                         SEQUENCE LISTING

<110>  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
       INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
       BORDES, Florence
       RIGOUIN, Coraline
       MARTY, Alain
       GUEROULT, Marc
       ANDRE, Isabelle
       BARBE, Sophie
       PERCHERON, Benjamin
       CROUX, Christian
       DABOUSSI, Fayza
 
<120>  Mutant yeast strain capable of producing medium chain fatty acids

<130>  NADIncF539-184-PCT

<150>  EP17305044.4
<151>  2017-01-13

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  1850
<212>  PRT
<213>  Yarrowia lipolytica

<400>  1

Met His Pro Glu Val Glu Gln Glu Leu Ala His Val Leu Leu Thr Glu 
1               5                   10                  15      


Leu Leu Ala Tyr Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln 
            20                  25                  30          


Asp Val Leu Phe Lys Gln Phe Asn Val Glu Arg Val Val Glu Val Gly 
        35                  40                  45              


Pro Ser Pro Thr Leu Ala Gly Met Ala Gln Arg Thr Leu Lys Ser Lys 
    50                  55                  60                  


Tyr Glu Ser Tyr Asp Ala Ala Leu Ser Leu Gln Arg Glu Ile Leu Cys 
65                  70                  75                  80  


Tyr Ser Lys Asp Gln Lys Asp Ile Tyr Tyr Leu Ala Asp Glu Ala Asp 
                85                  90                  95      


Glu Ala Pro Ala Pro Ala Ala Gly Gly Asp Ala Pro Ala Ala Pro Ala 
            100                 105                 110         


Ala Ala Ala Pro Ala Ala Ala Ala Ala Pro Ala Ala Ala Ala Ala Pro 
        115                 120                 125             


Ser Gly Pro Val Ala Lys Val Glu Asp Ala Pro Val Lys Ala Gln Glu 
    130                 135                 140                 


Ile Leu His Ala Leu Val Ala His Lys Leu Lys Lys Thr Pro Glu Gln 
145                 150                 155                 160 


Val Pro Leu Ser Lys Ala Ile Lys Asp Leu Val Gly Gly Lys Ser Thr 
                165                 170                 175     


Ile Gln Asn Glu Ile Leu Gly Asp Leu Gly Lys Glu Phe Gly Ala Thr 
            180                 185                 190         


Pro Glu Lys Pro Glu Asp Thr Pro Leu Gly Glu Leu Ala Glu Ser Phe 
        195                 200                 205             


Gln Ala Ser Phe Asp Gly Lys Leu Gly Lys Gln Ser Ser Ser Leu Ile 
    210                 215                 220                 


Ala Arg Leu Met Ser Ser Lys Met Pro Gly Gly Phe Ser Leu Thr Ser 
225                 230                 235                 240 


Ala Arg Ser Tyr Leu Asp Ser Arg Trp Gly Leu Ala Ala Gly Arg Gln 
                245                 250                 255     


Asp Ser Val Leu Leu Val Ala Leu Met Asn Glu Pro Lys Asn Arg Leu 
            260                 265                 270         


Gly Ser Glu Ala Glu Ala Lys Ala Tyr Leu Asp Glu Gln Thr Gln Lys 
        275                 280                 285             


Tyr Ala Ala Ser Ala Gly Leu Asn Leu Ser Ala Pro Ala Gly Gly Ala 
    290                 295                 300                 


Glu Gly Gly Asn Gly Gly Gly Ala Val Ile Asp Ser Ala Ala Phe Asp 
305                 310                 315                 320 


Ala Leu Thr Lys Asp Gln Arg Tyr Leu Val Gln Gln Gln Leu Glu Leu 
                325                 330                 335     


Phe Ala Asn Tyr Leu Lys Gln Asp Leu Arg Gln Gly Ser Lys Val Ala 
            340                 345                 350         


Ala Ala Gln Lys Glu Ala Met Asp Ile Leu Gln Ala Glu Leu Asp Leu 
        355                 360                 365             


Trp Asn Ser Glu His Gly Glu Val Tyr Ala Glu Gly Ile Lys Pro Ala 
    370                 375                 380                 


Phe Ser Ala Leu Lys Ala Arg Val Tyr Asp Ser Tyr Trp Asn Trp Ala 
385                 390                 395                 400 


Arg Gln Asp Ser Leu Ser Met Tyr Phe Asp Ile Val Phe Gly Arg Leu 
                405                 410                 415     


Ser Thr Val Asp Arg Glu Ile Met Ala Lys Cys Ile His Leu Met Asn 
            420                 425                 430         


Arg Thr Asn His Asn Leu Ile Asp Tyr Met Gln Tyr His Met Asp His 
        435                 440                 445             


Val Pro Val His Lys Gly Ala Thr Tyr Glu Leu Ala Lys Gln Leu Gly 
    450                 455                 460                 


Leu Gln Leu Leu Glu Asn Cys Lys Glu Thr Leu Thr Glu Ala Pro Val 
465                 470                 475                 480 


Tyr Lys Asp Val Ser Tyr Pro Thr Gly Pro Gln Thr Thr Ile Asp Val 
                485                 490                 495     


Lys Gly Asn Ile Val Tyr Asn Glu Val Pro Arg Pro Asn Val Arg Lys 
            500                 505                 510         


Leu Glu Gln Tyr Val His Glu Met Ala Cys Gly Gly Glu Leu Thr Lys 
        515                 520                 525             


Asp Pro Ser Phe Val Gly Glu Gly Val Gln Gly Glu Leu Lys Lys Leu 
    530                 535                 540                 


Tyr Ser Gln Ile Ser Ala Leu Ala Lys Thr Gln Thr Gly Ser Thr Leu 
545                 550                 555                 560 


Asp Ile Glu Ala Leu Tyr Ser Asp Leu Val Ala Lys Ile Ser Gln Ala 
                565                 570                 575     


Glu Asp Ala Ser Lys Pro Val Val Glu Asn Lys Ala Val Ser Ala Ser 
            580                 585                 590         


Ile Thr Pro Gly Thr Leu Pro Phe Leu His Ile Lys Lys Lys Thr Glu 
        595                 600                 605             


Leu Gly Ala Trp Asn Tyr Asp Ser Glu Thr Thr Ala Thr Tyr Leu Asp 
    610                 615                 620                 


Gly Leu Glu Val Ala Ala Arg Asp Gly Leu Thr Phe Gln Gly Lys Thr 
625                 630                 635                 640 


Ala Leu Ile Thr Gly Ala Gly Ala Gly Ser Ile Gly Ala Ser Ile Leu 
                645                 650                 655     


Gln Gly Leu Ile Ser Gly Gly Cys Lys Val Ile Val Thr Thr Ser Arg 
            660                 665                 670         


Tyr Ser Arg Lys Val Thr Glu Tyr Tyr Gln Ser Leu Tyr Thr Lys Phe 
        675                 680                 685             


Gly Ala Lys Gly Ser Thr Leu Ile Val Val Pro Phe Asn Gln Gly Ser 
    690                 695                 700                 


Lys Lys Asp Val Asp Glu Leu Val Ser Phe Ile Tyr Asn Asp Pro Lys 
705                 710                 715                 720 


Asn Gly Gly Leu Gly Trp Asp Leu Asp Phe Val Val Pro Phe Ala Ala 
                725                 730                 735     


Leu Pro Glu Asn Gly Ile Glu Leu Glu His Ile Asp Ser Lys Ser Glu 
            740                 745                 750         


Leu Ala His Arg Ile Met Leu Thr Asn Leu Leu Arg Leu Leu Gly Asn 
        755                 760                 765             


Val Lys Lys Gln Lys Val Ala His Ser Tyr Glu Thr Arg Pro Ala Gln 
    770                 775                 780                 


Val Met Leu Pro Leu Ser Pro Asn His Gly Asn Phe Gly Ser Asp Gly 
785                 790                 795                 800 


Leu Tyr Ser Glu Ser Lys Ile Ser Leu Glu Thr Leu Phe Asn Arg Trp 
                805                 810                 815     


His Thr Glu Ser Trp Gly Ser Tyr Leu Thr Ile Val Gly Val Val Ile 
            820                 825                 830         


Gly Trp Thr Arg Gly Thr Gly Leu Met Ser Ala Asn Asn Ile Thr Ala 
        835                 840                 845             


Glu Gly Leu Glu Gln Leu Gly Val Arg Thr Phe Ser Gln Thr Glu Met 
    850                 855                 860                 


Ala Phe Ser Ile Met Gly Leu Met Thr Lys Asp Ile Val Arg Leu Ala 
865                 870                 875                 880 


Gln Asn Ser Pro Val Trp Ala Asp Leu Asn Gly Gly Phe Gln Tyr Ile 
                885                 890                 895     


Pro Asp Leu Lys Gly Val Val Gly Lys Ile Arg Arg Asp Ile Val Glu 
            900                 905                 910         


Thr Ser Glu Ile Arg Arg Ala Val Ala Gln Glu Thr Ala Ile Glu Gln 
        915                 920                 925             


Lys Val Val Asn Gly Pro His Ala Asp Leu Pro Tyr Gln Lys Val Glu 
    930                 935                 940                 


Val Lys Pro Arg Ala Asn Leu Lys Phe Asp Phe Pro Thr Leu Lys Ser 
945                 950                 955                 960 


Tyr Ala Glu Val Lys Glu Leu Ser Pro Ala Gly Asp Ala Leu Glu Gly 
                965                 970                 975     


Leu Leu Asp Leu Ser Ser Val Ile Val Val Thr Gly Phe Ala Glu Val 
            980                 985                 990         


Gly Pro Trp Gly Asn Ala Arg Thr  Arg Trp Asp Met Glu  Ala Asn Gly 
        995                 1000                 1005             


Val Phe  Ser Leu Glu Gly Ala  Ile Glu Met Ala Trp  Ile Met Gly 
    1010                 1015                 1020             


Leu Ile  Lys His His Asn Gly  Pro Leu Pro Gly Met  Pro Gln Tyr 
    1025                 1030                 1035             


Ser Gly  Trp Ile Asp Thr Lys  Thr Lys Gln Pro Val  Asp Asp Arg 
    1040                 1045                 1050             


Asp Ile  Lys Thr Lys Tyr Glu  Asp Tyr Leu Leu Glu  His Ala Gly 
    1055                 1060                 1065             


Ile Arg  Leu Ile Glu Pro Glu  Leu Phe His Gly Tyr  Asn Pro Lys 
    1070                 1075                 1080             


Lys Lys  Thr Phe Leu Gln Glu  Val Ile Val Glu His  Asp Leu Glu 
    1085                 1090                 1095             


Pro Phe  Glu Ala Ser Lys Glu  Ser Ala Glu Gln Phe  Ala Leu Glu 
    1100                 1105                 1110             


Gln Gly  Ala Asn Val Glu Ile  Phe Ala Val Pro Glu  Ser Asp Gln 
    1115                 1120                 1125             


Trp Thr  Val Arg Leu Leu Lys  Gly Ala Lys Leu Leu  Ile Pro Lys 
    1130                 1135                 1140             


Ala Leu  Lys Phe Asp Arg Leu  Val Ala Gly Gln Ile  Pro Thr Gly 
    1145                 1150                 1155             


Trp Asp  Ala Arg Arg Tyr Gly  Ile Pro Glu Asp Ile  Cys Asp Gln 
    1160                 1165                 1170             


Val Asp  Pro Ile Thr Leu Tyr  Ala Leu Val Ser Thr  Val Glu Ala 
    1175                 1180                 1185             


Leu Leu  Ala Ser Gly Ile Thr  Asp Pro Tyr Glu Phe  Tyr Lys Tyr 
    1190                 1195                 1200             


Val His  Val Ser Glu Val Gly  Asn Cys Ser Gly Ser  Gly Met Gly 
    1205                 1210                 1215             


Gly Ile  Thr Ala Leu Arg Gly  Met Phe Lys Asp Arg  Phe Met Asp 
    1220                 1225                 1230             


Lys Pro  Val Gln Asn Asp Ile  Leu Gln Glu Ser Phe  Ile Asn Thr 
    1235                 1240                 1245             


Met Ser  Ala Trp Val Asn Met  Leu Leu Leu Ser Ser  Ser Gly Pro 
    1250                 1255                 1260             


Ile Lys  Thr Pro Val Gly Ala  Cys Ala Thr Ala Val  Glu Ser Val 
    1265                 1270                 1275             


Asp Ile  Gly Cys Glu Thr Ile  Leu Ser Gly Lys Ala  Arg Ile Cys 
    1280                 1285                 1290             


Leu Val  Gly Gly Tyr Asp Asp  Phe Gln Glu Glu Ser  Ser Gln Glu 
    1295                 1300                 1305             


Phe Ala  Asn Met Asn Ala Thr  Ser Asn Ala Glu Thr  Glu Ile Thr 
    1310                 1315                 1320             


His Gly  Arg Thr Pro Ala Glu  Met Ser Arg Pro Ile  Thr Ser Thr 
    1325                 1330                 1335             


Arg Ala  Gly Phe Met Glu Ala  Gln Gly Ala Gly Thr  Gln Val Leu 
    1340                 1345                 1350             


Met Ala  Ala Asp Leu Ala Ile  Ala Met Gly Val Pro  Ile Tyr Cys 
    1355                 1360                 1365             


Ile Val  Gly Tyr Val Asn Thr  Ala Thr Asp Lys Ile  Gly Arg Ser 
    1370                 1375                 1380             


Val Pro  Ala Pro Gly Lys Gly  Ile Leu Thr Thr Ala  Arg Glu His 
    1385                 1390                 1395             


Gln Thr  Leu Lys His Ala Asn  Pro Leu Leu Asn Ile  Lys Tyr Arg 
    1400                 1405                 1410             


Lys Arg  Gln Leu Asp Ser Arg  Leu Arg Asp Ile Lys  Arg Trp Ala 
    1415                 1420                 1425             


Glu Gly  Glu Met Glu Ala Ile  Asp Ile Glu Leu Asp  Asp Val Ser 
    1430                 1435                 1440             


Asp Ala  Asp Lys Glu Ser Phe  Ile Gln Glu Arg Ser  Ala His Ile 
    1445                 1450                 1455             


Gln Ser  Gln Ser Asp Arg Met  Ile Arg Glu Ala Lys  Asn Ser Trp 
    1460                 1465                 1470             


Gly Asn  Ala Phe Phe Lys Gln  Asp Ala Arg Ile Ser  Pro Ile Arg 
    1475                 1480                 1485             


Gly Ala  Leu Ala Thr Tyr Gly  Leu Thr Ile Asp Asp  Ile Ser Val 
    1490                 1495                 1500             


Ala Ser  Phe His Gly Thr Ser  Thr Lys Ala Asn Glu  Lys Asn Glu 
    1505                 1510                 1515             


Thr Thr  Thr Val Asn Ala Met  Leu Glu His Leu Gly  Arg Thr Arg 
    1520                 1525                 1530             


Gly Asn  Pro Val Tyr Gly Ile  Phe Gln Lys Tyr Leu  Thr Gly His 
    1535                 1540                 1545             


Pro Lys  Gly Ala Ala Gly Ala  Trp Met Leu Asn Gly  Ala Ile Gln 
    1550                 1555                 1560             


Cys Leu  Asn Ser Gly Ile Ile  Pro Gly Asn Arg Asn  Ala Asp Asn 
    1565                 1570                 1575             


Val Asp  Ala Tyr Phe Glu Gln  Cys Gln His Val Val  Phe Pro Ser 
    1580                 1585                 1590             


Arg Ser  Leu Gln Thr Asp Gly  Leu Lys Ala Ala Ser  Val Thr Ser 
    1595                 1600                 1605             


Phe Gly  Phe Gly Gln Lys Gly  Ala Gln Ala Ile Val  Ile His Pro 
    1610                 1615                 1620             


Asp Tyr  Leu Tyr Ala Ala Leu  Thr Pro Ser Glu Tyr  Ser Glu Tyr 
    1625                 1630                 1635             


Thr Thr  Arg Val Ala Gln Arg  Tyr Lys Lys Ala Tyr  Arg Tyr Tyr 
    1640                 1645                 1650             


His Asn  Ala Ile Ala Glu Glu  Ser Met Phe Gln Ala  Lys Asp Lys 
    1655                 1660                 1665             


Ala Pro  Tyr Ser Ala Glu Leu  Glu Gln Glu Val Tyr  Leu Asp Pro 
    1670                 1675                 1680             


Leu Val  Arg Val His Gln Asn  Glu Asp Thr Glu Gln  Tyr Ser Phe 
    1685                 1690                 1695             


Asn Ala  Lys Asp Leu Ala Ala  Ser Ala Phe Val Lys  Asn Ser His 
    1700                 1705                 1710             


Lys Asp  Thr Ala Lys Val Leu  Ala Asn Leu Thr Ser  Gln Val Ser 
    1715                 1720                 1725             


Gly Ser  Gly Lys Asn Val Gly  Val Asp Val Glu Ala  Ile Ser Ala 
    1730                 1735                 1740             


Ile Asn  Ile Asp Asn Asp Thr  Phe Leu Asp Arg Asn  Phe Thr Ala 
    1745                 1750                 1755             


Asn Glu  Gln Ala Tyr Cys Phe  Lys Ala Pro Ser Pro  Gln Ser Ser 
    1760                 1765                 1770             


Phe Ala  Gly Thr Trp Ser Ala  Lys Glu Ala Val Phe  Lys Ser Leu 
    1775                 1780                 1785             


Gly Val  Lys Ser Gln Gly Gly  Gly Ala Glu Leu Lys  Ser Ile Glu 
    1790                 1795                 1800             


Ile Thr  Arg Asp Gly Asn Gly  Ala Pro Val Val Val  Leu His Gly 
    1805                 1810                 1815             


Ala Ala  Lys Asp Ala Ala Ala  Ser Lys Gly Ile Ser  Thr Val Lys 
    1820                 1825                 1830             


Val Ser  Ile Ser His Asp Asp  Ser Gln Ala Val Ala  Val Ala Val 
    1835                 1840                 1845             


Ala Glu  
    1850 


<210>  2
<211>  2716
<212>  PRT
<213>  Rhodotorula sp. JG-1b

<400>  2

Met Tyr Asp Gln Pro Glu Gln Asp Lys Pro Ala Leu Pro Leu Glu Phe 
1               5                   10                  15      


Lys Tyr Lys Tyr Asp Pro Ser Thr Pro Tyr Ala Pro Ile His Glu Ile 
            20                  25                  30          


Val Glu Asp Arg Asn Thr Arg Ile Lys Gln His Tyr Trp Asp Leu Trp 
        35                  40                  45              


Asn Leu Gly Gly Lys Ser Gly Glu Gln Phe Thr Gln Leu Lys Val Thr 
    50                  55                  60                  


Asp Glu Phe Val Asp Asp Gly Ala Thr Ile Ser Ala Asp Glu Val Glu 
65                  70                  75                  80  


Ala Phe Cys Arg Val Val Gly Ile Glu Gly Glu Ala Tyr Lys Lys Ser 
                85                  90                  95      


Tyr Lys His Gly Met Gln Ile Pro Leu Asp Phe Ala Ile Lys Met Gly 
            100                 105                 110         


Trp Arg Ser Ile Met Lys Pro Ile Phe Pro Pro Ala Ile Asp Gly Asp 
        115                 120                 125             


Leu Leu Lys Leu Val His Leu Ser Asn Gly Phe Arg Val Phe Asp Asp 
    130                 135                 140                 


Ala Pro Ala Leu Lys Val Gly Asp Val Val Lys Thr Val Ser Arg Ile 
145                 150                 155                 160 


Glu Ser Ile Thr Asn Ser Asp Thr Gly Lys Thr Val Thr Val Arg Gly 
                165                 170                 175     


Val Leu Tyr Leu Thr Ser Ser Ala Asp Ala Lys Gly Lys Glu Ala Ser 
            180                 185                 190         


Ser Asp Asp Gln Ile Pro Ile Ile Glu Val Thr Ser Ser Phe Phe Tyr 
        195                 200                 205             


Arg Gly Lys Phe Thr Asp Phe Ser Gln Thr Phe Ser Arg Val Thr Gln 
    210                 215                 220                 


Pro Thr Tyr Ser Val Pro Ile Asn Thr Pro Gln Ala Leu Ala Val Leu 
225                 230                 235                 240 


Gln Ala Lys Glu Trp Phe Gln Trp Asp Asp Asp Ser Lys Pro Leu Glu 
                245                 250                 255     


Val Gly Thr Thr Leu Gln Phe Lys Leu Glu Ser His Tyr Thr Phe His 
            260                 265                 270         


Asp Lys Ser Ser Tyr Thr Met Met Asn Thr Thr Gly Gly Ala Tyr Ile 
        275                 280                 285             


Ile Thr Pro Glu Leu Lys Leu Ala Val Lys Val Ala Thr Ile Asp Tyr 
    290                 295                 300                 


Thr Ser Glu Gly Glu Gly Val Val Ile Gly Asp Ala Cys Ile Glu Tyr 
305                 310                 315                 320 


Leu Lys Arg His Gly Thr Ala Leu Asn Gln Pro Asn Val Leu Glu Asn 
                325                 330                 335     


Gly Gly Tyr Thr Leu Thr Lys Ser Gly Gln Cys Thr Phe Thr Thr Pro 
            340                 345                 350         


Ala Ser Asn Leu Asp Tyr Ser Leu Thr Ser Gly Asp Thr Asn Pro Ile 
        355                 360                 365             


His Thr Asn Pro Tyr Phe Ala Ser Leu Ala Ser Leu Pro Gly Thr Ile 
    370                 375                 380                 


Thr His Gly Met His Thr Ser Ala Arg Thr Arg Lys Tyr Val Glu Gln 
385                 390                 395                 400 


Val Val Ala Asp Asn Val Gly Pro Arg Val Arg Lys Tyr Glu Val Ser 
                405                 410                 415     


Phe Thr Ala Met Cys Leu Pro Ser Arg Lys Met Glu Val Arg Leu Lys 
            420                 425                 430         


His Val Gly Met Thr Ser Asn Gly Asp Arg Leu Ile Lys Val Glu Thr 
        435                 440                 445             


Val Asp Val Glu Ala Gly Asn Val Val Leu Thr Gly Thr Ala Glu Val 
    450                 455                 460                 


Ala Gln Ala Pro Thr Ala Tyr Val Phe Thr Gly Gln Gly Ser Gln Glu 
465                 470                 475                 480 


Pro Gly Met Gly Met Glu Leu Tyr Asn Ser Ser Pro Val Ala Arg Ala 
                485                 490                 495     


Val Trp Asp Glu Ala Asp Arg His Leu Gly Glu Val Tyr Gly Phe Ser 
            500                 505                 510         


Ile Leu Glu Ile Val Arg Asn Asn Pro Lys Glu Lys Thr Val His Phe 
        515                 520                 525             


Gly Gly Leu Lys Gly Gln Ala Thr Arg Gln Lys Tyr Met Asp Met Thr 
    530                 535                 540                 


Tyr Thr Ser Ala Asp Ala Glu Gly His Val Arg Thr Leu Pro Leu Phe 
545                 550                 555                 560 


Gly Asp Ile Asp Leu Arg Thr Ser Arg Tyr Thr Phe Gln Ser Pro Thr 
                565                 570                 575     


Gly Leu Leu Tyr Ala Thr Gln Phe Ala Gln Ile Ala Leu Val Val Thr 
            580                 585                 590         


Glu Lys Ala Ala Phe Glu Asp Met Arg Ala Lys Gly Leu Phe Gln Lys 
        595                 600                 605             


Asn Cys Met Phe Ala Gly His Ser Leu Gly Glu Tyr Ser Ala Leu Ala 
    610                 615                 620                 


Ser Ile Ala Asp Ile Leu Pro Ile Ser Ala Leu Val Asp Val Val Phe 
625                 630                 635                 640 


Tyr Arg Gly Ile Thr Met Gln Arg Ala Val Glu Arg Asp His Leu Asn 
                645                 650                 655     


Arg Ser Ser Tyr Gly Met Val Ala Ala Asn Pro Ser Arg Ile Gly Lys 
            660                 665                 670         


Thr Phe Gly Asp Ala Ala Leu Arg Glu Val Val Glu Thr Ile Ser Arg 
        675                 680                 685             


Arg Gly Asn Ile Leu Ile Glu Val Val Asn Tyr Asn Val Glu Gly Gln 
    690                 695                 700                 


Gln Tyr Val Val Ala Gly His Leu Val Ala Leu Gln Ser Leu Thr Asn 
705                 710                 715                 720 


Val Leu Asn Phe Leu Lys Val Gln Lys Ile Asp Leu Val Lys Leu Thr 
                725                 730                 735     


Glu Thr Met Ser Ile Glu Gln Val Lys Glu His Leu Cys Glu Ile Val 
            740                 745                 750         


Asp Glu Cys Val Gln Lys Ala Arg Asp Leu Gln Gly Lys Thr Gly Phe 
        755                 760                 765             


Ile Thr Leu Glu Arg Gly Phe Ala Thr Ile Pro Leu Pro Gly Ile Asp 
    770                 775                 780                 


Val Pro Phe His Ser Arg Tyr Leu Trp Ala Gly Val Met Pro Phe Arg 
785                 790                 795                 800 


Thr Tyr Leu Ser Lys Lys Val Asn Pro Ala His Phe Asn Ala Asp Leu 
                805                 810                 815     


Leu Val Gly Arg Tyr Ile Pro Asn Leu Thr Ala Val Pro Tyr Glu Val 
            820                 825                 830         


Asn Lys Glu Tyr Ala Glu Arg Ile His Thr Gln Thr Ser Ser Pro Arg 
        835                 840                 845             


Leu Asn Lys Ile Leu Ser Ser Trp Asp Glu Glu Gln Trp Gly Ala Pro 
    850                 855                 860                 


Glu Asn Arg Asn Lys Leu Gly Tyr Ala Ile Leu Ile Glu Leu Leu Ala 
865                 870                 875                 880 


Tyr Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln Asp Ile Leu 
                885                 890                 895     


Phe Lys Asp Phe Lys Phe Glu Arg Leu Val Glu Leu Gly Pro Ser Pro 
            900                 905                 910         


Thr Leu Thr Gly Met Ala Ser Arg Thr Gln Lys Leu Lys Tyr Asp Ala 
        915                 920                 925             


His Asp Ser Ala Leu Gly Ile Lys Arg Ala Ile Tyr Cys Ile Ala Lys 
    930                 935                 940                 


Asn Gln Lys Glu Ile Tyr Tyr Gln Asn Asp Asp Val Thr Asp Asp Ala 
945                 950                 955                 960 


Pro Ala Pro Ala Ala Ala Ala Pro Ser Ala Pro Ala Pro Lys Ala Ala 
                965                 970                 975     


Ala Ala Pro Val Ala Ala Ala Pro Pro Pro Pro Ala Pro Val Ala Ala 
            980                 985                 990         


Ala Pro Ala Ala Ala Val Ala Asp  Glu Pro Leu Lys Ala  Ala Val Asp 
        995                 1000                 1005             


Thr Leu  Arg Ala Ile Ile Ala  Gln Lys Leu Lys Lys  Pro Ile Ala 
    1010                 1015                 1020             


Glu Val  Pro Leu Asn Lys Ser  Ile Lys Asp Leu Val  Gly Gly Lys 
    1025                 1030                 1035             


Ser Thr  Leu Gln Asn Glu Ile  Leu Gly Asp Leu Gln  Gly Glu Phe 
    1040                 1045                 1050             


Ala Ser  Ala Pro Glu Lys Gly  Glu Glu Met Pro Leu  Ser Glu Leu 
    1055                 1060                 1065             


Gly Ala  Ala Leu Asn Gln Gly  Tyr Pro Gly Ser Leu  Gly Lys Tyr 
    1070                 1075                 1080             


Thr Thr  Gly Leu Val Ala Arg  Met Met Gly Gly Lys  Met Pro Gly 
    1085                 1090                 1095             


Gly Phe  Gly Leu Ser Ala Ala  Lys Ala His Leu Ala  Lys Ala His 
    1100                 1105                 1110             


Gly Leu  Gly Pro Gly Arg Thr  Asp Gly Ala Leu Leu  Val Ala Leu 
    1115                 1120                 1125             


Thr Met  Glu Pro Glu Lys Arg  Leu Gly Ser Glu Ala  Asp Ala Lys 
    1130                 1135                 1140             


Ala Trp  Leu Asp Ser Val Ala  Ser Ala Tyr Ala Ala  Gln Ala Gly 
    1145                 1150                 1155             


Ile Ser  Leu Gly Ala Ala Gly  Gly Gly Gly Gly Gly  Gly Ala Val 
    1160                 1165                 1170             


Gly Gly  Gly Met Met Ile Asn  Thr Glu Gln Leu Asp  Lys Leu Gln 
    1175                 1180                 1185             


Glu Lys  Gln Asp Asn Phe Val  Ser Gln Gln Val Asp  Leu Phe Leu 
    1190                 1195                 1200             


Arg Tyr  Leu Gly Lys Asp Ser  Arg Glu Gly His Arg  Leu Ala Asp 
    1205                 1210                 1215             


Leu Gln  Lys Ala Glu Val Ala  Ser Leu Gln Asp Lys  Leu Asp Ala 
    1220                 1225                 1230             


Ile Ser  Arg Glu His Gly Asp  Ala Tyr Val Gln Gly  Ile Gln Pro 
    1235                 1240                 1245             


Val Phe  Asn Pro Leu Lys Ala  Arg His Phe Asn Ser  Ser Trp Asn 
    1250                 1255                 1260             


Trp Val  Arg Gln Asp Ala Leu  Met Met Trp Met Asp  Ile Leu Phe 
    1265                 1270                 1275             


Gly Arg  Leu Thr Thr Val Asp  Arg Asp Ile Thr Ala  Arg Cys Leu 
    1280                 1285                 1290             


Val Ile  Met Asn Arg Ala Asp  Pro Ala Leu Leu Asp  Tyr Met Gln 
    1295                 1300                 1305             


Tyr Val  Ile Asp Asn Thr Pro  Thr Glu Arg Gly Glu  Thr Tyr Val 
    1310                 1315                 1320             


Leu Ala  Lys Ala Phe Gly Gln  Thr Leu Leu Asp Asn  Cys Arg Glu 
    1325                 1330                 1335             


Met Val  Gly Gln Ala Pro Leu  Tyr Lys Asp Val Thr  Phe Pro Thr 
    1340                 1345                 1350             


Ala Pro  Lys Thr Thr Val Thr  Val Lys Gly Glu Ile  Leu Ser Glu 
    1355                 1360                 1365             


