                         SEQUENCE LISTING

<110>  NewSouth Innovations Pty Limited
 
<120>  Methods for enhancing vascular density

<130>  P104743.PCT

<150>  2016905310
<151>  2016-12-21

<160>  51    

<170>  PatentIn version 3.5

<210>  1
<211>  1668
<212>  DNA
<213>  Human

<400>  1
atgattggca cagatcctcg aacaattctt aaagatttat tgccggaaac aatacctcca       60

cctgagttgg atgatatgac actgtggcag attgttatta atatcctttc agaaccacca      120

aaaaggaaaa aaagaaaaga tattaataca attgaagatg ctgtgaaatt actgcaagag      180

tgcaaaaaaa ttatagttct aactggagct ggggtgtctg tttcatgtgg aatacctgac      240

ttcaggtcaa gggatggtat ttatgctcgc cttgctgtag acttcccaga tcttccagat      300

cctcaagcga tgtttgatat tgaatatttc agaaaagatc caagaccatt cttcaagttt      360

gcaaaggaaa tatatcctgg acaattccag ccatctctct gtcacaaatt catagccttg      420

tcagataagg aaggaaaact acttcgcaac tatacccaga acatagacac gctggaacag      480

gttgcgggaa tccaaaggat aattcagtgt catggttcct ttgcaacagc atcttgcctg      540

atttgtaaat acaaagttga ctgtgaagct gtacgaggag ctctttttag tcaggtagtt      600

cctcgatgtc ctaggtgccc agctgatgaa ccgcttgcta tcatgaaacc agagattgtg      660

ttttttggtg aaaatttacc agaacagttt catagagcca tgaagtatga caaagatgaa      720

gttgacctcc tcattgttat tgggtcttcc ctcaaagtaa gaccagtagc actaattcca      780

agttccatac cccatgaagt gcctcagata ttaattaata gagaaccttt gcctcatctg      840

cattttgatg tagagcttct tggagactgt gatgtcataa ttaatgaatt gtgtcatagg      900

ttaggtggtg aatatgccaa actttgctgt aaccctgtaa agctttcaga aattactgaa      960

aaacctccac gaacacaaaa agaattggct tatttgtcag agttgccacc cacacctctt     1020

catgtttcag aagactcaag ttcaccagaa agaacttcac caccagattc ttcagtgatt     1080

gtcacacttt tagaccaagc agctaagagt aatgatgatt tagatgtgtc tgaatcaaaa     1140

ggttgtatgg aagaaaaacc acaggaagta caaacttcta ggaatgttga aagtattgct     1200

gaacagatgg aaaatccgga tttgaagaat gttggttcta gtactgggga gaaaaatgaa     1260

agaacttcag tggctggaac agtgagaaaa tgctggccta atagagtggc aaaggagcag     1320

attagtaggc ggcttgatgg taatcagtat ctgtttttgc caccaaatcg ttacattttc     1380

catggcgctg aggtatattc agactctgaa gatgacgtct tatcctctag ttcttgtggc     1440

agtaacagtg atagtgggac atgccagagt ccaagtttag aagaacccat ggaggatgaa     1500

agtgaaattg aagaattcta caatggctta gaagatgagc ctgatgttcc agagagagct     1560

ggaggagctg gatttgggac tgatggagat gatcaagagg caattaatga agctatatct     1620

gtgaaacagg aagtaacaga catgaactat ccatcaaaca aatcatag                  1668


<210>  2
<211>  555
<212>  PRT
<213>  Human

<400>  2

Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 
1               5                   10                  15      


Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 
            20                  25                  30          


Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 
        35                  40                  45              


Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 
    50                  55                  60                  


Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 
65                  70                  75                  80  


Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Val Asp Phe Pro 
                85                  90                  95      


Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 
            100                 105                 110         


Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 
        115                 120                 125             


Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 
    130                 135                 140                 


Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 
145                 150                 155                 160 


Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 
                165                 170                 175     


Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 
            180                 185                 190         


Gly Ala Leu Phe Ser Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 
        195                 200                 205             


Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 
    210                 215                 220                 


Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 
225                 230                 235                 240 


Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 
                245                 250                 255     


Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 
            260                 265                 270         


Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 
        275                 280                 285             


Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 
    290                 295                 300                 


Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 
305                 310                 315                 320 


Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala Tyr Leu Ser Glu Leu Pro 
                325                 330                 335     


Pro Thr Pro Leu His Val Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 
            340                 345                 350         


Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Ala 
        355                 360                 365             


Lys Ser Asn Asp Asp Leu Asp Val Ser Glu Ser Lys Gly Cys Met Glu 
    370                 375                 380                 


Glu Lys Pro Gln Glu Val Gln Thr Ser Arg Asn Val Glu Ser Ile Ala 
385                 390                 395                 400 


Glu Gln Met Glu Asn Pro Asp Leu Lys Asn Val Gly Ser Ser Thr Gly 
                405                 410                 415     


Glu Lys Asn Glu Arg Thr Ser Val Ala Gly Thr Val Arg Lys Cys Trp 
            420                 425                 430         


Pro Asn Arg Val Ala Lys Glu Gln Ile Ser Arg Arg Leu Asp Gly Asn 
        435                 440                 445             


Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu 
    450                 455                 460                 


Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly 
465                 470                 475                 480 


Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu Pro 
                485                 490                 495     


Met Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp 
            500                 505                 510         


Glu Pro Asp Val Pro Glu Arg Ala Gly Gly Ala Gly Phe Gly Thr Asp 
        515                 520                 525             


Gly Asp Asp Gln Glu Ala Ile Asn Glu Ala Ile Ser Val Lys Gln Glu 
    530                 535                 540                 


Val Thr Asp Met Asn Tyr Pro Ser Asn Lys Ser 
545                 550                 555 


<210>  3
<211>  576
<212>  PRT
<213>  mouse

<400>  3

Met Ala Ala Ala Ala Ala Ala Ala Ala Ile Gly Tyr Arg Gly Pro Tyr 
1               5                   10                  15      


Thr Phe Val Gln Gln His Leu Met Ile Gly Thr Asp Pro Arg Thr Ile 
            20                  25                  30          


Leu Lys Asp Leu Leu Pro Glu Thr Ile Pro Pro Pro Glu Leu Asp Asp 
        35                  40                  45              


Met Thr Leu Trp Gln Ile Val Ile Asn Ile Leu Ser Glu Pro Pro Lys 
    50                  55                  60                  


Arg Lys Lys Arg Lys Asp Ile Asn Thr Ile Glu Asp Ala Val Lys Leu 
65                  70                  75                  80  


Leu Gln Glu Cys Lys Lys Ile Ile Val Leu Thr Gly Ala Gly Val Ser 
                85                  90                  95      


Val Ser Cys Gly Ile Pro Asp Phe Arg Ser Arg Asp Gly Ile Tyr Ala 
            100                 105                 110         


Arg Leu Ala Val Asp Phe Pro Asp Leu Pro Asp Pro Gln Ala Met Phe 
        115                 120                 125             


Asp Ile Glu Tyr Phe Arg Lys Asp Pro Arg Pro Phe Phe Lys Phe Ala 
    130                 135                 140                 


Lys Glu Ile Tyr Pro Gly Gln Phe Gln Pro Ser Leu Cys His Lys Phe 
145                 150                 155                 160 


Ile Ala Leu Ser Asp Lys Glu Gly Lys Leu Leu Arg Asn Tyr Thr Gln 
                165                 170                 175     


Asn Ile Asp Thr Leu Glu Gln Val Ala Gly Ile Gln Arg Ile Leu Gln 
            180                 185                 190         


