                         SEQUENCE LISTING

<110>  Wageningen Universiteit & Stichting voor de Technische Wetenschappen
 
<120>  THERMOSTABLE CAS9 NUCLEASES

<130>  P220294WO3

<150>  PCT/EP2016/081077
<151>  2016-12-14

<160>  170   

<170>  PatentIn version 3.5

<210>  1
<211>  1082
<212>  PRT
<213>  Geobacillus thermodenitrificans T12

<400>  1

Met Lys Tyr Lys Ile Gly Leu Asp Ile Gly Ile Thr Ser Ile Gly Trp 
1               5                   10                  15      


Ala Val Ile Asn Leu Asp Ile Pro Arg Ile Glu Asp Leu Gly Val Arg 
            20                  25                  30          


Ile Phe Asp Arg Ala Glu Asn Pro Lys Thr Gly Glu Ser Leu Ala Leu 
        35                  40                  45              


Pro Arg Arg Leu Ala Arg Ser Ala Arg Arg Arg Leu Arg Arg Arg Lys 
    50                  55                  60                  


His Arg Leu Glu Arg Ile Arg Arg Leu Phe Val Arg Glu Gly Ile Leu 
65                  70                  75                  80  


Thr Lys Glu Glu Leu Asn Lys Leu Phe Glu Lys Lys His Glu Ile Asp 
                85                  90                  95      


Val Trp Gln Leu Arg Val Glu Ala Leu Asp Arg Lys Leu Asn Asn Asp 
            100                 105                 110         


Glu Leu Ala Arg Ile Leu Leu His Leu Ala Lys Arg Arg Gly Phe Arg 
        115                 120                 125             


Ser Asn Arg Lys Ser Glu Arg Thr Asn Lys Glu Asn Ser Thr Met Leu 
    130                 135                 140                 


Lys His Ile Glu Glu Asn Gln Ser Ile Leu Ser Ser Tyr Arg Thr Val 
145                 150                 155                 160 


Ala Glu Met Val Val Lys Asp Pro Lys Phe Ser Leu His Lys Arg Asn 
                165                 170                 175     


Lys Glu Asp Asn Tyr Thr Asn Thr Val Ala Arg Asp Asp Leu Glu Arg 
            180                 185                 190         


Glu Ile Lys Leu Ile Phe Ala Lys Gln Arg Glu Tyr Gly Asn Ile Val 
        195                 200                 205             


Cys Thr Glu Ala Phe Glu His Glu Tyr Ile Ser Ile Trp Ala Ser Gln 
    210                 215                 220                 


Arg Pro Phe Ala Ser Lys Asp Asp Ile Glu Lys Lys Val Gly Phe Cys 
225                 230                 235                 240 


Thr Phe Glu Pro Lys Glu Lys Arg Ala Pro Lys Ala Thr Tyr Thr Phe 
                245                 250                 255     


Gln Ser Phe Thr Val Trp Glu His Ile Asn Lys Leu Arg Leu Val Ser 
            260                 265                 270         


Pro Gly Gly Ile Arg Ala Leu Thr Asp Asp Glu Arg Arg Leu Ile Tyr 
        275                 280                 285             


Lys Gln Ala Phe His Lys Asn Lys Ile Thr Phe His Asp Val Arg Thr 
    290                 295                 300                 


Leu Leu Asn Leu Pro Asp Asp Thr Arg Phe Lys Gly Leu Leu Tyr Asp 
305                 310                 315                 320 


Arg Asn Thr Thr Leu Lys Glu Asn Glu Lys Val Arg Phe Leu Glu Leu 
                325                 330                 335     


Gly Ala Tyr His Lys Ile Arg Lys Ala Ile Asp Ser Val Tyr Gly Lys 
            340                 345                 350         


Gly Ala Ala Lys Ser Phe Arg Pro Ile Asp Phe Asp Thr Phe Gly Tyr 
        355                 360                 365             


Ala Leu Thr Met Phe Lys Asp Asp Thr Asp Ile Arg Ser Tyr Leu Arg 
    370                 375                 380                 


Asn Glu Tyr Glu Gln Asn Gly Lys Arg Met Glu Asn Leu Ala Asp Lys 
385                 390                 395                 400 


Val Tyr Asp Glu Glu Leu Ile Glu Glu Leu Leu Asn Leu Ser Phe Ser 
                405                 410                 415     


Lys Phe Gly His Leu Ser Leu Lys Ala Leu Arg Asn Ile Leu Pro Tyr 
            420                 425                 430         


Met Glu Gln Gly Glu Val Tyr Ser Thr Ala Cys Glu Arg Ala Gly Tyr 
        435                 440                 445             


Thr Phe Thr Gly Pro Lys Lys Lys Gln Lys Thr Val Leu Leu Pro Asn 
    450                 455                 460                 


Ile Pro Pro Ile Ala Asn Pro Val Val Met Arg Ala Leu Thr Gln Ala 
465                 470                 475                 480 


Arg Lys Val Val Asn Ala Ile Ile Lys Lys Tyr Gly Ser Pro Val Ser 
                485                 490                 495     


Ile His Ile Glu Leu Ala Arg Glu Leu Ser Gln Ser Phe Asp Glu Arg 
            500                 505                 510         


Arg Lys Met Gln Lys Glu Gln Glu Gly Asn Arg Lys Lys Asn Glu Thr 
        515                 520                 525             


Ala Ile Arg Gln Leu Val Glu Tyr Gly Leu Thr Leu Asn Pro Thr Gly 
    530                 535                 540                 


Leu Asp Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Asn Gly Lys Cys 
545                 550                 555                 560 


Ala Tyr Ser Leu Gln Pro Ile Glu Ile Glu Arg Leu Leu Glu Pro Gly 
                565                 570                 575     


Tyr Thr Glu Val Asp His Val Ile Pro Tyr Ser Arg Ser Leu Asp Asp 
            580                 585                 590         


Ser Tyr Thr Asn Lys Val Leu Val Leu Thr Lys Glu Asn Arg Glu Lys 
        595                 600                 605             


Gly Asn Arg Thr Pro Ala Glu Tyr Leu Gly Leu Gly Ser Glu Arg Trp 
    610                 615                 620                 


Gln Gln Phe Glu Thr Phe Val Leu Thr Asn Lys Gln Phe Ser Lys Lys 
625                 630                 635                 640 


Lys Arg Asp Arg Leu Leu Arg Leu His Tyr Asp Glu Asn Glu Glu Asn 
                645                 650                 655     


