                         SEQUENCE LISTING

<110>  ONCOMED PHARMACEUTICALS, INC.
       GURNEY, AUSTIN L
       PARK, INKYUNG 
       AXELROD, FUMIKO TAKADA
 
<120>  LYMPHOTOXIN-BETA RECEPTOR-BINDING AGENTS, TARGETING ANTIBODIES, 
       AND USES THEREOF

<130>  2293.165PC02/PAC/E-H/M-S

<140>  PCT/US2017/067671
<141>  2017-12-20

<150>  62/436,616
<151>  2016-12-20

<150>  62/455,398
<151>  2017-02-06

<160>  108   

<170>  PatentIn version 3.5

<210>  1
<211>  202
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lymphotoxin-alpha amino acid sequence


<220>
<221>  misc_feature
<222>  (1)..(33)
<223>  predicted signal sequence

<400>  1

Met Thr Leu Leu Gly Arg Leu His Leu Leu Arg Val Leu Gly Thr Pro 
1               5                   10                  15      


Pro Val Phe Leu Leu Gly Leu Leu Leu Ala Leu Pro Leu Gly Ala Gln 
            20                  25                  30          


Gly Leu Ser Gly Val Arg Phe Ser Ala Ala Arg Thr Ala His Pro Leu 
        35                  40                  45              


Pro Gln Lys His Leu Thr His Gly Ile Leu Lys Pro Ala Ala His Leu 
    50                  55                  60                  


Val Gly Tyr Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg Ala Ser Thr 
65                  70                  75                  80  


Asp Arg Ala Phe Leu Arg His Gly Phe Ser Leu Ser Asn Asn Ser Leu 
                85                  90                  95      


Leu Ile Pro Thr Ser Gly Leu Tyr Phe Val Tyr Ser Gln Val Val Phe 
            100                 105                 110         


Ser Gly Glu Ser Cys Ser Pro Arg Ala Ile Pro Thr Pro Ile Tyr Leu 
        115                 120                 125             


Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe His Val Pro 
    130                 135                 140                 


Leu Leu Ser Ala Gln Lys Ser Val Tyr Pro Gly Leu Gln Gly Pro Trp 
145                 150                 155                 160 


Val Arg Ser Met Tyr Gln Gly Ala Val Phe Leu Leu Ser Lys Gly Asp 
                165                 170                 175     


Gln Leu Ser Thr His Thr Asp Gly Ile Ser His Leu His Phe Ser Pro 
            180                 185                 190         


Ser Ser Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200         


<210>  2
<211>  169
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lymphotoxin-alpha amino acid sequence

<400>  2

Leu Ser Gly Val Arg Phe Ser Ala Ala Arg Thr Ala His Pro Leu Pro 
1               5                   10                  15      


Gln Lys His Leu Thr His Gly Ile Leu Lys Pro Ala Ala His Leu Val 
            20                  25                  30          


Gly Tyr Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg Ala Ser Thr Asp 
        35                  40                  45              


Arg Ala Phe Leu Arg His Gly Phe Ser Leu Ser Asn Asn Ser Leu Leu 
    50                  55                  60                  


Ile Pro Thr Ser Gly Leu Tyr Phe Val Tyr Ser Gln Val Val Phe Ser 
65                  70                  75                  80  


Gly Glu Ser Cys Ser Pro Arg Ala Ile Pro Thr Pro Ile Tyr Leu Ala 
                85                  90                  95      


His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe His Val Pro Leu 
            100                 105                 110         


Leu Ser Ala Gln Lys Ser Val Tyr Pro Gly Leu Gln Gly Pro Trp Val 
        115                 120                 125             


Arg Ser Met Tyr Gln Gly Ala Val Phe Leu Leu Ser Lys Gly Asp Gln 
    130                 135                 140                 


Leu Ser Thr His Thr Asp Gly Ile Ser His Leu His Phe Ser Pro Ser 
145                 150                 155                 160 


Ser Val Phe Phe Gly Ala Phe Ala Leu 
                165                 


<210>  3
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lymphotoxin-alpha (aa 59-202)

<400>  3

Lys Pro Ala Ala His Leu Val Gly Tyr Pro Ser Lys Gln Asn Ser Leu 
1               5                   10                  15      


Leu Trp Arg Ala Ser Thr Asp Arg Ala Phe Leu Arg His Gly Phe Ser 
            20                  25                  30          


Leu Ser Asn Asn Ser Leu Leu Ile Pro Thr Ser Gly Leu Tyr Phe Val 
        35                  40                  45              


Tyr Ser Gln Val Val Phe Ser Gly Glu Ser Cys Ser Pro Arg Ala Ile 
    50                  55                  60                  


Pro Thr Pro Ile Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln 
65                  70                  75                  80  


Tyr Pro Phe His Val Pro Leu Leu Ser Ala Gln Lys Ser Val Tyr Pro 
                85                  90                  95      


Gly Leu Gln Gly Pro Trp Val Arg Ser Met Tyr Gln Gly Ala Val Phe 
            100                 105                 110         


Leu Leu Ser Lys Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Ser 
        115                 120                 125             


His Leu His Phe Ser Pro Ser Ser Val Phe Phe Gly Ala Phe Ala Leu 
    130                 135                 140                 


<210>  4
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lymphotoxin-beta amino acid sequence

<400>  4

Met Gly Thr Arg Gly Leu Gln Gly Leu Gly Gly Arg Pro Gln Gly Arg 
1               5                   10                  15      


Gly Cys Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Arg Arg Val Glu Lys Ile Ile Gly Ser Gly Ala Gln 
    50                  55                  60                  


Ala Gln Lys Arg Leu Asp Asp Ser Lys Pro Ser Cys Ile Leu Pro Ser 
65                  70                  75                  80  


Pro Ser Ser Leu Ser Glu Thr Pro Asp Pro Arg Leu His Pro Gln Arg 
                85                  90                  95      


Ser Asn Ala Ser Arg Asn Leu Ala Ser Thr Ser Gln Gly Pro Val Ala 
            100                 105                 110         


Gln Ser Ser Arg Glu Ala Ser Ala Trp Met Thr Ile Leu Ser Pro Ala 
        115                 120                 125             


Ala Asp Ser Thr Pro Asp Pro Gly Val Gln Gln Leu Pro Lys Gly Glu 
    130                 135                 140                 


Pro Glu Thr Asp Leu Asn Pro Glu Leu Pro Ala Ala His Leu Ile Gly 
145                 150                 155                 160 


Ala Trp Met Ser Gly Gln Gly Leu Ser Trp Glu Ala Ser Gln Glu Glu 
                165                 170                 175     


Ala Phe Leu Arg Ser Gly Ala Gln Phe Ser Pro Thr His Gly Leu Ala 
            180                 185                 190         


Leu Pro Gln Asp Gly Val Tyr Tyr Leu Tyr Cys His Val Gly Tyr Arg 
        195                 200                 205             


Gly Arg Thr Pro Pro Ala Gly Arg Ser Arg Ala Arg Ser Leu Thr Leu 
    210                 215                 220                 


Arg Ser Ala Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Arg Gly Ser Pro 
225                 230                 235                 240 


Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Val Asp Pro 
                245                 250                 255     


Ile Gly Tyr Gly Ser Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu 
            260                 265                 270         


Ala Gln Leu Arg Ser Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro 
        275                 280                 285             


Asp Met Val Asp Tyr Arg Arg Gly Lys Thr Phe Phe Gly Ala Val Met 
    290                 295                 300                 


Val Gly 
305     


<210>  5
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lymphotoxin-beta extracellular domain (aa 49-306)

<400>  5

Gln Asp Gln Gly Arg Arg Val Glu Lys Ile Ile Gly Ser Gly Ala Gln 
1               5                   10                  15      


Ala Gln Lys Arg Leu Asp Asp Ser Lys Pro Ser Cys Ile Leu Pro Ser 
            20                  25                  30          


Pro Ser Ser Leu Ser Glu Thr Pro Asp Pro Arg Leu His Pro Gln Arg 
        35                  40                  45              


Ser Asn Ala Ser Arg Asn Leu Ala Ser Thr Ser Gln Gly Pro Val Ala 
    50                  55                  60                  


Gln Ser Ser Arg Glu Ala Ser Ala Trp Met Thr Ile Leu Ser Pro Ala 
65                  70                  75                  80  


Ala Asp Ser Thr Pro Asp Pro Gly Val Gln Gln Leu Pro Lys Gly Glu 
                85                  90                  95      


Pro Glu Thr Asp Leu Asn Pro Glu Leu Pro Ala Ala His Leu Ile Gly 
            100                 105                 110         


Ala Trp Met Ser Gly Gln Gly Leu Ser Trp Glu Ala Ser Gln Glu Glu 
        115                 120                 125             


Ala Phe Leu Arg Ser Gly Ala Gln Phe Ser Pro Thr His Gly Leu Ala 
    130                 135                 140                 


Leu Pro Gln Asp Gly Val Tyr Tyr Leu Tyr Cys His Val Gly Tyr Arg 
145                 150                 155                 160 


Gly Arg Thr Pro Pro Ala Gly Arg Ser Arg Ala Arg Ser Leu Thr Leu 
                165                 170                 175     


Arg Ser Ala Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Arg Gly Ser Pro 
            180                 185                 190         


Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Val Asp Pro 
        195                 200                 205             


Ile Gly Tyr Gly Ser Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu 
    210                 215                 220                 


Ala Gln Leu Arg Ser Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro 
225                 230                 235                 240 


Asp Met Val Asp Tyr Arg Arg Gly Lys Thr Phe Phe Gly Ala Val Met 
                245                 250                 255     


Val Gly 
        


<210>  6
<211>  158
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lymphotoxin-beta (aa 149-306)

<400>  6

Leu Asn Pro Glu Leu Pro Ala Ala His Leu Ile Gly Ala Trp Met Ser 
1               5                   10                  15      


Gly Gln Gly Leu Ser Trp Glu Ala Ser Gln Glu Glu Ala Phe Leu Arg 
            20                  25                  30          


Ser Gly Ala Gln Phe Ser Pro Thr His Gly Leu Ala Leu Pro Gln Asp 
        35                  40                  45              


Gly Val Tyr Tyr Leu Tyr Cys His Val Gly Tyr Arg Gly Arg Thr Pro 
    50                  55                  60                  


Pro Ala Gly Arg Ser Arg Ala Arg Ser Leu Thr Leu Arg Ser Ala Leu 
65                  70                  75                  80  


Tyr Arg Ala Gly Gly Ala Tyr Gly Arg Gly Ser Pro Glu Leu Leu Leu 
                85                  90                  95      


Glu Gly Ala Glu Thr Val Thr Pro Val Val Asp Pro Ile Gly Tyr Gly 
            100                 105                 110         


Ser Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu Ala Gln Leu Arg 
        115                 120                 125             


Ser Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro Asp Met Val Asp 
    130                 135                 140                 


Tyr Arg Arg Gly Lys Thr Phe Phe Gly Ala Val Met Val Gly 
145                 150                 155             


<210>  7
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lymphotoxin alpha, beta, beta single-chain trimer amino 
       acid sequence without a signal sequence

<400>  7

Lys Pro Ala Ala His Leu Val Gly Tyr Pro Ser Lys Gln Asn Ser Leu 
1               5                   10                  15      


Leu Trp Arg Ala Ser Thr Asp Arg Ala Phe Leu Arg His Gly Phe Ser 
            20                  25                  30          


Leu Ser Asn Asn Ser Leu Leu Ile Pro Thr Ser Gly Leu Tyr Phe Val 
        35                  40                  45              


Tyr Ser Gln Val Val Phe Ser Gly Glu Ser Cys Ser Pro Arg Ala Ile 
    50                  55                  60                  


Pro Thr Pro Ile Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln 
65                  70                  75                  80  


Tyr Pro Phe His Val Pro Leu Leu Ser Ala Gln Lys Ser Val Tyr Pro 
                85                  90                  95      


Gly Leu Gln Gly Pro Trp Val Arg Ser Met Tyr Gln Gly Ala Val Phe 
            100                 105                 110         


Leu Leu Ser Lys Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Ser 
        115                 120                 125             


His Leu His Phe Ser Pro Ser Ser Val Phe Phe Gly Ala Phe Ala Leu 
    130                 135                 140                 


Leu Asn Pro Glu Leu Pro Ala Ala His Leu Ile Gly Ala Trp Met Ser 
145                 150                 155                 160 


Gly Gln Gly Leu Ser Trp Glu Ala Ser Gln Glu Glu Ala Phe Leu Arg 
                165                 170                 175     


Ser Gly Ala Gln Phe Ser Pro Thr His Gly Leu Ala Leu Pro Gln Asp 
            180                 185                 190         


Gly Val Tyr Tyr Leu Tyr Cys His Val Gly Tyr Arg Gly Arg Thr Pro 
        195                 200                 205             


Pro Ala Gly Arg Ser Arg Ala Arg Ser Leu Thr Leu Arg Ser Ala Leu 
    210                 215                 220                 


Tyr Arg Ala Gly Gly Ala Tyr Gly Arg Gly Ser Pro Glu Leu Leu Leu 
225                 230                 235                 240 


Glu Gly Ala Glu Thr Val Thr Pro Val Val Asp Pro Ile Gly Tyr Gly 
                245                 250                 255     


Ser Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu Ala Gln Leu Arg 
            260                 265                 270         


Ser Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro Asp Met Val Asp 
        275                 280                 285             


Tyr Arg Arg Gly Lys Thr Phe Phe Gly Ala Val Met Val Gly Leu Asn 
    290                 295                 300                 


Pro Glu Leu Pro Ala Ala His Leu Ile Gly Ala Trp Met Ser Gly Gln 
305                 310                 315                 320 


Gly Leu Ser Trp Glu Ala Ser Gln Glu Glu Ala Phe Leu Arg Ser Gly 
                325                 330                 335     


Ala Gln Phe Ser Pro Thr His Gly Leu Ala Leu Pro Gln Asp Gly Val 
            340                 345                 350         


Tyr Tyr Leu Tyr Cys His Val Gly Tyr Arg Gly Arg Thr Pro Pro Ala 
        355                 360                 365             


Gly Arg Ser Arg Ala Arg Ser Leu Thr Leu Arg Ser Ala Leu Tyr Arg 
    370                 375                 380                 


Ala Gly Gly Ala Tyr Gly Arg Gly Ser Pro Glu Leu Leu Leu Glu Gly 
385                 390                 395                 400 


Ala Glu Thr Val Thr Pro Val Val Asp Pro Ile Gly Tyr Gly Ser Leu 
                405                 410                 415     


Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu Ala Gln Leu Arg Ser Gly 
            420                 425                 430         


Glu Arg Val Tyr Val Asn Ile Ser His Pro Asp Met Val Asp Tyr Arg 
        435                 440                 445             


Arg Gly Lys Thr Phe Phe Gly Ala Val Met Val Gly 
    450                 455                 460 


<210>  8
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lymphotoxin Beta, alpha, beta single-chain trimer amino 
       acid sequence without a signal sequence

<400>  8

Leu Asn Pro Glu Leu Pro Ala Ala His Leu Ile Gly Ala Trp Met Ser 
1               5                   10                  15      


Gly Gln Gly Leu Ser Trp Glu Ala Ser Gln Glu Glu Ala Phe Leu Arg 
            20                  25                  30          


Ser Gly Ala Gln Phe Ser Pro Thr His Gly Leu Ala Leu Pro Gln Asp 
        35                  40                  45              


Gly Val Tyr Tyr Leu Tyr Cys His Val Gly Tyr Arg Gly Arg Thr Pro 
    50                  55                  60                  


Pro Ala Gly Arg Ser Arg Ala Arg Ser Leu Thr Leu Arg Ser Ala Leu 
65                  70                  75                  80  


Tyr Arg Ala Gly Gly Ala Tyr Gly Arg Gly Ser Pro Glu Leu Leu Leu 
                85                  90                  95      


Glu Gly Ala Glu Thr Val Thr Pro Val Val Asp Pro Ile Gly Tyr Gly 
            100                 105                 110         


Ser Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu Ala Gln Leu Arg 
        115                 120                 125             


Ser Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro Asp Met Val Asp 
    130                 135                 140                 


Tyr Arg Arg Gly Lys Thr Phe Phe Gly Ala Val Met Val Gly Lys Pro 
145                 150                 155                 160 


Ala Ala His Leu Val Gly Tyr Pro Ser Lys Gln Asn Ser Leu Leu Trp 
                165                 170                 175     


Arg Ala Ser Thr Asp Arg Ala Phe Leu Arg His Gly Phe Ser Leu Ser 
            180                 185                 190         


Asn Asn Ser Leu Leu Ile Pro Thr Ser Gly Leu Tyr Phe Val Tyr Ser 
        195                 200                 205             


Gln Val Val Phe Ser Gly Glu Ser Cys Ser Pro Arg Ala Ile Pro Thr 
    210                 215                 220                 


Pro Ile Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro 
225                 230                 235                 240 


Phe His Val Pro Leu Leu Ser Ala Gln Lys Ser Val Tyr Pro Gly Leu 
                245                 250                 255     


Gln Gly Pro Trp Val Arg Ser Met Tyr Gln Gly Ala Val Phe Leu Leu 
            260                 265                 270         


Ser Lys Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Ser His Leu 
        275                 280                 285             


His Phe Ser Pro Ser Ser Val Phe Phe Gly Ala Phe Ala Leu Leu Asn 
    290                 295                 300                 


Pro Glu Leu Pro Ala Ala His Leu Ile Gly Ala Trp Met Ser Gly Gln 
305                 310                 315                 320 


Gly Leu Ser Trp Glu Ala Ser Gln Glu Glu Ala Phe Leu Arg Ser Gly 
                325                 330                 335     


Ala Gln Phe Ser Pro Thr His Gly Leu Ala Leu Pro Gln Asp Gly Val 
            340                 345                 350         


Tyr Tyr Leu Tyr Cys His Val Gly Tyr Arg Gly Arg Thr Pro Pro Ala 
        355                 360                 365             


Gly Arg Ser Arg Ala Arg Ser Leu Thr Leu Arg Ser Ala Leu Tyr Arg 
    370                 375                 380                 


Ala Gly Gly Ala Tyr Gly Arg Gly Ser Pro Glu Leu Leu Leu Glu Gly 
385                 390                 395                 400 


Ala Glu Thr Val Thr Pro Val Val Asp Pro Ile Gly Tyr Gly Ser Leu 
                405                 410                 415     


Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu Ala Gln Leu Arg Ser Gly 
            420                 425                 430         


Glu Arg Val Tyr Val Asn Ile Ser His Pro Asp Met Val Asp Tyr Arg 
        435                 440                 445             


Arg Gly Lys Thr Phe Phe Gly Ala Val Met Val Gly 
    450                 455                 460 


<210>  9
<211>  460
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse Lymphotoxin beta, beta, alpha single-chain trimer amino acid sequence without a signal sequence  

<400>  9

Leu Asn Pro Glu Leu Pro Ala Ala His Leu Ile Gly Ala Trp Met Ser 
1               5                   10                  15      


Gly Gln Gly Leu Ser Trp Glu Ala Ser Gln Glu Glu Ala Phe Leu Arg 
            20                  25                  30          


Ser Gly Ala Gln Phe Ser Pro Thr His Gly Leu Ala Leu Pro Gln Asp 
        35                  40                  45              


Gly Val Tyr Tyr Leu Tyr Cys His Val Gly Tyr Arg Gly Arg Thr Pro 
    50                  55                  60                  


Pro Ala Gly Arg Ser Arg Ala Arg Ser Leu Thr Leu Arg Ser Ala Leu 
65                  70                  75                  80  


Tyr Arg Ala Gly Gly Ala Tyr Gly Arg Gly Ser Pro Glu Leu Leu Leu 
                85                  90                  95      


Glu Gly Ala Glu Thr Val Thr Pro Val Val Asp Pro Ile Gly Tyr Gly 
            100                 105                 110         


Ser Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu Ala Gln Leu Arg 
        115                 120                 125             


Ser Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro Asp Met Val Asp 
    130                 135                 140                 


Tyr Arg Arg Gly Lys Thr Phe Phe Gly Ala Val Met Val Gly Leu Asn 
145                 150                 155                 160 


Pro Glu Leu Pro Ala Ala His Leu Ile Gly Ala Trp Met Ser Gly Gln 
                165                 170                 175     


Gly Leu Ser Trp Glu Ala Ser Gln Glu Glu Ala Phe Leu Arg Ser Gly 
            180                 185                 190         


Ala Gln Phe Ser Pro Thr His Gly Leu Ala Leu Pro Gln Asp Gly Val 
        195                 200                 205             


Tyr Tyr Leu Tyr Cys His Val Gly Tyr Arg Gly Arg Thr Pro Pro Ala 
    210                 215                 220                 


Gly Arg Ser Arg Ala Arg Ser Leu Thr Leu Arg Ser Ala Leu Tyr Arg 
225                 230                 235                 240 


Ala Gly Gly Ala Tyr Gly Arg Gly Ser Pro Glu Leu Leu Leu Glu Gly 
                245                 250                 255     


Ala Glu Thr Val Thr Pro Val Val Asp Pro Ile Gly Tyr Gly Ser Leu 
            260                 265                 270         


Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu Ala Gln Leu Arg Ser Gly 
        275                 280                 285             


Glu Arg Val Tyr Val Asn Ile Ser His Pro Asp Met Val Asp Tyr Arg 
    290                 295                 300                 


Arg Gly Lys Thr Phe Phe Gly Ala Val Met Val Gly Lys Pro Ala Ala 
305                 310                 315                 320 


His Leu Val Gly Tyr Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg Ala 
                325                 330                 335     


Ser Thr Asp Arg Ala Phe Leu Arg His Gly Phe Ser Leu Ser Asn Asn 
            340                 345                 350         


Ser Leu Leu Ile Pro Thr Ser Gly Leu Tyr Phe Val Tyr Ser Gln Val 
        355                 360                 365             


Val Phe Ser Gly Glu Ser Cys Ser Pro Arg Ala Ile Pro Thr Pro Ile 
    370                 375                 380                 


Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe His 
385                 390                 395                 400 


Val Pro Leu Leu Ser Ala Gln Lys Ser Val Tyr Pro Gly Leu Gln Gly 
                405                 410                 415     


Pro Trp Val Arg Ser Met Tyr Gln Gly Ala Val Phe Leu Leu Ser Lys 
            420                 425                 430         


Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Ser His Leu His Phe 
        435                 440                 445             


Ser Pro Ser Ser Val Phe Phe Gly Ala Phe Ala Leu 
    450                 455                 460 


<210>  10
<211>  205
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lymphotoxin-alpha amino acid sequence


<220>
<221>  misc_feature
<222>  (1)..(34)
<223>  predicted signal sequence

<400>  10

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  11
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lymphotoxin-alpha amino acid sequence without predicted signal sequence

<400>  11

Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala Arg Gln 
1               5                   10                  15      


His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala Ala His 
            20                  25                  30          


Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg Ala Asn 
        35                  40                  45              


Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn Asn Ser 
    50                  55                  60                  


Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln Val Val 
65                  70                  75                  80  


Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro Leu Tyr 
                85                  90                  95      


Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe His Val 
            100                 105                 110         


Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln Glu Pro 
        115                 120                 125             


Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr Gln Gly 
    130                 135                 140                 


Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val Leu Ser 
145                 150                 155                 160 


Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
                165                 170     


<210>  12
<211>  144
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lymphotoxin-alpha (aa 62-205)

<400>  12

Lys Pro Ala Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu 
1               5                   10                  15      


Leu Trp Arg Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser 
            20                  25                  30          


Leu Ser Asn Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val 
        35                  40                  45              


Tyr Ser Gln Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr 
    50                  55                  60                  


Ser Ser Pro Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln 
65                  70                  75                  80  


Tyr Pro Phe His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro 
                85                  90                  95      


Gly Leu Gln Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe 
            100                 105                 110         


Gln Leu Thr Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro 
        115                 120                 125             


His Leu Val Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
    130                 135                 140                 


<210>  13
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lymphotoxin-beta amino acid sequence

<400>  13

Met Gly Ala Leu Gly Leu Glu Gly Arg Gly Gly Arg Leu Gln Gly Arg 
1               5                   10                  15      


Gly Ser Leu Leu Leu Ala Val Ala Gly Ala Thr Ser Leu Val Thr Leu 
            20                  25                  30          


Leu Leu Ala Val Pro Ile Thr Val Leu Ala Val Leu Ala Leu Val Pro 
        35                  40                  45              


Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln 
    50                  55                  60                  


Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu 
65                  70                  75                  80  


Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
                85                  90                  95      


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
            100                 105                 110         


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
        115                 120                 125             


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
    130                 135                 140                 


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
145                 150                 155                 160 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
                165                 170                 175     


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
            180                 185                 190         


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
        195                 200                 205             


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
    210                 215                 220                 


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
225                 230                 235                 240 


Val Met Val Gly 
                


<210>  14
<211>  196
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lymphotoxin-beta extracellular domain (aa 49-244)

<400>  14

Gln Asp Gln Gly Gly Leu Val Thr Glu Thr Ala Asp Pro Gly Ala Gln 
1               5                   10                  15      


Ala Gln Gln Gly Leu Gly Phe Gln Lys Leu Pro Glu Glu Glu Pro Glu 
            20                  25                  30          


Thr Asp Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
        35                  40                  45              


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
    50                  55                  60                  


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
65                  70                  75                  80  


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
                85                  90                  95      


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
            100                 105                 110         


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
        115                 120                 125             


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
    130                 135                 140                 


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
145                 150                 155                 160 


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
                165                 170                 175     


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
            180                 185                 190         


Val Met Val Gly 
        195     


<210>  15
<211>  162
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lymphotoxin-beta (aa 83-244)

<400>  15

Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro Leu Lys 
1               5                   10                  15      


Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe Leu Thr 
            20                  25                  30          


Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro Gln Asp 
        35                  40                  45              


Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg Ala Pro 
    50                  55                  60                  


Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg Ser Ser 
65                  70                  75                  80  


Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu Leu Leu 
                85                  90                  95      


Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala Arg Arg 
            100                 105                 110         


Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu 
        115                 120                 125             


Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro 
    130                 135                 140                 


Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala Val Met 
145                 150                 155                 160 


Val Gly 
        


<210>  16
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lymphotoxin  alpha Beta beta single-chain trimer amino acid
       sequence without a signal sequence

<400>  16

Lys Pro Ala Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu 
1               5                   10                  15      


Leu Trp Arg Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser 
            20                  25                  30          


Leu Ser Asn Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val 
        35                  40                  45              


Tyr Ser Gln Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr 
    50                  55                  60                  


Ser Ser Pro Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln 
65                  70                  75                  80  


Tyr Pro Phe His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro 
                85                  90                  95      


Gly Leu Gln Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe 
            100                 105                 110         


Gln Leu Thr Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro 
        115                 120                 125             


His Leu Val Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
    130                 135                 140                 


Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro Leu Lys 
145                 150                 155                 160 


Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe Leu Thr 
                165                 170                 175     


Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro Gln Asp 
            180                 185                 190         


Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg Ala Pro 
        195                 200                 205             


Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg Ser Ser 
    210                 215                 220                 


Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu Leu Leu 
225                 230                 235                 240 


Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala Arg Arg 
                245                 250                 255     


Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu 
            260                 265                 270         


Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro 
        275                 280                 285             


Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala Val Met 
    290                 295                 300                 


Val Gly Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
305                 310                 315                 320 


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
                325                 330                 335     


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
            340                 345                 350         


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
        355                 360                 365             


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
    370                 375                 380                 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
385                 390                 395                 400 


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
                405                 410                 415     


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
            420                 425                 430         


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
        435                 440                 445             


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
    450                 455                 460                 


Val Met Val Gly 
465             


<210>  17
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lymphotoxin beta alpha beta  single-chain trimer amino acid
       sequence without a signal sequence  

<400>  17

Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro Leu Lys 
1               5                   10                  15      


Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe Leu Thr 
            20                  25                  30          


Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro Gln Asp 
        35                  40                  45              


Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg Ala Pro 
    50                  55                  60                  


Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg Ser Ser 
65                  70                  75                  80  


Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu Leu Leu 
                85                  90                  95      


Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala Arg Arg 
            100                 105                 110         


Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu 
        115                 120                 125             


Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro 
    130                 135                 140                 


Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala Val Met 
145                 150                 155                 160 


Val Gly Lys Pro Ala Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn 
                165                 170                 175     


Ser Leu Leu Trp Arg Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly 
            180                 185                 190         


Phe Ser Leu Ser Asn Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr 
        195                 200                 205             


Phe Val Tyr Ser Gln Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys 
    210                 215                 220                 


Ala Thr Ser Ser Pro Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser 
225                 230                 235                 240 


Ser Gln Tyr Pro Phe His Val Pro Leu Leu Ser Ser Gln Lys Met Val 
                245                 250                 255     


