                         SEQUENCE LISTING

<110>  PhaseRx, Inc.
 
<120>  Branched PEG Molecules and Related Compositions and Methods

<130>  4100.PRV1

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Phe Asn Leu Arg Ile Leu Leu Asn Asn Ala Ala Phe Arg Asn 
1               5                   10                  15      


Gly His Asn Phe Met Val Arg Asn Phe Arg Cys Gly Gln Pro Leu Gln 
            20                  25                  30          


Asn Lys Val Gln Leu Lys Gly Arg Asp Leu Leu Thr Leu Lys Asn Phe 
        35                  40                  45              


Thr Gly Glu Glu Ile Lys Tyr Met Leu Trp Leu Ser Ala Asp Leu Lys 
    50                  55                  60                  


Phe Arg Ile Lys Gln Lys Gly Glu Tyr Leu Pro Leu Leu Gln Gly Lys 
65                  70                  75                  80  


Ser Leu Gly Met Ile Phe Glu Lys Arg Ser Thr Arg Thr Arg Leu Ser 
                85                  90                  95      


Thr Glu Thr Gly Phe Ala Leu Leu Gly Gly His Pro Cys Phe Leu Thr 
            100                 105                 110         


Thr Gln Asp Ile His Leu Gly Val Asn Glu Ser Leu Thr Asp Thr Ala 
        115                 120                 125             


Arg Val Leu Ser Ser Met Ala Asp Ala Val Leu Ala Arg Val Tyr Lys 
    130                 135                 140                 


Gln Ser Asp Leu Asp Thr Leu Ala Lys Glu Ala Ser Ile Pro Ile Ile 
145                 150                 155                 160 


Asn Gly Leu Ser Asp Leu Tyr His Pro Ile Gln Ile Leu Ala Asp Tyr 
                165                 170                 175     


Leu Thr Leu Gln Glu His Tyr Ser Ser Leu Lys Gly Leu Thr Leu Ser 
            180                 185                 190         


Trp Ile Gly Asp Gly Asn Asn Ile Leu His Ser Ile Met Met Ser Ala 
        195                 200                 205             


Ala Lys Phe Gly Met His Leu Gln Ala Ala Thr Pro Lys Gly Tyr Glu 
    210                 215                 220                 


Pro Asp Ala Ser Val Thr Lys Leu Ala Glu Gln Tyr Ala Lys Glu Asn 
225                 230                 235                 240 


Gly Thr Lys Leu Leu Leu Thr Asn Asp Pro Leu Glu Ala Ala His Gly 
                245                 250                 255     


Gly Asn Val Leu Ile Thr Asp Thr Trp Ile Ser Met Gly Gln Glu Glu 
            260                 265                 270         


Glu Lys Lys Lys Arg Leu Gln Ala Phe Gln Gly Tyr Gln Val Thr Met 
        275                 280                 285             


Lys Thr Ala Lys Val Ala Ala Ser Asp Trp Thr Phe Leu His Cys Leu 
    290                 295                 300                 


Pro Arg Lys Pro Glu Glu Val Asp Asp Glu Val Phe Tyr Ser Pro Arg 
305                 310                 315                 320 


Ser Leu Val Phe Pro Glu Ala Glu Asn Arg Lys Trp Thr Ile Met Ala 
                325                 330                 335     


Val Met Val Ser Leu Leu Thr Asp Tyr Ser Pro Gln Leu Gln Lys Pro 
            340                 345                 350         


Lys Phe 
        


<210>  2
<211>  464
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Glu Ser Gly Lys Leu Trp Gly Gly Arg Phe Val Gly Ala 
1               5                   10                  15      


Val Asp Pro Ile Met Glu Lys Phe Asn Ala Ser Ile Ala Tyr Asp Arg 
            20                  25                  30          


His Leu Trp Glu Val Asp Val Gln Gly Ser Lys Ala Tyr Ser Arg Gly 
        35                  40                  45              


Leu Glu Lys Ala Gly Leu Leu Thr Lys Ala Glu Met Asp Gln Ile Leu 
    50                  55                  60                  


His Gly Leu Asp Lys Val Ala Glu Glu Trp Ala Gln Gly Thr Phe Lys 
65                  70                  75                  80  


Leu Asn Ser Asn Asp Glu Asp Ile His Thr Ala Asn Glu Arg Arg Leu 
                85                  90                  95      