Glu Val  Asn Arg Pro Gly Val  Ser Arg Leu Glu Lys  Tyr Val Ala 
    1370                 1375                 1380             


Glu Met  Ala Ala Gly Ser Lys  Val Thr Val Gln Ser  Val Asn Leu 
    1385                 1390                 1395             


Asp Lys  Val Gln Asp Gln Val  Glu Lys Leu Tyr Lys  Leu Val Lys 
    1400                 1405                 1410             


Ser Gln  Pro Gln Ile Ser Lys  Thr His Met Gln Ser  Ile Lys Ser 
    1415                 1420                 1425             


Leu Tyr  Thr Glu Val Val Arg  Gly Leu Gly Lys Asp  Ala Pro Pro 
    1430                 1435                 1440             


Pro Thr  Thr His Lys Thr Gly  Thr Arg Ala Arg Arg  Pro Ser Ser 
    1445                 1450                 1455             


Gln Phe  Leu Arg Pro Ala Ala  Val Gln Glu Ala Thr  Tyr Leu Pro 
    1460                 1465                 1470             


Glu Asp  Lys Val Pro Leu Leu  His Leu Lys Arg Lys  Ile Gly Asn 
    1475                 1480                 1485             


Glu Trp  Gln Tyr Ser Ser Lys  Leu Thr Ser Leu Tyr  Leu Asp Ile 
    1490                 1495                 1500             


Leu Lys  Glu Ile Ala Thr Ser  Gly Val Thr Phe Glu  His Lys Asn 
    1505                 1510                 1515             


Ala Leu  Met Thr Gly Val Gly  Lys Gly Ser Ile Gly  Val Glu Ile 
    1520                 1525                 1530             


Val Lys  Gly Leu Leu Ala Gly  Gly Ala Arg Val Val  Val Thr Thr 
    1535                 1540                 1545             


Ser Arg  Tyr Ser Arg Ser Thr  Val Glu Tyr Tyr Gln  Ala Ile Tyr 
    1550                 1555                 1560             


Gln Glu  Val Gly Ala Lys Gly  Ser Ser Leu Thr Val  Val Pro Phe 
    1565                 1570                 1575             


Asn Gln  Gly Ser Lys Gln Asp  Val Glu Ala Leu Val  Asp Tyr Ile 
    1580                 1585                 1590             


Tyr Asn  Lys Glu Lys Gly Leu  Gly Met Asp Leu Asp  Tyr Ile Leu 
    1595                 1600                 1605             


Pro Phe  Ala Ala Leu Pro Glu  Asn Gly Arg Glu Ile  Asp Gly Ile 
    1610                 1615                 1620             


Asp Asp  Arg Ser Glu Leu Ala  His Arg Ile Met Leu  Thr Asn Val 
    1625                 1630                 1635             


Leu Arg  Leu Leu Gly Ala Val  Lys Ser Lys Lys Ala  Ala Leu Lys 
    1640                 1645                 1650             


Leu Thr  Thr Arg Pro Thr Glu  Val Val Leu Pro Leu  Ser Pro Asn 
    1655                 1660                 1665             


His Gly  Leu Phe Gly Asn Asp  Gly Leu Tyr Ser Glu  Ser Lys Ile 
    1670                 1675                 1680             


Ser Leu  Glu Thr Leu Phe Asn  Arg Trp Ser Ser Glu  Ser Trp Gly 
    1685                 1690                 1695             


Glu Tyr  Leu Cys Ile Ala Gly  Ala Ile Ile Gly Trp  Thr Arg Gly 
    1700                 1705                 1710             


Thr Gly  Leu Met Ser Ala Thr  Asn Ser Val Ala Glu  Gly Ile Glu 
    1715                 1720                 1725             


Ala His  Gly Cys Arg Thr Phe  Ser Ala Lys Glu Met  Ala Phe Asn 
    1730                 1735                 1740             


Ile Leu  Gly Leu Met His Pro  Leu Val Phe Asp Val  Ala Gln Ile 
    1745                 1750                 1755             


Glu Pro  Val Trp Ala Asp Leu  Asn Gly Gly Met Asp  Lys Leu Pro 
    1760                 1765                 1770             


Asp Leu  Ala Thr Leu Thr Thr  Asp Ile Arg Thr Lys  Leu Asn Leu 
    1775                 1780                 1785             


Thr Ala  Asn Asn Arg Arg Ala  Val Ala Lys Asp His  Ser Leu Asp 
    1790                 1795                 1800             


Tyr Lys  Val Gln His Gly Pro  Ala Met Glu Gln Ile  His Gln Gln 
    1805                 1810                 1815             


Val Lys  Val Ala Pro Arg Ala  Asn Phe Ser Leu Pro  Phe Pro Glu 
    1820                 1825                 1830             


Leu Lys  Pro Ile Asp Ala Thr  Ser Glu Leu Ala Lys  Leu Arg Gly 
    1835                 1840                 1845             


Leu Ile  Asp Leu Glu Gln Val  Val Val Leu Thr Gly  Tyr Ala Glu 
    1850                 1855                 1860             


Val Gly  Pro Phe Gly Ser Ser  Arg Thr Arg Trp Glu  Met Glu Ala 
    1865                 1870                 1875             


Asn Gly  Thr Phe Ser Ile Gln  Gly Thr Leu Glu Leu  Ala Tyr Val 
    1880                 1885                 1890             


Met Gly  Leu Ile Lys His Phe  Glu Gly Arg Leu Lys  Asp Gly Thr 
    1895                 1900                 1905             


Leu Tyr  Val Gly Trp Val Asp  Ala Lys Thr Asn Glu  Pro Leu Asp 
    1910                 1915                 1920             


Asp Lys  Asp Val Lys Ala Ala  Tyr Glu Lys His Ile  Leu Ala His 
    1925                 1930                 1935             


Thr Gly  Ile Arg Leu Ile Glu  Pro Glu Ile Phe Asn  Gly Tyr Asp 
    1940                 1945                 1950             


Pro Lys  Arg Lys Gly Phe Thr  Gln Glu Ile Glu Ile  Gln His Asp 
    1955                 1960                 1965             


Leu Glu  Pro Ile Glu Ala Ser  Glu Glu Asp Ala Ala  Arg Phe Lys 
    1970                 1975                 1980             


Arg Glu  His Gly Val Leu Val  Asp Val Tyr Thr Glu  Asp Gly Ser 
    1985                 1990                 1995             


Lys Phe  Phe Val Lys Phe Lys  Lys Gly Ala Lys Leu  Asn Ile Pro 
    2000                 2005                 2010             


Lys Ala  Val Ala Phe Asp Arg  Leu Val Ala Gly Gln  Ile Pro Thr 
    2015                 2020                 2025             


Gly Trp  Ser His Lys Ala Phe  Gly Ile Pro Asp Asp  Ile Ala Ser 
    2030                 2035                 2040             


Gln Val  Asp Arg Thr Ser Leu  Trp Ala Leu Val Ser  Val Ala Glu 
    2045                 2050                 2055             


Ala Leu  Met Met Ala Gly Ile  Thr Asp Pro Tyr Glu  Leu Tyr Lys 
    2060                 2065                 2070             


Phe Val  His Pro Ser Glu Val  Gly Ser Ser Leu Gly  Ser Gly Met 
    2075                 2080                 2085             


Gly Gly  Ile Thr Ser Ile Ser  Lys Met Phe Arg Asp  Arg Arg Glu 
    2090                 2095                 2100             


Glu Lys  Asp Val Gln Lys Asp  Ile Leu Gln Glu Thr  Phe Ile Asn 
    2105                 2110                 2115             


Thr Val  Ala Gly Trp Val Asn  Leu Leu Leu Leu Ser  Ser Ser Gly 
    2120                 2125                 2130             


Pro Ile  Lys Val Pro Val Gly  Ala Cys Ala Thr Ala  Leu Gln Ser 
    2135                 2140                 2145             


Val Glu  Ile Ala Cys Asp Thr  Ile Leu Ser Gly Lys  Ala Lys Ile 
    2150                 2155                 2160             


Met Val  Ala Gly Gly Tyr Asp  Asp Phe Ser Glu Glu  Gly Ser Tyr 
    2165                 2170                 2175             


Glu Phe  Ala Asn Met Lys Ala  Thr Ser Asn Ser Glu  Thr Glu Phe 
    2180                 2185                 2190             


Ala Ala  Gly Arg Glu Pro Asn  Glu Met Ser Arg Pro  Thr Thr Ser 
    2195                 2200                 2205             


Thr Arg  Ala Gly Phe Met Glu  Ser Met Gly Cys Gly  Ala Gln Val 
    2210                 2215                 2220             


Leu Met  Ser Ala Lys Thr Ala  Ile Glu Met Gly Ala  Thr Ile Tyr 
    2225                 2230                 2235             


Gly Val  Val Ala Tyr Thr Ala  Thr Ala Thr Asp Lys  Ala Gly Arg 
    2240                 2245                 2250             


Ser Ile  Pro Ala Pro Gly Arg  Gly Val Val Gly Thr  Ala Arg Glu 
    2255                 2260                 2265             


Leu Ser  Ser Lys Tyr Pro Ser  Pro Ile Leu Asp Val  Thr Tyr Arg 
    2270                 2275                 2280             


Arg Arg  Gln Leu Glu Phe Arg  Arg Arg Gln Ile Ser  Gln Trp Leu 
    2285                 2290                 2295             


Glu Asn  Glu Thr Glu Leu Leu  Gln Met Glu Ile Glu  Ser Arg Ser 
    2300                 2305                 2310             


Asp Ala  Asp Lys Leu Pro Glu  Asp Tyr Val Ala Glu  Arg Phe Ala 
    2315                 2320                 2325             


Ser Ile  Glu Arg Glu Ala Lys  Arg Gln Glu Ser Glu  Ala Leu Ala 
    2330                 2335                 2340             


Thr Tyr  Gly Met Leu Ala Gly  Gln Asp Pro Ser Ile  Ala Pro Leu 
    2345                 2350                 2355             


Arg Arg  Ala Leu Ala Val Trp  Gly Leu Thr Ile Asp  Asp Val Gly 
    2360                 2365                 2370             


Val Ala  Ser Phe His Gly Thr  Ser Thr Val Ala Asn  Asp Lys Asn 
    2375                 2380                 2385             


Glu Ser  Asn Ala Tyr Asn Glu  Gln Phe Arg His Leu  Gly Arg Ala 
    2390                 2395                 2400             


Lys Gly  Asn Ala Cys Pro Val  Ile Ala Gln Lys Trp  Leu Thr Gly 
    2405                 2410                 2415             


His Pro  Lys Gly Gly Ala Ala  Ala Trp Met Leu Asn  Gly Met Ala 
    2420                 2425                 2430             


Gln Val  Ile Leu Ser Gly Leu  Val Pro Gly Asn Arg  Asn Ala Asp 
    2435                 2440                 2445             


Asn Ile  Gly Glu Glu Leu Arg  Ala Phe Glu Tyr Leu  Leu Tyr Pro 
    2450                 2455                 2460             


Ser Lys  Ser Ile Gln Thr Asp  Gly Ile Lys Ala Gly  Leu Leu Thr 
    2465                 2470                 2475             


Ser Phe  Gly Phe Gly Gln Val  Gly Gly Gln Ala Leu  Ile Val His 
    2480                 2485                 2490             


Pro Ser  Tyr Leu Ile Gly Ser  Leu Glu Pro Lys Gln  Phe Glu Ala 
    2495                 2500                 2505             


Tyr Lys  Gln Lys Asn Asp Val  Arg Lys Lys Trp Ser  Tyr Arg Arg 
    2510                 2515                 2520             


Phe Asn  Asp Phe Phe Val Asn  Gly Lys Leu Val Ile  Ile Lys Glu 
    2525                 2530                 2535             


Gly Ala  Pro Phe Thr Pro Glu  Leu Glu Thr Pro Val  Leu Leu Asn 
    2540                 2545                 2550             


Pro Leu  Ala Arg Thr Val Glu  Asp Lys Lys Gly Ser  Tyr Ser Met 
    2555                 2560                 2565             


Pro Lys  Glu Leu Pro Gln Ser  Pro Tyr Pro Ser Gly  Asn Ser Asn 
    2570                 2575                 2580             


Ala Ala  Ile Ala Ala Lys Leu  Val Ser Ser Ala Thr  Ser Gly Val 
    2585                 2590                 2595             


His Gly  Val Gly Val Asp Thr  Glu Met Ile Ser Ala  Ile Pro Thr 
    2600                 2605                 2610             


Ser Asp  Ser Phe Leu Glu Arg  Asn Phe Thr Asp Ala  Glu Ile Ala 
    2615                 2620                 2625             


Tyr Val  Arg Lys Ala Ser Asp  Phe Lys Ala Ser Leu  Ala Ala Arg 
    2630                 2635                 2640             


Trp Ser  Ala Lys Glu Ala Val  Phe Lys Ala Leu Lys  Thr Val Ser 
    2645                 2650                 2655             


Lys Gly  Ala Ala Ala Ser Leu  Lys Asp Ile Glu Ile  Val Ser Thr 
    2660                 2665                 2670             


Ser Gly  Ala Pro Gln Val Ala  Leu His Gly Glu Ala  Lys Ala Val 
    2675                 2680                 2685             


Ala Asp  Ala Ala Gly Ile Lys  Ser Phe Glu Leu Ser  Met Ser His 
    2690                 2695                 2700             


Ser Glu  Asp Val Ala Cys Ala  Val Ala Ile Ala Gln  Lys 
    2705                 2710                 2715     


<210>  3
<211>  2928
<212>  PRT
<213>  Rhodotorula toruloides

<400>  3

Met Val Ala Ala Gln Asp Leu Pro Leu Ala Leu Ser Ile Ser Phe Ala 
1               5                   10                  15      


Pro Glu Ser Ser Thr Ile Ser Met Thr Leu Phe Asn Gln Pro Glu Ala 
            20                  25                  30          


Ser Lys Pro Ala Leu Pro Leu Glu Leu Lys Tyr Lys Tyr Asp Pro Ser 
        35                  40                  45              


Thr Pro Tyr Ala Pro Ile His Glu Ile Thr Glu Asp Arg Asn Gln Arg 
    50                  55                  60                  


Ile Lys Gln His Tyr Trp Asp Leu Trp Gly Leu Gly Asn Lys Ala Asp 
65                  70                  75                  80  


Gln Gly Ile Ser Gln Leu Lys Ile Thr Asp Glu Phe Gln Gly Asp Leu 
                85                  90                  95      


Val Thr Ile Ser Ala Asp Glu Ile Glu Ala Phe Cys Arg Val Val Gly 
            100                 105                 110         


Ile Glu Gly Glu Ala Tyr Lys Arg Asn His Lys Ala Gly Met Gln Val 
        115                 120                 125             


Pro Leu Asp Phe Ala Ile Lys Leu Gly Trp Lys Ala Ile Met Lys Pro 
    130                 135                 140                 


Ile Phe Pro Ser Thr Ile Asp Gly Asp Leu Leu Lys Leu Val His Leu 
145                 150                 155                 160 


Ser Asn Gly Phe Arg Val Leu Pro Asp Thr Pro Thr Leu Gln Val Gly 
                165                 170                 175     


Asp Val Val Thr Thr Thr Ser Arg Ile Glu Ser Ile Thr Asn Ser Asp 
            180                 185                 190         


Thr Gly Lys Thr Val Ser Val Arg Gly Val Ile Ser Leu Val Ser Ser 
        195                 200                 205             


Ala Asp Ser Lys Gly Lys Asp Ala Ser Thr Glu Asp Arg Ile Pro Leu 
    210                 215                 220                 


Ile Glu Val Thr Ser Ser Phe Phe Tyr Arg Gly Lys Phe Ser Asp Tyr 
225                 230                 235                 240 


Ala Gln Thr Phe Ser Arg Val Ala His Pro Thr Tyr Ser Val Pro Ile 
                245                 250                 255     


Thr Thr Pro Glu Ala Val Ala Val Leu Gln Ser Lys Glu Trp Phe Gln 
            260                 265                 270         


Trp Asp Asp Asp Ser Lys Pro Leu Glu Val Gly Thr Lys Leu Gln Phe 
        275                 280                 285             


Lys Val Glu Ser Asn Tyr Val Tyr Ala Asp Lys Ser Ser Tyr Ala Met 
    290                 295                 300                 


Ala Thr Val Thr Gly Gly Ala Tyr Val Ile Thr Pro Glu Leu Lys Leu 
305                 310                 315                 320 


Ala Val Lys Val Ala Thr Val Asp Tyr Thr Ser Glu Gly Glu Gly Val 
                325                 330                 335     


Ile Gln Gly Asp Pro Val Ile Glu Tyr Leu Lys Arg His Gly Ser Ala 
            340                 345                 350         


Leu Asp Gln Pro Ile Met Leu Glu Asn Gly Gly Tyr Ser Leu Thr Lys 
        355                 360                 365             


Ala Gly Gln Cys Thr Phe Thr Thr Pro Ala Ser Asn Leu Asp Tyr Ser 
    370                 375                 380                 


Leu Thr Ser Gly Asp Thr Asn Pro Ile His Thr Asn Pro Tyr Phe Ala 
385                 390                 395                 400 


Ser Leu Ala Tyr Leu Pro Gly Thr Ile Thr His Gly Met His Ser Ser 
                405                 410                 415     


Ala Arg Thr Arg Lys Phe Val Glu Gln Val Ala Ala Asp Asn Val Gly 
            420                 425                 430         


Ala Arg Val Arg Lys Tyr Glu Val Gly Phe Thr Ala Met Cys Leu Pro 
        435                 440                 445             


Ser Arg Lys Met Glu Val Arg Leu Lys His Val Gly Met Thr Ala Asp 
    450                 455                 460                 


Gly Asn Arg Leu Ile Lys Val Glu Thr Val Asp Val Glu Gly Gly Asn 
465                 470                 475                 480 


Val Val Leu Ser Gly Thr Ala Glu Val Ala Gln Ala Pro Thr Ala Tyr 
                485                 490                 495     


Val Phe Thr Gly Gln Gly Ser Gln Glu Pro Gly Met Gly Met Glu Leu 
            500                 505                 510         


Tyr Ala Asn Ser Pro Val Ala Arg Ala Val Trp Asp Glu Ala Asp Arg 
        515                 520                 525             


His Leu Gly Glu Val Tyr Gly Phe Ser Ile Leu Glu Ile Val Arg Thr 
    530                 535                 540                 


Asn Pro Lys Glu Lys Thr Val His Phe Gly Gly Leu Lys Gly Gln Ala 
545                 550                 555                 560 


Thr Arg Gln Lys Tyr Met Asp Met Ser Tyr Thr Thr Thr Asp His Glu 
                565                 570                 575     


Gly Asn Val Lys Thr Leu Pro Leu Phe Gly Asp Ile Asp Leu Arg Thr 
            580                 585                 590         


Ser Arg Tyr Thr Phe Ser Ser Pro Thr Gly Leu Leu Tyr Ala Thr Gln 
        595                 600                 605             


Phe Ala Gln Ile Ala Leu Val Val Thr Glu Lys Ala Ala Phe Glu Asp 
    610                 615                 620                 


Met Arg Ala Lys Gly Leu Val Gln Lys Asp Cys Val Phe Ala Gly His 
625                 630                 635                 640 


Ser Leu Gly Glu Tyr Ser Ala Leu Ala Ser Ile Ala Asp Ile Leu Pro 
                645                 650                 655     


Ile Ser Ala Leu Val Asp Val Val Phe Tyr Arg Gly Ile Thr Met Gln 
            660                 665                 670         


Arg Ala Val Glu Arg Asp His Leu Asn Arg Ser Ser Tyr Gly Met Val 
        675                 680                 685             


Ala Val Asn Pro Ser Arg Ile Gly Lys Ser Phe Gly Asp Ala Ala Leu 
    690                 695                 700                 


Arg Glu Val Val Asp Thr Ile Ala Arg Arg Gly Asn Ile Leu Ile Glu 
705                 710                 715                 720 


Val Val Asn Tyr Asn Val Glu Gly Gln Gln Tyr Val Val Ala Gly His 
                725                 730                 735     


Leu Val Ala Leu Gln Ser Leu Thr Asn Val Leu Asn Phe Leu Lys Ile 
            740                 745                 750         


Gln Lys Ile Asp Leu Ala Lys Leu Thr Glu Thr Met Ser Ile Glu Gln 
        755                 760                 765             


Val Lys Glu His Leu Cys Glu Ile Val Asp Glu Cys Val Gln Lys Ala 
    770                 775                 780                 


Arg Asp Leu Gln Ala Lys Thr Gly Phe Ile Thr Leu Glu Arg Gly Phe 
785                 790                 795                 800 


Ala Thr Ile Pro Leu Pro Gly Ile Asp Val Pro Phe His Ser Arg Tyr 
                805                 810                 815     


Leu Trp Ala Gly Val Met Pro Phe Arg Thr Tyr Leu Ser Lys Lys Val 
            820                 825                 830         


Asn Pro Ala His Phe Asn Ala Asp Leu Leu Val Gly Arg Tyr Ile Pro 
        835                 840                 845             


Asn Leu Thr Ala Val His Tyr Glu Val Ser Lys Glu Tyr Ala Glu Arg 
    850                 855                 860                 


Ile His Thr Gln Thr Ser Ser Pro Arg Leu Asn Lys Ile Leu Lys Ala 
865                 870                 875                 880 


Trp Asp Glu Glu Arg Trp Gly Ala Pro Glu Asn Arg Asn Lys Leu Gly 
                885                 890                 895     


Tyr Ala Ile Leu Ile Glu Leu Leu Ala Tyr Gln Phe Ala Ser Pro Val 
            900                 905                 910         


Arg Trp Ile Glu Thr Gln Asp Ile Leu Phe Arg Asp Phe Lys Phe Glu 
        915                 920                 925             


Arg Leu Val Glu Leu Gly Pro Ser Pro Thr Leu Thr Gly Met Ala Thr 
    930                 935                 940                 


Arg Thr Gln Lys Leu Lys Tyr Asp Ala His Asp Ser Ser Val Gly Ile 
945                 950                 955                 960 


Lys Arg Ser Ile Tyr Cys Ile Ala Lys His Gln Lys Glu Ile Tyr Tyr 
                965                 970                 975     


Gln Phe Asp Asp Val Ala Gly Glu Glu Ala Pro Ala Pro Ala Ala Val 
            980                 985                 990         


Ala Pro Ser Ala Pro Ala Pro Lys  Ala Ala Pro Val Ala  Ala Ala Pro 
        995                 1000                 1005             


Pro Pro  Pro Ala Pro Val Ala  Ala Ala Pro Ala Ala  Ala Val Ala 
    1010                 1015                 1020             


Asp Glu  Pro Leu Lys Ala Val  Asp Thr Leu Arg Ile  Ile Ile Ala 
    1025                 1030                 1035             


Gln Lys  Leu Lys Lys Pro Val  Gly Glu Val Pro Leu  Thr Lys Ser 
    1040                 1045                 1050             


Ile Lys  Glu Leu Val Gly Gly  Lys Ser Thr Leu Gln  Asn Glu Ile 
    1055                 1060                 1065             


Leu Gly  Asp Leu Gln Gly Glu  Phe Ser Ser Ala Pro  Glu Lys Gly 
    1070                 1075                 1080             


Glu Glu  Met Pro Leu Gln Glu  Leu Gly Ala Ala Leu  Gln Gln Gly 
    1085                 1090                 1095             


Tyr Ser  Gly Lys Leu Gly Lys  Tyr Thr Thr Gly Val  Ile Ser Arg 
    1100                 1105                 1110             


Met Ile  Gly Ala Lys Met Pro  Gly Gly Phe Gly Leu  Ser Ala Val 
    1115                 1120                 1125             


Gln Gly  His Leu Gly Lys Thr  Tyr Gly Leu Gly Ala  Gly Arg Ile 
    1130                 1135                 1140             


Asp Gly  Val Leu Leu Phe Ala  Val Thr Gln Glu Pro  Ala Lys Arg 
    1145                 1150                 1155             


Leu Ala  Asn Glu Gly Glu Ala  Lys Ala Trp Val Asp  Ser Val Ala 
    1160                 1165                 1170             


Gln Gly  Tyr Ala Ser Met Ala  Gly Ile Ser Leu Ala  Ala Gly Gly 
    1175                 1180                 1185             


Gly Ala  Ala Ala Ala Ala Pro  Ala Met Ala Phe Ala  Ala Pro Ala 
    1190                 1195                 1200             


Ala Ala  Gly Gly Gly Ala Pro  Ala Ala Val Pro Asp  Glu Pro Leu 
    1205                 1210                 1215             


Lys Ala  Thr Asp Thr Leu Arg  Ala Ile Ile Ala Gln  Lys Leu Lys 
    1220                 1225                 1230             


Lys Gln  Ile Pro Asp Val Pro  Leu Thr Lys Ser Ile  Lys Asp Leu 
    1235                 1240                 1245             


Val Gly  Gly Lys Ser Thr Leu  Gln Asn Glu Ile Leu  Gly Asp Leu 
    1250                 1255                 1260             


Gln Gly  Glu Phe Ser Ser Ala  Pro Glu Lys Gly Glu  Glu Met Pro 
    1265                 1270                 1275             


Leu Gln  Glu Leu Gly Ala Ala  Leu Asn Gln Gly Tyr  Ser Gly Thr 
    1280                 1285                 1290             


Leu Gly  Lys His Thr Ser Gly  Leu Val Ala Arg Met  Met Gly Ala 
    1295                 1300                 1305             


Lys Met  Pro Gly Gly Phe Gly  Leu Ser Ala Ala Lys  Ala His Leu 
    1310                 1315                 1320             


Ser Lys  Ala His Gly Leu Gly  Pro Gly Arg Thr Asp  Gly Ala Leu 
    1325                 1330                 1335             


Leu Val  Ala Leu Thr Lys Glu  Pro Glu Lys Arg Leu  Gly Ser Glu 
    1340                 1345                 1350             


Ala Asp  Ala Lys Ala Trp Leu  Asp Gly Val Ala Gln  Ala Tyr Ala 
    1355                 1360                 1365             


Ser Gln  Ala Gly Ile Thr Leu  Gly Ala Gly Gly Gly  Gly Gly Gly 
    1370                 1375                 1380             


Ala Ala  Val Gly Gly Ala Gly  Phe Met Ile Asn Thr  Glu Gln Leu 
    1385                 1390                 1395             


Asp Lys  Met Gln Glu Lys Gln  Asp Asn Phe Val Ser  Gln Gln Val 
    1400                 1405                 1410             


Glu Leu  Phe Leu Arg Tyr Leu  Gly Lys Asp Ser Arg  Glu Gly His 
    1415                 1420                 1425             


Arg Leu  Ala Asp Met Gln Lys  Ala Glu Val Ala Asn  Leu Gln Glu 
    1430                 1435                 1440             


Lys Leu  Asp Ser Ile Ala Arg  Glu His Gly Asp Ala  Tyr Val Gln 
    1445                 1450                 1455             


Gly Ile  Gln Pro Val Phe Asp  Pro Leu Lys Ala Arg  His Phe Asn 
    1460                 1465                 1470             


Ser Ser  Trp Asn Trp Val Arg  Gln Asp Ala Leu Met  Met Trp Met 
    1475                 1480                 1485             


Asp Ile  Leu Phe Gly Arg Leu  Thr Thr Val Asp Arg  Asp Ile Thr 
    1490                 1495                 1500             


Ala Arg  Cys Leu Val Ile Met  Asn Arg Ala Asp Pro  Ser Leu Ile 
    1505                 1510                 1515             


Asp Tyr  Met Gln Tyr Thr Ile  Asp Asn Thr Pro Val  Glu Arg Gly 
    1520                 1525                 1530             


Glu His  Tyr Val Leu Ala Lys  Gln Phe Gly Gln Gln  Leu Leu Asp 
    1535                 1540                 1545             


Asn Cys  Arg Glu Met Ile Gly  Gln Ala Pro Leu Tyr  Lys Asp Val 
    1550                 1555                 1560             


Thr Phe  Pro Thr Ala Pro Lys  Thr Thr Val Asn Ala  Lys Gly Asp 
    1565                 1570                 1575             


Ile Ile  Thr Glu Glu Val Asn  Arg Pro Gly Val Ser  Arg Leu Glu 
    1580                 1585                 1590             


Lys Tyr  Val Ala Glu Met Ala  Ala Gly Ser Lys Val  Thr Val Ala 
    1595                 1600                 1605             


Ser Val  Asn Leu Asp Lys Val  Gln Glu Gln Val Glu  Lys Leu Tyr 
    1610                 1615                 1620             


Lys Leu  Val Lys Ser Gln Pro  Gln Ile Ser Lys Gln  His Met Thr 
    1625                 1630                 1635             


Ser Ile  Lys Ser Leu Tyr Ala  Glu Val Val Arg Gly  Leu Gly Lys 
    1640                 1645                 1650             


Asp Ala  Gly Pro Pro Pro Val  His Lys Ala Gly Thr  Arg Ala Arg 
    1655                 1660                 1665             


Arg Pro  Ser Ser Gln Phe Leu  Arg Pro Ala Ala Val  Ser Glu Ala 
    1670                 1675                 1680             


Thr Phe  Leu Pro Glu Asp Lys  Val Pro Leu Leu His  Leu Lys Arg 
    1685                 1690                 1695             


Lys Ile  Gly Asn Asp Trp Gln  Tyr Ser Ser Lys Leu  Thr Ser Leu 
    1700                 1705                 1710             


Tyr Leu  Asp Ile Leu Lys Glu  Ile Ala Thr Ser Gly  Val Thr Phe 
    1715                 1720                 1725             


Glu His  Lys Asn Ala Leu Met  Thr Gly Val Gly Lys  Gly Ser Ile 
    1730                 1735                 1740             


Gly Ile  Glu Ile Val Lys Gly  Leu Leu Ala Gly Gly  Ala Arg Val 
    1745                 1750                 1755             


Val Ile  Thr Thr Ser Arg Tyr  Ser Arg Ser Thr Val  Glu Tyr Tyr 
    1760                 1765                 1770             


Gln Ala  Ile Tyr Gln Glu Val  Gly Ser Lys Gly Ser  Ser Leu Thr 
    1775                 1780                 1785             


Val Val  Pro Phe Asn Gln Gly  Ser Lys Gln Asp Val  Glu Ala Leu 
    1790                 1795                 1800             


Val Asp  Phe Ile Tyr Ser Lys  Asp Lys Gly Leu Gly  Met Asp Leu 
    1805                 1810                 1815             


