                         SEQUENCE LISTING

<110>  UEA Enterprises Limited
 
<120>  Method for nucleic acid depletion

<130>  1617990P/PCT

<150>  GB1621271.4
<151>  2016-12-14

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  398
<212>  PRT
<213>  Clostridium perfringens

<400>  1

Met Lys Arg Lys Ile Cys Lys Ala Leu Ile Cys Ala Ala Leu Ala Thr 
1               5                   10                  15      


Ser Leu Trp Ala Gly Ala Ser Thr Lys Val Tyr Ala Trp Asp Gly Lys 
            20                  25                  30          


Ile Asp Gly Thr Gly Thr His Ala Met Ile Val Thr Gln Gly Val Ser 
        35                  40                  45              


Ile Leu Glu Asn Asp Met Ser Lys Asn Glu Pro Glu Ser Val Arg Lys 
    50                  55                  60                  


Asn Leu Glu Ile Leu Lys Glu Asn Met His Glu Leu Gln Leu Gly Ser 
65                  70                  75                  80  


Thr Tyr Pro Asp Tyr Asp Lys Asn Ala Tyr Asp Leu Tyr Gln Asp His 
                85                  90                  95      


Phe Trp Asp Pro Asp Thr Asp Asn Asn Phe Ser Lys Asp Asn Ser Trp 
            100                 105                 110         


Tyr Leu Ala Tyr Ser Ile Pro Asp Thr Gly Glu Ser Gln Ile Arg Lys 
        115                 120                 125             


Phe Ser Ala Leu Ala Arg Tyr Glu Trp Gln Arg Gly Asn Tyr Lys Gln 
    130                 135                 140                 


Ala Thr Phe Tyr Leu Gly Glu Ala Met His Tyr Phe Gly Asp Ile Asp 
145                 150                 155                 160 


Thr Pro Tyr His Pro Ala Asn Val Thr Ala Val Asp Ser Ala Gly His 
                165                 170                 175     


Val Lys Phe Glu Thr Phe Ala Glu Glu Arg Lys Glu Gln Tyr Lys Ile 
            180                 185                 190         


Asn Thr Ala Gly Cys Lys Thr Asn Glu Asp Phe Tyr Ala Asp Ile Leu 
        195                 200                 205             


Lys Asn Lys Asp Phe Asn Ala Trp Ser Lys Glu Tyr Ala Arg Gly Phe 
    210                 215                 220                 


Ala Lys Thr Gly Lys Ser Ile Tyr Tyr Ser His Ala Ser Met Ser His 
225                 230                 235                 240 


Ser Trp Asp Asp Trp Asp Tyr Ala Ala Lys Val Thr Leu Ala Asn Ser 
                245                 250                 255     


Gln Lys Gly Thr Ala Gly Tyr Ile Tyr Arg Phe Leu His Asp Val Ser 
            260                 265                 270         


Glu Gly Asn Asp Pro Ser Val Gly Lys Asn Val Lys Glu Leu Val Ala 
        275                 280                 285             


Tyr Ile Ser Thr Ser Gly Glu Lys Asp Ala Gly Thr Asp Asp Tyr Met 
    290                 295                 300                 


Tyr Phe Gly Ile Lys Thr Lys Asp Gly Lys Thr Gln Glu Trp Glu Met 
305                 310                 315                 320 


Asp Asn Pro Gly Asn Asp Phe Met Thr Gly Ser Lys Asp Thr Tyr Thr 
                325                 330                 335     


Phe Lys Leu Lys Asp Glu Asn Leu Lys Ile Asp Asp Ile Gln Asn Met 
            340                 345                 350         


Trp Ile Arg Lys Arg Lys Tyr Thr Ala Phe Pro Asp Ala Tyr Lys Pro 
        355                 360                 365             


Glu Asn Ile Lys Val Ile Ala Asn Gly Lys Val Val Val Asp Lys Asp 
    370                 375                 380                 


Ile Asn Glu Trp Ile Ser Gly Asn Ser Thr Tyr Asn Ile Lys 
385                 390                 395             


<210>  2
<211>  319
<212>  PRT
<213>  Staphylococcus aureus

<400>  2

Met Lys Thr Arg Ile Val Ser Ser Val Thr Thr Thr Leu Leu Leu Gly 
1               5                   10                  15      