Tyr Pro Gly Leu Gln Glu Pro Trp Leu His Ser Met Tyr His Gly Ala 
            260                 265                 270         


Ala Phe Gln Leu Thr Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly 
        275                 280                 285             


Ile Pro His Leu Val Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe 
    290                 295                 300                 


Ala Leu Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
305                 310                 315                 320 


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
                325                 330                 335     


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
            340                 345                 350         


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
        355                 360                 365             


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
    370                 375                 380                 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
385                 390                 395                 400 


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
                405                 410                 415     


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
            420                 425                 430         


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
        435                 440                 445             


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
    450                 455                 460                 


Val Met Val Gly 
465             


<210>  18
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human Lymphotoxin beta beta alpha  single-chain trimer amino acid
       sequence without a signal sequence  

<400>  18

Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro Leu Lys 
1               5                   10                  15      


Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe Leu Thr 
            20                  25                  30          


Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro Gln Asp 
        35                  40                  45              


Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg Ala Pro 
    50                  55                  60                  


Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg Ser Ser 
65                  70                  75                  80  


Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu Leu Leu 
                85                  90                  95      


Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala Arg Arg 
            100                 105                 110         


Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu 
        115                 120                 125             


Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro 
    130                 135                 140                 


Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala Val Met 
145                 150                 155                 160 


Val Gly Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
                165                 170                 175     


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
            180                 185                 190         


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
        195                 200                 205             


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
    210                 215                 220                 


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
225                 230                 235                 240 


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
                245                 250                 255     


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
            260                 265                 270         


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
        275                 280                 285             


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
    290                 295                 300                 


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
305                 310                 315                 320 


Val Met Val Gly Lys Pro Ala Ala His Leu Ile Gly Asp Pro Ser Lys 
                325                 330                 335     


Gln Asn Ser Leu Leu Trp Arg Ala Asn Thr Asp Arg Ala Phe Leu Gln 
            340                 345                 350         


Asp Gly Phe Ser Leu Ser Asn Asn Ser Leu Leu Val Pro Thr Ser Gly 
        355                 360                 365             


Ile Tyr Phe Val Tyr Ser Gln Val Val Phe Ser Gly Lys Ala Tyr Ser 
    370                 375                 380                 


Pro Lys Ala Thr Ser Ser Pro Leu Tyr Leu Ala His Glu Val Gln Leu 
385                 390                 395                 400 


Phe Ser Ser Gln Tyr Pro Phe His Val Pro Leu Leu Ser Ser Gln Lys 
                405                 410                 415     


Met Val Tyr Pro Gly Leu Gln Glu Pro Trp Leu His Ser Met Tyr His 
            420                 425                 430         


Gly Ala Ala Phe Gln Leu Thr Gln Gly Asp Gln Leu Ser Thr His Thr 
        435                 440                 445             


Asp Gly Ile Pro His Leu Val Leu Ser Pro Ser Thr Val Phe Phe Gly 
    450                 455                 460                 


Ala Phe Ala Leu 
465             


<210>  19
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Heavy chain constant region

<400>  19

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  20
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Heavy chain constant region deglycosylated

<400>  20

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  21
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Heavy chain constant region

<400>  21

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  22
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Heavy chain constant region deglycosylated

<400>  22

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  23
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG3 Heavy chain constant region

<400>  23

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  24
<211>  377
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG3 Heavy chain constant region deglycosylated

<400>  24

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Ala Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  25
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 Heavy chain constant region

<400>  25

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  26
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 Heavy chain constant region deglycosylated

<400>  26

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  27
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region

<400>  27

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  28
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region deglycosylated

<400>  28

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  29
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region (13A Version)

<400>  29

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Lys Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  30
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region (13B Version)

<400>  30

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Glu Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Glu Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  31
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region

<400>  31

Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  32
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region deglycosylated

<400>  32

Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Phe Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  33
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region (13A Version)

<400>  33

Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Glu Lys Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Lys 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  34
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region (13B Version)

<400>  34

Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Glu Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Glu Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FLAG Tag

<400>  35

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  36
<211>  900
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  349B1 Anti-B7-H4 deglycosylated mIgG1-mLTalpha beta beta


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  signal sequence

<400>  36

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Ser Lys Ala Leu Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Thr Ile His Pro Gly Thr Gly Gly Thr Ala Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Phe Thr Asn Leu Asp Asn Trp Gly Gln Gly Thr Thr Leu Thr 
        115                 120                 125             


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
    130                 135                 140                 


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
145                 150                 155                 160 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
                165                 170                 175     


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
            180                 185                 190         


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
        195                 200                 205             


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
    210                 215                 220                 


Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys 
225                 230                 235                 240 


Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
                245                 250                 255     


Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp 
        275                 280                 285             


Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe 
    290                 295                 300                 


Ala Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp 
305                 310                 315                 320 


Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe 
                325                 330                 335     


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys 
            340                 345                 350         


Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys 
        355                 360                 365             


Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp 
    370                 375                 380                 


Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys 
385                 390                 395                 400 


Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser 
                405                 410                 415     


Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr 
            420                 425                 430         


Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser 
        435                 440                 445             


Leu Ser His Ser Pro Gly Lys Lys Pro Ala Ala His Leu Val Gly Tyr 
    450                 455                 460                 


Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg Ala Ser Thr Asp Arg Ala 
465                 470                 475                 480 


Phe Leu Arg His Gly Phe Ser Leu Ser Asn Asn Ser Leu Leu Ile Pro 
                485                 490                 495     


Thr Ser Gly Leu Tyr Phe Val Tyr Ser Gln Val Val Phe Ser Gly Glu 
            500                 505                 510         


Ser Cys Ser Pro Arg Ala Ile Pro Thr Pro Ile Tyr Leu Ala His Glu 
        515                 520                 525             


Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe His Val Pro Leu Leu Ser 
    530                 535                 540                 


Ala Gln Lys Ser Val Tyr Pro Gly Leu Gln Gly Pro Trp Val Arg Ser 
545                 550                 555                 560 


Met Tyr Gln Gly Ala Val Phe Leu Leu Ser Lys Gly Asp Gln Leu Ser 
                565                 570                 575     


Thr His Thr Asp Gly Ile Ser His Leu His Phe Ser Pro Ser Ser Val 
            580                 585                 590         


Phe Phe Gly Ala Phe Ala Leu Leu Asn Pro Glu Leu Pro Ala Ala His 
        595                 600                 605             


Leu Ile Gly Ala Trp Met Ser Gly Gln Gly Leu Ser Trp Glu Ala Ser 
    610                 615                 620                 


Gln Glu Glu Ala Phe Leu Arg Ser Gly Ala Gln Phe Ser Pro Thr His 
625                 630                 635                 640 


Gly Leu Ala Leu Pro Gln Asp Gly Val Tyr Tyr Leu Tyr Cys His Val 
                645                 650                 655     


Gly Tyr Arg Gly Arg Thr Pro Pro Ala Gly Arg Ser Arg Ala Arg Ser 
            660                 665                 670         


Leu Thr Leu Arg Ser Ala Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Arg 
        675                 680                 685             


Gly Ser Pro Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val 
    690                 695                 700                 


Val Asp Pro Ile Gly Tyr Gly Ser Leu Trp Tyr Thr Ser Val Gly Phe 
705                 710                 715                 720 


Gly Gly Leu Ala Gln Leu Arg Ser Gly Glu Arg Val Tyr Val Asn Ile 
                725                 730                 735     


Ser His Pro Asp Met Val Asp Tyr Arg Arg Gly Lys Thr Phe Phe Gly 
            740                 745                 750         


Ala Val Met Val Gly Leu Asn Pro Glu Leu Pro Ala Ala His Leu Ile 
        755                 760                 765             


Gly Ala Trp Met Ser Gly Gln Gly Leu Ser Trp Glu Ala Ser Gln Glu 
    770                 775                 780                 


Glu Ala Phe Leu Arg Ser Gly Ala Gln Phe Ser Pro Thr His Gly Leu 
785                 790                 795                 800 


Ala Leu Pro Gln Asp Gly Val Tyr Tyr Leu Tyr Cys His Val Gly Tyr 
                805                 810                 815     


Arg Gly Arg Thr Pro Pro Ala Gly Arg Ser Arg Ala Arg Ser Leu Thr 
            820                 825                 830         


Leu Arg Ser Ala Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Arg Gly Ser 
        835                 840                 845             


Pro Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Val Asp 
    850                 855                 860                 


Pro Ile Gly Tyr Gly Ser Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly 
865                 870                 875                 880 


Leu Ala Gln Leu Arg Ser Gly Glu Arg Val Tyr Val Asn Ile Ser His 
                885                 890                 895     


Pro Asp Met Val 
            900 


<210>  37
<211>  896
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  349B1 Anti-B7-H4 deglycosylated mIgG1-mLTalpha beta beta without signal sequence  

<400>  37

Gln Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Ser Lys Ala Leu Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Thr Ile His Pro Gly Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Phe 
                85                  90                  95      


Thr Asn Leu Asp Asn Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         


Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Ser Ala 
        115                 120                 125             


Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val Lys Gly Tyr 
    130                 135                 140                 


Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser 
145                 150                 155                 160 


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu 
                165                 170                 175     


Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Glu Thr Val 
            180                 185                 190         


Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val Asp Lys Lys 
        195                 200                 205             


Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr Val Pro 
    210                 215                 220                 


Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Val Leu 
225                 230                 235                 240 


Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Ile Ser 
                245                 250                 255     


Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp Asp Val Glu 
            260                 265                 270         


Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe Ala Ser Thr 
        275                 280                 285             


Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp Trp Leu Asn 
    290                 295                 300                 


Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe Pro Ala Pro 
305                 310                 315                 320 


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln 
                325                 330                 335     


Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys Asp Lys Val 
            340                 345                 350         


Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp Ile Thr Val 
        355                 360                 365             


Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln 
    370                 375                 380                 


Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn 
385                 390                 395                 400 


Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr Cys Ser Val 
                405                 410                 415     


Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser Leu Ser His 
            420                 425                 430         


Ser Pro Gly Lys Lys Pro Ala Ala His Leu Val Gly Tyr Pro Ser Lys 
        435                 440                 445             


Gln Asn Ser Leu Leu Trp Arg Ala Ser Thr Asp Arg Ala Phe Leu Arg 
    450                 455                 460                 


His Gly Phe Ser Leu Ser Asn Asn Ser Leu Leu Ile Pro Thr Ser Gly 
465                 470                 475                 480 


Leu Tyr Phe Val Tyr Ser Gln Val Val Phe Ser Gly Glu Ser Cys Ser 
                485                 490                 495     


Pro Arg Ala Ile Pro Thr Pro Ile Tyr Leu Ala His Glu Val Gln Leu 
            500                 505                 510         


Phe Ser Ser Gln Tyr Pro Phe His Val Pro Leu Leu Ser Ala Gln Lys 
        515                 520                 525             


Ser Val Tyr Pro Gly Leu Gln Gly Pro Trp Val Arg Ser Met Tyr Gln 
    530                 535                 540                 


Gly Ala Val Phe Leu Leu Ser Lys Gly Asp Gln Leu Ser Thr His Thr 
545                 550                 555                 560 


Asp Gly Ile Ser His Leu His Phe Ser Pro Ser Ser Val Phe Phe Gly 
                565                 570                 575     


Ala Phe Ala Leu Leu Asn Pro Glu Leu Pro Ala Ala His Leu Ile Gly 
            580                 585                 590         


Ala Trp Met Ser Gly Gln Gly Leu Ser Trp Glu Ala Ser Gln Glu Glu 
        595                 600                 605             


Ala Phe Leu Arg Ser Gly Ala Gln Phe Ser Pro Thr His Gly Leu Ala 
    610                 615                 620                 


Leu Pro Gln Asp Gly Val Tyr Tyr Leu Tyr Cys His Val Gly Tyr Arg 
625                 630                 635                 640 


Gly Arg Thr Pro Pro Ala Gly Arg Ser Arg Ala Arg Ser Leu Thr Leu 
                645                 650                 655     


Arg Ser Ala Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Arg Gly Ser Pro 
            660                 665                 670         


Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Val Asp Pro 
        675                 680                 685             


Ile Gly Tyr Gly Ser Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu 
    690                 695                 700                 


Ala Gln Leu Arg Ser Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro 
705                 710                 715                 720 


Asp Met Val Asp Tyr Arg Arg Gly Lys Thr Phe Phe Gly Ala Val Met 
                725                 730                 735     


Val Gly Leu Asn Pro Glu Leu Pro Ala Ala His Leu Ile Gly Ala Trp 
            740                 745                 750         


Met Ser Gly Gln Gly Leu Ser Trp Glu Ala Ser Gln Glu Glu Ala Phe 
        755                 760                 765             


Leu Arg Ser Gly Ala Gln Phe Ser Pro Thr His Gly Leu Ala Leu Pro 
    770                 775                 780                 


Gln Asp Gly Val Tyr Tyr Leu Tyr Cys His Val Gly Tyr Arg Gly Arg 
785                 790                 795                 800 


Thr Pro Pro Ala Gly Arg Ser Arg Ala Arg Ser Leu Thr Leu Arg Ser 
                805                 810                 815     


Ala Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Arg Gly Ser Pro Glu Leu 
            820                 825                 830         


Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Val Asp Pro Ile Gly 
        835                 840                 845             


Tyr Gly Ser Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu Ala Gln 
    850                 855                 860                 


Leu Arg Ser Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro Asp Met 
865                 870                 875                 880 


Val Asp Tyr Arg Arg Gly Lys Thr Phe Phe Gly Ala Val Met Val Gly 
                885                 890                 895     


<210>  38
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region deglycosylated (13A Version)

<400>  38

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Lys Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  39
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region deglycosylated (13B Version)

<400>  39

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Glu Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Glu Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  40
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region deglycosylated (13A Version)

<400>  40

Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Ala Ser Thr Phe Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Glu Lys Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Lys 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  41
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc region deglycosylated (13B Version)

<400>  41

Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Glu Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Glu Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  42
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1 heavy chain CDR1

<400>  42

Thr Ser Tyr Tyr Met His 
1               5       


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1 heavy chain CDR2

<400>  43

Tyr Val Asp Pro Phe Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1 heavy chain CDR3

<400>  44

Phe Ile Ala Gly Phe Ala Asn 
1               5           


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1 heavy chain CDR3

<400>  45

Ile Ala Gly Phe Ala Asn 
1               5       


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1 light chain CDR1

<400>  46

Lys Ala Ser Gln Asp Ile Lys Ser Tyr Leu Ser 
1               5                   10      