Lys Glu Leu Ile Gly Ala Thr Ala Gly Lys Leu His Thr Gly Arg Ser 
            100                 105                 110         


Arg Asn Asp Gln Val Val Thr Asp Leu Arg Leu Trp Met Arg Gln Thr 
        115                 120                 125             


Cys Ser Thr Leu Ser Gly Leu Leu Trp Glu Leu Ile Arg Thr Met Val 
    130                 135                 140                 


Asp Arg Ala Glu Ala Glu Arg Asp Val Leu Phe Pro Gly Tyr Thr His 
145                 150                 155                 160 


Leu Gln Arg Ala Gln Pro Ile Arg Trp Ser His Trp Ile Leu Ser His 
                165                 170                 175     


Ala Val Ala Leu Thr Arg Asp Ser Glu Arg Leu Leu Glu Val Arg Lys 
            180                 185                 190         


Arg Ile Asn Val Leu Pro Leu Gly Ser Gly Ala Ile Ala Gly Asn Pro 
        195                 200                 205             


Leu Gly Val Asp Arg Glu Leu Leu Arg Ala Glu Leu Asn Phe Gly Ala 
    210                 215                 220                 


Ile Thr Leu Asn Ser Met Asp Ala Thr Ser Glu Arg Asp Phe Val Ala 
225                 230                 235                 240 


Glu Phe Leu Phe Trp Ala Ser Leu Cys Met Thr His Leu Ser Arg Met 
                245                 250                 255     


Ala Glu Asp Leu Ile Leu Tyr Cys Thr Lys Glu Phe Ser Phe Val Gln 
            260                 265                 270         


Leu Ser Asp Ala Tyr Ser Thr Gly Ser Ser Leu Met Pro Gln Lys Lys 
        275                 280                 285             


Asn Pro Asp Ser Leu Glu Leu Ile Arg Ser Lys Ala Gly Arg Val Phe 
    290                 295                 300                 


Gly Arg Cys Ala Gly Leu Leu Met Thr Leu Lys Gly Leu Pro Ser Thr 
305                 310                 315                 320 


Tyr Asn Lys Asp Leu Gln Glu Asp Lys Glu Ala Val Phe Glu Val Ser 
                325                 330                 335     


Asp Thr Met Ser Ala Val Leu Gln Val Ala Thr Gly Val Ile Ser Thr 
            340                 345                 350         


Leu Gln Ile His Gln Glu Asn Met Gly Gln Ala Leu Ser Pro Asp Met 
        355                 360                 365             


Leu Ala Thr Asp Leu Ala Tyr Tyr Leu Val Arg Lys Gly Met Pro Phe 
    370                 375                 380                 


Arg Gln Ala His Glu Ala Ser Gly Lys Ala Val Phe Met Ala Glu Thr 
385                 390                 395                 400 


Lys Gly Val Ala Leu Asn Gln Leu Ser Leu Gln Glu Leu Gln Thr Ile 
                405                 410                 415     


Ser Pro Leu Phe Ser Gly Asp Val Ile Cys Val Trp Asp Tyr Gly His 
            420                 425                 430         


Ser Val Glu Gln Tyr Gly Ala Leu Gly Gly Thr Ala Arg Ser Ser Val 
        435                 440                 445             


Asp Trp Gln Ile Arg Gln Val Arg Ala Leu Leu Gln Ala Gln Gln Ala 
    450                 455                 460                 


<210>  3
<211>  412
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Ser Lys Gly Ser Val Val Leu Ala Tyr Ser Gly Gly Leu Asp 
1               5                   10                  15      


Thr Ser Cys Ile Leu Val Trp Leu Lys Glu Gln Gly Tyr Asp Val Ile 
            20                  25                  30          


Ala Tyr Leu Ala Asn Ile Gly Gln Lys Glu Asp Phe Glu Glu Ala Arg 
        35                  40                  45              


Lys Lys Ala Leu Lys Leu Gly Ala Lys Lys Val Phe Ile Glu Asp Val 
    50                  55                  60                  


Ser Arg Glu Phe Val Glu Glu Phe Ile Trp Pro Ala Ile Gln Ser Ser 
65                  70                  75                  80  


Ala Leu Tyr Glu Asp Arg Tyr Leu Leu Gly Thr Ser Leu Ala Arg Pro 
                85                  90                  95      