Glu Phe Lys Asn Arg Asn Leu Asn Asp Thr Arg Tyr Ile Ser Arg Phe 
            660                 665                 670         


Leu Ala Asn Phe Ile Arg Glu His Leu Lys Phe Ala Asp Ser Asp Asp 
        675                 680                 685             


Lys Gln Lys Val Tyr Thr Val Asn Gly Arg Ile Thr Ala His Leu Arg 
    690                 695                 700                 


Ser Arg Trp Asn Phe Asn Lys Asn Arg Glu Glu Ser Asn Leu His His 
705                 710                 715                 720 


Ala Val Asp Ala Ala Ile Val Ala Cys Thr Thr Pro Ser Asp Ile Ala 
                725                 730                 735     


Arg Val Thr Ala Phe Tyr Gln Arg Arg Glu Gln Asn Lys Glu Leu Ser 
            740                 745                 750         


Lys Lys Thr Asp Pro Gln Phe Pro Gln Pro Trp Pro His Phe Ala Asp 
        755                 760                 765             


Glu Leu Gln Ala Arg Leu Ser Lys Asn Pro Lys Glu Ser Ile Lys Ala 
    770                 775                 780                 


Leu Asn Leu Gly Asn Tyr Asp Asn Glu Lys Leu Glu Ser Leu Gln Pro 
785                 790                 795                 800 


Val Phe Val Ser Arg Met Pro Lys Arg Ser Ile Thr Gly Ala Ala His 
                805                 810                 815     


Gln Glu Thr Leu Arg Arg Tyr Ile Gly Ile Asp Glu Arg Ser Gly Lys 
            820                 825                 830         


Ile Gln Thr Val Val Lys Lys Lys Leu Ser Glu Ile Gln Leu Asp Lys 
        835                 840                 845             


Thr Gly His Phe Pro Met Tyr Gly Lys Glu Ser Asp Pro Arg Thr Tyr 
    850                 855                 860                 


Glu Ala Ile Arg Gln Arg Leu Leu Glu His Asn Asn Asp Pro Lys Lys 
865                 870                 875                 880 


Ala Phe Gln Glu Pro Leu Tyr Lys Pro Lys Lys Asn Gly Glu Leu Gly 
                885                 890                 895     


Pro Ile Ile Arg Thr Ile Lys Ile Ile Asp Thr Thr Asn Gln Val Ile 
            900                 905                 910         


Pro Leu Asn Asp Gly Lys Thr Val Ala Tyr Asn Ser Asn Ile Val Arg 
        915                 920                 925             


Val Asp Val Phe Glu Lys Asp Gly Lys Tyr Tyr Cys Val Pro Ile Tyr 
    930                 935                 940                 


Thr Ile Asp Met Met Lys Gly Ile Leu Pro Asn Lys Ala Ile Glu Pro 
945                 950                 955                 960 


Asn Lys Pro Tyr Ser Glu Trp Lys Glu Met Thr Glu Asp Tyr Thr Phe 
                965                 970                 975     


Arg Phe Ser Leu Tyr Pro Asn Asp Leu Ile Arg Ile Glu Phe Pro Arg 
            980                 985                 990         


Glu Lys Thr Ile Lys Thr Ala Val  Gly Glu Glu Ile Lys  Ile Lys Asp 
        995                 1000                 1005             


Leu Phe  Ala Tyr Tyr Gln Thr  Ile Asp Ser Ser Asn  Gly Gly Leu 
    1010                 1015                 1020             


Ser Leu  Val Ser His Asp Asn  Asn Phe Ser Leu Arg  Ser Ile Gly 
    1025                 1030                 1035             


Ser Arg  Thr Leu Lys Arg Phe  Glu Lys Tyr Gln Val  Asp Val Leu 
    1040                 1045                 1050             


Gly Asn  Ile Tyr Lys Val Arg  Gly Glu Lys Arg Val  Gly Val Ala 
    1055                 1060                 1065             


Ser Ser  Ser His Ser Lys Ala  Gly Glu Thr Ile Arg  Pro Leu 
    1070                 1075                 1080         


<210>  2
<211>  8
<212>  PRT
<213>  Geobacillus thermodenitrificans T12

<400>  2

Glu Lys Asp Gly Lys Tyr Tyr Cys 
1               5               


<210>  3
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid motif from Cas9


<220>
<221>  X
<222>  (1)..(1)
<223>  Isoleucine, Methionine or Proline

<220>
<221>  X
<222>  (2)..(2)
<223>  Valine, Serine, Asparagine or Isoleucine

<220>
<221>  X
<222>  (5)..(5)
<223>  Glutamate or Lysine

<220>
<221>  X
<222>  (6)..(6)
<223>  Alanine, Glutamate or Arginine

<400>  3

Xaa Xaa Cys Thr Xaa Xaa 
1               5       


<210>  4
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid motif from G. thermodenitrificans T12 Cas9


<220>
<221>  X
<222>  (1)..(1)
<223>  Methionine or Phenylalanine

<220>
<221>  X
<222>  (4)..(4)
<223>  Histidine or Asparagine

<400>  4

Xaa Leu Lys Xaa Ile Glu 
1               5       


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid motif from G. thermodenitrificans T12


<220>
<221>  X
<222>  (1)..(1)
<223>  Glutamate or Isoleucine

<220>
<221>  X
<222>  (5)..(5)
<223>  Tryptophan, Serine or Lysine

<400>  5

Xaa Val Tyr Ser Xaa Lys 
1               5       


<210>  6
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  amino acid motif from thermophilic Cas9


<220>
<221>  X
<222>  (1)..(1)
<223>  Alanine or Glutamate

<220>
<221>  X
<222>  (4)..(4)
<223>  Glutamine or Lysine

<220>
<221>  X
<222>  (5)..(5)
<223>  Arginine or Alanine

<220>
<221>  X
<222>  (9)..(9)
<223>  Asparagine or Alanine

<220>
<221>  X
<222>  (12)..(12)
<223>  Lysine or Serine

<400>  6

Xaa Phe Tyr Xaa Xaa Arg Glu Gln Xaa Lys Glu Xaa 
1               5                   10          


