       
<110>     Ļ     (  "")
            LIMITED LIABILITY COMPANY "DRD" (LLC "DRD")
<120>          (   )   
<130> 000000702

<150> RU 2016150481
<151> 2016-12-21

<160> 2

<210> 1
<211> 908
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Ile Ile Phe Pro Ile Leu Ser Asn Pro Val Phe Arg Arg Thr 
1               5                   10                  15      
Val Lys Leu Leu Leu Cys Leu Leu Trp Ile Gly Tyr Ser Gln Gly Thr 
            20                  25                  30          
Thr His Val Leu Arg Phe Gly Gly Ile Phe Glu Tyr Val Glu Ser Gly 
        35                  40                  45              
Pro Met Gly Ala Glu Glu Leu Ala Phe Arg Phe Ala Val Asn Thr Ile 
    50                  55                  60                  
Asn Arg Asn Arg Thr Leu Leu Pro Asn Thr Thr Leu Thr Tyr Asp Thr 
65                  70                  75                  80  
Gln Lys Ile Asn Leu Tyr Asp Ser Phe Glu Ala Ser Lys Lys Ala Cys 
                85                  90                  95      
Asp Gln Leu Ser Leu Gly Val Ala Ala Ile Phe Gly Pro Ser His Ser 
            100                 105                 110         
Ser Ser Ala Asn Ala Val Gln Ser Ile Cys Asn Ala Leu Gly Val Pro 
        115                 120                 125             
His Ile Gln Thr Arg Trp Lys His Gln Val Ser Asp Asn Lys Asp Ser 
    130                 135                 140                 
Phe Tyr Val Ser Leu Tyr Pro Asp Phe Ser Ser Leu Ser Arg Ala Ile 
145                 150                 155                 160 
Leu Asp Leu Val Gln Phe Phe Lys Trp Lys Thr Val Thr Val Val Tyr 
                165                 170                 175     
Asp Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile Lys Ala Pro 
            180                 185                 190         
Ser Arg Tyr Asn Leu Arg Leu Lys Ile Arg Gln Leu Pro Ala Asp Thr 
        195                 200                 205             
Lys Asp Ala Lys Pro Leu Leu Lys Glu Met Lys Arg Gly Lys Glu Phe 
    210                 215                 220                 
His Val Ile Phe Asp Cys Ser His Glu Met Ala Ala Gly Ile Leu Lys 
225                 230                 235                 240 
Gln Ala Leu Ala Met Gly Met Met Thr Glu Tyr Tyr His Tyr Ile Phe 
                245                 250                 255     
Thr Thr Leu Asp Leu Phe Ala Leu Asp Val Glu Pro Tyr Arg Tyr Ser 
            260                 265                 270         
Gly Val Asn Met Thr Gly Phe Arg Ile Leu Asn Thr Glu Asn Thr Gln 
        275                 280                 285             
Val Ser Ser Ile Ile Glu Lys Trp Ser Met Glu Arg Leu Gln Ala Pro 
    290                 295                 300                 
Pro Lys Pro Asp Ser Gly Leu Leu Asp Gly Phe Met Thr Thr Asp Ala 
305                 310                 315                 320 
Ala Leu Met Tyr Asp Ala Val His Val Val Ser Val Ala Val Gln Gln 
                325                 330                 335     
Phe Pro Gln Met Thr Val Ser Ser Leu Gln Cys Asn Arg His Lys Pro 
            340                 345                 350         
Trp Arg Phe Gly Thr Arg Phe Met Ser Leu Ile Lys Glu Ala His Trp 
        355                 360                 365             
Glu Gly Leu Thr Gly Arg Ile Thr Phe Asn Lys Thr Asn Gly Leu Arg 
    370                 375                 380                 
Thr Asp Phe Asp Leu Asp Val Ile Ser Leu Lys Glu Glu Gly Leu Glu 
385                 390                 395                 400 
Lys Ile Gly Thr Trp Asp Pro Ala Ser Gly Leu Asn Met Thr Glu Asn 
                405                 410                 415     
Gln Lys Gly Lys Pro Ala Asn Ile Thr Asp Ser Leu Ser Asn Arg Ser 
            420                 425                 430         
Leu Ile Val Thr Thr Ile Leu Glu Glu Pro Tyr Val Leu Phe Lys Lys 