Cys Ile Leu Met Asn Pro Val Ala Asn Ala Ala Asp Ser Asp Ile Asn 
            20                  25                  30          


Ile Lys Thr Gly Thr Thr Asp Ile Gly Ser Asn Thr Thr Val Lys Thr 
        35                  40                  45              


Gly Asp Leu Val Thr Tyr Asp Lys Glu Asn Gly Met His Lys Lys Val 
    50                  55                  60                  


Phe Tyr Ser Phe Ile Asp Asp Lys Asn His Asn Lys Lys Ile Leu Val 
65                  70                  75                  80  


Ile Arg Thr Lys Gly Thr Ile Ala Gly Gln Tyr Arg Val Tyr Ser Glu 
                85                  90                  95      


Glu Gly Ala Asn Lys Ser Gly Leu Ala Trp Pro Ser Ala Phe Lys Val 
            100                 105                 110         


Gln Leu Gln Leu Pro Asp Asn Glu Val Ala Gln Ile Ser Asp Tyr Tyr 
        115                 120                 125             


Pro Arg Asn Ser Ile Asp Thr Lys Glu Tyr Met Ser Thr Leu Thr Tyr 
    130                 135                 140                 


Gly Phe Asn Gly Asn Val Thr Gly Asp Asp Ser Gly Lys Ile Gly Gly 
145                 150                 155                 160 


Leu Ile Gly Ala Asn Val Ser Ile Gly His Thr Leu Lys Tyr Val Gln 
                165                 170                 175     


Pro Asp Phe Lys Thr Ile Leu Glu Ser Pro Thr Asp Lys Lys Val Gly 
            180                 185                 190         


Trp Lys Val Ile Phe Asn Asn Met Val Asn Gln Asn Trp Gly Pro Tyr 
        195                 200                 205             


Asp Arg Asp Ser Trp Asn Pro Val Tyr Gly Asn Gln Leu Phe Met Lys 
    210                 215                 220                 


Thr Arg Asn Gly Ser Met Lys Ala Ala Asp Asn Phe Leu Asp Pro Asn 
225                 230                 235                 240 


Lys Ala Ser Ser Leu Leu Ser Ser Gly Phe Ser Pro Asp Phe Ala Thr 
                245                 250                 255     


Val Ile Thr Met Asp Arg Lys Ala Ser Lys Gln Gln Thr Asn Ile Asp 
            260                 265                 270         


Val Ile Tyr Glu Arg Val Arg Asp Asp Tyr Gln Leu Tyr Trp Thr Ser 
        275                 280                 285             


Thr Asn Trp Lys Gly Thr Asn Thr Lys Asp Lys Trp Thr Asp Arg Ser 
    290                 295                 300                 


Ser Glu Arg Tyr Lys Ile Asp Trp Glu Lys Glu Glu Met Thr Asn 
305                 310                 315                 


<210>  3
<211>  571
<212>  PRT
<213>  Streptococcus pyogenes

<400>  3

Met Ser Asn Lys Lys Thr Phe Lys Lys Tyr Ser Arg Val Ala Gly Leu 
1               5                   10                  15      


Leu Thr Ala Ala Leu Ile Ile Gly Asn Leu Val Thr Ala Asn Ala Glu 
            20                  25                  30          


Ser Asn Lys Gln Asn Thr Ala Ser Thr Glu Thr Thr Thr Thr Ser Glu 
        35                  40                  45              


Gln Pro Lys Pro Glu Ser Ser Glu Leu Thr Ile Glu Lys Ala Gly Gln 
    50                  55                  60                  


Lys Met Asp Asp Met Leu Asn Ser Asn Asp Met Ile Lys Leu Ala Pro 
65                  70                  75                  80  


Lys Glu Met Pro Leu Glu Ser Ala Glu Lys Glu Glu Lys Lys Ser Glu 
                85                  90                  95      


Asp Lys Lys Lys Ser Glu Glu Asp His Thr Glu Glu Ile Asn Asp Lys 
            100                 105                 110         


Ile Tyr Ser Leu Asn Tyr Asn Glu Leu Glu Val Leu Ala Lys Asn Gly 
        115                 120                 125             


