                         SEQUENCE LISTING

<110>  National institute for biotechnology of the negev
 
<120>  FUSION PROTEINS FOR TREATMENT OF CANCER

<130>  NIBN-P-15-PC

<150>  IL 249610
<151>  2016-12-15

<160>  43    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic seequence


<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is methionine or valine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  X is alanine or aspartic acid

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  X is alanine or aspartic acid

<400>  1

Glu Ala Ser Ala Leu Val Cys Ile Arg Leu Val Thr Ser Ser Lys Pro 
1               5                   10                  15      


Arg Thr Xaa Ala Trp Thr Ser Arg Phe Thr Ile Trp Xaa Xaa 
            20                  25                  30  


<210>  2
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is methionine or valine

<400>  2

Val Thr Ser Ser Lys Pro Arg Thr Xaa Ala 
1               5                   10  


<210>  3
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  3

Glu Ala Ser Ala Leu Val Cys Ile Arg Leu Val Thr Ser Ser Lys Pro 
1               5                   10                  15      


Arg Thr Val Ala 
            20  


<210>  4
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  4

Glu Ala Ser Ala Leu Val Cys Ile Arg Leu Val Thr Ser Ser Lys Pro 
1               5                   10                  15      


Arg Thr Met Ala 
            20  


<210>  5
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is alanine or aspartic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is alanine or aspartic acid

<400>  5

Val Thr Ser Ser Lys Pro Arg Thr Val Ala Trp Thr Ser Arg Phe Thr 
1               5                   10                  15      


Ile Trp Xaa Xaa 
            20  


<210>  6
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is alanine or aspartic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is alanine or aspartic acid

<400>  6

Val Thr Ser Ser Lys Pro Arg Thr Met Ala Trp Thr Ser Arg Phe Thr 
1               5                   10                  15      


Ile Trp Xaa Xaa 
            20  


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  7

Lys Lys Lys Arg Arg 
1               5   


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  8

Pro Lys Lys Lys Arg Arg Val 
1               5           


<210>  9
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  9

Lys Arg Arg Met Lys Trp Lys Lys 
1               5               


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  10

Lys Lys Lys Arg Lys 
1               5   


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  11

Arg Arg Arg Arg Arg Arg 
1               5       


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  12

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  13
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence

<400>  13

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is methionine or valine

<400>  14

Glu Ala Ser Ala Leu Val Cys Ile Arg Leu Val Thr Ser Ser Lys Pro 
1               5                   10                  15      


Arg Thr Xaa Ala 
            20  


<210>  15
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is methionine or valine

<400>  15

Lys Arg Arg Met Lys Trp Lys Lys Glu Ala Ser Ala Leu Val Cys Ile 
1               5                   10                  15      


Arg Leu Val Thr Ser Ser Lys Pro Arg Thr Xaa Ala 
            20                  25              


<210>  16
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X is methionine or valine

<400>  16

Pro Lys Lys Lys Arg Arg Val Glu Ala Ser Ala Leu Val Cys Ile Arg 
1               5                   10                  15      


Leu Val Thr Ser Ser Lys Pro Arg Thr Xaa Ala 
            20                  25          


<210>  17
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  X is methionine or valine

<400>  17

His Ala Ile Tyr Pro Arg His Glu Ala Ser Ala Leu Val Cys Ile Arg 
1               5                   10                  15      


Leu Val Thr Ser Ser Lys Pro Arg Thr Xaa Ala 
            20                  25          


<210>  18
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  X is methionine or valine

<400>  18

His Ala Ile Tyr Pro Arg His Lys Lys Lys Arg Lys Glu Ala Ser Ala 
1               5                   10                  15      


Leu Val Cys Ile Arg Leu Val Thr Ser Ser Lys Pro Arg Thr Xaa Ala 
            20                  25                  30          


<210>  19
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X is methionine or valine

<400>  19

Arg Arg Arg Arg Arg Arg Arg Arg Arg Lys Lys Lys Arg Lys Glu Ala 
1               5                   10                  15      


