                         SEQUENCE LISTING

<110>  BioNTech AG et al.
 
<120>  ENGINEERED CELLS FOR INDUCING TOLERANCE

<130>  674-208 PCT

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 
65                  70                  75                  80  


Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 
                85                  90                  95      


Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
            100                 105                 110         


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
        115                 120                 125             


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
    130                 135                 140                 


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
145                 150                 155                 160 


Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
                165                 170                 175     


Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
            180                 185                 190         


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 
        195                 200                 205             


Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 
    210                 215                 220                 


Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 
225                 230                 235                 240 


Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 
                245                 250                 255     


Ile Asp Cys Ile Gly Asn Glu Thr Glu Leu Leu Arg Asp Thr Phe Thr 
            260                 265                 270         


Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly 
        275                 280                 285             


Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp 
    290                 295                 300                 


Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser 
305                 310                 315                 320 


Val Tyr Gly Val Asp Gln Thr His Ser Gly Leu Pro Leu His His Ile 
                325                 330                 335     


Arg Arg Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro 
            340                 345                 350         


Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu 
        355                 360                 365             


Asp Ser Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu 
    370                 375                 380                 


Phe Lys Ala Gln Lys Arg Gly Leu Cys Thr Val His Arg Glu Ala Asp 
385                 390                 395                 400 


Phe Phe Trp Ser Leu Cys Thr Ala Asp Met Ser Leu Leu Glu Gln Ser 
                405                 410                 415     


His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg 
            420                 425                 430         


Gln Glu Arg Lys Arg Pro Leu Leu Asp Leu His Ile Glu Leu Asn Gly 
        435                 440                 445             


Tyr Met Tyr Asp Trp Asn Ser Arg Val Ser Ala Lys Glu Lys Tyr Tyr 
    450                 455                 460                 


Val Trp Leu Gln His Thr Leu Arg Lys Lys Leu Ile Leu Ser Tyr Thr 
465                 470                 475                 480 


<210>  2
<211>  1443
<212>  DNA
<213>  Homo sapiens

<400>  2
atgtctgctg aagtcatcca tcaggttgaa gaagcacttg atacagatga gaaggagatg       60

ctgctctttt tgtgccggga tgttgctata gatgtggttc cacctaatgt cagggacctt      120

ctggatattt tacgggaaag aggtaagctg tctgtcgggg acttggctga actgctctac      180

agagtgaggc gatttgacct gctcaaacgt atcttgaaga tggacagaaa agctgtggag      240

acccacctgc tcaggaaccc tcaccttgtt tcggactata gagtgctgat ggcagagatt      300

ggtgaggatt tggataaatc tgatgtgtcc tcattaattt tcctcatgaa ggattacatg      360

ggccgaggca agataagcaa ggagaagagt ttcttggacc ttgtggttga gttggagaaa      420

ctaaatctgg ttgccccaga tcaactggat ttattagaaa aatgcctaaa gaacatccac      480

agaatagacc tgaagacaaa aatccagaag tacaagcagt ctgttcaagg agcagggaca      540

agttacagga atgttctcca agcagcaatc caaaagagtc tcaaggatcc ttcaaataac      600

ttcaggctcc ataatgggag aagtaaagaa caaagactta aggaacagct tggcgctcaa      660

caagaaccag tgaagaaatc cattcaggaa tcagaagctt ttttgcctca gagcatacct      720

gaagagagat acaagatgaa gagcaagccc ctaggaatct gcctgataat cgattgcatt      780

ggcaatgaga cagagcttct tcgagacacc ttcacttccc tgggctatga agtccagaaa      840

ttcttgcatc tcagtatgca tggtatatcc cagattcttg gccaatttgc ctgtatgccc      900

gagcaccgag actacgacag ctttgtgtgt gtcctggtga gccgaggagg ctcccagagt      960

gtgtatggtg tggatcagac tcactcaggg ctccccctgc atcacatcag gaggatgttc     1020

atgggagatt catgccctta tctagcaggg aagccaaaga tgttttttat tcagaactat     1080

gtggtgtcag agggccagct ggaggacagc agcctcttgg aggtggatgg gccagcgatg     1140

aagaatgtgg aattcaaggc tcagaagcga gggctgtgca cagttcaccg agaagctgac     1200

ttcttctgga gcctgtgtac tgcggacatg tccctgctgg agcagtctca cagctcacca     1260

tccctgtacc tgcagtgcct ctcccagaaa ctgagacaag aaagaaaacg cccactcctg     1320

gatcttcaca ttgaactcaa tggctacatg tatgattgga acagcagagt ttctgccaag     1380

gagaaatatt atgtctggct gcagcacact ctgagaaaga aacttatcct ctcctacaca     1440

taa                                                                   1443


<210>  3
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 
65                  70                  75                  80  


Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 
                85                  90                  95      


Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
            100                 105                 110         


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
        115                 120                 125             


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
    130                 135                 140                 


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
145                 150                 155                 160 


Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
                165                 170                 175     


Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
            180                 185                 190         


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Met Ile Thr Pro Tyr Ala 
        195                 200                 205             


His Cys Pro Asp Leu Lys Ile Leu Gly Asn Cys Ser Met 
    210                 215                 220     