        435                 440                 445             
Ser Asp Lys Pro Leu Tyr Gly Asn Asp Arg Phe Glu Gly Tyr Cys Ile 
    450                 455                 460                 
Asp Leu Leu Arg Glu Leu Ser Thr Ile Leu Gly Phe Thr Tyr Glu Ile 
465                 470                 475                 480 
Arg Leu Val Glu Asp Gly Lys Tyr Gly Ala Gln Asp Asp Ala Asn Gly 
                485                 490                 495     
Gln Trp Asn Gly Met Val Arg Glu Leu Ile Asp His Lys Ala Asp Leu 
            500                 505                 510         
Ala Val Ala Pro Leu Ala Ile Thr Tyr Val Arg Glu Lys Val Ile Asp 
        515                 520                 525             
Phe Ser Lys Pro Phe Met Thr Leu Gly Ile Ser Ile Leu Tyr Arg Lys 
    530                 535                 540                 
Pro Asn Gly Thr Asn Pro Gly Val Phe Ser Phe Leu Asn Pro Leu Ser 
545                 550                 555                 560 
Pro Asp Ile Trp Met Tyr Ile Leu Leu Ala Tyr Leu Gly Val Ser Cys 
                565                 570                 575     
Val Leu Phe Val Ile Ala Arg Phe Ser Pro Tyr Glu Trp Tyr Asn Pro 
            580                 585                 590         
His Pro Cys Asn Pro Asp Ser Asp Val Val Glu Asn Asn Phe Thr Leu 
        595                 600                 605             
Leu Asn Ser Phe Trp Phe Gly Val Gly Ala Leu Met Gln Gln Gly Ser 
    610                 615                 620                 
Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Val Gly Gly Ile Trp 
625                 630                 635                 640 
Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn Leu Ala 
                645                 650                 655     
Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser Ala Asp 
            660                 665                 670         
Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Glu Asp Gly 
        675                 680                 685             
Ala Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Tyr Asp Lys 
    690                 695                 700                 
Met Trp Ala Phe Met Ser Ser Arg Arg Gln Ser Val Leu Val Lys Ser 
705                 710                 715                 720 
Asn Glu Glu Gly Ile Gln Arg Val Leu Thr Ser Asp Tyr Ala Phe Leu 
                725                 730                 735     
Met Glu Ser Thr Thr Ile Glu Phe Val Thr Gln Arg Asn Cys Asn Leu 
            740                 745                 750         
Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Val Gly Thr 
        755                 760                 765             
Pro Met Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu Gln 
    770                 775                 780                 
Leu Gln Glu Glu Gly Lys Leu His Met Met Lys Glu Lys Trp Trp Arg 
785                 790                 795                 800 
Gly Asn Gly Cys Pro Glu Glu Glu Ser Lys Glu Ala Ser Ala Leu Gly 
                805                 810                 815     
Val Gln Asn Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu Val 
            820                 825                 830         
Leu Ser Val Phe Val Ala Val Gly Glu Phe Leu Tyr Lys Ser Lys Lys 
        835                 840                 845             
Asn Ala Gln Leu Glu Lys Arg Ser Phe Cys Ser Ala Met Val Glu Glu 
    850                 855                 860                 
Leu Arg Met Ser Leu Lys Cys Gln Arg Arg Leu Lys His Lys Pro Gln 
865                 870                 875                 880 
Ala Pro Val Ile Val Lys Thr Glu Glu Val Ile Asn Met His Thr Phe 
                885                 890                 895     
Asn Asp Arg Arg Leu Pro Gly Lys Glu Thr Met Ala 
