                         SEQUENCE LISTING

<110>  HEALTH AND BIOTECH FRANCE
 
<120>  Perinatal tissue derived mesenchymal stem cells: Method of 
       preparation and uses thereof

<130>  B373499 D36728

<150>  PCT/IB/2016/001936
<151>  2016-12-12

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  739
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  isoform a of CD106 in human

<400>  1

Met Pro Gly Lys Met Val Val Ile Leu Gly Ala Ser Asn Ile Leu Trp 
1               5                   10                  15      


Ile Met Phe Ala Ala Ser Gln Ala Phe Lys Ile Glu Thr Thr Pro Glu 
            20                  25                  30          


Ser Arg Tyr Leu Ala Gln Ile Gly Asp Ser Val Ser Leu Thr Cys Ser 
        35                  40                  45              


Thr Thr Gly Cys Glu Ser Pro Phe Phe Ser Trp Arg Thr Gln Ile Asp 
    50                  55                  60                  


Ser Pro Leu Asn Gly Lys Val Thr Asn Glu Gly Thr Thr Ser Thr Leu 
65                  70                  75                  80  


Thr Met Asn Pro Val Ser Phe Gly Asn Glu His Ser Tyr Leu Cys Thr 
                85                  90                  95      


Ala Thr Cys Glu Ser Arg Lys Leu Glu Lys Gly Ile Gln Val Glu Ile 
            100                 105                 110         


Tyr Ser Phe Pro Lys Asp Pro Glu Ile His Leu Ser Gly Pro Leu Glu 
        115                 120                 125             


Ala Gly Lys Pro Ile Thr Val Lys Cys Ser Val Ala Asp Val Tyr Pro 
    130                 135                 140                 


Phe Asp Arg Leu Glu Ile Asp Leu Leu Lys Gly Asp His Leu Met Lys 
145                 150                 155                 160 


Ser Gln Glu Phe Leu Glu Asp Ala Asp Arg Lys Ser Leu Glu Thr Lys 
                165                 170                 175     


Ser Leu Glu Val Thr Phe Thr Pro Val Ile Glu Asp Ile Gly Lys Val 
            180                 185                 190         


Leu Val Cys Arg Ala Lys Leu His Ile Asp Glu Met Asp Ser Val Pro 
        195                 200                 205             


Thr Val Arg Gln Ala Val Lys Glu Leu Gln Val Tyr Ile Ser Pro Lys 
    210                 215                 220                 


Asn Thr Val Ile Ser Val Asn Pro Ser Thr Lys Leu Gln Glu Gly Gly 
225                 230                 235                 240 


Ser Val Thr Met Thr Cys Ser Ser Glu Gly Leu Pro Ala Pro Glu Ile 
                245                 250                 255     


Phe Trp Ser Lys Lys Leu Asp Asn Gly Asn Leu Gln His Leu Ser Gly 
            260                 265                 270         


Asn Ala Thr Leu Thr Leu Ile Ala Met Arg Met Glu Asp Ser Gly Ile 
        275                 280                 285             


Tyr Val Cys Glu Gly Val Asn Leu Ile Gly Lys Asn Arg Lys Glu Val 
    290                 295                 300                 


Glu Leu Ile Val Gln Glu Lys Pro Phe Thr Val Glu Ile Ser Pro Gly 
305                 310                 315                 320 


Pro Arg Ile Ala Ala Gln Ile Gly Asp Ser Val Met Leu Thr Cys Ser 
                325                 330                 335     


Val Met Gly Cys Glu Ser Pro Ser Phe Ser Trp Arg Thr Gln Ile Asp 
            340                 345                 350         


Ser Pro Leu Ser Gly Lys Val Arg Ser Glu Gly Thr Asn Ser Thr Leu 
        355                 360                 365             


Thr Leu Ser Pro Val Ser Phe Glu Asn Glu His Ser Tyr Leu Cys Thr 
    370                 375                 380                 


Val Thr Cys Gly His Lys Lys Leu Glu Lys Gly Ile Gln Val Glu Leu 
385                 390                 395                 400 


Tyr Ser Phe Pro Arg Asp Pro Glu Ile Glu Met Ser Gly Gly Leu Val 
                405                 410                 415     


Asn Gly Ser Ser Val Thr Val Ser Cys Lys Val Pro Ser Val Tyr Pro 
            420                 425                 430         


Leu Asp Arg Leu Glu Ile Glu Leu Leu Lys Gly Glu Thr Ile Leu Glu 
        435                 440                 445             


Asn Ile Glu Phe Leu Glu Asp Thr Asp Met Lys Ser Leu Glu Asn Lys 
    450                 455                 460                 


Ser Leu Glu Met Thr Phe Ile Pro Thr Ile Glu Asp Thr Gly Lys Ala 
465                 470                 475                 480 


Leu Val Cys Gln Ala Lys Leu His Ile Asp Asp Met Glu Phe Glu Pro 
                485                 490                 495     