Cys Ile Ala Arg Lys Gln Val Glu Ile Ala Gln Arg Glu Gly Ala Lys 
            100                 105                 110         


Tyr Val Ser His Gly Ala Thr Gly Lys Gly Asn Asp Gln Val Arg Phe 
        115                 120                 125             


Glu Leu Ser Cys Tyr Ser Leu Ala Pro Gln Ile Lys Val Ile Ala Pro 
    130                 135                 140                 


Trp Arg Met Pro Glu Phe Tyr Asn Arg Phe Lys Gly Arg Asn Asp Leu 
145                 150                 155                 160 


Met Glu Tyr Ala Lys Gln His Gly Ile Pro Ile Pro Val Thr Pro Lys 
                165                 170                 175     


Asn Pro Trp Ser Met Asp Glu Asn Leu Met His Ile Ser Tyr Glu Ala 
            180                 185                 190         


Gly Ile Leu Glu Asn Pro Lys Asn Gln Ala Pro Pro Gly Leu Tyr Thr 
        195                 200                 205             


Lys Thr Gln Asp Pro Ala Lys Ala Pro Asn Thr Pro Asp Ile Leu Glu 
    210                 215                 220                 


Ile Glu Phe Lys Lys Gly Val Pro Val Lys Val Thr Asn Val Lys Asp 
225                 230                 235                 240 


Gly Thr Thr His Gln Thr Ser Leu Glu Leu Phe Met Tyr Leu Asn Glu 
                245                 250                 255     


Val Ala Gly Lys His Gly Val Gly Arg Ile Asp Ile Val Glu Asn Arg 
            260                 265                 270         


Phe Ile Gly Met Lys Ser Arg Gly Ile Tyr Glu Thr Pro Ala Gly Thr 
        275                 280                 285             


Ile Leu Tyr His Ala His Leu Asp Ile Glu Ala Phe Thr Met Asp Arg 
    290                 295                 300                 


Glu Val Arg Lys Ile Lys Gln Gly Leu Gly Leu Lys Phe Ala Glu Leu 
305                 310                 315                 320 


Val Tyr Thr Gly Phe Trp His Ser Pro Glu Cys Glu Phe Val Arg His 
                325                 330                 335     


Cys Ile Ala Lys Ser Gln Glu Arg Val Glu Gly Lys Val Gln Val Ser 
            340                 345                 350         


Val Leu Lys Gly Gln Val Tyr Ile Leu Gly Arg Glu Ser Pro Leu Ser 
        355                 360                 365             


Leu Tyr Asn Glu Glu Leu Val Ser Met Asn Val Gln Gly Asp Tyr Glu 
    370                 375                 380                 


Pro Thr Asp Ala Thr Gly Phe Ile Asn Ile Asn Ser Leu Arg Leu Lys 
385                 390                 395                 400 


Glu Tyr His Arg Leu Gln Ser Lys Val Thr Ala Lys 
                405                 410         


<210>  4
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Arg Ala Lys Asn Gln Leu Phe Leu Leu Ser Pro His Tyr Leu 
1               5                   10                  15      


Arg Gln Val Lys Glu Ser Ser Gly Ser Arg Leu Ile Gln Gln Arg Leu 
            20                  25                  30          


Leu His Gln Gln Gln Pro Leu His Pro Glu Trp Ala Ala Leu Ala Lys 
        35                  40                  45              


Lys Gln Leu Lys Gly Lys Asn Pro Glu Asp Leu Ile Trp His Thr Pro 
    50                  55                  60                  


Glu Gly Ile Ser Ile Lys Pro Leu Tyr Ser Lys Arg Asp Thr Met Asp 
65                  70                  75                  80  


Leu Pro Glu Glu Leu Pro Gly Val Lys Pro Phe Thr Arg Gly Pro Tyr 
                85                  90                  95      


Pro Thr Met Tyr Thr Phe Arg Pro Trp Thr Ile Arg Gln Tyr Ala Gly 
            100                 105                 110         


Phe Ser Thr Val Glu Glu Ser Asn Lys Phe Tyr Lys Asp Asn Ile Lys 
        115                 120                 125             


Ala Gly Gln Gln Gly Leu Ser Val Ala Phe Asp Leu Ala Thr His Arg 
    130                 135                 140                 