            900                 905             

<210> 2
<211> 919
<212> PRT
<213> Homo sapiens


<400> 2
Met Thr Ala Pro Trp Arg Arg Leu Arg Ser Leu Val Trp Glu Tyr Trp 
1               5                   10                  15      
Ala Gly Leu Leu Val Cys Ala Phe Trp Ile Pro Asp Ser Arg Gly Met 
            20                  25                  30          
Pro His Val Ile Arg Ile Gly Gly Ile Phe Glu Tyr Ala Asp Gly Pro 
        35                  40                  45              
Asn Ala Gln Val Met Asn Ala Glu Glu His Ala Phe Arg Phe Ser Ala 
    50                  55                  60                  
Asn Ile Ile Asn Arg Asn Arg Thr Leu Leu Pro Asn Thr Thr Leu Thr 
65                  70                  75                  80  
Tyr Asp Ile Gln Arg Ile His Phe His Asp Ser Phe Glu Ala Thr Lys 
                85                  90                  95      
Lys Ala Cys Asp Gln Leu Ala Leu Gly Val Val Ala Ile Phe Gly Pro 
            100                 105                 110         
Ser Gln Gly Ser Cys Thr Asn Ala Val Gln Ser Ile Cys Asn Ala Leu 
        115                 120                 125             
Glu Val Pro His Ile Gln Leu Arg Trp Lys His His Pro Leu Asp Asn 
    130                 135                 140                 
Lys Asp Thr Phe Tyr Val Asn Leu Tyr Pro Asp Tyr Ala Ser Leu Ser 
145                 150                 155                 160 
His Ala Ile Leu Asp Leu Val Gln Tyr Leu Lys Trp Arg Ser Ala Thr 
                165                 170                 175     
Val Val Tyr Asp Asp Ser Thr Gly Leu Ile Arg Leu Gln Glu Leu Ile 
            180                 185                 190         
Met Ala Pro Ser Arg Tyr Asn Ile Arg Leu Lys Ile Arg Gln Leu Pro 
        195                 200                 205             
Ile Asp Ser Asp Asp Ser Arg Pro Leu Leu Lys Glu Met Lys Arg Gly 
    210                 215                 220                 
Arg Glu Phe Arg Ile Ile Phe Asp Cys Ser His Thr Met Ala Ala Gln 
225                 230                 235                 240 
Ile Leu Lys Gln Ala Met Ala Met Gly Met Met Thr Glu Tyr Tyr His 
                245                 250                 255     
Phe Ile Phe Thr Thr Leu Asp Leu Tyr Ala Leu Asp Leu Glu Pro Tyr 
            260                 265                 270         
Arg Tyr Ser Gly Val Asn Leu Thr Gly Phe Arg Ile Leu Asn Val Asp 
        275                 280                 285             
Asn Pro His Val Ser Ala Ile Val Glu Lys Trp Ser Met Glu Arg Leu 
    290                 295                 300                 
Gln Ala Ala Pro Arg Ser Glu Ser Gly Leu Leu Asp Gly Val Met Met 
305                 310                 315                 320 
Thr Asp Ala Ala Leu Leu Tyr Asp Ala Val His Ile Val Ser Val Cys 
                325                 330                 335     
Tyr Gln Arg Ala Pro Gln Met Thr Val Asn Ser Leu Gln Cys His Arg 
            340                 345                 350         
His Lys Ala Trp Arg Phe Gly Gly Arg Phe Met Asn Phe Ile Lys Glu 
        355                 360                 365             
Ala Gln Trp Glu Gly Leu Thr Gly Arg Ile Val Phe Asn Lys Thr Ser 
    370                 375                 380                 
Gly Leu Arg Thr Asp Phe Asp Leu Asp Ile Ile Ser Leu Lys Glu Asp 
385                 390                 395                 400 
Gly Leu Glu Lys Val Gly Val Trp Ser Pro Ala Asp Gly Leu Asn Ile 
                405                 410                 415     
Thr Glu Val Ala Lys Gly Arg Gly Pro Asn Val Thr Asp Ser Leu Thr 
            420                 425                 430         
Asn Arg Ser Leu Ile Val Thr Thr Val Leu Glu Glu Pro Phe Val Met 
        435                 440                 445             
Phe Arg Lys Ser Asp Arg Thr Leu Tyr Gly Asn Asp Arg Phe Glu Gly 
