                         SEQUENCE LISTING

<110>  Singapore Health Services Pte. Ltd
       National University of Singapore
       Clegg, Richard I
 
<120>  IL-11Ralpha Antibodies

<130>  RIC/FP7324841

<150>  GB1621439.7
<151>  2016-12-16

<160>  99    

<170>  PatentIn version 3.5

<210>  1
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_1

<400>  1

Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Ser Val Ser Met Lys 
1               5                   10                  15      


Phe Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_2

<400>  2

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Gly Tyr Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-2E5

<400>  3

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Ser 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ala Ser Leu Glu Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Arg Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Gln Gln Tyr Ala Ser Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  4
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-4G3

<400>  4

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Ser Val Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Ser 
            20                  25                  30          


Gly Thr Thr Leu Met Gln Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Gly Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Asp Asp Ile Ala Met Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      


Lys Val Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  5
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-5E5

<400>  5

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Pro Val Ser Val Gly 
1               5                   10                  15      


Glu Asn Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Gly 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Tyr Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  6
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-7G9

<400>  6

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         


<210>  7
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-9A7

<400>  7

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Met Thr Pro Gly 
1               5                   10                  15      


Asp Ser Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Asn 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Phe Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Val Tyr Phe Cys Gln Gln Arg Tyr Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Met Lys 
            100                 105         


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-10D11

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Glu Ile Ser Ala Tyr 
            20                  25                  30          


Leu Ser Trp Leu Gln Gln Lys Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ser Thr Ser Thr Leu Asp Ser Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Asp Tyr Phe Cys Leu Gln Tyr Ala Ser Ser Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-13B10

<400>  9

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Ser Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Ala Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  10
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_1

<400>  10

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Thr Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Asn Asn 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asn Ser Gly Ile Thr Asn Ile Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asn Lys Ala Thr Val Thr Val Asp Lys Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Arg Ser Asp Gly Thr Tyr Glu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Pro Leu Thr Val Ser Ser 
        115                 


<210>  11
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_2

<400>  11

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Asn Phe Asn Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Asn Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Arg Ile Ile Thr Tyr Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Val Gly Glu Gly Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Leu Thr Val Ser Ser 
        115         


<210>  12
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-2E5

<400>  12

Gln Gly Gln Val Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Ser Thr Ser 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Lys Pro Arg Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ala Gly Thr Gly Ser Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Gln Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Trp Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ala 
    


<210>  13
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-4G3

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Lys Ser Asn Gly Gly Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala His Gly Leu Leu Phe Ala His Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  14
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-5E5

<400>  14

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Ser Ser Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Val Gly Tyr Tyr Tyr Val Ser Asp Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Thr Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  15
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-7G9

<400>  15

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Asn Ser Gly Tyr Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ile Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala His 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr His Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Ser Tyr Gly Pro Trp Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  16
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-9A7

<400>  16

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met His Trp Leu Lys Gln Arg Pro Val Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Gly Pro Ser Asp Ser Lys Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Tyr Val Leu Phe Thr Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-10D11

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Val Arg Pro Gly Thr 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ala Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile Gly Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Phe Pro Gly Gly Asp Tyr Thr Lys Cys Ser Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Lys Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Ser Thr Thr Ile Arg Phe Gly Ala Met Asp Asn Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-13B10

<400>  18

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Phe 
            20                  25                  30          


Ser Ile Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Gly Ile Trp Thr Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Lys 
    50                  55                  60                  


Pro Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Arg Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asn Ser Asn Tyr Pro Ser Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ala 
        115             


<210>  19
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_1 CDR1 Light Chain

<400>  19

Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  20
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_1 CDR2 Light Chain

<400>  20

Lys Val Ser 
1           


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_1 CDR3 Light Chain

<400>  21

Ser Gln Ser Thr His Val Pro Leu Thr 
1               5                   


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_2 CDR1 Light Chain

<400>  22

Glu Asn Val Gly Thr Tyr 
1               5       


<210>  23
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_2 CDR2 Light Chain