<210>  7
<211>  3249
<212>  DNA
<213>  Geobacillus thermodenitrificans T12

<400>  7
atgaagtata aaatcggtct tgatatcggc attacgtcta tcggttgggc tgtcattaat       60

ttggacattc ctcgcatcga agatttaggt gtccgcattt ttgacagagc ggaaaacccg      120

aaaaccgggg agtcactagc tcttccacgt cgcctcgccc gctccgcccg acgtcgtctg      180

cggcgtcgca aacatcgact ggagcgcatt cgccgcctgt tcgtccgcga aggaatttta      240

acgaaggaag agctgaacaa gctgtttgaa aaaaagcacg aaatcgacgt ctggcagctt      300

cgtgttgaag cactggatcg aaaactaaat aacgatgaat tagcccgcat ccttcttcat      360

ctggctaaac ggcgtggatt tagatccaac cgcaagagtg agcgcaccaa caaagaaaac      420

agtacgatgc tcaaacatat tgaagaaaac caatccattc tttcaagtta ccgaacggtt      480

gcagaaatgg ttgtcaagga tccgaaattt tccctgcaca agcgtaataa agaggataat      540

tacaccaaca ctgttgcccg cgacgatctt gaacgggaaa tcaaactgat tttcgccaaa      600

cagcgcgaat atgggaacat cgtttgcaca gaagcatttg aacacgagta tatttccatt      660

tgggcatcgc aacgcccttt tgcttctaag gatgatatcg agaaaaaagt cggtttctgt      720

acgtttgagc ctaaagaaaa acgcgcgcca aaagcaacat acacattcca gtccttcacc      780

gtctgggaac atattaacaa acttcgtctt gtctccccgg gaggcatccg ggcactaacc      840

gatgatgaac gtcgtcttat atacaagcaa gcatttcata aaaataaaat caccttccat      900

gatgttcgaa cattgcttaa cttgcctgac gacacccgtt ttaaaggtct tttatatgac      960

cgaaacacca cgctgaagga aaatgagaaa gttcgcttcc ttgaactcgg cgcctatcat     1020

aaaatacgga aagcgatcga cagcgtctat ggcaaaggag cagcaaaatc atttcgtccg     1080

attgattttg atacatttgg ctacgcatta acgatgttta aagacgacac cgacattcgc     1140

agttacttgc gaaacgaata cgaacaaaat ggaaaacgaa tggaaaatct agcggataaa     1200

gtctatgatg aagaattgat tgaagaactt ttaaacttat cgttttctaa gtttggtcat     1260

ctatccctta aagcgcttcg caacatcctt ccatatatgg aacaaggcga agtctactca     1320

accgcttgtg aacgagcagg atatacattt acagggccaa agaaaaaaca gaaaacggta     1380

ttgctgccga acattccgcc gatcgccaat ccggtcgtca tgcgcgcact gacacaggca     1440

cgcaaagtgg tcaatgccat tatcaaaaag tacggctcac cggtctccat ccatatcgaa     1500

ctggcccggg aactatcaca atcctttgat gaacgacgta aaatgcagaa agaacaggaa     1560

ggaaaccgaa agaaaaacga aactgccatt cgccaacttg ttgaatatgg gctgacgctc     1620

aatccaactg ggcttgacat tgtgaaattc aaactatgga gcgaacaaaa cggaaaatgt     1680

gcctattcac tccaaccgat cgaaatcgag cggttgctcg aaccaggcta tacagaagtc     1740

gaccatgtga ttccatacag ccgaagcttg gacgatagct ataccaataa agttcttgtg     1800

ttgacaaagg agaaccgtga aaaaggaaac cgcaccccag ctgaatattt aggattaggc     1860

tcagaacgtt ggcaacagtt cgagacgttt gtcttgacaa ataagcagtt ttcgaaaaag     1920

aagcgggatc gactccttcg gcttcattac gatgaaaacg aagaaaatga gtttaaaaat     1980

cgtaatctaa atgatacccg ttatatctca cgcttcttgg ctaactttat tcgcgaacat     2040

ctcaaattcg ccgacagcga tgacaaacaa aaagtataca cggtcaacgg ccgtattacc     2100

gcccatttac gcagccgttg gaattttaac aaaaaccggg aagaatcgaa tttgcatcat     2160

gccgtcgatg ctgccatcgt cgcctgcaca acgccgagcg atatcgcccg agtcaccgcc     2220

ttctatcaac ggcgcgaaca aaacaaagaa ctgtccaaaa agacggatcc gcagtttccg     2280

cagccttggc cgcactttgc tgatgaactg caggcgcgtt tatcaaaaaa tccaaaggag     2340

agtataaaag ctctcaatct tggaaattat gataacgaga aactcgaatc gttgcagccg     2400

gtttttgtct cccgaatgcc gaagcggagc ataacaggag cggctcatca agaaacattg     2460

cggcgttata tcggcatcga cgaacggagc ggaaaaatac agacggtcgt caaaaagaaa     2520

ctatccgaga tccaactgga taaaacaggt catttcccaa tgtacgggaa agaaagcgat     2580

ccaaggacat atgaagccat tcgccaacgg ttgcttgaac ataacaatga cccaaaaaag     2640

gcgtttcaag agcctctgta taaaccgaag aagaacggag aactaggtcc tatcatccga     2700

acaatcaaaa tcatcgatac gacaaatcaa gttattccgc tcaacgatgg caaaacagtc     2760

gcctacaaca gcaacatcgt gcgggtcgac gtctttgaga aagatggcaa atattattgt     2820

gtccctatct atacaataga tatgatgaaa gggatcttgc caaacaaggc gatcgagccg     2880

aacaaaccgt actctgagtg gaaggaaatg acggaggact atacattccg attcagtcta     2940

tacccaaatg atcttatccg tatcgaattt ccccgagaaa aaacaataaa gactgctgtg     3000

ggggaagaaa tcaaaattaa ggatctgttc gcctattatc aaaccatcga ctcctccaat     3060

ggagggttaa gtttggttag ccatgataac aacttttcgc tccgcagcat cggttcaaga     3120

accctcaaac gattcgagaa ataccaagta gatgtgctag gcaacatcta caaagtgaga     3180

ggggaaaaga gagttggggt ggcgtcatct tctcattcga aagccgggga aactatccgt     3240

ccgttataa                                                             3249


<210>  8
<211>  1045
<212>  PRT
<213>  Actinomyces naeslundii

<400>  8

Met Trp Tyr Ala Ser Leu Met Ser Ala His His Leu Arg Val Gly Ile 
1               5                   10                  15      


Asp Val Gly Thr His Ser Val Gly Leu Ala Thr Leu Arg Val Asp Asp 
            20                  25                  30          


