                         SEQUENCE LISTING

<110>  WINDMIL THERAPEUTICS, INC.
       Noonan, Kimberly A.
       Lutz, Eric R.
 
<120>  Compositions And Methods For Modulating The Immune System

<130>  144502.00502

<150>  62/438,106
<151>  2016-12-22

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD Leader Peptide

<400>  1

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  2
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD Leader Peptide

<400>  2
atggccctgc ccgtgaccgc cctgctcctg cctctggctc tgctgctgca tgccgccaga       60

cct                                                                     63


<210>  3
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain

<400>  3

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val 
145                 150 


<210>  4
<211>  450
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain

<400>  4
cccggctggt tcctggacag ccccgacaga ccctggaacc ctcccacctt cagccctgcc       60

ctgctcgtgg tgacagaggg cgacaacgcc accttcacct gtagcttcag caacaccagc      120

gagagcttcg tgctgaactg gtacagaatg agccccagca accagaccga caagctggcc      180

gccttccccg aggacagaag ccagcccggc caggactgcc ggttcagagt gacccagctg      240

cccaacggcc gggacttcca catgagcgtg gtgcgcgcca gacggaacga cagcggcaca      300

tacctgtgcg gcgccatcag cctggcccct aaggcccaga tcaaagagag cctgcgggcc      360

gagctgagag tgaccgagag aagggccgag gtgcccaccg cccaccctag cccatctcca      420

agacctgccg gccagttcca gaccctggtg                                       450


<210>  5
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB Transmembrane Domain

<400>  5

Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  6
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB Transmembrane Domain

<400>  6
atcatctcat tctttctggc cctgaccagc acagccctgc tgtttctgct gttcttcctg       60

accctgcggt tcagcgtggt g                                                 81


<210>  7
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB Intracellular Domain

<400>  7

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  8
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB Intracellular Domain

<400>  8
aaacggggca gaaagaagct gctgtacatc ttcaagcagc ccttcatgcg g                51


<210>  9
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 Transmembrane Domain

<400>  9

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  10
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 Transmembrane Domain

<400>  10
ttttgggtgc tcgtggtcgt tggcggagtg ctggcctgtt atagcctgct ggtcaccgtg       60

gccttcatca tcttttgggt c                                                 81


<210>  11
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 Intracellular Domain

<400>  11

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  12
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 Intracellular Domain

<400>  12
cgaagcaagc ggagccggct gctgcacagc gactacatga acatgacccc tagacggccc       60

ggacctacca gaaagcacta ccagccttac gctcctccta gagacttcgc cgcctacaga      120

tct                                                                    123


<210>  13
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD27 Transmembrane Domain

<400>  13

Ile Leu Val Ile Phe Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly 
1               5                   10                  15      


Ala Leu Phe Leu His 
            20      


<210>  14
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD27 Transmembrane Domain

<400>  14
atcctcgtga tcttcagcgg catgttcctg gtgttcacac tggctggcgc cctgtttctg       60

cac                                                                     63


<210>  15
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD27 Intracellular Domain

<400>  15

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  16
<211>  144
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD27 Intracellular Domain

<400>  16
cagcggagaa agtacagaag caacaagggc gagagccccg tggaacctgc cgagccttgt       60

agatacagct gtcccagaga ggaagagggc agcacaatcc ccatccaaga ggactacaga      120

aagcccgagc ctgcctgctc tcct                                             144


<210>  17
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS Transmembrane Domain

<400>  17

Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu 
1               5                   10                  15      


Gly Cys Ile Leu Ile 
            20      


<210>  18
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOS Transmembrane Domain

<400>  18
ttctggctgc ctatcggctg tgccgctttt gtggtcgtgt gcatcctggg ctgcatcctg       60

atc                                                                     63


<210>  19
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ICOS Intracellular Domain

<400>  19

Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
1               5                   10                  15      


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
            20                  25                  30          


Leu Thr Asp Val Thr Leu 
        35              


<210>  20
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ICOS Intracellular Domain

<400>  20
tgctggctga ccaagaaaaa gtacagcagc agcgtgcacg accccaacgg cgagtacatg       60

ttcatgagag ccgtgaacac cgccaagaag tccagactga ccgacgtgac cctt            114


<210>  21
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; 4-1BB Transmembrane Domain; 4-1BB 
       Intracellular Domain