<400>  23

Gly Ala Ser 
1           


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_2 CDR3 Light Chain

<400>  24

Gly Gln Gly Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  25
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-2E5 CDR1 Light Chain

<400>  25

Gln Asp Ile Gly Ser Ser 
1               5       


<210>  26
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-2E5 CDR2 Light Chain

<400>  26

Ala Thr Ala 
1           


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-2E5 CDR3 Light Chain

<400>  27

Gln Gln Tyr Ala Ser Ser Pro Pro Thr 
1               5                   


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-4G3 CDR1 Light Chain

<400>  28

Glu Ser Val Glu Tyr Ser Gly Thr Thr Leu 
1               5                   10  


<210>  29
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-4G3 CDR3 Light Chain

<400>  29

Gln Gln Ser Arg Lys Val Pro Tyr Thr 
1               5                   


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-5E5 CDR1 Light Chain

<400>  30

Gln Ser Leu Leu Tyr Gly Ser Asn Gln Lys Asn Tyr 
1               5                   10          


<210>  31
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-5E5 CDR2 Light Chain

<400>  31

Trp Ala Ser 
1           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-5E5 CDR3 Light Chain

<400>  32

Gln Gln Tyr Tyr Ser Tyr Pro Arg Thr 
1               5                   


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-9A7 CDR1 Light Chain

<400>  33

Gln Ser Ile Ser Asn Asn 
1               5       


<210>  34
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-9A7 CDR2 Light Chain

<400>  34

Tyr Ala Ser 
1           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-9A7 CDR3 Light Chain

<400>  35

Gln Gln Arg Tyr Ser Trp Pro Leu Thr 
1               5                   


<210>  36
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-10D11 CDR1 Light Chain

<400>  36

Gln Glu Ile Ser Ala Tyr 
1               5       


<210>  37
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-10D11 CDR2 Light Chain

<400>  37

Ser Thr Ser 
1           


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-10D11 CDR3 Light Chain

<400>  38

Leu Gln Tyr Ala Ser Ser Pro Leu Thr 
1               5                   


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-13B10 CDR1 Light Chain

<400>  39

Gln Asn Val Gly Ser Asn 
1               5       


<210>  40
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-13B10 CDR2 Light Chain

<400>  40

Ser Ala Ser 
1           


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-13B10 CDR3 Light Chain

<400>  41

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_1 CDR1 Heavy Chain

<400>  42

Gly Phe Thr Phe Thr Asn Asn Trp 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_1 CDR2 Heavy Chain

<400>  43

Ile His Pro Asn Ser Gly Ile Thr 
1               5               


<210>  44
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_1 CDR3 Heavy Chain

<400>  44

Arg Ser Asp Gly Thr Tyr Glu Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  45
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_2 CDR1 Heavy Chain

<400>  45

Gly Tyr Asn Phe Asn Asp Tyr Tyr 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_2 CDR2 Heavy Chain

<400>  46

Ile Phe Pro Gly Arg Ile Ile Thr 
1               5               


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_1 CDR3 Heavy Chain

<400>  47

Ala Arg Gly Val Gly Glu Gly Phe Asp Tyr 
1               5                   10  


<210>  48
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO 2E5 CDR1 Heavy Chain

<400>  48

Gly Phe Thr Phe Ser Thr Ser Tyr 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-2E5 CDR2 Heavy Chain

<400>  49

Ile Tyr Ala Gly Thr Gly Ser Thr 
1               5               


<210>  50
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-2E5 CDR3 Heavy Chain

<400>  50

Ala Arg His Trp Ala Tyr 
1               5       


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-4G3 CDR1 Heavy Chain

<400>  51

Gly Phe Thr Phe Ser Thr Tyr Ala 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-4G3 CDR2 Heavy Chain

<400>  52

Ile Lys Ser Asn Gly Gly Ser Thr 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-4G3 CDR3 Heavy Chain