Cys His Gly Ser Phe Ala Thr Ala Ser Cys Leu Ile Cys Lys Tyr Lys 
        195                 200                 205             


Val Asp Cys Glu Ala Val Arg Gly Asp Ile Phe Asn Gln Val Val Pro 
    210                 215                 220                 


Arg Cys Pro Arg Cys Pro Ala Asp Glu Pro Leu Ala Ile Met Lys Pro 
225                 230                 235                 240 


Glu Ile Val Phe Phe Gly Glu Asn Leu Pro Glu Gln Phe His Arg Ala 
                245                 250                 255     


Met Lys Tyr Asp Lys Asp Glu Val Asp Leu Leu Ile Val Ile Gly Ser 
            260                 265                 270         


Ser Leu Lys Val Arg Pro Val Ala Leu Ile Pro Ser Ser Ile Pro His 
        275                 280                 285             


Glu Val Pro Gln Ile Leu Ile Asn Arg Glu Pro Leu Pro His Leu His 
    290                 295                 300                 


Phe Asp Val Glu Leu Leu Gly Asp Cys Asp Val Ile Ile Asn Glu Leu 
305                 310                 315                 320 


Cys His Arg Leu Gly Gly Glu Tyr Ala Lys Leu Cys Cys Asn Pro Val 
                325                 330                 335     


Lys Leu Ser Glu Ile Thr Glu Lys Pro Pro Arg Pro Gln Lys Glu Leu 
            340                 345                 350         


Val His Leu Ser Glu Leu Pro Pro Thr Pro Leu His Ile Ser Glu Asp 
        355                 360                 365             


Ser Ser Ser Pro Glu Arg Thr Val Pro Gln Asp Ser Ser Val Ile Ala 
    370                 375                 380                 


Thr Leu Val Asp Gln Ala Thr Asn Asn Asn Val Asn Asp Leu Glu Val 
385                 390                 395                 400 


Ser Glu Ser Ser Cys Val Glu Glu Lys Pro Gln Glu Val Gln Thr Ser 
                405                 410                 415     


Arg Asn Val Glu Asn Ile Asn Val Glu Asn Pro Asp Phe Lys Ala Val 
            420                 425                 430         


Gly Ser Ser Thr Ala Asp Lys Asn Glu Arg Thr Ser Val Ala Glu Thr 
        435                 440                 445             


Val Arg Lys Cys Trp Pro Asn Arg Leu Ala Lys Glu Gln Ile Ser Lys 
    450                 455                 460                 


Arg Leu Glu Gly Asn Gln Tyr Leu Phe Val Pro Pro Asn Arg Tyr Ile 
465                 470                 475                 480 


Phe His Gly Ala Glu Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser 
                485                 490                 495     


Ser Ser Ser Cys Gly Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro 
            500                 505                 510         


Ser Leu Glu Glu Pro Leu Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr 
        515                 520                 525             


Asn Gly Leu Glu Asp Asp Thr Glu Arg Pro Glu Cys Ala Gly Gly Ser 
    530                 535                 540                 


Gly Phe Gly Ala Asp Gly Gly Asp Gln Glu Val Val Asn Glu Ala Ile 
545                 550                 555                 560 


Ala Thr Arg Gln Glu Leu Thr Asp Val Asn Tyr Pro Ser Asp Lys Ser 
                565                 570                 575     


<210>  4
<211>  746
<212>  PRT
<213>  cat

<400>  4

Met Ala Asp Glu Ala Ala Leu Ala Leu Gln Pro Gly Gly Ser Pro Ser 
1               5                   10                  15      


Ala Val Val Ala Glu Arg Glu Ala Ala Ser Pro Pro Ala Gly Glu Pro 
            20                  25                  30          


Leu Arg Lys Arg Pro Arg Arg Asp Cys Pro Gly Leu Gly Arg Ser Pro 
        35                  40                  45              


Gly Glu Pro Gly Gly Ala Ala Pro Glu Arg Glu Val Pro Ala Ala Thr 
    50                  55                  60                  


Gly Gly Cys Pro Ala Ala Ala Ala Ala Leu Trp Arg Glu Ala Ala Ala 
65                  70                  75                  80  


Ala Gly Glu Glu Arg Glu Ala Gln Ala Ala Thr Ala Gly Glu Gly Asp 
                85                  90                  95      


Asn Gly Pro Gly Leu Gln Gly Leu Thr Arg Glu Pro Pro Pro Ala Asp 
            100                 105                 110         


Asp Phe Tyr Asp Asp Asp Asp Asp Asp Asp Asp Glu Gly Glu Glu Glu 
        115                 120                 125             


Glu Glu Ala Ala Ala Ala Ala Ala Ile Gly Tyr Arg Asp Asn Leu Leu 
    130                 135                 140                 


Phe Gly Asp Glu Ile Ile Thr Asn Gly Phe His Ser Cys Glu Ser Asp 
145                 150                 155                 160 


Glu Asp Asp Arg Ala Ser His Ala Ser Ser Ser Asp Trp Thr Pro Arg 
                165                 170                 175     


Pro Arg Ile Gly Pro Tyr Thr Phe Val Gln Gln His Leu Met Ile Gly 
            180                 185                 190         


Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu Thr Ile Pro 
        195                 200                 205             


Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val Ile Asn Ile 
    210                 215                 220                 


Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile Asn Thr Ile 
225                 230                 235                 240 


Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile Ile Val Leu 
                245                 250                 255     


Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp Phe Arg Ser 
            260                 265                 270         


Arg Asp Gly Ile Tyr Ala Arg Leu Ala Ile Asp Phe Pro Asp Leu Pro 
        275                 280                 285             


Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys Asp Pro Arg 
    290                 295                 300                 


Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln Phe Gln Pro 
305                 310                 315                 320 


Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu Gly Lys Leu 
                325                 330                 335     


Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln Val Ala Gly 
            340                 345                 350         


Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr Ala Ser Cys 
        355                 360                 365             


Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg Gly Asp Ile 
    370                 375                 380                 


Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala Asp Glu Pro 
385                 390                 395                 400 


Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu Asn Leu Pro 
                405                 410                 415     


Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu Val Asp Leu 
            420                 425                 430         


Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val Ala Leu Ile 
        435                 440                 445             


Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile Asn Arg Glu 
    450                 455                 460                 


Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly Asp Cys Asp 
465                 470                 475                 480 


Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu Tyr Ala Lys 
                485                 490                 495     


Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu Lys Pro Pro 
            500                 505                 510         


Arg Thr Gln Lys Glu Leu Ala His Leu Ser Glu Leu Pro Pro Thr Pro 
        515                 520                 525             


Leu Asn Ile Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr Ser Pro Pro 
    530                 535                 540                 


Asp Ser Ser Val Ile Val Thr Leu Leu Asp Gln Ala Thr Lys Ser Asn 
545                 550                 555                 560 


Val Asn Asp Pro Glu Val Ser Glu Pro Arg Asp His Met Glu Glu Lys 
                565                 570                 575     


Ser Gln Glu Gly Gln Asn Ser Thr Arg Asn Ile Glu Ser Val Thr Glu 
            580                 585                 590         


Gln Leu Gly Ser Pro Asp Ser Lys Asn Val Asp Ser Asn Thr Gly Glu 
        595                 600                 605             


Lys Asn Glu Arg Thr Ser Ile Ala Glu Thr Val Arg Lys Cys Trp Pro 
    610                 615                 620                 


Ala Arg Leu Ala Lys Glu Gln Ile Ser Lys Arg Leu Asp Gly Asn Gln 
625                 630                 635                 640 


Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly Ala Glu Val 
                645                 650                 655     


Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser Cys Gly Ser 
            660                 665                 670         


Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu Glu His Leu 
        675                 680                 685             


Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu Glu Asp Asp 
    690                 695                 700                 


Ala Asp Val Asn Glu Arg Ala Gly Gly Thr Gly Phe Gly Val Asp Gly 
705                 710                 715                 720 


Gly Asp Gln Glu Ala Val Asn Glu Ala Ile Ser Val Lys Gln Glu Ala 
                725                 730                 735     


Thr Asp Ile Asn Tyr Pro Ser Asn Lys Ser 
            740                 745     


<210>  5
<211>  557
<212>  PRT
<213>  dog

<400>  5

Met Ile Gly Thr Asp Pro Arg Thr Ile Leu Lys Asp Leu Leu Pro Glu 
1               5                   10                  15      


Thr Ile Pro Pro Pro Glu Leu Asp Asp Met Thr Leu Trp Gln Ile Val 
            20                  25                  30          


Ile Asn Ile Leu Ser Glu Pro Pro Lys Arg Lys Lys Arg Lys Asp Ile 
        35                  40                  45              


Asn Thr Ile Glu Asp Ala Val Lys Leu Leu Gln Glu Cys Lys Lys Ile 
    50                  55                  60                  


Ile Val Leu Thr Gly Ala Gly Val Ser Val Ser Cys Gly Ile Pro Asp 
65                  70                  75                  80  


Phe Arg Ser Arg Asp Gly Ile Tyr Ala Arg Leu Ala Ile Asp Phe Pro 
                85                  90                  95      


Asp Leu Pro Asp Pro Gln Ala Met Phe Asp Ile Glu Tyr Phe Arg Lys 
            100                 105                 110         


Asp Pro Arg Pro Phe Phe Lys Phe Ala Lys Glu Ile Tyr Pro Gly Gln 
        115                 120                 125             


Phe Gln Pro Ser Leu Cys His Lys Phe Ile Ala Leu Ser Asp Lys Glu 
    130                 135                 140                 


Gly Lys Leu Leu Arg Asn Tyr Thr Gln Asn Ile Asp Thr Leu Glu Gln 
145                 150                 155                 160 


Val Ala Gly Ile Gln Arg Ile Ile Gln Cys His Gly Ser Phe Ala Thr 
                165                 170                 175     


Ala Ser Cys Leu Ile Cys Lys Tyr Lys Val Asp Cys Glu Ala Val Arg 
            180                 185                 190         


Gly Asp Ile Phe Asn Gln Val Val Pro Arg Cys Pro Arg Cys Pro Ala 
        195                 200                 205             


Asp Glu Pro Leu Ala Ile Met Lys Pro Glu Ile Val Phe Phe Gly Glu 
    210                 215                 220                 


Asn Leu Pro Glu Gln Phe His Arg Ala Met Lys Tyr Asp Lys Asp Glu 
225                 230                 235                 240 


Val Asp Leu Leu Ile Val Ile Gly Ser Ser Leu Lys Val Arg Pro Val 
                245                 250                 255     


Ala Leu Ile Pro Ser Ser Ile Pro His Glu Val Pro Gln Ile Leu Ile 
            260                 265                 270         


Asn Arg Glu Pro Leu Pro His Leu His Phe Asp Val Glu Leu Leu Gly 
        275                 280                 285             


Asp Cys Asp Val Ile Ile Asn Glu Leu Cys His Arg Leu Gly Gly Glu 
    290                 295                 300                 


Tyr Ala Lys Leu Cys Cys Asn Pro Val Lys Leu Ser Glu Ile Thr Glu 
305                 310                 315                 320 


Lys Pro Pro Arg Thr Gln Lys Glu Leu Ala His Leu Ser Glu Leu Pro 
                325                 330                 335     


Pro Thr Pro Leu Asn Ile Ser Glu Asp Ser Ser Ser Pro Glu Arg Thr 
            340                 345                 350         


Ser Pro Pro Asp Ser Ser Val Ile Val Thr Leu Leu Asp Glu Ala Thr 
        355                 360                 365             


Lys Ser Asn Val Asp Asp Pro Gly Val Ser Glu Ser Arg Asp Cys Met 
    370                 375                 380                 


Glu Glu Lys Ser Gln Glu Gly Gln Asn Ser Ile Arg Asn Ile Glu Ser 
385                 390                 395                 400 


Val Thr Glu His Leu Glu Ser Pro Asp Leu Lys Asn Val Gly Cys Asn 
                405                 410                 415     


Thr Gly Glu Lys Asn Glu Arg Thr Ser Val Ala Asp Pro Val Arg Lys 
            420                 425                 430         


Cys Trp Pro Ala Arg Leu Ala Lys Glu Gln Ile Ser Lys Arg Leu Asp 
        435                 440                 445             


Gly Asn Gln Tyr Leu Phe Leu Pro Pro Asn Arg Tyr Ile Phe His Gly 
    450                 455                 460                 


Ala Glu Val Tyr Ser Asp Ser Glu Asp Asp Val Leu Ser Ser Ser Ser 
465                 470                 475                 480 


Cys Gly Ser Asn Ser Asp Ser Gly Thr Cys Gln Ser Pro Ser Leu Glu 
                485                 490                 495     


Glu His Leu Glu Asp Glu Ser Glu Ile Glu Glu Phe Tyr Asn Gly Leu 
            500                 505                 510         


Glu Asp Glu Ala Asp Val Asn Glu Arg Ala Gly Gly Thr Gly Phe Gly 
        515                 520                 525             


Ile Asp Gly Gly Asp Gln Glu Ala Val Asn Glu Ala Ile Ser Met Lys 
    530                 535                 540                 


Gln Glu Ala Thr Asp Thr Asn Tyr Pro Ser Asn Lys Ser 
545                 550                 555         


<210>  6
<211>  491
<212>  PRT
<213>  human

<400>  6

Met Asn Pro Ala Ala Glu Ala Glu Phe Asn Ile Leu Leu Ala Thr Asp 
1               5                   10                  15      


Ser Tyr Lys Val Thr His Tyr Lys Gln Tyr Pro Pro Asn Thr Ser Lys 
            20                  25                  30          


Val Tyr Ser Tyr Phe Glu Cys Arg Glu Lys Lys Thr Glu Asn Ser Lys 
        35                  40                  45              


Leu Arg Lys Val Lys Tyr Glu Glu Thr Val Phe Tyr Gly Leu Gln Tyr 
    50                  55                  60                  


Ile Leu Asn Lys Tyr Leu Lys Gly Lys Val Val Thr Lys Glu Lys Ile 
65                  70                  75                  80  


Gln Glu Ala Lys Asp Val Tyr Lys Glu His Phe Gln Asp Asp Val Phe 
                85                  90                  95      


Asn Glu Lys Gly Trp Asn Tyr Ile Leu Glu Lys Tyr Asp Gly His Leu 
            100                 105                 110         


Pro Ile Glu Ile Lys Ala Val Pro Glu Gly Phe Val Ile Pro Arg Gly 
        115                 120                 125             


Asn Val Leu Phe Thr Val Glu Asn Thr Asp Pro Glu Cys Tyr Trp Leu 
    130                 135                 140                 


Thr Asn Trp Ile Glu Thr Ile Leu Val Gln Ser Trp Tyr Pro Ile Thr 
145                 150                 155                 160 


Val Ala Thr Asn Ser Arg Glu Gln Lys Lys Ile Leu Ala Lys Tyr Leu 
                165                 170                 175     