Lys Gln Arg Gln Ser Thr Gln Thr Leu Tyr Val Asn Val Ala Pro Arg 
            500                 505                 510         


Asp Thr Thr Val Leu Val Ser Pro Ser Ser Ile Leu Glu Glu Gly Ser 
        515                 520                 525             


Ser Val Asn Met Thr Cys Leu Ser Gln Gly Phe Pro Ala Pro Lys Ile 
    530                 535                 540                 


Leu Trp Ser Arg Gln Leu Pro Asn Gly Glu Leu Gln Pro Leu Ser Glu 
545                 550                 555                 560 


Asn Ala Thr Leu Thr Leu Ile Ser Thr Lys Met Glu Asp Ser Gly Val 
                565                 570                 575     


Tyr Leu Cys Glu Gly Ile Asn Gln Ala Gly Arg Ser Arg Lys Glu Val 
            580                 585                 590         


Glu Leu Ile Ile Gln Val Thr Pro Lys Asp Ile Lys Leu Thr Ala Phe 
        595                 600                 605             


Pro Ser Glu Ser Val Lys Glu Gly Asp Thr Val Ile Ile Ser Cys Thr 
    610                 615                 620                 


Cys Gly Asn Val Pro Glu Thr Trp Ile Ile Leu Lys Lys Lys Ala Glu 
625                 630                 635                 640 


Thr Gly Asp Thr Val Leu Lys Ser Ile Asp Gly Ala Tyr Thr Ile Arg 
                645                 650                 655     


Lys Ala Gln Leu Lys Asp Ala Gly Val Tyr Glu Cys Glu Ser Lys Asn 
            660                 665                 670         


Lys Val Gly Ser Gln Leu Arg Ser Leu Thr Leu Asp Val Gln Gly Arg 
        675                 680                 685             


Glu Asn Asn Lys Asp Tyr Phe Ser Pro Glu Leu Leu Val Leu Tyr Phe 
    690                 695                 700                 


Ala Ser Ser Leu Ile Ile Pro Ala Ile Gly Met Ile Ile Tyr Phe Ala 
705                 710                 715                 720 


Arg Lys Ala Asn Met Lys Gly Ser Tyr Ser Leu Val Glu Ala Gln Lys 
                725                 730                 735     


Ser Lys Val 
            


<210>  2
<211>  647
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  isoform b of CD106 human

<400>  2

Met Pro Gly Lys Met Val Val Ile Leu Gly Ala Ser Asn Ile Leu Trp 
1               5                   10                  15      


Ile Met Phe Ala Ala Ser Gln Ala Phe Lys Ile Glu Thr Thr Pro Glu 
            20                  25                  30          


Ser Arg Tyr Leu Ala Gln Ile Gly Asp Ser Val Ser Leu Thr Cys Ser 
        35                  40                  45              


Thr Thr Gly Cys Glu Ser Pro Phe Phe Ser Trp Arg Thr Gln Ile Asp 
    50                  55                  60                  


Ser Pro Leu Asn Gly Lys Val Thr Asn Glu Gly Thr Thr Ser Thr Leu 
65                  70                  75                  80  


Thr Met Asn Pro Val Ser Phe Gly Asn Glu His Ser Tyr Leu Cys Thr 
                85                  90                  95      


Ala Thr Cys Glu Ser Arg Lys Leu Glu Lys Gly Ile Gln Val Glu Ile 
            100                 105                 110         


Tyr Ser Phe Pro Lys Asp Pro Glu Ile His Leu Ser Gly Pro Leu Glu 
        115                 120                 125             


Ala Gly Lys Pro Ile Thr Val Lys Cys Ser Val Ala Asp Val Tyr Pro 
    130                 135                 140                 


Phe Asp Arg Leu Glu Ile Asp Leu Leu Lys Gly Asp His Leu Met Lys 
145                 150                 155                 160 


Ser Gln Glu Phe Leu Glu Asp Ala Asp Arg Lys Ser Leu Glu Thr Lys 
                165                 170                 175     


Ser Leu Glu Val Thr Phe Thr Pro Val Ile Glu Asp Ile Gly Lys Val 
            180                 185                 190         


Leu Val Cys Arg Ala Lys Leu His Ile Asp Glu Met Asp Ser Val Pro 
        195                 200                 205             


Thr Val Arg Gln Ala Val Lys Glu Leu Gln Val Tyr Ile Ser Pro Lys 
    210                 215                 220                 


Asn Thr Val Ile Ser Val Asn Pro Ser Thr Lys Leu Gln Glu Gly Gly 
225                 230                 235                 240 


Ser Val Thr Met Thr Cys Ser Ser Glu Gly Leu Pro Ala Pro Glu Ile 
                245                 250                 255     


Phe Trp Ser Lys Lys Leu Asp Asn Gly Asn Leu Gln His Leu Ser Gly 
            260                 265                 270         


Asn Ala Thr Leu Thr Leu Ile Ala Met Arg Met Glu Asp Ser Gly Ile 
        275                 280                 285             