<400>  53

Ala His Gly Leu Leu Phe Ala His 
1               5               


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-5E5 CDR1 Heavy Chain

<400>  54

Gly Tyr Ser Ile Thr Ser Asp Tyr Tyr 
1               5                   


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-5E5 CDR2 Heavy Chain

<400>  55

Ile Ser Tyr Asp Ser Ser Asn 
1               5           


<210>  56
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-5E5 CDR3 Heavy Chain

<400>  56

Ala Ser Val Gly Tyr Tyr Tyr Val Ser Asp Trp Tyr Phe Asp Val 
1               5                   10                  15  


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-7G9 CDR1 Heavy Chain

<400>  57

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-7G9 CDR2 Heavy Chain

<400>  58

Ile His Pro Asn Ser Gly Tyr Thr 
1               5               


<210>  59
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-7G9 CDR3 Heavy Chain

<400>  59

Ala Arg Gly Gly Tyr Asp Gly Ser Tyr Gly Pro Trp Phe Ala Tyr 
1               5                   10                  15  


<210>  60
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-9A7 CDR1 Heavy Chain

<400>  60

Gly Tyr Thr Phe Thr Asn Tyr Trp 
1               5               


<210>  61
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-9A7 CDR2 Heavy Chain

<400>  61

Ile Gly Pro Ser Asp Ser Lys Thr 
1               5               


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-9A7 CDR3 Heavy Chain

<400>  62

Ala Arg Gly Asp Tyr Val Leu Phe Thr Tyr 
1               5                   10  


<210>  63
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-10D11 CDR1 Heavy Chain

<400>  63

Gly Tyr Thr Phe Thr Asp Tyr Trp 
1               5               


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-10D11 CDR2 Heavy Chain

<400>  64

Ile Phe Pro Gly Gly Asp Tyr Thr 
1               5               


<210>  65
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-10D11 CDR3 Heavy Chain

<400>  65

Ala Arg Arg Ser Thr Thr Ile Arg Phe Gly Ala Met Asp Asn 
1               5                   10                  


<210>  66
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-13B10 CDR1 Heavy Chain

<400>  66

Gly Phe Ser Leu Thr Ser Phe Ser 
1               5               


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-13B10 CDR2 Heavy Chain

<400>  67

Ile Trp Thr Gly Gly Gly Thr 
1               5           


<210>  68
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-13B10 CDR3 Heavy Chain

<400>  68

Ala Arg Asn Ser Asn Tyr Pro Ser Gly Phe Ala Tyr 
1               5                   10          


<210>  69
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-9A7, BSO-10D11, BSO-13B10, BSO-2E5 LC-CDR1-1 Family consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = N, S, E or D

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = I or V

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = G or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = S, N or A

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = N, Y or S

<400>  69

Gln Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  70
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-5E5, BSO-1E3_1, BSO-7G9 LC-CDR1-2 Family Consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = Absent or L

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = V or Y

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = H or G

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = G or Q

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = N or K

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = T or N

<400>  70

Gln Ser Leu Xaa Xaa Xaa Ser Asn Xaa Xaa Xaa Tyr 
1               5                   10          


<210>  71
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-4G3, BSO-1E3_2, BSO-5E5, BSO-9A7, BSO-13B10 LC-CDR2-1 Family 
       Consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = G, W, Y or S

<400>  71

Xaa Ala Ser 
1           


<210>  72
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-10D11, BSO-1E3_1, BSO-7G9 LC-CDR2-2 Family Consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = S or K

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = T or V

<400>  72

Xaa Xaa Ser 
1           


<210>  73
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_1, BSO-7G9, BSO-1E3_2, BSO-2E5, BSO-4G3, BSO-5E5, 
       BSO-9A7, BSO-10D11, BSo-13B10 LC-CDR3-1 Family Consensus