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1 light chain CDR2

<400>  47

Tyr Ala Thr Ser Leu Ala Asp 
1               5           


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1 light chain CDR3

<400>  48

Leu Gln His Gly Glu Ser Pro Tyr Thr 
1               5                   


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1 light chain CDR3

<400>  49

Leu Gln His Gly Glu Ser Pro Tyr 
1               5               


<210>  50
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1 heavy chain variable sequence without signal sequence  

<400>  50

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Asp Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Val 
        35                  40                  45              


Gly Tyr Val Asp Pro Phe Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Ile Ala Gly Phe Ala Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  51
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1 light chain variable sequence without signal sequence  

<400>  51

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  52
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1 heavy chain sequence without signal sequence  

<400>  52

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Asp Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Val 
        35                  40                  45              


Gly Tyr Val Asp Pro Phe Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Gly Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Ile Ala Gly Phe Ala Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys 
    210                 215                 220                 


Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp 
            260                 265                 270         


Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys 
                325                 330                 335     


Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys 
            340                 345                 350         


Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp 
        355                 360                 365             


Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys 
    370                 375                 380                 


Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser 
385                 390                 395                 400 


Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr 
                405                 410                 415     


Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser 
            420                 425                 430         


Leu Ser His Ser Pro Gly Lys 
        435                 


<210>  53
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1 light chain sequence without signal sequence

<400>  53

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Phe Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  54
<211>  458
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1 heavy chain sequence


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  signal sequence

<400>  54

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Asp Tyr Ser Phe 
        35                  40                  45              


Thr Ser Tyr Tyr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Val Gly Tyr Val Asp Pro Phe Asn Gly Gly Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Gly Val 
            100                 105                 110         


Tyr Tyr Cys Ala Phe Ile Ala Gly Phe Ala Asn Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro 
    130                 135                 140                 


Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn 
                165                 170                 175     


Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr 
        195                 200                 205             


Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser 
    210                 215                 220                 


Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro 
225                 230                 235                 240 


Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro 
                245                 250                 255     


Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys 
            260                 265                 270         


Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp 
        275                 280                 285             


Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu 
    290                 295                 300                 


Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met 
305                 310                 315                 320 


His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser 
                325                 330                 335     


Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
            340                 345                 350         


Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln 
        355                 360                 365             


Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe 
    370                 375                 380                 


Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu 
385                 390                 395                 400 


Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe 
                405                 410                 415     


Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn 
            420                 425                 430         


Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr 
        435                 440                 445             


Glu Lys Ser Leu Ser His Ser Pro Gly Lys 
    450                 455             


<210>  55
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1 light chain sequence


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  signal sequence

<400>  55

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser Asp Ile Val Met Thr Gln Ser Pro Ser Ser Met Tyr Ala 
            20                  25                  30          


Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile 
        35                  40                  45              


Lys Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro Lys 
    50                  55                  60                  


Thr Leu Ile Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Gln Asp Phe Ser Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Ser Asp Asp Thr Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu 
            100                 105                 110         


Ser Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
        115                 120                 125             


Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu 
    130                 135                 140                 


Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn 
                165                 170                 175     


Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His 
        195                 200                 205             


Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile 
    210                 215                 220                 


Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230             


<210>  56
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human B7-H4 extracellular domain (aa 1-257 including signal 
       sequence)


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  signal sequence

<400>  56

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys 
    


<210>  57
<211>  2814
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  349B4 humanized anti-B7-H4/ hLTalpha beta beta  heavy chain 
       precursor DNA

<400>  57
atggactgga cctggcggat tctctttctc gtggctgctg ccacaggcgc ccactctcag       60

gtccagctcg tgcagtctgg cgctgaggtg aagaagcctg gggcctccgt gaaggtttcc      120

tgcaaggctt ctggatacac cttcacttcc tactacatgc actgggtgcg ccaggccccc      180

ggacaaaggc tcgaatggat gggatatgtt gatcctttca atggcggaac atcctacaac      240

cagaaattca agggcagagt caccattacc gttgacacat cctctagcac agcctacatg      300

gagctctcca gcctgcggtc tgaagacact gctgtgtatt actgtgcctt tattgctggg      360

tttgctaact ggggccaggg caccctggtc accgtcagct cagccagcac aaagggcccc      420

tccgtgttcc ctctggcccc ttcctccaag tccacctccg gcggcaccgc cgctctgggc      480

tgcctggtga aggactactt ccctgagcct gtgaccgtgt cctggaactc tggcgctctg      540

acctctggcg tccacacctt cccagccgtg ctgcagtcct ccggcctgta ctccctgtcc      600

tccgtggtga ctgtgccttc ctcctccctg ggcacccaga cctacatctg caacgtgaac      660

cacaagcctt ccaacaccaa ggtggacaag cgggtggagc ctaagtcctg cgacaagacc      720

cacacctgcc ctccctgccc tgcccctgag ctgctgggcg gaccttccgt gttcctgttc      780

cctcctaagc ctaaggacac cctgatgatc tcccggaccc ctgaggtgac atgcgtggtg      840

gtggacgtgt cccacgagga ccctgaggtg aagttcaact ggtatgtgga cggcgtggaa      900

gtgcataacg ctaagaccaa gccaagggag gagcagtacg cctccaccta ccgggtggtg      960

tctgtgctga ccgtgctgca ccaggactgg ctgaacggca aagaatacaa gtgcaaggtc     1020

tccaacaagg ccctgcccgc tcccatcgag aaaaccatct ccaaggccaa gggccagcct     1080

cgcgagcctc aggtgtacac cctgccaccc agccgggagg agctgaccaa gaaccaggtg     1140

tccctgacct gtctggtgaa gggcttctac ccttccgata ttgccgtgga gtgggagtct     1200

aacggccagc ccgagaacaa ctacaagacc acccctcctg tgctggactc cgacggctcc     1260

ttcttcctgt actccaagct gaccgtggac aagtcccggt ggcagcaggg caacgtgttc     1320

tcctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgtctctg     1380

tctcctggca aggcccacag caccctcaaa cctgctgctc acctcattgg cgaccccagc     1440

aagcaaaact cactgctctg gcgggcaaac actgaccggg ccttcctcca agatggtttc     1500

tccctctcta acaattctct cctggtcccc acctctggca tctacttcgt ctactcccaa     1560

gtggtcttct ctgggaaagc ctactctccc aaagccacct cctccccact ctacctggcc     1620

catgaggtcc agctcttctc ctcccaatac cccttccatg tgcctctcct ctcttcccaa     1680

aaaatggtgt atccagggct gcaggaaccc tggctgcact ctatgtacca cggggctgct     1740

ttccaactca cccagggaga ccagctctcc acccacactg atggcatccc ccacctcgtc     1800

ctctctcctt ctactgtctt ctttggagcc ttcgctctgc tctcacccgg gctcccagct     1860

gcccacctca tcggcgctcc actgaaaggg caggggctcg gctgggagac tactaaggaa     1920

caggcttttc tgaccagcgg gacccagttc tccgacgccg aggggctggc cctcccccag     1980

gacggcctct attacctcta ctgtctcgtc ggctaccggg gccgcgcccc ccctggcggc     2040

ggggaccccc agggccgctc cgtcaccctg cgctcctctc tgtaccgggc cgggggcgca     2100

tacggccccg gcactcccga gctgctgctc gaaggggccg agaccgtgac tccagtgctg     2160

gaccccgcca ggagacaagg ctacgggcct ctctggtaca ccagcgtggg gttcggcggc     2220

ctggtgcagc tccggagggg cgagagggtg tacgtcaaca tctcccaccc cgatatggtg     2280

gacttcgcca gagggaagac cttctttggg gccgtgatgg tcggactgtc tcctggcctg     2340

cctgccgcac atctgattgg tgcccctctc aaaggacaag gactcggatg ggaaacaaca     2400

aaagaacaag cattcctcac atccggaaca caattttctg atgcagaagg gctcgcactg     2460

ccacaagatg ggctgtacta tctgtattgc ctggttgggt atcgcggtcg cgcacctccc     2520

ggggggggcg atcctcaagg gcggtcagtt accctccgga gcagcctcta tcgggcaggc     2580

ggggcttatg gacctggaac ccctgaactc ctcctggaag gggctgaaac cgtcaccccc     2640

gtcctcgatc ccgctcggcg gcaaggctat ggccccctgt ggtatacctc cgtcggcttt     2700

ggggggctcg tccaactgcg ccggggggaa cgggtctatg tgaatatttc ccatcctgac     2760

atggtcgatt ttgcccgggg caaaacattt ttcggcgctg tcatggtcgg ctga           2814


<210>  58
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  349B4 humanized anti-B7-H4/hLTalpha beta beta  light chain 
       precursor DNA

<400>  58
atggtgctcc agacccaggt cttcatttcc ctgctgctct ggatcagcgg agcctacggg       60

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga cagagtcacc      120

atcacttgca aggcatctca ggacattaaa agctatctca gctggtatca gcagaaacca      180

gggaaagccc ctaagaccct gatctattat gcaacaagcc tcgcagatgg ggtcccatca      240

aggttctctg gctctggatc tgggacagat ttcactctca ccatcagctc tctgcaacct      300

gaagattttg caacttacta ctgtctgcag catggcgaga gcccttacac attcggcgga      360

gggaccaagg tggagatcaa acgcacggtg gctgcaccat ctgtcttcat cttccctcca      420

tctgatgagc agctcaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtcca gtggaaggtg gataacgccc tccaatccgg caactcccag      540

gaatctgtca cagagcagga cagcaaggac agcacctaca gcctcagctc caccctgaca      600

ctgagcaaag cagactacga gaaacacaaa gtctatgcct gcgaagtcac ccatcagggc      660

ctgtcttccc ccgtcacaaa gagcttcaac aggggagagt gctaa                      705


<210>  59
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1-LC2 humanized light chain


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  signal sequence

<400>  59

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Lys Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Gly 
            100                 105                 110         


Glu Ser Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  60
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1-LC2 humanized light chain without signal sequence

<400>  60

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  61
<211>  128
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1-VL2 humanized light chain variable domain


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  signal sequence

<400>  61

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Lys Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Gly 
            100                 105                 110         


Glu Ser Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


<210>  62
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1-VL2 humanized light chain variable domain without signal sequence

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  63
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1_VH2-IgG1 humanized heavy chain


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  signal sequence

<400>  63

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Val Asp Pro Phe Asn Gly Gly Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Phe Ile Ala Gly Phe Ala Asn Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  64
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1_VH2-IgG1 humanized heavy chain without signal sequence

<400>  64

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Val Asp Pro Phe Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Ile Ala Gly Phe Ala Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  65
<211>  134
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1-VH2 humanized heavy chain variable domain


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  signal sequence

<400>  65

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Val Asp Pro Phe Asn Gly Gly Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Phe Ile Ala Gly Phe Ala Asn Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser 
    130                 


<210>  66
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  278M1-VH2 humanized heavy chain variable domain without signal sequence
 
<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Val Asp Pro Phe Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Ile Ala Gly Phe Ala Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120     


<210>  67
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 LC1 humanized light chain


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  signal sequence

<400>  67

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Ile Val Gln Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Gln Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  68
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 LC1 humanized light chain without signal sequence

<400>  68

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Gln Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Gln Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  69
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 LC3 humanized light chain


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  signal sequence

<400>  69

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Ile Val Gln Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Leu Tyr Lys Val Ser Asn Gln Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Ile Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  70
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 LC3 humanized light chain without signal sequence

<400>  70

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Gln Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Leu Tyr Lys Val Ser Asn Gln Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Ile Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  71
<211>  133
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 VL1 light chain variable domain


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  signal sequence

<400>  71

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Ile Val Gln Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Gln Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg 
    130             


<210>  72
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 VL1 light chain variable domain without signal sequence

<400>  72

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Gln Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Gln Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  73
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 LC CDR1

<400>  73

Arg Ser Ser Gln Ser Ile Val Gln Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 LC CDR2

<400>  74

Lys Val Ser Asn Gln Phe Ser 
1               5           


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 LC CDR3

<400>  75

Gln Gly Ser His Val Pro Leu 
1               5           


<210>  76
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36_VH2-IgG1 humanized heavy chain


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  signal sequence

<400>  76

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Thr Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg His Tyr Tyr Gly Ser Asp Trp Tyr Phe Asp Val 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  77
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36_VH2-IgG1 humanized heavy chain without signal sequence

<400>  77

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Tyr Gly Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  78
<211>  139
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 VH2 humanized heavy chain variable domain


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  signal sequence

<400>  78

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Thr Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg His Tyr Tyr Gly Ser Asp Trp Tyr Phe Asp Val 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 


<210>  79
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 VH2 humanized heavy chain variable domain without signal sequence

<400>  79

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Tyr Gly Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser 
        115                 120 


<210>  80
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 VH CDR1

<400>  80

Ser Thr Tyr Gly Met Ser 
1               5       


<210>  81
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 VH CDR2

<400>  81

Ala Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  82
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 VH CDR3

<400>  82

Ala Arg His Tyr Tyr Gly Ser Asp Trp Tyr Phe Asp Val 
1               5                   10              


<210>  83
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human LIGHT with signal sequence


<220>
<221>  misc_feature
<222>  (1)..(58)
<223>  signal sequence

<400>  83

Met Glu Glu Ser Val Val Arg Pro Ser Val Phe Val Val Asp Gly Gln 
1               5                   10                  15      


Thr Asp Ile Pro Phe Thr Arg Leu Gly Arg Ser His Arg Arg Gln Ser 
            20                  25                  30          


Cys Ser Val Ala Arg Val Gly Leu Gly Leu Leu Leu Leu Leu Met Gly 
        35                  40                  45              


Ala Gly Leu Ala Val Gln Gly Trp Phe Leu Leu Gln Leu His Trp Arg 
    50                  55                  60                  


Leu Gly Glu Met Val Thr Arg Leu Pro Asp Gly Pro Ala Gly Ser Trp 
65                  70                  75                  80  


Glu Gln Leu Ile Gln Glu Arg Arg Ser His Glu Val Asn Pro Ala Ala 
                85                  90                  95      


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
            100                 105                 110         


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
        115                 120                 125             


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
    130                 135                 140                 


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
145                 150                 155                 160 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
                165                 170                 175     


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
            180                 185                 190         


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
        195                 200                 205             


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
    210                 215                 220                 


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
225                 230                 235                 240 


<210>  84
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human LIGHT extracellular domain (aa 59-240)

<400>  84

Leu Gln Leu His Trp Arg Leu Gly Glu Met Val Thr Arg Leu Pro Asp 
1               5                   10                  15      


Gly Pro Ala Gly Ser Trp Glu Gln Leu Ile Gln Glu Arg Arg Ser His 
            20                  25                  30          


Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser Leu Thr 
        35                  40                  45              


Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe 
    50                  55                  60                  


Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr Lys Ala 
65                  70                  75                  80  


Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val Gly Cys 
                85                  90                  95      


Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys Arg Thr 
            100                 105                 110         


Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln Ser Pro 
        115                 120                 125             


Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser Ser Phe 
    130                 135                 140                 


Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Lys Val Val Val Arg 
145                 150                 155                 160 


Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr 
                165                 170                 175     


Phe Gly Ala Phe Met Val 
            180         


<210>  85
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human LIGHT fragment (aa 89-240)

<400>  85

Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser 
1               5                   10                  15      


Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu 
            20                  25                  30          


Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr 
        35                  40                  45              


Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val 
    50                  55                  60                  


Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys 
65                  70                  75                  80  


Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln 
                85                  90                  95      


Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser 
            100                 105                 110         


Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Lys Val Val 
        115                 120                 125             


Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg 
    130                 135                 140                 


Ser Tyr Phe Gly Ala Phe Met Val 
145                 150         


<210>  86
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Single gene human LIGHT homotrimer

<400>  86

Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser 
1               5                   10                  15      


Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu 
            20                  25                  30          


Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr 
        35                  40                  45              


Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val 
    50                  55                  60                  


Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys 
65                  70                  75                  80  


Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln 
                85                  90                  95      


Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser 
            100                 105                 110         


Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Lys Val Val 
        115                 120                 125             


Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg 
    130                 135                 140                 


Ser Tyr Phe Gly Ala Phe Met Val Ser His Glu Val Asn Pro Ala Ala 
145                 150                 155                 160 


His Leu Thr Gly Ala Asn Ser Ser Leu Thr Gly Ser Gly Gly Pro Leu 
                165                 170                 175     


Leu Trp Glu Thr Gln Leu Gly Leu Ala Phe Leu Arg Gly Leu Ser Tyr 
            180                 185                 190         


His Asp Gly Ala Leu Val Val Thr Lys Ala Gly Tyr Tyr Tyr Ile Tyr 
        195                 200                 205             


Ser Lys Val Gln Leu Gly Gly Val Gly Cys Pro Leu Gly Leu Ala Ser 
    210                 215                 220                 


Thr Ile Thr His Gly Leu Tyr Lys Arg Thr Pro Arg Tyr Pro Glu Glu 
225                 230                 235                 240 


Leu Glu Leu Leu Val Ser Gln Gln Ser Pro Cys Gly Arg Ala Thr Ser 
                245                 250                 255     


Ser Ser Arg Val Trp Trp Asp Ser Ser Phe Leu Gly Gly Val Val His 
            260                 265                 270         


Leu Glu Ala Gly Glu Lys Val Val Val Arg Val Leu Asp Glu Arg Leu 
        275                 280                 285             


Val Arg Leu Arg Asp Gly Thr Arg Ser Tyr Phe Gly Ala Phe Met Val 
    290                 295                 300                 


Ser His Glu Val Asn Pro Ala Ala His Leu Thr Gly Ala Asn Ser Ser 
305                 310                 315                 320 


Leu Thr Gly Ser Gly Gly Pro Leu Leu Trp Glu Thr Gln Leu Gly Leu 
                325                 330                 335     


Ala Phe Leu Arg Gly Leu Ser Tyr His Asp Gly Ala Leu Val Val Thr 
            340                 345                 350         


Lys Ala Gly Tyr Tyr Tyr Ile Tyr Ser Lys Val Gln Leu Gly Gly Val 
        355                 360                 365             


Gly Cys Pro Leu Gly Leu Ala Ser Thr Ile Thr His Gly Leu Tyr Lys 
    370                 375                 380                 


Arg Thr Pro Arg Tyr Pro Glu Glu Leu Glu Leu Leu Val Ser Gln Gln 
385                 390                 395                 400 


Ser Pro Cys Gly Arg Ala Thr Ser Ser Ser Arg Val Trp Trp Asp Ser 
                405                 410                 415     


Ser Phe Leu Gly Gly Val Val His Leu Glu Ala Gly Glu Lys Val Val 
            420                 425                 430         


Val Arg Val Leu Asp Glu Arg Leu Val Arg Leu Arg Asp Gly Thr Arg 
        435                 440                 445             


Ser Tyr Phe Gly Ala Phe Met Val 
    450                 455     


<210>  87
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human B7-H4 with signal sequence


<220>
<221>  misc_feature
<222>  (1)..(29)
<223>  signal sequence

<400>  87

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  88
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human B7-H4 extracellular domain without signal sequence

<400>  88

Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala 
1               5                   10                  15      


Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp 
            20                  25                  30          


Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu 
        35                  40                  45              


Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln 
    50                  55                  60                  


Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile 
65                  70                  75                  80  


Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala 
                85                  90                  95      


Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala 
            100                 105                 110         


Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val 
        115                 120                 125             


Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp 
    130                 135                 140                 


Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala 
145                 150                 155                 160 


Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn 
                165                 170                 175     


Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn 
            180                 185                 190         


Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp 
        195                 200                 205             


Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu 
    210                 215                 220                 


Leu Asn Ser Lys 
225             


<210>  89
<211>  829
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CDH3


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  signal sequence

<400>  89

Met Gly Leu Pro Arg Gly Pro Leu Ala Ser Leu Leu Leu Leu Gln Val 
1               5                   10                  15      


Cys Trp Leu Gln Cys Ala Ala Ser Glu Pro Cys Arg Ala Val Phe Arg 
            20                  25                  30          


Glu Ala Glu Val Thr Leu Glu Ala Gly Gly Ala Glu Gln Glu Pro Gly 
        35                  40                  45              


Gln Ala Leu Gly Lys Val Phe Met Gly Cys Pro Gly Gln Glu Pro Ala 
    50                  55                  60                  


Leu Phe Ser Thr Asp Asn Asp Asp Phe Thr Val Arg Asn Gly Glu Thr 
65                  70                  75                  80  


Val Gln Glu Arg Arg Ser Leu Lys Glu Arg Asn Pro Leu Lys Ile Phe 
                85                  90                  95      


Pro Ser Lys Arg Ile Leu Arg Arg His Lys Arg Asp Trp Val Val Ala 
            100                 105                 110         


Pro Ile Ser Val Pro Glu Asn Gly Lys Gly Pro Phe Pro Gln Arg Leu 
        115                 120                 125             


Asn Gln Leu Lys Ser Asn Lys Asp Arg Asp Thr Lys Ile Phe Tyr Ser 
    130                 135                 140                 


Ile Thr Gly Pro Gly Ala Asp Ser Pro Pro Glu Gly Val Phe Ala Val 
145                 150                 155                 160 


Glu Lys Glu Thr Gly Trp Leu Leu Leu Asn Lys Pro Leu Asp Arg Glu 
                165                 170                 175     


Glu Ile Ala Lys Tyr Glu Leu Phe Gly His Ala Val Ser Glu Asn Gly 
            180                 185                 190         


Ala Ser Val Glu Asp Pro Met Asn Ile Ser Ile Ile Val Thr Asp Gln 
        195                 200                 205             


Asn Asp His Lys Pro Lys Phe Thr Gln Asp Thr Phe Arg Gly Ser Val 
    210                 215                 220                 


Leu Glu Gly Val Leu Pro Gly Thr Ser Val Met Gln Val Thr Ala Thr 
225                 230                 235                 240 


Asp Glu Asp Asp Ala Ile Tyr Thr Tyr Asn Gly Val Val Ala Tyr Ser 
                245                 250                 255     


Ile His Ser Gln Glu Pro Lys Asp Pro His Asp Leu Met Phe Thr Ile 
            260                 265                 270         


His Arg Ser Thr Gly Thr Ile Ser Val Ile Ser Ser Gly Leu Asp Arg 
        275                 280                 285             


Glu Lys Val Pro Glu Tyr Thr Leu Thr Ile Gln Ala Thr Asp Met Asp 
    290                 295                 300                 


Gly Asp Gly Ser Thr Thr Thr Ala Val Ala Val Val Glu Ile Leu Asp 
305                 310                 315                 320 


Ala Asn Asp Asn Ala Pro Met Phe Asp Pro Gln Lys Tyr Glu Ala His 
                325                 330                 335     


Val Pro Glu Asn Ala Val Gly His Glu Val Gln Arg Leu Thr Val Thr 
            340                 345                 350         


Asp Leu Asp Ala Pro Asn Ser Pro Ala Trp Arg Ala Thr Tyr Leu Ile 
        355                 360                 365             


Met Gly Gly Asp Asp Gly Asp His Phe Thr Ile Thr Thr His Pro Glu 
    370                 375                 380                 


Ser Asn Gln Gly Ile Leu Thr Thr Arg Lys Gly Leu Asp Phe Glu Ala 
385                 390                 395                 400 


Lys Asn Gln His Thr Leu Tyr Val Glu Val Thr Asn Glu Ala Pro Phe 
                405                 410                 415     


Val Leu Lys Leu Pro Thr Ser Thr Ala Thr Ile Val Val His Val Glu 
            420                 425                 430         


Asp Val Asn Glu Ala Pro Val Phe Val Pro Pro Ser Lys Val Val Glu 
        435                 440                 445             


Val Gln Glu Gly Ile Pro Thr Gly Glu Pro Val Cys Val Tyr Thr Ala 
    450                 455                 460                 


Glu Asp Pro Asp Lys Glu Asn Gln Lys Ile Ser Tyr Arg Ile Leu Arg 
465                 470                 475                 480 


Asp Pro Ala Gly Trp Leu Ala Met Asp Pro Asp Ser Gly Gln Val Thr 
                485                 490                 495     


Ala Val Gly Thr Leu Asp Arg Glu Asp Glu Gln Phe Val Arg Asn Asn 
            500                 505                 510         


Ile Tyr Glu Val Met Val Leu Ala Met Asp Asn Gly Ser Pro Pro Thr 
        515                 520                 525             


Thr Gly Thr Gly Thr Leu Leu Leu Thr Leu Ile Asp Val Asn Asp His 
    530                 535                 540                 


Gly Pro Val Pro Glu Pro Arg Gln Ile Thr Ile Cys Asn Gln Ser Pro 
545                 550                 555                 560 


Val Arg Gln Val Leu Asn Ile Thr Asp Lys Asp Leu Ser Pro His Thr 
                565                 570                 575     


Ser Pro Phe Gln Ala Gln Leu Thr Asp Asp Ser Asp Ile Tyr Trp Thr 
            580                 585                 590         


Ala Glu Val Asn Glu Glu Gly Asp Thr Val Val Leu Ser Leu Lys Lys 
        595                 600                 605             


Phe Leu Lys Gln Asp Thr Tyr Asp Val His Leu Ser Leu Ser Asp His 
    610                 615                 620                 


Gly Asn Lys Glu Gln Leu Thr Val Ile Arg Ala Thr Val Cys Asp Cys 
625                 630                 635                 640 


His Gly His Val Glu Thr Cys Pro Gly Pro Trp Lys Gly Gly Phe Ile 
                645                 650                 655     


Leu Pro Val Leu Gly Ala Val Leu Ala Leu Leu Phe Leu Leu Leu Val 
            660                 665                 670         


Leu Leu Leu Leu Val Arg Lys Lys Arg Lys Ile Lys Glu Pro Leu Leu 
        675                 680                 685             


Leu Pro Glu Asp Asp Thr Arg Asp Asn Val Phe Tyr Tyr Gly Glu Glu 
    690                 695                 700                 


Gly Gly Gly Glu Glu Asp Gln Asp Tyr Asp Ile Thr Gln Leu His Arg 
705                 710                 715                 720 


Gly Leu Glu Ala Arg Pro Glu Val Val Leu Arg Asn Asp Val Ala Pro 
                725                 730                 735     


Thr Ile Ile Pro Thr Pro Met Tyr Arg Pro Arg Pro Ala Asn Pro Asp 
            740                 745                 750         


Glu Ile Gly Asn Phe Ile Ile Glu Asn Leu Lys Ala Ala Asn Thr Asp 
        755                 760                 765             


Pro Thr Ala Pro Pro Tyr Asp Thr Leu Leu Val Phe Asp Tyr Glu Gly 
    770                 775                 780                 


Ser Gly Ser Asp Ala Ala Ser Leu Ser Ser Leu Thr Ser Ser Ala Ser 
785                 790                 795                 800 


Asp Gln Asp Gln Asp Tyr Asp Tyr Leu Asn Glu Trp Gly Ser Arg Phe 
                805                 810                 815     


Lys Lys Leu Ala Asp Met Tyr Gly Gly Gly Glu Asp Asp 
            820                 825                 


<210>  90
<211>  653
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human CDH3 extracellular domain


<220>
<221>  misc_feature
<222>  (1)..(24)
<223>  signal sequence

<400>  90

Met Gly Leu Pro Arg Gly Pro Leu Ala Ser Leu Leu Leu Leu Gln Val 
1               5                   10                  15      


Cys Trp Leu Gln Cys Ala Ala Ser Glu Pro Cys Arg Ala Val Phe Arg 
            20                  25                  30          


Glu Ala Glu Val Thr Leu Glu Ala Gly Gly Ala Glu Gln Glu Pro Gly 
        35                  40                  45              


Gln Ala Leu Gly Lys Val Phe Met Gly Cys Pro Gly Gln Glu Pro Ala 
    50                  55                  60                  


Leu Phe Ser Thr Asp Asn Asp Asp Phe Thr Val Arg Asn Gly Glu Thr 
65                  70                  75                  80  


Val Gln Glu Arg Arg Ser Leu Lys Glu Arg Asn Pro Leu Lys Ile Phe 
                85                  90                  95      


Pro Ser Lys Arg Ile Leu Arg Arg His Lys Arg Asp Trp Val Val Ala 
            100                 105                 110         


Pro Ile Ser Val Pro Glu Asn Gly Lys Gly Pro Phe Pro Gln Arg Leu 
        115                 120                 125             


Asn Gln Leu Lys Ser Asn Lys Asp Arg Asp Thr Lys Ile Phe Tyr Ser 
    130                 135                 140                 


Ile Thr Gly Pro Gly Ala Asp Ser Pro Pro Glu Gly Val Phe Ala Val 
145                 150                 155                 160 


Glu Lys Glu Thr Gly Trp Leu Leu Leu Asn Lys Pro Leu Asp Arg Glu 
                165                 170                 175     


Glu Ile Ala Lys Tyr Glu Leu Phe Gly His Ala Val Ser Glu Asn Gly 
            180                 185                 190         