Tyr Val Cys Glu Gly Val Asn Leu Ile Gly Lys Asn Arg Lys Glu Val 
    290                 295                 300                 


Glu Leu Ile Val Gln Ala Phe Pro Arg Asp Pro Glu Ile Glu Met Ser 
305                 310                 315                 320 


Gly Gly Leu Val Asn Gly Ser Ser Val Thr Val Ser Cys Lys Val Pro 
                325                 330                 335     


Ser Val Tyr Pro Leu Asp Arg Leu Glu Ile Glu Leu Leu Lys Gly Glu 
            340                 345                 350         


Thr Ile Leu Glu Asn Ile Glu Phe Leu Glu Asp Thr Asp Met Lys Ser 
        355                 360                 365             


Leu Glu Asn Lys Ser Leu Glu Met Thr Phe Ile Pro Thr Ile Glu Asp 
    370                 375                 380                 


Thr Gly Lys Ala Leu Val Cys Gln Ala Lys Leu His Ile Asp Asp Met 
385                 390                 395                 400 


Glu Phe Glu Pro Lys Gln Arg Gln Ser Thr Gln Thr Leu Tyr Val Asn 
                405                 410                 415     


Val Ala Pro Arg Asp Thr Thr Val Leu Val Ser Pro Ser Ser Ile Leu 
            420                 425                 430         


Glu Glu Gly Ser Ser Val Asn Met Thr Cys Leu Ser Gln Gly Phe Pro 
        435                 440                 445             


Ala Pro Lys Ile Leu Trp Ser Arg Gln Leu Pro Asn Gly Glu Leu Gln 
    450                 455                 460                 


Pro Leu Ser Glu Asn Ala Thr Leu Thr Leu Ile Ser Thr Lys Met Glu 
465                 470                 475                 480 


Asp Ser Gly Val Tyr Leu Cys Glu Gly Ile Asn Gln Ala Gly Arg Ser 
                485                 490                 495     


Arg Lys Glu Val Glu Leu Ile Ile Gln Val Thr Pro Lys Asp Ile Lys 
            500                 505                 510         


Leu Thr Ala Phe Pro Ser Glu Ser Val Lys Glu Gly Asp Thr Val Ile 
        515                 520                 525             


Ile Ser Cys Thr Cys Gly Asn Val Pro Glu Thr Trp Ile Ile Leu Lys 
    530                 535                 540                 


Lys Lys Ala Glu Thr Gly Asp Thr Val Leu Lys Ser Ile Asp Gly Ala 
545                 550                 555                 560 


Tyr Thr Ile Arg Lys Ala Gln Leu Lys Asp Ala Gly Val Tyr Glu Cys 
                565                 570                 575     


Glu Ser Lys Asn Lys Val Gly Ser Gln Leu Arg Ser Leu Thr Leu Asp 
            580                 585                 590         


Val Gln Gly Arg Glu Asn Asn Lys Asp Tyr Phe Ser Pro Glu Leu Leu 
        595                 600                 605             


Val Leu Tyr Phe Ala Ser Ser Leu Ile Ile Pro Ala Ile Gly Met Ile 
    610                 615                 620                 


Ile Tyr Phe Ala Arg Lys Ala Asn Met Lys Gly Ser Tyr Ser Leu Val 
625                 630                 635                 640 


Glu Ala Gln Lys Ser Lys Val 
                645         


<210>  3
<211>  677
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  isoform c of CD106 human

<400>  3

Met Pro Gly Lys Met Val Val Ile Leu Gly Ala Ser Asn Ile Leu Trp 
1               5                   10                  15      


Ile Met Phe Ala Ala Ser Gln Ala Phe Lys Ile Glu Thr Thr Pro Glu 
            20                  25                  30          


Ser Arg Tyr Leu Ala Gln Ile Gly Asp Ser Val Ser Leu Thr Cys Ser 
        35                  40                  45              


Thr Thr Gly Ser Phe Pro Lys Asp Pro Glu Ile His Leu Ser Gly Pro 
    50                  55                  60                  


Leu Glu Ala Gly Lys Pro Ile Thr Val Lys Cys Ser Val Ala Asp Val 
65                  70                  75                  80  


Tyr Pro Phe Asp Arg Leu Glu Ile Asp Leu Leu Lys Gly Asp His Leu 
                85                  90                  95      


Met Lys Ser Gln Glu Phe Leu Glu Asp Ala Asp Arg Lys Ser Leu Glu 
            100                 105                 110         


Thr Lys Ser Leu Glu Val Thr Phe Thr Pro Val Ile Glu Asp Ile Gly 
        115                 120                 125             


Lys Val Leu Val Cys Arg Ala Lys Leu His Ile Asp Glu Met Asp Ser 
    130                 135                 140                 


Val Pro Thr Val Arg Gln Ala Val Lys Glu Leu Gln Val Tyr Ile Ser 
145                 150                 155                 160 


Pro Lys Asn Thr Val Ile Ser Val Asn Pro Ser Thr Lys Leu Gln Glu 
                165                 170                 175     