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  X = Q, S, G or L

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = Y, S, G or R

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = Y, A, T, N or R

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = S, H or K

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = V, Y, S or W

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = L, Y, R or P

<400>  73

Xaa Gln Xaa Xaa Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-7G9, BSO-9A7, BSO-10D11 HC-CDR1-1 Family Consensus


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = S, N or D

<400>  74

Gly Tyr Thr Phe Thr Xaa Tyr Trp 
1               5               


<210>  75
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-2E5, BSO-4G3, BSO-1E3_1 HC-CDR1-2 Family Consensus


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = S or T

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = T or N

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = S, Y or N

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = Y, A or W

<400>  75

Gly Phe Thr Phe Xaa Xaa Xaa Xaa 
1               5               


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-5E5, BSO-1E3_2 HC-CDR1-3 Family Consensus


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = S or N

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = I or F

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = T or N

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = Absent or S

<400>  76

Gly Tyr Xaa Xaa Xaa Xaa Asp Tyr Tyr 
1               5                   


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_1, BSO-4G3, BSO-2E5, BSO-7G9 HC-CDR2-1 Family Consensus


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  X = H, K or Y

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X = P, S or A

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = N or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = S, G or T

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = S, I or Y

<400>  77

Ile Xaa Xaa Xaa Xaa Gly Xaa Thr 
1               5               


<210>  78
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_2, BSO-10D11 HC-CDR2-2 Family Consensus


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = R or G

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = I or D

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = I or Y

<400>  78

Ile Phe Pro Gly Xaa Xaa Xaa Thr 
1               5               


<210>  79
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BSO-7G9, BSO-1E3_2, BSO-9A7 HC-CDR3-1 Family Consensus


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  X = Absent, D or G

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  X = Absent or Y

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  X = V or D

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X = G or L

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X = Absent, E or S

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X = Absent or Y

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X = Absent or G

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X = Absent or P

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X = Absent or W

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X = D, T or A

<400>  79

Ala Arg Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Xaa Tyr 
1               5                   10                  15  


<210>  80
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_1

<400>  80
gatgttgtga tgacccaaat tccactctcc ctgtctgtca gtatgaagtt ccaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

ctcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  81
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-1ES_2

<400>  81
aacattgtaa tgacccaatc tcccaaatcc atgtccatgt cagtaggaga gagggtcacc       60

ttgagctgca aggccagtga gaatgtgggt acttatgtat cctggtatca acagaaacca      120

gagcagtctc ctaaactgct gatatacggg gcatccaacc ggtacactgg ggtccccgat      180

cgcttcacag gcagtggatc tgcaacagat ttcactctga ccatcagcag tgtgcaggct      240

gaagaccttg cagattatca ctgtggacag ggttacagct atccgtacac gttcggaggg      300

gggaccaagc tggaaataaa a                                                321


<210>  82
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-2E5

<400>  82
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt       60

ctcacttgtc gggcaagtca ggacattggt agtagcttaa actggcttca gcaggaacca      120

gatggaacta ttaaacgcct gatctacgcc acagccagtt tagaatctgg tgtccccaaa      180

aggttcagtg gcagtaggtc tgggtcagac tattctctca ccatcagcag acttgagtct      240

gaagattttg tagactatta ctgtcaacaa tatgctagct ctcctcccac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  83
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-4G3

<400>  83
gacattgtgc tcacccaatc tccagcttct ttggctgtgt ctctagggca gagtgtcacc       60

atctcctgca gagccagtga aagtgttgaa tattctggca ctactttaat gcagtggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg gtgcatccaa cgtagaatct      180

ggggtccctg ccaggtttag tggcagtggg tctgggacag acttcagcct caacatccat      240

cctgtggagg aggatgatat tgcaatgtat ttctgtcagc aaagtaggaa ggttccgtat      300

acgttcggat cggggaccaa gctggaaata aaa                                   333


<210>  84
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-5E5

<400>  84
gacattgtga tgtcacagtc tccatcctcc ctacctgtgt cagttggaga gaatgttact       60