Ala Ser Val Glu Asp Pro Met Asn Ile Ser Ile Ile Val Thr Asp Gln 
        195                 200                 205             


Asn Asp His Lys Pro Lys Phe Thr Gln Asp Thr Phe Arg Gly Ser Val 
    210                 215                 220                 


Leu Glu Gly Val Leu Pro Gly Thr Ser Val Met Gln Val Thr Ala Thr 
225                 230                 235                 240 


Asp Glu Asp Asp Ala Ile Tyr Thr Tyr Asn Gly Val Val Ala Tyr Ser 
                245                 250                 255     


Ile His Ser Gln Glu Pro Lys Asp Pro His Asp Leu Met Phe Thr Ile 
            260                 265                 270         


His Arg Ser Thr Gly Thr Ile Ser Val Ile Ser Ser Gly Leu Asp Arg 
        275                 280                 285             


Glu Lys Val Pro Glu Tyr Thr Leu Thr Ile Gln Ala Thr Asp Met Asp 
    290                 295                 300                 


Gly Asp Gly Ser Thr Thr Thr Ala Val Ala Val Val Glu Ile Leu Asp 
305                 310                 315                 320 


Ala Asn Asp Asn Ala Pro Met Phe Asp Pro Gln Lys Tyr Glu Ala His 
                325                 330                 335     


Val Pro Glu Asn Ala Val Gly His Glu Val Gln Arg Leu Thr Val Thr 
            340                 345                 350         


Asp Leu Asp Ala Pro Asn Ser Pro Ala Trp Arg Ala Thr Tyr Leu Ile 
        355                 360                 365             


Met Gly Gly Asp Asp Gly Asp His Phe Thr Ile Thr Thr His Pro Glu 
    370                 375                 380                 


Ser Asn Gln Gly Ile Leu Thr Thr Arg Lys Gly Leu Asp Phe Glu Ala 
385                 390                 395                 400 


Lys Asn Gln His Thr Leu Tyr Val Glu Val Thr Asn Glu Ala Pro Phe 
                405                 410                 415     


Val Leu Lys Leu Pro Thr Ser Thr Ala Thr Ile Val Val His Val Glu 
            420                 425                 430         


Asp Val Asn Glu Ala Pro Val Phe Val Pro Pro Ser Lys Val Val Glu 
        435                 440                 445             


Val Gln Glu Gly Ile Pro Thr Gly Glu Pro Val Cys Val Tyr Thr Ala 
    450                 455                 460                 


Glu Asp Pro Asp Lys Glu Asn Gln Lys Ile Ser Tyr Arg Ile Leu Arg 
465                 470                 475                 480 


Asp Pro Ala Gly Trp Leu Ala Met Asp Pro Asp Ser Gly Gln Val Thr 
                485                 490                 495     


Ala Val Gly Thr Leu Asp Arg Glu Asp Glu Gln Phe Val Arg Asn Asn 
            500                 505                 510         


Ile Tyr Glu Val Met Val Leu Ala Met Asp Asn Gly Ser Pro Pro Thr 
        515                 520                 525             


Thr Gly Thr Gly Thr Leu Leu Leu Thr Leu Ile Asp Val Asn Asp His 
    530                 535                 540                 


Gly Pro Val Pro Glu Pro Arg Gln Ile Thr Ile Cys Asn Gln Ser Pro 
545                 550                 555                 560 


Val Arg Gln Val Leu Asn Ile Thr Asp Lys Asp Leu Ser Pro His Thr 
                565                 570                 575     


Ser Pro Phe Gln Ala Gln Leu Thr Asp Asp Ser Asp Ile Tyr Trp Thr 
            580                 585                 590         


Ala Glu Val Asn Glu Glu Gly Asp Thr Val Val Leu Ser Leu Lys Lys 
        595                 600                 605             


Phe Leu Lys Gln Asp Thr Tyr Asp Val His Leu Ser Leu Ser Asp His 
    610                 615                 620                 


Gly Asn Lys Glu Gln Leu Thr Val Ile Arg Ala Thr Val Cys Asp Cys 
625                 630                 635                 640 


His Gly His Val Glu Thr Cys Pro Gly Pro Trp Lys Gly 
                645                 650             


<210>  91
<211>  546
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature human CDH3 extracellular domain

<400>  91

Asp Trp Val Val Ala Pro Ile Ser Val Pro Glu Asn Gly Lys Gly Pro 
1               5                   10                  15      


Phe Pro Gln Arg Leu Asn Gln Leu Lys Ser Asn Lys Asp Arg Asp Thr 
            20                  25                  30          


Lys Ile Phe Tyr Ser Ile Thr Gly Pro Gly Ala Asp Ser Pro Pro Glu 
        35                  40                  45              


Gly Val Phe Ala Val Glu Lys Glu Thr Gly Trp Leu Leu Leu Asn Lys 
    50                  55                  60                  


Pro Leu Asp Arg Glu Glu Ile Ala Lys Tyr Glu Leu Phe Gly His Ala 
65                  70                  75                  80  


Val Ser Glu Asn Gly Ala Ser Val Glu Asp Pro Met Asn Ile Ser Ile 
                85                  90                  95      


Ile Val Thr Asp Gln Asn Asp His Lys Pro Lys Phe Thr Gln Asp Thr 
            100                 105                 110         


Phe Arg Gly Ser Val Leu Glu Gly Val Leu Pro Gly Thr Ser Val Met 
        115                 120                 125             


Gln Val Thr Ala Thr Asp Glu Asp Asp Ala Ile Tyr Thr Tyr Asn Gly 
    130                 135                 140                 


Val Val Ala Tyr Ser Ile His Ser Gln Glu Pro Lys Asp Pro His Asp 
145                 150                 155                 160 


Leu Met Phe Thr Ile His Arg Ser Thr Gly Thr Ile Ser Val Ile Ser 
                165                 170                 175     


Ser Gly Leu Asp Arg Glu Lys Val Pro Glu Tyr Thr Leu Thr Ile Gln 
            180                 185                 190         


Ala Thr Asp Met Asp Gly Asp Gly Ser Thr Thr Thr Ala Val Ala Val 
        195                 200                 205             


Val Glu Ile Leu Asp Ala Asn Asp Asn Ala Pro Met Phe Asp Pro Gln 
    210                 215                 220                 


Lys Tyr Glu Ala His Val Pro Glu Asn Ala Val Gly His Glu Val Gln 
225                 230                 235                 240 


Arg Leu Thr Val Thr Asp Leu Asp Ala Pro Asn Ser Pro Ala Trp Arg 
                245                 250                 255     


Ala Thr Tyr Leu Ile Met Gly Gly Asp Asp Gly Asp His Phe Thr Ile 
            260                 265                 270         


Thr Thr His Pro Glu Ser Asn Gln Gly Ile Leu Thr Thr Arg Lys Gly 
        275                 280                 285             


Leu Asp Phe Glu Ala Lys Asn Gln His Thr Leu Tyr Val Glu Val Thr 
    290                 295                 300                 


Asn Glu Ala Pro Phe Val Leu Lys Leu Pro Thr Ser Thr Ala Thr Ile 
305                 310                 315                 320 


Val Val His Val Glu Asp Val Asn Glu Ala Pro Val Phe Val Pro Pro 
                325                 330                 335     


Ser Lys Val Val Glu Val Gln Glu Gly Ile Pro Thr Gly Glu Pro Val 
            340                 345                 350         


Cys Val Tyr Thr Ala Glu Asp Pro Asp Lys Glu Asn Gln Lys Ile Ser 
        355                 360                 365             


Tyr Arg Ile Leu Arg Asp Pro Ala Gly Trp Leu Ala Met Asp Pro Asp 
    370                 375                 380                 


Ser Gly Gln Val Thr Ala Val Gly Thr Leu Asp Arg Glu Asp Glu Gln 
385                 390                 395                 400 


Phe Val Arg Asn Asn Ile Tyr Glu Val Met Val Leu Ala Met Asp Asn 
                405                 410                 415     


Gly Ser Pro Pro Thr Thr Gly Thr Gly Thr Leu Leu Leu Thr Leu Ile 
            420                 425                 430         


Asp Val Asn Asp His Gly Pro Val Pro Glu Pro Arg Gln Ile Thr Ile 
        435                 440                 445             


Cys Asn Gln Ser Pro Val Arg Gln Val Leu Asn Ile Thr Asp Lys Asp 
    450                 455                 460                 


Leu Ser Pro His Thr Ser Pro Phe Gln Ala Gln Leu Thr Asp Asp Ser 
465                 470                 475                 480 


Asp Ile Tyr Trp Thr Ala Glu Val Asn Glu Glu Gly Asp Thr Val Val 
                485                 490                 495     


Leu Ser Leu Lys Lys Phe Leu Lys Gln Asp Thr Tyr Asp Val His Leu 
            500                 505                 510         


Ser Leu Ser Asp His Gly Asn Lys Glu Gln Leu Thr Val Ile Arg Ala 
        515                 520                 525             


Thr Val Cys Asp Cys His Gly His Val Glu Thr Cys Pro Gly Pro Trp 
    530                 535                 540                 


Lys Gly 
545     


<210>  92
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 VL3 light chain variable domain


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  signal sequence

<400>  92

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Pro Val 
            20                  25                  30          


Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile 
        35                  40                  45              


Val Gln Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Gln Leu Leu Leu Tyr Lys Val Ser Asn Gln Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Ile Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Arg 
    130         


<210>  93
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  173M36 VL3 light chain variable domain without signal sequence

<400>  93

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Gln Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Leu Tyr Lys Val Ser Asn Gln Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Ile Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  94
<211>  682
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  363F1 mFc-mLTalpha beta beta

<400>  94

Gly Cys Lys Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe 
1               5                   10                  15      


Ile Phe Pro Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro 
            20                  25                  30          


Lys Val Thr Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Ser Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr 
    50                  55                  60                  


Gln Pro Arg Glu Glu Gln Phe Ala Ser Thr Phe Arg Ser Val Ser Glu 
65                  70                  75                  80  


Leu Pro Ile Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys 
                85                  90                  95      


Arg Val Asn Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Thr Lys Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro 
        115                 120                 125             


Pro Lys Glu Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile 
    130                 135                 140                 


Thr Asp Phe Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly 
145                 150                 155                 160 


Gln Pro Ala Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp 
                165                 170                 175     


Gly Ser Tyr Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp 
            180                 185                 190         


Glu Ala Gly Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His 
        195                 200                 205             


Asn His His Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys Lys Pro 
    210                 215                 220                 


Ala Ala His Leu Val Gly Tyr Pro Ser Lys Gln Asn Ser Leu Leu Trp 
225                 230                 235                 240 


Arg Ala Ser Thr Asp Arg Ala Phe Leu Arg His Gly Phe Ser Leu Ser 
                245                 250                 255     


Asn Asn Ser Leu Leu Ile Pro Thr Ser Gly Leu Tyr Phe Val Tyr Ser 
            260                 265                 270         


Gln Val Val Phe Ser Gly Glu Ser Cys Ser Pro Arg Ala Ile Pro Thr 
        275                 280                 285             


Pro Ile Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro 
    290                 295                 300                 


Phe His Val Pro Leu Leu Ser Ala Gln Lys Ser Val Tyr Pro Gly Leu 
305                 310                 315                 320 


Gln Gly Pro Trp Val Arg Ser Met Tyr Gln Gly Ala Val Phe Leu Leu 
                325                 330                 335     


Ser Lys Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Ser His Leu 
            340                 345                 350         


His Phe Ser Pro Ser Ser Val Phe Phe Gly Ala Phe Ala Leu Leu Asn 
        355                 360                 365             


Pro Glu Leu Pro Ala Ala His Leu Ile Gly Ala Trp Met Ser Gly Gln 
    370                 375                 380                 


Gly Leu Ser Trp Glu Ala Ser Gln Glu Glu Ala Phe Leu Arg Ser Gly 
385                 390                 395                 400 


Ala Gln Phe Ser Pro Thr His Gly Leu Ala Leu Pro Gln Asp Gly Val 
                405                 410                 415     


Tyr Tyr Leu Tyr Cys His Val Gly Tyr Arg Gly Arg Thr Pro Pro Ala 
            420                 425                 430         


Gly Arg Ser Arg Ala Arg Ser Leu Thr Leu Arg Ser Ala Leu Tyr Arg 
        435                 440                 445             


Ala Gly Gly Ala Tyr Gly Arg Gly Ser Pro Glu Leu Leu Leu Glu Gly 
    450                 455                 460                 


Ala Glu Thr Val Thr Pro Val Val Asp Pro Ile Gly Tyr Gly Ser Leu 
465                 470                 475                 480 


Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu Ala Gln Leu Arg Ser Gly 
                485                 490                 495     


Glu Arg Val Tyr Val Asn Ile Ser His Pro Asp Met Val Asp Tyr Arg 
            500                 505                 510         


Arg Gly Lys Thr Phe Phe Gly Ala Val Met Val Gly Leu Asn Pro Glu 
        515                 520                 525             


Leu Pro Ala Ala His Leu Ile Gly Ala Trp Met Ser Gly Gln Gly Leu 
    530                 535                 540                 


Ser Trp Glu Ala Ser Gln Glu Glu Ala Phe Leu Arg Ser Gly Ala Gln 
545                 550                 555                 560 


Phe Ser Pro Thr His Gly Leu Ala Leu Pro Gln Asp Gly Val Tyr Tyr 
                565                 570                 575     


Leu Tyr Cys His Val Gly Tyr Arg Gly Arg Thr Pro Pro Ala Gly Arg 
            580                 585                 590         


Ser Arg Ala Arg Ser Leu Thr Leu Arg Ser Ala Leu Tyr Arg Ala Gly 
        595                 600                 605             


Gly Ala Tyr Gly Arg Gly Ser Pro Glu Leu Leu Leu Glu Gly Ala Glu 
    610                 615                 620                 


Thr Val Thr Pro Val Val Asp Pro Ile Gly Tyr Gly Ser Leu Trp Tyr 
625                 630                 635                 640 


Thr Ser Val Gly Phe Gly Gly Leu Ala Gln Leu Arg Ser Gly Glu Arg 
                645                 650                 655     


Val Tyr Val Asn Ile Ser His Pro Asp Met Val Asp Tyr Arg Arg Gly 
            660                 665                 670         


Lys Thr Phe Phe Gly Ala Val Met Val Gly 
        675                 680         


<210>  95
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  363F2 hFc-hLTalpha beta beta