Asp Tyr  Ile Leu Pro Phe Ala  Ala Leu Pro Glu Asn  Gly Arg Glu 
    1820                 1825                 1830             


Ile Asp  Gly Ile Asp Asp Arg  Ser Glu Leu Ala His  Arg Ile Met 
    1835                 1840                 1845             


Leu Thr  Asn Leu Leu Arg Leu  Leu Gly Ala Val Lys  Ser Lys Lys 
    1850                 1855                 1860             


Ala Ala  Leu Lys Leu Thr Thr  Arg Pro Thr Glu Val  Val Leu Pro 
    1865                 1870                 1875             


Leu Ser  Pro Asn His Gly Leu  Phe Gly Asn Asp Gly  Leu Tyr Ser 
    1880                 1885                 1890             


Glu Ser  Lys Ile Ser Leu Glu  Thr Leu Phe Asn Arg  Trp Ser Ser 
    1895                 1900                 1905             


Glu Ser  Trp Gly Glu Tyr Leu  Cys Leu Ala Gly Ala  Val Ile Gly 
    1910                 1915                 1920             


Trp Thr  Arg Gly Thr Gly Leu  Met Ser Ala Thr Asn  Ser Val Ala 
    1925                 1930                 1935             


Glu Gly  Ile Glu Ala Gln Gly  Cys Arg Thr Phe Ser  Ala Lys Glu 
    1940                 1945                 1950             


Met Ala  Phe Asn Ile Leu Gly  Leu Met His Pro Leu  Val Phe Asp 
    1955                 1960                 1965             


Val Ala  Gln Ile Glu Pro Val  Trp Ala Asp Leu Asn  Gly Gly Met 
    1970                 1975                 1980             


Asp Lys  Leu Pro Asp Leu Ala  Asn Leu Thr Thr Glu  Ile Arg Lys 
    1985                 1990                 1995             


Lys Leu  Asn Leu Thr Ala Ser  Thr Arg Arg Ala Ile  Ala Lys Asp 
    2000                 2005                 2010             


Asn Ser  Phe Asp Tyr Lys Val  Ala His Gly Pro Ala  Met Glu Gln 
    2015                 2020                 2025             


Ile His  Gln Arg Ile Asn Val  Ala Pro Arg Ala Asn  Phe Ser Leu 
    2030                 2035                 2040             


Pro Phe  Pro Glu Leu Lys Pro  Ile Asp Ala Lys Ser  Glu Leu Ala 
    2045                 2050                 2055             


Lys Leu  Arg Gly Leu Ile Asp  Leu Glu Lys Val Val  Val Met Thr 
    2060                 2065                 2070             


Gly Tyr  Ala Glu Val Gly Pro  Phe Gly Ser Ser Arg  Thr Arg Trp 
    2075                 2080                 2085             


Glu Met  Glu Ala Asn Gly Thr  Phe Ser Ile Gln Gly  Thr Leu Glu 
    2090                 2095                 2100             


Leu Ala  Tyr Val Met Gly Leu  Ile Lys His Phe Glu  Gly Arg Leu 
    2105                 2110                 2115             


Lys Asp  Gly Thr Leu Tyr Val  Gly Trp Val Asp Ala  Lys Thr Asn 
    2120                 2125                 2130             


Glu Pro  Leu Asp Asp Lys Asp  Val Lys Ala Ala Tyr  Glu Lys His 
    2135                 2140                 2145             


Ile Leu  Ala His Thr Gly Ile  Arg Leu Ile Glu Pro  Glu Ile Phe 
    2150                 2155                 2160             


Asn Gly  Tyr Asp Pro Lys Arg  Lys Gly Phe Thr Gln  Glu Ile Glu 
    2165                 2170                 2175             


Ile Gln  His Asp Leu Glu Pro  Ile Glu Ala Ser Glu  Glu Asp Ala 
    2180                 2185                 2190             


Ala Arg  Phe Lys Arg Glu His  Gly Ala Leu Val Asp  Val Tyr Thr 
    2195                 2200                 2205             


Glu Asp  Gly Ser Lys Phe Phe  Val Lys Phe Lys Lys  Gly Ala Lys 
    2210                 2215                 2220             


Leu His  Ile Pro Lys Ala Val  Ala Phe Asp Arg Leu  Val Ala Gly 
    2225                 2230                 2235             


Gln Ile  Pro Thr Gly Trp Ser  His Lys Ala Phe Gly  Ile Pro Asp 
    2240                 2245                 2250             


Asp Ile  Ala Ser Gln Val Asp  Arg Thr Ser Leu Trp  Ala Leu Val 
    2255                 2260                 2265             


Ser Val  Ala Glu Ala Leu Met  Met Ala Gly Ile Thr  Asp Pro Tyr 
    2270                 2275                 2280             


Glu Leu  Tyr Lys Trp Ile His  Pro Ser Glu Val Gly  Ser Ser Leu 
    2285                 2290                 2295             


Gly Ser  Gly Met Gly Gly Ile  Thr Ser Ile Ser Lys  Met Phe Arg 
    2300                 2305                 2310             


Asp Arg  Arg Glu Glu Lys Asp  Val Gln Lys Asp Ile  Leu Gln Glu 
    2315                 2320                 2325             


Thr Phe  Ile Asn Thr Val Ala  Gly Trp Val Asn Leu  Leu Leu Leu 
    2330                 2335                 2340             


Ser Ser  Ser Gly Pro Ile Lys  Ile Pro Val Gly Ala  Cys Ala Thr 
    2345                 2350                 2355             


Ala Leu  Gln Ser Val Glu Ile  Ala Cys Asp Thr Ile  Leu Ser Gly 
    2360                 2365                 2370             


Lys Ala  Lys Ile Met Val Ser  Gly Gly Tyr Asp Asp  Phe Ser Glu 
    2375                 2380                 2385             


Glu Gly  Ser Tyr Glu Phe Ala  Asn Met Lys Ala Thr  Ser Asn Ser 
    2390                 2395                 2400             


Glu Thr  Glu Phe Ala Ala Gly  Arg Glu Pro Asn Glu  Met Ser Arg 
    2405                 2410                 2415             


Pro Thr  Thr Ser Thr Arg Ala  Gly Phe Met Glu Ser  Met Gly Cys 
    2420                 2425                 2430             


Gly Ala  Gln Val Leu Met Ser  Ala Lys Thr Ala Ile  Glu Met Gly 
    2435                 2440                 2445             


Ala Thr  Ile Tyr Gly Ile Val  Ala Tyr Thr Ala Thr  Ala Thr Asp 
    2450                 2455                 2460             


Lys Ala  Gly Arg Ser Ile Pro  Ala Pro Gly Arg Gly  Val Met Gly 
    2465                 2470                 2475             


Thr Ala  Arg Glu Ile Thr Ser  Lys Tyr Pro Ser Pro  Ile Leu Asp 
    2480                 2485                 2490             


Val Thr  Tyr Arg Arg Arg Gln  Leu Glu Phe Arg Arg  Lys Gln Ile 
    2495                 2500                 2505             


Ser Gln  Trp Leu Glu Asn Glu  Thr Glu Leu Leu Lys  Phe Glu Val 
    2510                 2515                 2520             


Ser Ser  His Gly Gln Ala Thr  Lys Leu Pro Asp Asp  Tyr Val Ser 
    2525                 2530                 2535             


Glu Arg  Leu Ala Ser Ile Glu  Arg Glu Ala Lys Arg  Gln Glu Ala 
    2540                 2545                 2550             


Glu Ala  Leu Ala Thr Tyr Gly  Met Leu Ala Gly Gln  Asp Pro Thr 
    2555                 2560                 2565             


Ile Ala  Pro Leu Arg Arg Ala  Leu Ala Val Trp Gly  Leu Thr Ile 
    2570                 2575                 2580             


Asp Asp  Val Gly Val Ala Ser  Phe His Gly Thr Ser  Thr Val Ala 
    2585                 2590                 2595             


Asn Asp  Lys Asn Glu Ser Asn  Ala Tyr Asn Glu Gln  Phe Arg His 
    2600                 2605                 2610             


Leu Gly  Arg Ala Lys Gly Asn  Ala Cys Pro Val Ile  Ala Gln Lys 
    2615                 2620                 2625             


Trp Leu  Thr Gly His Pro Lys  Gly Gly Ala Ala Ala  Trp Met Leu 
    2630                 2635                 2640             


Asn Gly  Leu Ala Gln Val Ile  Gln Ser Gly Leu Val  Pro Gly Asn 
    2645                 2650                 2655             


Arg Asn  Ala Asp Asn Ile Gly  Glu Glu Leu Arg Ala  Phe Glu Tyr 
    2660                 2665                 2670             


Leu Leu  Tyr Pro Ser Lys Ser  Ile Gln Thr Asp Gly  Ile Lys Ala 
    2675                 2680                 2685             


Gly Leu  Leu Thr Ser Phe Gly  Phe Gly Gln Val Gly  Gly Gln Ala 
    2690                 2695                 2700             


Leu Ile  Val His Pro Ser Leu  Leu Ile Gly Ala Leu  Glu Pro Ala 
    2705                 2710                 2715             


Gln Phe  Glu Ala Tyr Lys Lys  Leu Asn Asp Gln Arg  Lys Lys Trp 
    2720                 2725                 2730             


Ser Tyr  Arg Arg Phe Asn Asp  Phe Phe Thr Asn Gly  Lys Leu Val 
    2735                 2740                 2745             


Ile Ile  Lys Asp Gly Thr Pro  Phe Thr Pro Glu Gln  Glu Asn Thr 
    2750                 2755                 2760             


Thr Leu  Leu Asn Pro Leu Val  Arg Ala Val Pro Asp  Lys Thr Gly 
    2765                 2770                 2775             


Ser Tyr  Ser Met Pro Lys Glu  Phe Pro Ala Thr Val  Pro Arg Ser 
    2780                 2785                 2790             


Asn Asn  Ala Glu Val Ala Asn  Lys Leu Val Ser Ala  Ala Val Gly 
    2795                 2800                 2805             


Gly Ala  Phe Gly Val Gly Thr  Asp Val Glu Leu Ile  Ser Ala Val 
    2810                 2815                 2820             


Pro Thr  Ser Glu Ser Phe Leu  Glu Arg Asn Phe Thr  Gln Asp Glu 
    2825                 2830                 2835             


Ile Ala  Tyr Cys Lys Ala Ala  Pro Asp Phe Arg Ala  Ser Leu Ala 
    2840                 2845                 2850             


Ala Arg  Trp Ser Ala Lys Glu  Ala Thr Phe Lys Ala  Leu Lys Thr 
    2855                 2860                 2865             


Glu Ser  Lys Gly Ala Ala Ala  Ser Met Gln Asp Ile  Glu Val Val 
    2870                 2875                 2880             


Ser Thr  Ser Gln Gly Pro Thr  Ile Lys Leu His Gly  Glu Val Glu 
    2885                 2890                 2895             


Lys Ile  Ala Gln Ala Ala Gly  Ile Thr Ala Phe Glu  Val Ser Leu 
    2900                 2905                 2910             


Ser His  Ser Glu Asp Val Ala  Cys Ala Val Val Ile  Ala Gln Lys 
    2915                 2920                 2925             


<210>  4
<211>  1884
<212>  PRT
<213>  Candida albicans

<400>  4

Met Lys Pro Glu Ile Glu Gln Glu Leu Ser His Thr Leu Leu Thr Glu 
1               5                   10                  15      


Leu Leu Ala Tyr Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln 
            20                  25                  30          


Asp Val Phe Leu Lys Gln His Asn Thr Glu Arg Ile Ile Glu Ile Gly 
        35                  40                  45              


Pro Ser Pro Thr Leu Ala Gly Met Ala Asn Arg Thr Ile Lys Ala Lys 
    50                  55                  60                  


Tyr Glu Ser Tyr Asp Ala Ala Leu Ser Leu Gln Arg Gln Val Leu Cys 
65                  70                  75                  80  


Tyr Ser Lys Asp Ala Lys Glu Ile Tyr Tyr Lys Pro Asp Pro Ala Asp 
                85                  90                  95      


Leu Ala Pro Lys Glu Thr Pro Lys Gln Glu Glu Ser Thr Pro Ser Ala 
            100                 105                 110         


Pro Ala Ala Ala Thr Pro Thr Pro Ala Ala Ala Ala Ala Pro Thr Pro 
        115                 120                 125             


Ala Pro Ala Pro Ala Ser Ala Gly Pro Val Glu Ser Ile Pro Asp Glu 
    130                 135                 140                 


Pro Val Lys Ala Asn Leu Leu Ile His Val Leu Val Ala Gln Lys Leu 
145                 150                 155                 160 


Lys Lys Pro Leu Asp Ala Val Pro Met Thr Lys Ala Ile Lys Asp Leu 
                165                 170                 175     


Val Asn Gly Lys Ser Thr Val Gln Asn Glu Ile Leu Gly Asp Leu Gly 
            180                 185                 190         


Lys Glu Phe Gly Ser Thr Pro Glu Lys Pro Glu Asp Thr Pro Leu Glu 
        195                 200                 205             


Glu Leu Ala Glu Gln Phe Gln Asp Ser Phe Ser Gly Gln Leu Gly Lys 
    210                 215                 220                 


Thr Ser Thr Ser Leu Ile Gly Arg Leu Met Ser Ser Lys Met Pro Gly 
225                 230                 235                 240 


Gly Phe Ser Ile Thr Thr Ala Arg Lys Tyr Leu Glu Ser Arg Phe Gly 
                245                 250                 255     


Leu Gly Ala Gly Arg Gln Asp Ser Val Leu Leu Met Ala Leu Thr Asn 
            260                 265                 270         


Glu Pro Ala Asn Arg Leu Gly Ser Glu Ala Asp Ala Lys Ala Phe Phe 
        275                 280                 285             


Asp Gly Ile Ala Gln Lys Tyr Ala Ser Ser Ala Gly Ile Ser Leu Ser 
    290                 295                 300                 


Ser Gly Ala Ala Ser Gly Ala Gly Ala Ala Asn Ser Gly Gly Ala Val 
305                 310                 315                 320 


Val Asp Ser Ala Ala Leu Asp Ala Leu Thr Ala Glu Asn Lys Lys Leu 
                325                 330                 335     


Ala Lys Gln Gln Leu Glu Val Leu Ala Arg Tyr Leu Gln Val Asp Leu 
            340                 345                 350         


Asn Lys Gly Ala Lys Ser Phe Ile Lys Glu Lys Glu Ala Ser Ala Val 
        355                 360                 365             


Leu Gln Lys Glu Leu Asp Leu Trp Glu Ala Glu His Gly Glu Phe Tyr 
    370                 375                 380                 


Ala Lys Gly Ile Gln Pro Thr Phe Ser Ala Leu Lys Ser Arg Thr Tyr 
385                 390                 395                 400 


Asp Ser Tyr Trp Asn Trp Ala Arg Gln Asp Val Leu Ser Met Tyr Phe 
                405                 410                 415     


Asp Ile Ile Phe Gly Lys Leu Thr Ser Val Asp Arg Glu Thr Ile Asn 
            420                 425                 430         


Gln Cys Ile Gln Ile Met Asn Arg Ala Asn Pro Thr Leu Ile Lys Phe 
        435                 440                 445             


Met Gln Tyr His Ile Asp His Cys Pro Glu Tyr Lys Gly Glu Thr Tyr 
    450                 455                 460                 


Lys Leu Ala Lys Arg Leu Gly Gln Gln Leu Ile Asp Asn Cys Lys Gln 
465                 470                 475                 480 


Val Leu Thr Glu Asp Pro Val Tyr Lys Asp Val Ser Arg Ile Thr Gly 
                485                 490                 495     


Pro Lys Thr Lys Val Ser Ala Lys Gly Asn Ile Glu Tyr Glu Glu Thr 
            500                 505                 510         


Gln Lys Asp Ser Val Arg Lys Phe Glu Gln Tyr Val Tyr Glu Met Ala 
        515                 520                 525             


Gln Gly Gly Ala Met Thr Lys Val Ser Gln Pro Thr Ile Gln Glu Asp 
    530                 535                 540                 


Leu Ala Arg Val Tyr Lys Ala Ile Ser Lys Gln Ala Ser Lys Asp Ser 
545                 550                 555                 560 


Lys Leu Glu Leu Gln Arg Val Tyr Glu Asp Leu Leu Lys Val Val Glu 
                565                 570                 575     


Ser Ser Lys Glu Ile Glu Thr Glu Gln Leu Thr Lys Asp Ile Leu Gln 
            580                 585                 590         


Ala Ala Thr Val Pro Thr Thr Pro Thr Glu Glu Val Asp Asp Pro Cys 
        595                 600                 605             


Thr Pro Ser Ser Asp Asp Glu Ile Ala Ser Leu Pro Asp Lys Thr Ser 
    610                 615                 620                 


Ile Ile Gln Pro Val Ser Ser Thr Ile Pro Ser Gln Thr Ile Pro Phe 
625                 630                 635                 640 


Leu His Ile Gln Lys Lys Thr Lys Asp Gly Trp Glu Tyr Asn Lys Lys 
                645                 650                 655     


Leu Ser Ser Leu Tyr Leu Asp Gly Leu Glu Ser Ala Ala Ile Asn Gly 
            660                 665                 670         


Leu Thr Phe Lys Asp Lys Tyr Val Leu Val Thr Gly Ala Gly Ala Gly 
        675                 680                 685             


Ser Ile Gly Ala Glu Ile Leu Gln Gly Leu Ile Ser Gly Gly Ala Lys 
    690                 695                 700                 


Val Ile Val Thr Thr Ser Arg Phe Ser Lys Lys Val Thr Glu Tyr Tyr 
705                 710                 715                 720 


Gln Asn Met Tyr Ala Arg Tyr Gly Ala Ala Gly Ser Thr Leu Ile Val 
                725                 730                 735     


Val Pro Phe Asn Gln Gly Ser Lys Gln Asp Val Asp Ala Leu Val Gln 
            740                 745                 750         


Tyr Ile Tyr Asp Glu Pro Lys Lys Gly Gly Leu Gly Trp Asp Leu Asp 
        755                 760                 765             


Ala Ile Ile Pro Phe Ala Ala Ile Pro Glu Asn Gly Asn Gly Leu Asp 
    770                 775                 780                 


Asn Ile Asp Ser Lys Ser Glu Phe Ala His Arg Ile Met Leu Thr Asn 
785                 790                 795                 800 


Leu Leu Arg Leu Leu Gly Ala Val Lys Ser Lys Lys Thr Thr Asp Thr 
                805                 810                 815     


Arg Pro Ala Gln Cys Ile Leu Pro Leu Ser Pro Asn His Gly Thr Phe 
            820                 825                 830         


Gly Phe Asp Gly Leu Tyr Ser Glu Ser Lys Ile Ser Leu Glu Thr Leu 
        835                 840                 845             


Phe Asn Arg Trp Tyr Ser Glu Asp Trp Gly Ser Lys Leu Thr Val Cys 
    850                 855                 860                 


Gly Ala Val Ile Gly Trp Thr Arg Gly Thr Gly Leu Met Ser Ala Asn 
865                 870                 875                 880 


Asn Ile Ile Ala Glu Gly Ile Glu Lys Leu Gly Val Arg Thr Phe Ser 
                885                 890                 895     


Gln Lys Glu Met Ala Phe Asn Ile Leu Gly Leu Leu Thr Pro Glu Ile 
            900                 905                 910         


Val Gln Leu Cys Gln Glu Glu Pro Val Met Ala Asp Leu Asn Gly Gly 
        915                 920                 925             


Leu Gln Phe Ile Asp Asn Leu Lys Asp Phe Thr Ser Lys Leu Arg Thr 
    930                 935                 940                 


Asp Leu Leu Glu Thr Ala Asp Ile Arg Arg Ala Val Ser Ile Glu Ser 
945                 950                 955                 960 


Ala Ile Glu Gln Lys Val Val Asn Gly Asp Asn Val Asp Ala Asn Tyr 
                965                 970                 975     


Ser Lys Val Met Val Glu Pro Arg Ala Asn Met Lys Phe Asp Phe Pro 
            980                 985                 990         


Thr Leu Lys Ser Tyr Asp Glu Ile  Lys Gln Ile Ala Pro  Glu Leu Glu 
        995                 1000                 1005             


Gly Met  Leu Asp Leu Glu Asn  Val Val Val Val Thr  Gly Phe Ala 
    1010                 1015                 1020             


Glu Val  Gly Pro Trp Gly Asn  Ser Arg Thr Arg Trp  Glu Met Glu 
    1025                 1030                 1035             


Ala Tyr  Gly Glu Phe Ser Leu  Glu Gly Ala Ile Glu  Met Ala Trp 
    1040                 1045                 1050             


Ile Met  Gly Phe Ile Lys Tyr  His Asn Gly Asn Leu  Lys Gly Lys 
    1055                 1060                 1065             


Pro Tyr  Ser Gly Trp Val Asp  Ala Lys Thr Gln Thr  Pro Ile Asp 
    1070                 1075                 1080             


Glu Lys  Asp Ile Lys Ser Lys  Tyr Glu Glu Glu Ile  Leu Glu His 
    1085                 1090                 1095             


Ser Gly  Ile Arg Leu Ile Glu  Pro Glu Leu Phe Asn  Gly Tyr Asp 
    1100                 1105                 1110             


Pro Lys  Lys Lys Gln Met Ile  Gln Glu Val Val Val  Gln His Asp 
    1115                 1120                 1125             


Leu Glu  Pro Phe Glu Cys Ser  Lys Glu Thr Ala Glu  Gln Tyr Lys 
    1130                 1135                 1140             


His Glu  His Gly Glu Lys Cys  Glu Ile Phe Glu Ile  Glu Glu Ser 
    1145                 1150                 1155             


Gly Glu  Tyr Thr Val Arg Ile  Leu Lys Gly Ala Thr  Leu Tyr Val 
    1160                 1165                 1170             


Pro Lys  Ala Leu Arg Phe Asp  Arg Leu Val Ala Gly  Gln Ile Pro 
    1175                 1180                 1185             


Thr Gly  Trp Asp Ala Arg Thr  Tyr Gly Ile Pro Glu  Asp Thr Ile 
    1190                 1195                 1200             


Ser Gln  Val Asp Pro Ile Thr  Leu Tyr Val Leu Val  Ala Thr Val 
    1205                 1210                 1215             


Glu Ala  Leu Leu Ser Ala Gly  Ile Thr Asp Pro Tyr  Glu Phe Tyr 
    1220                 1225                 1230             


Lys Tyr  Val His Val Ser Glu  Val Gly Asn Cys Ser  Gly Ser Gly 
    1235                 1240                 1245             


Met Gly  Gly Val Ser Ala Leu  Arg Gly Met Phe Lys  Asp Arg Tyr 
    1250                 1255                 1260             


Ala Asp  Lys Pro Val Gln Asn  Asp Ile Leu Gln Glu  Ser Phe Ile 
    1265                 1270                 1275             


Asn Thr  Met Ser Ala Trp Val  Asn Met Leu Leu Leu  Ser Ser Ser 
    1280                 1285                 1290             


Gly Pro  Ile Lys Thr Pro Val  Gly Ala Cys Ala Thr  Ala Val Glu 
    1295                 1300                 1305             


Ser Val  Asp Ile Gly Ile Glu  Thr Ile Leu Ser Gly  Lys Ala Lys 
    1310                 1315                 1320             


Val Val  Leu Val Gly Gly Tyr  Asp Asp Phe Gln Glu  Glu Gly Ser 
    1325                 1330                 1335             


Tyr Glu  Phe Ala Asn Met Asn  Ala Thr Ser Asn Ser  Ile Glu Glu 
    1340                 1345                 1350             


Phe Lys  His Gly Arg Thr Pro  Lys Glu Met Ser Arg  Pro Thr Thr 
    1355                 1360                 1365             


Thr Thr  Arg Asn Gly Phe Met  Glu Ala Gln Gly Ser  Gly Ile Gln 
    1370                 1375                 1380             


Val Ile  Met Thr Ala Asp Leu  Ala Leu Lys Met Gly  Val Pro Ile 
    1385                 1390                 1395             


His Ala  Val Leu Ala Met Thr  Ala Thr Ala Thr Asp  Lys Ile Gly 
    1400                 1405                 1410             


Arg Ser  Val Pro Ala Pro Gly  Lys Gly Ile Leu Thr  Thr Ala Arg 
    1415                 1420                 1425             


Glu His  His Gly Asn Leu Lys  Tyr Pro Ser Pro Leu  Leu Asn Ile 
    1430                 1435                 1440             


Glu Tyr  Arg Lys Arg Gln Leu  Asn Lys Arg Leu Glu  Gln Ile Lys 
    1445                 1450                 1455             


Ser Trp  Glu Glu Thr Glu Leu  Ser Tyr Leu Gln Glu  Glu Ala Glu 
    1460                 1465                 1470             


Leu Ala  Lys Glu Glu Phe Gly  Asp Glu Phe Ser Met  His Glu Phe 
    1475                 1480                 1485             


Leu Lys  Glu Arg Thr Glu Glu  Val Tyr Arg Glu Ser  Lys Arg Gln 
    1490                 1495                 1500             


Val Ser  Asp Ala Lys Lys Gln  Trp Gly Asn Ser Phe  Tyr Lys Ser 
    1505                 1510                 1515             


Asp Pro  Arg Ile Ala Pro Leu  Arg Gly Ala Leu Ala  Ala Phe Asn 
    1520                 1525                 1530             


Leu Thr  Ile Asp Asp Ile Gly  Val Ala Ser Phe His  Gly Thr Ser 
    1535                 1540                 1545             


Thr Val  Ala Asn Asp Lys Asn  Glu Ser Ala Thr Ile  Asn Asn Met 
    1550                 1555                 1560             


Met Lys  His Leu Gly Arg Ser  Glu Gly Asn Pro Val  Phe Gly Val 
    1565                 1570                 1575             


Phe Gln  Lys Tyr Leu Thr Gly  His Pro Lys Gly Ala  Ala Gly Ala 
    1580                 1585                 1590             


Trp Met  Leu Asn Gly Ala Ile  Gln Ile Leu Glu Ser  Gly Leu Val 
    1595                 1600                 1605             


Pro Gly  Asn Arg Asn Ala Asp  Asn Val Asp Lys Leu  Leu Glu Gln 
    1610                 1615                 1620             


Tyr Glu  Tyr Val Leu Tyr Pro  Ser Arg Ser Ile Gln  Thr Asp Gly 
    1625                 1630                 1635             


Ile Lys  Ala Val Ser Val Thr  Ser Phe Gly Phe Gly  Gln Lys Gly 
    1640                 1645                 1650             


Ala Gln  Ala Val Val Val His  Pro Asp Tyr Leu Phe  Ala Val Leu 
    1655                 1660                 1665             


Asp Arg  Ser Thr Tyr Glu Glu  Tyr Ala Thr Lys Val  Ser Ala Arg 
    1670                 1675                 1680             


Asn Lys  Lys Thr Tyr Arg Tyr  Met His Asn Ala Ile  Thr Arg Asn 
    1685                 1690                 1695             


Thr Met  Phe Val Ala Lys Asp  Lys Ala Pro Tyr Ser  Asp Glu Leu 
    1700                 1705                 1710             


Glu Gln  Pro Val Tyr Leu Asp  Pro Leu Ala Arg Val  Glu Glu Asn 
    1715                 1720                 1725             


Lys Lys  Lys Leu Val Phe Ser  Asp Lys Thr Ile Gln  Ser Ser Gln 
    1730                 1735                 1740             


Ser Tyr  Val Gly Glu Val Ala  Gln Lys Thr Ala Lys  Ala Leu Ser 
    1745                 1750                 1755             


Ser Leu  Asn Lys Ser Ser Lys  Gly Val Gly Val Asp  Val Glu Leu 
    1760                 1765                 1770             


Leu Ser  Ala Ile Asn Ile Asp  Asn Glu Thr Phe Ile  Glu Arg Asn 
    1775                 1780                 1785             


Phe Thr  Gly Asn Glu Val Glu  Tyr Cys Leu Asn Thr  Ala His Pro 
    1790                 1795                 1800             


Gln Ala  Ser Phe Thr Gly Thr  Trp Ser Ala Lys Glu  Ala Val Phe 
    1805                 1810                 1815             


Lys Ala  Leu Gly Val Glu Ser  Lys Gly Ala Gly Ala  Ser Leu Ile 
    1820                 1825                 1830             


Asp Ile  Glu Ile Thr Arg Asp  Val Asn Gly Ala Pro  Lys Val Ile 
    1835                 1840                 1845             


Leu His  Gly Glu Ala Lys Lys  Ala Ala Ala Lys Ala  Gly Val Lys 
    1850                 1855                 1860             


Asn Val  Asn Ile Ser Ile Ser  His Asp Asp Phe Gln  Ala Thr Ala 
    1865                 1870                 1875             


Val Ala  Leu Ser Glu Phe 
    1880                 


<210>  5
<211>  1883
<212>  PRT
<213>  Candida tropicalis

<400>  5

Met Lys Pro Glu Ile Glu Gln Glu Leu Ser His Thr Leu Leu Thr Glu 
1               5                   10                  15      


Leu Leu Ala Tyr Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln 
            20                  25                  30          


Asp Val Phe Leu Lys Gln His Asn Thr Glu Arg Ile Ile Glu Ile Gly 
        35                  40                  45              


Pro Ser Pro Thr Leu Ala Gly Met Ala Asn Arg Thr Ile Lys Ala Lys 
    50                  55                  60                  


Tyr Glu Ser Tyr Asp Ala Ala Leu Ser Leu Gln Arg Glu Val Leu Cys 
65                  70                  75                  80  


Tyr Ser Lys Asp Ala Lys Glu Ile Tyr Tyr Lys Pro Asp Pro Ala Asp 
                85                  90                  95      


Leu Ala Pro Lys Glu Glu Pro Lys Lys Glu Glu Ala Ala Ala Thr Pro 
            100                 105                 110         


Ala Ala Ala Ala Pro Ala Ala Ala Ala Ala Ala Pro Val Ala Ala Ala 
        115                 120                 125             


Pro Ala Pro Ala Ala Ala Ala Gly Pro Val Glu Ser Ile Pro Asp Glu 
    130                 135                 140                 


Pro Val Lys Ala Ser Leu Leu Ile His Val Leu Val Ala Gln Lys Leu 
145                 150                 155                 160 


Lys Lys Pro Leu Asp Ala Val Pro Met Ser Lys Ala Ile Lys Asp Leu 
                165                 170                 175     


Val Asn Gly Lys Ser Thr Val Gln Asn Glu Ile Leu Gly Asp Leu Gly 
            180                 185                 190         