atgagctgca agtccagtca gagcctttta tatggtagca atcaaaagaa ctacttggcc      120

tggtaccagc agaaaccagg gcagtctcct aaactgctga tttactgggc atccactagg      180

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      240

atcagcagtg tgaaggctga agacctggca gtttatttct gtcagcaata ttatagctat      300

cctcggacgt tcggtggagg caccaagctg gaaatcaaa                             339


<210>  85
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-7G9

<400>  85
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

ctcacgttcg gtgctgggac caagctggag ctgaaa                                336


<210>  86
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-9A7

<400>  86
gatattgtgc taactcagtc tccagccacc ctgtctatga ctccaggaga tagcgtcagt       60

ctttcctgca gggccagcca aagtattagc aacaacctac actggtatca acaaaaatca      120

catgagtctc caaggcttct catcaagtat gcttcccagt ccatctctgg gatcccctcc      180

aggttcagtg gcagtggatc ggggacagat ttcactctca gtttcaacag tgtggagact      240

gaagattttg gagtgtattt ctgtcaacag agatacagct ggcctctcac gttcggtgct      300

gggaccaagc tggaaatgaa a                                                321


<210>  87
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-10D11

<400>  87
gacatccaga tgacccagtc tccatcctcc ttatctgcct ctctgggaga aagagtcagt       60

ctcacttgtc gggcaagtca ggaaattagt gcttacttaa gctggcttca gcagaaacca      120

gatggaacta ttaaacgcct gatctacagc acatccactt tagattctgg tgtcccaaaa      180

aggttcagtg gcagtaggtc tgggtcagat tattctctca ccatcagcag ccttgagtct      240

gaagattttg cagactattt ctgtctccaa tatgctagtt ctccgctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  88
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-13B10

<400>  88
gacattgtga tgacccagtc tcaaaaattc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgtgggt agtaatgtag cctggtatca acagaaagca      120

gggcaatctc ctaaagcact gatttactcg gcatcctacc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagacttgg cagagtattt ctgtcagcaa tataacagct atccgctcac gttcggtgct      300

gggaccaagc tggagctgaa a                                                321


<210>  89
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_1

<400>  89
caggtccaac tgcagcagcc tggggctgaa ctggtcacgc ctggggcttc agtgaagttg       60

tcctgcaagg cttctggctt cactttcacc aacaactgga tgcactgggt gaagcagaga      120

cctggacaag gccttgagtg gattggaatg attcatccta atagtgggat tactaacatc      180

aatgagaagt tcaagaacaa ggccacagtg actgtagaca aatcctccag cacagtctac      240

atacaactca gcagcctgac atctgaggac tctgcggtct attactgtcg ctccgatggt      300

acctacgagg gctactttga ctactggggc caaggcaccc ctctcacagt ctcctca         357


<210>  90
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-1E3_2

<400>  90
caggtccaac tacagcagtc tggacctgaa ctggtgaagc ctggggcttc agtgaagata       60

tcctgcaagg cttctggcta caatttcaat gactactata taaactgggt gaaccagagg      120

cctggacagg gacttgagtg gattggatgg atttttcctg gaagaattat tacttactac      180

aatgagaaat tcaagggcaa ggccacactt actgtagaca catcctccaa cacagcctac      240

atgttgctca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aagaggggta      300

ggagagggct ttgactactg gggccaaggc accactctca cagtctcctc a               351


<210>  91
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-2E5

<400>  91
cagggtcagg tgcagcagtc tggagctgag ctggtgaagc ctggggcttc agtgaagctg       60