His Gly Thr Pro Ile Glu Leu Leu Ser Ala Leu Ser His Ile His Asp 
        35                  40                  45              


Ser Gly Val Gly Lys Glu Gly Lys Lys Asp His Asp Thr Arg Lys Lys 
    50                  55                  60                  


Leu Ser Gly Ile Ala Arg Arg Ala Arg Arg Leu Leu His His Arg Arg 
65                  70                  75                  80  


Thr Gln Leu Gln Gln Leu Asp Glu Val Leu Arg Asp Leu Gly Phe Pro 
                85                  90                  95      


Ile Pro Thr Pro Gly Glu Phe Leu Asp Leu Asn Glu Gln Thr Asp Pro 
            100                 105                 110         


Tyr Arg Val Trp Arg Val Arg Ala Arg Leu Val Glu Glu Lys Leu Pro 
        115                 120                 125             


Glu Glu Leu Arg Gly Pro Ala Ile Ser Met Ala Val Arg His Ile Ala 
    130                 135                 140                 


Arg His Arg Gly Trp Arg Asn Pro Tyr Ser Lys Val Glu Ser Leu Leu 
145                 150                 155                 160 


Ser Pro Ala Asn Ala Asn Glu Ile Arg Lys Ile Cys Ala Arg Gln Gly 
                165                 170                 175     


Val Ser Pro Asp Val Cys Lys Gln Leu Leu Arg Ala Val Phe Lys Ala 
            180                 185                 190         


Asp Ser Pro Arg Gly Ser Ala Val Ser Arg Val Ala Pro Asp Pro Leu 
        195                 200                 205             


Pro Gly Gln Gly Ser Phe Arg Arg Ala Pro Lys Cys Asp Pro Glu Phe 
    210                 215                 220                 


Gln Arg Phe Arg Ile Ile Ser Ile Val Ala Asn Leu Arg Ile Ser Glu 
225                 230                 235                 240 


Thr Lys Gly Glu Asn Arg Pro Leu Thr Ala Asp Glu Arg Arg His Val 
                245                 250                 255     


Val Thr Phe Leu Thr Glu Asp Ser Gln Ala Asp Leu Thr Trp Val Asp 
            260                 265                 270         


Val Ala Glu Lys Leu Gly Val His Arg Arg Asp Leu Arg Gly Thr Ala 
        275                 280                 285             


Val His Thr Asp Asp Gly Glu Arg Ser Ala Ala Arg Pro Pro Ile Asp 
    290                 295                 300                 


Ala Thr Asp Arg Ile Met Arg Gln Thr Lys Ile Ser Ser Leu Lys Thr 
305                 310                 315                 320 


Trp Trp Glu Glu Ala Asp Ser Glu Gln Arg Gly Ala Met Ile Arg Tyr 
                325                 330                 335     


Leu Tyr Glu Asp Pro Thr Asp Ser Glu Cys Ala Glu Ile Ile Ala Glu 
            340                 345                 350         


Leu Pro Glu Glu Asp Gln Ala Lys Leu Asp Ser Leu His Leu Pro Ala 
        355                 360                 365             


Gly Arg Ala Ala Tyr Ser Arg Glu Ser Leu Thr Ala Leu Ser Asp His 
    370                 375                 380                 


Met Leu Ala Thr Thr Asp Asp Leu His Glu Ala Arg Lys Arg Leu Phe 
385                 390                 395                 400 


Gly Val Asp Asp Ser Trp Ala Pro Pro Ala Glu Ala Ile Asn Ala Pro 
                405                 410                 415     


Val Gly Asn Pro Ser Val Asp Arg Thr Leu Lys Ile Val Gly Arg Tyr 
            420                 425                 430         


Leu Ser Ala Val Glu Ser Met Trp Gly Thr Pro Glu Val Ile His Val 
        435                 440                 445             


Glu His Val Arg Asp Gly Phe Thr Ser Glu Arg Met Ala Asp Glu Arg 
    450                 455                 460                 


Asp Lys Ala Asn Arg Arg Arg Tyr Asn Asp Asn Gln Glu Ala Met Lys 
465                 470                 475                 480 


Lys Ile Gln Arg Asp Tyr Gly Lys Glu Gly Tyr Ile Ser Arg Gly Asp 
                485                 490                 495     


Ile Val Arg Leu Asp Ala Leu Glu Leu Gln Gly Cys Ala Cys Leu Tyr 
            500                 505                 510         


Cys Gly Thr Thr Ile Gly Tyr His Thr Cys Gln Leu Asp His Ile Val 
        515                 520                 525             


Pro Gln Ala Gly Pro Gly Ser Asn Asn Arg Arg Gly Asn Leu Val Ala 
    530                 535                 540                 


Val Cys Glu Arg Cys Asn Arg Ser Lys Ser Asn Thr Pro Phe Ala Val 
545                 550                 555                 560 


Trp Ala Gln Lys Cys Gly Ile Pro His Val Gly Val Lys Glu Ala Ile 
                565                 570                 575     


Gly Arg Val Arg Gly Trp Arg Lys Gln Thr Pro Asn Thr Ser Ser Glu 
            580                 585                 590         


Asp Leu Thr Arg Leu Lys Lys Glu Val Ile Ala Arg Leu Arg Arg Thr 
        595                 600                 605             


Gln Glu Asp Pro Glu Ile Asp Glu Arg Ser Met Glu Ser Val Ala Trp 
    610                 615                 620                 


Met Ala Asn Glu Leu His His Arg Ile Ala Ala Ala Tyr Pro Glu Thr 
625                 630                 635                 640 


Thr Val Met Val Tyr Arg Gly Ser Ile Thr Ala Ala Ala Arg Lys Ala 
                645                 650                 655     


Ala Gly Ile Asp Ser Arg Ile Asn Leu Ile Gly Glu Lys Gly Arg Lys 
            660                 665                 670         


Asp Arg Ile Asp Arg Arg His His Ala Val Asp Ala Ser Val Val Ala 
        675                 680                 685             


Leu Met Glu Ala Ser Val Ala Lys Thr Leu Ala Glu Arg Ser Ser Leu 
    690                 695                 700                 


Arg Gly Glu Gln Arg Leu Thr Gly Lys Glu Gln Thr Trp Lys Gln Tyr 
705                 710                 715                 720 


Thr Gly Ser Thr Val Gly Ala Arg Glu His Phe Glu Met Trp Arg Gly 
                725                 730                 735     


His Met Leu His Leu Thr Glu Leu Phe Asn Glu Arg Leu Ala Glu Asp 
            740                 745                 750         