Lys Glu Phe Gly Ser Thr Pro Glu Lys Pro Glu Asp Thr Pro Leu Glu 
        195                 200                 205             


Glu Leu Ala Glu Gln Phe Gln Asp Ser Phe Ser Gly Gln Leu Gly Lys 
    210                 215                 220                 


Thr Ser Thr Ser Leu Ile Gly Arg Leu Met Ser Ser Lys Met Pro Gly 
225                 230                 235                 240 


Gly Phe Ser Ile Thr Thr Ala Arg Lys Tyr Leu Glu Ser Arg Phe Gly 
                245                 250                 255     


Leu Gly Ser Gly Arg Gln Asp Ser Val Leu Leu Val Ala Leu Thr Asn 
            260                 265                 270         


Glu Pro Ala Ala Arg Leu Gly Ser Glu Ala Glu Ala Lys Thr Phe Leu 
        275                 280                 285             


Asp Thr Met Ala Gln Lys Tyr Ala Ser Ser Ala Gly Ile Ser Leu Thr 
    290                 295                 300                 


Ser Ala Ser Ala Gly Ala Gly Ala Gly Gly Ala Ala Gly Gly Ala Val 
305                 310                 315                 320 


Val Asp Ser Ala Ala Leu Asp Ala Leu Thr Ala Glu Asn Lys Lys Leu 
                325                 330                 335     


Ala Arg Gln Gln Leu Glu Val Leu Ala Arg Tyr Leu Gln Val Asp Leu 
            340                 345                 350         


Asn Gln Gly Ala Lys Ser Tyr Ile Lys Glu Lys Glu Ala Ser Ala Val 
        355                 360                 365             


Leu Gln Lys Glu Leu Asp Leu Trp Glu Ala Glu His Gly Glu Phe Tyr 
    370                 375                 380                 


Ala Lys Gly Ile Lys Pro Thr Phe Ser Ser Leu Lys Ala Arg Thr Tyr 
385                 390                 395                 400 


Asp Ser Tyr Trp Asn Trp Ala Arg Gln Asp Val Leu Ser Met Tyr Phe 
                405                 410                 415     


Asp Ile Ile Phe Gly Lys Leu Thr Ser Val Asp Arg Glu Thr Ile Asn 
            420                 425                 430         


Gln Cys Ile Gln Ile Met Asn Arg Ser Asn Pro Thr Leu Ile Lys Phe 
        435                 440                 445             


Met Gln Tyr His Ile Asp His Cys Pro Glu Tyr Lys Gly Glu Thr Tyr 
    450                 455                 460                 


Lys Leu Ala Lys Arg Leu Gly Gln Gln Leu Ile Asp Asn Cys Lys Gln 
465                 470                 475                 480 


Thr Leu Thr Glu Asp Pro Val Tyr Lys Asp Val Ser Arg Ile Thr Gly 
                485                 490                 495     


Pro Lys Thr Thr Val Ser Ala Lys Gly Asn Ile Glu Tyr Glu Glu Ala 
            500                 505                 510         


Glu Lys Asp Ser Val Arg Lys Phe Glu Gln Tyr Val Tyr Glu Met Ala 
        515                 520                 525             


Gln Gly Gly Glu Met Thr Lys Ile Ala Gln Pro Thr Ile Gln Glu Asp 
    530                 535                 540                 


Leu Ala Arg Val Tyr Lys Ala Ile Ser Lys Gln Ala Ser Arg Glu Ser 
545                 550                 555                 560 


Lys Leu Glu Leu Gln Lys Val Tyr Glu Gln Leu Leu Lys Val Val Ala 
                565                 570                 575     


Gly Ser Thr Glu Ile Glu Thr Gln Gln Leu Thr Lys Asp Ile Leu Gln 
            580                 585                 590         


Ala Pro Thr Gly Ala Asn Thr Pro Thr Asp Glu Asp Glu Ile Ser Thr 
        595                 600                 605             


Ala Asp Ser Asp Asp Glu Ile Ala Ser Leu Pro Asp Lys Thr Ala Ile 
    610                 615                 620                 


Ser Gln Pro Val Ser Ser Thr Val Pro His Gln Thr Ile Pro Phe Leu 
625                 630                 635                 640 


His Ile Gln Lys Lys Thr Asn Asp Gly Trp Glu Tyr Asp Arg Lys Leu 
                645                 650                 655     


Ser Ala Leu Tyr Leu Asp Gly Leu Glu Ser Ala Ala Val Asn Gly Leu 
            660                 665                 670         


Thr Phe Lys Asp Lys Tyr Val Leu Val Thr Gly Ala Gly Ala Gly Ser 
        675                 680                 685             


Ile Gly Ala Glu Ile Leu Gln Gly Leu Ile Ser Gly Gly Ala Lys Val 
    690                 695                 700                 


Val Val Thr Thr Ser Arg Phe Ser Lys Lys Val Thr Glu Tyr Tyr Gln 
705                 710                 715                 720 


Asn Met Tyr Ala Arg Tyr Gly Ala Ala Gly Ser Thr Leu Ile Val Val 
                725                 730                 735     


Pro Phe Asn Gln Gly Ser Lys Gln Asp Val Asp Ala Leu Val Glu Tyr 
            740                 745                 750         


Ile Tyr Asn Asp Pro Lys Lys Gly Gly Leu Gly Trp Asp Leu Asp Ala 
        755                 760                 765             


Ile Ile Pro Phe Ala Ala Ile Pro Glu Asn Gly Asn Gly Ile Asp Asn 
    770                 775                 780                 


Ile Asp Ser Arg Ser Glu Phe Ala His Arg Ile Met Leu Thr Asn Leu 
785                 790                 795                 800 


Leu Arg Leu Leu Gly Ala Val Lys Ser Lys Lys Thr Thr Asp Thr Arg 
                805                 810                 815     


Pro Ala Gln Cys Ile Leu Pro Met Ser Pro Asn His Gly Thr Phe Gly 
            820                 825                 830         


Phe Asp Gly Leu Tyr Ser Glu Ser Lys Ile Ser Leu Glu Thr Leu Phe 
        835                 840                 845             


Asn Arg Trp Tyr Ser Glu Asp Trp Gly Ser Lys Leu Thr Val Cys Gly 
    850                 855                 860                 


Ala Val Ile Gly Trp Thr Arg Gly Thr Gly Leu Met Ser Ala Asn Asn 
865                 870                 875                 880 


Ile Ile Ala Glu Gly Ile Glu Lys Met Gly Val Arg Thr Phe Ser Gln 
                885                 890                 895     


Lys Glu Met Ala Phe Asn Ile Leu Gly Leu Met Thr Pro Asp Ile Val 
            900                 905                 910         


Lys Leu Cys Gln Glu Glu Pro Val Met Ala Asp Leu Asn Gly Gly Leu 
        915                 920                 925             


Gln Phe Ile Glu Asn Leu Lys Asp Phe Thr Ser Lys Leu Arg Ser Asp 
    930                 935                 940                 


Leu Met Glu Ser Ala Glu Val Arg Arg Ala Val Ser Ile Glu Ser Ala 
945                 950                 955                 960 


Ile Glu Gln Lys Val Val Asn Gly Asp Asn Val Asp Ala Asn Tyr Ser 
                965                 970                 975     


Lys Val Thr Val Gln Pro Arg Ala Asn Met Lys Phe Asp Phe Pro Thr 
            980                 985                 990         


Leu Lys Ser Tyr Asp Asp Ile Lys  Lys Ile Ala Pro Glu  Leu Glu Gly 
        995                 1000                 1005             


Met Leu  Asp Leu Glu Ser Val  Ile Val Val Thr Gly  Phe Ala Glu 
    1010                 1015                 1020             


Val Gly  Pro Trp Gly Asn Ala  Arg Thr Arg Trp Glu  Met Glu Ala 
    1025                 1030                 1035             


His Gly  Glu Phe Ser Leu Glu  Gly Ala Ile Glu Met  Ala Trp Ile 
    1040                 1045                 1050             


Met Gly  Phe Ile Lys Tyr His  Asn Gly Asn Leu Lys  Gly Lys Pro 
    1055                 1060                 1065             


Tyr Ser  Gly Trp Val Asp Ala  Lys Thr Gln Thr Pro  Ile Asp Asp 
    1070                 1075                 1080             


Lys Asp  Ile Lys Ala Lys Tyr  Glu Glu Glu Ile Leu  Glu His Ser 
    1085                 1090                 1095             


Gly Ile  Arg Leu Ile Glu Pro  Glu Leu Phe His Gly  Tyr Asp Pro 
    1100                 1105                 1110             


Lys Lys  Lys Gln Met Ile Gln  Glu Ile Val Val Gln  His Asp Leu 
    1115                 1120                 1125             


Glu Pro  Phe Glu Ala Ser Lys  Glu Thr Ala Glu Gln  Tyr Lys His 
    1130                 1135                 1140             


Glu His  Gly Asp Lys Cys Glu  Ile Phe Glu Ile Glu  Glu Ser Gly 
    1145                 1150                 1155             


Glu Tyr  Thr Val Arg Ile Leu  Lys Gly Ala Thr Leu  Phe Val Pro 
    1160                 1165                 1170             


Lys Ala  Leu Arg Phe Asp Arg  Leu Val Ala Gly Gln  Ile Pro Thr 
    1175                 1180                 1185             


Gly Trp  Asp Ala Arg Thr Tyr  Gly Ile Pro Glu Asp  Thr Ile Ser 
    1190                 1195                 1200             


Gln Val  Asp Pro Ile Thr Leu  Tyr Val Leu Val Ala  Thr Val Glu 
    1205                 1210                 1215             


Ala Leu  Leu Ser Ala Gly Ile  Thr Asp Pro Tyr Glu  Phe Tyr Lys 
    1220                 1225                 1230             


Tyr Val  His Val Ser Glu Val  Gly Asn Cys Ser Gly  Ser Gly Met 
    1235                 1240                 1245             


Gly Gly  Val Ser Ala Leu Arg  Gly Met Phe Lys Asp  Arg Tyr Ala 
    1250                 1255                 1260             


Asp Arg  Pro Val Gln Asn Asp  Ile Leu Gln Glu Ser  Phe Ile Asn 
    1265                 1270                 1275             


Thr Met  Ser Ala Trp Val Asn  Met Leu Leu Leu Ser  Ser Ser Gly 
    1280                 1285                 1290             


Pro Ile  Lys Thr Pro Val Gly  Ala Cys Ala Thr Ala  Val Glu Ser 
    1295                 1300                 1305             


Val Asp  Ile Gly Val Glu Thr  Ile Leu Ser Gly Lys  Ala Lys Val 
    1310                 1315                 1320             


Val Met  Val Gly Gly Tyr Asp  Asp Phe Gln Glu Glu  Gly Ser Tyr 
    1325                 1330                 1335             


Glu Phe  Ala Asn Met Asn Ala  Thr Ser Asn Ser Leu  Asp Glu Phe 
    1340                 1345                 1350             


Ala His  Gly Arg Thr Pro Lys  Glu Met Ser Arg Pro  Thr Thr Thr 
    1355                 1360                 1365             


Thr Arg  His Gly Phe Met Glu  Ala Gln Gly Ser Gly  Ile Gln Val 
    1370                 1375                 1380             


Ile Met  Thr Ala Asp Leu Ala  Ile Lys Met Gly Val  Pro Ile His 
    1385                 1390                 1395             


Ala Val  Leu Ala Met Ser Ala  Thr Ala Thr Asp Lys  Ile Gly Arg 
    1400                 1405                 1410             


Ser Val  Pro Ala Pro Gly Lys  Gly Ile Leu Thr Thr  Ala Arg Glu 
    1415                 1420                 1425             


His His  Gly Asn Leu Lys Tyr  Pro Ser Pro Ile Leu  Asn Ile Lys 
    1430                 1435                 1440             


Tyr Arg  Lys Arg Gln Leu Asn  Ala Arg Leu Glu Gln  Ile Lys Ala 
    1445                 1450                 1455             


Trp Glu  Glu Ser Glu Ile Ala  Tyr Leu Gln Glu Glu  Ala Glu Leu 
    1460                 1465                 1470             


Ala Lys  Glu Glu Met Gly Asn  Glu Phe Ser Met His  Glu Phe Leu 
    1475                 1480                 1485             


Lys Glu  Arg Thr Glu Glu Val  Tyr Arg Glu Ser Lys  Arg Gln Val 
    1490                 1495                 1500             


Ser Asp  Ala Lys Lys Gln Trp  Gly Asn Gln Phe Phe  Lys Ser Asp 
    1505                 1510                 1515             


Pro Arg  Ile Ala Pro Leu Arg  Gly Ser Leu Ala Ala  Phe Asn Leu 
    1520                 1525                 1530             


Thr Ile  Asp Asp Leu Asp Val  Ala Ser Phe His Gly  Thr Ser Thr 
    1535                 1540                 1545             


Val Ala  Asn Asp Lys Asn Glu  Ser Ala Thr Ile Asn  Ser Met Met 
    1550                 1555                 1560             


Lys His  Leu Gly Arg Ser Glu  Gly Asn Pro Val Phe  Gly Val Phe 
    1565                 1570                 1575             


Gln Lys  Tyr Leu Thr Gly His  Pro Lys Gly Ala Ala  Gly Ala Trp 
    1580                 1585                 1590             


Met Leu  Asn Gly Ala Ile Gln  Ile Leu Glu Ser Gly  Ile Val Pro 
    1595                 1600                 1605             


Gly Asn  Arg Asn Ala Asp Asn  Val Asp Lys Val Leu  Glu Glu Tyr 
    1610                 1615                 1620             


Glu Tyr  Val Leu Tyr Pro Ser  Arg Ser Ile Gln Thr  Asp Gly Ile 
    1625                 1630                 1635             


Lys Ala  Val Ser Val Thr Ser  Phe Gly Phe Gly Gln  Lys Gly Ala 
    1640                 1645                 1650             


Gln Ala  Val Val Val His Pro  Asp Tyr Leu Tyr Ala  Val Leu Asp 
    1655                 1660                 1665             


Arg Ser  Thr Tyr Glu Asp Tyr  Ala Val Arg Val Ser  Ala Arg Asn 
    1670                 1675                 1680             


Lys Lys  Thr Tyr Arg Tyr Met  His Asn Ala Ile Thr  Arg Asn Thr 
    1685                 1690                 1695             


Met Phe  Val Ala Lys Asp Lys  Ala Pro Tyr Ala Asp  Glu Leu Glu 
    1700                 1705                 1710             


Gln Pro  Val Tyr Leu Asp Pro  Leu Ala Arg Val Glu  Asn Ala Lys 
    1715                 1720                 1725             


Glu Lys  Leu Val Phe Ser Asn  Lys Gly Ile Gln Ser  Asn Gln Ala 
    1730                 1735                 1740             


Tyr Thr  Gly Glu Asn Ala Arg  Asn Thr Ala Lys Ala  Leu Ala Ser 
    1745                 1750                 1755             


Leu Asn  Lys Ser Ser Lys Gly  Val Gly Val Asp Val  Glu Leu Leu 
    1760                 1765                 1770             


Ser Ala  Ile Asn Leu Glu Asn  Glu Thr Phe Ile Glu  Arg Asn Phe 
    1775                 1780                 1785             


Thr Ala  Gly Glu Val Glu Tyr  Cys Thr Lys Thr Ser  Ser Pro Gln 
    1790                 1795                 1800             


Ala Ser  Phe Thr Gly Thr Trp  Ser Ala Lys Glu Ala  Val Phe Lys 
    1805                 1810                 1815             


Ala Leu  Gly Val Glu Ser Lys  Gly Ala Gly Ala Ser  Leu Ile Asp 
    1820                 1825                 1830             


Ile Glu  Ile Thr Arg Asp Val  Asn Gly Ala Pro Gln  Val Ser Leu 
    1835                 1840                 1845             


His Gly  Asp Ala Ala Lys Ala  Ala Ala Lys Ala Gly  Val Lys Asn 
    1850                 1855                 1860             


Val Lys  Ile Ser Ile Ser His  Asp Asp Phe Gln Ala  Thr Ala Val 
    1865                 1870                 1875             


Ala Leu  Ser Glu Phe 
    1880             


<210>  6
<211>  1440
<212>  PRT
<213>  Trichosporon oleaginosus

<400>  6

Met Ser Thr Ala Thr Arg Asp Gln Glu Ala Gln Val Arg Arg Glu Leu 
1               5                   10                  15      


Thr Ser Arg Cys Ile Ala Ile Met Asn Arg Ala Asp Gln Asn Leu Leu 
            20                  25                  30          


Asp Tyr Met Lys Tyr His Ile Asp Ser Val Asp Pro Ser Lys Gly Pro 
        35                  40                  45              


Asn Tyr Glu Lys Val Lys Lys Phe Gly Gln Ile Leu Ile Asp Asn Cys 
    50                  55                  60                  


Lys Glu Val Val Asp Leu Pro Pro Val Tyr Arg Asp Val Ala Leu Pro 
65                  70                  75                  80  


Thr Ala Pro His Thr Glu Val Ser Ala Lys Gly Asp Ile Gln Tyr Ser 
                85                  90                  95      


Glu Ile Pro Arg Thr Lys Val Arg Lys Leu Glu Ser Tyr Val Lys Glu 
            100                 105                 110         


Met Ala Asn Gly Gly Glu Ile Glu Ser Gln Val Asn Leu Glu Lys Val 
        115                 120                 125             


Gln Ala Asp Ile Glu Lys Leu Trp Asp Leu Val Asn Ala Gln Pro Ser 
    130                 135                 140                 


Ile Thr Pro Ala Gln Lys Ala Ala Ile Lys Ser Met Tyr Gly Glu Val 
145                 150                 155                 160 


Val Lys Ser Leu Gly Gln Gln Ala Glu Ala Asp Asp Pro Val Thr Arg 
                165                 170                 175     


Ala Arg Asn Ala Ala Asp Lys Pro Arg Arg Asp Ser Ser Gln Phe Leu 
            180                 185                 190         


Arg Pro Asn Val Gln Asp Arg Thr Glu Val Asp Glu Glu His Leu Pro 
        195                 200                 205             


Phe Leu His Leu Lys Arg Lys Thr Gly Thr Ser Trp Ala Tyr Ser Lys 
    210                 215                 220                 


Lys Leu Thr Asn Ile Tyr Leu Asp Val Leu Thr Glu Ile Ala Thr Ser 
225                 230                 235                 240 


Gly Val Thr Phe Gln Lys Lys Ala Ala Leu Leu Thr Gly Val Gly Arg 
                245                 250                 255     


Gly Ser Ile Gly Val Glu Ile Leu Gln Gly Leu Leu Ala Gly Gly Ala 
            260                 265                 270         


Thr Cys Val Val Thr Thr Ser Arg Tyr Ser Arg Ala Val Val Asp Tyr 
        275                 280                 285             


Tyr Lys Gly Ile Phe His Glu Val Gly Ser Lys Gly Ser Lys Leu Ile 
    290                 295                 300                 


Val Val Pro Phe Asn Gly Ala Ser Arg Gln Asp Thr Glu Ala Leu Val 
305                 310                 315                 320 


Asp Tyr Ile Tyr Asn Thr Leu Asn Ile Asp Leu Asp Tyr Ile Val Pro 
                325                 330                 335     


Phe Ala Ala Leu Pro Glu Asn Gly Arg Glu Ile Asp Asn Ile Asp Asp 
            340                 345                 350         


Lys Ser Glu Leu Ala His Arg Leu Met Leu Thr Asn Leu Leu Arg Leu 
        355                 360                 365             


Leu Gly Ala Val Lys Thr Lys Lys Ala Ala Lys Lys Phe Val Thr Arg 
    370                 375                 380                 


Pro Thr Gln Val Val Leu Pro Leu Ser Pro Asn His Gly Leu Phe Gly 
385                 390                 395                 400 


Asn Asp Gly Leu Tyr Ser Glu Ser Lys Ile Ser Leu Glu Thr Leu Phe 
                405                 410                 415     


Asn Arg Trp Ser Ala Glu Ser Trp Gly Glu Tyr Leu Cys Ile Ala Gly 
            420                 425                 430         


Ala Val Ile Gly Trp Thr Arg Gly Thr Gly Leu Met Ser Ala Thr Asn 
        435                 440                 445             


Phe Val Ala Glu Gly Leu Glu Lys Leu Gly Val Arg Thr Phe Ser Ala 
    450                 455                 460                 


Lys Glu Met Ala Phe Asn Ile Leu Gly Leu Met His Pro Leu Ile Phe 
465                 470                 475                 480 


Asp Ile Thr Gln Ile Glu Pro Leu Trp Ala Asp Leu Asn Gly Gly Met 
                485                 490                 495     


Asp Arg Val Ala Gly Leu Ala Asp Val Met Thr Ser Ile Arg Leu Asp 
            500                 505                 510         


Ile Asn Lys Val Ala Asp Leu Arg Lys Ala Ile Ala Leu Asp Asn Gly 
        515                 520                 525             


Ala Asp Phe Lys Val Thr Asn Gly Ser Glu Ala Glu Arg Leu His Gln 
    530                 535                 540                 


Lys Val Ser Val Ala Pro Arg Ala Asn Phe Ser Phe Asp Phe Pro Thr 
545                 550                 555                 560 


Val Glu Asp Asp Ser Val Leu Asn Glu Leu Lys His Leu Glu Gly Leu 
                565                 570                 575     


Ile Asp Leu Asp Lys Val Val Val Cys Thr Gly Phe Ala Glu Ile Gly 
            580                 585                 590         


Pro Trp Gly Ser Ala Arg Thr Arg Trp Glu Met Glu Ala Arg Gly Glu 
        595                 600                 605             


Phe Thr Ile Glu Gly Ile Ile Glu Met Ala Trp Met Met Gly Met Ile 
    610                 615                 620                 


Lys His Phe Glu Gly Met Leu Pro Asn Ala Gly Gly Met Ala Asp Pro 
625                 630                 635                 640 


Tyr Val Gly Trp Val Asp Ala Lys Ser Gly Glu Pro Val Asp Asp Lys 
                645                 650                 655     


Asp Ile Arg Asn Lys Tyr Glu Lys Glu Ile Leu Asn His Ala Gly Ile 
            660                 665                 670         


Arg Ile Ile Glu Pro Asp Leu Phe Phe Gly Tyr Asp Pro Glu Lys Lys 
        675                 680                 685             


Gly Phe Thr Gln Glu Ile Glu Leu Asn His Asp Leu Glu Pro Leu Glu 
    690                 695                 700                 


Val Ser Ala Asp Asp Ala Ala Lys Phe Lys Arg Glu Gln Gly Asp Ala 
705                 710                 715                 720 


Val Asp Ile Trp Ala Gln Asp Ser Gly Glu Trp Phe Val Lys Phe Lys 
                725                 730                 735     


Lys Gly Ala Arg Val Leu Leu Pro Lys Ala Val Lys Phe Asp Arg Val 
            740                 745                 750         


Val Ala Gly Gln Ile Pro Thr Gly Trp Asp Ala Lys Arg Tyr Gly Leu 
        755                 760                 765             


Pro Asp Asp Ile Ile Ser Gln Val Asp Arg Thr Ala Leu Trp Ala Leu 
    770                 775                 780                 


Val Ser Val Thr Glu Ala Leu Ile Met Ser Gly Val Thr Asp Pro Tyr 
785                 790                 795                 800 


Glu Leu Tyr Lys Tyr Ile His Pro Ser Glu Val Gly Thr Ser Leu Gly 
                805                 810                 815     


Ser Gly Met Gly Gly Met Arg Ser Leu Ser Glu Met Phe Lys Gly Arg 
            820                 825                 830         


Arg Glu Glu Lys Asp Val Gln Lys Asp Ile Leu Gln Glu Thr Phe Ile 
        835                 840                 845             


Asn Thr Val Ala Gly Trp Val Asn Leu Leu Leu Met Ser Ala Ser Gly 
    850                 855                 860                 


Pro Val Lys Ile Pro Val Gly Ala Cys Ala Thr Ala Leu Gln Ser Val 
865                 870                 875                 880 


Glu Ile Gly Cys Asp Ser Ile Leu Ser Gly Lys Ala Lys Val Met Ile 
                885                 890                 895     


Ala Gly Gly Tyr Asp Asp Phe Ser Glu Glu Gly Ser Phe Glu Phe Ala 
            900                 905                 910         


Asn Met Lys Ala Thr Ser Asn Ala Glu Thr Glu Phe Ala Asn Gly Arg 
        915                 920                 925             


Glu Pro Asn Glu Phe Ser Arg Pro Met Thr Ser Thr Arg Ala Gly Phe 
    930                 935                 940                 


Met Glu Ser Gln Gly Cys Gly Val His Ile Leu Met Ser Ala Lys Thr 
945                 950                 955                 960 


Ala Ile Glu Met Gly Ala Ser Ile Gln Gly Ile Val Ala Tyr Thr Ser 
                965                 970                 975     


Thr His Thr Asp Lys Ala Gly Arg Ser Val Pro Ala Pro Gly Arg Gly 
            980                 985                 990         


Ile Leu Ser Thr Ala Arg Glu Val  Thr Pro Lys Gln Ser  Leu Pro Ile 
        995                 1000                 1005             


Leu Asp  Leu Lys Tyr Arg Ala  Arg Gln Leu Ala Phe  Arg Arg Lys 
    1010                 1015                 1020             


Gln Ile  Ser Gln Trp Phe Glu  Asn Glu Leu Asp Asn  Leu Arg Asp 
    1025                 1030                 1035             


Glu Ala  Ser Val Ala Gly Lys  Thr Asp Asp Ala Glu  Trp Phe Ala 
    1040                 1045                 1050             


Gln Arg  Val Asp Phe Ile Glu  Arg Glu Ala Lys Arg  Gln Glu Lys 
    1055                 1060                 1065             


Glu Ala  Leu Ala Thr Tyr Gly  Met Leu Glu Gly Ser  Asp Pro Asn 
    1070                 1075                 1080             


Ile Ala  Pro Leu Arg Arg Ala  Leu Ala Val Trp Gly  Leu Asn Ala 
    1085                 1090                 1095             


Asp Ser  Val Gly Val Ile Ser  Cys His Gly Thr Ser  Thr Lys Ala 
    1100                 1105                 1110             


Asn Asp  Lys Asn Glu Ser Gly  Val Tyr Asn Leu Gln  Phe Glu Gln 
    1115                 1120                 1125             


Leu Gly  Arg Ser Lys Gly Asn  Ala Val Pro Val Ile  Thr Gln Lys 
    1130                 1135                 1140             


Tyr Leu  Thr Gly His Pro Lys  Gly Gly Ala Ala Ala  Trp Met Phe 
    1145                 1150                 1155             


Asn Gly  Met Leu Gln Thr Ile  Gln Ser Ala Leu Ile  Pro Gly Asn 
    1160                 1165                 1170             


Ala Asn  Ala Asp Asn Ile Ser  Glu Glu Leu Arg Ala  Phe Pro His 
    1175                 1180                 1185             


Leu Phe  Tyr Pro Ser Lys Ala  Ile Gln His Thr Arg  Leu Glu Ala 
    1190                 1195                 1200             


Gly Leu  Leu Thr Ser Phe Gly  Phe Gly Gln Val Gly  Gly Gln Ala 
    1205                 1210                 1215             


Ala Ile  Leu His Pro Arg Tyr  Leu Phe Ala Ala Ile  Pro Lys Gly 
    1220                 1225                 1230             


Gln Leu  Glu Glu Tyr Lys Lys  Lys Arg His Ala Arg  Gln Leu Asp 
    1235                 1240                 1245             


Ser Tyr  Ala Arg Gln Ser Gln  Ala Met Ile Arg Asn  Asn Leu Val 
    1250                 1255                 1260             


Gln Ile  Lys Asp Ala Pro Pro  Tyr Gly Pro Glu Leu  Glu Gly Pro 
    1265                 1270                 1275             


Val Leu  Leu Asn Pro Leu Ala  Arg Ala Gly Pro Ser  Lys Asn Gly 
    1280                 1285                 1290             


Ser Tyr  Glu Phe Lys Gly Lys  Leu Pro Ser Glu Val  Pro Leu Ser 
    1295                 1300                 1305             


Thr Ala  Asn Ala Asp Thr Ile  Lys Ser Leu Leu Ser  Gln Thr Lys 
    1310                 1315                 1320             


Gly Gly  Ile Ala Gly Val Gly  Val Asp Thr Glu Leu  Ile Ser Ser 
    1325                 1330                 1335             


Val Pro  Thr Ser Asp Ser Phe  Arg Glu Arg Asn Phe  Thr Ala Gly 
    1340                 1345                 1350             


Glu Ile  Glu Tyr Cys Asn Ser  Ala Pro Asp Ser Arg  Ala Ser Tyr 
    1355                 1360                 1365             


Ala Gly  Arg Trp Ala Ala Lys  Glu Ala Val Phe Lys  Ala Leu Ser 
    1370                 1375                 1380             


Val Pro  Ser Lys Gly Ala Gly  Ala Ser Met Lys Asp  Ile Glu Ile 
    1385                 1390                 1395             


Val Ser  Thr Gln Ser Gly Pro  Glu Val Lys Leu His  Gly Asp Ala 
    1400                 1405                 1410             


Ala Lys  Ala Ala Gly Gly Lys  Lys Ile Lys Val Ser  Leu Ser His 
    1415                 1420                 1425             


Ser Asp  Ser Ser Val Val Ala  Phe Ala Val Ala Asn  
    1430                 1435                 1440 


<210>  7
<211>  1438
<212>  PRT
<213>  Cryptococcus neoformans

<400>  7

Met Ala Ala Glu Gly Met Asp Lys Glu Ser Ile Val Arg Arg Glu Leu 
1               5                   10                  15      


Thr Ser Arg Cys Ile Ala Ile Met Asn Arg Ala Asp Pro Ala Leu Leu 
            20                  25                  30          


Asp Tyr Met Lys Tyr His Ile Asp Asn Ala Asp Pro Ser Lys Gly Pro 
        35                  40                  45              


Thr Phe Lys Lys Ile Lys Glu Phe Gly Gln Ile Leu Leu Asp Asn Cys 
    50                  55                  60                  


Lys Glu Val Val Asp Lys Pro Pro Val Tyr Arg Asp Val Ala Leu Pro 
65                  70                  75                  80  


Thr Ala Pro His Thr Glu Ile Ser Ala Lys Gly Asp Ile Ile Tyr Ser 
                85                  90                  95      


