                         SEQUENCE LISTING

<110>  ENEA
       ISTITUTI FISIOTERAPICI OSPITALIERI
 
<120>  Plant protein signal sequence as adjuvant in DNA vaccines

<130>  PCT40923

<150>  IT102016000131935
<151>  2016-12-29

<160>  36    

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Phaseolus vulgaris

<400>  1

Met Thr Gln Phe Asn Ile Pro Val Thr Met Ser Ser Ser Leu Ser Ile 
1               5                   10                  15      


Ile Leu Val Ile Leu Val Ser Leu Arg Thr Ala Leu Ser 
            20                  25                  


<210>  2
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  2
ggccggtacc atcatgactc aattcaatat ccaag                                  35


<210>  3
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  3
tgtaggtgta tctccatgca ttgagagtgc agttctcaa                              39


<210>  4
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  4
ttgagaactg cactctcaat gcatggagat acacctaca                              39


<210>  5
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  5
ttctcgactt gcggccgctt atggtttctg agaacagat                              39


<210>  6
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  6
ggccggtacc atcatgactc aattcaatat ccaag                                  35


<210>  7
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  7
ctgtgttgtg ctagctggtg gtttctgaga acagatggg                              39


<210>  8
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  8
atctgttctc agaaaccacc agctagcaca acacagccc                              39


<210>  9
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  9
ttctcgactt gcggccgctt atggtggtgg tagagtgac                              39


<210>  10
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  10
ggccggtacc atcatgactc aattcaatat ccaag                                  35


<210>  11
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  11
gctagctgga ggtccgggtc ctggtttctg agaacagatg gg                          42


<210>  12
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  12
cagaaaccag gacccggacc tccagctagc acaacacagc cc                          42


<210>  13
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  13
ttctcgactt gcggccgctt atggtggtgg tagagtgac                              39


<210>  14
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
ggccggatcc atcatgcgtc acaaacgttc ag                                     32


<210>  15
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
ggccctgcag ttaaaatgta tccatcggaa tt                                     32


<210>  16
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
ggccggatcc atcatgactc aattcaatat ccaag                                  35


<210>  17
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
tgaacgtttg tggacgcatt gagagtgcag ttctcaa                                37


<210>  18
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  18
ttgagaactg cactctcaat gcgtcacaaa cgttca                                 36


<210>  19
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  19
ggccctgcag ttaaaatgta tccatcggaa tt                                     32


<210>  20
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20
ggccggatcc atcatgactc aattcaatat ccaag                                  35


<210>  21
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
tgaacgtttg tggacgcatt gagagtgcag ttctcaa                                37


<210>  22
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22
ttgagaactg cactctcaat gcgtcacaaa cgttca                                 36


<210>  23
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
ggccctgcag ttatggtttc tgagaacaga tg                                     32


<210>  24
<211>  9
<212>  PRT
<213>  Human papillomavirus type 16

<400>  24

Arg Ala His Tyr Asn Ile Val Thr Phe 
1               5                   


<210>  25
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide linker

<400>  25

Gly Pro Gly Pro 
1               


<210>  26
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV16 E7 protein

<400>  26

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  27
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E7GGG (or E7*) protein from HPV16 E7 mutagenenis

<400>  27

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Gly Leu Tyr Gly Tyr Gly Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  28
<211>  201
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV16 L2(1-200) fragment protein optimized for Chlamydomonas 
       rehinardtii codon usage

<400>  28

Met Arg His Lys Arg Ser Ala Lys Arg Thr Lys Arg Ala Ser Ala Thr 
1               5                   10                  15      


Gln Leu Tyr Lys Thr Cys Lys Gln Ala Gly Thr Cys Pro Pro Asp Ile 
            20                  25                  30          


Ile Pro Lys Val Glu Gly Lys Thr Ile Ala Glu Gln Ile Leu Gln Tyr 
        35                  40                  45              


Gly Ser Met Gly Val Phe Phe Gly Gly Leu Gly Ile Gly Thr Gly Ser 
    50                  55                  60                  