Glu Thr Ile Glu Asn Phe Val Pro Lys Glu Gly Val Lys Lys Ala Asp 
    130                 135                 140                 


Lys Phe Ile Val Ile Glu Arg Lys Lys Lys Asn Ile Asn Thr Thr Pro 
145                 150                 155                 160 


Val Asp Ile Ser Ile Ile Asp Ser Val Thr Asp Arg Thr Tyr Pro Ala 
                165                 170                 175     


Ala Leu Gln Leu Ala Asn Lys Gly Phe Thr Glu Asn Lys Pro Asp Ala 
            180                 185                 190         


Val Val Thr Lys Arg Asn Pro Gln Lys Ile His Ile Asp Leu Pro Gly 
        195                 200                 205             


Met Gly Asp Lys Ala Thr Val Glu Val Asn Asp Pro Thr Tyr Ala Asn 
    210                 215                 220                 


Val Ser Thr Ala Ile Asp Asn Leu Val Asn Gln Trp His Asp Asn Tyr 
225                 230                 235                 240 


Ser Gly Gly Asn Thr Leu Pro Ala Arg Thr Gln Tyr Thr Glu Ser Met 
                245                 250                 255     


Val Tyr Ser Lys Ser Gln Ile Glu Ala Ala Leu Asn Val Asn Ser Lys 
            260                 265                 270         


Ile Leu Asp Gly Thr Leu Gly Ile Asp Phe Lys Ser Ile Ser Lys Gly 
        275                 280                 285             


Glu Lys Lys Val Met Ile Ala Ala Tyr Lys Gln Ile Phe Tyr Thr Val 
    290                 295                 300                 


Ser Ala Asn Leu Pro Asn Asn Pro Ala Asp Val Phe Asp Lys Ser Val 
305                 310                 315                 320 


Thr Phe Lys Asp Leu Gln Arg Lys Gly Val Ser Asn Glu Ala Pro Pro 
                325                 330                 335     


Leu Phe Val Ser Asn Val Ala Tyr Gly Arg Thr Val Phe Val Lys Leu 
            340                 345                 350         


Glu Thr Ser Ser Lys Ser Asn Asp Val Glu Ala Ala Phe Ser Ala Ala 
        355                 360                 365             


Leu Lys Gly Thr Asp Val Lys Thr Asn Gly Lys Tyr Ser Asp Ile Leu 
    370                 375                 380                 


Glu Asn Ser Ser Phe Thr Ala Val Val Leu Gly Gly Asp Ala Ala Glu 
385                 390                 395                 400 


His Asn Lys Val Val Thr Lys Asp Phe Asp Val Ile Arg Asn Val Ile 
                405                 410                 415     


Lys Asp Asn Ala Thr Phe Ser Arg Lys Asn Pro Ala Tyr Pro Ile Ser 
            420                 425                 430         


Tyr Thr Ser Val Phe Leu Lys Asn Asn Lys Ile Ala Gly Val Asn Asn 
        435                 440                 445             


Arg Thr Glu Tyr Val Glu Thr Thr Ser Thr Glu Tyr Thr Ser Gly Lys 
    450                 455                 460                 


Ile Asn Leu Ser His Gln Gly Ala Tyr Val Ala Gln Tyr Glu Ile Leu 
465                 470                 475                 480 


Trp Asp Glu Ile Asn Tyr Asp Asp Lys Gly Lys Glu Val Ile Thr Lys 
                485                 490                 495     


Arg Arg Trp Asp Asn Asn Trp Tyr Ser Lys Thr Ser Pro Phe Ser Thr 
            500                 505                 510         


Val Ile Pro Leu Gly Ala Asn Ser Arg Asn Ile Arg Ile Met Ala Arg 
        515                 520                 525             


Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Lys Val Ile Asp Glu 
    530                 535                 540                 


Arg Asp Val Lys Leu Ser Lys Glu Ile Asn Val Asn Ile Ser Gly Ser 
545                 550                 555                 560 


Thr Leu Ser Pro Tyr Gly Ser Ile Thr Tyr Lys 
                565                 570     