Gly Gly Ser Val Thr Met Thr Cys Ser Ser Glu Gly Leu Pro Ala Pro 
            180                 185                 190         


Glu Ile Phe Trp Ser Lys Lys Leu Asp Asn Gly Asn Leu Gln His Leu 
        195                 200                 205             


Ser Gly Asn Ala Thr Leu Thr Leu Ile Ala Met Arg Met Glu Asp Ser 
    210                 215                 220                 


Gly Ile Tyr Val Cys Glu Gly Val Asn Leu Ile Gly Lys Asn Arg Lys 
225                 230                 235                 240 


Glu Val Glu Leu Ile Val Gln Glu Lys Pro Phe Thr Val Glu Ile Ser 
                245                 250                 255     


Pro Gly Pro Arg Ile Ala Ala Gln Ile Gly Asp Ser Val Met Leu Thr 
            260                 265                 270         


Cys Ser Val Met Gly Cys Glu Ser Pro Ser Phe Ser Trp Arg Thr Gln 
        275                 280                 285             


Ile Asp Ser Pro Leu Ser Gly Lys Val Arg Ser Glu Gly Thr Asn Ser 
    290                 295                 300                 


Thr Leu Thr Leu Ser Pro Val Ser Phe Glu Asn Glu His Ser Tyr Leu 
305                 310                 315                 320 


Cys Thr Val Thr Cys Gly His Lys Lys Leu Glu Lys Gly Ile Gln Val 
                325                 330                 335     


Glu Leu Tyr Ser Phe Pro Arg Asp Pro Glu Ile Glu Met Ser Gly Gly 
            340                 345                 350         


Leu Val Asn Gly Ser Ser Val Thr Val Ser Cys Lys Val Pro Ser Val 
        355                 360                 365             


Tyr Pro Leu Asp Arg Leu Glu Ile Glu Leu Leu Lys Gly Glu Thr Ile 
    370                 375                 380                 


Leu Glu Asn Ile Glu Phe Leu Glu Asp Thr Asp Met Lys Ser Leu Glu 
385                 390                 395                 400 


Asn Lys Ser Leu Glu Met Thr Phe Ile Pro Thr Ile Glu Asp Thr Gly 
                405                 410                 415     


Lys Ala Leu Val Cys Gln Ala Lys Leu His Ile Asp Asp Met Glu Phe 
            420                 425                 430         


Glu Pro Lys Gln Arg Gln Ser Thr Gln Thr Leu Tyr Val Asn Val Ala 
        435                 440                 445             


Pro Arg Asp Thr Thr Val Leu Val Ser Pro Ser Ser Ile Leu Glu Glu 
    450                 455                 460                 


Gly Ser Ser Val Asn Met Thr Cys Leu Ser Gln Gly Phe Pro Ala Pro 
465                 470                 475                 480 


Lys Ile Leu Trp Ser Arg Gln Leu Pro Asn Gly Glu Leu Gln Pro Leu 
                485                 490                 495     


Ser Glu Asn Ala Thr Leu Thr Leu Ile Ser Thr Lys Met Glu Asp Ser 
            500                 505                 510         


Gly Val Tyr Leu Cys Glu Gly Ile Asn Gln Ala Gly Arg Ser Arg Lys 
        515                 520                 525             


Glu Val Glu Leu Ile Ile Gln Val Thr Pro Lys Asp Ile Lys Leu Thr 
    530                 535                 540                 


Ala Phe Pro Ser Glu Ser Val Lys Glu Gly Asp Thr Val Ile Ile Ser 
545                 550                 555                 560 


Cys Thr Cys Gly Asn Val Pro Glu Thr Trp Ile Ile Leu Lys Lys Lys 
                565                 570                 575     


Ala Glu Thr Gly Asp Thr Val Leu Lys Ser Ile Asp Gly Ala Tyr Thr 
            580                 585                 590         


Ile Arg Lys Ala Gln Leu Lys Asp Ala Gly Val Tyr Glu Cys Glu Ser 
        595                 600                 605             


Lys Asn Lys Val Gly Ser Gln Leu Arg Ser Leu Thr Leu Asp Val Gln 
    610                 615                 620                 


Gly Arg Glu Asn Asn Lys Asp Tyr Phe Ser Pro Glu Leu Leu Val Leu 
625                 630                 635                 640 


Tyr Phe Ala Ser Ser Leu Ile Ile Pro Ala Ile Gly Met Ile Ile Tyr 
                645                 650                 655     


Phe Ala Arg Lys Ala Asn Met Lys Gly Ser Tyr Ser Leu Val Glu Ala 
            660                 665                 670         


Gln Lys Ser Lys Val 
        675         


<210>  4
<211>  1621
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Nestin human

<400>  4

Met Glu Gly Cys Met Gly Glu Glu Ser Phe Gln Met Trp Glu Leu Asn 
1               5                   10                  15      


Arg Arg Leu Glu Ala Tyr Leu Ala Arg Val Lys Ala Leu Glu Glu Gln 
            20                  25                  30          