<210>  4
<211>  666
<212>  DNA
<213>  Homo sapiens

<400>  4
atgtctgctg aagtcatcca tcaggttgaa gaagcacttg atacagatga gaaggagatg       60

ctgctctttt tgtgccggga tgttgctata gatgtggttc cacctaatgt cagggacctt      120

ctggatattt tacgggaaag aggtaagctg tctgtcgggg acttggctga actgctctac      180

agagtgaggc gatttgacct gctcaaacgt atcttgaaga tggacagaaa agctgtggag      240

acccacctgc tcaggaaccc tcaccttgtt tcggactata gagtgctgat ggcagagatt      300

ggtgaggatt tggataaatc tgatgtgtcc tcattaattt tcctcatgaa ggattacatg      360

ggccgaggca agataagcaa ggagaagagt ttcttggacc ttgtggttga gttggagaaa      420

ctaaatctgg ttgccccaga tcaactggat ttattagaaa aatgcctaaa gaacatccac      480

agaatagacc tgaagacaaa aatccagaag tacaagcagt ctgttcaagg agcagggaca      540

agttacagga atgttctcca agcagcaatc caaaagagtc tcaaggatcc ttcaaataac      600

ttcaggatga taacacccta tgcccattgt cctgatctga aaattcttgg aaattgttcc      660

atgtga                                                                 666


<210>  5
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Ala Glu Val Ile Gln Val Glu Glu Ala Leu Asp Thr Asp Glu 
1               5                   10                  15      


Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val Val 
            20                  25                  30          


Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly Lys 
        35                  40                  45              


Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg Phe 
    50                  55                  60                  


Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Thr Lys Ala Val Glu Thr 
65                  70                  75                  80  


His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu Met 
                85                  90                  95      


Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu Ile 
            100                 105                 110         


Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu Lys 
        115                 120                 125             


Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val Ala 
    130                 135                 140                 


Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His Arg 
145                 150                 155                 160 


Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln Gly 
                165                 170                 175     


Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys Ser 
            180                 185                 190         


Leu Lys Asp Pro Ser Asn Asn Phe Arg Val Ser Leu Glu Lys Thr Tyr 
        195                 200                 205             


Gly Ile Pro Ala 
    210         


<210>  6
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  6
atgtctgctg aagtcatcca ggttgaagaa gcacttgata cagatgagaa ggagatgctg       60

ctctttttgt gccgggatgt tgctatagat gtggttccac ctaatgtcag ggaccttctg      120

gatattttac gggaaagagg taagctgtct gtcggggact tggctgaact gctctacaga      180

gtgaggcgat ttgacctgct caaacgtatc ttgaagatgg acacaaaagc tgtggagacc      240

cacctgctca ggaaccctca ccttgtttcc gactatagag tgctgatggc agagattggt      300

gaggatttgg ataaatctga tgtgtcctca ttaattttcc tcatgaagga ttacatgggc      360

cgaggcaaga taagcaagga gaagagtttc ttggaccttg tggttgagtt ggagaaacta      420

aatctggttg ccccagatca actggattta ttagaaaaat gcctaaagaa catccacaga      480

atagacctga agacaaaaat ccagaagtac aagcagtctg ttcaaggagc agggacaagt      540

tacaggaatg ttctccaagc agcaatccaa aagagtctca aggatccttc aaataacttc      600

agggtgagtc tggagaaaac atatggaatc ccagcatga                             639


<210>  7
<211>  188
<212>  PRT
<213>  Viral sequence

<400>  7

Met Ala Thr Tyr Glu Val Leu Cys Glu Val Ala Arg Lys Leu Gly Thr 
1               5                   10                  15      


Asp Asp Arg Glu Val Val Leu Phe Leu Leu Asn Val Phe Ile Pro Gln 
            20                  25                  30          


Pro Thr Leu Ala Gln Leu Ile Gly Ala Leu Arg Ala Leu Lys Glu Glu 
        35                  40                  45              


Gly Arg Leu Thr Phe Pro Leu Leu Ala Glu Cys Leu Phe Arg Ala Gly 
    50                  55                  60                  


Arg Arg Asp Leu Leu Arg Asp Leu Leu His Leu Asp Pro Arg Phe Leu 
65                  70                  75                  80  


Glu Arg His Leu Ala Gly Thr Met Ser Tyr Phe Ser Pro Tyr Gln Leu 
                85                  90                  95      


Thr Val Leu His Val Asp Gly Glu Leu Cys Ala Arg Asp Ile Arg Ser 
            100                 105                 110         


Leu Ile Phe Leu Ser Lys Asp Thr Ile Gly Ser Arg Ser Thr Pro Gln 
        115                 120                 125             


Thr Phe Leu His Trp Val Tyr Cys Met Glu Asn Leu Asp Leu Leu Gly 
    130                 135                 140                 


Pro Thr Asp Val Asp Ala Leu Met Ser Met Leu Arg Ser Leu Ser Arg 
145                 150                 155                 160 


Val Asp Leu Gln Arg Gln Val Gln Thr Leu Met Gly Leu His Leu Ser 
                165                 170                 175     


Gly Pro Ser His Ser Gln His Tyr Arg His Thr Pro 
            180                 185             


<210>  8
<211>  567
<212>  DNA
<213>  Viral sequence

<400>  8
atggccactt acgaggttct ctgtgaggtg gcgcggaaac tgggcacgga tgacagggaa       60

gtggtattgt tcctcctaaa cgtgttcata cctcaaccca cactggccca attaattgga      120

gctcttagag ctttaaagga ggagggcagg ttaacgtttc ccctgttagc ggaatgtctg      180

tttcgtgcag gtcgcagaga cctcttgcgc gacctgcttc acttagaccc gcgtttttta      240

gagcgccacc tagcgggcac aatgagttat ttcagccctt atcagctcac tgttctccac      300

gtagacgggg agctgtgtgc gagggatatt aggtctttga tatttttaag caaggacact      360

atagggtctc gcagcacacc acagacattc ttacactggg tgtactgtat ggaaaactta      420

gacctactgg gtcccactga cgtggatgcc ctaatgtcaa tgcttagatc tttgtcaaga      480

gtagacctac agcgccaagt gcaaacccta atgggccttc acctttccgg cccatcacac      540

tcccaacact atcgccatac accatag                                          567


