                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION
 
<120> TARGETED T CELLS WITH CYTOTOXICITY TOWARD IMMUNOSUPPRESSIVE CELLS

<130> 030258-089581-PCT

<140> PCT/US2018/013095
<141> 2018-01-10

<150> 62/444,595
<151> 2017-01-10

<160> 13    

<170> PatentIn version 3.5

<210> 1
<211> 321
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcctgggcga cagggtgacc       60

atcacctgcc aggccagcca gagcatcagc agctacctgg cctggtacca gcagaagccc      120

ggccaggccc ccaacatcct gatctacggc gccagcaggc tgaagaccgg cgtgcccagc      180

aggttcagcg gcagcggcag cggcaccagc ttcaccctga ccatcagcgg cctggaggcc      240

gaggacgccg gcacctacta ctgccagcag tacgccagcg tgcccgtgac cttcggccag      300

ggcaccaagg tggagctgaa g                                                321


<210> 2
<211> 417
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
atgaagttgt ggctgaactg gattttcctt gtaacacttt taaatgatat ccagtgtgag       60

gtgaagctgg tggagtctgg aggaggcttg gtacagcctg ggggttctct gagtctctcc      120

tgtgcagctt ctggattcac cttcactgat tactacatga gctgggtccg ccagcctcca      180

gggaaggcac ttgagtggtt gggttttatt agaaacaaac ctaatggtta cacaacagag      240

tacagtgcat ctgtgaaggg tcggttcacc atctccagag ataattccca aagcatcctc      300

tatcttcaaa tgaatgtcct gagagctgag gacagtgcca cttattactg tgcaagatat      360

acgggggggg gttactttga ctactggggc caaggcacca ctctcacagt ctcctca         417


<210> 3
<211> 381
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagactcacc      120

atcagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      180

gatggaactg ttaaactcct gatctactac acatcaagat tacactcagg agtcccatca      240

aggttcagtg gcagtgggtc tggaacagat tattctctca ccattagcaa cctggagcaa      300

gcagatattg ccacttactt ttgccaacag ggtgatacac ttccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa a                                                381


<210> 4
<211> 60
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
ggaggcggag gatctggcgg cggaggaagt ggcggcggag gatctggcgg cggaggaagc       60


<210> 5
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5
Met Ala Thr Gly Ser Arg Thr Pro Trp Leu Gln Glu Gly Ser Ala Phe 
1               5                   10                  15      


Pro Thr 
        


<210> 6
<211> 16
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Leu Trp Met Arg Gly Pro Asp Pro Ala Ala Ala Phe Val Asn 
1               5                   10                  15      


<210> 7
<211> 14
<212> PRT
<213> Zea mays

<400> 7
Met Ala Ala Lys Ser Ala Ser Ala Ala Thr Ala Ser Ile Phe 
1               5                   10                  


<210> 8
<211> 8
<212> PRT
<213> Influenza virus

<400> 8
Met Lys Ala Lys Gly Asp Gln Ile 
1               5               


<210> 9
<211> 351
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln 
        35                  40                  45              


Ser Ile Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Asn Ile Leu Ile Tyr Gly Ala Ser Arg Leu Lys Thr Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Gly Leu Glu Ala Glu Asp Ala Gly Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Ala Ser Val Pro Val Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys 
        115                 120                 125             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    130                 135                 140                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
145                 150                 155                 160 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
                165                 170                 175     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            180                 185                 190         


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        195                 200                 205             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    210                 215                 220                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
225                 230                 235                 240 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                245                 250                 255     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            260                 265                 270         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        275                 280                 285             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    290                 295                 300                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
305                 310                 315                 320 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                325                 330                 335     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            340                 345                 350     


<210> 10
<211> 530
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Lys Leu Trp Leu Asn Trp Ile Phe Leu Val 
            20                  25                  30          


Thr Leu Leu Asn Asp Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly 
        35                  40                  45              


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala 
    50                  55                  60                  


Ser Gly Phe Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro 
65                  70                  75                  80  


Pro Gly Lys Ala Leu Glu Trp Leu Gly Phe Ile Arg Asn Lys Pro Asn 
                85                  90                  95      


Gly Tyr Thr Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Ile 
            100                 105                 110         


Ser Arg Asp Asn Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Val Leu 
        115                 120                 125             


Arg Ala Glu Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Tyr Thr Gly Gly 
    130                 135                 140                 


Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Ser Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu 
            180                 185                 190         


Leu Cys Phe Gln Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr 
        195                 200                 205             


Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Leu Thr Ile Ser Cys Arg 
    210                 215                 220                 


Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
225                 230                 235                 240 


Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His Ser 
                245                 250                 255     


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
            260                 265                 270         


Leu Thr Ile Ser Asn Leu Glu Gln Ala Asp Ile Ala Thr Tyr Phe Cys 
        275                 280                 285             