Leu Glu Thr Ser Gly Asn Leu Asp Gly Leu Glu Tyr Lys Leu His Asp 
            180                 185                 190         


Phe Gly Tyr Arg Gly Val Ser Ser Gln Glu Thr Ala Gly Ile Gly Ala 
        195                 200                 205             


Ser Ala His Leu Val Asn Phe Lys Gly Thr Asp Thr Val Ala Gly Leu 
    210                 215                 220                 


Ala Leu Ile Lys Lys Tyr Tyr Gly Thr Lys Asp Pro Val Pro Gly Tyr 
225                 230                 235                 240 


Ser Val Pro Ala Ala Glu His Ser Thr Ile Thr Ala Trp Gly Lys Asp 
                245                 250                 255     


His Glu Lys Asp Ala Phe Glu His Ile Val Thr Gln Phe Ser Ser Val 
            260                 265                 270         


Pro Val Ser Val Val Ser Asp Ser Tyr Asp Ile Tyr Asn Ala Cys Glu 
        275                 280                 285             


Lys Ile Trp Gly Glu Asp Leu Arg His Leu Ile Val Ser Arg Ser Thr 
    290                 295                 300                 


Gln Ala Pro Leu Ile Ile Arg Pro Asp Ser Gly Asn Pro Leu Asp Thr 
305                 310                 315                 320 


Val Leu Lys Val Leu Glu Ile Leu Gly Lys Lys Phe Pro Val Thr Glu 
                325                 330                 335     


Asn Ser Lys Gly Tyr Lys Leu Leu Pro Pro Tyr Leu Arg Val Ile Gln 
            340                 345                 350         


Gly Asp Gly Val Asp Ile Asn Thr Leu Gln Glu Ile Val Glu Gly Met 
        355                 360                 365             


Lys Gln Lys Met Trp Ser Ile Glu Asn Ile Ala Phe Gly Ser Gly Gly 
    370                 375                 380                 


Gly Leu Leu Gln Lys Leu Thr Arg Asp Leu Leu Asn Cys Ser Phe Lys 
385                 390                 395                 400 


Cys Ser Tyr Val Val Thr Asn Gly Leu Gly Ile Asn Val Phe Lys Asp 
                405                 410                 415     


Pro Val Ala Asp Pro Asn Lys Arg Ser Lys Lys Gly Arg Leu Ser Leu 
            420                 425                 430         


His Arg Thr Pro Ala Gly Asn Phe Val Thr Leu Glu Glu Gly Lys Gly 
        435                 440                 445             


Asp Leu Glu Glu Tyr Gly Gln Asp Leu Leu His Thr Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Val Thr Lys Ser Tyr Ser Phe Asp Glu Ile Arg Lys Asn Ala 
465                 470                 475                 480 


Gln Leu Asn Ile Glu Leu Glu Ala Ala His His 
                485                 490     


<210>  7
<211>  491
<212>  PRT
<213>  mouse

<400>  7

Met Asn Ala Ala Ala Glu Ala Glu Phe Asn Ile Leu Leu Ala Thr Asp 
1               5                   10                  15      


Ser Tyr Lys Val Thr His Tyr Lys Gln Tyr Pro Pro Asn Thr Ser Lys 
            20                  25                  30          


Val Tyr Ser Tyr Phe Glu Cys Arg Glu Lys Lys Thr Glu Asn Ser Lys 
        35                  40                  45              


Val Arg Lys Val Lys Tyr Glu Glu Thr Val Phe Tyr Gly Leu Gln Tyr 
    50                  55                  60                  


Ile Leu Asn Lys Tyr Leu Lys Gly Lys Val Val Thr Lys Glu Lys Ile 
65                  70                  75                  80  


Gln Glu Ala Lys Glu Val Tyr Arg Glu His Phe Gln Asp Asp Val Phe 
                85                  90                  95      


Asn Glu Arg Gly Trp Asn Tyr Ile Leu Glu Lys Tyr Asp Gly His Leu 
            100                 105                 110         


Pro Ile Glu Val Lys Ala Val Pro Glu Gly Ser Val Ile Pro Arg Gly 
        115                 120                 125             


Asn Val Leu Phe Thr Val Glu Asn Thr Asp Pro Glu Cys Tyr Trp Leu 
    130                 135                 140                 


Thr Asn Trp Ile Glu Thr Ile Leu Val Gln Ser Trp Tyr Pro Ile Thr 
145                 150                 155                 160 


Val Ala Thr Asn Ser Arg Glu Gln Lys Lys Ile Leu Ala Lys Tyr Leu 
                165                 170                 175     


Leu Glu Thr Ser Gly Asn Leu Asp Gly Leu Glu Tyr Lys Leu His Asp 
            180                 185                 190         


Phe Gly Tyr Arg Gly Val Ser Ser Gln Glu Thr Ala Gly Ile Gly Ala 
        195                 200                 205             


Ser Ala His Leu Val Asn Phe Lys Gly Thr Asp Thr Val Ala Gly Ile 
    210                 215                 220                 


Ala Leu Ile Lys Lys Tyr Tyr Gly Thr Lys Asp Pro Val Pro Gly Tyr 
225                 230                 235                 240 


Ser Val Pro Ala Ala Glu His Ser Thr Ile Thr Ala Trp Gly Lys Asp 
                245                 250                 255     


His Glu Lys Asp Ala Phe Glu His Ile Val Thr Gln Phe Ser Ser Val 
            260                 265                 270         


Pro Val Ser Val Val Ser Asp Ser Tyr Asp Ile Tyr Asn Ala Cys Glu 
        275                 280                 285             


Lys Ile Trp Gly Glu Asp Leu Arg His Leu Ile Val Ser Arg Ser Thr 
    290                 295                 300                 


Glu Ala Pro Leu Ile Ile Arg Pro Asp Ser Gly Asn Pro Leu Asp Thr 
305                 310                 315                 320 


Val Leu Lys Val Leu Asp Ile Leu Gly Lys Lys Phe Pro Val Thr Glu 
                325                 330                 335     


Asn Ser Lys Gly Tyr Lys Leu Leu Pro Pro Tyr Leu Arg Val Ile Gln 
            340                 345                 350         


Gly Asp Gly Val Asp Ile Asn Thr Leu Gln Glu Ile Val Glu Gly Met 
        355                 360                 365             


Lys Gln Lys Lys Trp Ser Ile Glu Asn Val Ser Phe Gly Ser Gly Gly 
    370                 375                 380                 


Ala Leu Leu Gln Lys Leu Thr Arg Asp Leu Leu Asn Cys Ser Phe Lys 
385                 390                 395                 400 


Cys Ser Tyr Val Val Thr Asn Gly Leu Gly Val Asn Val Phe Lys Asp 
                405                 410                 415     


Pro Val Ala Asp Pro Asn Lys Arg Ser Lys Lys Gly Arg Leu Ser Leu 
            420                 425                 430         


His Arg Thr Pro Ala Gly Asn Phe Val Thr Leu Glu Glu Gly Lys Gly 
        435                 440                 445             


Asp Leu Glu Glu Tyr Gly His Asp Leu Leu His Thr Val Phe Lys Asn 
    450                 455                 460                 


Gly Lys Val Thr Lys Ser Tyr Ser Phe Asp Glu Val Arg Lys Asn Ala 
465                 470                 475                 480 


Gln Leu Asn Ile Glu Gln Asp Val Ala Pro His 
                485                 490     


<210>  8
<211>  529
<212>  PRT
<213>  dog

<400>  8

Met Thr Asp Ser Gly Cys Pro Ala Pro Arg Gln Pro Ser Ala Arg Gly 
1               5                   10                  15      