<400>  21

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser 
145                 150                 155                 160 


Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val 
                165                 170                 175     


Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            180                 185                 190         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        195                 200                 205             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    210                 215                 


<210>  22
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; 4-1BB Transmembrane Domain; 4-1BB 
       Intracellular Domain

<400>  22
cccggctggt tcctggacag ccccgacaga ccctggaacc ctcccacctt cagccctgcc       60

ctgctcgtgg tgacagaggg cgacaacgcc accttcacct gtagcttcag caacaccagc      120

gagagcttcg tgctgaactg gtacagaatg agccccagca accagaccga caagctggcc      180

gccttccccg aggacagaag ccagcccggc caggactgcc ggttcagagt gacccagctg      240

cccaacggcc gggacttcca catgagcgtg gtgcgcgcca gacggaacga cagcggcaca      300

tacctgtgcg gcgccatcag cctggcccct aaggcccaga tcaaagagag cctgcgggcc      360

gagctgagag tgaccgagag aagggccgag gtgcccaccg cccaccctag cccatctcca      420

agacctgccg gccagttcca gaccctggtg atcatctcat tctttctggc cctgaccagc      480

acagccctgc tgtttctgct gttcttcctg accctgcggt tcagcgtggt gaaacggggc      540

agaaagaagc tgctgtacat cttcaagcag cccttcatgc ggcccgtgca gaccacccag      600

gaagaagacg gctgcagctg ccggttcccc gaagaagaag agggcggctg cgaactg         657


<210>  23
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; CD28 Transmembrane Domain; CD28 
       Intracellular Domain

<400>  23

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Phe Trp Val Leu Val Val Val Gly Gly Val 
145                 150                 155                 160 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                165                 170                 175     


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            180                 185                 190         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        195                 200                 205             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
    210                 215             


<210>  24
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; CD28 Transmembrane Domain; CD28 
       Intracellular Domain

<400>  24
ccaggctggt tcctggactc tcccgacaga ccttggaacc ctccaacatt cagccccgct       60

ctgctggtgg ttaccgaggg cgataatgcc accttcacct gtagcttcag caacaccagc      120

gagagcttcg tgctgaactg gtacagaatg agccccagca accagaccga caagctggcc      180

gcctttcctg aggatagatc tcagcccggc caggactgcc ggttcagagt tacacagctg      240

cccaacggcc gggacttcca catgtctgtc gtccgggcca gaagaaacga cagcggcaca      300

tatctgtgcg gcgccatttc tctggcccct aaggctcaga tcaaagagag cctgagagcc      360

gagctgagag tgacagaaag acgggccgaa gtgcccacag ctcacccttc accttctcca      420

agacctgccg gccagtttca gaccctggtg ttttgggtgc tcgtggtcgt tggcggagtg      480

ctggcctgtt atagcctgct ggtcaccgtg gccttcatca tcttttgggt ccgaagcaag      540

cggagccggc tgctgcacag cgactacatg aacatgaccc ctagacggcc cggacctacc      600

agaaagcact accagcctta cgctcctcct agagacttcg ccgcctacag atct            654


<210>  25
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; CD28 Transmembrane Domain; CD28 
       Intracellular Domain; 4-1BB Intracellular Domain

<400>  25

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Phe Trp Val Leu Val Val Val Gly Gly Val 
145                 150                 155                 160 


Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp 
                165                 170                 175     


Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met 
            180                 185                 190         


Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala 
        195                 200                 205             


Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys 
    210                 215                 220                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
225                 230                 235                 240 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                245                 250                 255     


Gly Cys Glu Leu 
            260 


<210>  26
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; CD28 Transmembrane Domain; CD28 
       Intracellular Domain; 4-1BB Intracellular Domain