<210>  4
<211>  331
<212>  PRT
<213>  Staphylococcus aureus

<400>  4

Met Met Val Lys Lys Thr Lys Ser Asn Ser Leu Lys Lys Val Ala Thr 
1               5                   10                  15      


Leu Ala Leu Ala Asn Leu Leu Leu Val Gly Ala Leu Thr Asp Asn Ser 
            20                  25                  30          


Ala Lys Ala Glu Ser Lys Lys Asp Asp Thr Asp Leu Lys Leu Val Ser 
        35                  40                  45              


His Asn Val Tyr Met Leu Ser Thr Val Leu Tyr Pro Asn Trp Gly Gln 
    50                  55                  60                  


Tyr Lys Arg Ala Asp Leu Ile Gly Gln Ser Ser Tyr Ile Lys Asn Asn 
65                  70                  75                  80  


Asp Val Val Ile Phe Asn Glu Ala Phe Asp Asn Gly Ala Ser Asp Lys 
                85                  90                  95      


Leu Leu Ser Asn Val Lys Lys Glu Tyr Pro Tyr Gln Thr Pro Val Leu 
            100                 105                 110         


Gly Arg Ser Gln Ser Gly Trp Asp Lys Thr Glu Gly Ser Tyr Ser Ser 
        115                 120                 125             


Thr Val Ala Glu Asp Gly Gly Val Ala Ile Val Ser Lys Tyr Pro Ile 
    130                 135                 140                 


Lys Glu Lys Ile Gln His Val Phe Lys Ser Gly Cys Gly Phe Asp Asn 
145                 150                 155                 160 


Asp Ser Asn Lys Gly Phe Val Tyr Thr Lys Ile Glu Lys Asn Gly Lys 
                165                 170                 175     


Asn Val His Val Ile Gly Thr His Thr Gln Ser Glu Asp Ser Arg Cys 
            180                 185                 190         


Gly Ala Gly His Asp Arg Lys Ile Arg Ala Glu Gln Met Lys Glu Ile 
        195                 200                 205             


Ser Asp Phe Val Lys Lys Lys Asn Ile Pro Lys Asp Glu Thr Val Tyr 
    210                 215                 220                 


Ile Gly Gly Asp Leu Asn Val Asn Lys Gly Thr Pro Glu Phe Lys Asp 
225                 230                 235                 240 


Met Leu Lys Asn Leu Asn Val Asn Asp Val Leu Tyr Ala Gly His Asn 
                245                 250                 255     


Ser Thr Trp Asp Pro Gln Ser Asn Ser Ile Ala Lys Tyr Asn Tyr Pro 
            260                 265                 270         


Asn Gly Lys Pro Glu His Leu Asp Tyr Ile Phe Thr Asp Lys Asp His 
        275                 280                 285             


Lys Gln Pro Lys Gln Leu Val Asn Glu Val Val Thr Glu Lys Pro Lys 
    290                 295                 300                 


Pro Trp Asp Val Tyr Ala Phe Pro Tyr Tyr Tyr Val Tyr Asn Asp Phe 
305                 310                 315                 320 


Ser Asp His Tyr Pro Ile Lys Ala Tyr Ser Lys 
                325                 330     


<210>  5
<211>  553
<212>  PRT
<213>  Streptomyces vinaceus

<400>  5

Met His Arg His Thr Pro Ser Leu Arg Arg Pro Ser Ala His Leu Pro 
1               5                   10                  15      


Ser Ala Leu Ala Val Arg Ala Ala Val Pro Ala Ala Leu Leu Ala Leu 
            20                  25                  30          


Phe Ala Ala Val Pro Ala Ser Ala Ala Pro Ala Ala Gly Ser Gly Ala 
        35                  40                  45              


Asp Pro Ala Pro His Leu Asp Ala Val Glu Gln Thr Leu Arg Gln Val 
    50                  55                  60                  


Ser Pro Gly Leu Glu Gly Gln Val Trp Glu Arg Thr Ala Gly Asn Val 
65                  70                  75                  80  


Leu Asp Ala Ser Thr Pro Gly Gly Ala Asp Trp Leu Leu Gln Thr Pro 
                85                  90                  95      