    450                 455                 460                 
Tyr Cys Ile Asp Leu Leu Lys Glu Leu Ala His Ile Leu Gly Phe Ser 
465                 470                 475                 480 
Tyr Glu Ile Arg Leu Val Glu Asp Gly Lys Tyr Gly Ala Gln Asp Asp 
                485                 490                 495     
Lys Gly Gln Trp Asn Gly Met Val Lys Glu Leu Ile Asp His Lys Ala 
            500                 505                 510         
Asp Leu Ala Val Ala Pro Leu Thr Ile Thr His Val Arg Glu Lys Ala 
        515                 520                 525             
Ile Asp Phe Ser Lys Pro Phe Met Thr Leu Gly Val Ser Ile Leu Tyr 
    530                 535                 540                 
Arg Lys Pro Asn Gly Thr Asn Pro Ser Val Phe Ser Phe Leu Asn Pro 
545                 550                 555                 560 
Leu Ser Pro Asp Ile Trp Met Tyr Val Leu Leu Ala Tyr Leu Gly Val 
                565                 570                 575     
Ser Cys Val Leu Phe Val Ile Ala Arg Phe Ser Pro Tyr Glu Trp Tyr 
            580                 585                 590         
Asp Ala His Pro Cys Asn Pro Gly Ser Glu Val Val Glu Asn Asn Phe 
        595                 600                 605             
Thr Leu Leu Asn Ser Phe Trp Phe Gly Met Gly Ser Leu Met Gln Gln 
    610                 615                 620                 
Gly Ser Glu Leu Met Pro Lys Ala Leu Ser Thr Arg Ile Ile Gly Gly 
625                 630                 635                 640 
Ile Trp Trp Phe Phe Thr Leu Ile Ile Ile Ser Ser Tyr Thr Ala Asn 
                645                 650                 655     
Leu Ala Ala Phe Leu Thr Val Glu Arg Met Glu Ser Pro Ile Asp Ser 
            660                 665                 670         
Ala Asp Asp Leu Ala Lys Gln Thr Lys Ile Glu Tyr Gly Ala Val Lys 
        675                 680                 685             
Asp Gly Ala Thr Met Thr Phe Phe Lys Lys Ser Lys Ile Ser Thr Phe 
    690                 695                 700                 
Glu Lys Met Trp Ala Phe Met Ser Ser Lys Pro Ser Ala Leu Val Lys 
705                 710                 715                 720 
Asn Asn Glu Glu Gly Ile Gln Arg Ala Leu Thr Ala Asp Tyr Ala Leu 
                725                 730                 735     
Leu Met Glu Ser Thr Thr Ile Glu Tyr Val Thr Gln Arg Asn Cys Asn 
            740                 745                 750         
Leu Thr Gln Ile Gly Gly Leu Ile Asp Ser Lys Gly Tyr Gly Ile Gly 
        755                 760                 765             
Thr Pro Met Gly Ser Pro Tyr Arg Asp Lys Ile Thr Ile Ala Ile Leu 
    770                 775                 780                 
Gln Leu Gln Glu Glu Asp Lys Leu His Ile Met Lys Glu Lys Trp Trp 
785                 790                 795                 800 
Arg Gly Ser Gly Cys Pro Glu Glu Glu Asn Lys Glu Ala Ser Ala Leu 
                805                 810                 815     
Gly Ile Gln Lys Ile Gly Gly Ile Phe Ile Val Leu Ala Ala Gly Leu 
            820                 825                 830         
Val Leu Ser Val Leu Val Ala Val Gly Glu Phe Val Tyr Lys Leu Arg 
        835                 840                 845             
Lys Thr Ala Glu Arg Glu Gln Arg Ser Phe Cys Ser Thr Val Ala Asp 
    850                 855                 860                 
Glu Ile Arg Phe Ser Leu Thr Cys Gln Arg Arg Val Lys His Lys Pro 
865                 870                 875                 880 
Gln Pro Pro Met Met Val Lys Thr Asp Ala Val Ile Asn Met His Thr 
                885                 890                 895     
Phe Asn Asp Arg Arg Leu Pro Gly Lys Asp Ser Met Ala Cys Ser Thr 
            900                 905                 910         
Ser Leu Ala Pro Val Phe Pro 
        915                 

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