                 135                 140                 


Val Val Glu Asp Met Trp Leu Gly Val Leu Val Ser Arg Gly Leu Ser 
145                 150                 155                 160 


Arg Asp Asp Ala Glu Asp Ile Leu Trp Leu Ile Phe Asn Ser Val Arg 
                165                 170                 175     


Gly Leu Ala Val Arg Ser Leu Trp Gln Lys Asp Lys Glu Arg Phe Glu 
            180                 185                 190         


Arg Val Arg Asn Ser Thr Leu Glu Ile Ala Arg Glu Arg Tyr Ala Lys 
        195                 200                 205             


Phe Lys Arg Gly Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
    210                 215                 220                 


Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala 
225                 230                 235                 240 


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Gly 
                245                 250             


<210> 19
<211> 564
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 19
cacttctaaa taagcgaatt tcttatgatt tatgattttt attattaaat aagttataaa       60

aaaaataagt gtatacaaat tttaaagtga ctcttaggtt ttaaaacgaa aattcttgtt      120

cttgagtaac tctttcctgt aggtcaggtt gctttctcag gtatagcatg aggtcgctct      180

tattgaccac acctctaccg gcaaggtaag aaagaaacaa accaacctgt ctgtattatc      240

tcaagaaaga aacaaaccaa cctgtctgta ttatctcaag aaagaaacaa accaacctgt      300

ctgtattatc tcaagaaaga aacaaaccaa cctgtctgta ttatctcaag aaagaaacaa      360

accaacctgt ctgtattatc tcaagaaaga aacaaaccaa cctgtctgta ttatctcaat      420

ggcatgcatg tgctctgtat gtatataaaa ctcttgtttt cttcttttct ctaaatattc      480

tttccttata cattaggtcc tttgtagcat aaattactat acttctatag acacgcaaac      540

acaaatacac acactaaatt aata                                             564


<210> 20
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
agaaacaaac caacctgtct gtatta                                            26


<210> 21
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 21
aacaaacaga caatctggtc tgtttgta                                          28


<210> 22
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 22
atgagtagat tggacaagtc taaggttatc aactctgctt tggaattgtt gaacgaagtt       60

ggtatcgaag gtttgaccac cagaaagttg gctcaaaagt tgggtgttga acaaccaacc      120

ttgtactggc acgttaagaa caagagagct ttgttggacg ctttggctat cgaaatgttg      180

gacagacacc acacccactt ctgtccattg gaaggtgaat cttggcaaga cttcttgaga      240

aacaacgcta agtctttcag atgtgctttg ctctctcacc gcgacggtgc taaggttcac      300

ttgggaacca gaccaaccga aaagcaatac gaaaccttgg aaaaccaatt ggctttcttg      360

tgtcaacaag gtttctcttt ggaaaacgct ttgtacgctt tgtctgctgt tggtcacttc      420

accttgggtt gtgttttgga agaccaagaa caccaagttg ctaaggaaga aagagaaacc      480

ccaaccaccg actctatgcc accattgctc agacaagcta tcgaattgtt cgaccaccaa      540

ggtgctgaac cagctttctt gttcggtttg gaattgatca tctgtggttt ggaaaagcaa      600

ttgaagtgtg aatctggtgg gccggccgac gctttggacg acttcgactt ggacatgttg      660

ccagctgacg ctttggacga cttcgacttg gacatgttgc cagctgacgc tttggacgac      720

ttcgacttgg acatgttgcc aggttga                                          747


<210> 23
<211> 248
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Ser Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Glu Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Ala Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Asp Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp His Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro 
        195                 200                 205             


Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala 
    210                 215                 220                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp 
225                 230                 235                 240 