Arg Arg Pro Arg Arg Ala Pro Gly Cys Gly Gly Ala Arg Ser Trp Arg 
            20                  25                  30          


Asp Pro Ser Gly Pro Arg Ser Ala Pro Ala Arg Ala Ala Ala Ser Pro 
        35                  40                  45              


Gly Pro Ala Gly Ser Ser Ser Ala Gln Val Thr His Tyr Lys Gln Tyr 
    50                  55                  60                  


Pro Pro Asn Thr Ser Lys Val Tyr Ser Tyr Phe Glu Cys Arg Glu Lys 
65                  70                  75                  80  


Lys Thr Glu Asn Ser Lys Ile Lys Lys Val Lys Tyr Glu Glu Thr Val 
                85                  90                  95      


Phe Tyr Gly Leu Gln Tyr Ile Leu Asn Lys Tyr Leu Lys Gly Lys Val 
            100                 105                 110         


Val Thr Ala Glu Lys Ile Gln Glu Ala Lys Glu Val Tyr Arg Glu His 
        115                 120                 125             


Phe Gln Asp Asp Val Phe Asn Glu Lys Gly Trp Asn Tyr Ile Leu Glu 
    130                 135                 140                 


Lys Tyr Asp Gly His Leu Pro Ile Glu Ile Lys Ala Val Pro Glu Gly 
145                 150                 155                 160 


Tyr Val Ile Pro Arg Gly Asn Val Leu Phe Thr Val Glu Asn Thr Asp 
                165                 170                 175     


Pro Glu Cys Tyr Trp Leu Thr Asn Trp Ile Glu Thr Ile Leu Val Gln 
            180                 185                 190         


Ser Trp Tyr Pro Ile Thr Val Ala Thr Asn Ser Arg Glu Gln Lys Lys 
        195                 200                 205             


Ile Leu Ala Lys Tyr Leu Leu Glu Thr Ser Gly Asn Leu Asp Gly Leu 
    210                 215                 220                 


Glu Tyr Lys Leu His Asp Phe Gly Tyr Arg Gly Val Ser Ser Gln Glu 
225                 230                 235                 240 


Thr Ala Gly Ile Gly Ala Ser Ala His Leu Val Asn Phe Lys Gly Thr 
                245                 250                 255     


Asp Thr Val Ala Gly Ile Ala Phe Val Lys Lys Tyr Tyr Gly Thr Lys 
            260                 265                 270         


Asp Pro Val Pro Gly Tyr Ser Val Pro Ala Ala Glu His Ser Thr Ile 
        275                 280                 285             


Thr Ala Trp Gly Lys Asp Arg Glu Lys Asp Ala Phe Glu His Ile Val 
    290                 295                 300                 


Thr Gln Phe Ser Ser Val Pro Val Ser Val Val Ser Asp Ser Tyr Asp 
305                 310                 315                 320 


Ile Tyr Asn Ala Cys Glu Lys Ile Trp Gly Glu Asp Leu Arg His Leu 
                325                 330                 335     


Ile Leu Ser Arg Thr Thr Glu Ala Pro Leu Ile Ile Arg Pro Asp Ser 
            340                 345                 350         


Gly Asn Pro Leu Asp Thr Val Leu Lys Val Leu Asp Ile Leu Gly Lys 
        355                 360                 365             


Lys Phe Pro Ile Thr Glu Asn Ser Lys Gly Tyr Lys Leu Leu Pro Pro 
    370                 375                 380                 


Tyr Leu Arg Val Ile Gln Gly Asp Gly Val Asp Ile Asn Thr Leu Gln 
385                 390                 395                 400 


Glu Ile Val Glu Gly Met Lys Gln Lys Lys Trp Ser Ile Glu Asn Ile 
                405                 410                 415     


Ala Phe Gly Ser Gly Gly Ala Leu Leu Gln Lys Leu Thr Arg Asp Leu 
            420                 425                 430         


Leu Asn Cys Ser Phe Lys Cys Ser Tyr Val Val Thr Asn Gly Leu Gly 
        435                 440                 445             


Ile Asn Val Phe Lys Asp Pro Val Ala Asp Pro Asn Lys Arg Ser Lys 
    450                 455                 460                 


Lys Gly Arg Leu Ser Leu His Arg Thr Pro Ala Gly Asn Phe Val Thr 
465                 470                 475                 480 


Leu Glu Glu Gly Lys Gly Asp Leu Glu Glu Tyr Gly His Asp Leu Leu 
                485                 490                 495     


His Thr Val Phe Lys Asn Gly Lys Val Thr Lys Ser Tyr Ser Phe Asp 
            500                 505                 510         


Glu Ile Arg Lys Asn Ala Lys Leu Asn Ile Glu Leu Glu Val Ala Pro 
        515                 520                 525             


His 
    


<210>  9
<211>  279
<212>  PRT
<213>  human

<400>  9

Met Glu Asn Ser Glu Lys Thr Glu Val Val Leu Leu Ala Cys Gly Ser 
1               5                   10                  15      


Phe Asn Pro Ile Thr Asn Met His Leu Arg Leu Phe Glu Leu Ala Lys 
            20                  25                  30          


Asp Tyr Met Asn Gly Thr Gly Arg Tyr Thr Val Val Lys Gly Ile Ile 
        35                  40                  45              


Ser Pro Val Gly Asp Ala Tyr Lys Lys Lys Gly Leu Ile Pro Ala Tyr 
    50                  55                  60                  


His Arg Val Ile Met Ala Glu Leu Ala Thr Lys Asn Ser Lys Trp Val 
65                  70                  75                  80  


Glu Val Asp Thr Trp Glu Ser Leu Gln Lys Glu Trp Lys Glu Thr Leu 
                85                  90                  95      


Lys Val Leu Arg His His Gln Glu Lys Leu Glu Ala Ser Asp Cys Asp 
            100                 105                 110         


His Gln Gln Asn Ser Pro Thr Leu Glu Arg Pro Gly Arg Lys Arg Lys 
        115                 120                 125             


Trp Thr Glu Thr Gln Asp Ser Ser Gln Lys Lys Ser Leu Glu Pro Lys 
    130                 135                 140                 


Thr Lys Ala Val Pro Lys Val Lys Leu Leu Cys Gly Ala Asp Leu Leu 
145                 150                 155                 160 


Glu Ser Phe Ala Val Pro Asn Leu Trp Lys Ser Glu Asp Ile Thr Gln 
                165                 170                 175     


Ile Val Ala Asn Tyr Gly Leu Ile Cys Val Thr Arg Ala Gly Asn Asp 
            180                 185                 190         


Ala Gln Lys Phe Ile Tyr Glu Ser Asp Val Leu Trp Lys His Arg Ser 
        195                 200                 205             


Asn Ile His Val Val Asn Glu Trp Ile Ala Asn Asp Ile Ser Ser Thr 
    210                 215                 220                 


Lys Ile Arg Arg Ala Leu Arg Arg Gly Gln Ser Ile Arg Tyr Leu Val 
225                 230                 235                 240 


Pro Asp Leu Val Gln Glu Tyr Ile Glu Lys His Asn Leu Tyr Ser Ser 
                245                 250                 255     


Glu Ser Glu Asp Arg Asn Ala Gly Val Ile Leu Ala Pro Leu Gln Arg 
            260                 265                 270         


Asn Thr Ala Glu Ala Lys Thr 
        275                 


<210>  10
<211>  285
<212>  PRT
<213>  mouse

<400>  10

Met Asp Ser Ser Lys Lys Thr Glu Val Val Leu Leu Ala Cys Gly Ser 
1               5                   10                  15      