<400>  26
ccaggctggt tcctggactc tcccgacaga ccttggaacc ctccaacatt cagccccgct       60

ctgctggtgg ttaccgaggg cgataatgcc accttcacct gtagcttcag caacaccagc      120

gagagcttcg tgctgaactg gtacagaatg agccccagca accagaccga caagctggcc      180

gcctttcctg aggatagatc tcagcccggc caggactgcc ggttcagagt tacacagctg      240

cccaacggcc gggacttcca catgtctgtc gtccgggcca gaagaaacga cagcggcaca      300

tatctgtgcg gcgccatttc tctggcccct aaggctcaga tcaaagagag cctgagagcc      360

gagctgagag tgacagaaag acgggccgaa gtgcccacag ctcacccttc accttctcca      420

agacctgccg gccagtttca gaccctggtg ttttgggtgc tcgtggtcgt tggcggagtg      480

ctggcctgtt atagcctgct ggtcaccgtg gccttcatca tcttttgggt ccgaagcaag      540

cggagccggc tgctgcacag cgactacatg aacatgaccc ctagacggcc cggacctacc      600

agaaagcact accagcctta cgctcctcct agagacttcg ccgcctacag atccaagcgg      660

ggcagaaaga agctgctgta catcttcaag cagcccttca tgcggcccgt gcagaccaca      720

caagaggaag atggctgctc ctgcagattc cccgaggaag aagaaggcgg ctgcgagctt      780


<210>  27
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; CD27 Transmembrane Domain; CD27 
       Intracellular Domain

<400>  27

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Ile Leu Val Ile Phe Ser Gly Met Phe Leu 
145                 150                 155                 160 


Val Phe Thr Leu Ala Gly Ala Leu Phe Leu His Gln Arg Arg Lys Tyr 
                165                 170                 175     


Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro Cys Arg 
            180                 185                 190         


Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu 
        195                 200                 205             


Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
    210                 215                 


<210>  28
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; CD27 Transmembrane Domain; CD27 
       Intracellular Domain

<400>  28
ccaggctggt tcctggactc tcccgacaga ccttggaacc ctccaacatt cagccccgct       60

ctgctggtgg ttaccgaggg cgataatgcc accttcacct gtagcttcag caacaccagc      120

gagagcttcg tgctgaactg gtacagaatg agccccagca accagaccga caagctggcc      180

gcctttcctg aggatagatc tcagcccggc caggactgcc ggttcagagt tacacagctg      240

cccaacggcc gggacttcca catgtctgtc gtccgggcca gaagaaacga cagcggcaca      300

tatctgtgcg gcgccatttc tctggcccct aaggctcaga tcaaagagag cctgagagcc      360

gagctgagag tgacagaaag acgggccgaa gtgcccacag ctcacccttc accttctcca      420

agacctgccg gccagtttca gaccctggtc atcctcgtga tcttcagcgg catgttcctg      480

gtgttcacac tggctggcgc cctgtttctg caccagcgga gaaagtacag aagcaacaag      540

ggcgagagcc ccgtggaacc tgccgagcct tgtagataca gctgtcccag agaggaagag      600

ggcagcacaa tccccatcca agaggactac agaaagcccg agcctgcctg ctctcct         657


<210>  29
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; CD27 Transmembrane Domain; CD27 
       Intracellular Domain; 4-1BB Intracellular Domain

<400>  29

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Ile Leu Val Ile Phe Ser Gly Met Phe Leu 
145                 150                 155                 160 


Val Phe Thr Leu Ala Gly Ala Leu Phe Leu His Gln Arg Arg Lys Tyr 
                165                 170                 175     


Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro Ala Glu Pro Cys Arg 
            180                 185                 190         


Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr Ile Pro Ile Gln Glu 
        195                 200                 205             


Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro Lys Arg Gly Arg Lys 
    210                 215                 220                 


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
225                 230                 235                 240 


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
                245                 250                 255     


Gly Gly Cys Glu Leu 
            260     


<210>  30
<211>  783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; CD27 Transmembrane Domain; CD27 
       Intracellular Domain; 4-1BB Intracellular Domain