Asn Glu Leu Leu Ser Ala Glu Leu Gly Gly Leu Arg Ala Gln Ser Ala 
        35                  40                  45              


Asp Thr Ser Trp Arg Ala His Ala Asp Asp Glu Leu Ala Ala Leu Arg 
    50                  55                  60                  


Ala Leu Val Asp Gln Arg Trp Arg Glu Lys His Ala Ala Glu Val Ala 
65                  70                  75                  80  


Arg Asp Asn Leu Ala Glu Glu Leu Glu Gly Val Ala Gly Arg Cys Gln 
                85                  90                  95      


Gln Leu Arg Leu Ala Arg Glu Arg Thr Thr Glu Glu Val Ala Arg Asn 
            100                 105                 110         


Arg Arg Ala Val Glu Ala Glu Lys Cys Ala Arg Ala Trp Leu Ser Ser 
        115                 120                 125             


Gln Val Ala Glu Leu Glu Arg Glu Leu Glu Ala Leu Arg Val Ala His 
    130                 135                 140                 


Glu Glu Glu Arg Val Gly Leu Asn Ala Gln Ala Ala Cys Ala Pro Arg 
145                 150                 155                 160 


Cys Pro Ala Pro Pro Arg Gly Pro Pro Ala Pro Ala Pro Glu Val Glu 
                165                 170                 175     


Glu Leu Ala Arg Arg Leu Gly Glu Ala Trp Arg Gly Ala Val Arg Gly 
            180                 185                 190         


Tyr Gln Glu Arg Val Ala His Met Glu Thr Ser Leu Gly Gln Ala Arg 
        195                 200                 205             


Glu Arg Leu Gly Arg Ala Val Gln Gly Ala Arg Glu Gly Arg Leu Glu 
    210                 215                 220                 


Leu Gln Gln Leu Gln Ala Glu Arg Gly Gly Leu Leu Glu Arg Arg Ala 
225                 230                 235                 240 


Ala Leu Glu Gln Arg Leu Glu Gly Arg Trp Gln Glu Arg Leu Arg Ala 
                245                 250                 255     


Thr Glu Lys Phe Gln Leu Ala Val Glu Ala Leu Glu Gln Glu Lys Gln 
            260                 265                 270         


Gly Leu Gln Ser Gln Ile Ala Gln Val Leu Glu Gly Arg Gln Gln Leu 
        275                 280                 285             


Ala His Leu Lys Met Ser Leu Ser Leu Glu Val Ala Thr Tyr Arg Thr 
    290                 295                 300                 


Leu Leu Glu Ala Glu Asn Ser Arg Leu Gln Thr Pro Gly Gly Gly Ser 
305                 310                 315                 320 


Lys Thr Ser Leu Ser Phe Gln Asp Pro Lys Leu Glu Leu Gln Phe Pro 
                325                 330                 335     


Arg Thr Pro Glu Gly Arg Arg Leu Gly Ser Leu Leu Pro Val Leu Ser 
            340                 345                 350         


Pro Thr Ser Leu Pro Ser Pro Leu Pro Ala Thr Leu Glu Thr Pro Val 
        355                 360                 365             


Pro Ala Phe Leu Lys Asn Gln Glu Phe Leu Gln Ala Arg Thr Pro Thr 
    370                 375                 380                 


Leu Ala Ser Thr Pro Ile Pro Pro Thr Pro Gln Ala Pro Ser Pro Ala 
385                 390                 395                 400 


Val Asp Ala Glu Ile Arg Ala Gln Asp Ala Pro Leu Ser Leu Leu Gln 
                405                 410                 415     


Thr Gln Gly Gly Arg Lys Gln Ala Pro Glu Pro Leu Arg Ala Glu Ala 
            420                 425                 430         


Arg Val Ala Ile Pro Ala Ser Val Leu Pro Gly Pro Glu Glu Pro Gly 
        435                 440                 445             


Gly Gln Arg Gln Glu Ala Ser Thr Gly Gln Ser Pro Glu Asp His Ala 
    450                 455                 460                 


Ser Leu Ala Pro Pro Leu Ser Pro Asp His Ser Ser Leu Glu Ala Lys 
465                 470                 475                 480 


Asp Gly Glu Ser Gly Gly Ser Arg Val Phe Ser Ile Cys Arg Gly Glu 
                485                 490                 495     


Gly Glu Gly Gln Ile Trp Gly Leu Val Glu Lys Glu Thr Ala Ile Glu 
            500                 505                 510         


Gly Lys Val Val Ser Ser Leu Gln Gln Glu Ile Trp Glu Glu Glu Asp 
        515                 520                 525             


Leu Asn Arg Lys Glu Ile Gln Asp Ser Gln Val Pro Leu Glu Lys Glu 
    530                 535                 540                 


Thr Leu Lys Ser Leu Gly Glu Glu Ile Gln Glu Ser Leu Lys Thr Leu 
545                 550                 555                 560 