Phe Asn Pro Ile Thr Asn Met His Leu Arg Leu Phe Glu Leu Ala Lys 
            20                  25                  30          


Asp Tyr Met His Ala Thr Gly Lys Tyr Ser Val Ile Lys Gly Ile Ile 
        35                  40                  45              


Ser Pro Val Gly Asp Ala Tyr Lys Lys Lys Gly Leu Ile Pro Ala His 
    50                  55                  60                  


His Arg Ile Ile Met Ala Glu Leu Ala Thr Lys Asn Ser His Trp Val 
65                  70                  75                  80  


Glu Val Asp Thr Trp Glu Ser Leu Gln Lys Glu Trp Val Glu Thr Val 
                85                  90                  95      


Lys Val Leu Arg Tyr His Gln Glu Lys Leu Ala Thr Gly Ser Cys Ser 
            100                 105                 110         


Tyr Pro Gln Ser Ser Pro Ala Leu Glu Lys Pro Gly Arg Lys Arg Lys 
        115                 120                 125             


Trp Ala Asp Gln Lys Gln Asp Ser Ser Pro Gln Lys Pro Gln Glu Pro 
    130                 135                 140                 


Lys Pro Thr Gly Val Pro Lys Val Lys Leu Leu Cys Gly Ala Asp Leu 
145                 150                 155                 160 


Leu Glu Ser Phe Ser Val Pro Asn Leu Trp Lys Met Glu Asp Ile Thr 
                165                 170                 175     


Gln Ile Val Ala Asn Phe Gly Leu Ile Cys Ile Thr Arg Ala Gly Ser 
            180                 185                 190         


Asp Ala Gln Lys Phe Ile Tyr Glu Ser Asp Val Leu Trp Arg His Gln 
        195                 200                 205             


Ser Asn Ile His Leu Val Asn Glu Trp Ile Thr Asn Asp Ile Ser Ser 
    210                 215                 220                 


Thr Lys Ile Arg Arg Ala Leu Arg Arg Gly Gln Ser Ile Arg Tyr Leu 
225                 230                 235                 240 


Val Pro Asp Leu Val Gln Glu Tyr Ile Glu Lys His Glu Leu Tyr Asn 
                245                 250                 255     


Thr Glu Ser Glu Gly Arg Asn Ala Gly Val Thr Leu Ala Pro Leu Gln 
            260                 265                 270         


Arg Asn Ala Ala Glu Ala Lys His Asn His Ser Thr Leu 
        275                 280                 285 


<210>  11
<211>  279
<212>  PRT
<213>  dog

<400>  11

Met Glu Asn Ser Lys Met Glu Val Val Leu Leu Ala Cys Gly Ser Phe 
1               5                   10                  15      


Asn Pro Ile Thr Asn Met His Leu Arg Leu Phe Glu Leu Ala Lys Asp 
            20                  25                  30          


Tyr Met Asn Gly Thr Gly Lys Tyr Lys Val Ile Lys Gly Ile Ile Ser 
        35                  40                  45              


Pro Val Gly Asp Ala Tyr Lys Lys Lys Gly Leu Ile Ser Ala His His 
    50                  55                  60                  


Arg Val Ile Met Ala Glu Leu Ala Thr Lys Ser Ser Glu Trp Val Glu 
65                  70                  75                  80  


Val Asp Thr Trp Glu Ser Leu Gln Lys Glu Trp Val Glu Thr Ala Lys 
                85                  90                  95      


Val Leu Arg His His Gln Glu Lys Leu Glu Ala Gly Ser Cys Asp His 
            100                 105                 110         


Gln Gln Asp Ser Pro Val Arg Gly Arg Pro Gly Gln Lys Arg Lys Trp 
        115                 120                 125             


Ala Glu Gln Arg Gln Asp Phe Ser Gln Lys Lys Ser Leu Glu Pro Lys 
    130                 135                 140                 


Thr Lys Asp Val Pro Lys Val Lys Leu Leu Cys Gly Ala Asp Leu Leu 
145                 150                 155                 160 


Glu Ser Phe Gly Val Pro Asn Leu Trp Lys Ser Glu Asp Ile Thr Gln 
                165                 170                 175     


Ile Val Gly Asp Tyr Gly Leu Val Cys Ile Thr Arg Ala Gly Asn Asp 
            180                 185                 190         


Ala Gln Lys Phe Ile Tyr Glu Ser Asp Ala Leu Trp Gln His Arg Asn 
        195                 200                 205             


Asn Ile His Leu Val Asn Glu Trp Ile Thr Asn Asp Ile Ser Ser Thr 
    210                 215                 220                 


Lys Ile Arg Arg Ala Leu Arg Arg Gly Gln Ser Ile Arg Tyr Leu Val 
225                 230                 235                 240 


Pro Asp Leu Val Gln Glu Tyr Ile Glu Lys His Asp Leu Tyr Ser Cys 
                245                 250                 255     


Glu Ser Glu Glu Arg Asn Val Gly Val Ile Leu Ala Pro Leu Gln Arg 
            260                 265                 270         


Asn Thr Ala Glu Ala Asn Ser 
        275                 


<210>  12
<211>  307
<212>  PRT
<213>  human

<400>  12

Met Thr Glu Thr Thr Lys Thr His Val Ile Leu Leu Ala Cys Gly Ser 
1               5                   10                  15      


Phe Asn Pro Ile Thr Lys Gly His Ile Gln Met Phe Glu Arg Ala Arg 
            20                  25                  30          


Asp Tyr Leu His Lys Thr Gly Arg Phe Ile Val Ile Gly Gly Ile Val 
        35                  40                  45              


Ser Pro Val His Asp Ser Tyr Gly Lys Gln Gly Leu Val Ser Ser Arg 
    50                  55                  60                  


His Arg Leu Ile Met Cys Gln Leu Ala Val Gln Asn Ser Asp Trp Ile 
65                  70                  75                  80  


Arg Val Asp Pro Trp Glu Cys Tyr Gln Asp Thr Trp Gln Thr Thr Cys 
                85                  90                  95      


Ser Val Leu Glu His His Arg Asp Leu Met Lys Arg Val Thr Gly Cys 
            100                 105                 110         


Ile Leu Ser Asn Val Asn Thr Pro Ser Met Thr Pro Val Ile Gly Gln 
        115                 120                 125             


Pro Gln Asn Glu Thr Pro Gln Pro Ile Tyr Gln Asn Ser Asn Val Ala 
    130                 135                 140                 


Thr Lys Pro Thr Ala Ala Lys Ile Leu Gly Lys Val Gly Glu Ser Leu 
145                 150                 155                 160 


Ser Arg Ile Cys Cys Val Arg Pro Pro Val Glu Arg Phe Thr Phe Val 
                165                 170                 175     


Asp Glu Asn Ala Asn Leu Gly Thr Val Met Arg Tyr Glu Glu Ile Glu 
            180                 185                 190         


Leu Arg Ile Leu Leu Leu Cys Gly Ser Asp Leu Leu Glu Ser Phe Cys 
        195                 200                 205             


Ile Pro Gly Leu Trp Asn Glu Ala Asp Met Glu Val Ile Val Gly Asp 
    210                 215                 220                 


Phe Gly Ile Val Val Val Pro Arg Asp Ala Ala Asp Thr Asp Arg Ile 
225                 230                 235                 240 


Met Asn His Ser Ser Ile Leu Arg Lys Tyr Lys Asn Asn Ile Met Val 
                245                 250                 255     