Gln Gln Gly Asp Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
    290                 295                 300                 


Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
305                 310                 315                 320 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
                325                 330                 335     


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
            340                 345                 350         


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
        355                 360                 365             


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
    370                 375                 380                 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
385                 390                 395                 400 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                405                 410                 415     


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            420                 425                 430         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        435                 440                 445             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    450                 455                 460                 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
465                 470                 475                 480 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                485                 490                 495     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            500                 505                 510         


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        515                 520                 525             


Pro Arg 
    530 


<210> 11
<211> 530
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu 
            20                  25                  30          


Leu Leu Cys Phe Gln Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr 
        35                  40                  45              


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Leu Thr Ile Ser Cys 
    50                  55                  60                  


Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
65                  70                  75                  80  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His 
                85                  90                  95      


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
            100                 105                 110         


Ser Leu Thr Ile Ser Asn Leu Glu Gln Ala Asp Ile Ala Thr Tyr Phe 
        115                 120                 125             


Cys Gln Gln Gly Asp Thr Leu Pro Trp Thr Phe Gly Gly Gly Thr Lys 
    130                 135                 140                 


Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Gly Gly Gly Ser Met Lys Leu Trp Leu Asn Trp Ile 
                165                 170                 175     


Phe Leu Val Thr Leu Leu Asn Asp Ile Gln Cys Glu Val Lys Leu Val 
            180                 185                 190         


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ser Leu Ser 
        195                 200                 205             


Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val 
    210                 215                 220                 


Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Gly Phe Ile Arg Asn 
225                 230                 235                 240 


Lys Pro Asn Gly Tyr Thr Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg 
                245                 250                 255     


Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile Leu Tyr Leu Gln Met 
            260                 265                 270         


Asn Val Leu Arg Ala Glu Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Tyr 
        275                 280                 285             


Thr Gly Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
    290                 295                 300                 


Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro 
305                 310                 315                 320 


Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro 
                325                 330                 335     


Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
            340                 345                 350         


Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
        355                 360                 365             


Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu 
    370                 375                 380                 


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
385                 390                 395                 400 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
                405                 410                 415     


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
            420                 425                 430         


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
        435                 440                 445             


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
    450                 455                 460                 


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
465                 470                 475                 480 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
                485                 490                 495     


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
            500                 505                 510         


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
        515                 520                 525             


Pro Arg 
    530 


<210> 12
<211> 675
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro 
            20                  25                  30          


Leu Ala Leu Leu Leu His Ala Ala Arg Pro Gln Val Gln Leu Lys Gln 
        35                  40                  45              


Ser Gly Pro Gly Leu Val Gln Pro Ser Gln Ser Leu Ser Ile Thr Cys 
    50                  55                  60                  


Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly Val His Trp Val Arg 
65                  70                  75                  80  


Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu Gly Val Ile Trp Ser Gly 
                85                  90                  95      


Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser Arg Leu Ser Ile Asn 
            100                 105                 110         


Lys Asp Asn Ser Lys Ser Gln Val Phe Phe Lys Met Asn Ser Leu Gln 
        115                 120                 125             


Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala Arg Ala Leu Thr Tyr Tyr 
    130                 135                 140                 


Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
145                 150                 155                 160 


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Gly Ser Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu 
            180                 185                 190         


Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln 
        195                 200                 205             


Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser 
    210                 215                 220                 


Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro 
225                 230                 235                 240 


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile 
                245                 250                 255     


Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn 
            260                 265                 270         


Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        275                 280                 285             


Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
    290                 295                 300                 


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
305                 310                 315                 320 


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
                325                 330                 335     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            340                 345                 350         


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        355                 360                 365             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    370                 375                 380                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
385                 390                 395                 400 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                405                 410                 415     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            420                 425                 430         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        435                 440                 445             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    450                 455                 460                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
465                 470                 475                 480 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                485                 490                 495     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg Pro 
            500                 505                 510         


Gly Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly 
        515                 520                 525             


Asp Val Glu Glu Asn Pro Gly Pro Arg Thr Ala Met Glu Thr Asp Thr 
    530                 535                 540                 


Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro Gly Ser Thr Gly Asp 
545                 550                 555                 560 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
                565                 570                 575     


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            580                 585                 590         


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Asn Ile Leu Ile 
        595                 600                 605             


Tyr Gly Ala Ser Arg Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly 
    610                 615                 620                 


Ser Gly Ser Gly Thr Ser Phe Thr Leu Thr Ile Ser Gly Leu Glu Ala 
625                 630                 635                 640 


Glu Asp Ala Gly Thr Tyr Tyr Cys Gln Gln Tyr Ala Ser Val Pro Val 
                645                 650                 655     


Thr Phe Gly Gln Gly Thr Lys Val Glu Leu Lys His His His His His 
            660                 665                 670         


His Ser Gly 
        675 


<210> 13
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Arg Gly Asp Ser 
1               