Phe Asp Leu Asp Met Leu Pro Gly 
                245             


<210> 24
<211> 667
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 24
cacttctaaa taagcgaatt tcttatgatt tatgattttt attattaaat aagttataaa       60

aaaaataagt gtatacaaat tttaaagtga ctcttaggtt ttaaaacgaa aattcttgtt      120

cttgagtaac tctttcctgt aggtcaggtt gctttctcag gtatagcatg aggtcgctct      180

tattgaccac acctctaccg gcaggccggc ccgggtcgag tttaccactc cctatcagtg      240

atagagaaaa gtgaaagtcg agtttaccac tccctatcag tgatagagaa aagtgaaagt      300

cgagtttacc actccctatc agtgatagag aaaagtgaaa gtcgagttta ccactcccta      360

tcagtgatag agaaaagtga aagtcgagtt taccactccc tatcagtgat agagaaaagt      420

gaaagtcgag tttaccactc cctatcagtg atagagaaaa gtgaaagtcg agtttaccac      480

tccctatcag tgatagagaa aagtgaaacc cgggccggcc tatggcatgc atgtgctctg      540

tatgtatata aaactcttgt tttcttcttt tctctaaata ttctttcctt atacattagg      600

tcctttgtag cataaattac tatacttcta tagacacgca aacacaaata cacacactaa      660

attaata                                                                667


<210> 25
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 25
atggacatca agcaatcttt gttgcacgct gctatgagat tgttgtctgc taagggtcgc       60

gacggtgcta ccatgcgacc aatctgtgct gaagttggtg ttaccccacc aaccttgtac      120

caccactacg gtgacttgca aggtttgcac aaggctgcta tcgacgaaac ctacagacaa      180

gttgctgaag cttaccacgg tggtaccgaa gaaagaggtc cattgaaggg tatccgcgac      240

ggttgggcta ccttcttgca attcgcttac tctgaaccaa acatgtgtag aatgttggtt      300

caacacatca tggctggtga accaccatct atggttgctg acaccttgag aggtgttgct      360

gacgacttgg ctcaattcca cgctcaaggt agattgacct tcccaccaag agaagctgct      420

caattgttgt ggatgggtgc tttgggtgct ttgacctacg ctttgtctag agaaggtgct      480

ggttacaccc aagacttggc tttgcaaaag gctaagttgg acatcacctt ggttgctttg      540

ttcaacatcg aagaagaagg gccggccgac gctttggacg acttcgactt ggacatgttg      600

cctgcagatg cacttgatga ttttgatctt gatatgcttc cagcagacgc attggatgac      660

tttgaccttg acatgcttcc tggtatgcca aagaagaaga gaaaggtatg a               711


<210> 26
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Met Asp Ile Lys Gln Ser Leu Leu His Ala Ala Met Arg Leu Leu Ser 
1               5                   10                  15      


Ala Lys Gly Arg Asp Gly Ala Thr Met Arg Pro Ile Cys Ala Glu Val 
            20                  25                  30          


Gly Val Thr Pro Pro Thr Leu Tyr His His Tyr Gly Asp Leu Gln Gly 
        35                  40                  45              


Leu His Lys Ala Ala Ile Asp Glu Thr Tyr Arg Gln Val Ala Glu Ala 
    50                  55                  60                  


Tyr His Gly Gly Thr Glu Glu Arg Gly Pro Leu Lys Gly Ile Arg Asp 
65                  70                  75                  80  


Gly Trp Ala Thr Phe Leu Gln Phe Ala Tyr Ser Glu Pro Asn Met Cys 
                85                  90                  95      


Arg Met Leu Val Gln His Ile Met Ala Gly Glu Pro Pro Ser Met Val 
            100                 105                 110         


Ala Asp Thr Leu Arg Gly Val Ala Asp Asp Leu Ala Gln Phe His Ala 
        115                 120                 125             


Gln Gly Arg Leu Thr Phe Pro Pro Arg Glu Ala Ala Gln Leu Leu Trp 
    130                 135                 140                 


Met Gly Ala Leu Gly Ala Leu Thr Tyr Ala Leu Ser Arg Glu Gly Ala 
145                 150                 155                 160 


Gly Tyr Thr Gln Asp Leu Ala Leu Gln Lys Ala Lys Leu Asp Ile Thr 
                165                 170                 175     