<400>  95

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Lys Pro Ala Ala His Leu Ile Gly Asp Pro Ser Lys Gln 
225                 230                 235                 240 


Asn Ser Leu Leu Trp Arg Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp 
                245                 250                 255     


Gly Phe Ser Leu Ser Asn Asn Ser Leu Leu Val Pro Thr Ser Gly Ile 
            260                 265                 270         


Tyr Phe Val Tyr Ser Gln Val Val Phe Ser Gly Lys Ala Tyr Ser Pro 
        275                 280                 285             


Lys Ala Thr Ser Ser Pro Leu Tyr Leu Ala His Glu Val Gln Leu Phe 
    290                 295                 300                 


Ser Ser Gln Tyr Pro Phe His Val Pro Leu Leu Ser Ser Gln Lys Met 
305                 310                 315                 320 


Val Tyr Pro Gly Leu Gln Glu Pro Trp Leu His Ser Met Tyr His Gly 
                325                 330                 335     


Ala Ala Phe Gln Leu Thr Gln Gly Asp Gln Leu Ser Thr His Thr Asp 
            340                 345                 350         


Gly Ile Pro His Leu Val Leu Ser Pro Ser Thr Val Phe Phe Gly Ala 
        355                 360                 365             


Phe Ala Leu Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala 
    370                 375                 380                 


Pro Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala 
385                 390                 395                 400 


Phe Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu 
                405                 410                 415     


Pro Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly 
            420                 425                 430         


Arg Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu 
        435                 440                 445             


Arg Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro 
    450                 455                 460                 


Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro 
465                 470                 475                 480 


Ala Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe 
                485                 490                 495     


Gly Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile 
            500                 505                 510         


Ser His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly 
        515                 520                 525             


Ala Val Met Val Gly Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile 
    530                 535                 540                 


Gly Ala Pro Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu 
545                 550                 555                 560 


Gln Ala Phe Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu 
                565                 570                 575     


Ala Leu Pro Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr 
            580                 585                 590         


Arg Gly Arg Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val 
        595                 600                 605             


Thr Leu Arg Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly 
    610                 615                 620                 


Thr Pro Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu 
625                 630                 635                 640 


Asp Pro Ala Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val 
                645                 650                 655     


Gly Phe Gly Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val 
            660                 665                 670         


Asn Ile Ser His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe 
        675                 680                 685             


Phe Gly Ala Val Met Val Gly 
    690                 695 


<210>  96
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  363F3 hFc-hLTbeta alpha beta

<400>  96

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala 
225                 230                 235                 240 


Pro Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala 
                245                 250                 255     


Phe Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu 
            260                 265                 270         


Pro Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly 
        275                 280                 285             


Arg Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu 
    290                 295                 300                 


Arg Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro 
305                 310                 315                 320 


Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro 
                325                 330                 335     


Ala Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe 
            340                 345                 350         


Gly Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile 
        355                 360                 365             


Ser His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly 
    370                 375                 380                 


Ala Val Met Val Gly Lys Pro Ala Ala His Leu Ile Gly Asp Pro Ser 
385                 390                 395                 400 


Lys Gln Asn Ser Leu Leu Trp Arg Ala Asn Thr Asp Arg Ala Phe Leu 
                405                 410                 415     


Gln Asp Gly Phe Ser Leu Ser Asn Asn Ser Leu Leu Val Pro Thr Ser 
            420                 425                 430         


Gly Ile Tyr Phe Val Tyr Ser Gln Val Val Phe Ser Gly Lys Ala Tyr 
        435                 440                 445             


Ser Pro Lys Ala Thr Ser Ser Pro Leu Tyr Leu Ala His Glu Val Gln 
    450                 455                 460                 


Leu Phe Ser Ser Gln Tyr Pro Phe His Val Pro Leu Leu Ser Ser Gln 
465                 470                 475                 480 


Lys Met Val Tyr Pro Gly Leu Gln Glu Pro Trp Leu His Ser Met Tyr 
                485                 490                 495     


His Gly Ala Ala Phe Gln Leu Thr Gln Gly Asp Gln Leu Ser Thr His 
            500                 505                 510         


Thr Asp Gly Ile Pro His Leu Val Leu Ser Pro Ser Thr Val Phe Phe 
        515                 520                 525             


Gly Ala Phe Ala Leu Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile 
    530                 535                 540                 


Gly Ala Pro Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu 
545                 550                 555                 560 


Gln Ala Phe Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu 
                565                 570                 575     


Ala Leu Pro Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr 
            580                 585                 590         


Arg Gly Arg Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val 
        595                 600                 605             


Thr Leu Arg Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly 
    610                 615                 620                 


Thr Pro Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu 
625                 630                 635                 640 


Asp Pro Ala Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val 
                645                 650                 655     


Gly Phe Gly Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val 
            660                 665                 670         


Asn Ile Ser His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe 
        675                 680                 685             


Phe Gly Ala Val Met Val Gly 
    690                 695 


<210>  97
<211>  695
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  363F4 hFc-hLTbeta beta alpha

<400>  97

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala 
225                 230                 235                 240 


Pro Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala 
                245                 250                 255     


Phe Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu 
            260                 265                 270         


Pro Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly 
        275                 280                 285             


Arg Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu 
    290                 295                 300                 


Arg Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro 
305                 310                 315                 320 


Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro 
                325                 330                 335     


Ala Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe 
            340                 345                 350         


Gly Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile 
        355                 360                 365             


Ser His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly 
    370                 375                 380                 


Ala Val Met Val Gly Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile 
385                 390                 395                 400 


Gly Ala Pro Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu 
                405                 410                 415     


Gln Ala Phe Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu 
            420                 425                 430         


Ala Leu Pro Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr 
        435                 440                 445             


Arg Gly Arg Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val 
    450                 455                 460                 


Thr Leu Arg Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly 
465                 470                 475                 480 


Thr Pro Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu 
                485                 490                 495     


Asp Pro Ala Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val 
            500                 505                 510         


Gly Phe Gly Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val 
        515                 520                 525             


Asn Ile Ser His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe 
    530                 535                 540                 


Phe Gly Ala Val Met Val Gly Lys Pro Ala Ala His Leu Ile Gly Asp 
545                 550                 555                 560 


Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg Ala Asn Thr Asp Arg Ala 
                565                 570                 575     


Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn Asn Ser Leu Leu Val Pro 
            580                 585                 590         


Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln Val Val Phe Ser Gly Lys 
        595                 600                 605             


Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro Leu Tyr Leu Ala His Glu 
    610                 615                 620                 


Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe His Val Pro Leu Leu Ser 
625                 630                 635                 640 


Ser Gln Lys Met Val Tyr Pro Gly Leu Gln Glu Pro Trp Leu His Ser 
                645                 650                 655     


Met Tyr His Gly Ala Ala Phe Gln Leu Thr Gln Gly Asp Gln Leu Ser 
            660                 665                 670         


Thr His Thr Asp Gly Ile Pro His Leu Val Leu Ser Pro Ser Thr Val 
        675                 680                 685             


Phe Phe Gly Ala Phe Ala Leu 
    690                 695 


<210>  98
<211>  942
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  364B4 humanized anti-CDH3/hLTalpha beta beta  heavy chain 
       precursor


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  signal sequence

<400>  98

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Thr Tyr Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg His Tyr Tyr Gly Ser Asp Trp Tyr Phe Asp Val 
        115                 120                 125             


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys Ala His Ser Thr Leu Lys Pro Ala Ala His Leu 
465                 470                 475                 480 


Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg Ala Asn Thr 
                485                 490                 495     


Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn Asn Ser Leu 
            500                 505                 510         


Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln Val Val Phe 
        515                 520                 525             


Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro Leu Tyr Leu 
    530                 535                 540                 


Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe His Val Pro 
545                 550                 555                 560 


Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln Glu Pro Trp 
                565                 570                 575     


Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr Gln Gly Asp 
            580                 585                 590         


Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val Leu Ser Pro 
        595                 600                 605             


Ser Thr Val Phe Phe Gly Ala Phe Ala Leu Leu Ser Pro Gly Leu Pro 
    610                 615                 620                 


Ala Ala His Leu Ile Gly Ala Pro Leu Lys Gly Gln Gly Leu Gly Trp 
625                 630                 635                 640 


Glu Thr Thr Lys Glu Gln Ala Phe Leu Thr Ser Gly Thr Gln Phe Ser 
                645                 650                 655     


Asp Ala Glu Gly Leu Ala Leu Pro Gln Asp Gly Leu Tyr Tyr Leu Tyr 
            660                 665                 670         


Cys Leu Val Gly Tyr Arg Gly Arg Ala Pro Pro Gly Gly Gly Asp Pro 
        675                 680                 685             


Gln Gly Arg Ser Val Thr Leu Arg Ser Ser Leu Tyr Arg Ala Gly Gly 
    690                 695                 700                 


Ala Tyr Gly Pro Gly Thr Pro Glu Leu Leu Leu Glu Gly Ala Glu Thr 
705                 710                 715                 720 


Val Thr Pro Val Leu Asp Pro Ala Arg Arg Gln Gly Tyr Gly Pro Leu 
                725                 730                 735     


Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu Val Gln Leu Arg Arg Gly 
            740                 745                 750         


Glu Arg Val Tyr Val Asn Ile Ser His Pro Asp Met Val Asp Phe Ala 
        755                 760                 765             


Arg Gly Lys Thr Phe Phe Gly Ala Val Met Val Gly Leu Ser Pro Gly 
    770                 775                 780                 


Leu Pro Ala Ala His Leu Ile Gly Ala Pro Leu Lys Gly Gln Gly Leu 
785                 790                 795                 800 


Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe Leu Thr Ser Gly Thr Gln 
                805                 810                 815     


Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro Gln Asp Gly Leu Tyr Tyr 
            820                 825                 830         


Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg Ala Pro Pro Gly Gly Gly 
        835                 840                 845             


Asp Pro Gln Gly Arg Ser Val Thr Leu Arg Ser Ser Leu Tyr Arg Ala 
    850                 855                 860                 


Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu Leu Leu Leu Glu Gly Ala 
865                 870                 875                 880 


Glu Thr Val Thr Pro Val Leu Asp Pro Ala Arg Arg Gln Gly Tyr Gly 
                885                 890                 895     


Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu Val Gln Leu Arg 
            900                 905                 910         


Arg Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro Asp Met Val Asp 
        915                 920                 925             


Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala Val Met Val Gly 
    930                 935                 940         


<210>  99
<211>  923
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  364B4 humanized anti-CDH3/hLTalpha beta beta  heavy chain mature 
       protein

<400>  99

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Thr Ile Ser Asp Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg His Tyr Tyr Gly Ser Asp Trp Tyr Phe Asp Val Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Ala His Ser Thr Leu Lys Pro Ala Ala His Leu Ile Gly Asp 
    450                 455                 460                 


Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg Ala Asn Thr Asp Arg Ala 
465                 470                 475                 480 


Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn Asn Ser Leu Leu Val Pro 
                485                 490                 495     


Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln Val Val Phe Ser Gly Lys 
            500                 505                 510         


Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro Leu Tyr Leu Ala His Glu 
        515                 520                 525             


Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe His Val Pro Leu Leu Ser 
    530                 535                 540                 


Ser Gln Lys Met Val Tyr Pro Gly Leu Gln Glu Pro Trp Leu His Ser 
545                 550                 555                 560 


Met Tyr His Gly Ala Ala Phe Gln Leu Thr Gln Gly Asp Gln Leu Ser 
                565                 570                 575     


Thr His Thr Asp Gly Ile Pro His Leu Val Leu Ser Pro Ser Thr Val 
            580                 585                 590         


Phe Phe Gly Ala Phe Ala Leu Leu Ser Pro Gly Leu Pro Ala Ala His 
        595                 600                 605             


Leu Ile Gly Ala Pro Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr 
    610                 615                 620                 


Lys Glu Gln Ala Phe Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu 
625                 630                 635                 640 


Gly Leu Ala Leu Pro Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val 
                645                 650                 655     


Gly Tyr Arg Gly Arg Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg 
            660                 665                 670         


Ser Val Thr Leu Arg Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly 
        675                 680                 685             


Pro Gly Thr Pro Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro 
    690                 695                 700                 


Val Leu Asp Pro Ala Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr 
705                 710                 715                 720 


Ser Val Gly Phe Gly Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val 
                725                 730                 735     


Tyr Val Asn Ile Ser His Pro Asp Met Val Asp Phe Ala Arg Gly Lys 
            740                 745                 750         


Thr Phe Phe Gly Ala Val Met Val Gly Leu Ser Pro Gly Leu Pro Ala 
        755                 760                 765             


Ala His Leu Ile Gly Ala Pro Leu Lys Gly Gln Gly Leu Gly Trp Glu 
    770                 775                 780                 


Thr Thr Lys Glu Gln Ala Phe Leu Thr Ser Gly Thr Gln Phe Ser Asp 
785                 790                 795                 800 


Ala Glu Gly Leu Ala Leu Pro Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys 
                805                 810                 815     


Leu Val Gly Tyr Arg Gly Arg Ala Pro Pro Gly Gly Gly Asp Pro Gln 
            820                 825                 830         


Gly Arg Ser Val Thr Leu Arg Ser Ser Leu Tyr Arg Ala Gly Gly Ala 
        835                 840                 845             


Tyr Gly Pro Gly Thr Pro Glu Leu Leu Leu Glu Gly Ala Glu Thr Val 
    850                 855                 860                 


Thr Pro Val Leu Asp Pro Ala Arg Arg Gln Gly Tyr Gly Pro Leu Trp 
865                 870                 875                 880 


Tyr Thr Ser Val Gly Phe Gly Gly Leu Val Gln Leu Arg Arg Gly Glu 
                885                 890                 895     


Arg Val Tyr Val Asn Ile Ser His Pro Asp Met Val Asp Phe Ala Arg 
            900                 905                 910         


Gly Lys Thr Phe Phe Gly Ala Val Met Val Gly 
        915                 920             


<210>  100
<211>  2829
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  364B4 humanized anti-CDH3/hLTalpha beta beta  heavy chain 
       precursor DNA