Ser Ala Leu Val Cys Ile Arg Leu Val Thr Ser Ser Lys Pro Arg Thr 
            20                  25                  30          


Xaa Ala 
        


<210>  20
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  X is methionine or valine

<400>  20

Lys Arg Arg Met Lys Trp Lys Lys Lys Arg Lys Glu Ala Ser Ala Leu 
1               5                   10                  15      


Val Cys Ile Arg Leu Val Thr Ser Ser Lys Pro Arg Thr Xaa Ala 
            20                  25                  30      


<210>  21
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is methionine or valine

<400>  21

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Ile Lys Lys Lys Arg 
1               5                   10                  15      


Lys Trp Val Thr Ser Ser Lys Pro Arg Thr Xaa Ala 
            20                  25              


<210>  22
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is methionine or valine

<400>  22

Glu Ala Ser Ala Leu Val Cys Ile Arg Leu Val Thr Ser Ser Lys Pro 
1               5                   10                  15      


Arg Thr Xaa Ala Trp Lys Lys Lys Arg Lys Ile Arg Arg Arg Arg Arg 
            20                  25                  30          


Arg Arg Arg Arg Arg Arg 
        35              


<210>  23
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  X is methionine or valine

<400>  23

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Ile Lys Lys Lys Arg 
1               5                   10                  15      


Lys Trp Glu Ala Ser Ala Leu Val Cys Ile Arg Leu Val Thr Ser Ser 
            20                  25                  30          


Lys Pro Arg Thr Xaa Ala 
        35              


<210>  24
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  X is methionine or valine

<400>  24

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Ile Lys Lys Lys Arg 
1               5                   10                  15      


Lys Trp Val Thr Ser Ser Lys Pro Arg Thr Xaa Ala 
            20                  25              


<210>  25
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  X is methionine or valine

<400>  25

His Ala Ile Tyr Pro Arg His His Ala Ile Tyr Pro Arg His Glu Ala 
1               5                   10                  15      


Ser Ala Leu Val Cys Ile Arg Leu Val Thr Ser Ser Lys Pro Arg Thr 
            20                  25                  30          


Xaa Ala 
        


<210>  26
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  26

Met Asp Arg Trp Leu Val Lys Trp Lys Lys Lys Arg Lys Ile Arg Arg 
1               5                   10                  15      


Arg Arg Arg Arg Arg Arg Arg Arg Arg 
            20                  25  


<210>  27
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  27

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Ile Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val Thr Ser Ser Lys Pro Arg Thr Val Ala Trp Thr Ser Arg Phe 
            20                  25                  30          


Thr Ile Trp Ala Asp 
        35          


<210>  28
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  28

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Ile Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val Thr Ser Ser Lys Pro Arg Thr Val Ala Trp Thr Ser Arg Phe 
            20                  25                  30          


Thr Ile Trp Ala Asp 
        35          


<210>  29
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  29

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Ile Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val Thr Ser Ser Lys Pro Arg Thr Ala Ala Ala Thr Ser Arg Phe 
            20                  25                  30          


Thr Ile Trp Ala Asp 
        35          


<210>  30
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  30

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Ile Lys Lys Lys Arg 
1               5                   10                  15      


Lys Trp Val Cys Ile Arg Leu Val Thr Ser Ser Lys Pro Arg Thr Val 
            20                  25                  30          


Ala Trp Thr Ser Arg Phe 
        35              


<210>  31
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  31

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Ile Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val Thr Ser Ser Lys Pro Arg Thr Ala Ala Trp Thr Ser Arg Phe 
            20                  25                  30          


Thr Ile Trp Ala Asp 
        35          


<210>  32
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence

<400>  32

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Ile Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val Thr Ser Ser Lys Pro Arg Thr Trp Ala Ala Thr Ser Arg Phe 
            20                  25                  30          


Thr Ile Trp Ala Asp 
        35          


<210>  33
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic sequence


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<400>  33

Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Arg Ile Lys Lys Lys Arg 
1               5                   10                  15      