<400>  30
ccaggctggt tcctggactc tcccgacaga ccttggaacc ctccaacatt cagccccgct       60

ctgctggtgg ttaccgaggg cgataatgcc accttcacct gtagcttcag caacaccagc      120

gagagcttcg tgctgaactg gtacagaatg agccccagca accagaccga caagctggcc      180

gcctttcctg aggatagatc tcagcccggc caggactgcc ggttcagagt tacacagctg      240

cccaacggcc gggacttcca catgtctgtc gtccgggcca gaagaaacga cagcggcaca      300

tatctgtgcg gcgccatttc tctggcccct aaggctcaga tcaaagagag cctgagagcc      360

gagctgagag tgacagaaag acgggccgaa gtgcccacag ctcacccttc accttctcca      420

agacctgccg gccagtttca gaccctggtc atcctcgtga tcttcagcgg catgttcctg      480

gtgttcacac tggctggcgc cctgtttctg caccagcgga gaaagtacag aagcaacaag      540

ggcgagagcc ccgtggaacc tgccgagcct tgtagataca gctgtcccag agaggaagag      600

ggcagcacaa tccccatcca agaggactac agaaagcccg agcctgcctg ctctcccaag      660

agaggcagaa agaagctgct gtacatcttc aagcagccct tcatgcggcc cgtgcagacc      720

acacaagagg aagatggctg ctcctgcaga ttccccgagg aagaagaagg cggctgcgag      780

ctt                                                                    783


<210>  31
<211>  209
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; ICOS Transmembrane Domain; ICOS 
       Intracellular Domain

<400>  31

Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr 
1               5                   10                  15      


Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe 
            20                  25                  30          


Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr 
        35                  40                  45              


Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu 
    50                  55                  60                  


Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu 
65                  70                  75                  80  


Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn 
                85                  90                  95      


Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala 
            100                 105                 110         


Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg 
        115                 120                 125             


Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser Pro Arg Pro Ala Gly 
    130                 135                 140                 


Gln Phe Gln Thr Leu Val Phe Trp Leu Pro Ile Gly Cys Ala Ala Phe 
145                 150                 155                 160 


Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile Cys Trp Leu Thr Lys 
                165                 170                 175     


Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn Gly Glu Tyr Met Phe 
            180                 185                 190         


Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg Leu Thr Asp Val Thr 
        195                 200                 205             


Leu 
    


<210>  32
<211>  627
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; ICOS Transmembrane Domain; ICOS 
       Intracellular Domain

<400>  32
ccaggctggt tcctggactc tcccgacaga ccttggaacc ctccaacatt cagccccgct       60

ctgctggtgg ttaccgaggg cgataatgcc accttcacct gtagcttcag caacaccagc      120

gagagcttcg tgctgaactg gtacagaatg agccccagca accagaccga caagctggcc      180

gcctttcctg aggatagatc tcagcccggc caggactgcc ggttcagagt tacacagctg      240

cccaacggcc gggacttcca catgtctgtc gtccgggcca gaagaaacga cagcggcaca      300

tatctgtgcg gcgccatttc tctggcccct aaggctcaga tcaaagagag cctgagagcc      360

gagctgagag tgacagaaag acgggccgaa gtgcccacag ctcacccttc accttctcca      420

agacctgccg gccagtttca gaccctggtg ttctggctgc ctatcggctg tgccgctttt      480

gtggtcgtgt gcatcctggg ctgcatcctg atctgctggc tgaccaagaa aaagtacagc      540

agcagcgtgc acgaccccaa cggcgagtac atgttcatga gagccgtgaa caccgccaag      600

aagtccagac tgaccgacgt gaccctt                                          627


<210>  33
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; 4-1BB Transmembrane Domain; 4-1BB 
       Intracellular Domain

<400>  33

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro 
            20                  25                  30          


Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
        35                  40                  45              


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
    50                  55                  60                  


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
65                  70                  75                  80  


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
                85                  90                  95      


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
            100                 105                 110         


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
        115                 120                 125             


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
    130                 135                 140                 


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
145                 150                 155                 160 


Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Ile Ile Ser Phe Phe 
                165                 170                 175     


Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr 
            180                 185                 190         


Leu Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
        195                 200                 205             


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
    210                 215                 220                 


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230                 235                 240 


<210>  34
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; 4-1BB Transmembrane Domain; 4-1BB 
       Intracellular Domain