Leu Val Ala Leu Phe Asn Ile Glu Glu Glu Gly Pro Ala Asp Ala Leu 
            180                 185                 190         


Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe 
        195                 200                 205             


Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
    210                 215                 220                 


Met Leu Pro Gly Met Pro Lys Lys Lys Arg Lys Val 
225                 230                 235     


<210> 27
<211> 577
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 27
cacttctaaa taagcgaatt tcttatgatt tatgattttt attattaaat aagttataaa       60

aaaaataagt gtatacaaat tttaaagtga ctcttaggtt ttaaaacgaa aattcttgtt      120

cttgagtaac tctttcctgt aggtcaggtt gctttctcag gtatagcatg aggtcgctct      180

tattgaccac acctctaccg gcaaggtcag gctctatatc tgcgatatac tgagcatatc      240

ccccccaggc tctatatctg cgatatactg agcatatccc ccccaggctc tatatctgcg      300

atatactgag catatccccc ccaggctcta tatctgcgat atactgagca tatcccccca      360

ggctctatat ctgcgatata ctgagcatat ccccccaggc tctatatctg cgatatactg      420

agcatatccc aatggcatgc atgtgctctg tatgtatata aaactcttgt tttcttcttt      480

tctctaaata ttctttcctt atacattagg tcctttgtag cataaattac tatacttcta      540

tagacacgca aacacaaata cacacactaa attaata                               577


<210> 28
<211> 747
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
atgagtagat tggacaagtc taaggttatc aacggtgctt tggaattgtt gaacggtgtt       60

ggtatcgaag gtttgaccac cagaaagttg gctcaaaagt tgggtgttga acaaccaacc      120

ttgtactggc acgttaagaa caagagagct ttgttggacg ctttgccaat cgaaatgttg      180

gacagacacc acacccactt ctgtccattg gaaggtgaat cttggcaaga cttcttgaga      240

aacaacgcta agtctttcag atgtgctttg ctctctcacc gcgacggtgc taaggttcac      300

ttgggaacca gaccaaccga aaagcaatac gaaaccttgg aaaaccaatt ggctttcttg      360

tgtcaacaag gtttctcttt ggaaaacgct ttgtacgctt tgtctgctgt tggtcacttc      420

accttgggtt gtgttttgga agaacaagaa caccaagttg ctaaggaaga aagagaaacc      480

ccaaccaccg actctatgcc accattgctc agacaagcta tcgaattgtt cgacagacaa      540

ggtgctgaac cagctttctt gttcggtttg gaattgatca tctgtggttt ggaaaagcaa      600

ttgaagtgtg aatctggtgg gccggccgac gctttggacg acttcgactt ggacatgttg      660

ccagctgacg ctttggacga cttcgacttg gacatgttgc cagctgacgc tttggacgac      720

ttcgacttgg acatgttgcc aggttga                                          747


<210> 29
<211> 248
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Met Ser Arg Leu Asp Lys Ser Lys Val Ile Asn Gly Ala Leu Glu Leu 
1               5                   10                  15      


Leu Asn Gly Val Gly Ile Glu Gly Leu Thr Thr Arg Lys Leu Ala Gln 
            20                  25                  30          


Lys Leu Gly Val Glu Gln Pro Thr Leu Tyr Trp His Val Lys Asn Lys 
        35                  40                  45              


Arg Ala Leu Leu Asp Ala Leu Pro Ile Glu Met Leu Asp Arg His His 
    50                  55                  60                  


Thr His Phe Cys Pro Leu Glu Gly Glu Ser Trp Gln Asp Phe Leu Arg 
65                  70                  75                  80  


Asn Asn Ala Lys Ser Phe Arg Cys Ala Leu Leu Ser His Arg Asp Gly 
                85                  90                  95      


Ala Lys Val His Leu Gly Thr Arg Pro Thr Glu Lys Gln Tyr Glu Thr 
            100                 105                 110         