tcctgcaaga cttctggctt caccttcagt actagttata taagttggtt gaagcagaag      120

cctcgacaga gtcttgagtg gattgcatgg atttatgctg gaactggtag tactagctat      180

aatcagaaat tcacaggcaa ggcccaactg actgtagaca catcctccag cacagcctac      240

atgcaactca gcagcctgac atctgaggac tctgccatct attactgtgc aagacactgg      300

gcttactggg gccaagggac tctggtcact gtctctgca                             339


<210>  92
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-4G3

<400>  92
gaggtgcagc tggtggagtc tgggggaggc ttagtgaagc ctggcgggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt acctatgcca tgtcttgggt tcgccagact      120

ccagagaaga ggctggagtg ggtcgcagcc attaaaagta atggtggtag cacctactat      180

ccagacactg tgaaggaccg attcaccatt tccagagaca atgccaagaa caccctgtac      240

ctgcaaatga gcagtctgag gcctgaggac acagccttgt attactgtgc acatggtctc      300

ctgtttgctc actggggcca agggactctg gtcactgtct ctgca                      345


<210>  93
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-5E5


<220>
<221>  misc_feature
<222>  (352)..(352)
<223>  n is a, c, g, or t

<400>  93
gatgtacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc       60

acctgctctg tcactggcta ctccatcacc agtgattatt actggaactg gatccggcag      120

tttccaggaa acaaactgga atggatgggc tacataagct acgatagtag caataactac      180

aacccatctc tcaaaaatcg aatctccatc actcgtgaca catctaagaa ccagtttttc      240

ctgaagttga attctgtgac tactgaggac acagccacat attactgtgc ttcagtgggt      300

tattactacg ttagtgactg gtacttcgat gtctggggca cagggaccac gntcaccgtc      360

tcctca                                                                 366


<210>  94
<211>  366
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-7G9

<400>  94
caggtccaac tgcagcagcc tggggctgag ctggtaaagc ctggggcttc agtgaggttg       60

tcctgcaagg cttctggcta cactttcacc agctactgga tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggaatg attcatccta atagtggtta tactaattac      180

aatgagaagt tcaagatcaa ggccacactg actgtagaca aatcctccag cacagcccac      240

atgcaactca gcagcctgac atctgaggat tctgcggtct atcactgtgc aagagggggg      300

tatgatggtt cctacgggcc ctggtttgct tactggggcc aagggactct ggtcactgtc      360

tctgca                                                                 366


<210>  95
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-9A7

<400>  95
caggtccaac tgcagcagcc tggggctgag ctggtgaggc ctgggtcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc aactactgga tgcattggtt gaagcagagg      120

cctgtacaag gccttgagtg gattggtaac attggccctt ctgatagtaa aactcactac      180

aatcaaaaat tcaaggacaa ggccacattg actgtagaca aatcctccag cacagcctac      240

atgcaactca acagcctgac atctgaggac tctgcggtct attactgtgc aaggggtgat      300

tacgtcctgt ttacttactg gggccaaggg actctggtca ctgtctctgc a               351


<210>  96
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-10D11

<400>  96
caggtccagc tgcagcagtc tggaactgag ctggtaaggc ctgggacttc agtgaagatg       60

tcctgcaagg ctgctggata caccttcact gactactgga taggttggat aaagcagagg      120

cctggacatg gccttgagtg gattggagat attttccctg gaggtgatta tactaagtgc      180

agtgagaggt tcaagggcaa ggccaaactg actgcagaca catcctccag cactgcctac      240

atgcagctca gcagactgac atctgaggac tctgccatct attactgtgc aagaaggagt      300

actacgatac gcttcggggc tatggacaac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  97
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BSO-13B10

<400>  97
caggtgcagc tgaaggagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acatgcactg tctctgggtt ctcattaacc agcttttcta taagctgggt tcgccagcca      120

ccaggaaagg gtctggagtg gcttggagga atatggactg gtggaggcac aaattataat      180

tcagctctca aacccagact gagcatcagc aaagacaact ccaagagtca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccaggtact actgtgccag aaatagtaac      300

tacccttccg ggtttgctta ctggggccaa gggactctgg tcactgtctc tgca            354


<210>  98
<211>  1575
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-11:IL-11Ralpha fusion protein