Gly Thr Gly Gly Arg Thr Gly Tyr Ile Pro Leu Gly Thr Arg Pro Pro 
65                  70                  75                  80  


Thr Ala Thr Asp Thr Leu Ala Pro Val Arg Pro Pro Leu Thr Val Asp 
                85                  90                  95      


Pro Val Gly Pro Ser Asp Pro Ser Ile Val Ser Leu Val Glu Glu Thr 
            100                 105                 110         


Ser Phe Ile Asp Ala Gly Ala Pro Thr Ser Val Pro Ser Ile Pro Pro 
        115                 120                 125             


Asp Val Ser Gly Phe Ser Ile Thr Thr Ser Thr Asp Thr Thr Pro Ala 
    130                 135                 140                 


Ile Leu Asp Ile Asn Asn Thr Val Thr Thr Val Thr Thr His Asn Asn 
145                 150                 155                 160 


Pro Thr Phe Thr Asp Pro Ser Val Leu Gln Pro Pro Thr Pro Ala Glu 
                165                 170                 175     


Thr Gly Gly His Phe Thr Leu Ser Ser Ser Thr Ile Ser Thr His Asn 
            180                 185                 190         


Tyr Glu Glu Ile Pro Met Asp Thr Phe 
        195                 200     


<210>  29
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CP protein

<400>  29

Met Pro Ala Ser Thr Thr Gln Pro Ile Gly Ser Thr Thr Ser Thr Thr 
1               5                   10                  15      


Thr Lys Thr Ala Gly Ala Thr Pro Ala Thr Ala Ser Gly Leu Phe Thr 
            20                  25                  30          


Ile Pro Asp Gly Asp Phe Phe Ser Thr Ala Arg Ala Ile Val Ala Ser 
        35                  40                  45              


Asn Ala Val Ala Thr Asn Glu Asp Leu Ser Lys Ile Glu Ala Ile Trp 
    50                  55                  60                  


Lys Asp Met Lys Val Pro Thr Asp Thr Met Ala Gln Ala Ala Trp Asp 
65                  70                  75                  80  


Leu Val Arg His Cys Ala Asp Val Gly Ser Ser Ala Gln Thr Glu Met 
                85                  90                  95      


Ile Asp Thr Gly Pro Tyr Ser Asn Gly Ile Ser Arg Ala Arg Leu Ala 
            100                 105                 110         


Ala Ala Ile Lys Glu Val Cys Thr Leu Arg Gln Phe Cys Met Lys Tyr 
        115                 120                 125             


Ala Pro Val Val Trp Asn Trp Met Leu Thr Asn Asn Ser Pro Pro Ala 
    130                 135                 140                 


Asn Trp Gln Ala Gln Gly Phe Lys Pro Glu His Lys Phe Ala Ala Phe 
145                 150                 155                 160 


Asp Phe Phe Asn Gly Val Thr Asn Pro Ala Ala Ile Met Pro Lys Glu 
                165                 170                 175     


Gly Leu Ile Arg Pro Pro Ser Glu Ala Glu Met Asn Ala Ala Gln Thr 
            180                 185                 190         


Ala Ala Phe Val Lys Ile Thr Lys Ala Arg Ala Gln Ser Asn Asp Phe 
        195                 200                 205             


Ala Ser Leu Asp Ala Ala Val Thr Arg Gly Arg Ile Thr Gly Thr Thr 
    210                 215                 220                 


Thr Ala Glu Ala Val Val Thr Leu Pro Pro Pro 
225                 230                 235 


<210>  30
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein obtained by the fusion of SEQ ID NO:1, SEQ ID NO:27 and 
       SEQ ID NO:29

<400>  30

Met Thr Gln Phe Asn Ile Pro Val Thr Met Ser Ser Ser Leu Ser Ile 
1               5                   10                  15      


Ile Leu Val Ile Leu Val Ser Leu Arg Thr Ala Leu Ser His Gly Asp 
            20                  25                  30          


Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr 
        35                  40                  45              