Lys Val Tyr Val Thr Gln Asn Ile Arg Leu Arg Leu Ser Asp Gly Asn 
        755                 760                 765             


Ala His Thr Val Asn Pro Ser Lys Leu Val Ser His Arg Leu Gly Asp 
    770                 775                 780                 


Gly Leu Thr Val Gln Gln Ile Asp Arg Ala Cys Thr Pro Ala Leu Trp 
785                 790                 795                 800 


Cys Ala Leu Thr Arg Glu Lys Asp Phe Asp Glu Lys Asn Gly Leu Pro 
                805                 810                 815     


Ala Arg Glu Asp Arg Ala Ile Arg Val His Gly His Glu Ile Lys Ser 
            820                 825                 830         


Ser Asp Tyr Ile Gln Val Phe Ser Lys Arg Lys Lys Thr Asp Ser Asp 
        835                 840                 845             


Arg Asp Glu Thr Pro Phe Gly Ala Ile Ala Val Arg Gly Gly Phe Val 
    850                 855                 860                 


Glu Ile Gly Pro Ser Ile His His Ala Arg Ile Tyr Arg Val Glu Gly 
865                 870                 875                 880 


Lys Lys Pro Val Tyr Ala Met Leu Arg Val Phe Thr His Asp Leu Leu 
                885                 890                 895     


Ser Gln Arg His Gly Asp Leu Phe Ser Ala Val Ile Pro Pro Gln Ser 
            900                 905                 910         


Ile Ser Met Arg Cys Ala Glu Pro Lys Leu Arg Lys Ala Ile Thr Thr 
        915                 920                 925             


Gly Asn Ala Thr Tyr Leu Gly Trp Val Val Val Gly Asp Glu Leu Glu 
    930                 935                 940                 


Ile Asn Val Asp Ser Phe Thr Lys Tyr Ala Ile Gly Arg Phe Leu Glu 
945                 950                 955                 960 


Asp Phe Pro Asn Thr Thr Arg Trp Arg Ile Cys Gly Tyr Asp Thr Asn 
                965                 970                 975     


Ser Lys Leu Thr Leu Lys Pro Ile Val Leu Ala Ala Glu Gly Leu Glu 
            980                 985                 990         


Asn Pro Ser Ser Ala Val Asn Glu  Ile Val Glu Leu Lys  Gly Trp Arg 
        995                 1000                 1005             


Val Ala  Ile Asn Val Leu Thr  Lys Val His Pro Thr  Val Val Arg 
    1010                 1015                 1020             


Arg Asp  Ala Leu Gly Arg Pro  Arg Tyr Ser Ser Arg  Ser Asn Leu 
    1025                 1030                 1035             


Pro Thr  Ser Trp Thr Ile Glu  
    1040                 1045 


<210>  9
<211>  1160
<212>  PRT
<213>  Streptococcus pyogenes

<400>  9

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Arg 
            180                 185                 190         


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
        195                 200                 205             


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
    210                 215                 220                 


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
225                 230                 235                 240 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
                245                 250                 255     


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
            260                 265                 270         


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
        275                 280                 285             


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
    290                 295                 300                 


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
305                 310                 315                 320 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
                325                 330                 335     


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
            340                 345                 350         


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
        355                 360                 365             


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
    370                 375                 380                 


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
385                 390                 395                 400 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
                405                 410                 415     


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
            420                 425                 430         


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
        435                 440                 445             


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
    450                 455                 460                 


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
465                 470                 475                 480 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
                485                 490                 495     


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
            500                 505                 510         


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
        515                 520                 525             


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
    530                 535                 540                 


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
545                 550                 555                 560 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
                565                 570                 575     


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
            580                 585                 590         


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
        595                 600                 605             


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
    610                 615                 620                 


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
625                 630                 635                 640 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
                645                 650                 655     


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
            660                 665                 670         


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
        675                 680                 685             


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
    690                 695                 700                 


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
705                 710                 715                 720 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
                725                 730                 735     


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
            740                 745                 750         


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
        755                 760                 765             


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
    770                 775                 780                 


Val Gly Thr Ala Leu Ile Lys Lys Tyr Pro Lys Leu Glu Ser Glu Phe 
785                 790                 795                 800 


Val Tyr Gly Asp Tyr Lys Val Tyr Asp Val Arg Lys Met Ile Ala Lys 
                805                 810                 815     


Ser Glu Gln Glu Ile Gly Lys Ala Thr Ala Lys Tyr Phe Phe Tyr Ser 
            820                 825                 830         


Asn Ile Met Asn Phe Phe Lys Thr Glu Ile Thr Leu Ala Asn Gly Glu 
        835                 840                 845             


Ile Arg Lys Arg Pro Leu Ile Glu Thr Asn Gly Glu Thr Gly Glu Ile 
    850                 855                 860                 


Val Trp Asp Lys Gly Arg Asp Phe Ala Thr Val Arg Lys Val Leu Ser 
865                 870                 875                 880 


Met Pro Gln Val Asn Ile Val Lys Lys Thr Glu Val Gln Thr Gly Gly 
                885                 890                 895     


Phe Ser Lys Glu Ser Ile Leu Pro Lys Arg Asn Ser Asp Lys Leu Ile 
            900                 905                 910         


Ala Arg Lys Lys Asp Trp Asp Pro Lys Lys Tyr Gly Gly Phe Asp Ser 
        915                 920                 925             


Pro Thr Val Ala Tyr Ser Val Leu Val Val Ala Lys Val Glu Lys Gly 
    930                 935                 940                 


Lys Ser Lys Lys Leu Lys Ser Val Lys Glu Leu Leu Gly Ile Thr Ile 
945                 950                 955                 960 


Met Glu Arg Ser Ser Phe Glu Lys Asn Pro Ile Asp Phe Leu Glu Ala 
                965                 970                 975     


Lys Gly Tyr Lys Glu Val Lys Lys Asp Leu Ile Ile Lys Leu Pro Lys 
            980                 985                 990         


Tyr Ser Leu Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
        995                 1000                 1005             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1010                 1015                 1020             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1025                 1030                 1035             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1040                 1045                 1050             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1055                 1060                 1065             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1070                 1075                 1080             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1085                 1090                 1095             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1100                 1105                 1110             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1115                 1120                 1125             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1130                 1135                 1140             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1145                 1150                 1155             


Gly Asp  
    1160 


<210>  10
<211>  8
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PAM


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, or t

<400>  10
ccccccna                                                                 8