Val Lys Asp Asp Ile Asn His Pro Met Ser Val Val Ser Ser Thr Lys 
            260                 265                 270         


Ser Arg Leu Ala Leu Gln His Gly Asp Gly His Val Val Asp Tyr Leu 
        275                 280                 285             


Ser Gln Pro Val Ile Asp Tyr Ile Leu Lys Ser Gln Leu Tyr Ile Asn 
    290                 295                 300                 


Ala Ser Gly 
305         


<210>  13
<211>  307
<212>  PRT
<213>  mouse

<400>  13

Met Thr Glu Thr Thr Lys Thr His Val Ile Leu Leu Ala Cys Gly Ser 
1               5                   10                  15      


Phe Asn Pro Ile Thr Lys Gly His Ile Gln Met Phe Glu Arg Ala Arg 
            20                  25                  30          


Asp Tyr Leu His Lys Thr Gly Arg Phe Ile Val Ile Gly Gly Ile Val 
        35                  40                  45              


Ser Pro Val His Asp Ser Tyr Gly Lys Gln Gly Leu Val Ser Ser Arg 
    50                  55                  60                  


His Arg Leu Ile Met Cys Gln Leu Ala Val Gln Asn Ser Asp Trp Ile 
65                  70                  75                  80  


Arg Val Asp Pro Trp Glu Cys Tyr Gln Asp Thr Trp Gln Thr Thr Cys 
                85                  90                  95      


Ser Val Leu Glu His His Arg Asp Leu Met Lys Arg Val Thr Gly Cys 
            100                 105                 110         


Ile Leu Ser Asn Val Asn Thr Pro Ser Met Thr Pro Val Ile Gly Gln 
        115                 120                 125             


Pro Gln His Glu Asn Thr Gln Pro Ile Tyr Gln Asn Ser Asn Val Pro 
    130                 135                 140                 


Thr Lys Pro Thr Ala Ala Lys Ile Leu Gly Lys Val Gly Glu Ser Leu 
145                 150                 155                 160 


Ser Arg Ile Cys Cys Val Arg Pro Pro Val Glu Arg Phe Thr Phe Val 
                165                 170                 175     


Asp Glu Asn Ala Asn Leu Gly Thr Val Met Arg Tyr Glu Glu Ile Glu 
            180                 185                 190         


Leu Arg Ile Leu Leu Leu Cys Gly Ser Asp Leu Leu Glu Ser Phe Cys 
        195                 200                 205             


Ile Pro Gly Leu Trp Asn Glu Ala Asp Met Glu Val Ile Val Gly Asp 
    210                 215                 220                 


Phe Gly Ile Val Val Val Pro Arg Asp Ala Ala Asp Thr Asp Arg Ile 
225                 230                 235                 240 


Met Asn His Ser Ser Ile Leu Arg Lys Tyr Lys Asn Asn Ile Met Val 
                245                 250                 255     


Val Lys Asp Asp Ile Asn His Pro Met Ser Val Val Ser Ser Thr Lys 
            260                 265                 270         


Ser Arg Leu Ala Leu Gln His Gly Asp Gly His Val Val Asp Tyr Leu 
        275                 280                 285             


Ser Gln Pro Val Ile Asp Tyr Ile Leu Lys Ser Gln Leu Tyr Ile Asn 
    290                 295                 300                 


Ala Ser Gly 
305         


<210>  14
<211>  307
<212>  PRT
<213>  dog

<400>  14

Met Thr Glu Thr Thr Lys Thr His Val Ile Leu Leu Ala Cys Gly Ser 
1               5                   10                  15      


Phe Asn Pro Ile Thr Lys Gly His Ile Gln Met Phe Glu Arg Ala Arg 
            20                  25                  30          


Asp Tyr Leu His Lys Thr Gly Arg Phe Ile Val Ile Gly Gly Ile Val 
        35                  40                  45              


Ser Pro Val His Asp Ser Tyr Gly Lys Gln Gly Leu Val Ser Ser Arg 
    50                  55                  60                  


His Arg Leu Ile Met Cys Gln Leu Ala Val Gln Asn Ser Asp Trp Ile 
65                  70                  75                  80  


Arg Val Asp Pro Trp Glu Cys Tyr Gln Asp Thr Trp Gln Thr Thr Cys 
                85                  90                  95      


Ser Val Leu Glu His His Arg Asp Leu Met Lys Arg Val Thr Gly Cys 
            100                 105                 110         


Ile Leu Ser Asn Val Asn Thr Pro Ser Met Thr Pro Val Ile Gly Gln 
        115                 120                 125             


Pro Gln Asn Glu Thr Pro Gln Pro Ile Tyr Gln Asn Ser Asn Val Ser 
    130                 135                 140                 


Thr Lys Pro Thr Ala Ala Lys Ile Leu Gly Lys Val Gly Glu Ser Leu 
145                 150                 155                 160 


Ser Arg Ile Cys Cys Val Arg Pro Pro Val Glu Arg Phe Thr Phe Val 
                165                 170                 175     


Asp Glu Asn Ala Asn Leu Gly Thr Val Met Arg Tyr Glu Glu Ile Glu 
            180                 185                 190         


Leu Arg Ile Leu Leu Leu Cys Gly Ser Asp Leu Leu Glu Ser Phe Cys 
        195                 200                 205             


Ile Pro Gly Leu Trp Asn Glu Ala Asp Met Glu Val Ile Val Gly Asp 
    210                 215                 220                 


Phe Gly Ile Val Val Val Pro Arg Asp Ala Ala Asp Thr Asp Arg Ile 
225                 230                 235                 240 


Met Asn His Ser Ser Ile Leu Arg Lys Tyr Lys Asn Asn Ile Met Val 
                245                 250                 255     


Val Lys Asp Asp Ile Asn His Pro Met Ser Val Val Ser Ser Thr Lys 
            260                 265                 270         


Ser Arg Leu Ala Leu Gln His Gly Asp Gly His Val Val Asp Tyr Leu 
        275                 280                 285             


Ser Gln Pro Val Ile Asp Tyr Ile Leu Lys Ser Gln Leu Tyr Ile Asn 
    290                 295                 300                 


Ala Ser Gly 
305         


<210>  15
<211>  142
<212>  PRT
<213>  human

<400>  15

Met Glu Gly Pro Asp His Gly Lys Ala Leu Phe Ser Thr Pro Ala Ala 
1               5                   10                  15      


Val Pro Glu Leu Lys Leu Leu Cys Gly Ala Asp Val Leu Lys Thr Phe 
            20                  25                  30          


Gln Thr Pro Asn Leu Trp Lys Asp Ala His Ile Gln Glu Ile Val Glu 
        35                  40                  45              


Lys Phe Gly Leu Val Cys Val Gly Arg Val Gly His Asp Pro Lys Gly 
    50                  55                  60                  


Tyr Ile Ala Glu Ser Pro Ile Leu Arg Met His Gln His Asn Ile His 
65                  70                  75                  80  


Leu Ala Lys Glu Pro Val Gln Asn Glu Ile Ser Ala Thr Tyr Ile Arg 
                85                  90                  95      


Arg Ala Leu Gly Gln Gly Gln Ser Val Lys Tyr Leu Ile Pro Asp Ala 
            100                 105                 110         


Val Ile Thr Tyr Ile Lys Asp His Gly Leu Tyr Thr Lys Gly Ser Thr 
        115                 120                 125             


Trp Lys Gly Lys Ser Thr Gln Ser Thr Glu Gly Lys Thr Ser 
    130                 135                 140         