Gly Tyr Asp Ser Asp Asn Pro Arg Val Arg Gly Asp Val Gly Met Ala 
145                 150                 155                 160 


Gly Val Ala Ile Asp Thr Val Glu Asp Thr Lys Ile Leu Phe Asp Gly 
                165                 170                 175     


Ile Pro Leu Glu Lys Met Ser Val Ser Met Thr Met Asn Gly Ala Val 
            180                 185                 190         


Ile Pro Val Leu Ala Asn Phe Ile Val Thr Gly Glu Glu Gln Gly Val 
        195                 200                 205             


Pro Lys Glu Lys Leu Thr Gly Thr Ile Gln Asn Asp Ile Leu Lys Glu 
    210                 215                 220                 


Phe Met Val Arg Asn Thr Tyr Ile Phe Pro Pro Glu Pro Ser Met Lys 
225                 230                 235                 240 


Ile Ile Ala Asp Ile Phe Glu Tyr Thr Ala Lys His Met Pro Lys Phe 
                245                 250                 255     


Asn Ser Ile Ser Ile Ser Gly Tyr His Met Gln Glu Ala Gly Ala Asp 
            260                 265                 270         


Ala Ile Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Leu Glu Tyr Ser 
        275                 280                 285             


Arg Thr Gly Leu Gln Ala Gly Leu Thr Ile Asp Glu Phe Ala Pro Arg 
    290                 295                 300                 


Leu Ser Phe Phe Trp Gly Ile Gly Met Asn Phe Tyr Met Glu Ile Ala 
305                 310                 315                 320 


Lys Met Arg Ala Gly Arg Arg Leu Trp Ala His Leu Ile Glu Lys Met 
                325                 330                 335     


Phe Gln Pro Lys Asn Ser Lys Ser Leu Leu Leu Arg Ala His Cys Gln 
            340                 345                 350         


Thr Ser Gly Trp Ser Leu Thr Glu Gln Asp Pro Tyr Asn Asn Ile Val 
        355                 360                 365             


Arg Thr Ala Ile Glu Ala Met Ala Ala Val Phe Gly Gly Thr Gln Ser 
    370                 375                 380                 


Leu His Thr Asn Ser Phe Asp Glu Ala Leu Gly Leu Pro Thr Val Lys 
385                 390                 395                 400 


Ser Ala Arg Ile Ala Arg Asn Thr Gln Ile Ile Ile Gln Glu Glu Ser 
                405                 410                 415     


Gly Ile Pro Lys Val Ala Asp Pro Trp Gly Gly Ser Tyr Met Met Glu 
            420                 425                 430         


Cys Leu Thr Asn Asp Val Tyr Asp Ala Ala Leu Lys Leu Ile Asn Glu 
        435                 440                 445             


Ile Glu Glu Met Gly Gly Met Ala Lys Ala Val Ala Glu Gly Ile Pro 
    450                 455                 460                 


Lys Leu Arg Ile Glu Glu Cys Ala Ala Arg Arg Gln Ala Arg Ile Asp 
465                 470                 475                 480 


Ser Gly Ser Glu Val Ile Val Gly Val Asn Lys Tyr Gln Leu Glu Lys 
                485                 490                 495     


Glu Asp Ala Val Glu Val Leu Ala Ile Asp Asn Thr Ser Val Arg Asn 
            500                 505                 510         


Arg Gln Ile Glu Lys Leu Lys Lys Ile Lys Ser Ser Arg Asp Gln Ala 
        515                 520                 525             


Leu Ala Glu Arg Cys Leu Ala Ala Leu Thr Glu Cys Ala Ala Ser Gly 
    530                 535                 540                 


Asp Gly Asn Ile Leu Ala Leu Ala Val Asp Ala Ser Arg Ala Arg Cys 
545                 550                 555                 560 


Thr Val Gly Glu Ile Thr Asp Ala Leu Lys Lys Val Phe Gly Glu His 
                565                 570                 575     


Lys Ala Asn Asp Arg Met Val Ser Gly Ala Tyr Arg Gln Glu Phe Gly 
            580                 585                 590         


Glu Ser Lys Glu Ile Thr Ser Ala Ile Lys Arg Val His Lys Phe Met 
        595                 600                 605             