Glu Asn Gln Ser His Glu Thr Leu Glu Arg Glu Asn Gln Glu Cys Pro 
                565                 570                 575     


Arg Ser Leu Glu Glu Asp Leu Glu Thr Leu Lys Ser Leu Glu Lys Glu 
            580                 585                 590         


Asn Lys Glu Leu Leu Lys Asp Val Glu Val Val Arg Pro Leu Glu Lys 
        595                 600                 605             


Glu Ala Val Gly Gln Leu Lys Pro Thr Gly Lys Glu Asp Thr Gln Thr 
    610                 615                 620                 


Leu Gln Ser Leu Gln Lys Glu Asn Gln Glu Leu Met Lys Ser Leu Glu 
625                 630                 635                 640 


Gly Asn Leu Glu Thr Phe Leu Phe Pro Gly Thr Glu Asn Gln Glu Leu 
                645                 650                 655     


Val Ser Ser Leu Gln Glu Asn Leu Glu Ser Leu Thr Ala Leu Glu Lys 
            660                 665                 670         


Glu Asn Gln Glu Pro Leu Arg Ser Pro Glu Val Gly Asp Glu Glu Ala 
        675                 680                 685             


Leu Arg Pro Leu Thr Lys Glu Asn Gln Glu Pro Leu Arg Ser Leu Glu 
    690                 695                 700                 


Asp Glu Asn Lys Glu Ala Phe Arg Ser Leu Glu Lys Glu Asn Gln Glu 
705                 710                 715                 720 


Pro Leu Lys Thr Leu Glu Glu Glu Asp Gln Ser Ile Val Arg Pro Leu 
                725                 730                 735     


Glu Thr Glu Asn His Lys Ser Leu Arg Ser Leu Glu Glu Gln Asp Gln 
            740                 745                 750         


Glu Thr Leu Arg Thr Leu Glu Lys Glu Thr Gln Gln Arg Arg Arg Ser 
        755                 760                 765             


Leu Gly Glu Gln Asp Gln Met Thr Leu Arg Pro Pro Glu Lys Val Asp 
    770                 775                 780                 


Leu Glu Pro Leu Lys Ser Leu Asp Gln Glu Ile Ala Arg Pro Leu Glu 
785                 790                 795                 800 


Asn Glu Asn Gln Glu Phe Leu Lys Ser Leu Lys Glu Glu Ser Val Glu 
                805                 810                 815     


Ala Val Lys Ser Leu Glu Thr Glu Ile Leu Glu Ser Leu Lys Ser Ala 
            820                 825                 830         


Gly Gln Glu Asn Leu Glu Thr Leu Lys Ser Pro Glu Thr Gln Ala Pro 
        835                 840                 845             


Leu Trp Thr Pro Glu Glu Ile Asn Gln Gly Ala Met Asn Pro Leu Glu 
    850                 855                 860                 


Lys Glu Ile Gln Glu Pro Leu Glu Ser Val Glu Val Asn Gln Glu Thr 
865                 870                 875                 880 


Phe Arg Leu Leu Glu Glu Glu Asn Gln Glu Ser Leu Arg Ser Leu Gly 
                885                 890                 895     


Ala Trp Asn Leu Glu Asn Leu Arg Ser Pro Glu Glu Val Asp Lys Glu 
            900                 905                 910         


Ser Gln Arg Asn Leu Glu Glu Glu Glu Asn Leu Gly Lys Gly Glu Tyr 
        915                 920                 925             


Gln Glu Ser Leu Arg Ser Leu Glu Glu Glu Gly Gln Glu Leu Pro Gln 
    930                 935                 940                 


Ser Ala Asp Val Gln Arg Trp Glu Asp Thr Val Glu Lys Asp Gln Glu 
945                 950                 955                 960 


Leu Ala Gln Glu Ser Pro Pro Gly Met Ala Gly Val Glu Asn Glu Asp 
                965                 970                 975     


Glu Ala Glu Leu Asn Leu Arg Glu Gln Asp Gly Phe Thr Gly Lys Glu 
            980                 985                 990         


Glu Val Val Glu Gln Gly Glu Leu  Asn Ala Thr Glu Glu  Val Trp Ile 
        995                 1000                 1005             


Pro Gly  Glu Gly His Pro Glu  Ser Pro Glu Pro Lys  Glu Gln Arg 
    1010                 1015                 1020             


Gly Leu  Val Glu Gly Ala Ser  Val Lys Gly Gly Ala  Glu Gly Leu 
    1025                 1030                 1035             


Gln Asp  Pro Glu Gly Gln Ser  Gln Gln Val Gly Ala  Pro Gly Leu 
    1040                 1045                 1050             


Gln Ala  Pro Gln Gly Leu Pro  Glu Ala Ile Glu Pro  Leu Val Glu 
    1055                 1060                 1065             


Asp Asp  Val Ala Pro Gly Gly  Asp Gln Ala Ser Pro  Glu Val Met 
    1070                 1075                 1080             