Gly Cys Trp Gly Asp Asp Lys Cys Thr Ala Arg Pro Gly Thr Glu Gln 
            100                 105                 110         


Leu Leu Ser Lys Met Thr Gln Asn Ile Ser Gln Ala Thr Arg Thr Val 
        115                 120                 125             


Asp Ile Ser Thr Leu Ala Pro Phe Pro Asn Gly Ala Phe Gln Asp Ala 
    130                 135                 140                 


Ile Val Ser Gly Leu Lys Thr Ser Ala Ala Arg Gly Asn Lys Leu Lys 
145                 150                 155                 160 


Val Arg Val Leu Val Gly Ala Ala Pro Val Tyr His Leu Asn Val Leu 
                165                 170                 175     


Pro Ser Lys Tyr Arg Asp Glu Leu Val Ala Lys Leu Gly Ala Asp Ala 
            180                 185                 190         


Arg Asn Val Asp Leu Asn Val Ala Ser Met Thr Thr Ser Lys Thr Ala 
        195                 200                 205             


Phe Ser Trp Asn His Ser Lys Leu Leu Val Val Asp Gly Gln Ser Val 
    210                 215                 220                 


Ile Thr Gly Gly Ile Asn Asp Trp Lys Asp Asp Tyr Leu Glu Thr Ala 
225                 230                 235                 240 


His Pro Val Ala Asp Val Asp Leu Ala Leu Arg Gly Pro Ala Ala Ala 
                245                 250                 255     


Ser Ala Gly Arg Tyr Leu Asp Glu Leu Trp Ser Trp Thr Cys Gln Asn 
            260                 265                 270         


Lys Ser Asn Ile Ala Ser Val Trp Phe Ala Ser Ser Asn Gly Ala Ala 
        275                 280                 285             


Cys Met Pro Ala Met Ala Lys Asp Thr Ala Pro Ala Ala Pro Ala Pro 
    290                 295                 300                 


Ala Pro Gly Asp Val Pro Ala Val Ala Val Gly Gly Leu Gly Val Gly 
305                 310                 315                 320 


Ile Lys Arg Asn Asp Pro Ser Ser Ser Phe Arg Pro Ala Leu Pro Ser 
                325                 330                 335     


Ala Pro Asp Thr Lys Cys Val Val Gly Leu His Asp Asn Thr Asn Ala 
            340                 345                 350         


Asp Arg Asp Tyr Asp Thr Val Asn Pro Glu Glu Ser Ala Leu Arg Thr 
        355                 360                 365             


Leu Ile Ser Ser Ala Asn Arg His Ile Glu Ile Ser Gln Gln Asp Val 
    370                 375                 380                 


Asn Ala Thr Cys Pro Pro Leu Pro Arg Tyr Asp Ile Arg Val Tyr Asp 
385                 390                 395                 400 


Ala Leu Ala Ala Arg Met Ala Ala Gly Val Lys Val Arg Ile Val Val 
                405                 410                 415     


Ser Asp Pro Ala Asn Arg Gly Ala Val Gly Ser Gly Gly Tyr Ser Gln 
            420                 425                 430         


Ile Lys Ser Leu Ser Glu Ile Ser Asp Thr Leu Arg Asp Arg Leu Ala 
        435                 440                 445             


Leu Val Thr Gly Asp Gln Gly Ala Ala Lys Ala Thr Met Cys Ser Asn 
    450                 455                 460                 


Leu Gln Leu Ala Thr Phe Arg Ser Ser Gln Ser Pro Thr Trp Ala Asp 
465                 470                 475                 480 


Gly His Pro Tyr Ala Gln His His Lys Val Val Ser Val Asp Asp Ser 
                485                 490                 495     


Ala Phe Tyr Ile Gly Ser Lys Asn Leu Tyr Pro Ala Trp Leu Gln Asp 
            500                 505                 510         


Phe Gly Tyr Val Val Glu Ser Pro Ala Ala Ala Ala Gln Leu Asn Ala 
        515                 520                 525             


Arg Leu Leu Ala Pro Gln Trp Gln Tyr Ser Arg Ala Thr Ala Thr Ile 
    530                 535                 540                 


Asp His Glu Arg Ala Leu Cys Gln Ser 
545                 550             