<400>  34
atggccctgc ccgtgaccgc cctgctcctg cctctggctc tgctgctgca tgccgccaga       60

cctcccggct ggttcctgga cagccccgac agaccctgga accctcccac cttcagccct      120

gccctgctcg tggtgacaga gggcgacaac gccaccttca cctgtagctt cagcaacacc      180

agcgagagct tcgtgctgaa ctggtacaga atgagcccca gcaaccagac cgacaagctg      240

gccgccttcc ccgaggacag aagccagccc ggccaggact gccggttcag agtgacccag      300

ctgcccaacg gccgggactt ccacatgagc gtggtgcgcg ccagacggaa cgacagcggc      360

acatacctgt gcggcgccat cagcctggcc cctaaggccc agatcaaaga gagcctgcgg      420

gccgagctga gagtgaccga gagaagggcc gaggtgccca ccgcccaccc tagcccatct      480

ccaagacctg ccggccagtt ccagaccctg gtgatcatct cattctttct ggccctgacc      540

agcacagccc tgctgtttct gctgttcttc ctgaccctgc ggttcagcgt ggtgaaacgg      600

ggcagaaaga agctgctgta catcttcaag cagcccttca tgcggcccgt gcagaccacc      660

caggaagaag acggctgcag ctgccggttc cccgaagaag aagagggcgg ctgcgaactg      720


<210>  35
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; CD28 Transmembrane Domain; CD28 
       Intracellular Domain

<400>  35

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro 
            20                  25                  30          


Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
        35                  40                  45              


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
    50                  55                  60                  


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
65                  70                  75                  80  


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
                85                  90                  95      


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
            100                 105                 110         


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
        115                 120                 125             


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
    130                 135                 140                 


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
145                 150                 155                 160 


Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Phe Trp Val Leu Val 
                165                 170                 175     


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
            180                 185                 190         


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        195                 200                 205             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    210                 215                 220                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
225                 230                 235                 


<210>  36
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; CD28 Transmembrane Domain; CD28 
       Intracellular Domain

<400>  36
atggccctgc ctgtgacagc tctgctgctg cctcttgctc tgcttctgca tgccgctaga       60

cctccaggct ggttcctgga ctctcccgac agaccttgga accctccaac attcagcccc      120

gctctgctgg tggttaccga gggcgataat gccaccttca cctgtagctt cagcaacacc      180

agcgagagct tcgtgctgaa ctggtacaga atgagcccca gcaaccagac cgacaagctg      240

gccgcctttc ctgaggatag atctcagccc ggccaggact gccggttcag agttacacag      300

ctgcccaacg gccgggactt ccacatgtct gtcgtccggg ccagaagaaa cgacagcggc      360

acatatctgt gcggcgccat ttctctggcc cctaaggctc agatcaaaga gagcctgaga      420

gccgagctga gagtgacaga aagacgggcc gaagtgccca cagctcaccc ttcaccttct      480

ccaagacctg ccggccagtt tcagaccctg gtgttttggg tgctcgtggt cgttggcgga      540

gtgctggcct gttatagcct gctggtcacc gtggccttca tcatcttttg ggtccgaagc      600

aagcggagcc ggctgctgca cagcgactac atgaacatga cccctagacg gcccggacct      660

accagaaagc actaccagcc ttacgctcct cctagagact tcgccgccta cagatct         717


<210>  37
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; CD28 Transmembrane Domain; CD28 
       Intracellular Domain; 4-1BB Intracellular Domain

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro 
            20                  25                  30          


Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
        35                  40                  45              


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
    50                  55                  60                  


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
65                  70                  75                  80  


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
                85                  90                  95      


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
            100                 105                 110         


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
        115                 120                 125             


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
    130                 135                 140                 


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
145                 150                 155                 160 


Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Phe Trp Val Leu Val 
                165                 170                 175     


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
            180                 185                 190         


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        195                 200                 205             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    210                 215                 220                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys 
225                 230                 235                 240 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
                245                 250                 255     


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
            260                 265                 270         


Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        275                 280     


<210>  38
<211>  843
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; CD28 Transmembrane Domain; CD28 
       Intracellular Domain; 4-1BB Intracellular Domain