<210>  11
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM

<400>  11
ccccccaa                                                                 8


<210>  12
<211>  5
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM

<400>  12
ccccc                                                                    5


<210>  13
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM


<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  n is a, c, g, or t

<400>  13
cccccnna                                                                 8


<210>  14
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM

<400>  14
cccccc                                                                   6


<210>  15
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<400>  15
nccccc                                                                   6


<210>  16
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is a, c, g, or t

<400>  16
ncccccna                                                                 8


<210>  17
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  n is a, c, g, or t

<400>  17
cnccccac                                                                 8


<210>  18
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM

<400>  18
ccccccag                                                                 8


<210>  19
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM

<400>  19
ccccccat                                                                 8


<210>  20
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM

<400>  20
ccccccac                                                                 8


<210>  21
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM

<400>  21
atccccaa                                                                 8


<210>  22
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM

<400>  22
acggccaa                                                                 8


<210>  23
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-1 domain motif

<400>  23

Ile Gly Leu Asp Ile Gly Ile Thr Ser Ile Gly 
1               5                   10      


<210>  24
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-I domain motif

<400>  24

Ile Gly Leu Asp Ile Gly Ile Thr Ser Ile Gly Trp Ala Val Ile Asn 
1               5                   10                  15      


Leu Asp 
        


<210>  25
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bridge domain motif

<400>  25

Arg Ser Ala Arg Arg 
1               5   


<210>  26
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bridge domain motif

<400>  26

Pro Arg Arg Leu Ala Arg Ser Ala Arg Arg Arg Leu Arg Arg Arg Lys 
1               5                   10                  15      


His Arg Leu Glu Arg Ile Arg Arg Leu 
            20                  25  


<210>  27
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helical/recognition lobe domain motif

<400>  27

Trp Gln Leu Arg 
1               


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helical/recognition lobe domain

<400>  28

His Leu Ala Lys Arg Arg Gly 
1               5           


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helical/recognition lobe domain

<400>  29

Leu Ala Arg Ile Leu Leu His Leu Ala Lys Arg Arg Gly 
1               5                   10              


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helical/recognition lobe domain

<400>  30

Ile Phe Ala Lys Gln 
1               5   


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helical/recognition lobe domain

<400>  31

Glu Ile Lys Leu Ile Phe Ala Lys Gln 
1               5                   


<210>  32
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helical/recognition lobe domain

<400>  32

Ile Trp Ala Ser Gln Arg 
1               5       


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helical/recognition lobe domain motif

<400>  33

Lys Val Gly Phe Cys Thr Phe Glu Pro Lys Glu Lys Arg Ala Pro Lys 
1               5                   10                  15      


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha-helical/recognition lobe domain motif

<400>  34

Phe Thr Val Trp Glu His Ile Asn Lys Leu Arg Leu 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-II domain motif

<400>  35

Ile Ala Asn Pro Val Val Met Arg Ala Leu Thr Gln 
1               5                   10          


<210>  36
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-II domain motif

<400>  36

Ile Ala Asn Pro Val Val Met Arg Ala Leu Thr Gln Ala Arg Lys Val 
1               5                   10                  15      


Val Asn Ala Ile Ile Lys Lys Tyr Gly 
            20                  25  


<210>  37
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-II domain motif

<400>  37

Glu Leu Ala Arg 
1               


<210>  38
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-II domain motif

<400>  38

Ile His Ile Glu Leu Ala Arg Glu 
1               5               


<210>  39
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNH domain motif

<400>  39

Gln Asn Gly Lys Cys Ala Tyr 
1               5           


<210>  40
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNH domain motif

<400>  40

Ile Val Lys Phe Lys Leu Trp Ser Glu Gln Asn Gly Lys Cys Ala Tyr 
1               5                   10                  15      


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNH domain motif

<400>  41

Val Asp His Val Ile Pro 
1               5       


<210>  42
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNH domain motif

<400>  42

Val Asp His Val Ile Pro Tyr Ser Arg Ser Leu Asp Asp Ser Tyr Thr 
1               5                   10                  15      


Asn Lys Val Leu 
            20  


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-III domain  motif

<400>  43

Asp Thr Arg Tyr Ile Ser Arg Phe Leu Ala Asn 
1               5                   10      


<210>  44
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-III domain motif

<400>  44

Val Tyr Thr Val Asn Gly Arg Ile Thr Ala His Leu Arg Ser Arg Trp 
1               5                   10                  15      


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-III domain motif

<400>  45

His His Ala Val Asp Ala 
1               5       


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RuvC-III domain motif

<400>  46

His His Ala Val Asp Ala Ala Ile Val Ala 
1               5                   10  


<210>  47
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  n is a, c, g, or t

<400>  47
nnnncnna                                                                 8


<210>  48
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<400>  48
nnnncvaa                                                                 8


<210>  49
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<400>  49
nnnncsaa                                                                 8


<210>  50
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<400>  50
nnnncgaa                                                                 8


<210>  51
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<400>  51
nnnnccaa                                                                 8


<210>  52
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  n is a, c, g, or t

<400>  52
nnnncnaa                                                                 8


<210>  53
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAM


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<400>  53
nnnncmca                                                                 8


<210>  54
<211>  30
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA 5' hairpin

<400>  54
aagggcuuuc ugccuauagg cagacugccc                                        30


<210>  55
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA 'middle' hairpin

<400>  55
guggcguugg ggaucgccua ucgcc                                             25


<210>  56
<211>  36
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA 3' hairpin

<400>  56
cgcuuucuuc gggcauuccc cacucuuagg cguuuu                                 36


<210>  57
<211>  55
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA 5' hairpin and middle hairpin

<400>  57
aagggcuuuc ugccuauagg cagacugccc guggcguugg ggaucgccua ucgcc            55


<210>  58
<211>  91
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  tracrRNA  5' hairpin, middle hairpin and 3' hairpin.