Glu Arg Glu Gly Arg Arg Pro Arg Leu Leu Val Ala Lys Met Gly Gln 
    610                 615                 620                 


Asp Gly His Asp Arg Gly Ala Lys Val Ile Ala Thr Gly Phe Ala Asp 
625                 630                 635                 640 


Leu Gly Phe Asp Val Asp Ile Gly Pro Leu Phe Gln Thr Pro Arg Glu 
                645                 650                 655     


Val Ala Gln Gln Ala Val Asp Ala Asp Val His Ala Val Gly Ile Ser 
            660                 665                 670         


Thr Leu Ala Ala Gly His Lys Thr Leu Val Pro Glu Leu Ile Lys Glu 
        675                 680                 685             


Leu Asn Ser Leu Gly Arg Pro Asp Ile Leu Val Met Cys Gly Gly Val 
    690                 695                 700                 


Ile Pro Pro Gln Asp Tyr Glu Phe Leu Phe Glu Val Gly Val Ser Asn 
705                 710                 715                 720 


Val Phe Gly Pro Gly Thr Arg Ile Pro Lys Ala Ala Val Gln Val Leu 
                725                 730                 735     


Asp Asp Ile Glu Lys Cys Leu Glu Lys Lys Gln Gln Ser Val 
            740                 745                 750 


<210>  5
<211>  728
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Gly Phe Trp Val Gly Thr Ala Pro Leu Val Ala Ala Gly Arg 
1               5                   10                  15      


Arg Gly Arg Trp Pro Pro Gln Gln Leu Met Leu Ser Ala Ala Leu Arg 
            20                  25                  30          


Thr Leu Lys His Val Leu Tyr Tyr Ser Arg Gln Cys Leu Met Val Ser 
        35                  40                  45              


Arg Asn Leu Gly Ser Val Gly Tyr Asp Pro Asn Glu Lys Thr Phe Asp 
    50                  55                  60                  


Lys Ile Leu Val Ala Asn Arg Gly Glu Ile Ala Cys Arg Val Ile Arg 
65                  70                  75                  80  


Thr Cys Lys Lys Met Gly Ile Lys Thr Val Ala Ile His Ser Asp Val 
                85                  90                  95      


Asp Ala Ser Ser Val His Val Lys Met Ala Asp Glu Ala Val Cys Val 
            100                 105                 110         


Gly Pro Ala Pro Thr Ser Lys Ser Tyr Leu Asn Met Asp Ala Ile Met 
        115                 120                 125             


Glu Ala Ile Lys Lys Thr Arg Ala Gln Ala Val His Pro Gly Tyr Gly 
    130                 135                 140                 


Phe Leu Ser Glu Asn Lys Glu Phe Ala Arg Cys Leu Ala Ala Glu Asp 
145                 150                 155                 160 


Val Val Phe Ile Gly Pro Asp Thr His Ala Ile Gln Ala Met Gly Asp 
                165                 170                 175     


Lys Ile Glu Ser Lys Leu Leu Ala Lys Lys Ala Glu Val Asn Thr Ile 
            180                 185                 190         


Pro Gly Phe Asp Gly Val Val Lys Asp Ala Glu Glu Ala Val Arg Ile 
        195                 200                 205             


Ala Arg Glu Ile Gly Tyr Pro Val Met Ile Lys Ala Ser Ala Gly Gly 
    210                 215                 220                 


Gly Gly Lys Gly Met Arg Ile Ala Trp Asp Asp Glu Glu Thr Arg Asp 
225                 230                 235                 240 


Gly Phe Arg Leu Ser Ser Gln Glu Ala Ala Ser Ser Phe Gly Asp Asp 
                245                 250                 255     


Arg Leu Leu Ile Glu Lys Phe Ile Asp Asn Pro Arg His Ile Glu Ile 
            260                 265                 270         


Gln Val Leu Gly Asp Lys His Gly Asn Ala Leu Trp Leu Asn Glu Arg 
        275                 280                 285             


Glu Cys Ser Ile Gln Arg Arg Asn Gln Lys Val Val Glu Glu Ala Pro 
    290                 295                 300                 


Ser Ile Phe Leu Asp Ala Glu Thr Arg Arg Ala Met Gly Glu Gln Ala 
305                 310                 315                 320 


Val Ala Leu Ala Arg Ala Val Lys Tyr Ser Ser Ala Gly Thr Val Glu 
                325                 330                 335     