Gly Leu Tyr Gly Tyr Gly Gln Leu Asn Asp Ser Ser Glu Glu Glu Asp 
    50                  55                  60                  


Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr 
65                  70                  75                  80  


Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys 
                85                  90                  95      


Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met 
            100                 105                 110         


Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Pro Ala 
        115                 120                 125             


Ser Thr Thr Gln Pro Ile Gly Ser Thr Thr Ser Thr Thr Thr Lys Thr 
    130                 135                 140                 


Ala Gly Ala Thr Pro Ala Thr Ala Ser Gly Leu Phe Thr Ile Pro Asp 
145                 150                 155                 160 


Gly Asp Phe Phe Ser Thr Ala Arg Ala Ile Val Ala Ser Asn Ala Val 
                165                 170                 175     


Ala Thr Asn Glu Asp Leu Ser Lys Ile Glu Ala Ile Trp Lys Asp Met 
            180                 185                 190         


Lys Val Pro Thr Asp Thr Met Ala Gln Ala Ala Trp Asp Leu Val Arg 
        195                 200                 205             


His Cys Ala Asp Val Gly Ser Ser Ala Gln Thr Glu Met Ile Asp Thr 
    210                 215                 220                 


Gly Pro Tyr Ser Asn Gly Ile Ser Arg Ala Arg Leu Ala Ala Ala Ile 
225                 230                 235                 240 


Lys Glu Val Cys Thr Leu Arg Gln Phe Cys Met Lys Tyr Ala Pro Val 
                245                 250                 255     


Val Trp Asn Trp Met Leu Thr Asn Asn Ser Pro Pro Ala Asn Trp Gln 
            260                 265                 270         


Ala Gln Gly Phe Lys Pro Glu His Lys Phe Ala Ala Phe Asp Phe Phe 
        275                 280                 285             


Asn Gly Val Thr Asn Pro Ala Ala Ile Met Pro Lys Glu Gly Leu Ile 
    290                 295                 300                 


Arg Pro Pro Ser Glu Ala Glu Met Asn Ala Ala Gln Thr Ala Ala Phe 
305                 310                 315                 320 


Val Lys Ile Thr Lys Ala Arg Ala Gln Ser Asn Asp Phe Ala Ser Leu 
                325                 330                 335     


Asp Ala Ala Val Thr Arg Gly Arg Ile Thr Gly Thr Thr Thr Ala Glu 
            340                 345                 350         


Ala Val Val Thr Leu Pro Pro Pro 
        355                 360 


<210>  31
<211>  365
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein obtained by the fusion of SEQ ID NO:1, SEQ ID NO:27, SEQ 
       ID NO:25 and SEQ ID NO:29

<400>  31

Met Thr Gln Phe Asn Ile Pro Val Thr Met Ser Ser Ser Leu Ser Ile 
1               5                   10                  15      


Ile Leu Val Ile Leu Val Ser Leu Arg Thr Ala Leu Ser Met His Gly 
            20                  25                  30          


Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr 
        35                  40                  45              


Thr Gly Leu Tyr Gly Tyr Gly Gln Leu Asn Asp Ser Ser Glu Glu Glu 
    50                  55                  60                  


Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His 
65                  70                  75                  80  


Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu 
                85                  90                  95      


Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu 
            100                 105                 110         


Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Gly 
        115                 120                 125             


Pro Gly Pro Pro Ala Ser Thr Thr Gln Pro Ile Gly Ser Thr Thr Ser 
    130                 135                 140                 


Thr Thr Thr Lys Thr Ala Gly Ala Thr Pro Ala Thr Ala Ser Gly Leu 
145                 150                 155                 160 


Phe Thr Ile Pro Asp Gly Asp Phe Phe Ser Thr Ala Arg Ala Ile Val 
                165                 170                 175     


Ala Ser Asn Ala Val Ala Thr Asn Glu Asp Leu Ser Lys Ile Glu Ala 
            180                 185                 190         


Ile Trp Lys Asp Met Lys Val Pro Thr Asp Thr Met Ala Gln Ala Ala 
        195                 200                 205             