<400>  58
aagggcuuuc ugccuauagg cagacugccc guggcguugg ggaucgccua ucgcccgcuu       60

ucuucgggca uuccccacuc uuaggcguuu u                                      91


<210>  59
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG6494


<220>
<221>  misc_feature
<222>  (35)..(41)
<223>  n is a, c, g, or t

<400>  59
tatgcctcat gagattatca aaaaggatct tcacnnnnnn nctagatcct tttaaattaa       60

aaatgaagtt ttaaatcaat c                                                 81


<210>  60
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG6495

<400>  60
tatgccggat cctcagacca agtttactca tatatacttt agattgattt aaaacttcat       60

ttttaattta aaaggatcta g                                                 81


<210>  61
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG7356

<400>  61
tcgtcggcag cgtcagatgt gtataagaga cagt                                   34


<210>  62
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG7357

<400>  62
ctgtctctta tacacatctg acgctgccga cga                                    33


<210>  63
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG7358

<400>  63
tcgtcggcag cgtcag                                                       16


<210>  64
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG7359

<400>  64
gtctcgtggg ctcggagatg tgtataagag acaggaccat gattacgcca agc              53


<210>  65
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG7616

<400>  65
tcgtcggcag cgtcagatgt gtataagaga cagggtcatg agattatcaa aaaggatctt       60

c                                                                       61


<210>  66
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8157

<400>  66
tatgcctcat gagattatca aaaaggatct tcaccccccc agctagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  67
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8158

<400>  67
tatgcctcat gagattatca aaaaggatct tcaccccccc aactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  68
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8159

<400>  68
tatgcctcat gagattatca aaaaggatct tcaccccccc atctagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  69
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8160

<400>  69
tatgcctcat gagattatca aaaaggatct tcaccccccc acctagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  70
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8161


<220>
<221>  misc_feature
<222>  (35)..(38)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (40)..(41)
<223>  n is a, c, g, or t

<400>  70
tatgcctcat gagattatca aaaaggatct tcacnnnntn nctagatcct tttaaattaa       60

aaatgaagtt ttaaatcaat c                                                 81


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8363

<400>  71
acggttatcc acagaatcag                                                   20


<210>  72
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8364

<400>  72
cgggattgac ttttaaaaaa gg                                                22


<210>  73
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8763

<400>  73
tatgcctcat gagattatca aaaaggatct tcacccccca aactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  74
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8764

<400>  74
tatgcctcat gagattatca aaaaggatct tcacccccca tactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  75
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8765

<400>  75
tatgcctcat gagattatca aaaaggatct tcacccccca gactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  76
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8766

<400>  76
tatgcctcat gagattatca aaaaggatct tcacccccca cactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  77
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8767

<400>  77
tatgcctcat gagattatca aaaaggatct tcacccccct aactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  78
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8768

<400>  78
tatgcctcat gagattatca aaaaggatct tcacccccct tactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  79
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8769

<400>  79
tatgcctcat gagattatca aaaaggatct tcacccccct gactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  80
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8770

<400>  80
tatgcctcat gagattatca aaaaggatct tcacccccct cactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  81
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8771

<400>  81
tatgcctcat gagattatca aaaaggatct tcaccccccg aactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  82
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8772

<400>  82
tatgcctcat gagattatca aaaaggatct tcaccccccg tactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  83
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8773

<400>  83
tatgcctcat gagattatca aaaaggatct tcaccccccg gactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  84
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8774

<400>  84
tatgcctcat gagattatca aaaaggatct tcaccccccg cactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  85
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8775

<400>  85
tatgcctcat gagattatca aaaaggatct tcaccccccc aactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  86
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8776

<400>  86
tatgcctcat gagattatca aaaaggatct tcaccccccc tactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  87
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8777

<400>  87
tatgcctcat gagattatca aaaaggatct tcaccccccc gactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  88
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8778

<400>  88
tatgcctcat gagattatca aaaaggatct tcaccccccc cactagatcc ttttaaatta       60

aaaatgaagt tttaaatcaa tc                                                82


<210>  89
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG6574

<400>  89
aagcttgaaa taatacgact cactatagg                                         29


<210>  90
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG6576

<400>  90
aaaaaagacc ttgacgtttt cc                                                22


<210>  91
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9307

<400>  91
aagcttgaaa taatacgact cactataggt gagattatca aaaaggatct tcacgtc          57


<210>  92
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9309

<400>  92
aaaacgccta agagtgggga atg                                               23


<210>  93
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9310

<400>  93
aaaaggcgat aggcgatcc                                                    19


<210>  94
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9311

<400>  94
aaaacgggtc agtctgccta tag                                               23


<210>  95
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9308

<400>  95
aagcttgaaa taatacgact cactataggt gagattatca aaaaggatct tcacgtc          57


<210>  96
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG10118

<400>  96
aagcttgaaa taatacgact cactatagga gattatcaaa aaggatcttc acgtca           56


<210>  97
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG10119

<400>  97
aagcttgaaa taatacgact cactatagga agattatcaa aaaggatctt cacgtcatag       60


<210>  98
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG10120

<400>  98
aagcttgaaa taatacgact cactatagga ttatcaaaaa ggatcttcac gtcatagt         58


<210>  99
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG10121

<400>  99
aagcttgaaa taatacgact cactatagga attatcaaaa aggatcttca cgtcatagtt       60


<210>  100
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG10122

<400>  100
aagcttgaaa taatacgact cactataggt tatcaaaaag gatcttcacg tcatagtt         58


<210>  101
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG10123

<400>  101
aagcttgaaa taatacgact cactataggt atcaaaaagg atcttcacgt catagttc         58


<210>  102
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG10124

<400>  102
aagcttgaaa taatacgact cactatagga tcaaaaagga tcttcacgtc atagttc          57


<210>  103
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9312

<400>  103
aaaacgccta agagtgggga atgcccgaag aaagcgggcg ataggcgatc c                51


<210>  104
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8191

<400>  104
aagcttggcg taatcatggt c                                                 21


<210>  105
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8192

<400>  105
tcatgagttc ccatgttgtg                                                   20


<210>  106
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8194

<400>  106
tatggcgaat cacaacatgg gaactcatga gaacatcctc tttcttag                    48


<210>  107
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8195

<400>  107
gccgatatca agaccgattt tatacttcat ttaagttacc tcctcgattg                  50


<210>  108
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8196

<400>  108
atgaagtata aaatcggtct tg                                                22


<210>  109
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8197

<400>  109
taacggacgg atagtttc                                                     18


<210>  110
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8198

<400>  110
gaaagccggg gaaactatcc gtccgttata aatcagacaa aatggcctgc ttatg            55


<210>  111
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8263

<400>  111
gaactatgac actttatttt cagaatggac gtataacggt atccatttta agaataatcc       60


<210>  112
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8268

<400>  112
accgttatac gtccattctg aaaataaagt gtcatagttc ccctgagat                   49


<210>  113
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8210

<400>  113
aacagctatg accatgatta cgccaagctt ccctcccatg cacaatag                    48