Leu Gly  Ser Glu Pro Ala Met  Gly Glu Ser Ala Ala  Gly Ala Glu 
    1085                 1090                 1095             


Pro Gly  Pro Gly Gln Gly Val  Gly Gly Leu Gly Asp  Pro Gly His 
    1100                 1105                 1110             


Leu Thr  Arg Glu Glu Val Met  Glu Pro Pro Leu Glu  Glu Glu Ser 
    1115                 1120                 1125             


Leu Glu  Ala Lys Arg Val Gln  Gly Leu Glu Gly Pro  Arg Lys Asp 
    1130                 1135                 1140             


Leu Glu  Glu Ala Gly Gly Leu  Gly Thr Glu Phe Ser  Glu Leu Pro 
    1145                 1150                 1155             


Gly Lys  Ser Arg Asp Pro Trp  Glu Pro Pro Arg Glu  Gly Arg Glu 
    1160                 1165                 1170             


Glu Ser  Glu Ala Glu Ala Pro  Arg Gly Ala Glu Glu  Ala Phe Pro 
    1175                 1180                 1185             


Ala Glu  Thr Leu Gly His Thr  Gly Ser Asp Ala Pro  Ser Pro Trp 
    1190                 1195                 1200             


Pro Leu  Gly Ser Glu Glu Ala  Glu Glu Asp Val Pro  Pro Val Leu 
    1205                 1210                 1215             


Val Ser  Pro Ser Pro Thr Tyr  Thr Pro Ile Leu Glu  Asp Ala Pro 
    1220                 1225                 1230             


Gly Pro  Gln Pro Gln Ala Glu  Gly Ser Gln Glu Ala  Ser Trp Gly 
    1235                 1240                 1245             


Val Gln  Gly Arg Ala Glu Ala  Leu Gly Lys Val Glu  Ser Glu Gln 
    1250                 1255                 1260             


Glu Glu  Leu Gly Ser Gly Glu  Ile Pro Glu Gly Pro  Gln Glu Glu 
    1265                 1270                 1275             


Gly Glu  Glu Ser Arg Glu Glu  Ser Glu Glu Asp Glu  Leu Gly Glu 
    1280                 1285                 1290             


Thr Leu  Pro Asp Ser Thr Pro  Leu Gly Phe Tyr Leu  Arg Ser Pro 
    1295                 1300                 1305             


Thr Ser  Pro Arg Trp Asp Pro  Thr Gly Glu Gln Arg  Pro Pro Pro 
    1310                 1315                 1320             


Gln Gly  Glu Thr Gly Lys Glu  Gly Trp Asp Pro Ala  Val Leu Ala 
    1325                 1330                 1335             


Ser Glu  Gly Leu Glu Ala Pro  Pro Ser Glu Lys Glu  Glu Gly Glu 
    1340                 1345                 1350             


Glu Gly  Glu Glu Glu Cys Gly  Arg Asp Ser Asp Leu  Ser Glu Glu 
    1355                 1360                 1365             


Phe Glu  Asp Leu Gly Thr Glu  Ala Pro Phe Leu Pro  Gly Val Pro 
    1370                 1375                 1380             


Gly Glu  Val Ala Glu Pro Leu  Gly Gln Val Pro Gln  Leu Leu Leu 
    1385                 1390                 1395             


Asp Pro  Ala Ala Trp Asp Arg  Asp Gly Glu Ser Asp  Gly Phe Ala 
    1400                 1405                 1410             


Asp Glu  Glu Glu Ser Gly Glu  Glu Gly Glu Glu Asp  Gln Glu Glu 
    1415                 1420                 1425             


Gly Arg  Glu Pro Gly Ala Gly  Arg Trp Gly Pro Gly  Ser Ser Val 
    1430                 1435                 1440             


Gly Ser  Leu Gln Ala Leu Ser  Ser Ser Gln Arg Gly  Glu Phe Leu 
    1445                 1450                 1455             


Glu Ser  Asp Ser Val Ser Val  Ser Val Pro Trp Asp  Asp Ser Leu 
    1460                 1465                 1470             


Arg Gly  Ala Val Ala Gly Ala  Pro Lys Thr Ala Leu  Glu Thr Glu 
    1475                 1480                 1485             


Ser Gln  Asp Ser Ala Glu Pro  Ser Gly Ser Glu Glu  Glu Ser Asp 
    1490                 1495                 1500             


Pro Val  Ser Leu Glu Arg Glu  Asp Lys Val Pro Gly  Pro Leu Glu 
    1505                 1510                 1515             


Ile Pro  Ser Gly Met Glu Asp  Ala Gly Pro Gly Ala  Asp Ile Ile 
    1520                 1525                 1530             


Gly Val  Asn Gly Gln Gly Pro  Asn Leu Glu Gly Lys  Ser Gln His 
    1535                 1540                 1545             


Val Asn  Gly Gly Val Met Asn  Gly Leu Glu Gln Ser  Glu Glu Val 
    1550                 1555                 1560             