Leu Glu Asn Gln Leu Ala Phe Leu Cys Gln Gln Gly Phe Ser Leu Glu 
        115                 120                 125             


Asn Ala Leu Tyr Ala Leu Ser Ala Val Gly His Phe Thr Leu Gly Cys 
    130                 135                 140                 


Val Leu Glu Glu Gln Glu His Gln Val Ala Lys Glu Glu Arg Glu Thr 
145                 150                 155                 160 


Pro Thr Thr Asp Ser Met Pro Pro Leu Leu Arg Gln Ala Ile Glu Leu 
                165                 170                 175     


Phe Asp Arg Gln Gly Ala Glu Pro Ala Phe Leu Phe Gly Leu Glu Leu 
            180                 185                 190         


Ile Ile Cys Gly Leu Glu Lys Gln Leu Lys Cys Glu Ser Gly Gly Pro 
        195                 200                 205             


Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala 
    210                 215                 220                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Pro Ala Asp Ala Leu Asp Asp 
225                 230                 235                 240 


Phe Asp Leu Asp Met Leu Pro Gly 
                245             


<210> 30
<211> 881
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 30
ggtctcacag tctcgatgga ttagtttctc acaggtaaca taacaaaaac caagaaaagc       60

ccgcttctga aaactacagt tgacttgtat gctaaagggc cagactaatg ggaggagaaa      120

aagaaacgaa tgtatatgct catttacact ctatatcacc atatggagga taagttgggc      180

tgagcttctg atccaattta ttctatccat tagttgctga tatgtcccac cagccaacac      240

ttgatagtat ctactcgcca ttcacttcca gcagcgccag tagggttgtt gagcttagta      300

aaaatgtgcg caccacaagc ctacatgact ccacgtcaca tgaaaccaca ccgtggggcc      360

ttgttgcgct aggaatagga tatgcgacga agacgcttct gcttagtaac cacaccacat      420

tttcaggggg tcgatctgct tgcttccttt actgtcacga gcggcccata atcgcgcttt      480

ttttttaaaa ggcgcgagac agcaaacagg aagctcgggt ttcaaccttc ggagtggtcg      540

cagatctgga gactggatct ttacaataca gtaaggcaag ccaccatctg cttcttaggt      600

gcatgcgacg gtatccacgt gcagaacaac atagtctgaa gaaggggggg aggagcatgt      660

tcattctctg tagcagtaag agcttggtga taatgaccaa aactggagtc tcgaaatcat      720

ataaatagac aatatatttt cacacaatga gatttgtagt acagttctat tctctctctt      780

gcataaataa gaaattcatc aagaacttgg tttgatattt caccaacaca cacaaaaaac      840

agtacttcac taaatttaca cacaaaacaa aatgagagac c                          881


<210> 31
<211> 792
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
ggtctcacag tgagcttggc ccattgcata cgttgtatcc atatcataat atgtacattt       60

atattggctc atgtccaaca ttaccgccat gttgacattg attattgact agttattaat      120

agtaatcaat tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac      180

ttacggtaaa tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa      240

tgacgtatgt tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt      300

atttacggta aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc      360

ctattgacgt caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat      420

gggactttcc tacttggcag tacatctacg tattagtcat cgctattacc atggtgatgc      480

ggttttggca gtacatcaat gggcgtggat agcggtttga ctcacgggga tttccaagtc      540

tccaccccat tgacgtcaat gggagtttgt tttggcacca aaatcaacgg gactttccaa      600

aatgtcgtaa caactccgcc ccattgacgc aaatgggcgg taggcgtgta cggtgggagg      660

tctatataag cagagctcgt ttagtgaacc gtcagatcgc ctgtagacgc catccacgct      720

gttttgacct ccatagaaga caccgggacc gatccagcct ccgcggcccg aattaattca      780

taatgagaga cc                                                          792


<210> 32
<211> 725
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 32
ggtctcgtga gactcctttt acttcggttg tgaaagaaag ttgacattat cgatttgggt       60