Phe Leu Val Asp Ser Lys Lys Asn Phe Tyr Phe Leu Glu Met Asn Thr 
            340                 345                 350         


Arg Leu Gln Val Glu His Pro Val Thr Glu Cys Ile Thr Gly Leu Asp 
        355                 360                 365             


Leu Val Gln Glu Met Ile Arg Val Ala Lys Gly Tyr Pro Leu Arg His 
    370                 375                 380                 


Lys Gln Ala Asp Ile Arg Ile Asn Gly Trp Ala Val Glu Cys Arg Val 
385                 390                 395                 400 


Tyr Ala Glu Asp Pro Tyr Lys Ser Phe Gly Leu Pro Ser Ile Gly Arg 
                405                 410                 415     


Leu Ser Gln Tyr Gln Glu Pro Leu His Leu Pro Gly Val Arg Val Asp 
            420                 425                 430         


Ser Gly Ile Gln Pro Gly Ser Asp Ile Ser Ile Tyr Tyr Asp Pro Met 
        435                 440                 445             


Ile Ser Lys Leu Ile Thr Tyr Gly Ser Asp Arg Thr Glu Ala Leu Lys 
    450                 455                 460                 


Arg Met Ala Asp Ala Leu Asp Asn Tyr Val Ile Arg Gly Val Thr His 
465                 470                 475                 480 


Asn Ile Ala Leu Leu Arg Glu Val Ile Ile Asn Ser Arg Phe Val Lys 
                485                 490                 495     


Gly Asp Ile Ser Thr Lys Phe Leu Ser Asp Val Tyr Pro Asp Gly Phe 
            500                 505                 510         


Lys Gly His Met Leu Thr Lys Ser Glu Lys Asn Gln Leu Leu Ala Ile 
        515                 520                 525             


Ala Ser Ser Leu Phe Val Ala Phe Gln Leu Arg Ala Gln His Phe Gln 
    530                 535                 540                 


Glu Asn Ser Arg Met Pro Val Ile Lys Pro Asp Ile Ala Asn Trp Glu 
545                 550                 555                 560 


Leu Ser Val Lys Leu His Asp Lys Val His Thr Val Val Ala Ser Asn 
                565                 570                 575     


Asn Gly Ser Val Phe Ser Val Glu Val Asp Gly Ser Lys Leu Asn Val 
            580                 585                 590         


Thr Ser Thr Trp Asn Leu Ala Ser Pro Leu Leu Ser Val Ser Val Asp 
        595                 600                 605             


Gly Thr Gln Arg Thr Val Gln Cys Leu Ser Arg Glu Ala Gly Gly Asn 
    610                 615                 620                 


Met Ser Ile Gln Phe Leu Gly Thr Val Tyr Lys Val Asn Ile Leu Thr 
625                 630                 635                 640 


Arg Leu Ala Ala Glu Leu Asn Lys Phe Met Leu Glu Lys Val Thr Glu 
                645                 650                 655     


Asp Thr Ser Ser Val Leu Arg Ser Pro Met Pro Gly Val Val Val Ala 
            660                 665                 670         


Val Ser Val Lys Pro Gly Asp Ala Val Ala Glu Gly Gln Glu Ile Cys 
        675                 680                 685             


Val Ile Glu Ala Met Lys Met Gln Asn Ser Met Thr Ala Gly Lys Thr 
    690                 695                 700                 


Gly Thr Val Lys Ser Val His Cys Gln Ala Gly Asp Thr Val Gly Glu 
705                 710                 715                 720 


Gly Asp Leu Leu Val Glu Leu Glu 
                725             


<210>  6
<211>  539
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Ala Leu Arg Val Ala Ala Val Gly Ala Arg Leu Ser Val 
1               5                   10                  15      


Leu Ala Ser Gly Leu Arg Ala Ala Val Arg Ser Leu Cys Ser Gln Ala 
            20                  25                  30          


Thr Ser Val Asn Glu Arg Ile Glu Asn Lys Arg Arg Thr Ala Leu Leu 
        35                  40                  45              


Gly Gly Gly Gln Arg Arg Ile Asp Ala Gln His Lys Arg Gly Lys Leu 
    50                  55                  60                  