Glu Val Ser Arg Gln Asn Val Arg Lys Leu Glu Ser Tyr Val Lys Glu 
            100                 105                 110         


Met Ala Ser Gly Gly Glu Val Glu Pro Ala Val Asn Leu Glu Lys Val 
        115                 120                 125             


Gln Ser Asp Ile Glu Lys Leu Trp Asp Leu Val Asn Ser Gln Pro Ser 
    130                 135                 140                 


Ile Thr Ala Ala Gln Lys Ser Ala Ile Lys Ser Met Tyr Ser Glu Val 
145                 150                 155                 160 


Ile Lys Ser Leu Gly Gln Ser Ser Gly Ser Ala Leu Glu Asp Thr Glu 
                165                 170                 175     


Ser Pro Ala Ile Ala Arg Ala Lys Gly Pro Lys Gln Arg Arg Ser Ser 
            180                 185                 190         


Ser Gln Phe Leu Arg Pro Asn Val Glu Asp Arg Thr Glu Val Glu Glu 
        195                 200                 205             


Ala His Leu Pro Phe Leu His Leu Lys Arg Lys Thr Gly Thr Ser Phe 
    210                 215                 220                 


Ser Tyr Ser Ala Lys Leu Thr Asn Ile Tyr Phe Asp Val Leu Thr Glu 
225                 230                 235                 240 


Ile Ala Thr Ser Gly Val Thr Phe Ala Lys Lys Ala Ala Leu Leu Thr 
                245                 250                 255     


Gly Val Gly Lys Gly Ser Ile Gly Val Glu Ile Leu Lys Gly Leu Leu 
            260                 265                 270         


Ser Gly Gly Cys Thr Cys Ile Val Thr Thr Ser Arg Tyr Ser Arg Ala 
        275                 280                 285             


Ala Val Asp Tyr Tyr Lys Asn Ile Phe His Glu Ile Gly Ser Lys Gly 
    290                 295                 300                 


Ser Lys Leu Ile Val Val Pro Phe Asn Gly Ala Ser Arg Gln Asp Val 
305                 310                 315                 320 


Glu Ala Leu Val Asp Tyr Ile Tyr Ser Thr Leu Gln Ile Asp Leu Asp 
                325                 330                 335     


Tyr Ile Ile Pro Phe Ala Ala Leu Pro Glu Asn Gly Arg Glu Ile Asp 
            340                 345                 350         


Ser Ile Asp Asp Lys Ser Glu Leu Ala His Arg Leu Met Leu Thr Asn 
        355                 360                 365             


Leu Leu Arg Leu Leu Gly Ala Val Lys Gln Lys Lys Ala Ala Arg Gln 
    370                 375                 380                 


Phe Val Thr Arg Pro Thr Gln Val Val Leu Pro Leu Ser Pro Asn His 
385                 390                 395                 400 


Gly Ile Phe Gly Asn Asp Gly Leu Tyr Ser Glu Ser Lys Ile Ser Leu 
                405                 410                 415     


Glu Thr Leu Phe Asn Arg Trp Ser Ala Glu Ser Trp Gly Glu Tyr Leu 
            420                 425                 430         


Cys Ile Ala Gly Ala Val Ile Gly Trp Thr Arg Gly Thr Gly Leu Met 
        435                 440                 445             


Ser Ala Thr Asn Phe Val Ala Glu Gly Leu Glu Lys Leu Gly Val Arg 
    450                 455                 460                 


Thr Phe Ser Ala Lys Glu Met Ala Phe Asn Ile Leu Gly Leu Met His 
465                 470                 475                 480 


Pro Leu Leu Phe Asp Ile Thr Gln Ile Glu Pro Ile Trp Ala Asp Leu 
                485                 490                 495     


Asn Gly Gly Met Asp Arg Val Ala Gly Leu Ala Glu Val Met Thr Ser 
            500                 505                 510         


Ile Arg Val Asp Ile Asn Arg Val Ala Glu Leu Arg Lys Ala Ile Thr 
        515                 520                 525             


Ile Asp Asn Ala Ala Asp Phe Arg Val Ile Asn Gly Gly Asp Ala Glu 
    530                 535                 540                 


Arg Leu His Gln Lys Val Ala Ile Ala Pro Arg Ala Asn Phe Ser Phe 
545                 550                 555                 560 


Asp Phe Pro Lys Ile Asp Gly Asp Asp Ile Leu Asn Glu Leu Lys His 
                565                 570                 575     


Leu Gln Gly Leu Ile Asp Leu Asp Lys Val Ile Val Cys Thr Gly Phe 
            580                 585                 590         


Ser Glu Val Gly Pro Trp Gly Ser Ser Arg Thr Arg Trp Glu Met Glu 
        595                 600                 605             


Ala Arg Gly Glu Phe Ser Ile Glu Gly Cys Ile Glu Met Ala Trp Met 
    610                 615                 620                 


Met Gly Phe Ile Lys His Leu Asp Gly Lys Leu Ala Asn Gly Gln Thr 
625                 630                 635                 640 


Tyr Val Gly Trp Val Asp Ala Lys Ser Gly Glu Pro Val Asp Asp Lys 
                645                 650                 655     


Asp Val Lys Thr Lys Tyr Glu Lys Asp Ile Ile Lys His Ala Gly Ile 
            660                 665                 670         


Arg Leu Ile Glu Pro Asp Leu Phe Trp Gly Tyr Asn Pro Glu Lys Lys 
        675                 680                 685             


Gly Phe Ile Gln Glu Ile Glu Leu Asn His Asp Leu Glu Pro Leu Glu 
    690                 695                 700                 


Val Ala Ala Glu Glu Ala Ala Arg Phe Lys Arg Glu His Gly Asp Lys 
705                 710                 715                 720 


Val Asp Ile Trp Ala Gln Glu Ser Gly Glu Trp Phe Val Lys Phe Asn 
                725                 730                 735     


Lys Gly Ala Arg Ile Phe Leu Pro Lys Ala Val Lys Phe Asp Arg Val 
            740                 745                 750         


Val Ala Gly Gln Leu Pro Thr Gly Trp Asp Ala Arg Arg Phe Gly Leu 
        755                 760                 765             


Pro Glu Asp Ile Ile Ala Gln Thr Asp Arg Thr Ala Leu Trp Ala Leu 
    770                 775                 780                 


Val Cys Thr Met Glu Ala Leu Ile Met Ser Gly Val Thr Asp Pro Tyr 
785                 790                 795                 800 


Glu Leu Tyr Lys Tyr Ile His Pro Ser Glu Val Gly Thr Ser Leu Gly 
                805                 810                 815     


Ser Gly Met Gly Gly Met His Ser Met Ser Ala Met Phe Lys Asp Arg 
            820                 825                 830         


Arg Glu Glu Arg Asp Val Gln Lys Asp Ile Leu Gln Glu Thr Phe Ile 
        835                 840                 845             


Asn Thr Val Ala Gly Trp Val Asn Leu Leu Leu Leu Ser Ser Ser Gly 
    850                 855                 860                 


Pro Val Lys Ile Pro Val Gly Ala Cys Ala Thr Ala Leu Gln Ser Val 
865                 870                 875                 880 


Glu Ile Ala Cys Asp Thr Ile Leu Thr Gly Lys Ala Lys Ile Met Ile 
                885                 890                 895     


Ala Gly Gly Phe Asp Asp Phe Ser Glu Glu Gly Ser Phe Glu Phe Ala 
            900                 905                 910         


Asn Met Lys Ala Thr Ser Asn Ala Glu Thr Glu Phe Ala Met Gly Arg 
        915                 920                 925             


Glu Pro Asn Glu Phe Ser Arg Pro Met Thr Ser Thr Arg Ala Gly Phe 
    930                 935                 940                 


Met Glu Ser Gln Gly Cys Gly Val His Val Met Met Ser Ala Lys Thr 
945                 950                 955                 960 


Ala Ile Glu Met Gly Ala Ser Ile Gln Gly Ile Val Ala Tyr Thr Ser 
                965                 970                 975     


Thr His Thr Asp Lys Ala Gly Arg Ser Ile Pro Ala Pro Gly Arg Gly 
            980                 985                 990         


Ile Leu Ser Thr Ala Arg Glu Val  Thr Pro Lys Glu Ala  Leu Pro Leu 
        995                 1000                 1005             


Leu Asp  Ile Lys Tyr Arg Ser  Arg Gln Leu Ala Phe  Arg Arg Lys 
    1010                 1015                 1020             


Gln Ile  Ser Gln Trp Leu Glu  Asn Glu His Glu Leu  Leu Arg Met 
    1025                 1030                 1035             


Glu Leu  Glu Thr Arg Lys Gly  Gly Asp Asn Glu Asp  Trp Phe Gln 
    1040                 1045                 1050             


Asn Arg  Val Ala Phe Ile Asp  Asp Glu Ala Lys Arg  Gln Glu Lys 
    1055                 1060                 1065             


Asp Ala  Leu Ala Thr Phe Gly  Met Leu Glu Gly Ser  His Pro Asn 
    1070                 1075                 1080             


Ile Ala  Pro Leu Arg Arg Ala  Leu Ala Val Trp Gly  Leu Asp Ala 
    1085                 1090                 1095             


Asp Ser  Val Gly Ala Ile Ser  Cys His Gly Thr Ser  Thr Lys Ala 
    1100                 1105                 1110             


Asn Asp  Lys Asn Glu Ser Gly  Val Tyr Asn Leu Gln  Phe Glu Gln 
    1115                 1120                 1125             


Leu Gly  Arg Thr Pro Gly Asn  Ala Val Pro Val Ile  Ala Gln Lys 
    1130                 1135                 1140             


Ser Leu  Thr Gly His Pro Lys  Gly Gly Ala Ala Ala  Trp Met Phe 
    1145                 1150                 1155             


Asn Gly  Met Cys Gln Thr Ile  Asn Ser Ala Leu Val  Pro Gly Asn 
    1160                 1165                 1170             


His Asn  Ala Asp Asn Ile Ser  Glu Glu Leu Arg Ala  Phe Arg His 
    1175                 1180                 1185             


Leu Phe  Tyr Pro Ser Lys Pro  Ile Gln His Val Arg  Leu Glu Cys 
    1190                 1195                 1200             


Gly Leu  Leu Thr Ser Phe Gly  Phe Gly Gln Val Gly  Gly Gln Val 
    1205                 1210                 1215             


Ala Ile  Val His Pro Arg Tyr  Leu Phe Ala Ala Leu  Gln Ala His 
    1220                 1225                 1230             


Glu Leu  Glu Ala Tyr Lys Lys  Arg Arg Gln Ala Arg  Glu Leu Asp 
    1235                 1240                 1245             


Thr Tyr  Ser Arg Met Ser Ser  Ala Ile Val Asn Asn  Asn Met Val 
    1250                 1255                 1260             


Gln Ile  Lys Glu Gly Pro Pro  Tyr Thr Ala Glu Leu  Glu Ser Lys 
    1265                 1270                 1275             


Val Leu  Leu Asn Pro Leu Ala  Arg Ala Gly Pro Ser  Lys Asn Ser 
    1280                 1285                 1290             


Phe Ala  Phe Gln Gly Lys Leu  Pro Ala Lys Val Pro  Val Asp Ile 
    1295                 1300                 1305             


Lys Asn  Ala Glu Thr Leu Lys  Ala Met Phe Asp Gln  Ala Gly Ala 
    1310                 1315                 1320             


Leu Ser  Gly Val Gly Val Asp  Thr Glu Leu Ile Ser  Ser Val Pro 
    1325                 1330                 1335             


Thr Ser  Glu Thr Phe Arg Glu  Arg Asn Phe Thr Ala  Asp Glu Ile 
    1340                 1345                 1350             


Ser Tyr  Cys Asn Ser Ala Ala  Asp Pro Thr Ala Ser  Phe Ala Gly 
    1355                 1360                 1365             


Arg Trp  Ala Ala Lys Glu Ala  Val Phe Lys Ala Leu  Ser Val Pro 
    1370                 1375                 1380             


Ser Lys  Gly Ala Gly Ala Pro  Leu Lys Glu Ile Glu  Ile Val Ser 
    1385                 1390                 1395             


Thr Ser  Ser Gly Pro Thr Val  Lys Leu Ser Gly Asp  Ala Leu Ala 
    1400                 1405                 1410             


Ala Ala  Gly Gly Lys Ser Val  Lys Val Ser Leu Ser  His Ser Asp 
    1415                 1420                 1425             


Thr Ser  Val Val Ala Phe Ala  Val Ala Gln 
    1430                 1435             


<210>  8
<211>  1438
<212>  PRT
<213>  Cryptococcus gattii

<400>  8

Met Ala Ala Glu Gly Met Asp Lys Glu Ser Ile Val Arg Arg Glu Leu 
1               5                   10                  15      


Thr Ser Arg Cys Ile Ala Ile Met Asn Arg Ala Asp Pro Ala Leu Leu 
            20                  25                  30          


Glu Tyr Met Lys Tyr His Ile Asp Asn Ala Asp Pro Ser Lys Gly Pro 
        35                  40                  45              


Thr Phe Lys Lys Ile Lys Glu Phe Gly Gln Ile Leu Leu Asp Asn Cys 
    50                  55                  60                  


Lys Glu Val Val Asp Lys Pro Pro Val Tyr Arg Asp Val Ala Leu Pro 
65                  70                  75                  80  


Thr Ala Pro His Thr Glu Val Ser Ala Lys Gly Asp Ile Ile Tyr Ser 
                85                  90                  95      


Glu Val Ser Arg Gln Asn Val Arg Lys Leu Glu Ser Tyr Val Lys Glu 
            100                 105                 110         


Met Ala Ser Gly Gly Glu Val Glu Pro Ala Val Asn Leu Glu Lys Val 
        115                 120                 125             


Gln Ser Asp Ile Glu Lys Leu Trp Glu Leu Val Asn Ser Gln Pro Ser 
    130                 135                 140                 


Ile Thr Ala Ala Gln Lys Ser Ala Ile Lys Ser Met Tyr Ser Glu Val 
145                 150                 155                 160 


Ile Lys Ser Leu Gly Gln Ser Ser Gly Ser Ala Val Glu Asp Ala Glu 
                165                 170                 175     


Ser Pro Ala Ile Ala Arg Thr Lys Gly Thr Lys Gln Arg Arg Ser Ser 
            180                 185                 190         


Ser Gln Phe Leu Arg Pro Asn Val Glu Asp Arg Thr Glu Val Glu Glu 
        195                 200                 205             


Thr His Leu Pro Phe Leu His Leu Lys Arg Lys Thr Gly Thr Ser Phe 
    210                 215                 220                 


Ser Tyr Ser Ala Lys Leu Thr Asn Ile Tyr Phe Asp Val Leu Thr Glu 
225                 230                 235                 240 


Ile Ala Thr Ser Gly Val Thr Phe Ala Lys Lys Ala Ala Leu Leu Thr 
                245                 250                 255     


Gly Val Gly Lys Gly Ser Ile Gly Val Glu Ile Leu Lys Gly Leu Leu 
            260                 265                 270         


Ser Gly Gly Cys Thr Cys Ile Val Thr Thr Ser Arg Tyr Ser Arg Ala 
        275                 280                 285             


Ala Val Asp Tyr Tyr Lys Ser Ile Phe His Glu Leu Gly Ser Lys Gly 
    290                 295                 300                 


Ser Lys Leu Ile Val Val Pro Phe Asn Gly Ala Ser Arg Gln Asp Val 
305                 310                 315                 320 


Glu Ala Leu Val Asp Tyr Ile Tyr Ser Thr Leu Gln Ile Asp Leu Asp 
                325                 330                 335     


Tyr Ile Ile Pro Phe Ala Ala Leu Pro Glu Asn Gly Arg Glu Ile Asp 
            340                 345                 350         


Ser Ile Asp Asp Lys Ser Glu Leu Ala His Arg Leu Met Leu Thr Asn 
        355                 360                 365             


Leu Leu Arg Leu Leu Gly Ala Val Lys Gln Lys Lys Ala Ala Arg Gln 
    370                 375                 380                 


Phe Val Thr Arg Pro Thr Gln Val Val Leu Pro Leu Ser Pro Asn His 
385                 390                 395                 400 


Gly Ile Phe Gly Asn Asp Gly Leu Tyr Ser Glu Ser Lys Ile Ser Leu 
                405                 410                 415     


Glu Thr Leu Phe Asn Arg Trp Ser Ala Glu Ser Trp Gly Glu Tyr Leu 
            420                 425                 430         


Cys Ile Ala Gly Ala Val Ile Gly Trp Thr Arg Gly Thr Gly Leu Met 
        435                 440                 445             


Ser Ala Thr Asn Phe Val Ala Glu Gly Leu Glu Lys Leu Gly Val Arg 
    450                 455                 460                 


Thr Phe Ser Pro Lys Glu Met Ala Phe Asn Ile Leu Gly Leu Met His 
465                 470                 475                 480 


Pro Leu Leu Phe Asp Ile Thr Gln Ile Glu Pro Ile Trp Ala Asp Leu 
                485                 490                 495     


Asn Gly Gly Met Asp Arg Val Ala Gly Leu Ala Glu Val Met Thr Ser 
            500                 505                 510         


Ile Arg Val Asp Ile Asn Arg Met Ala Glu Leu Arg Lys Ala Ile Thr 
        515                 520                 525             


Leu Asp Asn Ser Ala Asp Phe Arg Val Ile Asn Gly Gly Asp Ala Glu 
    530                 535                 540                 


Arg Leu Tyr Gln Lys Val Ala Ile Ala Pro Arg Ala Asn Phe Ser Phe 
545                 550                 555                 560 


Asp Phe Pro Lys Ile Asp Gly Asp Asp Ile Leu Asn Glu Leu Lys His 
                565                 570                 575     


Leu Gln Gly Leu Ile Asp Leu Asp Lys Val Ile Val Cys Thr Gly Phe 
            580                 585                 590         


Ala Glu Val Gly Pro Trp Gly Ser Ser Arg Thr Arg Trp Glu Met Glu 
        595                 600                 605             


Ala Arg Gly Glu Phe Thr Ile Glu Gly Cys Ile Glu Met Ala Trp Met 
    610                 615                 620                 


Met Gly Phe Ile Lys His Leu Asp Gly Lys Leu Gly Asn Gly Gln Thr 
625                 630                 635                 640 


Tyr Val Gly Trp Val Asp Ala Lys Ser Gly Glu Pro Val Asp Asp Lys 
                645                 650                 655     


Asp Val Lys Thr Lys Tyr Glu Lys Asp Ile Ile Lys His Ala Gly Ile 
            660                 665                 670         


Arg Leu Ile Glu Pro Asp Leu Phe Trp Gly Tyr Asn Pro Glu Lys Lys 
        675                 680                 685             


Gly Phe Ile Gln Glu Ile Glu Leu Asn His Asp Leu Glu Pro Leu Glu 
    690                 695                 700                 


Val Ala Ala Glu Glu Ala Ala Arg Phe Lys Arg Glu His Gly Asp Lys 
705                 710                 715                 720 


Val Asp Val Trp Ala Gln Glu Ser Gly Glu Trp Phe Val Lys Phe Asn 
                725                 730                 735     


Lys Gly Ala Arg Ile Phe Leu Pro Lys Ala Val Lys Phe Asp Arg Val 
            740                 745                 750         


Val Ala Gly Gln Leu Pro Thr Gly Trp Asp Ala Arg Arg Phe Gly Leu 
        755                 760                 765             


Pro Asp Asp Ile Ile Ala Gln Thr Asp Arg Thr Ala Leu Trp Ala Leu 
    770                 775                 780                 


Val Cys Thr Met Glu Ala Leu Ile Met Ser Gly Val Thr Asp Pro Tyr 
785                 790                 795                 800 


Glu Leu Tyr Lys Tyr Ile His Pro Ser Glu Val Gly Thr Ser Leu Gly 
                805                 810                 815     


Ser Gly Met Gly Gly Met His Ser Met Ser Ala Met Phe Lys Asp Arg 
            820                 825                 830         


Arg Glu Glu Arg Asp Val Gln Lys Asp Ile Leu Gln Glu Thr Phe Ile 
        835                 840                 845             


Asn Thr Val Ala Gly Trp Val Asn Leu Leu Leu Leu Ser Ser Ser Gly 
    850                 855                 860                 


Pro Val Lys Ile Pro Val Gly Ala Cys Ala Thr Ala Leu Gln Ser Val 
865                 870                 875                 880 


Glu Ile Ala Cys Asp Thr Ile Ile Ser Gly Lys Ala Lys Val Met Ile 
                885                 890                 895     


Ala Gly Gly Phe Asp Asp Phe Ser Glu Glu Gly Ser Phe Glu Phe Ala 
            900                 905                 910         


Asn Met Lys Ala Thr Ser Asn Ala Glu Thr Glu Phe Ala Met Gly Arg 
        915                 920                 925             


Glu Pro Asn Glu Phe Ser Arg Pro Met Thr Ser Thr Arg Ala Gly Phe 
    930                 935                 940                 


Met Glu Ser Gln Gly Cys Gly Val His Val Met Met Ser Ala Lys Thr 
945                 950                 955                 960 


Ala Ile Glu Met Gly Ala Ser Ile Gln Gly Ile Val Ala Tyr Ser Ser 
                965                 970                 975     


Thr His Thr Asp Lys Ala Gly Arg Ser Ile Pro Ala Pro Gly Arg Gly 
            980                 985                 990         


Ile Leu Ser Thr Ala Arg Glu Ile  Thr Pro Lys Glu Ala  Leu Pro Leu 
        995                 1000                 1005             


Leu Asp  Val Lys Tyr Arg Ser  Arg Gln Leu Ala Phe  Arg Arg Lys 
    1010                 1015                 1020             


Gln Ile  Ser Gln Trp Leu Glu  Asn Glu His Glu Leu  Leu Arg Met 
    1025                 1030                 1035             


Glu Leu  Glu Thr Arg Lys Gly  Gly Asp Asn Glu Glu  Trp Phe Gln 
    1040                 1045                 1050             


Asn Arg  Val Ala Phe Ile Asp  Asp Glu Ala Lys Arg  Gln Glu Lys 
    1055                 1060                 1065             


Glu Ala  Leu Ala Thr Phe Gly  Met Leu Glu Gly Ser  His Pro Asn 
    1070                 1075                 1080             


Val Ala  Pro Leu Arg Arg Ala  Leu Ala Val Trp Gly  Leu Asp Ala 
    1085                 1090                 1095             


Asp Ser  Val Gly Ala Ile Ser  Cys His Gly Thr Ser  Thr Lys Ala 
    1100                 1105                 1110             


Asn Asp  Lys Asn Glu Ser Gly  Val Tyr Asn Leu Gln  Phe Glu Gln 
    1115                 1120                 1125             


Leu Gly  Arg Thr Pro Gly Asn  Ala Val Pro Val Ile  Ala Gln Lys 
    1130                 1135                 1140             


Ser Leu  Thr Gly His Pro Lys  Gly Gly Ala Ala Ala  Trp Met Phe 
    1145                 1150                 1155             


Asn Gly  Met Cys Gln Thr Ile  Asn Ser Ala Leu Val  Pro Gly Asn 
    1160                 1165                 1170             


His Asn  Ala Asp Asn Ile Ser  Glu Glu Leu Arg Ala  Phe Pro His 
    1175                 1180                 1185             


Leu Phe  Tyr Pro Ser Lys Pro  Ile Gln His Val Arg  Leu Glu Cys 
    1190                 1195                 1200             


Gly Leu  Leu Thr Ser Phe Gly  Phe Gly Gln Val Gly  Gly Gln Ile 
    1205                 1210                 1215             


Ala Ile  Val His Pro Arg Tyr  Leu Phe Ala Ala Leu  Gln Ala His 
    1220                 1225                 1230             


Glu Leu  Glu Ala Tyr Lys Lys  Arg Arg Gln Asp Arg  Glu Leu Asp 
    1235                 1240                 1245             


Thr Tyr  Ser Arg Met Ser Ser  Ala Leu Val Asn Asn  Asn Met Val 
    1250                 1255                 1260             


Gln Ile  Lys Glu Gly Pro Pro  Tyr Thr Ala Glu Leu  Glu Gly Gly 
    1265                 1270                 1275             


Val Leu  Leu Asn Pro Leu Ala  Arg Ala Gly Pro Ser  Lys Asn Ser 
    1280                 1285                 1290             


Phe Ala  Phe Gln Gly Lys Leu  Pro Thr Lys Val Pro  Val Asp Val 
    1295                 1300                 1305             


Lys Asn  Ala Glu Thr Leu Lys  Ala Met Phe Asp Gln  Ala Gly Ala 
    1310                 1315                 1320             


Leu Ser  Gly Val Gly Val Asp  Thr Glu Leu Ile Ser  Ser Val Pro 
    1325                 1330                 1335             


Thr Ser  Glu Thr Phe Arg Glu  Arg Asn Phe Thr Ala  Asp Glu Ile 
    1340                 1345                 1350             


Ser Tyr  Cys Ser Ser Ala Ala  Asp Pro Val Ala Ser  Phe Ala Gly 
    1355                 1360                 1365             


Arg Trp  Ala Ala Lys Glu Ala  Val Phe Lys Ala Leu  Ser Val Pro 
    1370                 1375                 1380             


Ser Lys  Gly Ala Gly Ala Pro  Leu Lys Glu Ile Glu  Ile Val Ser 
    1385                 1390                 1395             


Thr Pro  Ser Gly Pro Thr Val  Lys Leu Ser Gly Asp  Ala Leu Ala 
    1400                 1405                 1410             


Ala Ala  Gly Gly Lys Ser Val  Lys Val Ser Leu Ser  His Ser Asp 
    1415                 1420                 1425             


Thr Ser  Val Val Ala Phe Ala  Val Ala Gln 
    1430                 1435             


<210>  9
<211>  1887
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  9

Met Lys Pro Glu Val Glu Gln Glu Leu Ala His Ile Leu Leu Thr Glu 
1               5                   10                  15      


Leu Leu Ala Tyr Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln 
            20                  25                  30          


Asp Val Phe Leu Lys Asp Phe Asn Thr Glu Arg Val Val Glu Ile Gly 
        35                  40                  45              


Pro Ser Pro Thr Leu Ala Gly Met Ala Gln Arg Thr Leu Lys Asn Lys 
    50                  55                  60                  


Tyr Glu Ser Tyr Asp Ala Ala Leu Ser Leu His Arg Glu Ile Leu Cys 
65                  70                  75                  80  


Tyr Ser Lys Asp Ala Lys Glu Ile Tyr Tyr Thr Pro Asp Pro Ser Glu 
                85                  90                  95      


Leu Ala Ala Lys Glu Glu Pro Ala Lys Glu Glu Ala Pro Ala Pro Thr 
            100                 105                 110         


Pro Ala Ala Ser Ala Pro Ala Pro Ala Ala Ala Ala Pro Ala Pro Val 
        115                 120                 125             


Ala Ala Ala Ala Pro Ala Ala Ala Ala Ala Glu Ile Ala Asp Glu Pro 
    130                 135                 140                 


Val Lys Ala Ser Leu Leu Leu His Val Leu Val Ala His Lys Leu Lys 
145                 150                 155                 160 


Lys Ser Leu Asp Ser Ile Pro Met Ser Lys Thr Ile Lys Asp Leu Val 
                165                 170                 175     


Gly Gly Lys Ser Thr Val Gln Asn Glu Ile Leu Gly Asp Leu Gly Lys 
            180                 185                 190         


Glu Phe Gly Thr Thr Pro Glu Lys Pro Glu Glu Thr Pro Leu Glu Glu 
        195                 200                 205             


Leu Ala Glu Thr Phe Gln Asp Thr Phe Ser Gly Ala Leu Gly Lys Gln 
    210                 215                 220                 


Ser Ser Ser Leu Leu Ser Arg Leu Ile Ser Ser Lys Met Pro Gly Gly 
225                 230                 235                 240 


Phe Thr Ile Thr Val Ala Arg Lys Tyr Leu Gln Thr Arg Trp Gly Leu 
                245                 250                 255     


Pro Ser Gly Arg Gln Asp Gly Val Leu Leu Val Ala Leu Ser Asn Glu 
            260                 265                 270         


Pro Ala Ala Arg Leu Gly Ser Glu Ala Asp Ala Lys Ala Phe Leu Asp 
        275                 280                 285             


Ser Met Ala Gln Lys Tyr Ala Ser Ile Val Gly Val Asp Leu Ser Ser 
    290                 295                 300                 


Ala Ala Ser Ala Ser Gly Ala Ala Gly Ala Gly Ala Ala Ala Gly Ala 
305                 310                 315                 320 


Ala Met Ile Asp Ala Gly Ala Leu Glu Glu Ile Thr Lys Asp His Lys 
                325                 330                 335     


Val Leu Ala Arg Gln Gln Leu Gln Val Leu Ala Arg Tyr Leu Lys Met 
            340                 345                 350         


Asp Leu Asp Asn Gly Glu Arg Lys Phe Leu Lys Glu Lys Asp Thr Val 
        355                 360                 365             


Ala Glu Leu Gln Ala Gln Leu Asp Tyr Leu Asn Ala Glu Leu Gly Glu 
    370                 375                 380                 


Phe Phe Val Asn Gly Val Ala Thr Ser Phe Ser Arg Lys Lys Ala Arg 
385                 390                 395                 400 


Thr Phe Asp Ser Ser Trp Asn Trp Ala Lys Gln Ser Leu Leu Ser Leu 
                405                 410                 415     


Tyr Phe Glu Ile Ile His Gly Val Leu Lys Asn Val Asp Arg Glu Val 
            420                 425                 430         


Val Ser Glu Ala Ile Asn Ile Met Asn Arg Ser Asn Asp Ala Leu Ile 
        435                 440                 445             


Lys Phe Met Glu Tyr His Ile Ser Asn Thr Asp Glu Thr Lys Gly Glu 
    450                 455                 460                 


Asn Tyr Gln Leu Val Lys Thr Leu Gly Glu Gln Leu Ile Glu Asn Cys 
465                 470                 475                 480 


Lys Gln Val Leu Asp Val Asp Pro Val Tyr Lys Asp Val Ala Lys Pro 
                485                 490                 495     


Thr Gly Pro Lys Thr Ala Ile Asp Lys Asn Gly Asn Ile Thr Tyr Ser 
            500                 505                 510         


Glu Glu Pro Arg Glu Lys Val Arg Lys Leu Ser Gln Tyr Val Gln Glu 
        515                 520                 525             


Met Ala Leu Gly Gly Pro Ile Thr Lys Glu Ser Gln Pro Thr Ile Glu 
    530                 535                 540                 