<400>  98
gaattcccgc cgccaccatg ggctggtcct gcatcatcct gtttctggtg gccacagcca       60

ccggcgtgca ctctccacag gcttggggac ctccaggcgt gcagtatggc cagcctggca      120

gatccgtgaa gctgtgctgt cctggcgtga cagctggcga ccctgtgtcc tggttcagag      180

atggcgagcc caagctgctg cagggcccag attctggact gggccacgaa ctggtgctgg      240

cccaggccga ttctaccgac gagggcacct acatctgcca gaccctggat ggcgccctgg      300

gcggaacagt gacactgcag ctgggctacc ctcccgccag acctgtggtg tcttgtcagg      360

ccgccgacta cgagaacttc agctgcacat ggtcccccag ccagatcagc ggcctgccca      420

ccagatacct gaccagctac cggaagaaaa ccgtgctggg cgccgacagc cagagaagaa      480

gcccttctac aggcccctgg ccctgccctc aggatcctct gggagctgcc agatgtgtgg      540

tgcacggcgc cgagttctgg tcccagtacc ggatcaacgt gaccgaagtg aaccccctgg      600

gcgcctccac aagactgctg gatgtgtccc tgcagagcat cctgcggccc gatcctccac      660

agggcctgag agtggaaagc gtgcccggct accccagaag gctgagagcc agctggacat      720

accccgcctc ttggccttgc cagccccact tcctgctgaa gtttcggctg cagtaccggc      780

cagcccagca ccctgcttgg agcacagtgg aacctgccgg cctggaagaa gtgatcacag      840

acgccgtggc cggactgcct catgctgtgc gggtgtccgc cagagacttt ctggatgccg      900

gcacctggtc tacctggtcc ccagaagcct ggggcacacc ttctactggc ggacctgctg      960

gacagtctgg cggaggcgga ggaagtggcg gaggatcagg gggaggatct gtgcctggac     1020

ctcctccagg accccctaga gtgtccccag atcctagggc cgagctggac tctaccgtgc     1080

tgctgaccag atccctgctg gccgacacaa ggcagctggc tgcccagctg agagacaagt     1140

tccccgccga cggcgaccac aacctggata gcctgcctac cctggccatg tctgctggcg     1200

cactgggggc tctgcagctg cctggggtgc tgactagact gagagccgac ctgctgagct     1260

acctgcggca tgtgcagtgg ctgagaaggg ctggcggcag cagcctgaaa accctggaac     1320

ctgagctggg cacactgcag gccagactgg acagactgct gcgcagactg cagctgctga     1380

tgagcagact ggctctgccc cagcctcctc ctgaccctcc tgctcctcca ctggctcctc     1440

caagctctgc ttggggcgga attagagccg cccacgccat tctgggaggc ctgcacctga     1500

cactggattg ggcagtgcgg ggcctgctgc tgctgaaaac cagactgcac caccaccatc     1560

accactgata agctt                                                      1575


<210>  99
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-11:IL-11Ralpha fusion protein

<400>  99

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Pro Gln Ala Trp Gly Pro Pro Gly Val Gln Tyr Gly Gln 
            20                  25                  30          


Pro Gly Arg Ser Val Lys Leu Cys Cys Pro Gly Val Thr Ala Gly Asp 
        35                  40                  45              


Pro Val Ser Trp Phe Arg Asp Gly Glu Pro Lys Leu Leu Gln Gly Pro 
    50                  55                  60                  


Asp Ser Gly Leu Gly His Glu Leu Val Leu Ala Gln Ala Asp Ser Thr 
65                  70                  75                  80  


Asp Glu Gly Thr Tyr Ile Cys Gln Thr Leu Asp Gly Ala Leu Gly Gly 
                85                  90                  95      