Lys Trp Val Thr Ser Ser Lys Pro Arg Thr Xaa Ala Trp Thr Ser Arg 
            20                  25                  30          


Phe Thr Ile Trp Ala Ala 
        35              


<210>  34
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Met Ala Trp Arg Ala Leu His Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Phe Pro Gly Ser Gln Ala Gln Ser Lys Ala Gln Val Leu Gln Ser Val 
            20                  25                  30          


Ala Gly Gln Thr Leu Thr Val Arg Cys Gln Tyr Pro Pro Thr Gly Ser 
        35                  40                  45              


Leu Tyr Glu Lys Lys Gly Trp Cys Lys Glu Ala Ser Ala Leu Val Cys 
    50                  55                  60                  


Ile Arg Leu Val Thr Ser Ser Lys Pro Arg Thr Met Ala Trp Thr Ser 
65                  70                  75                  80  


Arg Phe Thr Ile Trp Asp Asp Pro Asp Ala Gly Phe Phe Thr Val Thr 
                85                  90                  95      


Met Thr Asp Leu Arg Glu Glu Asp Ser Gly His Tyr Trp Cys Arg Ile 
            100                 105                 110         


Tyr Arg Pro Ser Asp Asn Ser Val Ser Lys Ser Val Arg Phe Tyr Leu 
        115                 120                 125             


Val Val Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg 
    130                 135                 140                 


Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr 
145                 150                 155                 160 


Ala Gly Ala Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro 
                165                 170                 175     


Ser His Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln 
            180                 185                 190         


Asn Ser Thr Leu Arg Pro Gly Pro Ala Ala Pro Ile Ala Leu Val Pro 
        195                 200                 205             


Val Phe Cys Gly Leu Leu Val Ala Lys Ser Leu Val Leu Ser Ala Leu 
    210                 215                 220                 


Leu Val Trp Trp Val Leu Arg Asn Arg His Met Gln His Gln Gly Arg 
225                 230                 235                 240 


Ser Leu Leu His Pro Ala Gln Pro Arg Pro Gln Ala His Arg His Phe 
                245                 250                 255     


Pro Leu Ser His Arg Ala Pro Gly Gly Thr Tyr Gly Gly Lys Pro 
            260                 265                 270     


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  35

Val Thr Ser Ser Lys Pro Arg Thr Val Ala 
1               5                   10  


<210>  36
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  36

Tyr Pro Pro Thr Gly Ser Leu Tyr Glu Lys Lys Gly Trp Cys Lys Glu 
1               5                   10                  15      


Ala Ser Ala Leu 
            20  


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  37

Val Thr Ser Ser Lys Pro Arg Thr Met Ala 
1               5                   10  


<210>  38
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  38

Val Thr Ser Ser Lys Pro Arg Thr Ala Ala Ala Thr Ser Arg Phe Thr 
1               5                   10                  15      


Ile Trp Ala Asp 
            20  


<210>  39
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  39

Val Thr Ser Ser Lys Pro Arg Thr Ala Ala Ala Thr Ser Arg Phe Thr 
1               5                   10                  15      


Ile Trp Asp Asp 
            20  


<210>  40
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  40

Val Thr Ser Ser Lys Pro Arg Thr Ala Ala Ala Thr Ser Arg Phe Thr 
1               5                   10                  15      


Ile Trp Ala Ala 
            20  


<210>  41
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  41

Val Thr Ser Ser Lys Pro Arg Thr Ala Ala Ala Thr Ser Arg Phe Thr 
1               5                   10                  15      


Ile Trp Asp Ala 
            20  


<210>  42
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42

Val Cys Ile Arg Leu Val Thr Ser Ser Lys Pro Arg Thr Val Ala Trp 
1               5                   10                  15      


Thr Ser Arg Phe 
            20  


<210>  43
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  43

Val Cys Ile Arg Leu Val Thr Ser Ser Lys Pro Arg Thr Met Ala Trp 
1               5                   10                  15      


Thr Ser Arg Phe 
            20  