<210>  16
<211>  179
<212>  PRT
<213>  mouse

<400>  16

Met Ala Arg Leu Ala Leu Gln Thr Ser Asp Trp Ile Arg Val Asp Pro 
1               5                   10                  15      


Trp Glu Ser Glu Gln Ala Gln Trp Met Glu Thr Val Lys Val Leu Arg 
            20                  25                  30          


His His His Arg Glu Leu Leu Arg Ser Ser Ala Gln Met Asp Gly Pro 
        35                  40                  45              


Asp Pro Ser Lys Thr Pro Ser Ala Ser Ala Ala Leu Pro Glu Leu Lys 
    50                  55                  60                  


Leu Leu Cys Gly Ala Asp Val Leu Lys Thr Phe Gln Thr Pro Asn Leu 
65                  70                  75                  80  


Trp Lys Asp Thr His Ile Gln Glu Ile Val Glu Lys Phe Gly Leu Val 
                85                  90                  95      


Cys Val Ser Arg Ser Gly His Asp Pro Glu Arg Tyr Ile Ser Asp Ser 
            100                 105                 110         


Pro Ile Leu Gln Gln Phe Gln His Asn Ile His Leu Ala Arg Glu Pro 
        115                 120                 125             


Val Leu Asn Glu Ile Ser Ala Thr Tyr Val Arg Lys Ala Leu Gly Gln 
    130                 135                 140                 


Gly Gln Ser Val Lys Tyr Leu Leu Pro Glu Ala Val Ile Thr Tyr Ile 
145                 150                 155                 160 


Arg Asp Gln Gly Leu Tyr Ile Asn Asp Gly Ser Trp Lys Gly Lys Gly 
                165                 170                 175     


Lys Thr Gly 
            


<210>  17
<211>  313
<212>  PRT
<213>  dog

<400>  17

Met Lys Ser Arg Ile Pro Val Val Leu Leu Ala Cys Gly Ser Phe Asn 
1               5                   10                  15      


Pro Ile Thr Asn Met His Leu Arg Leu Phe Glu Val Ala Arg Asp His 
            20                  25                  30          


Leu His Gln Thr Gly Trp Tyr Phe Ser Leu Leu Ser Pro Val Leu Val 
        35                  40                  45              


Ser Arg Arg Gln Glu Ser Leu Arg Ser Asn Leu Ser Arg Lys Gln Thr 
    50                  55                  60                  


Ser Ser Leu Cys Gln Asp Gly Gly Ile Gly Leu Tyr Gln Val Ile Gly 
65                  70                  75                  80  


Gly Ile Ile Ser Pro Val Asn Asp Asn Tyr Arg Lys Lys Asp Leu Val 
                85                  90                  95      


Ser Ala His His Arg Val Ala Met Ala Arg Leu Ala Leu Gln Thr Ser 
            100                 105                 110         


Asp Trp Val Arg Val Asp Pro Trp Glu Ser Glu Gln Val Gln Trp Met 
        115                 120                 125             


Glu Thr Val Lys Val Leu Arg Thr Phe Leu Thr Gln Met Ser Arg Lys 
    130                 135                 140                 


Thr Val Gln His His His Ser Glu Leu Leu Arg Ser Leu Pro Gln Thr 
145                 150                 155                 160 


Glu Gly Leu Asp His Gly Arg Ala Gly Ser Thr Ala Arg Thr Ala Gly 
                165                 170                 175     


Pro Glu Leu Lys Leu Leu Cys Gly Ala Asp Val Leu Lys Thr Phe Gln 
            180                 185                 190         


Thr Pro Asn Leu Trp Lys Asp Ala His Ile Gln Glu Ile Val Glu Lys 
        195                 200                 205             


Phe Gly Ile Val Cys Val Ser Arg Thr Gly His Asn Pro Lys Glu Tyr 
    210                 215                 220                 


Ile Ser Gly Ser Pro Ile Leu His Arg Tyr Arg His Asn Ile His Leu 
225                 230                 235                 240 


Ala Arg Glu Pro Val Gln Asn Glu Leu Ser Ser Thr Tyr Val Arg Gln 
                245                 250                 255     


Ala Leu Ser Gln Gly His Ser Val Lys Tyr Leu Leu Pro Asp Ala Val 
            260                 265                 270         


Ile Ala Tyr Ile Lys Asp His Asn Leu Tyr Thr Arg Asp Ser Ser Arg 
        275                 280                 285             


Lys Gly Ser Ser Thr Gln Arg Asn Glu Gly Lys Pro Ser Trp Gly Glu 
    290                 295                 300                 


Pro Ala Pro Pro Pro Arg Ser Ser Ser 
305                 310             


<210>  18
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Primer sequence

<400>  18
tagccttgtc agataaggaa gga                                               23


<210>  19
<211>  22
<212>  DNA
<213>  ARtificial

<220>
<223>  primer sequence

<400>  19
acagcttcac agtcaacttt gt                                                22


<210>  20
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  20
tgtgacagag agatggctgg                                                   20


<210>  21
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  21
atcttccaga tcctcaagcg                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Arificial

<400>  22
agctgcgctg atagacatcc                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  23
ctacctccac catgccaagt                                                   20


<210>  24
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  24
ctgtaacgat gaagccctgg ag                                                22


<210>  25
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  25
tggtgaggtt tgatccgcat                                                   20


<210>  26
<211>  25
<212>  DNA
<213>  ARtificial

<220>
<223>  primer sequence

<400>  26
gccaactatg ctggagctga tgccc                                             25


<210>  27
<211>  28
<212>  DNA
<213>  ARtificial

<220>
<223>  primer sequence

<400>  27
ggtgcgtgga gcgcaagttt gtcataag                                          28


<210>  28
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  28
ggcacaaact gctgaagcag aggc                                              24


<210>  29
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  29
ggtgctcctg aggttggtca tcagc                                             25


<210>  30
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  30
gagctactgg atgccagtga gcgc                                              24


<210>  31
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  31
ctggacgatg tcttccatct ctcc                                              24


<210>  32
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  32
ggcagcagca gctgcggaag cagagtctgg                                        30


<210>  33
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  33
gagtgctcct cagattggtc attagc                                            26


<210>  34
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  34
gttaagcagt acagccccaa a                                                 21


<210>  35
<211>  23
<212>  DNA
<213>  Artifical

<400>  35
agggcatatc caacaacaaa ctt                                               23


<210>  36
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  36
aggtcggtgt gaacggattt g                                                 21


<210>  37
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  37
tgtagaccat gtagttgagg tca                                               23


<210>  38
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  38
aactgttggt ggcctgaatc                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  39
aattctttgt gttgctgggg                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  40
ttcaaggcag ctcggtaact                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  41
gggcatttta cttccccaat                                                   20


<210>  42
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  42
tcaacacgac accggataaa c                                                 21


<210>  43
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  primer sequence

<400>  43
gccgcgagct atctttcttc a                                                 21


<210>  44
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  44
tcaacgtgaa ctcgttcggg                                                   20


<210>  45
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  45
acttcgcctt ggtgatgaga t                                                 21


<210>  46
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  46
gcaacagctc cttccacttc                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  47
gcctcagaca ctttgaagcc                                                   20


<210>  48
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  48
gttgtcgacg acgagcg                                                      17


<210>  49
<211>  17
<212>  DNA
<213>  ARtificial

<220>
<223>  primer sequence

<400>  49
gcacagagcc tcgcctt                                                      17


<210>  50
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  50
accctttcca aatcctcagc                                                   20


<210>  51
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  primer sequence

<400>  51
gttatggcga cccgcag                                                      17