Trp Asp Leu Val Arg His Cys Ala Asp Val Gly Ser Ser Ala Gln Thr 
    210                 215                 220                 


Glu Met Ile Asp Thr Gly Pro Tyr Ser Asn Gly Ile Ser Arg Ala Arg 
225                 230                 235                 240 


Leu Ala Ala Ala Ile Lys Glu Val Cys Thr Leu Arg Gln Phe Cys Met 
                245                 250                 255     


Lys Tyr Ala Pro Val Val Trp Asn Trp Met Leu Thr Asn Asn Ser Pro 
            260                 265                 270         


Pro Ala Asn Trp Gln Ala Gln Gly Phe Lys Pro Glu His Lys Phe Ala 
        275                 280                 285             


Ala Phe Asp Phe Phe Asn Gly Val Thr Asn Pro Ala Ala Ile Met Pro 
    290                 295                 300                 


Lys Glu Gly Leu Ile Arg Pro Pro Ser Glu Ala Glu Met Asn Ala Ala 
305                 310                 315                 320 


Gln Thr Ala Ala Phe Val Lys Ile Thr Lys Ala Arg Ala Gln Ser Asn 
                325                 330                 335     


Asp Phe Ala Ser Leu Asp Ala Ala Val Thr Arg Gly Arg Ile Thr Gly 
            340                 345                 350         


Thr Thr Thr Ala Glu Ala Val Val Thr Leu Pro Pro Pro 
        355                 360                 365 


<210>  32
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein obtained by the fusion of SEQ ID NO:1, SEQ ID NO:28 and 
       SEQ ID NO:26

<400>  32

Met Thr Gln Phe Asn Ile Pro Val Thr Met Ser Ser Ser Leu Ser Ile 
1               5                   10                  15      


Ile Leu Val Ile Leu Val Ser Leu Arg Thr Ala Leu Ser Arg His Lys 
            20                  25                  30          


Arg Ser Ala Lys Arg Thr Lys Arg Ala Ser Ala Thr Gln Leu Tyr Lys 
        35                  40                  45              


Thr Cys Lys Gln Ala Gly Thr Cys Pro Pro Asp Ile Ile Pro Lys Val 
    50                  55                  60                  


Glu Gly Lys Thr Ile Ala Glu Gln Ile Leu Gln Tyr Gly Ser Met Gly 
65                  70                  75                  80  


Val Phe Phe Gly Gly Leu Gly Ile Gly Thr Gly Ser Gly Thr Gly Gly 
                85                  90                  95      


Arg Thr Gly Tyr Ile Pro Leu Gly Thr Arg Pro Pro Thr Ala Thr Asp 
            100                 105                 110         


Thr Leu Ala Pro Val Arg Pro Pro Leu Thr Val Asp Pro Val Gly Pro 
        115                 120                 125             


Ser Asp Pro Ser Ile Val Ser Leu Val Glu Glu Thr Ser Phe Ile Asp 
    130                 135                 140                 


Ala Gly Ala Pro Thr Ser Val Pro Ser Ile Pro Pro Asp Val Ser Gly 
145                 150                 155                 160 


Phe Ser Ile Thr Thr Ser Thr Asp Thr Thr Pro Ala Ile Leu Asp Ile 
                165                 170                 175     


Asn Asn Thr Val Thr Thr Val Thr Thr His Asn Asn Pro Thr Phe Thr 
            180                 185                 190         


Asp Pro Ser Val Leu Gln Pro Pro Thr Pro Ala Glu Thr Gly Gly His 
        195                 200                 205             


Phe Thr Leu Ser Ser Ser Thr Ile Ser Thr His Asn Tyr Glu Glu Ile 
    210                 215                 220                 


Pro Met Asp Thr Phe His Gly Asp Thr Pro Thr Leu His Glu Tyr Met 
225                 230                 235                 240 


Leu Asp Leu Gln Pro Glu Thr Thr Gly Leu Tyr Gly Tyr Gly Gln Leu 
                245                 250                 255     


Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln 
            260                 265                 270         


Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys 
        275                 280                 285             


Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile 
    290                 295                 300                 


Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
305                 310                 315                 320 


Ile Cys Ser Gln Lys Pro 
                325     


<210>  33
<211>  332
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein obtained by the fusion of SEQ ID NO:27 and SEQ ID NO:29

<400>  33

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Gly Leu Tyr Gly Tyr Gly Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro Pro Ala Ser Thr Thr Gln Pro Ile Gly Ser Thr Thr Ser Thr 
            100                 105                 110         


Thr Thr Lys Thr Ala Gly Ala Thr Pro Ala Thr Ala Ser Gly Leu Phe 
        115                 120                 125             


Thr Ile Pro Asp Gly Asp Phe Phe Ser Thr Ala Arg Ala Ile Val Ala 
    130                 135                 140                 


Ser Asn Ala Val Ala Thr Asn Glu Asp Leu Ser Lys Ile Glu Ala Ile 
145                 150                 155                 160 


Trp Lys Asp Met Lys Val Pro Thr Asp Thr Met Ala Gln Ala Ala Trp 
                165                 170                 175     


Asp Leu Val Arg His Cys Ala Asp Val Gly Ser Ser Ala Gln Thr Glu 
            180                 185                 190         


Met Ile Asp Thr Gly Pro Tyr Ser Asn Gly Ile Ser Arg Ala Arg Leu 
        195                 200                 205             


Ala Ala Ala Ile Lys Glu Val Cys Thr Leu Arg Gln Phe Cys Met Lys 
    210                 215                 220                 


Tyr Ala Pro Val Val Trp Asn Trp Met Leu Thr Asn Asn Ser Pro Pro 
225                 230                 235                 240 


Ala Asn Trp Gln Ala Gln Gly Phe Lys Pro Glu His Lys Phe Ala Ala 
                245                 250                 255     


Phe Asp Phe Phe Asn Gly Val Thr Asn Pro Ala Ala Ile Met Pro Lys 
            260                 265                 270         


Glu Gly Leu Ile Arg Pro Pro Ser Glu Ala Glu Met Asn Ala Ala Gln 
        275                 280                 285             


Thr Ala Ala Phe Val Lys Ile Thr Lys Ala Arg Ala Gln Ser Asn Asp 
    290                 295                 300                 


Phe Ala Ser Leu Asp Ala Ala Val Thr Arg Gly Arg Ile Thr Gly Thr 
305                 310                 315                 320 


Thr Thr Ala Glu Ala Val Val Thr Leu Pro Pro Pro 
                325                 330         


<210>  34
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein obtained by the fusion of SEQ ID NO:27, SEQ ID NO:25 and 
       SEQ ID NO:29

<400>  34

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Gly Leu Tyr Gly Tyr Gly Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro Gly Pro Gly Pro Pro Ala Ser Thr Thr Gln Pro Ile Gly Ser 
            100                 105                 110         


Thr Thr Ser Thr Thr Thr Lys Thr Ala Gly Ala Thr Pro Ala Thr Ala 
        115                 120                 125             


Ser Gly Leu Phe Thr Ile Pro Asp Gly Asp Phe Phe Ser Thr Ala Arg 
    130                 135                 140                 


Ala Ile Val Ala Ser Asn Ala Val Ala Thr Asn Glu Asp Leu Ser Lys 
145                 150                 155                 160 


Ile Glu Ala Ile Trp Lys Asp Met Lys Val Pro Thr Asp Thr Met Ala 
                165                 170                 175     


Gln Ala Ala Trp Asp Leu Val Arg His Cys Ala Asp Val Gly Ser Ser 
            180                 185                 190         


Ala Gln Thr Glu Met Ile Asp Thr Gly Pro Tyr Ser Asn Gly Ile Ser 
        195                 200                 205             


Arg Ala Arg Leu Ala Ala Ala Ile Lys Glu Val Cys Thr Leu Arg Gln 
    210                 215                 220                 