<400>  38
atggccctgc ctgtgacagc tctgctgctg cctcttgctc tgcttctgca tgccgctaga       60

cctccaggct ggttcctgga ctctcccgac agaccttgga accctccaac attcagcccc      120

gctctgctgg tggttaccga gggcgataat gccaccttca cctgtagctt cagcaacacc      180

agcgagagct tcgtgctgaa ctggtacaga atgagcccca gcaaccagac cgacaagctg      240

gccgcctttc ctgaggatag atctcagccc ggccaggact gccggttcag agttacacag      300

ctgcccaacg gccgggactt ccacatgtct gtcgtccggg ccagaagaaa cgacagcggc      360

acatatctgt gcggcgccat ttctctggcc cctaaggctc agatcaaaga gagcctgaga      420

gccgagctga gagtgacaga aagacgggcc gaagtgccca cagctcaccc ttcaccttct      480

ccaagacctg ccggccagtt tcagaccctg gtgttttggg tgctcgtggt cgttggcgga      540

gtgctggcct gttatagcct gctggtcacc gtggccttca tcatcttttg ggtccgaagc      600

aagcggagcc ggctgctgca cagcgactac atgaacatga cccctagacg gcccggacct      660

accagaaagc actaccagcc ttacgctcct cctagagact tcgccgccta cagatccaag      720

cggggcagaa agaagctgct gtacatcttc aagcagccct tcatgcggcc cgtgcagacc      780

acacaagagg aagatggctg ctcctgcaga ttccccgagg aagaagaagg cggctgcgag      840

ctt                                                                    843


<210>  39
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; CD27 Transmembrane Domain; CD27 
       Intracellular Domain

<400>  39

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro 
            20                  25                  30          


Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
        35                  40                  45              


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
    50                  55                  60                  


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
65                  70                  75                  80  


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
                85                  90                  95      


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
            100                 105                 110         


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
        115                 120                 125             


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
    130                 135                 140                 


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
145                 150                 155                 160 


Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Ile Leu Val Ile Phe 
                165                 170                 175     


Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala Leu Phe Leu His 
            180                 185                 190         


Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
        195                 200                 205             


Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
    210                 215                 220                 


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
225                 230                 235                 240 


<210>  40
<211>  720
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; CD27 Transmembrane Domain; CD27 
       Intracellular Domain

<400>  40
atggccctgc ctgtgacagc tctgctgctg cctcttgctc tgcttctgca tgccgctaga       60

cctccaggct ggttcctgga ctctcccgac agaccttgga accctccaac attcagcccc      120

gctctgctgg tggttaccga gggcgataat gccaccttca cctgtagctt cagcaacacc      180

agcgagagct tcgtgctgaa ctggtacaga atgagcccca gcaaccagac cgacaagctg      240

gccgcctttc ctgaggatag atctcagccc ggccaggact gccggttcag agttacacag      300

ctgcccaacg gccgggactt ccacatgtct gtcgtccggg ccagaagaaa cgacagcggc      360

acatatctgt gcggcgccat ttctctggcc cctaaggctc agatcaaaga gagcctgaga      420

gccgagctga gagtgacaga aagacgggcc gaagtgccca cagctcaccc ttcaccttct      480

ccaagacctg ccggccagtt tcagaccctg gtcatcctcg tgatcttcag cggcatgttc      540

ctggtgttca cactggctgg cgccctgttt ctgcaccagc ggagaaagta cagaagcaac      600

aagggcgaga gccccgtgga acctgccgag ccttgtagat acagctgtcc cagagaggaa      660

gagggcagca caatccccat ccaagaggac tacagaaagc ccgagcctgc ctgctctcct      720


<210>  41
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain;  CD27 Transmembrane Domain; CD27 
       Intracellular Domain; 4-1BB Intracellular Domain

<400>  41

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro 
            20                  25                  30          


Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
        35                  40                  45              


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
    50                  55                  60                  


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
65                  70                  75                  80  


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
                85                  90                  95      


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
            100                 105                 110         


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
        115                 120                 125             


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
    130                 135                 140                 


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
145                 150                 155                 160 


Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Ile Leu Val Ile Phe 
                165                 170                 175     


Ser Gly Met Phe Leu Val Phe Thr Leu Ala Gly Ala Leu Phe Leu His 
            180                 185                 190         


Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
        195                 200                 205             


Ala Glu Pro Cys Arg Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
    210                 215                 220                 