Thr Val Thr Leu Gln Leu Gly Tyr Pro Pro Ala Arg Pro Val Val Ser 
            100                 105                 110         


Cys Gln Ala Ala Asp Tyr Glu Asn Phe Ser Cys Thr Trp Ser Pro Ser 
        115                 120                 125             


Gln Ile Ser Gly Leu Pro Thr Arg Tyr Leu Thr Ser Tyr Arg Lys Lys 
    130                 135                 140                 


Thr Val Leu Gly Ala Asp Ser Gln Arg Arg Ser Pro Ser Thr Gly Pro 
145                 150                 155                 160 


Trp Pro Cys Pro Gln Asp Pro Leu Gly Ala Ala Arg Cys Val Val His 
                165                 170                 175     


Gly Ala Glu Phe Trp Ser Gln Tyr Arg Ile Asn Val Thr Glu Val Asn 
            180                 185                 190         


Pro Leu Gly Ala Ser Thr Arg Leu Leu Asp Val Ser Leu Gln Ser Ile 
        195                 200                 205             


Leu Arg Pro Asp Pro Pro Gln Gly Leu Arg Val Glu Ser Val Pro Gly 
    210                 215                 220                 


Tyr Pro Arg Arg Leu Arg Ala Ser Trp Thr Tyr Pro Ala Ser Trp Pro 
225                 230                 235                 240 


Cys Gln Pro His Phe Leu Leu Lys Phe Arg Leu Gln Tyr Arg Pro Ala 
                245                 250                 255     


Gln His Pro Ala Trp Ser Thr Val Glu Pro Ala Gly Leu Glu Glu Val 
            260                 265                 270         


Ile Thr Asp Ala Val Ala Gly Leu Pro His Ala Val Arg Val Ser Ala 
        275                 280                 285             


Arg Asp Phe Leu Asp Ala Gly Thr Trp Ser Thr Trp Ser Pro Glu Ala 
    290                 295                 300                 


Trp Gly Thr Pro Ser Thr Gly Gly Pro Ala Gly Gln Ser Gly Gly Gly 
305                 310                 315                 320 


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Val Pro Gly Pro Pro 
                325                 330                 335     


Pro Gly Pro Pro Arg Val Ser Pro Asp Pro Arg Ala Glu Leu Asp Ser 
            340                 345                 350         


Thr Val Leu Leu Thr Arg Ser Leu Leu Ala Asp Thr Arg Gln Leu Ala 
        355                 360                 365             


Ala Gln Leu Arg Asp Lys Phe Pro Ala Asp Gly Asp His Asn Leu Asp 
    370                 375                 380                 


Ser Leu Pro Thr Leu Ala Met Ser Ala Gly Ala Leu Gly Ala Leu Gln 
385                 390                 395                 400 


Leu Pro Gly Val Leu Thr Arg Leu Arg Ala Asp Leu Leu Ser Tyr Leu 
                405                 410                 415     


Arg His Val Gln Trp Leu Arg Arg Ala Gly Gly Ser Ser Leu Lys Thr 
            420                 425                 430         


Leu Glu Pro Glu Leu Gly Thr Leu Gln Ala Arg Leu Asp Arg Leu Leu 
        435                 440                 445             


Arg Arg Leu Gln Leu Leu Met Ser Arg Leu Ala Leu Pro Gln Pro Pro 
    450                 455                 460                 


Pro Asp Pro Pro Ala Pro Pro Leu Ala Pro Pro Ser Ser Ala Trp Gly 
465                 470                 475                 480 


Gly Ile Arg Ala Ala His Ala Ile Leu Gly Gly Leu His Leu Thr Leu 
                485                 490                 495     


Asp Trp Ala Val Arg Gly Leu Leu Leu Leu Lys Thr Arg Leu His His 
            500                 505                 510         


His His His His 
        515     