<400>  100
atggactgga cctggaggat actctttctc gtggctgcag ccacaggagc ccactccgag       60

gtgcagctgg tgcaatctgg gggaggactg gtcaagcctg gggggtccct gagactctcc      120

tgtgcagcct ctggattcac cttctctacc tatggcatgt cttgggtccg ccaagctcca      180

gggaaggggc tggagtgggt cgcaaccatt tctgatggtg gtagctacac ctactatcca      240

gactccgtga aggggcggtt caccatctcc agagacaacg ccaagaactc actgtatctg      300

caaatgaaca gcctgagagc cgaggacaca gctgtgtatt actgtgctag acattactac      360

ggttctgact ggtacttcga tgtctggggg caagggacca ccgtcaccgt cagctcagcc      420

agcacaaagg gcccctccgt gttccctctg gccccttcct ccaagtccac ctccggcggc      480

accgccgctc tgggctgcct ggtgaaggac tacttccctg agcctgtgac cgtgtcctgg      540

aactctggcg ctctgacctc tggcgtccac accttcccag ccgtgctgca gtcctccggc      600

ctgtactccc tgtcctccgt ggtgactgtg ccttcctcct ccctgggcac ccagacctac      660

atctgcaacg tgaaccacaa gccttccaac accaaggtgg acaagcgggt ggagcctaag      720

tcctgcgaca agacccacac ctgccctccc tgccctgccc ctgagctgct gggcggacct      780

tccgtgttcc tgttccctcc taagcctaag gacaccctga tgatctcccg gacccctgag      840

gtgacatgcg tggtggtgga cgtgtcccac gaggaccctg aggtgaagtt caactggtat      900

gtggacggcg tggaagtgca taacgctaag accaagccaa gggaggagca gtacgcctcc      960

acctaccggg tggtgtctgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagaa     1020

tacaagtgca aggtctccaa caaggccctg cccgctccca tcgagaaaac catctccaag     1080

gccaagggcc agcctcgcga gcctcaggtg tacaccctgc cacccagccg ggaggagctg     1140

accaagaacc aggtgtccct gacctgtctg gtgaagggct tctacccttc cgatattgcc     1200

gtggagtggg agtctaacgg ccagcccgag aacaactaca agaccacccc tcctgtgctg     1260

gactccgacg gctccttctt cctgtactcc aagctgaccg tggacaagtc ccggtggcag     1320

cagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag     1380

aagtccctgt ctctgtctcc tggcaaggcc cacagcaccc tcaaacctgc tgctcacctc     1440

attggcgacc ccagcaagca aaactcactg ctctggcggg caaacactga ccgggccttc     1500

ctccaagatg gtttctccct ctctaacaat tctctcctgg tccccacctc tggcatctac     1560

ttcgtctact cccaagtggt cttctctggg aaagcctact ctcccaaagc cacctcctcc     1620

ccactctacc tggcccatga ggtccagctc ttctcctccc aatacccctt ccatgtgcct     1680

ctcctctctt cccaaaaaat ggtgtatcca gggctgcagg aaccctggct gcactctatg     1740

taccacgggg ctgctttcca actcacccag ggagaccagc tctccaccca cactgatggc     1800

atcccccacc tcgtcctctc tccttctact gtcttctttg gagccttcgc tctgctctca     1860

cccgggctcc cagctgccca cctcatcggc gctccactga aagggcaggg gctcggctgg     1920

gagactacta aggaacaggc ttttctgacc agcgggaccc agttctccga cgccgagggg     1980

ctggccctcc cccaggacgg cctctattac ctctactgtc tcgtcggcta ccggggccgc     2040

gccccccctg gcggcgggga cccccagggc cgctccgtca ccctgcgctc ctctctgtac     2100

cgggccgggg gcgcatacgg ccccggcact cccgagctgc tgctcgaagg ggccgagacc     2160

gtgactccag tgctggaccc cgccaggaga caaggctacg ggcctctctg gtacaccagc     2220

gtggggttcg gcggcctggt gcagctccgg aggggcgaga gggtgtacgt caacatctcc     2280

caccccgata tggtggactt cgccagaggg aagaccttct ttggggccgt gatggtcgga     2340

ctgtctcctg gcctgcctgc cgcacatctg attggtgccc ctctcaaagg acaaggactc     2400

ggatgggaaa caacaaaaga acaagcattc ctcacatccg gaacacaatt ttctgatgca     2460

gaagggctcg cactgccaca agatgggctg tactatctgt attgcctggt tgggtatcgc     2520

ggtcgcgcac ctcccggggg gggcgatcct caagggcggt cagttaccct ccggagcagc     2580

ctctatcggg caggcggggc ttatggacct ggaacccctg aactcctcct ggaaggggct     2640

gaaaccgtca cccccgtcct cgatcccgct cggcggcaag gctatggccc cctgtggtat     2700

acctccgtcg gctttggggg gctcgtccaa ctgcgccggg gggaacgggt ctatgtgaat     2760

atttcccatc ctgacatggt cgattttgcc cggggcaaaa catttttcgg cgctgtcatg     2820

gtcggctga                                                             2829


<210>  101
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  364B4 humanized anti-CDH3/hLTalpha beta beta  light chain 
       precursor protein


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  signal sequence

<400>  101

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser 
        35                  40                  45              


Ile Val Gln Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Gln Phe 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Phe Gln Gly Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  102
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  364B4 humanized anti-CDH3/hLTalpha beta beta  light chain mature 
       protein

<400>  102

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val Gln Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Gln Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


<210>  103
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  364B4 humanized anti-CDH3/hLTalpha beta beta  light chain 
       precursor DNA

<400>  103
atggtgctcc agacccaggt cttcatttcc ctgctgctct ggatcagcgg agcctacggg       60

gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gcctgcctcc      120

atctcctgcc ggtcttcaca atccattgtt caatctaatg gaaacaccta tctcgaatgg      180

tatctgcaga agccagggca gtctccacag ctcctgatct ataaagtttc caaccaattt      240

tctggggtcc ctgatcggtt ctctggctct ggatcaggca cagattttac actgaaaatc      300

agcagagtgg aggctgagga tgttggggtt tattactgct ttcaaggttc acatgttcct      360

ctcacattcg gccaagggac caaggtggaa atcaagcgta cggtggctgc accatctgtc      420

ttcatcttcc ctccatctga tgagcagctc aaatctggaa ctgcctctgt tgtgtgcctg      480

ctgaataact tctatcccag agaggccaaa gtccagtgga aggtggataa cgccctccaa      540

tccggcaact cccaggaatc tgtcacagag caggacagca aggacagcac ctacagcctc      600

agctccaccc tgacactgag caaagcagac tacgagaaac acaaagtcta tgcctgcgaa      660

gtcacccatc agggcctgtc ttcccccgtc acaaagagct tcaacagggg agagtgctaa      720


<210>  104
<211>  937
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  349B4 humanized anti-B7-H4/ hLTalpha beta beta  heavy chain 
       precursor protein


<220>  (1)..(19)
<221>  misc_feature
<223>  signal sequence

<400>  104

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu 
    50                  55                  60                  


Glu Trp Met Gly Tyr Val Asp Pro Phe Asn Gly Gly Thr Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Phe Ile Ala Gly Phe Ala Asn Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Glu Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


Ala His Ser Thr Leu Lys Pro Ala Ala His Leu Ile Gly Asp Pro Ser 
465                 470                 475                 480 


Lys Gln Asn Ser Leu Leu Trp Arg Ala Asn Thr Asp Arg Ala Phe Leu 
                485                 490                 495     


Gln Asp Gly Phe Ser Leu Ser Asn Asn Ser Leu Leu Val Pro Thr Ser 
            500                 505                 510         


Gly Ile Tyr Phe Val Tyr Ser Gln Val Val Phe Ser Gly Lys Ala Tyr 
        515                 520                 525             


Ser Pro Lys Ala Thr Ser Ser Pro Leu Tyr Leu Ala His Glu Val Gln 
    530                 535                 540                 


Leu Phe Ser Ser Gln Tyr Pro Phe His Val Pro Leu Leu Ser Ser Gln 
545                 550                 555                 560 


Lys Met Val Tyr Pro Gly Leu Gln Glu Pro Trp Leu His Ser Met Tyr 
                565                 570                 575     


His Gly Ala Ala Phe Gln Leu Thr Gln Gly Asp Gln Leu Ser Thr His 
            580                 585                 590         


Thr Asp Gly Ile Pro His Leu Val Leu Ser Pro Ser Thr Val Phe Phe 
        595                 600                 605             


Gly Ala Phe Ala Leu Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile 
    610                 615                 620                 


Gly Ala Pro Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu 
625                 630                 635                 640 


Gln Ala Phe Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu 
                645                 650                 655     


Ala Leu Pro Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr 
            660                 665                 670         


Arg Gly Arg Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val 
        675                 680                 685             


Thr Leu Arg Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly 
    690                 695                 700                 


Thr Pro Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu 
705                 710                 715                 720 


Asp Pro Ala Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val 
                725                 730                 735     


Gly Phe Gly Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val 
            740                 745                 750         


Asn Ile Ser His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe 
        755                 760                 765             


Phe Gly Ala Val Met Val Gly Leu Ser Pro Gly Leu Pro Ala Ala His 
    770                 775                 780                 


Leu Ile Gly Ala Pro Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr 
785                 790                 795                 800 


Lys Glu Gln Ala Phe Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu 
                805                 810                 815     


Gly Leu Ala Leu Pro Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val 
            820                 825                 830         


Gly Tyr Arg Gly Arg Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg 
        835                 840                 845             


Ser Val Thr Leu Arg Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly 
    850                 855                 860                 


Pro Gly Thr Pro Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro 
865                 870                 875                 880 


Val Leu Asp Pro Ala Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr 
                885                 890                 895     


Ser Val Gly Phe Gly Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val 
            900                 905                 910         


Tyr Val Asn Ile Ser His Pro Asp Met Val Asp Phe Ala Arg Gly Lys 
        915                 920                 925             


Thr Phe Phe Gly Ala Val Met Val Gly 
    930                 935         


<210>  105
<211>  918
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  349B4 humanized anti-B7-H4/hLTalpha beta beta  mature chain 
       mature protein

<400>  105

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Val Asp Pro Phe Asn Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Phe Ile Ala Gly Phe Ala Asn Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ala His Ser 
        435                 440                 445             


Thr Leu Lys Pro Ala Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn 
    450                 455                 460                 


Ser Leu Leu Trp Arg Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly 
465                 470                 475                 480 


Phe Ser Leu Ser Asn Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr 
                485                 490                 495     


Phe Val Tyr Ser Gln Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys 
            500                 505                 510         


Ala Thr Ser Ser Pro Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser 
        515                 520                 525             


Ser Gln Tyr Pro Phe His Val Pro Leu Leu Ser Ser Gln Lys Met Val 
    530                 535                 540                 


Tyr Pro Gly Leu Gln Glu Pro Trp Leu His Ser Met Tyr His Gly Ala 
545                 550                 555                 560 


Ala Phe Gln Leu Thr Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly 
                565                 570                 575     


Ile Pro His Leu Val Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe 
            580                 585                 590         


Ala Leu Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly Ala Pro 
        595                 600                 605             


Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe 
    610                 615                 620                 


Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro 
625                 630                 635                 640 


Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg 
                645                 650                 655     


Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr Leu Arg 
            660                 665                 670         


Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu 
        675                 680                 685             


Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp Pro Ala 
    690                 695                 700                 


Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly 
705                 710                 715                 720 


Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn Ile Ser 
                725                 730                 735     


His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala 
            740                 745                 750         


Val Met Val Gly Leu Ser Pro Gly Leu Pro Ala Ala His Leu Ile Gly 
        755                 760                 765             


Ala Pro Leu Lys Gly Gln Gly Leu Gly Trp Glu Thr Thr Lys Glu Gln 
    770                 775                 780                 


Ala Phe Leu Thr Ser Gly Thr Gln Phe Ser Asp Ala Glu Gly Leu Ala 
785                 790                 795                 800 


Leu Pro Gln Asp Gly Leu Tyr Tyr Leu Tyr Cys Leu Val Gly Tyr Arg 
                805                 810                 815     


Gly Arg Ala Pro Pro Gly Gly Gly Asp Pro Gln Gly Arg Ser Val Thr 
            820                 825                 830         


Leu Arg Ser Ser Leu Tyr Arg Ala Gly Gly Ala Tyr Gly Pro Gly Thr 
        835                 840                 845             


Pro Glu Leu Leu Leu Glu Gly Ala Glu Thr Val Thr Pro Val Leu Asp 
    850                 855                 860                 


Pro Ala Arg Arg Gln Gly Tyr Gly Pro Leu Trp Tyr Thr Ser Val Gly 
865                 870                 875                 880 


Phe Gly Gly Leu Val Gln Leu Arg Arg Gly Glu Arg Val Tyr Val Asn 
                885                 890                 895     


Ile Ser His Pro Asp Met Val Asp Phe Ala Arg Gly Lys Thr Phe Phe 
            900                 905                 910         


Gly Ala Val Met Val Gly 
        915             


<210>  106
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  349B4 humanized anti-B7-H4/hLTalpha beta beta  light chain 
       precursor protein


<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  signal sequence

<400>  106

Met Val Leu Gln Thr Gln Val Phe Ile Ser Leu Leu Leu Trp Ile Ser 
1               5                   10                  15      


Gly Ala Tyr Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Ile Lys Ser Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Gly 
            100                 105                 110         


Glu Ser Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  107
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  349B4 humanized anti-B7-H4/hLTalpha beta beta  light chain mature
       protein

<400>  107

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  108
<211>  157
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Minimal LTbeta  sequence (aa 87-243)

<400>  108

Leu Pro Ala Ala His Leu Ile Gly Ala Pro Leu Lys Gly Gln Gly Leu 
1               5                   10                  15      


Gly Trp Glu Thr Thr Lys Glu Gln Ala Phe Leu Thr Ser Gly Thr Gln 
            20                  25                  30          


Phe Ser Asp Ala Glu Gly Leu Ala Leu Pro Gln Asp Gly Leu Tyr Tyr 
        35                  40                  45              


Leu Tyr Cys Leu Val Gly Tyr Arg Gly Arg Ala Pro Pro Gly Gly Gly 
    50                  55                  60                  


Asp Pro Gln Gly Arg Ser Val Thr Leu Arg Ser Ser Leu Tyr Arg Ala 
65                  70                  75                  80  


Gly Gly Ala Tyr Gly Pro Gly Thr Pro Glu Leu Leu Leu Glu Gly Ala 
                85                  90                  95      


Glu Thr Val Thr Pro Val Leu Asp Pro Ala Arg Arg Gln Gly Tyr Gly 
            100                 105                 110         


Pro Leu Trp Tyr Thr Ser Val Gly Phe Gly Gly Leu Val Gln Leu Arg 
        115                 120                 125             


Arg Gly Glu Arg Val Tyr Val Asn Ile Ser His Pro Asp Met Val Asp 
    130                 135                 140                 


Phe Ala Arg Gly Lys Thr Phe Phe Gly Ala Val Met Val 
145                 150                 155         