Glu Asp Leu Thr Arg Val Tyr Lys Ala Ile Ser Ala Gln Ala Asp Lys 
545                 550                 555                 560 


Gln Asp Ile Ser Ser Ser Thr Arg Val Glu Phe Glu Lys Leu Tyr Ser 
                565                 570                 575     


Asp Leu Met Lys Phe Leu Glu Ser Ser Lys Glu Ile Asp Pro Ser Gln 
            580                 585                 590         


Thr Thr Gln Leu Ala Gly Met Asp Val Glu Asp Ala Leu Asp Lys Asp 
        595                 600                 605             


Ser Thr Lys Glu Val Ala Ser Leu Pro Asn Lys Ser Thr Ile Ser Lys 
    610                 615                 620                 


Thr Val Ser Ser Thr Ile Pro Arg Glu Thr Ile Pro Phe Leu His Leu 
625                 630                 635                 640 


Arg Lys Lys Thr Pro Ala Gly Asp Trp Lys Tyr Asp Arg Gln Leu Ser 
                645                 650                 655     


Ser Leu Phe Leu Asp Gly Leu Glu Lys Ala Ala Phe Asn Gly Val Thr 
            660                 665                 670         


Phe Lys Asp Lys Tyr Val Leu Ile Thr Gly Ala Gly Lys Gly Ser Ile 
        675                 680                 685             


Gly Ala Glu Val Leu Gln Gly Leu Leu Gln Gly Gly Ala Lys Val Val 
    690                 695                 700                 


Val Thr Thr Ser Arg Phe Ser Lys Gln Val Thr Asp Tyr Tyr Gln Ser 
705                 710                 715                 720 


Ile Tyr Ala Lys Tyr Gly Ala Lys Gly Ser Thr Leu Ile Val Val Pro 
                725                 730                 735     


Phe Asn Gln Gly Ser Lys Gln Asp Val Glu Ala Leu Ile Glu Phe Ile 
            740                 745                 750         


Tyr Asp Thr Glu Lys Asn Gly Gly Leu Gly Trp Asp Leu Asp Ala Ile 
        755                 760                 765             


Ile Pro Phe Ala Ala Ile Pro Glu Gln Gly Ile Glu Leu Glu His Ile 
    770                 775                 780                 


Asp Ser Lys Ser Glu Phe Ala His Arg Ile Met Leu Thr Asn Ile Leu 
785                 790                 795                 800 


Arg Met Met Gly Cys Val Lys Lys Gln Lys Ser Ala Arg Gly Ile Glu 
                805                 810                 815     


Thr Arg Pro Ala Gln Val Ile Leu Pro Met Ser Pro Asn His Gly Thr 
            820                 825                 830         


Phe Gly Gly Asp Gly Met Tyr Ser Glu Ser Lys Leu Ser Leu Glu Thr 
        835                 840                 845             


Leu Phe Asn Arg Trp His Ser Glu Ser Trp Ala Asn Gln Leu Thr Val 
    850                 855                 860                 


Cys Gly Ala Ile Ile Gly Trp Thr Arg Gly Thr Gly Leu Met Ser Ala 
865                 870                 875                 880 


Asn Asn Ile Ile Ala Glu Gly Ile Glu Lys Met Gly Val Arg Thr Phe 
                885                 890                 895     


Ser Gln Lys Glu Met Ala Phe Asn Leu Leu Gly Leu Leu Thr Pro Glu 
            900                 905                 910         


Val Val Glu Leu Cys Gln Lys Ser Pro Val Met Ala Asp Leu Asn Gly 
        915                 920                 925             


Gly Leu Gln Phe Val Pro Glu Leu Lys Glu Phe Thr Ala Lys Leu Arg 
    930                 935                 940                 


Lys Glu Leu Val Glu Thr Ser Glu Val Arg Lys Ala Val Ser Ile Glu 
945                 950                 955                 960 


Thr Ala Leu Glu His Lys Val Val Asn Gly Asn Ser Ala Asp Ala Ala 
                965                 970                 975     


Tyr Ala Gln Val Glu Ile Gln Pro Arg Ala Asn Ile Gln Leu Asp Phe 
            980                 985                 990         


Pro Glu Leu Lys Pro Tyr Lys Gln  Val Lys Gln Ile Ala  Pro Ala Glu 
        995                 1000                 1005             


Leu Glu  Gly Leu Leu Asp Leu  Glu Arg Val Ile Val  Val Thr Gly 
    1010                 1015                 1020             


Phe Ala  Glu Val Gly Pro Trp  Gly Ser Ala Arg Thr  Arg Trp Glu 
    1025                 1030                 1035             


Met Glu  Ala Phe Gly Glu Phe  Ser Leu Glu Gly Cys  Val Glu Met 
    1040                 1045                 1050             


Ala Trp  Ile Met Gly Phe Ile  Ser Tyr His Asn Gly  Asn Leu Lys 
    1055                 1060                 1065             


Gly Arg  Pro Tyr Thr Gly Trp  Val Asp Ser Lys Thr  Lys Glu Pro 
    1070                 1075                 1080             


Val Asp  Asp Lys Asp Val Lys  Ala Lys Tyr Glu Thr  Ser Ile Leu 
    1085                 1090                 1095             


Glu His  Ser Gly Ile Arg Leu  Ile Glu Pro Glu Leu  Phe Asn Gly 
    1100                 1105                 1110             


Tyr Asn  Pro Glu Lys Lys Glu  Met Ile Gln Glu Val  Ile Val Glu 
    1115                 1120                 1125             


Glu Asp  Leu Glu Pro Phe Glu  Ala Ser Lys Glu Thr  Ala Glu Gln 
    1130                 1135                 1140             


Phe Lys  His Gln His Gly Asp  Lys Val Asp Ile Phe  Glu Ile Pro 
    1145                 1150                 1155             


Glu Thr  Gly Glu Tyr Ser Val  Lys Leu Leu Lys Gly  Ala Thr Leu 
    1160                 1165                 1170             


Tyr Ile  Pro Lys Ala Leu Arg  Phe Asp Arg Leu Val  Ala Gly Gln 
    1175                 1180                 1185             


Ile Pro  Thr Gly Trp Asn Ala  Lys Thr Tyr Gly Ile  Ser Asp Asp 
    1190                 1195                 1200             


Ile Ile  Ser Gln Val Asp Pro  Ile Thr Leu Phe Val  Leu Val Ser 
    1205                 1210                 1215             


Val Val  Glu Ala Phe Ile Ala  Ser Gly Ile Thr Asp  Pro Tyr Glu 
    1220                 1225                 1230             


Met Tyr  Lys Tyr Val His Val  Ser Glu Val Gly Asn  Cys Ser Gly 
    1235                 1240                 1245             


Ser Gly  Met Gly Gly Val Ser  Ala Leu Arg Gly Met  Phe Lys Asp 
    1250                 1255                 1260             


Arg Phe  Lys Asp Glu Pro Val  Gln Asn Asp Ile Leu  Gln Glu Ser 
    1265                 1270                 1275             


Phe Ile  Asn Thr Met Ser Ala  Trp Val Asn Met Leu  Leu Ile Ser 
    1280                 1285                 1290             


Ser Ser  Gly Pro Ile Lys Thr  Pro Val Gly Ala Cys  Ala Thr Ser 
    1295                 1300                 1305             


Val Glu  Ser Val Asp Ile Gly  Val Glu Thr Ile Leu  Ser Gly Lys 
    1310                 1315                 1320             


Ala Arg  Ile Cys Ile Val Gly  Gly Tyr Asp Asp Phe  Gln Glu Glu 
    1325                 1330                 1335             


Gly Ser  Phe Glu Phe Gly Asn  Met Lys Ala Thr Ser  Asn Thr Leu 
    1340                 1345                 1350             


Glu Glu  Phe Glu His Gly Arg  Thr Pro Ala Glu Met  Ser Arg Pro 
    1355                 1360                 1365             


Ala Thr  Thr Thr Arg Asn Gly  Phe Met Glu Ala Gln  Gly Ala Gly 
    1370                 1375                 1380             


Ile Gln  Ile Ile Met Gln Ala  Asp Leu Ala Leu Lys  Met Gly Val 
    1385                 1390                 1395             


Pro Ile  Tyr Gly Ile Val Ala  Met Ala Ala Thr Ala  Thr Asp Lys 
    1400                 1405                 1410             


Ile Gly  Arg Ser Val Pro Ala  Pro Gly Lys Gly Ile  Leu Thr Thr 
    1415                 1420                 1425             


Ala Arg  Glu His His Ser Ser  Val Lys Tyr Ala Ser  Pro Asn Leu 
    1430                 1435                 1440             


Asn Met  Lys Tyr Arg Lys Arg  Gln Leu Val Thr Arg  Glu Ala Gln 
    1445                 1450                 1455             


Ile Lys  Asp Trp Val Glu Asn  Glu Leu Glu Ala Leu  Lys Leu Glu 
    1460                 1465                 1470             


Ala Glu  Glu Ile Pro Ser Glu  Asp Gln Asn Glu Phe  Leu Leu Glu 
    1475                 1480                 1485             


Arg Thr  Arg Glu Ile His Asn  Glu Ala Asp Ser Gln  Leu Arg Ala 
    1490                 1495                 1500             


Ala Gln  Gln Gln Trp Gly Asn  Asp Phe Tyr Lys Arg  Asp Pro Arg 
    1505                 1510                 1515             


Ile Ala  Pro Leu Arg Gly Ala  Leu Ala Thr Tyr Gly  Leu Thr Ile 
    1520                 1525                 1530             


Asp Asp  Leu Gly Val Ala Ser  Phe His Gly Thr Ser  Thr Lys Ala 
    1535                 1540                 1545             


Asn Asp  Lys Asn Glu Ser Ala  Thr Ile Asn Glu Met  Met Lys His 
    1550                 1555                 1560             


Leu Gly  Arg Ser Glu Gly Asn  Pro Val Ile Gly Val  Phe Gln Lys 
    1565                 1570                 1575             


Phe Leu  Thr Gly His Pro Lys  Gly Ala Ala Gly Ala  Trp Met Met 
    1580                 1585                 1590             


Asn Gly  Ala Leu Gln Ile Leu  Asn Ser Gly Ile Ile  Pro Gly Asn 
    1595                 1600                 1605             


Arg Asn  Ala Asp Asn Val Asp  Lys Ile Leu Glu Gln  Phe Glu Tyr 
    1610                 1615                 1620             


Val Leu  Tyr Pro Ser Lys Thr  Leu Lys Thr Asp Gly  Val Arg Ala 
    1625                 1630                 1635             


Val Ser  Ile Thr Ser Phe Gly  Phe Gly Gln Lys Gly  Gly Gln Ala 
    1640                 1645                 1650             


Ile Val  Val His Pro Asp Tyr  Leu Tyr Gly Ala Ile  Thr Glu Asp 
    1655                 1660                 1665             


Arg Tyr  Asn Glu Tyr Val Ala  Lys Val Ser Ala Arg  Glu Lys Ser 
    1670                 1675                 1680             


Ala Tyr  Lys Phe Phe His Asn  Gly Met Ile Tyr Asn  Lys Leu Phe 
    1685                 1690                 1695             


Val Ser  Lys Glu His Ala Pro  Tyr Thr Asp Glu Leu  Glu Glu Asp 
    1700                 1705                 1710             


Val Tyr  Leu Asp Pro Leu Ala  Arg Val Ser Lys Asp  Lys Lys Ser 
    1715                 1720                 1725             


Gly Ser  Leu Thr Phe Asn Ser  Lys Asn Ile Gln Ser  Lys Asp Ser 
    1730                 1735                 1740             


Tyr Ile  Asn Ala Asn Thr Ile  Glu Thr Ala Lys Met  Ile Glu Asn 
    1745                 1750                 1755             


Met Thr  Lys Glu Lys Val Ser  Asn Gly Gly Val Gly  Val Asp Val 
    1760                 1765                 1770             


Glu Leu  Ile Thr Ser Ile Asn  Val Glu Asn Asp Thr  Phe Ile Glu 
    1775                 1780                 1785             


Arg Asn  Phe Thr Pro Gln Glu  Ile Glu Tyr Cys Asn  Ala Gln Pro 
    1790                 1795                 1800             


Ser Val  Gln Ser Ser Phe Ala  Gly Thr Trp Ser Ala  Lys Glu Ala 
    1805                 1810                 1815             


Val Phe  Lys Ser Leu Gly Val  Lys Ser Leu Gly Gly  Gly Ala Ala 
    1820                 1825                 1830             


Leu Lys  Asp Ile Glu Ile Val  Arg Val Asn Lys Asn  Ala Pro Ala 
    1835                 1840                 1845             


Val Glu  Leu His Gly Asn Ala  Lys Lys Ala Ala Glu  Glu Ala Gly 
    1850                 1855                 1860             


Val Thr  Asp Val Lys Val Ser  Ile Ser His Asp Asp  Leu Gln Ala 
    1865                 1870                 1875             


Val Ala  Val Ala Val Ser Thr  Lys Lys 
    1880                 1885         


<210>  10
<211>  5553
<212>  DNA
<213>  Yarrowia lipolytica

<400>  10
atgcaccccg aagtcgaaca agaactcgcc cacgtgctcc tgacggagct gctggcctac       60

caatttgcct cgcccgtgcg atggatcgag acccaggacg tgctgttcaa gcagttcaat      120

gtcgagcgag tcgtcgaagt cggcccatcc ccaactctcg ccggcatggc ccagcgaacc      180

cttaagtcca agtacgagtc atacgacgct gctctgtctc tgcagcgaga gatcctgtgt      240

tactccaagg accagaagga catctactac cttgccgatg aggccgatga agcccctgcc      300

cccgctgctg gtggtgatgc ccccgctgct cctgccgctg ccgctcctgc cgccgctgcc      360

gctcctgctg ccgctgccgc cccctctggc cccgttgcca aggttgagga cgcccccgtc      420

aaggcccagg agattctcca cgccctggtc gcccataagc tcaagaagac ccccgagcag      480

gtgcccctgt ccaaggccat caaagacctt gttggtggta agtctaccat ccagaacgag      540

attctcggtg atctcggaaa ggaatttggt gccacccctg agaagcccga ggatactccc      600

cttggcgagc tggctgagtc cttccaggcc tcctttgacg gcaagctcgg taagcagtct      660

tcttctctca ttgcccgact catgtcctcc aagatgcccg gagggttctc tctcacctct      720

gctcgatcct acctcgacag cagatggggc ctggctgctg gccgacagga ctccgttctg      780

cttgttgctc tgatgaacga acccaagaac cgacttggct ctgaagccga ggccaaggcc      840

tacctcgacg agcagaccca gaagtatgct gcttctgccg gtcttaacct gtctgccccc      900

gctggtggtg ccgagggtgg caatggcggt ggcgccgtca ttgactccgc tgcctttgac      960

gctctcacca aggaccagcg atacctggtc cagcagcaac tcgagttgtt tgccaactac     1020

ctgaagcagg atctgcgaca gggctccaag gtggctgctg cccagaagga ggccatggat     1080

attctgcaag ctgaactgga tctttggaac tccgagcacg gcgaggtcta cgctgagggc     1140

atcaagcccg ccttctctgc cctgaaggcc cgtgtctacg actcgtactg gaactgggct     1200

cgacaggact cgctctccat gtactttgac attgttttcg gtcgtctctc caccgttgac     1260

cgagagatta tggctaagtg tatccacctg atgaaccgaa ccaaccacaa cctgatcgac     1320

tacatgcagt accacatgga ccacgtcccc gttcacaagg gagccaccta cgagcttgcc     1380

aagcagctcg gtctgcagct cctcgagaac tgtaaggaga ctctcaccga ggcccccgtc     1440

tacaaggatg tctcttaccc cactggaccc cagaccacca ttgatgtcaa gggtaacatt     1500

gtttacaacg aggtgccccg acccaatgtc cgaaagctcg agcagtatgt ccacgagatg     1560

gcctgtggtg gtgagctgac caaggacccc tcttttgttg gagaaggtgt ccagggcgag     1620

ctcaagaagc tgtactctca gatctctgct cttgccaaga cccagaccgg ctctaccctc     1680

gacatcgagg ctctgtactc cgacctggtc gctaagatct cccaggccga ggacgcgtcc     1740

aagcctgtcg ttgagaacaa ggctgtttct gcctccatca ctcccggcac tctccctttt     1800

ctccacatca agaagaagac cgaacttggt gcctggaatt acgacagcga gaccaccgcc     1860

acctacctcg atggtcttga ggttgctgcc cgtgatggtc tcactttcca gggcaagact     1920

gctctgatca ccggtgctgg tgctggctcc attggtgcct caatcctcca gggtctcatt     1980

tccggaggct gcaaagtcat tgtcacaacc tctcgatact cccgaaaggt gaccgagtac     2040

taccagtccc tctacaccaa gttcggtgct aagggttcca ctctgattgt tgtccccttc     2100

aaccaaggct ccaagaagga cgtggacgag ctggtgtcgt tcatctacaa cgaccccaag     2160

aacggcggtc ttggctggga tctggacttt gttgttccct ttgctgctct gcccgagaac     2220

ggtattgagc tggagcacat tgactcaaag tccgagcttg cccatcgaat catgctcacc     2280

aacctcctgc gtctgcttgg taacgtcaag aagcagaaag tggcccattc ctacgagact     2340

cgacccgccc aggtcatgct gcccctgtcg cccaaccatg gcaacttcgg ctccgatggt     2400

ctgtactccg agtccaagat ctctctcgag actctgttca accggtggca caccgagtcc     2460

tggggctctt atctcaccat tgttggtgtg gtgattggct ggacccgagg taccggtctg     2520

atgagcgcca acaacatcac cgccgagggt ctggagcagc tcggcgtccg aaccttctcc     2580

cagactgaga tggccttttc catcatgggt ctcatgacca aggacattgt gcgactggcc     2640

cagaactccc ccgtgtgggc cgatctcaac ggtggcttcc agtacattcc cgacctcaag     2700

ggagttgttg gaaagatccg acgagacatt gtggagacct ccgagatccg acgggctgtg     2760

gctcaggaga ctgccattga acagaaggtg gtcaacggcc cccacgccga tcttccttac     2820

cagaaggtcg aggtcaagcc ccgagccaac ctcaagtttg acttccccac cctcaaatcc     2880

tacgccgagg tcaaggagct gtctcctgct ggtgatgctc tggagggtct tctggatctc     2940

tcttccgtca ttgttgtcac tggtttcgcc gaggtcggtc cttggggtaa cgcccgaacc     3000

cgatgggaca tggaggccaa cggtgtcttc tcccttgagg gtgccattga gatggcctgg     3060

atcatgggtc tgatcaagca ccacaatggt cccctgcccg gcatgcctca gtactctggc     3120

tggatcgata ccaagaccaa gcagcccgtc gatgaccgag atatcaagac caagtacgag     3180

gactacctgc ttgagcacgc cggtatccga ctcattgagc ctgagctgtt ccacggctac     3240

aaccccaaga agaagacctt cctccaggag gttattgtgg agcacgatct cgagcccttt     3300

gaggcctcca aggagtctgc tgagcaattt gctctcgagc agggcgcgaa cgttgagatc     3360

ttcgccgtcc ccgagtccga ccagtggact gtgcgacttc tcaagggcgc caagctcctc     3420

attcccaagg ccctcaagtt tgaccgactt gtggccggcc agattcccac tggatgggat     3480

gcccgacgat acggtattcc cgaggacatt tgtgaccagg ttgaccccat cactctgtac     3540

gctcttgtct ccactgttga ggctctgttg gcctccggta ttaccgaccc ctacgagttc     3600

tacaagtacg tccacgtgtc cgaggtcggt aactgttccg gttccggtat gggtggtatc     3660

accgccctgc gaggcatgtt caaggaccgg ttcatggaca agcctgttca gaacgatatt     3720

ctccaggagt ccttcatcaa caccatgtct gcctgggtca acatgttgct gctctcctct     3780

tccggtccca tcaagacccc cgttggagct tgtgccactg ctgtcgagtc tgtggacatt     3840

ggttgcgaaa ccattctgtc cggcaaggcc agaatctgtc tggtcggtgg ttacgatgat     3900

ttccaggagg agtcttctca ggagtttgca aacatgaacg caacatccaa cgctgagacc     3960

gagatcactc acggccgaac tccggccgag atgtctcgac ccatcacttc cacacgagcc     4020

ggtttcatgg aggctcaggg tgctggaacc caggtgctga tggccgccga cctcgccatc     4080

gccatgggtg tgcccatcta ctgtatcgtt ggttacgtca acactgccac cgacaagatt     4140

ggccgatctg tgcctgctcc cggtaagggt atcctgacca ctgctcgaga gcaccagact     4200

ctcaaacacg ccaaccctct cctcaacatc aagtaccgaa agcgacagct cgattctcga     4260

ctccgagaca ttaagcgatg ggctgagggc gaaatggagg ctattgacat tgagcttgac     4320

gacgtgtctg acgccgacaa ggagtccttc atccaggagc gatctgccca catccagtct     4380

cagtccgatc gaatgatccg agaggctaag aactcttggg gtaacgcctt tttcaagcag     4440

gacgcccgaa tctcccccat ccgaggagcg ctggcaacct acggtctcac cattgatgac     4500

atctccgtcg cttctttcca tggtacatcc accaaggcca acgagaagaa cgagaccacc     4560

accgtcaacg ccatgctgga gcatctcggc agaacccggg gtaaccctgt ctacggtatc     4620

ttccagaagt accttactgg tcaccccaag ggagctgctg gtgcctggat gctcaacgga     4680

gccatccaat gcctcaactc tggtatcatc cctggtaacc gaaacgccga taacgtggat     4740

gcctactttg agcagtgcca gcacgtggtg ttcccctcgc gatctctgca gaccgatggc     4800

ctcaaggctg cttccgtgac ctcctttggt ttcggtcaga agggtgccca ggccattgtc     4860

atccaccccg actacctgta cgctgccctg acaccctccg agtactccga gtacaccacc     4920

cgagtcgccc agcgatacaa gaaggcttac cgatactacc acaacgccat tgccgaggag     4980

tccatgttcc aggccaagga caaggctccc tactctgctg agctggagca ggaggtctac     5040

ctggatcctc ttgtgcgagt ccaccagaac gaggacaccg agcagtactc cttcaacgcc     5100

aaggacctcg ctgcctccgc ctttgtcaag aactcccaca aggacaccgc caaggtgctt     5160

gccaacctca cctcccaggt gtccggttct ggtaagaacg ttggtgtcga cgttgaggcc     5220

atctccgcca tcaacattga taacgacacc ttccttgacc gaaacttcac cgccaacgag     5280

caggcctact gcttcaaggc cccctccccc cagtcttctt tcgctggcac ttggtctgcc     5340

aaggaggctg ttttcaagtc tctgggcgtc aagtcccagg gcggaggagc tgagctcaag     5400

tccattgaga tcactcgaga tggcaacgga gctcccgtcg tggttcttca cggagctgcc     5460

aaggacgctg ctgcttctaa gggtatctcc accgtcaagg tgtccatttc ccatgacgac     5520

tctcaggccg tggctgttgc tgttgccgag tag                                  5553


<210>  11
<211>  1860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  alpha FAS consensus sequence


<220>
<221>  Variant
<222>  (94)..(94)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (96)..(96)
<223>  Replace = Ser, Glu or Thr

<220>
<221>  Variant
<222>  (97)..(97)
<223>  Replace = Ala or Glu

<220>
<221>  Variant
<222>  (101)..(101)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (102)..(102)
<223>  Replace = Pro

<220>
<221>  Variant
<222>  (103)..(103)
<223>  Replace =Pro or Ser

<220>
<221>  Variant
<222>  (104)..(104)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (105)..(105)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (106)..(106)
<223>  Replace = Ser or nothi

<220>
<221>  Variant
<222>  (106)..(106)
<223>  Replace = Ser or nothing

<220>
<221>  Variant
<222>  (107)..(107)
<223>  Replace = Ser, Thr or nothing

<220>
<221>  Variant
<222>  (108)..(108)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (109)..(109)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (110)..(110)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (111)..(111)
<223>  Replace = Pro

<220>
<221>  Variant
<222>  (112)..(112)
<223>  Replace = Ala or Gly

<220>
<221>  Variant
<222>  (113)..(113)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (114)..(114)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (115)..(115)
<223>  Replace = Ser, Asp or nothing

<220>
<221>  Variant
<222>  (116)..(116)
<223>  Replace = Pro or Ser

<220>
<221>  Variant
<222>  (117)..(117)
<223>  Replace = Pro, Ser or Thr

<220>
<221>  Variant
<222>  (118)..(118)
<223>  Replace = Ala or Val

<220>
<221>  Variant
<222>  (119)..(119)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (121)..(121)
<223>  Replace = Ala or Thr

<220>
<221>  Variant
<222>  (122)..(122)
<223>  Replace = Pro, Thr or His

<220>
<221>  Variant
<222>  (123)..(123)
<223>  Replace = Pro

<220>
<221>  Variant
<222>  (124)..(124)
<223>  Replace = Val or nothing

<220>
<221>  Variant
<222>  (125)..(125)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (127)..(127)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (130)..(130)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (131)..(131)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (132)..(132)
<223>  Replace = Val or nothing

<220>
<221>  Variant
<222>  (133)..(133)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (141)..(141)
<223>  Replace = Val

<220>
<221>  Variant
<222>  (145)..(145)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (147)..(147)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (152)..(152)
<223>  Replace = Lys or Val

<220>
<221>  Variant
<222>  (166)..(166)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (168)..(168)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (170)..(170)
<223>  Replace = Ile

<220>
<221>  Variant
<222>  (172)..(172)
<223>  Replace = Met

<220>
<221>  Variant
<222>  (211)..(211)
<223>  Replace = Ala or Asp

<220>
<221>  Variant
<222>  (249)..(249)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (252)..(252)
<223>  Replace = Thr or Gly

<220>
<221>  Variant
<222>  (255)..(255)
<223>  Replace = Asp

<220>
<221>  Variant
<222>  (256)..(256)
<223>  Replace = Asp or Thr

<220>
<221>  Variant
<222>  (261)..(261)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (262)..(262)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (271)..(271)
<223>  Replace = Met

<220>
<221>  Variant
<222>  (281)..(281)
<223>  Replace = Phe

<220>
<221>  Variant
<222>  (282)..(282)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (285)..(285)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (286)..(286)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (301)..(301)
<223>  Replace = Gly

<220>
<221>  Variant
<222>  (304)..(304)
<223>  Replace = Leu

<220>
<221>  Variant
<222>  (307)..(307)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (308)..(308)
<223>  Replace = Ala or Thr

<220>
<221>  Variant
<222>  (310)..(310)
<223>  Replace = Ala or Thr

<220>
<221>  Variant
<222>  (311)..(311)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (312)..(312)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (313)..(313)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (317)..(317)
<223>  Replace = Asn

<220>
<221>  Variant
<222>  (319)..(319)
<223>  Replace = Gly

<220>
<221>  Variant
<222>  (356)..(356)
<223>  Replace = Ser

<220>
<221>  Variant
<222>  (358)..(358)
<223>  Replace = Phe

<220>
<221>  Variant
<222>  (370)..(370)
<223>  Replace = Ile

<220>
<221>  Variant
<222>  (380)..(380)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (385)..(385)
<223>  Replace = Ile

<220>
<221>  Variant
<222>  (388)..(388)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (396)..(396)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (446)..(446)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (461)..(461)
<223>  Replace = His

<220>
<221>  Variant
<222>  (486)..(486)
<223>  Replace = Val

<220>
<221>  Variant
<222>  (487)..(487)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (527)..(527)
<223>  Replace = Ala or Asn

<220>
<221>  Variant
<222>  (531)..(531)
<223>  Replace = Ser, Cys or Val

<220>
<221>  Variant
<222>  (536)..(536)
<223>  Replace = Arg

<220>
<221>  Variant
<222>  (540)..(540)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (541)..(541)
<223>  Replace = Tyr

<220>
<221>  Variant
<222>  (542)..(542)
<223>  Replace = Ala or Val

<220>
<221>  Variant
<222>  (544)..(544)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (554)..(554)
<223>  Replace = Tyr

<220>
<221>  Variant
<222>  (555)..(555)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (559)..(559)
<223>  Replace = Gln

<220>
<221>  Variant
<222>  (560)..(560)
<223>  Replace = Leu

<220>
<221>  Variant
<222>  (563)..(563)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (564)..(564)
<223>  Replace = Gln

<220>
<221>  Variant
<222>  (565)..(565)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (567)..(567)
<223>  Replace = Ser

<220>
<221>  Variant
<222>  (568)..(568)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (570)..(570)
<223>  Replace = Lys or Asn

<220>
<221>  Variant
<222>  (573)..(573)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (574)..(574)
<223>  Replace = Leu

<220>
<221>  Variant
<222>  (576)..(576)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (580)..(580)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (581)..(581)
<223>  Replace = Arg or Glu

<220>
<221>  Variant
<222>  (583)..(583)
<223>  Replace = Arg or Gly

<220>
<221>  Variant
<222>  (584)..(584)
<223>  Replace = Lys

<220>
<221>  Variant
<222>  (585)..(585)
<223>  Replace = Ala or Val

<220>
<221>  Variant
<222>  (587)..(587)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (588)..(588)
<223>  Replace = Asp or Val

<220>
<221>  Variant
<222>  (589)..(589)
<223>  Replace = Thr, Asn or nothing

<220>
<221>  Variant
<222>  (590)..(590)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (591)..(591)
<223>  Replace = Ser

<220>
<221>  Variant
<222>  (592)..(592)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (593)..(593)
<223>  Replace = Ala, Lys or Asp

<220>
<221>  Variant
<222>  (594)..(594)
<223>  Replace = Ser

<220>
<221>  Variant
<222>  (595)..(595)
<223>  Replace = Ala, Lys, Glu or Asp

<220>
<221>  Variant
<222>  (596)..(596)
<223>  Replace = Asn

<220>
<221>  Variant
<222>  (598)..(598)
<223>  Replace = Ala or Thr

<220>
<221>  Variant
<222>  (601)..(601)
<223>  Replace = Ala or Asp

<220>
<221>  Variant
<222>  (602)..(602)
<223>  Replace = Ala, Gln or Val

<220>
<221>  Variant
<222>  (603)..(603)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (604)..(604)
<223>  Replace = Pro or Val

<220>
<221>  Variant
<222>  (615)..(615)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (626)..(626)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (627)..(627)
<223>  Replace = Gln, Pro or Lys