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
225                 230                 235                 240 


Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
                245                 250                 255     


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            260                 265                 270         


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        275                 280         


<210>  42
<211>  846
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain;  CD27 Transmembrane Domain; CD27 
       Intracellular Domain; 4-1BB Intracellular Domain

<400>  42
atggccctgc ctgtgacagc tctgctgctg cctcttgctc tgcttctgca tgccgctaga       60

cctccaggct ggttcctgga ctctcccgac agaccttgga accctccaac attcagcccc      120

gctctgctgg tggttaccga gggcgataat gccaccttca cctgtagctt cagcaacacc      180

agcgagagct tcgtgctgaa ctggtacaga atgagcccca gcaaccagac cgacaagctg      240

gccgcctttc ctgaggatag atctcagccc ggccaggact gccggttcag agttacacag      300

ctgcccaacg gccgggactt ccacatgtct gtcgtccggg ccagaagaaa cgacagcggc      360

acatatctgt gcggcgccat ttctctggcc cctaaggctc agatcaaaga gagcctgaga      420

gccgagctga gagtgacaga aagacgggcc gaagtgccca cagctcaccc ttcaccttct      480

ccaagacctg ccggccagtt tcagaccctg gtcatcctcg tgatcttcag cggcatgttc      540

ctggtgttca cactggctgg cgccctgttt ctgcaccagc ggagaaagta cagaagcaac      600

aagggcgaga gccccgtgga acctgccgag ccttgtagat acagctgtcc cagagaggaa      660

gagggcagca caatccccat ccaagaggac tacagaaagc ccgagcctgc ctgctctccc      720

aagagaggca gaaagaagct gctgtacatc ttcaagcagc ccttcatgcg gcccgtgcag      780

accacacaag aggaagatgg ctgctcctgc agattccccg aggaagaaga aggcggctgc      840

gagctt                                                                 846


<210>  43
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; ICOS Transmembrane Domain; ICOS 
       Intracellular Domain

<400>  43

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro 
            20                  25                  30          


Trp Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly 
        35                  40                  45              


Asp Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe 
    50                  55                  60                  


Val Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu 
65                  70                  75                  80  


Ala Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe 
                85                  90                  95      


Arg Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val 
            100                 105                 110         


Arg Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser 
        115                 120                 125             


Leu Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg 
    130                 135                 140                 


Val Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Pro Ser Pro Ser 
145                 150                 155                 160 


Pro Arg Pro Ala Gly Gln Phe Gln Thr Leu Val Phe Trp Leu Pro Ile 
                165                 170                 175     


Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu Ile 
            180                 185                 190         


Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro Asn 
        195                 200                 205             


Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser Arg 
    210                 215                 220                 


Leu Thr Asp Val Thr Leu 
225                 230 


<210>  44
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PD-1 Extracellular Domain; ICOS Transmembrane Domain; ICOS 
       Intracellular Domain

<400>  44
atggccctgc ctgtgacagc tctgctgctg cctcttgctc tgcttctgca tgccgctaga       60

cctccaggct ggttcctgga ctctcccgac agaccttgga accctccaac attcagcccc      120

gctctgctgg tggttaccga gggcgataat gccaccttca cctgtagctt cagcaacacc      180

agcgagagct tcgtgctgaa ctggtacaga atgagcccca gcaaccagac cgacaagctg      240

gccgcctttc ctgaggatag atctcagccc ggccaggact gccggttcag agttacacag      300

ctgcccaacg gccgggactt ccacatgtct gtcgtccggg ccagaagaaa cgacagcggc      360

acatatctgt gcggcgccat ttctctggcc cctaaggctc agatcaaaga gagcctgaga      420

gccgagctga gagtgacaga aagacgggcc gaagtgccca cagctcaccc ttcaccttct      480

ccaagacctg ccggccagtt tcagaccctg gtgttctggc tgcctatcgg ctgtgccgct      540

tttgtggtcg tgtgcatcct gggctgcatc ctgatctgct ggctgaccaa gaaaaagtac      600

agcagcagcg tgcacgaccc caacggcgag tacatgttca tgagagccgt gaacaccgcc      660

aagaagtcca gactgaccga cgtgaccctt                                       690