Gly Gln  Gly Met Pro Leu Val  Ser Glu Gly Asp Arg  Gly Ser Pro 
    1565                 1570                 1575             


Phe Gln  Glu Glu Glu Gly Ser  Ala Leu Lys Thr Ser  Trp Ala Gly 
    1580                 1585                 1590             


Ala Pro  Val His Leu Gly Gln  Gly Gln Phe Leu Lys  Phe Thr Gln 
    1595                 1600                 1605             


Arg Glu  Gly Asp Arg Glu Ser  Trp Ser Ser Gly Glu  Asp 
    1610                 1615                 1620     


<210>  5
<211>  253
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CD151 human

<400>  5

Met Gly Glu Phe Asn Glu Lys Lys Thr Thr Cys Gly Thr Val Cys Leu 
1               5                   10                  15      


Lys Tyr Leu Leu Phe Thr Tyr Asn Cys Cys Phe Trp Leu Ala Gly Leu 
            20                  25                  30          


Ala Val Met Ala Val Gly Ile Trp Thr Leu Ala Leu Lys Ser Asp Tyr 
        35                  40                  45              


Ile Ser Leu Leu Ala Ser Gly Thr Tyr Leu Ala Thr Ala Tyr Ile Leu 
    50                  55                  60                  


Val Val Ala Gly Thr Val Val Met Val Thr Gly Val Leu Gly Cys Cys 
65                  70                  75                  80  


Ala Thr Phe Lys Glu Arg Arg Asn Leu Leu Arg Leu Tyr Phe Ile Leu 
                85                  90                  95      


Leu Leu Ile Ile Phe Leu Leu Glu Ile Ile Ala Gly Ile Leu Ala Tyr 
            100                 105                 110         


Ala Tyr Tyr Gln Gln Leu Asn Thr Glu Leu Lys Glu Asn Leu Lys Asp 
        115                 120                 125             


Thr Met Thr Lys Arg Tyr His Gln Pro Gly His Glu Ala Val Thr Ser 
    130                 135                 140                 


Ala Val Asp Gln Leu Gln Gln Glu Phe His Cys Cys Gly Ser Asn Asn 
145                 150                 155                 160 


Ser Gln Asp Trp Arg Asp Ser Glu Trp Ile Arg Ser Gln Glu Ala Gly 
                165                 170                 175     


Gly Arg Val Val Pro Asp Ser Cys Cys Lys Thr Val Val Ala Leu Cys 
            180                 185                 190         


Gly Gln Arg Asp His Ala Ser Asn Ile Tyr Lys Val Glu Gly Gly Cys 
        195                 200                 205             


Ile Thr Lys Leu Glu Thr Phe Ile Gln Glu His Leu Arg Val Ile Gly 
    210                 215                 220                 


Ala Val Gly Ile Gly Ile Ala Cys Val Gln Val Phe Gly Met Ile Phe 
225                 230                 235                 240 


Thr Cys Cys Leu Tyr Arg Ser Leu Lys Leu Glu His Tyr 
                245                 250             


<210>  6
<211>  269
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IL1beta human

<400>  6

Met Ala Glu Val Pro Glu Leu Ala Ser Glu Met Met Ala Tyr Tyr Ser 
1               5                   10                  15      


Gly Asn Glu Asp Asp Leu Phe Phe Glu Ala Asp Gly Pro Lys Gln Met 
            20                  25                  30          


Lys Cys Ser Phe Gln Asp Leu Asp Leu Cys Pro Leu Asp Gly Gly Ile 
        35                  40                  45              


Gln Leu Arg Ile Ser Asp His His Tyr Ser Lys Gly Phe Arg Gln Ala 
    50                  55                  60                  


Ala Ser Val Val Val Ala Met Asp Lys Leu Arg Lys Met Leu Val Pro 
65                  70                  75                  80  


Cys Pro Gln Thr Phe Gln Glu Asn Asp Leu Ser Thr Phe Phe Pro Phe 
                85                  90                  95      


Ile Phe Glu Glu Glu Pro Ile Phe Phe Asp Thr Trp Asp Asn Glu Ala 
            100                 105                 110         


Tyr Val His Asp Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp 
        115                 120                 125             


Ser Gln Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala 
    130                 135                 140                 


Leu His Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met 
145                 150                 155                 160 


Ser Phe Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu 
                165                 170                 175     


Gly Leu Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp 
            180                 185                 190         


Lys Pro Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys 
        195                 200                 205             


Lys Lys Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn 
    210                 215                 220                 


Lys Leu Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr 
225                 230                 235                 240 


Ser Gln Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly 
                245                 250                 255     


Gln Asp Ile Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
            260                 265                 


<210>  7
<211>  153
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  IL4 human

<400>  7

Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
1               5                   10                  15      


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
            20                  25                  30          


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
        35                  40                  45              


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
    50                  55                  60                  


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
65                  70                  75                  80  


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
                85                  90                  95      


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
            100                 105                 110         


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
        115                 120                 125             


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
    130                 135                 140                 


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
145                 150             