gacacggtga ttgaaaaagc aacgaccagt attatacctc ttttttttat tattcagttt      120

atatttttgc aagtgatctt aagcatttct acacaaactt atgccaacgt gaccatttat      180

tattttatat agcaaaaaaa aatgaggggc cttgcagaac aattgttgcg agtttctaat      240

aacaagcacg tagaatattg gccatttaat ttttctcttc aatttataga atggttgtgt      300

tagtgacaaa aagaatattc ttccccgcca ggactcgaac ctggaatctc ctggttcgta      360

gccagacgcc gtgaccattg ggccacgagg aacaagaata taaagatctc tgagggcaag      420

gtatgcctat gtcgcaataa aatgtttgtt cctgcgcaaa agtaaagttc tattaatata      480

caactacaca gttatcggtt cacactattc gatagttgta aaaaccattt tgataaagat      540

ataacaaggc gtttattaag gacatttttg ctacaagtcg tgaagtattg attgtaggcg      600

atcgttggta actttctcca tatcggaata ttcaatattg aactcacccc tcccttgcga      660

taagctcctt agcttattgg tgtaggtggt aatttccctt agtggcactt tcgcttttcg      720

agacc                                                                  725


<210> 33
<211> 748
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
ggtctcgtga gtcgccagtg ccatgtttct gccttcgacc ggaccttttt aagtacgata       60

aatatccttt tataaatata tagtctaaaa tatccattaa tactgtgctc aatcaatcgt      120

gttagatgat ttagtttttt ccaaatcgtt attatagtgc agaagtagta tacataaagg      180

catatgcatg cgatttggaa gtaacgctcg ccgtagacaa gtaagaatgc ctgctgtctt      240

gagaaccagg tccaaagaat cctctataga gcagaagcct gcttccagaa ctagaacgag      300

atcaagaagg ggcaagcgtg gtcgtgacga tgatgatgat gacgacgatg aggaaagcga      360

tgatgcatac gatgaagtag gtaatgacta tgacgagtat gcttcaagag cgaagctggc      420

caccaatagg cccttcgaaa tagtcgcggg actgcctgct agtgtggagc tgcccaacta      480

taactcttcg cttactcatc cgcaatcaat taaaaattct ggggtgcttt acgactctct      540

ggtcagttcc agaagaacct gggttcaggg tgagatgttt gaactgtatt ggcgaagacc      600

taagaaaatt gttagtgaat ctaccccagc agcgacggag agtccaacat ctggaacgat      660

tcctttgatt cgagataaga tgcagaaaat gtgcgattgt gtaatgagtg gaggtcctca      720

cacgttcaaa gttagacttt tggagacc                                         748


<210> 34
<211> 573
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 34
ggtctcatga gaaaagacac acatgcgagc tttcgaacct cagatgctaa tattacgtgt       60

tatatatacc aaactttata aaatgacata gatattttat gctgtgatag ctttcctgtt      120

atggagaagc tcttcttatt ccccctgtca actttcatac tcttgtagaa tttcctttat      180

gataggttta tcgcttacga atttagactt tgatgtgatg ggtttggcac ctgttctttt      240

tccacaacct ttgcgtgcct catcaatagc gtttgatctg tcgggaaatt tgtatttgta      300

gagtgcatcc ttgcacattg tatagaccca attacgctct tctaacaggt tcacgaacga      360

ttttatttca ggaacagagc cgattgtact ttttgaacct ataatgatca gcttggattt      420

ggcccttgtc atggcaacat tgactcttct tagctctttc agcagcgctc ctccatttaa      480

ttgagaattt cttctaacca tggaaataat aatgcacttt ttgtcacgac cttgaaactg      540

atcagcagtc aagatctcta gcttttagag acc                                   573


<210> 35
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
atgccaaaga agaagagaaa ggtt                                              24


<210> 36
<211> 18
<212> DNA
<213> Mycobacterium sp.

<400> 36
aagatgaccg gtcacctt                                                     18