Phe Cys Met Lys Tyr Ala Pro Val Val Trp Asn Trp Met Leu Thr Asn 
225                 230                 235                 240 


Asn Ser Pro Pro Ala Asn Trp Gln Ala Gln Gly Phe Lys Pro Glu His 
                245                 250                 255     


Lys Phe Ala Ala Phe Asp Phe Phe Asn Gly Val Thr Asn Pro Ala Ala 
            260                 265                 270         


Ile Met Pro Lys Glu Gly Leu Ile Arg Pro Pro Ser Glu Ala Glu Met 
        275                 280                 285             


Asn Ala Ala Gln Thr Ala Ala Phe Val Lys Ile Thr Lys Ala Arg Ala 
    290                 295                 300                 


Gln Ser Asn Asp Phe Ala Ser Leu Asp Ala Ala Val Thr Arg Gly Arg 
305                 310                 315                 320 


Ile Thr Gly Thr Thr Thr Ala Glu Ala Val Val Thr Leu Pro Pro Pro 
                325                 330                 335     


<210>  35
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein obtained by the fusion of SEQ ID NO:1 and SEQ ID NO:27

<400>  35

Met Thr Gln Phe Asn Ile Pro Val Thr Met Ser Ser Ser Leu Ser Ile 
1               5                   10                  15      


Ile Leu Val Ile Leu Val Ser Leu Arg Thr Ala Leu Ser Met His Gly 
            20                  25                  30          


Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr 
        35                  40                  45              


Thr Gly Leu Tyr Gly Tyr Gly Gln Leu Asn Asp Ser Ser Glu Glu Glu 
    50                  55                  60                  


Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His 
65                  70                  75                  80  


Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu 
                85                  90                  95      


Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu 
            100                 105                 110         


Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro 
        115                 120                 125         


<210>  36
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein obtained by the fusion of SEQ ID NO:1 and SEQ ID NO:28

<400>  36

Met Thr Gln Phe Asn Ile Pro Val Thr Met Ser Ser Ser Leu Ser Ile 
1               5                   10                  15      


Ile Leu Val Ile Leu Val Ser Leu Arg Thr Ala Leu Ser Arg His Lys 
            20                  25                  30          


Arg Ser Ala Lys Arg Thr Lys Arg Ala Ser Ala Thr Gln Leu Tyr Lys 
        35                  40                  45              


Thr Cys Lys Gln Ala Gly Thr Cys Pro Pro Asp Ile Ile Pro Lys Val 
    50                  55                  60                  


Glu Gly Lys Thr Ile Ala Glu Gln Ile Leu Gln Tyr Gly Ser Met Gly 
65                  70                  75                  80  


Val Phe Phe Gly Gly Leu Gly Ile Gly Thr Gly Ser Gly Thr Gly Gly 
                85                  90                  95      


Arg Thr Gly Tyr Ile Pro Leu Gly Thr Arg Pro Pro Thr Ala Thr Asp 
            100                 105                 110         


Thr Leu Ala Pro Val Arg Pro Pro Leu Thr Val Asp Pro Val Gly Pro 
        115                 120                 125             


Ser Asp Pro Ser Ile Val Ser Leu Val Glu Glu Thr Ser Phe Ile Asp 
    130                 135                 140                 


Ala Gly Ala Pro Thr Ser Val Pro Ser Ile Pro Pro Asp Val Ser Gly 
145                 150                 155                 160 


Phe Ser Ile Thr Thr Ser Thr Asp Thr Thr Pro Ala Ile Leu Asp Ile 
                165                 170                 175     


Asn Asn Thr Val Thr Thr Val Thr Thr His Asn Asn Pro Thr Phe Thr 
            180                 185                 190         


Asp Pro Ser Val Leu Gln Pro Pro Thr Pro Ala Glu Thr Gly Gly His 
        195                 200                 205             


Phe Thr Leu Ser Ser Ser Thr Ile Ser Thr His Asn Tyr Glu Glu Ile 
    210                 215                 220                 


Pro Met Asp Thr Phe 
225                 