<220>
<221>  Variant
<222>  (630)..(630)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (631)..(631)
<223>  Replace = Met

<220>
<221>  Variant
<222>  (647)..(647)
<223>  Replace = Gln, Ala or Lys

<220>
<221>  Variant
<222>  (669)..(669)
<223>  Replace = Met

<220>
<221>  Variant
<222>  (693)..(693)
<223>  Replace = Gly

<220>
<221>  Variant
<222>  (696)..(696)
<223>  Replace = Arg

<220>
<221>  Variant
<222>  (697)..(697)
<223>  Replace = Tyr

<220>
<221>  Variant
<222>  (716)..(716)
<223>  Replace = Arg

<220>
<221>  Variant
<222>  (724)..(724)
<223>  Replace = Tyr

<220>
<221>  Variant
<222>  (727)..(727)
<223>  Replace = Asp

<220>
<221>  Variant
<222>  (728)..(728)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (731)..(731)
<223>  Replace = Val

<220>
<221>  Variant
<222>  (742)..(742)
<223>  Replace = Ile

<220>
<221>  Variant
<222>  (755)..(755)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (787)..(787)
<223>  Replace = His

<220>
<221>  Variant
<222>  (796)..(796)
<223>  Replace = Met

<220>
<221>  Variant
<222>  (799)..(799)
<223>  Replace = Met

<220>
<221>  Variant
<222>  (805)..(805)
<223>  Replace = Ile

<220>
<221>  Variant
<222>  (828)..(828)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (863)..(863)
<223>  Replace = Lys

<220>
<221>  Variant
<222>  (884)..(884)
<223>  Replace = Lys

<220>
<221>  Variant
<222>  (893)..(893)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (911)..(911)
<223>  Replace = Asp

<220>
<221>  Variant
<222>  (914)..(914)
<223>  Replace = Gly

<220>
<221>  Variant
<222>  (915)..(915)
<223>  Replace = Asn

<220>
<221>  Variant
<222>  (919)..(919)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (955)..(955)
<223>  Replace = Ile

<220>
<221>  Variant
<222>  (971)..(971)
<223>  Replace = His

<220>
<221>  Variant
<222>  (972)..(972)
<223>  Replace = Gln or Ser

<220>
<221>  Variant
<222>  (974)..(974)
<223>  Replace = Ile

<220>
<221>  Variant
<222>  (977)..(977)
<223>  Replace = Phe

<220>
<221>  Variant
<222>  (983)..(983)
<223>  Replace = Ala or Asp

<220>
<221>  Variant
<222>  (1039)..(1039)
<223>  Replace = Asn

<220>
<221>  Variant
<222>  (1043)..(1043)
<223>  Replace = Pro

<220>
<221>  Variant
<222>  (1045)..(1045)
<223>  Replace = Ile, Lys, Leu or nothing

<220>
<221>  Variant
<222>  (1046)..(1046)
<223>  Replace = Gln or Lys

<220>
<221>  Variant
<222>  (1047)..(1047)
<223>  Replace = Lys

<220>
<221>  Variant
<222>  (1054)..(1054)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (1056)..(1056)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (1058)..(1058)
<223>  Replace = Lys

<220>
<221>  Variant
<222>  (1067)..(1067)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (1068)..(1068)
<223>  Replace = Asn

<220>
<221>  Variant
<222>  (1071)..(1071)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (1075)..(1075)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (1077)..(1077)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1084)..(1084)
<223>  Replace = Ser

<220>
<221>  Variant
<222>  (1088)..(1088)
<223>  Replace = Gln, Ser or Asn

<220>
<221>  Variant
<222>  (1091)..(1091)
<223>  Replace = Asp

<220>
<221>  Variant
<222>  (1147)..(1147)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1191)..(1191)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1270)..(1270)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1332)..(1332)
<223>  Replace = Met or Leu

<220>
<221>  Variant
<222>  (1333)..(1333)
<223>  Replace = Ala or Thr

<220>
<221>  Variant
<222>  (1350)..(1350)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1362)..(1362)
<223>  Replace = Ile

<220>
<221>  Variant
<222>  (1363)..(1363)
<223>  Replace = Leu

<220>
<221>  Variant
<222>  (1371)..(1371)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (1378)..(1378)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1414)..(1414)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1419)..(1419)
<223>  Replace = Asn

<220>
<221>  Variant
<222>  (1420)..(1420)
<223>  Replace = Ile

<220>
<221>  Variant
<222>  (1421)..(1421)
<223>  Replace = Arg

<220>
<221>  Variant
<222>  (1428)..(1428)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (1429)..(1429)
<223>  Replace = Ala or Thr

<220>
<221>  Variant
<222>  (1432)..(1432)
<223>  Replace = Gln

<220>
<221>  Variant
<222>  (1438)..(1438)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1440)..(1440)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1446)..(1446)
<223>  Replace = Glu or Asn

<220>
<221>  Variant
<222>  (1447)..(1447)
<223>  Replace = Ala or Met

<220>
<221>  Variant
<222>  (1450)..(1450)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (1451)..(1451)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (1452)..(1452)
<223>  Replace = Ile

<220>
<221>  Variant
<222>  (1453)..(1453)
<223>  Replace = Ala or Asp

<220>
<221>  Variant
<222>  (1454)..(1454)
<223>  Replace = Ala or Glu

<220>
<221>  Variant
<222>  (1455)..(1455)
<223>  Replace = Glu or Asn

<220>
<221>  Variant
<222>  (1456)..(1456)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (1457)..(1457)
<223>  Replace = Arg

<220>
<221>  Variant
<222>  (1458)..(1458)
<223>  Replace = Lys

<220>
<221>  Variant
<222>  (1462)..(1462)
<223>  Replace = Gln

<220>
<221>  Variant
<222>  (1469)..(1469)
<223>  Replace = Ala, His or Thr

<220>
<221>  Variant
<222>  (1472)..(1472)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (1473)..(1473)
<223>  Replace = Glu

<220>
<221>  Variant
<222>  (1476)..(1476)
<223>  Replace = Met, Thr or Val

<220>
<221>  Variant
<222>  (1486)..(1486)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1488)..(1488)
<223>  Replace = Tyr

<220>
<221>  Variant
<222>  (1489)..(1489)
<223>  Replace = Arg

<220>
<221>  Variant
<222>  (1492)..(1492)
<223>  Replace = Pro

<220>
<221>  Variant
<222>  (1591)..(1591)
<223>  Replace = Val

<220>
<221>  Variant
<222>  (1597)..(1597)
<223>  Replace = His

<220>
<221>  Variant
<222>  (1606)..(1606)
<223>  Replace = Met

<220>
<221>  Variant
<222>  (1641)..(1641)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (1642)..(1642)
<223>  Replace = Pro or Ser

<220>
<221>  Variant
<222>  (1646)..(1646)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1647)..(1647)
<223>  Replace = Asp or Gly

<220>
<221>  Variant
<222>  (1649)..(1649)
<223>  Replace = Ala or Val

<220>
<221>  Variant
<222>  (1650)..(1650)
<223>  Replace = Ser or Asn

<220>
<221>  Variant
<222>  (1653)..(1653)
<223>  Replace = Ala or Asp

<220>
<221>  Variant
<222>  (1665)..(1665)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (1682)..(1682)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1687)..(1687)
<223>  Replace = Lys

<220>
<221>  Variant
<222>  (1700)..(1700)
<223>  Replace = Asn

<220>
<221>  Variant
<222>  (1701)..(1701)
<223>  Replace = Lys or Asp

<220>
<221>  Variant
<222>  (1708)..(1708)
<223>  Replace = Tyr

<220>
<221>  Variant
<222>  (1709)..(1709)
<223>  Replace = Ser or Asp

<220>
<221>  Variant
<222>  (1715)..(1715)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1717)..(1717)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1721)..(1721)
<223>  Replace = Ser or Asp

<220>
<221>  Variant
<222>  (1722)..(1722)
<223>  Replace = Asn

<220>
<221>  Variant
<222>  (1732)..(1732)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (1738)..(1738)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1739)..(1739)
<223>  Replace = Gly

<220>
<221>  Variant
<222>  (1740)..(1740)
<223>  Replace = Gly

<220>
<221>  Variant
<222>  (1741)..(1741)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (1742)..(1742)
<223>  Replace = nothing

<220>
<221>  Variant
<222>  (1768)..(1768)
<223>  Replace = Glu or Thr

<220>
<221>  Variant
<222>  (1769)..(1769)
<223>  Replace = Glu or Thr

<220>
<221>  Variant
<222>  (1776)..(1776)
<223>  Replace = Arg

<220>
<221>  Variant
<222>  (1780)..(1780)
<223>  Replace = Pro

<220>
<221>  Variant
<222>  (1810)..(1810)
<223>  Replace = Arg

<220>
<221>  Variant
<222>  (1815)..(1815)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (1818)..(1818)
<223>  Replace = Ala or Asp

<220>
<221>  Variant
<222>  (1820)..(1820)
<223>  Replace = Lys

<220>
<221>  Variant
<222>  (1823)..(1823)
<223>  Replace = Gln

<220>
<221>  Variant
<222>  (1829)..(1829)
<223>  Replace = Asp or Val

<220>
<221>  Variant
<222>  (1832)..(1832)
<223>  Replace = Ala or Glu

<220>
<221>  Variant
<222>  (1835)..(1835)
<223>  Replace = Ser or Glu

<220>
<221>  Variant
<222>  (1836)..(1836)
<223>  Replace = Ala

<220>
<221>  Variant
<222>  (1837)..(1837)
<223>  Replace = Arg

<220>
<221>  Variant
<222>  (1839)..(1839)
<223>  Replace = Leu

<220>
<221>  Variant
<222>  (1840)..(1840)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (1841)..(1841)
<223>  Replace = Thr

<220>
<221>  Variant
<222>  (1851)..(1851)
<223>  Replace = Thr

<400>  11

Met His Pro Glu Val Glu Gln Glu Leu Ala His Val Leu Leu Thr Glu 
1               5                   10                  15      


Leu Leu Ala Tyr Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln 
            20                  25                  30          


Asp Val Leu Phe Lys Gln Phe Asn Val Glu Arg Val Val Glu Val Gly 
        35                  40                  45              


Pro Ser Pro Thr Leu Ala Gly Met Ala Gln Arg Thr Leu Lys Ser Lys 
    50                  55                  60                  


Tyr Glu Ser Tyr Asp Ala Ala Leu Ser Leu Gln Arg Glu Ile Leu Cys 
65                  70                  75                  80  


Tyr Ser Lys Asp Gln Lys Asp Ile Tyr Tyr Leu Ala Asp Glu Glu Ala 
                85                  90                  95      


Asp Glu Ala Pro Ala Ala Ala Ala Ser Gly Gly Asp Ala Ser Ala Ser 
            100                 105                 110         


Ala Asp Ala Ala Ala Pro Ser Ala Ser Ala Ala Ala Ser Ser Ser Ala 
        115                 120                 125             


Pro Ala Ala Ala Ala Ala Ala Ala Ser Ser Gly Pro Ala Ala Lys Val 
    130                 135                 140                 


Asp Asp Ser Pro Val Lys Ala Gln Glu Ile Leu His Ala Leu Val Ala 
145                 150                 155                 160 


His Lys Leu Lys Lys Ser Pro Asp Gln Val Pro Leu Ser Lys Ala Ile 
                165                 170                 175     


Lys Asp Leu Val Gly Gly Lys Ser Thr Ile Gln Asn Glu Ile Leu Gly 
            180                 185                 190         


Asp Leu Gly Lys Glu Phe Gly Ala Thr Pro Glu Lys Pro Glu Asp Thr 
        195                 200                 205             


Pro Leu Gly Glu Leu Ala Glu Ser Phe Gln Ala Ser Phe Asp Gly Lys 
    210                 215                 220                 


Leu Gly Lys Gln Ser Ser Ser Leu Ile Ala Arg Leu Met Ser Ser Lys 
225                 230                 235                 240 


Met Pro Gly Gly Phe Ser Leu Thr Ser Ala Arg Ser Tyr Leu Gly Ser 
                245                 250                 255     


Arg Trp Gly Leu Gly Ser Gly Arg Gln Asp Ser Val Leu Leu Val Ala 
            260                 265                 270         


Leu Met Asn Glu Pro Lys Asn Arg Leu Gly Ser Glu Gly Asp Ala Lys 
        275                 280                 285             


Ala Tyr Leu Asp Glu Gln Thr Gln Lys Tyr Ala Ala Ser Ala Gly Ile 
    290                 295                 300                 


Asn Leu Ser Ser Pro Ser Gly Gly Ser Glu Gly Gly Ser Gly Ser Gly 
305                 310                 315                 320 


Ala Val Ile Asp Ser Ala Ala Phe Asp Ala Leu Thr Lys Asp Gln Arg 
                325                 330                 335     


Tyr Leu Val Gln Gln Gln Leu Glu Leu Phe Ala Asn Tyr Leu Lys Gln 
            340                 345                 350         


Asp Leu Arg Gln Gly Ser Lys Val Ala Ala Ala Gln Lys Glu Ala Met 
        355                 360                 365             


Asp Val Leu Gln Ala Glu Leu Asp Leu Trp Asn Ser Glu His Gly Glu 
    370                 375                 380                 


Val Tyr Ala Asp Gly Ile Lys Pro Ala Phe Ser Ser Leu Lys Ala Arg 
385                 390                 395                 400 


Val Tyr Asp Ser Tyr Trp Asn Trp Ala Arg Gln Asp Ser Leu Ser Met 
                405                 410                 415     


Tyr Phe Asp Ile Val Phe Gly Arg Leu Ser Thr Val Asp Arg Glu Ile 
            420                 425                 430         


Met Ala Lys Cys Ile His Leu Met Asn Arg Thr Asn His Asn Leu Ile 
        435                 440                 445             


Asp Tyr Met Gln Tyr His Met Asp His Val Pro Val Gln Lys Gly Ala 
    450                 455                 460                 


Thr Tyr Glu Leu Ala Lys Gln Leu Gly Leu Gln Leu Leu Glu Asn Cys 
465                 470                 475                 480 


Lys Glu Thr Leu Thr Glu Ser Pro Val Tyr Lys Asp Val Ser Tyr Pro 
                485                 490                 495     


Thr Gly Pro Gln Thr Thr Ile Asp Val Lys Gly Asn Ile Val Tyr Asn 
            500                 505                 510         


Glu Val Pro Arg Pro Asn Val Arg Lys Leu Glu Gln Tyr Val His Glu 
        515                 520                 525             


Met Ala Ala Gly Gly Glu Leu Thr Lys Asp Pro Ser Phe Thr Gly Asp 
    530                 535                 540                 


Gly Val Gln Gly Glu Leu Lys Lys Leu Phe Ser Gln Ile Ser Ala Ile 
545                 550                 555                 560 


Ala Lys Thr Glu Ala Gly Pro Ser Leu Asp Ile Glu Ala Ile Tyr Ser 
                565                 570                 575     


Asp Leu Val Ser Lys Ile Ser Gln Thr Glu Asp Ala Ser Lys Pro Asp 
            580                 585                 590         


Val Val Gln Ser Lys Ser Val Ser Ser Ser Ile Thr Pro Gly Thr Leu 
        595                 600                 605             


Pro Phe Leu His Ile Lys Lys Lys Thr Glu Leu Gly Ala Trp Asn Tyr 
    610                 615                 620                 


Asp Ser Glu Thr Thr Ser Thr Tyr Leu Asp Gly Leu Glu Val Ala Ala 
625                 630                 635                 640 


Arg Asp Gly Leu Thr Phe Glu Gly Lys Thr Ala Leu Ile Thr Gly Ala 
                645                 650                 655     


Gly Ala Gly Ser Ile Gly Ala Ser Ile Leu Gln Gly Leu Ile Ser Gly 
            660                 665                 670         


Gly Cys Lys Val Ile Val Thr Thr Ser Arg Tyr Ser Arg Lys Val Thr 
        675                 680                 685             


Glu Tyr Tyr Gln Ser Leu Tyr Thr Lys Phe Gly Ala Lys Gly Ser Thr 
    690                 695                 700                 


Leu Ile Val Val Pro Phe Asn Gln Gly Ser Lys Lys Asp Val Asp Glu 
705                 710                 715                 720 


Leu Val Ser Phe Ile Tyr Asn Asp Pro Lys Asn Gly Gly Leu Gly Trp 
                725                 730                 735     


Asp Leu Asp Phe Val Val Pro Phe Ala Ala Leu Pro Glu Asn Gly Ile 
            740                 745                 750         


Glu Leu Asp His Ile Asp Ser Lys Ser Glu Leu Ala His Arg Ile Met 
        755                 760                 765             


Leu Thr Asn Leu Leu Arg Leu Leu Gly Asn Val Lys Lys Gln Lys Val 
    770                 775                 780                 


Ala His Ser Tyr Glu Thr Arg Pro Ala Gln Val Leu Leu Pro Leu Ser 
785                 790                 795                 800 


Pro Asn His Gly Asn Phe Gly Ser Asp Gly Leu Tyr Ser Glu Ser Lys 
                805                 810                 815     


Ile Ser Leu Glu Thr Leu Phe Asn Arg Trp His Ser Glu Ser Trp Gly 
            820                 825                 830         


Ser Tyr Leu Thr Ile Val Gly Val Val Ile Gly Trp Thr Arg Gly Thr 
        835                 840                 845             


Gly Leu Met Ser Ala Asn Asn Ile Thr Ala Glu Gly Leu Glu Gln Leu 
    850                 855                 860                 


Gly Val Arg Thr Phe Ser Gln Thr Glu Met Ala Phe Ser Ile Met Gly 
865                 870                 875                 880 


Leu Met Thr Gln Asp Ile Val Arg Leu Ala Gln Asn Ser Pro Val Trp 
                885                 890                 895     


Ala Asp Leu Asn Gly Gly Phe Gln Tyr Ile Pro Asp Leu Lys Gly Val 
            900                 905                 910         


Val Ser Lys Ile Arg Arg Asp Ile Val Glu Thr Ser Glu Ile Arg Arg 
        915                 920                 925             


Ala Val Ala Gln Glu Thr Ala Ile Glu Gln Lys Val Val Asn Gly Pro 
    930                 935                 940                 


His Ala Asp Leu Pro Tyr Gln Lys Val Glu Val Lys Pro Arg Ala Asn 
945                 950                 955                 960 


Leu Lys Phe Asp Phe Pro Thr Leu Lys Ser Tyr Ala Glu Val Lys Glu 
                965                 970                 975     


Leu Ser Pro Ala Gly Asp Ser Leu Glu Gly Leu Leu Asp Leu Ser Ser 
            980                 985                 990         


Val Ile Val Val Thr Gly Phe Ala  Glu Val Gly Pro Trp  Gly Asn Ala 
        995                 1000                 1005             


Arg Thr  Arg Trp Asp Met Glu  Ala Asn Gly Val Phe  Ser Leu Glu 
    1010                 1015                 1020             


Gly Ala  Ile Glu Met Ala Trp  Ile Met Gly Leu Ile  Lys His His 
    1025                 1030                 1035             


Ser Gly  Pro Leu Ala Gly Met  Pro Gln Tyr Ser Gly  Trp Ile Asp 
    1040                 1045                 1050             


Ala Lys  Ser Lys Gln Pro Val  Asp Asp Arg Asp Ile  Lys Asn Lys 
    1055                 1060                 1065             


Tyr Glu  Asp Tyr Leu Leu Asp  His Ser Gly Ile Arg  Leu Ile Glu 
    1070                 1075                 1080             


Pro Glu  Leu Phe His Gly Tyr  Asn Pro Lys Lys Lys  Thr Phe Leu 
    1085                 1090                 1095             


Gln Glu  Val Ile Val Glu His  Asp Leu Glu Pro Phe  Glu Ala Ser 
    1100                 1105                 1110             


Lys Glu  Ser Ala Glu Gln Phe  Ala Leu Glu Gln Gly  Ala Asn Val 
    1115                 1120                 1125             


Glu Ile  Phe Ala Val Pro Glu  Ser Asp Gln Trp Thr  Val Arg Leu 
    1130                 1135                 1140             


Leu Lys  Gly Ser Lys Leu Leu  Ile Pro Lys Ala Leu  Lys Phe Asp 
    1145                 1150                 1155             


Arg Leu  Val Ala Gly Gln Ile  Pro Thr Gly Trp Asp  Ala Arg Arg 
    1160                 1165                 1170             


Tyr Gly  Ile Pro Glu Asp Ile  Cys Asp Gln Val Asp  Pro Ile Thr 
    1175                 1180                 1185             


Leu Tyr  Cys Leu Val Ser Thr  Val Glu Ala Leu Leu  Ala Ser Gly 
    1190                 1195                 1200             


Ile Thr  Asp Pro Tyr Glu Phe  Tyr Lys Tyr Val His  Val Ser Glu 
    1205                 1210                 1215             


Val Gly  Asn Cys Ser Gly Ser  Gly Met Gly Gly Ile  Thr Ala Leu 
    1220                 1225                 1230             


Arg Gly  Met Phe Lys Asp Arg  Phe Met Asp Lys Pro  Val Gln Asn 
    1235                 1240                 1245             


Asp Ile  Leu Gln Glu Ser Phe  Ile Asn Thr Met Ser  Ala Trp Val 
    1250                 1255                 1260             


Asn Met  Leu Leu Leu Ser Ser  Ser Gly Pro Ile Lys  Thr Pro Val 
    1265                 1270                 1275             


Gly Ala  Cys Ala Thr Ala Val  Glu Ser Val Asp Ile  Gly Cys Glu 
    1280                 1285                 1290             


Thr Ile  Leu Ser Gly Lys Ala  Arg Ile Cys Leu Val  Gly Gly Tyr 
    1295                 1300                 1305             


Asp Asp  Phe Gln Glu Glu Ser  Ser Gln Glu Phe Ala  Asn Met Asn 
    1310                 1315                 1320             


Ala Thr  Ser Asn Ala Glu Thr  Glu Ile Ser His Gly  Arg Thr Pro 
    1325                 1330                 1335             


Ala Glu  Met Ser Arg Pro Ile  Thr Ser Thr Arg Ser  Gly Phe Met 
    1340                 1345                 1350             


Glu Ala  Gln Gly Ala Gly Thr  Gln Val Ile Met Ala  Ala Asp Leu 
    1355                 1360                 1365             


Ala Ile  Ala Met Gly Val Pro  Ile Tyr Cys Ile Val  Gly Tyr Val 
    1370                 1375                 1380             


Asn Thr  Ala Thr Asp Lys Ile  Gly Arg Ser Val Pro  Ala Pro Gly 
    1385                 1390                 1395             


Lys Gly  Ile Leu Thr Thr Ala  Arg Glu His Gln Thr  Leu Lys His 
    1400                 1405                 1410             


Ser Asn  Pro Leu Leu Ser Val  Lys Tyr Arg Lys Arg  Gln Leu Asp 
    1415                 1420                 1425             


Ser Arg  Leu Arg Asp Ile Lys  Arg Trp Ser Glu Gly  Glu Met Glu 
    1430                 1435                 1440             


Ala Ile  Asp Ile Glu Leu Asp  Asp Val Ser Asp Ala  Asp Lys Glu 
    1445                 1450                 1455             


Ser Phe  Ile Glu Glu Arg Ser  Ala His Ile Gln Ser  Gln Ser Asp 
    1460                 1465                 1470             


Arg Met  Ile Arg Glu Ala Lys  Asn Ser Trp Gly Asn  Ser Phe Phe 
    1475                 1480                 1485             


Lys Gln  Asp Ala Arg Ile Ser  Pro Ile Arg Gly Ala  Leu Ala Thr 
    1490                 1495                 1500             


Tyr Gly  Leu Thr Ile Asp Asp  Ile Ser Val Ala Ser  Phe His Gly 
    1505                 1510                 1515             


Thr Ser  Thr Lys Ala Asn Glu  Lys Asn Glu Thr Thr  Thr Val Asn 
    1520                 1525                 1530             


Ala Met  Leu Glu His Leu Gly  Arg Thr Arg Gly Asn  Pro Val Tyr 
    1535                 1540                 1545             


Gly Ile  Phe Gln Lys Tyr Leu  Thr Gly His Pro Lys  Gly Ala Ala 
    1550                 1555                 1560             


Gly Ala  Trp Met Leu Asn Gly  Ala Ile Gln Cys Leu  Asn Ser Gly 
    1565                 1570                 1575             


Ile Ile  Pro Gly Asn Arg Asn  Ala Asp Asn Val Asp  Ala Tyr Phe 
    1580                 1585                 1590             


Glu Gln  Cys Gln His Val Val  Phe Pro Ser Arg Ser  Leu Gln Thr 
    1595                 1600                 1605             


Asp Gly  Leu Lys Ala Ala Ser  Val Thr Ser Phe Gly  Phe Gly Gln 
    1610                 1615                 1620             


Lys Gly  Ala Gln Ala Ile Val  Ile His Pro Asp Tyr  Leu Tyr Ala 
    1625                 1630                 1635             


Ala Leu  Ser Ala Ser Glu Tyr  Ser Glu Tyr Thr Thr  Arg Val Gly 
    1640                 1645                 1650             


Gln Arg  Tyr Lys Lys Ala Tyr  Arg Tyr Tyr His Asn  Ala Ile Ala 
    1655                 1660                 1665             


Glu Glu  Ser Met Phe Gln Ala  Lys Asp Lys Ala Pro  Tyr Ser Ala 
    1670                 1675                 1680             


Glu Leu  Glu Gln Glu Val Tyr  Leu Asp Pro Leu Val  Arg Val His 
    1685                 1690                 1695             


Gln Ser  Glu Asp Thr Glu Gln  Tyr Ser Phe Asn Ala  Lys Asp Leu 
    1700                 1705                 1710             


Ala Ser  Ser Ser Phe Val Lys  Asn Ser His Lys Asp  Thr Ala Lys 
    1715                 1720                 1725             


Val Leu  Ala Asn Leu Thr Ser  Gln Val Ser Ser Ser  Gly Lys Asn 
    1730                 1735                 1740             


Val Gly  Val Asp Val Glu Ala  Ile Ser Ala Ile Asn  Ile Asp Asn 
    1745                 1750                 1755             


Asp Thr  Phe Leu Asp Arg Asn  Phe Thr Ala Asn Glu  Gln Ala Tyr 
    1760                 1765                 1770             


Cys Phe  Lys Ala Pro Ser Ala  Gln Ser Ser Phe Ala  Gly Thr Trp 
    1775                 1780                 1785             


Ser Ala  Lys Glu Ala Val Phe  Lys Ser Leu Gly Val  Lys Ser Gln 
    1790                 1795                 1800             


Gly Gly  Gly Ala Glu Leu Lys  Ser Ile Glu Ile Ser  Arg Asp Gly 
    1805                 1810                 1815             


Asn Gly  Ala Pro Val Val Val  Leu His Gly Ala Ala  Lys Asp Ala 
    1820                 1825                 1830             


Ala Ala  Ser Lys Gly Ile Ser  Ser Val Lys Val Ser  Ile Ser His 
    1835                 1840                 1845             


Asp Asp  Ser Gln Ala Val Ala  Val Ala Val Ala Glu  
    1850                 1855                 1860 


<210>  12
<211>  325
<212>  PRT
<213>  Yarrowia lipolytica

<400>  12

Met Ser Ala Val Pro Ile Glu Phe Asn Val Pro Ser Val Asp Arg Pro 
1               5                   10                  15      


Phe Gly Ile Tyr Leu Trp Ala Ile Phe Asp Gln Ala Trp Glu Lys Leu 
            20                  25                  30          


Phe Gly Trp Pro Ala Ser Ser Phe Ile Phe Val Arg Asn Asp Pro Asn 
        35                  40                  45              


Ile Pro Phe Ser Ser Thr Pro Pro Val Ile Ile Ala Ile Ile Val Tyr 
    50                  55                  60                  


Tyr Ile Val Ile Phe Gly Gly Arg Glu Val Met Arg Asn Leu Ser Pro 
65                  70                  75                  80  


Ile Arg Leu Asn Trp Leu Phe Gln Ile His Asn Ile Phe Leu Thr Leu 
                85                  90                  95      


Leu Ser Gly Met Leu Leu Leu Leu Leu Val Glu Gln Leu Phe Pro Ile 
            100                 105                 110         


Ile Val Arg Gln Gly Ile Leu Tyr Ala Ile Cys Asp Tyr Gly Ser Trp 
        115                 120                 125             


Thr Gln Pro Ile Val Phe Cys Tyr Tyr Leu Asn Tyr Leu Thr Lys Tyr 
    130                 135                 140                 


Phe Glu Leu Ile Asp Thr Val Phe Leu Val Leu Arg Lys Lys Lys Leu 
145                 150                 155                 160 


Thr Phe Leu His Thr Tyr His His Gly Ala Thr Ala Leu Leu Cys Tyr 
                165                 170                 175     


Thr Gln Leu Ile Gly Lys Thr Ser Val Ser Trp Val Pro Ile Thr Leu 
            180                 185                 190         


Asn Leu Phe Val His Val Val Met Tyr Phe Tyr Tyr Phe Leu Ala Ala 
        195                 200                 205             


Arg Gly Ile Arg Val Trp Trp Lys Glu Trp Val Thr Arg Leu Gln Ile 
    210                 215                 220                 


Ile Gln Phe Val Ile Asp Leu Gly Phe Val Tyr Phe Ala Ser Tyr Thr 
225                 230                 235                 240 


Tyr Phe Thr Ser Thr Tyr Trp Pro Trp Met Pro Asn Met Gly Ser Cys 
                245                 250                 255     


Ala Gly Glu Glu Phe Ala Ala Ile Tyr Gly Cys Gly Leu Leu Thr Ser 
            260                 265                 270         


Tyr Leu Phe Leu Phe Ile Ala Phe Tyr Ile Asn Ser Tyr Arg Lys Pro 
        275                 280                 285             


Ser Ser Lys Gly Pro Ser Lys Pro Val Val Ala Val Asp Gly Pro Val 
    290                 295                 300                 


Gly Gly Val Asn Ala Gln Thr Gly Ala Ser Arg Gly Gln Thr Thr Thr 
305                 310                 315                 320 


Arg Ser Arg Arg Ala 
                325 


<210>  13
<211>  304
<212>  PRT
<213>  Yarrowia lipolytica

<400>  13

Met Leu Ser Ser Ile Ser Pro Asp Leu Tyr Ser Ser Phe Ser Phe Lys 
1               5                   10                  15      


Asn Ser Leu Ala Glu Ala Met Pro Ser Val Pro His Glu Leu Ile Asn 
            20                  25                  30          