Thr Ala Arg Glu Arg Ile Ser Leu Leu Leu Asp Pro Gly Ser Phe Val 
65                  70                  75                  80  


Glu Ser Asp Met Phe Val Glu His Arg Cys Ala Asp Phe Gly Met Ala 
                85                  90                  95      


Ala Asp Lys Asn Lys Phe Pro Gly Asp Ser Val Val Thr Gly Arg Gly 
            100                 105                 110         


Arg Ile Asn Gly Arg Leu Val Tyr Val Phe Ser Gln Asp Phe Thr Val 
        115                 120                 125             


Phe Gly Gly Ser Leu Ser Gly Ala His Ala Gln Lys Ile Cys Lys Ile 
    130                 135                 140                 


Met Asp Gln Ala Ile Thr Val Gly Ala Pro Val Ile Gly Leu Asn Asp 
145                 150                 155                 160 


Ser Gly Gly Ala Arg Ile Gln Glu Gly Val Glu Ser Leu Ala Gly Tyr 
                165                 170                 175     


Ala Asp Ile Phe Leu Arg Asn Val Thr Ala Ser Gly Val Ile Pro Gln 
            180                 185                 190         


Ile Ser Leu Ile Met Gly Pro Cys Ala Gly Gly Ala Val Tyr Ser Pro 
        195                 200                 205             


Ala Leu Thr Asp Phe Thr Phe Met Val Lys Asp Thr Ser Tyr Leu Phe 
    210                 215                 220                 


Ile Thr Gly Pro Asp Val Val Lys Ser Val Thr Asn Glu Asp Val Thr 
225                 230                 235                 240 


Gln Glu Glu Leu Gly Gly Ala Lys Thr His Thr Thr Met Ser Gly Val 
                245                 250                 255     


Ala His Arg Ala Phe Glu Asn Asp Val Asp Ala Leu Cys Asn Leu Arg 
            260                 265                 270         


Asp Phe Phe Asn Tyr Leu Pro Leu Ser Ser Gln Asp Pro Ala Pro Val 
        275                 280                 285             


Arg Glu Cys His Asp Pro Ser Asp Arg Leu Val Pro Glu Leu Asp Thr 
    290                 295                 300                 


Ile Val Pro Leu Glu Ser Thr Lys Ala Tyr Asn Met Val Asp Ile Ile 
305                 310                 315                 320 


His Ser Val Val Asp Glu Arg Glu Phe Phe Glu Ile Met Pro Asn Tyr 
                325                 330                 335     


Ala Lys Asn Ile Ile Val Gly Phe Ala Arg Met Asn Gly Arg Thr Val 
            340                 345                 350         


Gly Ile Val Gly Asn Gln Pro Lys Val Ala Ser Gly Cys Leu Asp Ile 
        355                 360                 365             


Asn Ser Ser Val Lys Gly Ala Arg Phe Val Arg Phe Cys Asp Ala Phe 
    370                 375                 380                 


Asn Ile Pro Leu Ile Thr Phe Val Asp Val Pro Gly Phe Leu Pro Gly 
385                 390                 395                 400 


Thr Ala Gln Glu Tyr Gly Gly Ile Ile Arg His Gly Ala Lys Leu Leu 
                405                 410                 415     


Tyr Ala Phe Ala Glu Ala Thr Val Pro Lys Val Thr Val Ile Thr Arg 
            420                 425                 430         


Lys Ala Tyr Gly Gly Ala Tyr Asp Val Met Ser Ser Lys His Leu Cys 
        435                 440                 445             


Gly Asp Thr Asn Tyr Ala Trp Pro Thr Ala Glu Ile Ala Val Met Gly 
    450                 455                 460                 


Ala Lys Gly Ala Val Glu Ile Ile Phe Lys Gly His Glu Asn Val Glu 
465                 470                 475                 480 


Ala Ala Gln Ala Glu Tyr Ile Glu Lys Phe Ala Asn Pro Phe Pro Ala 
                485                 490                 495     


Ala Val Arg Gly Phe Val Asp Asp Ile Ile Gln Pro Ser Ser Thr Arg 
            500                 505                 510         


Ala Arg Ile Cys Cys Asp Leu Asp Val Leu Ala Ser Lys Lys Val Gln 
        515                 520                 525             


Arg Pro Trp Arg Lys His Ala Asn Ile Pro Leu 
    530                 535                 