<210>  114
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8261

<400>  114
gaactatgac atcatggagt tttaaatcca gtataacggt atccatttta agaataatcc       60


<210>  115
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8266

<400>  115
accgttatac tggatttaaa actccatgat gtcatagttc ccctgagat                   49


<210>  116
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8317

<400>  116
gaactatgac cacccagctt acatcaacaa gtataacggt atccatttta agaataatcc       60


<210>  117
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8320

<400>  117
accgttatac ttgttgatgt aagctgggtg gtcatagttc ccctgagat                   49


<210>  118
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9075

<400>  118
ctatcggcat tacgtctatc                                                   20


<210>  119
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9091

<400>  119
gcgtcgactt ctgtatagc                                                    19


<210>  120
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9091

<400>  120
tgaagtataa aatcggtctt gctatcggca ttacgtctat c                           41


<210>  121
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9092

<400>  121
caagcttcgg ctgtatggaa tcacagcgtc gacttctgta tagc                        44


<210>  122
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9077

<400>  122
gctgtgattc catacag                                                      17


<210>  123
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9267

<400>  123
ggtgcagtag gttgcagcta tgcttgtata acggtatcca t                           41


<210>  124
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9263

<400>  124
aagcatagct gcaacctact gcaccgtcat agttcccctg agattatcg                   49


<210>  125
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9088

<400>  125
tcatgaccaa aatcccttaa cg                                                22


<210>  126
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9089

<400>  126
ttaagggatt ttggtcatga gaacatcctc tttcttag                               38


<210>  127
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9090

<400>  127
gcaagaccga ttttatactt catttaag                                          28


<210>  128
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9548

<400>  128
ggatcccatg acgctagtat ccagctgggt catagttccc ctgagattat cg               52


<210>  129
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9601

<400>  129
ttcaatattt tttttgaata aaaaatacga tacaataaaa atgtctagaa aaagataaaa       60

atg                                                                     63


<210>  130
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9600

<400>  130
ttttttattc aaaaaaaata ttgaatttta aaaatgatgg tgctagtatg aag              53


<210>  131
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9549

<400>  131
ccagctggat actagcgtca tgggatccgt ataacggtat ccattttaag aataatcc         58


<210>  132
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8552

<400>  132
tcgggggttc gtttcccttg                                                   20


<210>  133
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8553

<400>  133
cttacacagc cagtgacgga ac                                                22


<210>  134
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2365

<400>  134
gccggcgtcc cggaaaacga                                                   20


<210>  135
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2366

<400>  135
gcaggtcggg ttcctcgcat ccatgccccc gaact                                  35


<210>  136
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2367

<400>  136
ggcttcggaa tcgttttccg ggacgccggc acggcattgg caaggccaag                  50


<210>  137
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2368

<400>  137
gacacaggca tcggtgcagg gtctcttggc aagtc                                  35


<210>  138
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2369

<400>  138
gccaagagac cctgcaccga tgcctgtgtc gaacc                                  35


<210>  139
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2370

<400>  139
cttggcggaa aacgtcaagg tcttttttac acgcgcatca acttcaaggc                  50


<210>  140
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2371

<400>  140
atgacgagct gttcaccagc agcgctatta ttgaagcatt tatcaggg                    48


<210>  141
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2372

<400>  141
gtaaaaaaga ccttgacgtt ttc                                               23


<210>  142
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2373

<400>  142
tatgaagcgg gccatttgaa gacgaaaggg cctc                                   34


<210>  143
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2374

<400>  143
taatagcgct gctggtgaac agctcgtcat agttcccctg agattatcg                   49


<210>  144
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2375

<400>  144
tggagtcatg aacatatgaa gtataaaatc ggtcttg                                37


<210>  145
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2376

<400>  145
ccctttcgtc ttcaaatggc ccgcttcata agcag                                  35


<210>  146
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2377

<400>  146
gattttatac ttcatatgtt catgactcca ttattattg                              39


<210>  147
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2378

<400>  147
gggggcatgg atgcgaggaa cccgacctgc attgg                                  35


<210>  148
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2381

<400>  148
acacggcgga tgcacttacc                                                   20


<210>  149
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2382

<400>  149
tggacgtgta cttcgacaac                                                   20


<210>  150
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG2135

<400>  150
acacggcgga tgcacttacc                                                   20


<210>  151
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8196

<400>  151
tggacgtgta cttcgacaac                                                   20


<210>  152
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8197

<400>  152
taacggacgg atagtttc                                                     18


<210>  153
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG6850

<400>  153
gcctcatgaa tgcagcgatg gtccggtgtt c                                      31


<210>  154
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG6849

<400>  154
gcctcatgag ttcccatgtt gtgattc                                           27


<210>  155
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG6769

<400>  155
caatccaact gggcttgac                                                    19


<210>  156
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG6841

<400>  156
caagaacttt attggtatag                                                   20


<210>  157
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG6840

<400>  157
ttgcagaaat ggttgtcaag                                                   20


<210>  158
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9215

<400>  158
gagataatgc cgactgtac                                                    19


<210>  159
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9216

<400>  159
agggctcgcc tttgggaag                                                    19


<210>  160
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9505

<400>  160
gttgccaacg ttctgag                                                      17


<210>  161
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9506

<400>  161
aatccacgcc gtttag                                                       16


<210>  162
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8363

<400>  162
acggttatcc acagaatcag                                                   20


<210>  163
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG8364

<400>  163
cgggattgac ttttaaaaaa gg                                                22


<210>  164
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9302

<400>  164
aaacttcatt tttaatttaa aaggatctag aaccccccgt gaagatcctt tttgataatc       60

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      120


<210>  165
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9303

<400>  165
tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga       60

gattatcaaa aaggatcttc acccccccaa ctagatcctt ttaaattaaa aatgaagttt      120


<210>  166
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9304

<400>  166
tttctacggg gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga       60

gattatcaaa aaggatcttc acggggggtt ctagatcctt ttaaattaaa aatgaagttt      120


<210>  167
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG7886

<400>  167
tacttccaat ccaatgcaaa gtataaaatc ggtcttgata tcg                         43


<210>  168
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG7887

<400>  168
ttatccactt ccaatgttat tataacggac ggatagtttc cccggctttc                  50


<210>  169
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9665

<400>  169
atgacgaaag gagtttctta ttatg                                             25


<210>  170
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BG9666

<400>  170
aacggtattc cgtgattaag                                                   20