Ser Lys Thr Leu Ser Trp Met Tyr Asn Ala Ser Leu Asp Ile Arg Val 
        35                  40                  45              


Pro Leu Thr Ile Gly Thr Ile Tyr Ala Val Ser Val His Leu Thr Asn 
    50                  55                  60                  


Ser Ser Glu Arg Ile Lys Lys Arg Gln Pro Ile Ala Phe Ala Lys Thr 
65                  70                  75                  80  


Ala Leu Phe Lys Trp Leu Cys Val Leu His Asn Ala Gly Leu Cys Leu 
                85                  90                  95      


Tyr Ser Ala Trp Thr Phe Val Gly Ile Leu Asn Ala Val Lys His Ala 
            100                 105                 110         


Tyr Gln Ile Thr Gly Asp Ser Ser Ala Pro Phe Ser Phe Asn Thr Leu 
        115                 120                 125             


Trp Gly Ser Phe Cys Ser Arg Asp Ser Leu Trp Val Thr Gly Leu Asn 
    130                 135                 140                 


Tyr Tyr Gly Tyr Trp Phe Tyr Leu Ser Lys Phe Tyr Glu Val Val Asp 
145                 150                 155                 160 


Thr Met Ile Ile Leu Ala Lys Gly Lys Pro Ser Ser Met Leu Gln Thr 
                165                 170                 175     


Tyr His His Thr Gly Ala Met Phe Ser Met Trp Ala Gly Ile Arg Phe 
            180                 185                 190         


Ala Ser Pro Pro Ile Trp Ile Phe Val Val Phe Asn Ser Leu Ile His 
        195                 200                 205             


Thr Ile Met Tyr Phe Tyr Tyr Thr Leu Thr Thr Leu Lys Ile Lys Val 
    210                 215                 220                 


Pro Lys Ile Leu Lys Ala Ser Leu Thr Thr Ala Gln Ile Thr Gln Ile 
225                 230                 235                 240 


Val Gly Gly Gly Ile Leu Ala Ala Ser His Ala Phe Ile Tyr Tyr Lys 
                245                 250                 255     


Asp His Gln Thr Glu Thr Val Cys Ser Cys Leu Thr Thr Gln Gly Gln 
            260                 265                 270         


Phe Phe Ala Leu Ala Val Asn Val Ile Tyr Leu Ser Pro Leu Ala Tyr 
        275                 280                 285             


Leu Phe Ile Ala Phe Trp Ile Arg Ser Tyr Leu Lys Ala Lys Ser Asn 
    290                 295                 300                 


<210>  14
<211>  1604
<212>  DNA
<213>  Yarrowia lipolytica

<400>  14
atgagtgagt atttcccaca aaacaaatgc ccccagcagc gaacacgccc cgacaccgat       60

acacgcagca gcgcggaggt gacacaaatg cctcggattt gcacctgtga tcatgaacac      120

gttacgtcga catgggacac acgtcctgtg taatcgacca ttcagtcaac gaaacagatg      180

ttttaggagg acacctcgag ccagaagatg atcgaccggg gatactaccg gtagttgtgt      240

caccaacact cagctcaagc gctgttatcg tcgtcgcggg gtgatttgac ccctgatcta      300

cgcgtcgcgt acaacaaaac gtggcagatt tggggtttaa tcgccggaca acagaaacga      360

atacgcagag acagtaacgg atggataata caaatcctac ctcgcccctt gatctatcta      420

cgtctctcac atgtcgcatg atccatatcg ttacttccga tctcatgttt gacaaaatcc      480

atacaaggcg aagtgaggca aaccccgaac atatacgtga caacaagcct cgtgtcacta      540

ctatgtggtg gccgccacaa cactgacgtg acgtcctttt tgggacacga cctctgtcac      600

acctttacta tccgctctat actaactcag gcgccgtccc tattgaattc aacgtcccct      660

ccgtggaccg accctttggt atctacctct gggccatctt tgaccaggcc tgggagaagc      720

ttttcggctg gcccgcgtcc tctttcattt tcgtgcgaaa tgaccccaac atcccctttt      780

cctctacccc tcccgtgatc attgccatca ttgtgtacta cattgtcatc tttggcggcc      840

gagaggtgat gcgaaacctg tctcccatcc gactcaactg gctcttccag atccacaaca      900

tcttcctcac ccttctgtcc ggtatgctcc tcctcctcct cgttgagcag ctcttcccca      960

tcattgtccg acagggtatc ctctacgcca tctgcgacta cggatcttgg actcagccca     1020

ttgtcttctg ctactacctc aactacctga ccaagtactt tgagctgatc gacaccgttt     1080

tccttgtgct gcgaaagaag aagctgactt tcctccacac ctaccaccat ggtgccactg     1140

ctcttctgtg ctacacccag ctcattggta agacctcggt ctcttgggtc cccatcaccc     1200

ttaacctgtt tgtccacgtt gtcatgtact tctactactt cctggctgcg cgaggtatcc     1260

gagtgtggtg gaaggagtgg gtcacccggc tccagatcat ccagttcgtt atcgatcttg     1320

gatttgtcta ctttgcctct tacacctact tcacctctac ctactggccc tggatgccca     1380

acatgggctc ttgtgccggc gaggagtttg ctgctattta cggctgtggt ctgctgacct     1440

cttacctctt cctcttcatc gccttctaca tcaactctta ccgaaagccc tcttccaagg     1500

gaccttccaa gcctgttgtt gctgtcgatg gccctgttgg cggcgtcaac gcccagactg     1560

gtgcttctcg aggccagacc actacccgat ctcgacgagc ataa                      1604


<210>  15
<211>  915
<212>  DNA
<213>  Yarrowia lipolytica

<400>  15
atgctctcgt caatctcgcc cgacctatac tcgtccttct cgttcaaaaa ctcgctcgcc       60

gaggccatgc cctccgtgcc acacgaactc atcaactcaa aaacactctc atggatgtac      120

aatgcctctc tggacattcg ggttcctctg actatcggaa ccatctacgc cgtctccgtg      180

cacctgacca actcatctga acgaatcaag aaacgccagc ccattgcctt tgccaagacc      240

gcactcttca agtggctctg tgtcctccac aatgcaggtc tgtgtctcta ctcagcatgg      300

acctttgtcg gtatcctcaa cgccgtcaaa cacgcctacc aaatcacagg agacagctcc      360

gcccccttct ccttcaacac cctctgggga tcgttttgtt cacgtgactc cctctgggtc      420

accggcctca actactacgg atactggttc tatctgtcca aattctacga agtggtggac      480

accatgatca tcctcgcaaa gggaaaaccg tcctcaatgc tccagacata ccaccacacc      540

ggcgccatgt tctccatgtg ggccggcatc cgattcgcct ctccccccat ctggatcttt      600

gtggttttca actccctcat ccacacaatc atgtactttt actacaccct caccaccctc      660

aagatcaagg ttcccaagat cctcaaggca tctctgacca ccgcccagat cacccagatt      720

gtcggaggtg gcatcctggc tgcctcccac gcctttattt attacaagga ccaccagact      780

gagaccgtct gttcttgtct cactacccag ggtcagtttt tcgctctcgc cgtcaatgtc      840

atctatctga gtcctctggc ctatctcttt attgccttct ggattcgatc ttacttgaag      900

gccaagtcca actag                                                       915


<210>  16
<211>  4354
<212>  DNA
<213>  Yarrowia lipolytica

<400>  16
ggatccgtat gccacctatc taaccactcc ggtcgttcag cattgatggg gtggtccaaa       60

tatgagattt ttttataagt aacagcattc taacagaaac taaaggactg tagcaaggac      120

taataggctg tggcgaacat ggcttcagtg taatgtgccc ttgatggacc tcttcaactg      180

tgagcaattg gtgaggttcc actgccctca accaaataga cagtctccct atagtgtact      240

tgtactgtct tgcagagtaa tcaaatgtga tcagaaaacc atgtaccgaa taattgcatc      300

atctacttgt agtatcttca ttttgaacca tgttccattc aaatcacatc tgaatcgact      360

ggtagcatgt gggtgaaagt ctggatttac ttacaacttt agttgggaat attgttgatc      420

caaatgatac cagaaaatac accaaaatat ggccgcaatg gggcatgaat agcactcata      480

ttgcgctaga ccagcttccc aattcactat attgcatata caagtagtag tgctcgttca      540

aaacgcgtcc cgaaaacctg tccaccagtt gcactgttgt ctcctttctg cttggcagat      600

atttacaagc ctcggttgac gatcacttat ttatccgaaa tgccgcagtg agagagtgca      660

ccttagatcg cgtgttttca ggtgtagttt cagcagctga ctacacatac atgtcaccca      720

ctcatcaaca caagcccaac tatcacccga tacaagacta cagtattgtt ttactgtagc      780

agccctgttg ggttccggct gtccttttct caatctcaac cgtctcccaa cgttgggagc      840

agcataaggt ttggaaacaa acgacgcagg aaaaaaaagt tggtttatca gttgggggag      900

ggcgttcaag tagggagagg atatatggta aatgggcgcg tggaatgaag tagagaatgg      960

tttgcttgag aaaacgaccc ttaaattaat catggccatt ttttccccac tcaaaatccc     1020

cccacaacac cctgcaacat acacttccca gcactcaaca aagttgatcc tccctcaacg     1080

tatgccactg catgcatgat acgggggtcg cgattctaaa taaaacgact gtcgtgcctc     1140

aattgaaacg tcacgagaaa tctgtgaact acacacacaa acagttcatt acgagtgagt     1200

cttgaaatat gggatatgag gaggggtttg aagaggttgc aatcgataac tcacgacacg     1260

gacgaaaaag aataaggacc aacacgatct ccagacaacc acagatcagc agtcgaaccc     1320

ccctcaacag cagacaaatg atgttgtgga attgcagtag atgatttctt ctgcgacgct     1380

agtattggct gtcggcgaca ctattctctg acagtgccca atggtctttt tattgtgcac     1440

caaccgctga tttgtggctc aggttttgtg acggcgagag tcattctcgt gatgcatggg     1500

atgattggtc tctttgaagc cgacagatcg acatatttcc acacacagca acgacaatgt     1560

tatcttatcc attgccattc taacccagtg ggtagggata acagggtaat tatcgcttcg     1620

gataactcct gctatacgaa gttatacgaa ttcgcgccca gagagccatt gacgttcttt     1680

ctaatttgga ccgatagccg tatagtccag tctatctata agttcaacta actcgtaact     1740

attaccataa catatacttc actgccccag ataaggttcc gataaaaagt tctgcagact     1800

aaatttattt cagtctcctc ttcaccacca aaatgccctc ctacgaagct cgagctaacg     1860

tccacaagtc cgcctttgcc gctcgagtgc tcaagctcgt ggcagccaag aaaaccaacc     1920

tgtgtgcttc tctggatgtt accaccacca aggagctcat tgagcttgcc gataaggtcg     1980

gaccttatgt gtgcatgatc aagacccata tcgacatcat tgacgacttc acctacgccg     2040

gcactgtgct ccccctcaag gaacttgctc ttaagcacgg tttcttcctg ttcgaggaca     2100

gaaagttcgc agatattggc aacactgtca agcaccagta ccggtgtcac cgaatcgccg     2160

agtggtccga tatcaccaac gcccacggtg tacccggaac cggaatcatt gctggcctgc     2220

gagctggtgc cgaggaaact gtctctgaac agaagaagga ggacgtctct gactacgaga     2280

actcccagta caaggagttc ctagtcccct ctcccaacga gaagctggcc agaggtctgc     2340

tcatgctggc cgagctgtct tgcaagggct ctctggccac tggcgagtac tccaagcaga     2400

ccattgagct tgcccgatcc gaccccgagt ttgtggttgg cttcattgcc cagaaccgac     2460

ctaagggcga ctctgaggac tggcttattc tgacccccgg ggtgggtctt gacgacaagg     2520

gagacgctct cggacagcag taccgaactg ttgaggatgt catgtctacc ggaacggata     2580

tcataattgt cggccgaggt ctgtacggcc agaaccgaga tcctattgag gaggccaagc     2640

gataccagaa ggctggctgg gaggcttacc agaagattaa ctgttagagg ttagactatg     2700

gatatgtaat ttaactgtgt atatagagag cgtgcaagta tggagcgctg ttcagcttgt     2760

atgatggtca gacgacctgt ctgatcgagt atgtatggta ctgcacaacc tgtgtatccg     2820

catggtctgt ccaatggggc atgttgttgt gtttctcgga attcagaata acttcgtata     2880

atgtatgcta tacgaagtta tgtagggata acagggtaat cgtagatcgt gatgagcgat     2940

gtgagatgaa atgaggagga ttttatatgt gttttaattg attgatttat gataggatgg     3000

gccgtaatat gtacatacag tagttcaaca gactggtccg tacgtcaagc catgggacga     3060

caagcctgtt atacagtatg tactgtagta tgtacagtac aatttgtgag agttcgtgat     3120

tcaaaaagaa gatgatgcct ctcacaataa aagagacaaa aataaatggt ccctagcagg     3180

atcgaactgc tgatcttcgc gttgcaaaga ggctaatttc ttattagcac gacgccttaa     3240

ccaactgggc caagggacct atttttatac aaaataaact gtggccccta ctatccaaat     3300

tcagtcaatt tcaaacctga atcatcagaa taaaaacaaa acaaaaaacg aaatcgcttc     3360

aaaacgacac tgatgtcaag gtggcagttt tataatactg tgatgatact aaattttaag     3420

tcaagctcga gtttccacta ctcataacgt atggtcatgc ggcagtgtct tgtgacattg     3480

aactccggat taatagagct ttgaaagccg aaatgtgagg aattttgggt agtgggtata     3540

aattgatctc gttattaaga ggaatactga cgttcccctt catctcttgt tgtactgtca     3600

cttgtcaaca cacctccagc gatacatgcg ccatgttatc acttatcgtt atgttagggt     3660

tctgcatttg catagtgcaa gtgctaaaaa aatatttgcc ctgtagagct ctacacgaca     3720

aaaccacaca ctcataatcg atacaaaatg agctacacga tctcagcagc agctctatat     3780

tctgcaacga tatacctgtt gtttctgcgc gacagaagtc gacaaagtct cgagcgaagt     3840

gaaattctgg ctgcaaggga ggctacaaac tacagcatca gcaatacgac tattttctcc     3900

ggagtgacag ctaaaagcta cggtttcaat gcgcattaca gaggggttcc cgcaacgtac     3960

tggtcgtggc tgctgttggt ccagggtctg tttgtgctgg gcatgttcta catggactgg     4020

ccaacagttg gatatggagc acttctcgtc tggagctttt atgcttatgc cacggagcag     4080

tgtgacaagc aggggcgcat gagtggcctc aagatccaga gcatgtttgg tccggtcaaa     4140

acgtttgctg gccgggacaa gttccactgg tacgctgttg tcaacacggg tacctctctt     4200

gatctgttgc cagagtcatc tgatgatgag ctttctgagg aggaggagga ggacgtcgag     4260

atggacggcg acgtcaacat ggaagaaact taccggactc tgagacaaaa tatgcatagt     4320

ttcgaggaga ttatggggga gggagaagaa gctt                                 4354


<210>  17
<211>  1642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TAL_KSr

<400>  17
aacctgaccc cggaccaagt ggtggctatc gccagcaaca atggcggcaa gcaagcgctc       60

gaaacggtgc agcggctgtt gccggtgctg tgccaggacc atggcctgac cccggaccaa      120

gtggtggcta tcgccagcaa cggtggcggc aagcaagcgc tcgaaacggt gcagcggctg      180

ttgccggtgc tgtgccagga ccatggcctg accccggacc aagtggtggc tatcgccagc      240

aacggtggcg gcaagcaagc gctcgaaacg gtgcagcggc tgttgccggt gctgtgccag      300

gaccatggcc tgactccgga ccaagtggtg gctatcgcca gccacgatgg cggcaagcaa      360

gcgctcgaaa cggtgcagcg gctgttgccg gtgctgtgcc aggaccatgg cctgactccg      420

gaccaagtgg tggctatcgc cagccacgat ggcggcaagc aagcgctcga aacggtgcag      480

cggctgttgc cggtgctgtg ccaggaccat ggcctgaccc cggaccaagt ggtggctatc      540

gccagcaaca atggcggcaa gcaagcgctc gaaacggtgc agcggctgtt gccggtgctg      600

tgccaggacc atggcctgac cccggaccaa gtggtggcta tcgccagcaa caatggcggc      660

aagcaagcgc tcgaaacggt gcagcggctg ttgccggtgc tgtgccagga ccatggcctg      720

accccggacc aagtggtggc tatcgccagc aacggtggcg gcaagcaagc gctcgaaacg      780

gtgcagcggc tgttgccggt gctgtgccag gaccatggcc tgaccccgga ccaagtggtg      840

gctatcgcca gcaacggtgg cggcaagcaa gcgctcgaaa cggtgcagcg gctgttgccg      900

gtgctgtgcc aggaccatgg cctgactccg gaccaagtgg tggctatcgc cagccacgat      960

ggcggcaagc aagcgctcga aacggtgcag cggctgttgc cggtgctgtg ccaggaccat     1020

ggcctgaccc cggaccaagt ggtggctatc gccagccacg atggcggcaa gcaagcgctc     1080

gaaacggtgc agcggctgtt gccggtgctg tgccaggacc atggcctgac cccggaccaa     1140

gtggtggcta tcgccagcaa caatggcggc aagcaagcgc tcgaaacggt gcagcggctg     1200

ttgccggtgc tgtgccagga ccatggcctg accccggacc aagtggtggc tatcgccagc     1260

aacaatggcg gcaagcaagc gctcgaaacg gtgcagcggc tgttgccggt gctgtgccag     1320

gaccatggcc tgaccccgga ccaagtggtg gctatcgcca gcaacggtgg cggcaagcaa     1380

gcgctcgaaa cggtgcagcg gctgttgccg gtgctgtgcc aggaccatgg cctgaccccg     1440

gaccaagtgg tggctatcgc cagcaacatt ggcggcaagc aagcgctcga aacggtgcag     1500

cggctgttgc cggtgctgtg ccaggaccat ggcctgaccc cggaccaagt ggtggctatc     1560

gccagcaacg gtggcggcaa gcaagcgctc gaaagcattg tggcccagct gagccggcct     1620

gatccggcgt tggccgcgtt ga                                              1642


<210>  18
<211>  1642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TAL_KSl

<400>  18
aacctgaccc cggaccaagt ggtggctatc gccagcaaca atggcggcaa gcaagcgctc       60

gaaacggtgc agcggctgtt gccggtgctg tgccaggacc atggcctgac cccggaccaa      120

gtggtggcta tcgccagcaa cattggcggc aagcaagcgc tcgaaacggt gcagcggctg      180

ttgccggtgc tgtgccagga ccatggcctg accccggacc aagtggtggc tatcgccagc      240

aacattggcg gcaagcaagc gctcgaaacg gtgcagcggc tgttgccggt gctgtgccag      300

gaccatggcc tgactccgga ccaagtggtg gctatcgcca gccacgatgg cggcaagcaa      360

gcgctcgaaa cggtgcagcg gctgttgccg gtgctgtgcc aggaccatgg cctgaccccg      420

gaccaagtgg tggctatcgc cagcaacatt ggcggcaagc aagcgctcga aacggtgcag      480

cggctgttgc cggtgctgtg ccaggaccat ggcctgaccc cggaccaagt ggtggctatc      540

gccagcaacg gtggcggcaa gcaagcgctc gaaacggtgc agcggctgtt gccggtgctg      600

tgccaggacc atggcctgac cccggaccaa gtggtggcta tcgccagcaa caatggcggc      660

aagcaagcgc tcgaaacggt gcagcggctg ttgccggtgc tgtgccagga ccatggcctg      720

actccggacc aagtggtggc tatcgccagc cacgatggcg gcaagcaagc gctcgaaacg      780

gtgcagcggc tgttgccggt gctgtgccag gaccatggcc tgactccgga ccaagtggtg      840

gctatcgcca gccacgatgg cggcaagcaa gcgctcgaaa cggtgcagcg gctgttgccg      900

gtgctgtgcc aggaccatgg cctgaccccg gaccaagtgg tggctatcgc cagcaacggt      960

ggcggcaagc aagcgctcga aacggtgcag cggctgttgc cggtgctgtg ccaggaccat     1020

ggcctgaccc cggaccaagt ggtggctatc gccagccacg atggcggcaa gcaagcgctc     1080

gaaacggtgc agcggctgtt gccggtgctg tgccaggacc atggcctgac cccggaccaa     1140

gtggtggcta tcgccagcaa caatggcggc aagcaagcgc tcgaaacggt gcagcggctg     1200

ttgccggtgc tgtgccagga ccatggcctg actccggacc aagtggtggc tatcgccagc     1260

cacgatggcg gcaagcaagc gctcgaaacg gtgcagcggc tgttgccggt gctgtgccag     1320

gaccatggcc tgaccccgga ccaagtggtg gctatcgcca gcaacattgg cggcaagcaa     1380

gcgctcgaaa cggtgcagcg gctgttgccg gtgctgtgcc aggaccatgg cctgaccccg     1440

gaccaagtgg tggctatcgc cagcaacaat ggcggcaagc aagcgctcga aacggtgcag     1500

cggctgttgc cggtgctgtg ccaggaccat ggcctgaccc cggaccaagt ggtggctatc     1560

gccagcaaca atggcggcaa gcaagcgctc gaaagcattg tggcccagct gagccggcct     1620

gatccggcgt tggccgcgtt ga                                              1642


<210>  19
<211>  2022
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Matrix I1220F

<400>  19
aacggtggct tccagtacat tcccgacctc aagggagttg ttggaaagat ccgacgagac       60

attgtggaga cctccgagat ccgacgggct gtggctcagg agactgccat tgaacagaag      120

gtggtcaacg gcccccacgc cgatcttcct taccagaagg tcgaggtcaa gccccgagcc      180

aacctcaagt ttgacttccc caccctcaaa tcctacgccg aggtcaagga gctgtctcct      240

gctggtgatg ctctggaggg tcttctggat ctctcttccg tcattgttgt cactggtttc      300

gccgaggtcg gtccttgggg taacgcccga acccgatggg acatggaggc caacggtgtc      360

ttctcccttg agggtgccat tgagatggcc tggatcatgg gtctgatcaa gcaccacaat      420

ggtcccctgc ccggcatgcc tcagtactct ggctggatcg ataccaagac caagcagccc      480

gtcgatgacc gagatatcaa gaccaagtac gaggactacc tgcttgagca cgccggtatc      540

cgactcattg agcctgagct gttccacggc tacaacccca agaagaagac cttcctccag      600

gaggttattg tggagcacga tctcgagccc tttgaggcct ccaaggagtc tgctgagcaa      660

tttgctctcg agcagggcgc gaacgttgag atcttcgccg tccccgagtc cgaccagtgg      720

actgtgcgac ttctcaaggg cgccaagctc ctcattccca aggccctcaa gtttgaccga      780

cttgtggccg gccagattcc cactggatgg gatgcccgac gatacggtat tcccgaggac      840

atttgtgacc aggttgaccc catcactctg tacgctcttg tctccactgt tgaggctctg      900

ttggcctccg gtattaccga cccctacgag ttctacaagt acgtccacgt gtccgaggtc      960

ggtaactgct ctggatccgg catgggtggt ttcaccgccc tcagaggtat gtttaaggac     1020

cggttcatgg acaagcctgt tcagaacgat attctccagg agtccttcat caacaccatg     1080

tctgcctggg tcaacatgtt gctgctctcc tcttccggtc ccatcaagac ccccgttgga     1140

gcttgtgcca ctgctgtcga gtctgtggac attggttgcg aaaccattct gtccggcaag     1200

gccagaatct gtctggtcgg tggttacgat gatttccagg aggagtcttc tcaggagttt     1260

gcaaacatga acgcaacatc caacgctgag accgagatca ctcacggccg aactccggcc     1320

gagatgtctc gacccatcac ttccacacga gccggtttca tggaggctca gggtgctgga     1380

acccaggtgc tgatggccgc cgacctcgcc atcgccatgg gtgtgcccat ctactgtatc     1440

gttggttacg tcaacactgc caccgacaag attggccgat ctgtgcctgc tcccggtaag     1500

ggtatcctga ccactgctcg agagcaccag actctcaaac acgccaaccc tctcctcaac     1560

atcaagtacc gaaagcgaca gctcgattct cgactccgag acattaagcg atgggctgag     1620

ggcgaaatgg aggctattga cattgagctt gacgacgtgt ctgacgccga caaggagtcc     1680

ttcatccagg agcgatctgc ccacatccag tctcagtccg atcgaatgat ccgagaggct     1740

aagaactctt ggggtaacgc ctttttcaag caggacgccc gaatctcccc catccgagga     1800

gcgctggcaa cctacggtct caccattgat gacatctccg tcgcttcttt ccatggtaca     1860

tccaccaagg ccaacgagaa gaacgagacc accaccgtca acgccatgct ggagcatctc     1920

ggcagaaccc ggggtaaccc tgtctacggt atcttccaga agtaccttac tggtcacccc     1980

aagggagctg ctggtgcctg gatgctcaac ggagccatcc aa                        2022


<210>  20
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer alphaFAS F

<400>  20
acccgaagga tcccacaatg caccccgaag tcgaacaaga ac                          42


<210>  21
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer alphaFAS R

<400>  21
accacagaca ccctaggcta ctcggcaaca gcaacagcca                             40


<210>  22
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FAS_S1305T  F

<400>  22
atgatttcca ggaggagact tctcaggagt ttgca                                  35


<210>  23
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FAS_S1305T  R

<400>  23
tgcaaactcc tgagaagtct cctcctggaa atcat                                  35


<210>  24
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FAS_M1217F_F

<400>  24
ctgttccggt tccggtttcg gtggtatcac cg                                     32


<210>  25
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FAS_M1217F_R

<400>  25
cggtgatacc accgaaaccg gaaccggaac ag                                     32


<210>  26
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FAS_M1217Y_F

<400>  26
aactgttccg gttccggtta cggtggtatc accgcc                                 36


<210>  27
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FAS_M1217Y_R

<400>  27
ggcggtgata ccaccgtaac cggaaccgga acagtt                                 36


<210>  28
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FAS_I1220M F

<400>  28
tccggtatgg gtggtatgac cgccctg                                           27


<210>  29
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FAS_I1220M R

<400>  29
cagggcggtc ataccaccca taccgga                                           27


<210>  30
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FAS_I1220F F

<400>  30
ccggtatggg tggtttcacc gccctgc                                           27


<210>  31
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FAS_I1220F R

<400>  31
gcagggcggt gaaaccaccc ataccgg                                           27


<210>  32
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FAS_I1220W F

<400>  32
tccggttccg gtatgggtgg ttggaccgcc ctgcg                                  35


<210>  33
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FAS_I1220W R

<400>  33
cgcagggcgg tccaaccacc cataccggaa ccgga                                  35


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer KS-T7_F

<400>  34
tggatgggat gcccgacgat a                                                 21


<210>  35
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer KS-T7_R

<400>  35
gagtgatctc ggtctcagcg tt                                                22


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer HRscreening_R

<400>  36
ggtccttaaa catacctctg                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer WTscreening_R

<400>  37
ggtccttgaa catgcctcgc                                                   20


<210>  38
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer KS_P1

<400>  38
gtcgttgaga acaaggctgt ttctg                                             25


<210>  39
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer KS_T2

<400>  39
gaatttggat agtaggggcc acagt                                             25


<210>  40
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KS-TALEN 1F

<400>  40
aacggtggct tccagtacat tcc                                               23


<210>  41
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KS-TALEN 4R

<400>  41
ttggatggct ccgttgagca tcca                                              24


<210>  42
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220L  3F

<400>  42
atgggtggtc tgaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  43
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220L 2R

<400>  43
agggcggtca gaccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  44
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220V 3F

<400>  44
atgggtggtg tcaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  45
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220V 2R

<400>  45
agggcggtga caccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  46
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220S 3F

<400>  46
atgggtggtt ccaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  47
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220S 2R

<400>  47
agggcggtgg aaccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  48
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220P 3F

<400>  48
atgggtggtc ccaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  49
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220P 2R

<400>  49
agggcggtgg gaccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  50
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220T 3F

<400>  50
atgggtggta ccaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  51
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220T 2R

<400>  51
agggcggtgg taccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  52
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220A 3F

<400>  52
atgggtggtg ccaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  53
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220A 2R

<400>  53
agggcggtgg caccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  54
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220Y 3F

<400>  54
atgggtggtt acaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  55
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220Y 2R

<400>  55
agggcggtgt aaccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  56
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220H 3F

<400>  56
atgggtggtc acaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  57
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220H 2R

<400>  57
agggcggtgt gaccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  58
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220Q 3F

<400>  58
atgggtggtc agaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  59
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220Q 2R

<400>  59
agggcggtct gaccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  60
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220N 3F

<400>  60
atgggtggta acaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  61
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220N 2R

<400>  61
agggcggtgt taccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  62
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220K 3F

<400>  62
atgggtggta agaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  63
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220K 2R

<400>  63
agggcggtct taccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  64
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220D 3F

<400>  64
atgggtggtg acaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  65
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220D 2R

<400>  65
agggcggtgt caccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  66
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220E 3F

<400>  66
atgggtggtg agaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  67
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220E 2R

<400>  67
agggcggtct caccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  68
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220C 3F

<400>  68
atgggtggtt gcaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  69
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220C 2R

<400>  69
agggcggtgc aaccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  70
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220M 3F

<400>  70
atgggtggta tgaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  71
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220M 2R

<400>  71
agggcggtca taccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  72
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220W 3F

<400>  72
atgggtggtt ggaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  73
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220W 2R

<400>  73
agggcggtcc aaccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  74
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer matrix KSI1220F 3F

<400>  74
atgggtggtt tcaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  75
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer matrix KSI1220F 2R

<400>  75
agggcggtga aaccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  76
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220R 3F

<400>  76
atgggtggtc gaaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  77
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220R 2R

<400>  77
agggcggttc gaccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  78
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220G 3F

<400>  78
atgggtggtg gcaccgccct cagaggtatg tttaaggacc ggttcatgga c                51


<210>  79
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer Matrix KSI1220G 2R

<400>  79
agggcggtgc caccacccat gccggatcca gagcagttac cgacctcgga                  50


<210>  80
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FAS_S1305V_ F

<400>  80
cgatgatttc caggaggagg tttctcagga gtttgcaaac                             40


<210>  81
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer FAS_ S1305V_ R

<400>  81
gtttgcaaac tcctgagaaa cctcctcctg gaaatcatcg                             40


